CN116492425A - Oral health care medicine and preparation method thereof - Google Patents

Oral health care medicine and preparation method thereof Download PDF

Info

Publication number
CN116492425A
CN116492425A CN202310673990.4A CN202310673990A CN116492425A CN 116492425 A CN116492425 A CN 116492425A CN 202310673990 A CN202310673990 A CN 202310673990A CN 116492425 A CN116492425 A CN 116492425A
Authority
CN
China
Prior art keywords
parts
health care
oral
oral health
care medicine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202310673990.4A
Other languages
Chinese (zh)
Inventor
黄方柱
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beijing Puheyuan Biotechnology Co ltd
Original Assignee
Beijing Puheyuan Biotechnology Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Puheyuan Biotechnology Co ltd filed Critical Beijing Puheyuan Biotechnology Co ltd
Priority to CN202310673990.4A priority Critical patent/CN116492425A/en
Publication of CN116492425A publication Critical patent/CN116492425A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A61K36/195—Strobilanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315—Isatis, e.g. Dyer's woad
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/744—Gardenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/85—Verbenaceae (Verbena family)
    • A61K36/855—Clerodendrum, e.g. glorybower
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention discloses an oral health care medicine and a preparation method thereof, and relates to the technical field of oral medicines, wherein the oral health care medicine comprises the following raw material components in parts by weight: 6-8 parts of herba melastoma dodecandrum, 6-8 parts of dandelion, 4-6 parts of gardenia, 4-6 parts of fructus forsythiae, 6-8 parts of liquorice, 4-6 parts of poria cocos, 4-6 parts of mulberry leaf, 5-7 parts of dyers woad leaf, 5-7 parts of radix isatidis, 6-8 parts of honeysuckle, 4-6 parts of chrysanthemum, 3-5 parts of lutein, 4-6 parts of astragalus membranaceus, 4-6 parts of bletilla striata, 12-16 parts of purified water, 3-5 parts of chlorhexidine hydrochloride and 0.8-1.2 parts of borneol. The oral health care medicine provided by the invention adopts natural traditional Chinese medicines as raw material components, is green and safe, can play the roles of diminishing inflammation, resisting bacteria and resisting allergy to the oral cavity after being used, can quickly heal ulcer surfaces in the oral cavity, and can relieve body discomfort caused by swelling and pain of gums and swelling and pain of throat.

Description

Oral health care medicine and preparation method thereof
Technical Field
The invention relates to the technical field of oral medicines, in particular to an oral health care medicine and a preparation method thereof.
Background
The oral cavity is the initial part of the digestive tract. The front borrowing crack is communicated with the outside, and the back channel is continuous with the pharynx. The intraoral cavity is composed of two lips, two cheeks, hard palate, soft palate, etc. The oral cavity is provided with teeth, tongue, salivary gland and other organs. In the oral cavity, the oral cavity is divided into an intrinsic oral cavity in the dentition and an oral cavity vestibule around the dentition by taking the dentition as a dividing line.
The oral cavity is the most dominant way for bacteria, viruses, fungi or some other antigens to enter the human body. When some diseases exist in human body, the human body can reflect the smell of the oral cavity. Thus, there is a need to keep the oral cavity healthy.
At present, no oral health care medicine which can effectively diminish inflammation, resist bacteria and has the efficacy of quickly healing ulcer surfaces and resisting allergy exists.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides an oral health care medicine and a preparation method thereof, and the oral health care medicine provided by the invention adopts natural traditional Chinese medicines as raw material components, is green and safe, can play the roles of diminishing inflammation, resisting bacteria and resisting allergy to the oral cavity after being used, can also quickly heal ulcer surfaces in the oral cavity, and relieves the discomfort caused by swelling and pain of gums and swelling and sore throat.
The invention aims at protecting an oral health care medicine, which comprises the following raw material components in parts by weight: 6-8 parts of herba melastoma dodecandrum, 6-8 parts of dandelion, 4-6 parts of gardenia, 4-6 parts of fructus forsythiae, 6-8 parts of liquorice, 4-6 parts of poria cocos, 4-6 parts of mulberry leaf, 5-7 parts of dyers woad leaf, 5-7 parts of radix isatidis, 6-8 parts of honeysuckle, 4-6 parts of chrysanthemum, 3-5 parts of lutein, 4-6 parts of astragalus membranaceus, 4-6 parts of bletilla striata, 12-16 parts of purified water, 3-5 parts of chlorhexidine hydrochloride and 0.8-1.2 parts of borneol.
Preferably, the oral health care medicine comprises the following raw material components in parts by weight: 7 parts of herba melastoma, 7 parts of dandelion, 5 parts of gardenia, 5 parts of fructus forsythiae, 7 parts of liquorice, 5 parts of poria cocos, 5 parts of mulberry leaf, 6 parts of dyers woad leaf, 6 parts of radix isatidis, 7 parts of honeysuckle, 5 parts of chrysanthemum, 4 parts of lutein, 5 parts of astragalus membranaceus, 5 parts of bletilla striata, 14 parts of purified water, 4 parts of chlorhexidine hydrochloride and 1 part of borneol.
Preferably, the oral health care medicine comprises the following raw material components in parts by weight: 6 parts of herba melastoma, 6 parts of dandelion, 4 parts of gardenia, 4 parts of fructus forsythiae, 6 parts of liquorice, 4 parts of poria cocos, 4 parts of mulberry leaf, 5 parts of dyers woad leaf, 5 parts of radix isatidis, 6 parts of honeysuckle, 4 parts of chrysanthemum, 3 parts of lutein, 4 parts of astragalus membranaceus, 4 parts of bletilla striata, 12 parts of purified water, 3 parts of chlorhexidine hydrochloride and 0.8 part of borneol.
Preferably, the oral health care medicine comprises the following raw material components in parts by weight: 8 parts of melastoma dodecandrum, 8 parts of dandelion, 6 parts of gardenia, 6 parts of fructus forsythiae, 8 parts of liquorice, 6 parts of poria cocos, 6 parts of mulberry leaves, 7 parts of dyers woad leaves, 7 parts of radix isatidis, 8 parts of honeysuckle, 6 parts of chrysanthemum, 5 parts of lutein, 6 parts of astragalus membranaceus, 6 parts of bletilla striata, 16 parts of purified water, 5 parts of chlorhexidine hydrochloride and 1.2 parts of borneol.
The invention also aims at protecting the preparation method of the oral health care medicine, which comprises the following steps:
s1, mixing herba melastoma dodecandrum, dandelion, gardenia, fructus forsythiae, liquorice, poria cocos, mulberry leaves, dyers woad leaves, radix isatidis, honeysuckle, chrysanthemum, astragalus and bletilla striata, drying, baking, grinding and sieving to obtain mixed medicinal powder A;
s2, mixing borneol, lutein and chlorhexidine hydrochloride, grinding, and sieving to obtain mixed powder B;
s3, adding an ethanol solution with the concentration of 95% into the mixed medicine powder A, carrying out ultrasonic constant-temperature water bath, soaking, filtering, concentrating the filtrate until no ethanol exists, and filtering again to obtain a mixed medicine extract A;
s4, adding the mixed powder B and purified water into the mixed medicine extract A, and uniformly stirring to obtain the oral health care medicine.
Preferably, in step S1, the drying is performed at 50-60 ℃ for 4-6 hours.
Preferably, in step S1, the baking is performed at 150-210 ℃ for 20-30min.
Preferably, in step S1, the sieving is a 200 mesh sieve.
Preferably, in step S2, the sieving is a 200 mesh sieve.
Preferably, in step S3, the weight part ratio of the mixed powder a to the ethanol solution is 1:6, preparing a base material; the ultrasonic constant temperature water bath is carried out for 60 minutes under the conditions of 60 ℃ and 50 Hz ultrasonic frequency; the soaking is carried out for 20 hours at 25 ℃.
The beneficial effects of the invention are as follows:
(1) The oral health care medicine provided by the invention adopts natural traditional Chinese medicines as raw material components, is green and safe, can play the roles of diminishing inflammation, resisting bacteria and resisting allergy to the oral cavity after being used, can quickly heal ulcer surfaces in the oral cavity, and can relieve body discomfort caused by swelling and pain of gums and swelling and pain of throat.
(2) The preparation method of the oral health care medicine provided by the invention is simple to operate, stable in technology and easy to obtain raw materials, and the prepared product has excellent effect and great popularization value.
Detailed Description
Embodiments of the technical scheme of the present invention will be described in detail below. The following examples are only for more clearly illustrating the technical aspects of the present invention, and thus are merely examples, and are not intended to limit the scope of the present invention.
It is noted that unless otherwise indicated, technical or scientific terms used herein should be given the ordinary meaning as understood by one of ordinary skill in the art to which this invention pertains.
Example 1
The embodiment provides an oral health care medicine, which comprises the following raw material components in parts by weight:
7 parts of herba melastoma, 7 parts of dandelion, 5 parts of gardenia, 5 parts of fructus forsythiae, 7 parts of liquorice, 5 parts of poria cocos, 5 parts of mulberry leaf, 6 parts of dyers woad leaf, 6 parts of radix isatidis, 7 parts of honeysuckle, 5 parts of chrysanthemum, 4 parts of lutein, 5 parts of astragalus membranaceus, 5 parts of bletilla striata, 14 parts of purified water, 4 parts of chlorhexidine hydrochloride and 1 part of borneol.
The embodiment also provides a preparation method of the oral cavity health care medicine, which comprises the following steps:
s1, mixing herba melastoma dodecandrum, dandelion, gardenia, fructus forsythiae, liquorice, poria cocos, mulberry leaves, dyers woad leaves, radix isatidis, honeysuckle, chrysanthemum, astragalus and bletilla striata, drying, baking, grinding and sieving to obtain mixed medicinal powder A;
s2, mixing borneol, lutein and chlorhexidine hydrochloride, grinding, and sieving to obtain mixed powder B;
s3, adding an ethanol solution with the concentration of 95% into the mixed medicine powder A, carrying out ultrasonic constant-temperature water bath, soaking, filtering, concentrating the filtrate until no ethanol exists, and filtering again to obtain a mixed medicine extract A;
s4, adding the mixed powder B and purified water into the mixed medicine extract A, and uniformly stirring to obtain the oral health care medicine.
In step S1, the drying is carried out at 55 ℃ for 5 hours.
In step S1, baking is performed at 180 ℃ for 25min, and the baking is performed until the color is full dark brown.
In step S1, sieving is carried out by a 200-mesh sieve.
In step S2, sieving is carried out by a 200-mesh sieve.
In the step S3, the weight part ratio of the mixed powder A to the ethanol solution is 1:6, preparing a base material; the ultrasonic constant-temperature water bath is carried out for 60 minutes under the conditions of 60 ℃ and 50 Hz ultrasonic frequency; soaking at 25deg.C for 20 hr.
Example 2
The embodiment provides an oral health care medicine, which comprises the following raw material components in parts by weight:
6 parts of herba melastoma, 6 parts of dandelion, 4 parts of gardenia, 4 parts of fructus forsythiae, 6 parts of liquorice, 4 parts of poria cocos, 4 parts of mulberry leaf, 5 parts of dyers woad leaf, 5 parts of radix isatidis, 6 parts of honeysuckle, 4 parts of chrysanthemum, 3 parts of lutein, 4 parts of astragalus membranaceus, 4 parts of bletilla striata, 12 parts of purified water, 3 parts of chlorhexidine hydrochloride and 0.8 part of borneol.
The embodiment also provides a preparation method of the oral cavity health care medicine, which comprises the following steps:
s1, mixing herba melastoma dodecandrum, dandelion, gardenia, fructus forsythiae, liquorice, poria cocos, mulberry leaves, dyers woad leaves, radix isatidis, honeysuckle, chrysanthemum, astragalus and bletilla striata, drying, baking, grinding and sieving to obtain mixed medicinal powder A;
s2, mixing borneol, lutein and chlorhexidine hydrochloride, grinding, and sieving to obtain mixed powder B;
s3, adding an ethanol solution with the concentration of 95% into the mixed medicine powder A, carrying out ultrasonic constant-temperature water bath, soaking, filtering, concentrating the filtrate until no ethanol exists, and filtering again to obtain a mixed medicine extract A;
s4, adding the mixed powder B and purified water into the mixed medicine extract A, and uniformly stirring to obtain the oral health care medicine.
In step S1, the drying is carried out at 55 ℃ for 5 hours.
In step S1, baking is performed at 180 ℃ for 25min, and the baking is performed until the color is full dark brown.
In step S1, sieving is carried out by a 200-mesh sieve.
In step S2, sieving is carried out by a 200-mesh sieve.
In the step S3, the weight part ratio of the mixed powder A to the ethanol solution is 1:6, preparing a base material; the ultrasonic constant-temperature water bath is carried out for 60 minutes under the conditions of 60 ℃ and 50 Hz ultrasonic frequency; soaking at 25deg.C for 20 hr.
Example 3
The embodiment provides an oral health care medicine, which comprises the following raw material components in parts by weight:
8 parts of melastoma dodecandrum, 8 parts of dandelion, 6 parts of gardenia, 6 parts of fructus forsythiae, 8 parts of liquorice, 6 parts of poria cocos, 6 parts of mulberry leaves, 7 parts of dyers woad leaves, 7 parts of radix isatidis, 8 parts of honeysuckle, 6 parts of chrysanthemum, 5 parts of lutein, 6 parts of astragalus membranaceus, 6 parts of bletilla striata, 16 parts of purified water, 5 parts of chlorhexidine hydrochloride and 1.2 parts of borneol.
The embodiment also provides a preparation method of the oral cavity health care medicine, which comprises the following steps:
s1, mixing herba melastoma dodecandrum, dandelion, gardenia, fructus forsythiae, liquorice, poria cocos, mulberry leaves, dyers woad leaves, radix isatidis, honeysuckle, chrysanthemum, astragalus and bletilla striata, drying, baking, grinding and sieving to obtain mixed medicinal powder A;
s2, mixing borneol, lutein and chlorhexidine hydrochloride, grinding, and sieving to obtain mixed powder B;
s3, adding an ethanol solution with the concentration of 95% into the mixed medicine powder A, carrying out ultrasonic constant-temperature water bath, soaking, filtering, concentrating the filtrate until no ethanol exists, and filtering again to obtain a mixed medicine extract A;
s4, adding the mixed powder B and purified water into the mixed medicine extract A, and uniformly stirring to obtain the oral health care medicine.
In step S1, the drying is carried out at 55 ℃ for 5 hours.
In step S1, baking is performed at 180 ℃ for 25min, and the baking is performed until the color is full dark brown.
In step S1, sieving is carried out by a 200-mesh sieve.
In step S2, sieving is carried out by a 200-mesh sieve.
In the step S3, the weight part ratio of the mixed powder A to the ethanol solution is 1:6, preparing a base material; the ultrasonic constant-temperature water bath is carried out for 60 minutes under the conditions of 60 ℃ and 50 Hz ultrasonic frequency; soaking at 25deg.C for 20 hr.
Test examples
The oral cavity health care drugs prepared in examples 1 to 3 were tested for their effects on treating dental ulcers
The test method comprises randomly selecting 150 local patients with oral ulcer, randomly dividing into three groups of 50 patients with age of 20-50 years, respectively using the oral health care drugs prepared in examples 1-3, uniformly spraying on affected parts, and observing the oral ulcer wound condition of each test object every 6 hours.
Test results: see table 1.
TABLE 1
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present invention, and not for limiting the same; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some or all of the technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit of the invention, and are intended to be included within the scope of the appended claims and description.

Claims (10)

1. An oral health care medicine, which is characterized in that: the oral health care medicine comprises the following raw material components in parts by weight: 6-8 parts of herba melastoma dodecandrum, 6-8 parts of dandelion, 4-6 parts of gardenia, 4-6 parts of fructus forsythiae, 6-8 parts of liquorice, 4-6 parts of poria cocos, 4-6 parts of mulberry leaf, 5-7 parts of dyers woad leaf, 5-7 parts of radix isatidis, 6-8 parts of honeysuckle, 4-6 parts of chrysanthemum, 3-5 parts of lutein, 4-6 parts of astragalus membranaceus, 4-6 parts of bletilla striata, 12-16 parts of purified water, 3-5 parts of chlorhexidine hydrochloride and 0.8-1.2 parts of borneol.
2. The oral care agent according to claim 1, wherein: the oral health care medicine comprises the following raw material components in parts by weight: 7 parts of herba melastoma, 7 parts of dandelion, 5 parts of gardenia, 5 parts of fructus forsythiae, 7 parts of liquorice, 5 parts of poria cocos, 5 parts of mulberry leaf, 6 parts of dyers woad leaf, 6 parts of radix isatidis, 7 parts of honeysuckle, 5 parts of chrysanthemum, 4 parts of lutein, 5 parts of astragalus membranaceus, 5 parts of bletilla striata, 14 parts of purified water, 4 parts of chlorhexidine hydrochloride and 1 part of borneol.
3. The oral care agent according to claim 1, wherein: the oral health care medicine comprises the following raw material components in parts by weight: 6 parts of herba melastoma, 6 parts of dandelion, 4 parts of gardenia, 4 parts of fructus forsythiae, 6 parts of liquorice, 4 parts of poria cocos, 4 parts of mulberry leaf, 5 parts of dyers woad leaf, 5 parts of radix isatidis, 6 parts of honeysuckle, 4 parts of chrysanthemum, 3 parts of lutein, 4 parts of astragalus membranaceus, 4 parts of bletilla striata, 12 parts of purified water, 3 parts of chlorhexidine hydrochloride and 0.8 part of borneol.
4. The oral care agent according to claim 1, wherein: the oral health care medicine comprises the following raw material components in parts by weight: 8 parts of melastoma dodecandrum, 8 parts of dandelion, 6 parts of gardenia, 6 parts of fructus forsythiae, 8 parts of liquorice, 6 parts of poria cocos, 6 parts of mulberry leaves, 7 parts of dyers woad leaves, 7 parts of radix isatidis, 8 parts of honeysuckle, 6 parts of chrysanthemum, 5 parts of lutein, 6 parts of astragalus membranaceus, 6 parts of bletilla striata, 16 parts of purified water, 5 parts of chlorhexidine hydrochloride and 1.2 parts of borneol.
5. A method of preparing an oral care agent according to any one of claims 1 to 4, characterized in that: the preparation method of the oral health care medicine comprises the following steps:
s1, mixing herba melastoma dodecandrum, dandelion, gardenia, fructus forsythiae, liquorice, poria cocos, mulberry leaves, dyers woad leaves, radix isatidis, honeysuckle, chrysanthemum, astragalus and bletilla striata, drying, baking, grinding and sieving to obtain mixed medicinal powder A;
s2, mixing borneol, lutein and chlorhexidine hydrochloride, grinding, and sieving to obtain mixed powder B;
s3, adding an ethanol solution with the concentration of 95% into the mixed medicine powder A, carrying out ultrasonic constant-temperature water bath, soaking, filtering, concentrating the filtrate until no ethanol exists, and filtering again to obtain a mixed medicine extract A;
s4, adding the mixed powder B and purified water into the mixed medicine extract A, and uniformly stirring to obtain the oral health care medicine.
6. The method for preparing an oral care agent according to claim 5, wherein: in the step S1, the drying is carried out for 4-6 hours at 50-60 ℃.
7. The method for preparing an oral care agent according to claim 5, wherein: in the step S1, the baking is performed at 150-210 ℃ for 20-30min.
8. The method for preparing an oral care agent according to claim 5, wherein: in step S1, the sieving is that a 200-mesh sieve is adopted.
9. The method for preparing an oral care agent according to claim 5, wherein: in step S2, the sieving is that a 200-mesh sieve is adopted.
10. The method for preparing an oral care agent according to claim 5, wherein: in the step S3, the weight part ratio of the mixed powder A to the ethanol solution is 1:6, preparing a base material; the ultrasonic constant temperature water bath is carried out for 60 minutes under the conditions of 60 ℃ and 50 Hz ultrasonic frequency; the soaking is carried out for 20 hours at 25 ℃.
CN202310673990.4A 2023-06-08 2023-06-08 Oral health care medicine and preparation method thereof Pending CN116492425A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202310673990.4A CN116492425A (en) 2023-06-08 2023-06-08 Oral health care medicine and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202310673990.4A CN116492425A (en) 2023-06-08 2023-06-08 Oral health care medicine and preparation method thereof

Publications (1)

Publication Number Publication Date
CN116492425A true CN116492425A (en) 2023-07-28

Family

ID=87326840

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202310673990.4A Pending CN116492425A (en) 2023-06-08 2023-06-08 Oral health care medicine and preparation method thereof

Country Status (1)

Country Link
CN (1) CN116492425A (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102836290A (en) * 2012-09-15 2012-12-26 广西嘉进药业有限公司 Chinese herbal tea for preventing and treating flu
CN102861219A (en) * 2011-07-04 2013-01-09 天津太平洋制药有限公司 Traditional Chinese medicine composition for treating oral ulcer
CN104069333A (en) * 2014-06-27 2014-10-01 王文英 Medicine for treating recurrent oral ulceration and preparation method thereof
CN107485684A (en) * 2017-09-25 2017-12-19 四川易创生物科技有限公司 A kind of Chinese medicine composition and preparation method that can quickly treat canker sore
CN108420936A (en) * 2017-04-19 2018-08-21 陈甲芳 A kind of traditional Chinese powder medicine for treating canker sore
CN113332244A (en) * 2021-06-01 2021-09-03 江西德上制药股份有限公司 Antiviral oral spray and preparation method thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102861219A (en) * 2011-07-04 2013-01-09 天津太平洋制药有限公司 Traditional Chinese medicine composition for treating oral ulcer
CN102836290A (en) * 2012-09-15 2012-12-26 广西嘉进药业有限公司 Chinese herbal tea for preventing and treating flu
CN104069333A (en) * 2014-06-27 2014-10-01 王文英 Medicine for treating recurrent oral ulceration and preparation method thereof
CN108420936A (en) * 2017-04-19 2018-08-21 陈甲芳 A kind of traditional Chinese powder medicine for treating canker sore
CN107485684A (en) * 2017-09-25 2017-12-19 四川易创生物科技有限公司 A kind of Chinese medicine composition and preparation method that can quickly treat canker sore
CN113332244A (en) * 2021-06-01 2021-09-03 江西德上制药股份有限公司 Antiviral oral spray and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
李国强;等: "清热解毒方治疗儿童口腔溃疡临床研究", 中医学报, vol. 28, no. 02, 1 February 2013 (2013-02-01), pages 269 - 270 *

Similar Documents

Publication Publication Date Title
KR20010068273A (en) Pharmaceutical compositions for preventing and treating allergic diseases and methods for preparation thereof
CN110946804B (en) Mouthwash for preventing dental caries and oral ulcer and preparation method thereof
CN103495099B (en) Chinese medicine preparation for nursing patient with toothache and preparation method thereof
CN116492425A (en) Oral health care medicine and preparation method thereof
CN109528868A (en) A kind of Chinese medicine composition treats aphthae in preparation, the application in the drug of carbuncle swells furunculosis
CN109700930B (en) Compound traditional Chinese medicine for treating gastric ulcer and duodenal ulcer
CN108704077B (en) Traditional Chinese veterinary medicine composition for treating cat stomatitis and preparation method thereof
CN106421392A (en) Traditional Chinese medicinal gel for treating bedsore and preparation method of traditional Chinese medicinal gel
CN1336169A (en) Medicated toothpaste
CN103933274A (en) Traditional Chinese medicine preparation for treating periodontitis
CN1316241A (en) Health-care liquid of oral cavity and its preparing process
CN1164283C (en) Pulmonotis treating Chinese medicine powder
CN109646591B (en) Composition for oral cavity and application thereof
CN110882270B (en) Pharmaceutical composition containing silicon-based regenerative medical material and preparation method thereof
CN1262300C (en) Medicinal liquid for Hong Kong foot
CN1179952A (en) Formula composition of kebixiao pill and kebixiao plaster and its producing method
CN1306928C (en) Chinese traditional medicine for treating laryngopharyngeal paresthesia and its preparation
CN1391950A (en) Acne clearing liquid
CN105663959A (en) Traditional Chinese medicine preparation for nursing patient suffering from toothache and preparation method
CN105687873A (en) Preparation for treating nasal polyp, and preparation method of preparation
CN105311419A (en) Traditional Chinese medicine composition for treating oral inflammations and preparation method thereof
CN112843152A (en) Traditional Chinese medicine formula for treating decayed teeth and preparation method thereof
CN105687906A (en) Traditional Chinese medicine preparation for treating periodontal diseases and preparation method
CN103638410A (en) Internal decoction for treating periodontitis
CN1593588A (en) Prescription for instant treating gingival hemorrhage and its preparation method

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination