CN104069333A - Medicine for treating recurrent oral ulceration and preparation method thereof - Google Patents
Medicine for treating recurrent oral ulceration and preparation method thereof Download PDFInfo
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- CN104069333A CN104069333A CN201410293940.4A CN201410293940A CN104069333A CN 104069333 A CN104069333 A CN 104069333A CN 201410293940 A CN201410293940 A CN 201410293940A CN 104069333 A CN104069333 A CN 104069333A
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Abstract
The invention discloses a medicine for treating recurrent oral ulceration, which comprises bezoar, root of rehmannia, radix scrophulariae, scutellaria baicalensis, jasmine, folium isatidis, borneol, honeysuckle, fructus forsythiae, cortex dictamni, dandelion, giant knot weed, selfheal, raw mulberry bark, hedyotis diffusa, cacumen biotae, salvia miltiorrhiza, fritillaria, coptis chinensis, tendril-leaved fritillary bulb, rheum officinale, root of common peony, liquorice, myrrh, mastic and pearl. The medicine for treating recurrent oral ulceration which is prepared from the bulk drugs has the advantages of remarkable curative effect and small side effects, and the oral ulceration is difficult to relapse.
Description
Technical field
The present invention relates to a kind of medicine of oral ulcer, specifically, relate to a kind of medicine that is used for the treatment of recurrent oral ulceration and preparation method thereof, belong to technical field of Chinese medicines.
Background technology
Recurrent oral ulceration is a kind of very common oral mucosa disease, is commonly called as aphtha.The traditional Chinese medical science thinks, the generation of aphtha is by the heart, spleen, stomach accumulated heat, and intenseness of heat fire-transformation follows through and goes up, and stagnation of QI blood stasis causes meridians to stop up.Diseases caused by exogenous pathogenic factor six climate exopathogens dryness-fire, interior impairment of ZANG FU-organs intenseness of heat, causes aphtha of the mouth and tongue.Often occur together mutually with insomnia, constipation, fatigue, psychentonia, menstrual cycle etc., thereby think a kind of autoimmune disease clinically more.Its basic characteristics of incidence has recurrent exactly, and outbreak is repeatedly difficult to cure.
Treatment recurrent oral ulceration is mainly used following several method at present: use pain relieving antibiotic; Blindly supplement a large amount of vitamin; Arbitrarily use folk prescription etc., above several method is mainly ease the pain or reduce recurrent number, but uncontrollable recurrence, curative effect can not be satisfactory.
Summary of the invention
The problem to be solved in the present invention is the defect existing for prior art, and a kind of medicine that is used for the treatment of recurrent oral ulceration and preparation method thereof is provided, and the medicine of this treatment oral ulcer has evident in efficacy, and the advantage that side effect is little is difficult for recurrence after curing.
For addressing the above problem, the technical solution adopted in the present invention is:
Treat a medicine for recurrent oral ulceration, the efficacy component of described medicine is made by the crude drug of following weight portion:
Gallbladder Calculus Bovis 2-4 part, Radix Rehmanniae 7-9 part, Radix Scrophulariae 6-8 part, Radix Scutellariae 8-10 part, Fructus Gardeniae 7-9 part, Folium Isatidis, Borneolum Syntheticum 1-3 part, Flos Lonicerae 9-11 part, Fructus Forsythiae 8-10 part, Cortex Dictamni 9-11 part, Herba Taraxaci 9-11 part, Rhizoma Polygoni Cuspidati 9-11 part, Spica Prunellae 8-10 part, raw Cortex Mori 6-8 part, Herba Hedyotidis Diffusae 9-11 part, Cacumen Platycladi 9-11 part, Radix Salviae Miltiorrhizae 9-11 part, Bulbus Fritillariae Thunbergii 6-8 part, Rhizoma Coptidis 4-6 part, Bulbus Fritillariae Cirrhosae 9-11 part, Radix Et Rhizoma Rhei 9-11 part, Radix Paeoniae Rubra 7-8 part, Radix Glycyrrhizae 9-11 part, Myrrha 4-6 part, Olibanum 4-6 part and Margarita 9-11 part.
As further improvement:
Treat a medicine for recurrent oral ulceration, the efficacy component of described medicine comprises the crude drug of following weight portion:
10 parts of 3 parts of gallbladder Calculus Boviss, 8 parts, the Radix Rehmanniae, 7 parts of Radix Scrophulariaes, 9 parts of Radix Scutellariaes, 8 parts of Fructus Gardeniaes, 10 parts of Folium Isatidiss, 2 parts of Borneolum Syntheticums, 10 parts of Flos Loniceraes, 9 parts of Fructus Forsythiaes, 10 parts of Cortex Dictamni, 10 parts of Herba Taraxacis, 10 parts of Rhizoma Polygoni Cuspidati, 9 parts of Spica Prunellaes, 7 parts of raw Cortex Mori, 10 parts of Herba Hedyotidis Diffusae, 10 parts of Cacumen Platycladis, 10 parts of Radix Salviae Miltiorrhizaes, 7 parts of Bulbus Fritillariae Thunbergii, 5 parts of Rhizoma Coptidis, 10 parts of Bulbus Fritillariae Cirrhosae, 10 parts of Radix Et Rhizoma Rhei, 9 parts of Radix Paeoniae Rubra, 10 parts, Radix Glycyrrhizae, 5 parts of Myrrhas, 5 parts of Olibanums and Margaritas.
The raw material of Chinese medicine of above-mentioned weight proportion is made to the oral Chinese patent medicine of capsule formulation.
As further improvement:
A preparation method for the treatment of the medicine of recurrent oral ulceration, comprises the following steps:
1), get the crude drug of above-mentioned weight portion standby;
2), add 2 parts of yellow wine to stir Radix Et Rhizoma Rhei, Rhizoma Coptidis, gallbladder Calculus Bovis, seal 48 hours, slow fire fried dry; Be ground into and segmented 120 mesh sieves, obtain medicament A;
3) the water soaking half an hour, by Radix Scutellariae, Cortex Dictamni, Fructus Forsythiae, Herba Taraxaci with 2 times, boil 30-60 minute, after filtrate, medicinal residues add 1.5 times of decoctings 15 minutes, twice filtrate extracting solution are merged and are decocted, reconcentration 2-3 hour; Filtrate is concentrated into relative density 1.05-1.15, and temperature adds ethanol while being 70 ℃ until reach 60% containing amount of alcohol, fully stir, standing 24 hours, leaching supernatant, reclaim ethanol extremely without alcohol taste, while continuing to be concentrated into temperature 70 C, relative density is 1.35-1.40, becomes thick paste final vacuum to dry, pulverize, cross 120 mesh sieves, obtain medicament B;
4), Olibanum, Myrrha are added to 1 part of white vinegar, stir, room temperature keeps 24 hours, and middle fire drying, is ground into fine powder, crosses 120 mesh sieves, obtains medicament C;
5), by the Radix Rehmanniae, Radix Scrophulariae, Fructus Gardeniae, Folium Isatidis, Borneolum Syntheticum, Flos Lonicerae, Rhizoma Polygoni Cuspidati, Spica Prunellae, raw Cortex Mori, Herba Hedyotidis Diffusae, Cacumen Platycladi, Radix Salviae Miltiorrhizae, Bulbus Fritillariae Thunbergii, Bulbus Fritillariae Cirrhosae, Radix Paeoniae Rubra, Radix Glycyrrhizae and Margarita with 2 times of water soaking half an hour, add 10 times of water boils, extract 3 times, each boiling time is 40 minutes, and extracting solution was mixed to 200 mesh sieves, get filtrate, at 60-80 ℃, be evaporated to relative density 1.35-1.40, become thick paste final vacuum to dry, pulverize, cross 120 mesh sieves, obtain medicament D;
6), by step 2), 3), 4), 5) medicament A, B, C, the D mix homogeneously of gained, use Co 60 radiation sterilization, obtain sterile dry, be the medicine for the treatment of recurrent oral ulceration.
7), above-mentioned Chinese medicine is prepared to conventional method by Chinese medicinal capsule in sterilizing room, pack 0.3g capsule into, must treat the capsule of recurrent oral ulceration, this capsule can be preserved 2-3.
This medicine is morning and evening twice one after each meal, each 1-3 grain.
The present invention has drawn Traditional Chinese Medicine expert clinical experience elite, in conjunction with modern Chinese medicine otorhinolaryngology, Chinese medicine and pharmacy, Chinese herbology opinion, with invigorating the spleen and benefiting QI, the kidney invigorating tonifying YIN, blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, detumescence antiinflammatory, granulation promoting pain relieving and compositing formula.Gallbladder Calculus Bovis in side (also claiming Calculus Bovis), Rhizoma Coptidis, Radix Et Rhizoma Rhei, Radix Scutellariae heat-clearing and toxic substances removing; Borneolum Syntheticum, Radix Paeoniae Rubra, Myrrha, Olibanum reducing swelling and alleviating pain; Radix Glycyrrhizae, Bulbus Fritillariae Cirrhosae, raw Cortex Mori invigorating the spleen and replenishing QI; clearing heat and moistening lung; the Radix Rehmanniae, Cacumen Platycladi, Radix Scrophulariae the kidney invigorating tonifying YIN, Rhizoma Polygoni Cuspidati stomach invigorating is eaten clearly, and Spica Prunellae is let out clearly liver-fire; Herba Hedyotidis Diffusae promoting urination to remove dampness, Fructus Forsythiae, Flos Lonicerae, Fructus Gardeniae, Folium Isatidis, Herba Taraxaci, Cortex Dictamni, Bulbus Fritillariae Thunbergii, Margarita are strengthened the power of heat-clearing and toxic substances removing.Take a broad view of full side, coordinate, jointly coordinate, arrange in pairs or groups mutually and be rigorous, drug effect tangent pathogenesis, stable curative effect is reliable.
Through clinical trial, the present invention has good curative effect to treatment recurrent oral ulceration, can effectively treat recurrent oral ulceration, and 3-5 of the present invention days is a course for the treatment of, takes a course for the treatment of and just can fully recover.
Adopt Recurrent Oral Ulcer Treated by Chinese Herb of the present invention, effective percentage reaches more than 90%, and is difficult for recurrence after drug withdrawal, there is no significant side effect.
The specific embodiment
Embodiment 1, and a kind of medicine for the treatment of recurrent oral ulceration is made by following weight portion crude drug:
10 parts of 3 parts of gallbladder Calculus Boviss, 8 parts, the Radix Rehmanniae, 7 parts of Radix Scrophulariaes, 9 parts of Radix Scutellariaes, 8 parts of Fructus Gardeniaes, 10 parts of Folium Isatidiss, 2 parts of Borneolum Syntheticums, 10 parts of Flos Loniceraes, 9 parts of Fructus Forsythiaes, 10 parts of Cortex Dictamni, 10 parts of Herba Taraxacis, 10 parts of Rhizoma Polygoni Cuspidati, 9 parts of Spica Prunellaes, 7 parts of raw Cortex Mori, 10 parts of Herba Hedyotidis Diffusae, 10 parts of Cacumen Platycladis, 10 parts of Radix Salviae Miltiorrhizaes, 7 parts of Bulbus Fritillariae Thunbergii, 5 parts of Rhizoma Coptidis, 10 parts of Bulbus Fritillariae Cirrhosae, 10 parts of Radix Et Rhizoma Rhei, 9 parts of Radix Paeoniae Rubra, 10 parts, Radix Glycyrrhizae, 5 parts of Myrrhas, 5 parts of Olibanums and Margaritas.
Embodiment 2, and a kind of medicine for the treatment of recurrent oral ulceration is made by following crude drug:
9 parts of 2 parts of gallbladder Calculus Boviss, 7 parts, the Radix Rehmanniae, 6 parts of Radix Scrophulariaes, 8 parts of Radix Scutellariaes, 7 parts of Fructus Gardeniaes, 9 parts of Folium Isatidiss, 1 part of Borneolum Syntheticum, 9 parts of Flos Loniceraes, 8 parts of Fructus Forsythiaes, 9 parts of Cortex Dictamni, 9 parts of Herba Taraxacis, 9 parts of Rhizoma Polygoni Cuspidati, withered 8 parts of summer, 6 parts of raw Cortex Mori, 9 parts of Herba Hedyotidis Diffusae, 9 parts, leaf of side uncle, 9 parts of Radix Salviae Miltiorrhizaes, 6 parts of Bulbus Fritillariae Thunbergii, 4 parts of Rhizoma Coptidis, 9 parts of Bulbus Fritillariae Cirrhosae, 9 parts of Radix Et Rhizoma Rhei, 7 parts of Radix Paeoniae Rubra, 9 parts, Radix Glycyrrhizae, 4 parts of Myrrhas, 4 parts of Olibanums and Margaritas.
Embodiment 3, and a kind of medicine for the treatment of recurrent oral ulceration is made by following crude drug:
11 parts of 4 parts of gallbladder Calculus Boviss, 9 parts, the Radix Rehmanniae, 8 parts of Radix Scrophulariaes, 10 parts of Radix Scutellariaes, 9 parts of Fructus Gardeniaes, 11 parts of Folium Isatidiss, 3 parts of Borneolum Syntheticums, 11 parts of Flos Loniceraes, 10 parts of Fructus Forsythiaes, 11 parts of Cortex Dictamni, 11 parts of Herba Taraxacis, 11 parts of Rhizoma Polygoni Cuspidati, withered 10 parts of summer, 8 parts of raw Cortex Mori, 11 parts of Herba Hedyotidis Diffusae, 11 parts, leaf of side uncle, 11 parts of Radix Salviae Miltiorrhizaes, 8 parts of Bulbus Fritillariae Thunbergii, 6 parts of Rhizoma Coptidis, 11 parts of Bulbus Fritillariae Cirrhosae, 11 parts of Radix Et Rhizoma Rhei, 8 parts of Radix Paeoniae Rubra, 11 parts, Radix Glycyrrhizae, 6 parts of Myrrhas, 6 parts of Olibanums and Margaritas.
Embodiment 4, and a kind of medicine for the treatment of recurrent oral ulceration is made by following crude drug:
2.5 parts of gallbladder Calculus Boviss, 7.5 parts, the Radix Rehmanniae, 6.5 parts of Radix Scrophulariaes, 8.5 parts of Radix Scutellariaes, 7.5 parts of Fructus Gardeniaes, 9.5 parts of Folium Isatidiss, 1.5 parts of Borneolum Syntheticums, 9.5 parts of Flos Loniceraes, 8.5 parts of Fructus Forsythiaes, 9.5 parts of Cortex Dictamni, 9.5 parts of Herba Taraxacis, 9.5 parts of Rhizoma Polygoni Cuspidati, withered 8.5 parts of summer, 6.5 parts of raw Cortex Mori, 9.5 parts of Herba Hedyotidis Diffusae, 9.5 parts, side uncle leaf, 9.5 parts of Radix Salviae Miltiorrhizaes, 6.5 parts of Bulbus Fritillariae Thunbergii, 4.5 parts of Rhizoma Coptidis, 9.5 parts of Bulbus Fritillariae Cirrhosae, 9.5 parts of Radix Et Rhizoma Rhei, 7.5 parts of Radix Paeoniae Rubra, 9.5 parts, Radix Glycyrrhizae, 4.5 parts of Myrrhas, 9.5 parts of 4.5 parts of Olibanums and Margaritas.
Embodiment 5, and a kind of medicine for the treatment of recurrent oral ulceration is made by following crude drug:
3.5 parts of gallbladder Calculus Boviss, 8.5 parts, the Radix Rehmanniae, 7.5 parts of Radix Scrophulariaes, 9.5 parts of Radix Scutellariaes, 8.5 parts of Fructus Gardeniaes, 10.5 parts of Folium Isatidiss, 2.5 parts of Borneolum Syntheticums, 10.5 parts of Flos Loniceraes, 9.5 parts of Fructus Forsythiaes, 10.5 parts of Cortex Dictamni, 10.5 parts of Herba Taraxacis, 10.5 parts of Rhizoma Polygoni Cuspidati, withered 9.5 parts of summer, 7.5 parts of raw Cortex Mori, 10.5 parts of Herba Hedyotidis Diffusae, 10.5 parts, side uncle leaf, 10.5 parts of Radix Salviae Miltiorrhizaes, 7.5 parts of Bulbus Fritillariae Thunbergii, 5.5 parts of Rhizoma Coptidis, 10.5 parts of Bulbus Fritillariae Cirrhosae, 10.5 parts of Radix Et Rhizoma Rhei, 9.5 parts of Radix Paeoniae Rubra, 10.5 parts, Radix Glycyrrhizae, 5.5 parts of Myrrhas, 10.5 parts of 5.5 parts of Olibanums and Margaritas.
The preparation method of medicine of the present invention comprises following processing step:
1), get the crude drug of above-mentioned weight portion standby;
2), add 2 parts of yellow wine to stir Radix Et Rhizoma Rhei, Rhizoma Coptidis, gallbladder Calculus Bovis, seal 48 hours, slow fire fried dry; Be ground into fine powder and cross 120 mesh sieves, obtain medicament A;
3) the water soaking half an hour, by Radix Scutellariae, Cortex Dictamni, Fructus Forsythiae, Herba Taraxaci with 2 times, boil 30-60 minute, after filtrate, medicinal residues add 1.5 times of decoctings 15 minutes, twice filtrate extracting solution are merged and are decocted, reconcentration 2-3 hour; Filtrate is concentrated into relative density 1.05-1.15, and temperature adds ethanol while being 70 ℃ until reach 60% containing amount of alcohol, fully stir, standing 24 hours, leaching supernatant, reclaim ethanol extremely without alcohol taste, while continuing to be concentrated into temperature 70 C, relative density is 1.35-1.40, becomes thick paste final vacuum to dry, pulverize, cross 120 mesh sieves, obtain medicament B;
4), Olibanum, Myrrha are added to 1 part of white vinegar, stir, room temperature keeps 24 hours, and middle fire drying, is ground into fine powder, crosses 120 mesh sieves, obtains medicament C;
5), by the Radix Rehmanniae, Radix Scrophulariae, Fructus Gardeniae, Folium Isatidis, Borneolum Syntheticum, Flos Lonicerae, Rhizoma Polygoni Cuspidati, Spica Prunellae, raw Cortex Mori, Herba Hedyotidis Diffusae, Cacumen Platycladi, Radix Salviae Miltiorrhizae, Bulbus Fritillariae Thunbergii, Bulbus Fritillariae Cirrhosae, Radix Paeoniae Rubra, Radix Glycyrrhizae and Margarita with 2 times of water soaking half an hour, add 10 times of water boils, extract 3 times, each boiling time is 40 minutes, and extracting solution was mixed to 200 mesh sieves, get filtrate, at 60-80 ℃, be evaporated to relative density 1.35-1.40, become thick paste final vacuum to dry, pulverize, cross 120 mesh sieves, obtain medicament D;
6), by step 2), 3), 4), 5) medicament A, B, C, the D mix homogeneously of gained, use Co 60 radiation sterilization, obtain sterile dry, be the medicine for the treatment of recurrent oral ulceration.
7), above-mentioned Chinese medicine is prepared to conventional method by Chinese medicinal capsule in sterilizing room, pack 0.3g capsule into, must treat recurrent oral ulceration capsule, this capsule can be preserved 2-3.
The usage of Chinese medicine of the present invention and consumption: this medicine is morning and evening twice one after each meal, and each 1-3 grain, 3-5 days is a course for the treatment of, takes a course for the treatment of and just can fully recover.
Clinical treatment recurrent oral ulceration 554 examples between 3 years, male's 239 examples wherein, women's 325 examples, age reckling 8 years old, the maximum 76 years old, medical history 1 year to 10 years.120 examples are taken the medicine making in the embodiment of the present invention 1, as the 1st group; 53 examples are taken the medicine making in the embodiment of the present invention 2, as the 2nd group; 78 examples are taken the medicine making in the embodiment of the present invention 3, as 3 groups; 100 examples are taken the medicine making in the embodiment of the present invention 4, as the 4th group; 95 examples are taken the medicine making in the embodiment of the present invention 5, as 5 groups; 108 examples are taken XILEI SAN, and as 6 groups of contrast groups, experimental result sees the following form:
Curative effect determinate standard, is as the criterion with ulcer healing degree and the scorching hot degree of pain:
Clinical effective: medication is transference cure after 3 days, sign all disappears substantially, ulcer healing.
Effective: medication is transference cure after 3 days, and sign has clear improvement, ulcer shoals and diminishes.
Invalid: medication after 5 days cardinal symptom sign improve not obviously, ulcer is substantially unchanged.
As seen from the above table, embodiment 1 effective percentage reaches more than 98%, and obvious effective rate reaches more than 90%, and inefficiency is lower than 5%; Embodiment 2,3,4,5 effective percentage all reach more than 90%, and obvious effective rate reaches more than 85%, and inefficiency is optimum embodiment of the present invention lower than 10%, embodiment 1.
The above is giving an example of best mode for carrying out the invention, and the part of wherein not addressing is in detail those of ordinary skills' common practise.Protection scope of the present invention is as the criterion with the content of claim, and any equivalent transformation carrying out based on technology enlightenment of the present invention, also within protection scope of the present invention.
Claims (3)
1. a medicine for the treatment of recurrent oral ulceration, is characterized in that: the efficacy component of described medicine comprises the crude drug of following weight portion:
Gallbladder Calculus Bovis 2-4 part, Radix Rehmanniae 7-9 part, Radix Scrophulariae 6-8 part, Radix Scutellariae 8-10 part, Fructus Gardeniae 7-9 part, Folium Isatidis, Borneolum Syntheticum 1-3 part, Flos Lonicerae 9-11 part, Fructus Forsythiae 8-10 part, Cortex Dictamni 9-11 part, Herba Taraxaci 9-11 part, Rhizoma Polygoni Cuspidati 9-11 part, Spica Prunellae 8-10 part, raw Cortex Mori 6-8 part, Herba Hedyotidis Diffusae 9-11 part, Cacumen Platycladi 9-11 part, Radix Salviae Miltiorrhizae 9-11 part, Bulbus Fritillariae Thunbergii 6-8 part, Rhizoma Coptidis 4-6 part, Bulbus Fritillariae Cirrhosae 9-11 part, Radix Et Rhizoma Rhei 9-11 part, Radix Paeoniae Rubra 7-8 part, Radix Glycyrrhizae 9-11 part, Myrrha 4-6 part, Olibanum 4-6 part and Margarita 9-11 part.
2. a kind of medicine for the treatment of recurrent oral ulceration as claimed in claim 1, is characterized in that: the efficacy component of described medicine comprises the crude drug of following weight portion:
10 parts of 3 parts of gallbladder Calculus Boviss, 8 parts, the Radix Rehmanniae, 7 parts of Radix Scrophulariaes, 9 parts of Radix Scutellariaes, 8 parts of Fructus Gardeniaes, 10 parts of Folium Isatidiss, 2 parts of Borneolum Syntheticums, 10 parts of Flos Loniceraes, 9 parts of Fructus Forsythiaes, 10 parts of Cortex Dictamni, 10 parts of Herba Taraxacis, 10 parts of Rhizoma Polygoni Cuspidati, 9 parts of Spica Prunellaes, 7 parts of raw Cortex Mori, 10 parts of Herba Hedyotidis Diffusae, 10 parts of Cacumen Platycladis, 10 parts of Radix Salviae Miltiorrhizaes, 7 parts of Bulbus Fritillariae Thunbergii, 5 parts of Rhizoma Coptidis, 10 parts of Bulbus Fritillariae Cirrhosae, 10 parts of Radix Et Rhizoma Rhei, 9 parts of Radix Paeoniae Rubra, 10 parts, Radix Glycyrrhizae, 5 parts of Myrrhas, 5 parts of Olibanums and Margaritas.
3. a kind of medicine for the treatment of recurrent oral ulceration as claimed in claim 1 or 2, is characterized in that: described preparation method comprises the following steps:
1), get the crude drug of above-mentioned weight portion standby;
2), add 2 parts of yellow wine to stir Radix Et Rhizoma Rhei, Rhizoma Coptidis, gallbladder Calculus Bovis, seal 48 hours, slow fire fried dry; Be ground into and segmented 120 mesh sieves, obtain medicament A;
3) the water soaking half an hour, by Radix Scutellariae, Cortex Dictamni, Fructus Forsythiae, Herba Taraxaci with 2 times, boil 30-60 minute, after filtrate, medicinal residues add 1.5 times of decoctings 15 minutes, twice filtrate extracting solution are merged and are decocted, reconcentration 2-3 hour; Filtrate is concentrated into relative density 1.05-1.15, and temperature adds ethanol while being 70 ℃ until reach 60% containing amount of alcohol, fully stir, standing 24 hours, leaching supernatant, reclaim ethanol extremely without alcohol taste, while continuing to be concentrated into temperature 70 C, relative density is 1.35-1.40, becomes thick paste final vacuum to dry, pulverize, cross 120 mesh sieves, obtain medicament B;
4), Olibanum, Myrrha are added to 1 part of white vinegar, stir, room temperature keeps 24 hours, and middle fire drying, is ground into fine powder, crosses 120 mesh sieves, obtains medicament C;
5), by the Radix Rehmanniae, Radix Scrophulariae, Fructus Gardeniae, Folium Isatidis, Borneolum Syntheticum, Flos Lonicerae, Rhizoma Polygoni Cuspidati, Spica Prunellae, raw Cortex Mori, Herba Hedyotidis Diffusae, Cacumen Platycladi, Radix Salviae Miltiorrhizae, Bulbus Fritillariae Thunbergii, Bulbus Fritillariae Cirrhosae, Radix Paeoniae Rubra, Radix Glycyrrhizae and Margarita with 2 times of water soaking half an hour, add 10 times of water boils, extract 3 times, each boiling time is 40 minutes, and extracting solution was mixed to 200 mesh sieves, get filtrate, at 60-80 ℃, be evaporated to relative density 1.35-1.40, become thick paste final vacuum to dry, pulverize, cross 120 mesh sieves, obtain medicament D;
6), by step 2), 3), 4), 5) medicament A, B, C, the D mix homogeneously of gained, use Co 60 radiation sterilization, obtain sterile dry, be the medicine for the treatment of recurrent oral ulceration.
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| CN104644866A (en) * | 2015-03-05 | 2015-05-27 | 淄博夸克医药技术有限公司 | Traditional Chinese medicine for treating recurrent oral ulcer |
| CN104800390A (en) * | 2015-05-11 | 2015-07-29 | 王道欣 | External applied pulvis for treating dental ulcer and preparation method |
| CN104887917A (en) * | 2015-07-08 | 2015-09-09 | 潘剑崎 | Traditional Chinese medicine for treating periodontitis |
| CN105288305A (en) * | 2015-11-30 | 2016-02-03 | 延欣虹 | Pharmaceutical composition for curing oral excessive inflammation and gingival pain and swelling and preparation method of pharmaceutical composition |
| CN105343236A (en) * | 2015-10-29 | 2016-02-24 | 陈光辉 | Medicine for treating dental ulcer |
| CN106110036A (en) * | 2016-08-12 | 2016-11-16 | 华梅 | A kind of Chinese medicine composition treating recurrent aphtha and preparation method thereof |
| CN106511161A (en) * | 2016-11-16 | 2017-03-22 | 刘金厚 | Traditional Chinese herbal medicine toothpaste with treatment effect on canker sore |
| CN107661407A (en) * | 2017-10-10 | 2018-02-06 | 季艮 | A kind of Chinese medicine composition for treating canker sore |
| CN116492425A (en) * | 2023-06-08 | 2023-07-28 | 北京蒲禾源生物科技有限公司 | Oral health care medicine and preparation method thereof |
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| CN104644866A (en) * | 2015-03-05 | 2015-05-27 | 淄博夸克医药技术有限公司 | Traditional Chinese medicine for treating recurrent oral ulcer |
| CN104800390A (en) * | 2015-05-11 | 2015-07-29 | 王道欣 | External applied pulvis for treating dental ulcer and preparation method |
| CN104887917A (en) * | 2015-07-08 | 2015-09-09 | 潘剑崎 | Traditional Chinese medicine for treating periodontitis |
| CN105343236A (en) * | 2015-10-29 | 2016-02-24 | 陈光辉 | Medicine for treating dental ulcer |
| CN105288305A (en) * | 2015-11-30 | 2016-02-03 | 延欣虹 | Pharmaceutical composition for curing oral excessive inflammation and gingival pain and swelling and preparation method of pharmaceutical composition |
| CN106110036A (en) * | 2016-08-12 | 2016-11-16 | 华梅 | A kind of Chinese medicine composition treating recurrent aphtha and preparation method thereof |
| CN106511161A (en) * | 2016-11-16 | 2017-03-22 | 刘金厚 | Traditional Chinese herbal medicine toothpaste with treatment effect on canker sore |
| CN107661407A (en) * | 2017-10-10 | 2018-02-06 | 季艮 | A kind of Chinese medicine composition for treating canker sore |
| CN116492425A (en) * | 2023-06-08 | 2023-07-28 | 北京蒲禾源生物科技有限公司 | Oral health care medicine and preparation method thereof |
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Application publication date: 20141001 |