CN1593588A - Quick-acting gingival blood capsule formula for treating gingival bleeding and preparation method thereof - Google Patents
Quick-acting gingival blood capsule formula for treating gingival bleeding and preparation method thereof Download PDFInfo
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- CN1593588A CN1593588A CN 200410041133 CN200410041133A CN1593588A CN 1593588 A CN1593588 A CN 1593588A CN 200410041133 CN200410041133 CN 200410041133 CN 200410041133 A CN200410041133 A CN 200410041133A CN 1593588 A CN1593588 A CN 1593588A
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- 206010018276 Gingival bleeding Diseases 0.000 title claims abstract description 23
- 239000008280 blood Substances 0.000 title claims abstract description 22
- 210000004369 blood Anatomy 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims description 8
- 239000007963 capsule composition Substances 0.000 title claims description 6
- 208000032843 Hemorrhage Diseases 0.000 claims abstract description 17
- 229950006796 spiramycin ii Drugs 0.000 claims abstract description 15
- 241000219784 Sophora Species 0.000 claims abstract description 10
- 241001446509 Psoralea Species 0.000 claims abstract description 6
- 241000270708 Testudinidae Species 0.000 claims abstract description 6
- 241000241550 Cyathula Species 0.000 claims abstract description 5
- 241000628997 Flos Species 0.000 claims description 32
- 239000003814 drug Substances 0.000 claims description 21
- 210000004195 gingiva Anatomy 0.000 claims description 18
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 16
- 239000009636 Huang Qi Substances 0.000 claims description 11
- 239000003292 glue Substances 0.000 claims description 11
- 241000245240 Lonicera Species 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 7
- 238000009835 boiling Methods 0.000 claims description 5
- 238000009837 dry grinding Methods 0.000 claims description 5
- 238000007654 immersion Methods 0.000 claims description 5
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 5
- ACTOXUHEUCPTEW-CEUOBAOPSA-N 2-[(4r,5s,6s,7r,9r,10r,11e,13e,16r)-6-[(2s,3r,4r,5s,6r)-5-[(2s,4r,5s,6s)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-10-[(2r,5s,6r)-5-(dimethylamino)-6-methyloxan-2-yl]oxy-4-hydroxy-5-methoxy-9,16-dimethyl-2-o Chemical compound O([C@H]1/C=C/C=C/C[C@@H](C)OC(=O)C[C@@H](O)[C@@H]([C@H]([C@@H](CC=O)C[C@H]1C)O[C@H]1[C@@H]([C@H]([C@H](O[C@@H]2O[C@@H](C)[C@H](O)[C@](C)(O)C2)[C@@H](C)O1)N(C)C)O)OC)[C@H]1CC[C@H](N(C)C)[C@@H](C)O1 ACTOXUHEUCPTEW-CEUOBAOPSA-N 0.000 claims 2
- 239000004187 Spiramycin Substances 0.000 claims 2
- -1 acyl spiramycins Chemical class 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229930191512 spiramycin Natural products 0.000 claims 2
- 235000019372 spiramycin Nutrition 0.000 claims 2
- ZPCCSZFPOXBNDL-RSMXASMKSA-N spiramycin II Chemical compound O([C@H]1/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]([C@@H]([C@H]([C@@H](CC=O)C[C@H]1C)O[C@H]1[C@@H]([C@H]([C@H](O[C@@H]2O[C@@H](C)[C@H](O)[C@](C)(O)C2)[C@@H](C)O1)N(C)C)O)OC)OC(C)=O)[C@H]1CC[C@H](N(C)C)[C@H](C)O1 ZPCCSZFPOXBNDL-RSMXASMKSA-N 0.000 abstract description 13
- 239000002775 capsule Substances 0.000 abstract description 11
- 210000003734 kidney Anatomy 0.000 abstract description 8
- 210000002784 stomach Anatomy 0.000 abstract description 7
- 210000001519 tissue Anatomy 0.000 abstract description 5
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- 230000008439 repair process Effects 0.000 abstract description 3
- 244000052616 bacterial pathogen Species 0.000 abstract description 2
- 230000000740 bleeding effect Effects 0.000 abstract description 2
- 241000427159 Achyranthes Species 0.000 abstract 1
- 241000205585 Aquilegia canadensis Species 0.000 abstract 1
- 235000008499 Canella winterana Nutrition 0.000 abstract 1
- 244000080208 Canella winterana Species 0.000 abstract 1
- 241000132536 Cirsium Species 0.000 abstract 1
- 244000170916 Paeonia officinalis Species 0.000 abstract 1
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract 1
- 241000405414 Rehmannia Species 0.000 abstract 1
- 235000014220 Rhus chinensis Nutrition 0.000 abstract 1
- 240000003152 Rhus chinensis Species 0.000 abstract 1
- 240000004274 Sarcandra glabra Species 0.000 abstract 1
- 235000010842 Sarcandra glabra Nutrition 0.000 abstract 1
- 229940107666 astragalus root Drugs 0.000 abstract 1
- 229940017545 cinnamon bark Drugs 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 229910052602 gypsum Inorganic materials 0.000 abstract 1
- 239000010440 gypsum Substances 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
- 229940079593 drug Drugs 0.000 description 8
- 208000024283 Gingival haemorrhages Diseases 0.000 description 6
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- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
A quick-acting gingival blood capsule for treating gingival bleeding is prepared from astragalus root, rehmannia root, red peony root, sophora flower, gypsum, psoralea fruit, achyranthes and cyathula root, honeysuckle flower, thistle, Chinese gall, sarcandra glabra, cinnamon bark, tortoise plastron and acetylspiramycin through selecting, washing, breaking, decocting, concentrating, baking and capsulizing. The invention has the functions of clearing stomach fire, nourishing kidney yin, cooling blood and stopping bleeding, and hardening teeth and fixing gum. Inhibit or kill harmful pathogenic bacteria in oral cavity, recover normal flora in oral cavity, promote the repair and growth of gingival tissue, and rapidly stop gingival bleeding.
Description
Technical field
The present invention relates to a kind of is the oral capsule preparation that raw material is made with the Chinese and western drugs, specifically a kind of compound recipe Chinese-western medicine preparation for the treatment of gingiva bleeding gingival hemorrhage---quick-acting gum blood glue capsules.
Background technology
Gingiva bleeding gingival hemorrhage is meant gums not because of the hemorrhage a kind of internal medicine of wound and the common disease of the department of stomatology, and the traditional Chinese medical science claims " tooth blood ", is commonly called as gingival hemorrhage.Its cause of disease has systemic factor and local factor to cause.General gingiva bleeding gingival hemorrhage is that ordinary person is recurrent, through clinical statistics, there is 46% crowd that in various degree gingiva bleeding gingival hemorrhage is all arranged, its sickness rate is higher, especially in vast rural area and outlying district, influence growth of children, influence people's live and work, still do not have the specific medicament that is specifically designed to the treatment gingiva bleeding gingival hemorrhage in the market.
The inventor finds numerous gingiva bleeding gingival hemorrhage patients at one, two, three hospital clinical, then seek old maxim, widely collect crowd side, absorb the elite of Chinese medicine gum blood, and in conjunction with modern medicine, reach the new road of seeking a treatment gingiva bleeding gingival hemorrhage clinically from Chinese and western medicine theory, make the teeth consolidating antiinflammatory, give birth to the therapeutic scheme of gingival hemorrhage, clinical summary, constantly adjust, develop preparation of the present invention.
Summary of the invention
The present invention's purpose is to provide a kind of equilibrium between yin and yang in the control agent that has, sthenia syndrome requiring purgation, deficiency syndrome should be treated by tonifying method, let out stomach-fire clearly, YIN nourishing removing heat from blood, anti-inflammation hemostasia, teeth consolidating is given birth to gum, can reach rapid hemostasis, and can make self repairing of gingiva tissue, improve the quick-acting gum blood glue capsule preparation prescriptions of poison resistance and defence exopathogen ability.
Main material of the present invention is: Radix Astragali, the Radix Rehmanniae, Radix Paeoniae Rubra, Flos Sophorae, Gypsum Fibrosum, Fructus Psoraleae, Radix Cyathulae, Flos Lonicerae, Radix Cirsii Japonici, Galla Chinensis, Herba Pileae Scriptae, Cortex Cinnamomi, Carapax et Plastrum Testudinis, acetylspiramycin.
The weight proportion of above-mentioned each main material is:
Radix Astragali 5～20 Radix Rehmanniae 5～20 Radix Paeoniae Rubra 5～20 Flos Sophoraes 10～40 Gypsum Fibrosum 25～100
Fructus Psoraleae 10～40 Radix Cyathulaes 5～20 Flos Loniceraes 5～20 Radix Cirsii Japonicis 5～20 Galla Chinensiss 5～20
Herba Pileae Scriptae 10～40 Cortex Cinnamomis 5～20 Carapax et Plastrum Testudiniss 10～40 acetylspiramycins 3.5～14.
The preferred weight proportioning raw materials of above-mentioned main material is:
Radix Astragali 10～20 Radix Rehmanniae 10～20 Radix Paeoniae Rubra 10～20 Flos Sophoraes 20～40 Gypsum Fibrosum 50～100
Fructus Psoraleae 20～40 Radix Cyathulaes 10～20 Flos Loniceraes 10～20 Radix Cirsii Japonicis 10～20 Galla Chinensiss 10～20
Herba Pileae Scriptae 20～40 Cortex Cinnamomis 10～20 Carapax et Plastrum Testudiniss 200～40 acetylspiramycins 7～14.
Optimum weight proportioning raw materials of the present invention is:
Radix Astragali 10 Radix Rehmanniae 10 Radix Paeoniae Rubra 10 Flos Sophoraes 20 Gypsum Fibrosum 50 Fructus Psoraleaes 20
Radix Cyathulae 10 Flos Loniceraes 10 Radix Cirsii Japonicis 10 Galla Chinensiss 10 Herba Pileae Scriptaes 20 Cortex Cinnamomis 10
Carapax et Plastrum Testudinis 20 acetylspiramycins 7.
Another object of the present invention provides the capsular preparation method of these quick-acting gum blood:
(1) CARAPAX ET PIASTRUM TESTUDINIS PREPARATA is cleaned the after bake dry grinding;
(2) Radix Rehmanniae, Radix Paeoniae Rubra, Flos Sophorae, Fructus Psoraleae, river ZHUXI, Flos Lonicerae, Radix Cirsii Japonici, Galla Chinensis, Herba Pileae Scriptae, Cortex Cinnamomi are cleaned the back and be mixed together immersion after 4 hours with Gypsum Fibrosum and Tortoise Shell, decoct 2 times, each boiling time that decocts is 30 minutes;
(3) above-mentioned decoction liquor is concentrated and oven dry, add an amount of excipient and acetylspiramycin, incapsulate.
The present invention takes as the leading factor with theory of Chinese medical science, in conjunction with modern medicine, excavates folk remedy, by secular clinical observation gained.The traditional Chinese medical science is thought, the ability to speak words, by the knot network communication, link, follow row, with vital organs of the human body close ties, comparatively close with spleen, stomach, kidney, the heart, liver relation especially, after tooth is kidney, the physiological function of gums and pathological change, relevant with the kidney stomach, gums is under the stomach system, get in touch by meridians, the large intesting channel of Hand-Yangming, the stomach channel of foot-Yang-ming, spleen meridian, kidney meridian, liver channel of foot-Jueyin, the arteries and veins of superintending and directing, appoint, swell all have close ties with ability to speak.Gingiva bleeding gingival hemorrhage is by rising up of stomach-fire, and blood is moving with fire, or hepatic and renal YIN deficiency, and due to the hyperactivity of deficient fire, the present invention transfers internal organs, the meridian dredging, and the clearing stomach nourishing kidney, the removing heat from blood YIN nourishing, teeth consolidating is given birth to gum, makes the strong and gums heavily fortified point of internal organs.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, the present invention selects animals and plants Chinese crude drug and Western medicine acetylspiramycin for use, each component meets tcm theory and modern medical theory, meets the regulation of pharmacopeia and traditional Chinese medical science management condition, drug safety, surplus clinical ten, extensively use in year, do not have obvious anaphylaxis and toxic and side effects.
2, prescription comprehensively, clinical practice is set about from clear excess-fire and asthenic fire two aspects, the clearing stomach fire and the nourishing kidney-yin two big rule of treatment make the rapid removing of fire of the absurd row of forcing blood, let out clearly and just do not hinder, YIN nourishing and do not love heresy.
3, eliminate the gingiva inflammation, the oral cavity is the place of a large amount of bacteria breeds, suppress noxious bacteria breeding growth by acetylspiramycin, two-ways regulation by Chinese medicine again, harmful pathogenic bacterium had both been killed and had removed, the normal flora in oral cavity can be recovered rapidly, reach strengthening the body resistance, the purpose of eliminating evil hemostasis.
4, can firm tooth, repair gingiva tissue, solving single utilization Western medicine can only antiphlogistic defective, and after tooth was kidney, kidney tonifying can teeth consolidating, can repair gingiva tissue fast again, makes its normal growth, has safeguarded the normal function of gingiva tissue.
5, remedy and treat gingival hemorrhage at present clinically and will use multiple medications, side effect and toxicity are bigger, the unfavorable defective of curative effect.Single taking medicine, special effect, economy, convenient.
The present invention is through clinical extensive application, and cure rate is more than 90%, and effective percentage reaches more than 98%.
Medicine specification of the present invention: every capsules contains Chinese medicine 3g, acetylspiramycin 0.1g.
The medicinal method consumption of the present invention: be grown up each 2, every day 3 times, the child is cut down according to the circumstance or is followed the doctor's advice
Points for attention of the present invention: the careful usefulness of anemia of pregnant woman, acetylspiramycin allergy sufferers forbidding.
Model case:
One woman, 14 years old, frequent gingival hemorrhage, amount of bleeding is more sometimes, and anemia is become thin, and growth retardation gives oral 2 of gum blood glue capsule, and obey gingival hemorrhage on the 2nd and promptly end every day 3 times, after treatment 7 days, year surplus examining 10, the gingival hemorrhage recovery from illness, health is good.
The specific embodiment
Example 1 takes by weighing raw material (unit: kilogram) by following proportioning:
Radix Astragali 5 Radix Rehmanniae 5 Radix Paeoniae Rubra 5 Flos Sophoraes 10 Gypsum Fibrosum 25 Fructus Psoraleaes 10
Radix Cyathulae 5 Flos Loniceraes 5 Radix Cirsii Japonicis 5 Galla Chinensiss 5 Herba Pileae Scriptaes 10 Cortex Cinnamomis 5
Carapax et Plastrum Testudinis 10 acetylspiramycins 3.5
CARAPAX ET PIASTRUM TESTUDINIS PREPARATA is cleaned the after bake dry grinding; The Radix Rehmanniae, Radix Paeoniae Rubra, Flos Sophorae, Fructus Psoraleae, river ZHUXI, Flos Lonicerae, Radix Cirsii Japonici, Galla Chinensis, Herba Pileae Scriptae, Cortex Cinnamomi are cleaned the back be mixed together immersion after 4 hours with Gypsum Fibrosum and Tortoise Shell, decoct 2 times, each decocting time is 30 minutes (boiling time); Above-mentioned decoction liquor is concentrated and oven dry, add an amount of excipient and acetylspiramycin, No. 2 capsules (calculate every capsules and contain crude drug 3g, acetylspiramycin 0.1g) of packing into are promptly made quick-acting gum blood glue wafers.
Example 2, press following proportioning weighting raw materials thing (kilogram):
Radix Astragali 20 Radix Rehmanniae 20 Radix Paeoniae Rubra 20 Flos Sophoraes 40 Gypsum Fibrosum 100 Fructus Psoraleaes 40
Radix Cyathulae 20 Flos Loniceraes 20 Radix Cirsii Japonicis 20 Galla Chinensiss 20 Herba Pileae Scriptaes 40 Cortex Cinnamomis 20
Carapax et Plastrum Testudinis 40 acetylspiramycins 14
CARAPAX ET PIASTRUM TESTUDINIS PREPARATA is cleaned the after bake dry grinding; The Radix Rehmanniae, Radix Paeoniae Rubra, Flos Sophorae, Fructus Psoraleae, river ZHUXI, Flos Lonicerae, Radix Cirsii Japonici, Galla Chinensis, Herba Pileae Scriptae, Cortex Cinnamomi are cleaned the back be mixed together immersion after 4 hours with Gypsum Fibrosum and Tortoise Shell, decoct 2 times, each decocting time is 30 minutes (boiling time); Above-mentioned decoction liquor is concentrated and oven dry, add an amount of excipient and acetylspiramycin, No. 2 capsules (calculate every capsules and contain crude drug 3g, acetylspiramycin 0.1g) of packing into are promptly made quick-acting gum blood glue wafers.
Example 3, press following proportioning weighting raw materials thing (kilogram):
Radix Astragali 10 Radix Rehmanniae 10 Radix Paeoniae Rubra 10 Flos Sophoraes 20 Gypsum Fibrosum 50 Fructus Psoraleaes 20
Radix Cyathulae 10 Flos Loniceraes 10 Radix Cirsii Japonicis 10 Galla Chinensiss 10 Herba Pileae Scriptaes 20 Cortex Cinnamomis 10
Carapax et Plastrum Testudinis 20 acetylspiramycins 7
CARAPAX ET PIASTRUM TESTUDINIS PREPARATA is cleaned the after bake dry grinding; The Radix Rehmanniae, Radix Paeoniae Rubra, Flos Sophorae, Fructus Psoraleae, river ZHUXI, Flos Lonicerae, Radix Cirsii Japonici, Galla Chinensis, Herba Pileae Scriptae, Cortex Cinnamomi are cleaned the back be mixed together immersion after 4 hours with Gypsum Fibrosum and Tortoise Shell, decoct 2 times, each decocting time is 30 minutes (boiling time); Above-mentioned decoction liquor is concentrated and oven dry, add an amount of excipient and acetylspiramycin, No. 2 capsules (calculate every capsules and contain crude drug 3g, acetylspiramycin 0.1g) of packing into are promptly made quick-acting gum blood glue wafers.
Claims (5)
1, a kind of quick-acting gum blood glue capsule formulas for the treatment of gingiva bleeding gingival hemorrhage is characterized in that its main material is: Radix Astragali, the Radix Rehmanniae, Radix Paeoniae Rubra, Flos Sophorae, Gypsum Fibrosum, Fructus Psoraleae, Radix Cyathulae, Flos Lonicerae, Radix Cirsii Japonici, Galla Chinensis, Herba Pileae Scriptae, Cortex Cinnamomi, Carapax et Plastrum Testudinis, acetylspiramycin.
2, according to the quick-acting gum blood glue capsule formulas of the described treatment gingiva bleeding gingival hemorrhage of claim 1, it is characterized in that the composition by weight of each main material is:
Radix Astragali 5～20 Radix Rehmanniae 5～20 Radix Paeoniae Rubra 5～20 Flos Sophoraes 10～40 Gypsum Fibrosum 25～100
Fructus Psoraleae 10～40 Radix Cyathulaes 5～20 Flos Loniceraes 5～20 Radix Cirsii Japonicis 5～20 gall nuts 5～20
Herba Pileae Scriptae 10～40 Cortex Cinnamomis 5～20 Carapax et Plastrum Testudiniss 10～40 acyl spiramycins 3.5～14.
3, according to the quick-acting gum blood glue capsule formulas of the described treatment gingiva bleeding gingival hemorrhage of claim 2, it is characterized in that the composition by weight of its main material is:
Radix Astragali 10～20 Radix Rehmanniae 10～20 Radix Paeoniae Rubra 10～20 Flos Sophoraes 20～40 Gypsum Fibrosum 50～100
Fructus Psoraleae 20～40 Radix Cyathulaes 10～20 Flos Loniceraes 10～20 Radix Cirsii Japonicis 10～20 Galla Chinensiss 10～20
Herba Pileae Scriptae 20～40 Cortex Cinnamomis 10～20 Carapax et Plastrum Testudiniss 200～40 acetylspiramycins 7～14.
4, according to the quick-acting gum blood glue capsule formulas of the described treatment gingiva bleeding gingival hemorrhage of claim 3, it is characterized in that the proportioning of its main material medicine is:
Radix Astragali 10 Radix Rehmanniae 10 Radix Paeoniae Rubra 10 Flos Sophoraes 20 Gypsum Fibrosum 50 Fructus Psoraleaes 20
Radix Cyathulae 10 Flos Loniceraes 10 Radix Cirsii Japonicis 10 Galla Chinensiss 10 Herba Pileae Scriptaes 20 Cortex Cinnamomis 10
Carapax et Plastrum Testudinis 20 acyl spiramycins 7.
5, a kind of capsular preparation method of quick-acting gum blood for the treatment of gingiva bleeding gingival hemorrhage is:
(1) CARAPAX ET PIASTRUM TESTUDINIS PREPARATA is cleaned the after bake dry grinding;
(2) Radix Rehmanniae, Radix Paeoniae Rubra, Flos Sophorae, Fructus Psoraleae, river ZHUXI, Flos Lonicerae, Radix Cirsii Japonici, Galla Chinensis, Herba Pileae Scriptae, Cortex Cinnamomi are cleaned the back and be mixed together immersion after 4 hours with Gypsum Fibrosum and Tortoise Shell, decoct 2 times, each boiling time that decocts is 30 minutes;
(3) above-mentioned decoction liquor is concentrated and oven dry, add an amount of excipient and acetylspiramycin, incapsulate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410041133 CN1593588A (en) | 2004-06-28 | 2004-06-28 | Quick-acting gingival blood capsule formula for treating gingival bleeding and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410041133 CN1593588A (en) | 2004-06-28 | 2004-06-28 | Quick-acting gingival blood capsule formula for treating gingival bleeding and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN1593588A true CN1593588A (en) | 2005-03-16 |
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| CN 200410041133 Pending CN1593588A (en) | 2004-06-28 | 2004-06-28 | Quick-acting gingival blood capsule formula for treating gingival bleeding and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103585460A (en) * | 2013-11-06 | 2014-02-19 | 周慧 | Packing agent for gingival hemostasis |
| CN106955320A (en) * | 2017-05-24 | 2017-07-18 | 山西药科职业学院 | A kind of preparation method for being used to treat the Chinese medicine preparation of bleeding gums |
-
2004
- 2004-06-28 CN CN 200410041133 patent/CN1593588A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103585460A (en) * | 2013-11-06 | 2014-02-19 | 周慧 | Packing agent for gingival hemostasis |
| CN106955320A (en) * | 2017-05-24 | 2017-07-18 | 山西药科职业学院 | A kind of preparation method for being used to treat the Chinese medicine preparation of bleeding gums |
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