CN1091609C - Tincture for treating rheumatoid arthritis and its preparing process - Google Patents

Abstract

The present invention discloses a tincture for curing rheumatoid arthritis and a preparation method thereof. The tincture is prepared from 30 to 60g of dendrobium, 20 to 30g of prepared rhizome of rehmannia, 6 to 12g of prepared common monkshood daughter root, 10 to 15g of radix dipsaci from Sichuan of China, 10 to 20g of psoralea fruit, 10 to 45g of common threewingnut root, 30 to 60g of ovientvine, 9 to 15g of cassia twig, 10 to 15g of incised notoptetygium rhizome or root, 10 to 15g of doubleteeth pubesscent angelica root, 10 to 15g of white peony alba, 10 to 15g of Chinese clematis, 20 to 30g of common clubmoss herb, 30 to 60g of milkvetch root, 10g of fourstamen stephania root, 10g of ledebouriella root, 10g of atractylodes rhizome, 10g of largehead atractylodes rhizome, 10 to 30g of manchurian wildginger, 15g of earth worm, 30g of suberect spatholobus, 10 to 15g of red peony root, 10g of common anemarrhena rhizome, 6 to 10g of ground beetle, 10g of combined spicebush root, 10g of licorice root, 10 to 15g of twotoothed achyranthes root, etc. The tincture can take effect quickly and has the strong function of improving symptoms and physical symptoms.

Description

Tincture of treatment rheumatoid arthritis and preparation method thereof

The present invention relates to a kind of Chinese medicine preparation, relate in particular to a kind of tincture of being processed as the treatment rheumatoid arthritis by several kinds of Chinese medicinal materials.

Rheumatoid arthritis (RA) is a kind of systemic disease of invading connective tissue.This interior syndrome doctor scope belongs to arthromyodynia, and the endogenous cause of ill of its cause of disease is that QI and blood battalion defends interior-deficiency, factors such as the outer because damp and hot heresy of wind and cold, inducement then be climate change, living environment, overwork, body void.This disease is in early days based on the domination of pathogen, and late period is vital QI being weakened and pathogen being violent and seeing then, does not heal year in year out, can injure internal organs, amyotrophy takes place, osteoporosis, joint heavy damage, form symptoms such as tetanic or dislocation, bring great misery to the patient, even the forfeiture work and the ability of taking care of oneself.

At present,, implement comprehensive treatments such as the combination of Chinese and Western medicine usually, still lack single effective Therapeutic Method clinically patient with rheumatoid arthritis.

The present invention is intended to use the traditional Chinese medical science to emphasize the equilibrated immune thought of the whole negative and positive perpetual motion of human body self, makes it to combine with modern theory of immunity, inquires into the novel composing prescription tincture of treatment rheumatoid arthritis.

The objective of the invention is to use the base therapy rule of traditional Chinese medical science strengthening vital QI to eliminate pathogenic factors, a kind of tincture for the treatment of rheumatoid arthritis is provided.

Another object of the present invention is to provide a kind of method for preparing described tincture.

The technical scheme that is used to reach the object of the invention is as follows:

The present invention treats the tincture of rheumatoid arthritis, wherein contains:

The windproof 10 gram rhizoma atractylodis of the celestial 10-15 gram of the stem of noble dendrobium 30-60 gram cultivated land 20-30 gram monkshood 6-12 gram river disconnected 10-15 gram Psoralea corylifolia 10-20 gram thunder godvine 10-45 gram caulis sinomenii 30-60 gram cassia twig 9-15 gram notopterygium root 10-15 gram levisticum 10-15 gram root of herbaceous peony 10-15 kairine lycopodium calvatum 20-30 gram Radix Astragali 30-60 gram root of fangji 10 grams 10 gram bighead atractylodes rhizomes 10 gram root of Chinese wild ginger 10-30 gram earthworms 15 gram reticulate millettias 30 gram radix paeoniae rubrathe 10-15 gram wind-weeds 10 gram ground beetle 6-10 gram roots of three-nerved spicebush 10 grams Radix Glycyrrhizae 10 gram root of bidentate achyranthes 10-15 gram is take 500 gram doses as unit; Wherein moisture 500 milliliters, 2500 milliliters of, 50 degree high-quality grain wine.

Treat among the embodiment of tincture of rheumatoid arthritis in the present invention, contain:

The celestial 10 gram Herba Lycopodiis of the Herba Dendrobii 50 gram Radix Rehmanniaes Preparata 25 gram Radix Aconiti Lateralis Preparatas 10 gram Radix Dipsaci 15 gram Fructus Psoraleaes 15 Cray Tripterygium wilfordii 15 gram Caulis Sinomeniis 45 gram Ramulus Cinnamomi 12 gram Rhizoma Et Radix Notopterygiis 15 gram Radix Angelicae Pubescentiss 15 gram Radix Paeoniae Albas 15 kairines 30 gram Radixs Astragali 60 gram Radixs Stephaniae Tetrandrae 10 gram Radix Saposhnikoviaes 10 gram Rhizoma Atractylodis 10 gram Rhizoma Atractylodis Macrocephalaes 10 gram Herba Asaris 20 gram Pheretimas 15 gram Caulis Spatholobis 30 gram Radix Paeoniae Rubra 15 gram Rhizoma Anemarrhenaes 10 gram Eupolyphaga Seu Steleophagas 10 gram Radixs Linderae 10 gram Radix Glycyrrhizaes 10 gram Radix Achyranthis Bidentataes 15 grams is a unit with 500 gram doses, wherein moisture 500 milliliters, 2500 milliliters of 50 degree high-quality grain wine.

In treating another embodiment of tincture of rheumatoid arthritis, the present invention contains:

The windproof 10 gram rhizoma atractylodis of the celestial 10 gram lycopodium calvatums of the stem of noble dendrobium 50 gram cultivated lands 25 gram monkshoods 10 gram rivers disconnected 15 gram Psoralea corylifolias 15 gram thunder godvines 15 gram caulis sinomeniis, 45 gram cassia twig, 12 gram notopterygium roots, 15 gram levisticums, the 15 gram root of herbaceous peonys, the 15 kairines 30 gram Radixs Astragali 60 gram roots of fangji 10 grams 10 gram bighead atractylodes rhizomes 10 gram roots of Chinese wild ginger 20 gram earthworms 15 gram reticulate millettias 30 gram radix paeoniae rubrathe 15 gram wind-weeds 10 gram ground beetles 10 gram roots of three-nerved spicebush 10 grams Radix Glycyrrhizae 10 gram root of bidentate achyranthes 15 gram Radix Angelicae Sinensis 25 gram red sage root 25 gram HERBA EPIMEDII 30 gram honeycomb 15 gram is take 500 gram doses as unit; Wherein moisture 500 milliliters, 2500 milliliters of, 50 degree high-quality grain wine.

Preparation the present invention treats the method for the tincture of rheumatoid arthritis, the steps include:

1. each medicine in the described tincture is broken into 80 purpose coarse powder, and mixes by described proportioning;

2. be that unit is distributed into bag with husky cloth with said mixture with 500 grams;

3. every bag of mixture after 1 hour, is decocted the 300ml that takes concoction with the cold water soak of 1500ml, and then add 1000ml cold water and carry out second time and decoct, 200ml takes concoction;

4. the medicine after will decocting the 500ml medicine juice that takes out after two times and decocting extracting juice is together put into glass container, pours 50 degree high-quality grain wine 2500ml soak medicines into, sealed glass container;

5. soak the supernatant that takes out after 10 days in the glass container and divide the bottle encapsulation, every bottle is 250ml.

The advantage that the present invention treats the tincture of rheumatoid arthritis is: to active stage rheumatoid arthritis the therapeutical effect of highly significant is arranged, its obvious effective rate and total effective rate are all high, are in particular in: 1. begin onset time fast (P＜0.05); 2. improve symptom, the Signs effect is strong, obviously pain relieving, detumescence, reduction erythrocyte sedimentation rate and the significantly RA effect of turning out cloudy, and can obviously reduce IgG, IgA, IgM.

Tincture of the present invention, wherein with Radix Rehmanniae Preparata the kidney invigorating essence, nourishing kidney-yin, smart and the puckery vigour of Herba Dendrobii the kidney invigorating, strong waist knee joint, hard muscles and bones, with Radix Dipsaci, Fructus Psoraleae kidney-replenishing, Radix Aconiti Lateralis Preparata invigorating kidney-YANG cold relieving heresy, the Radix Linderae and Herba Dendrobii, Radix Rehmanniae Preparata and the negative and positive of transferring kidney, the benefit QI of the spleen and stomach, and then adjust human body from whole negative and positive perpetual motion balance.It is main that Radix Tripterygii Wilfordii goes into Liver Channel, doublely goes into the spleen kidney, and heat-clearing and toxic substances removing is arranged, expelling wind and removing dampness, and effects such as relaxing muscles and tendons to promote blood circulation collateral dredging, according to modern pharmacological research, the mechanism of action of Radix Tripterygii Wilfordii treatment rheumatoid arthritis mainly is antiinflammatory and immunosuppressant.Caulis Sinomenii in Compendium of Material Medica, state its " can relaxing muscles and tendons to promote blood circulation, the sharp marrow that bonesets, so wind disease weakness, and the card attached undue importance to one thing to the neglect of the other of strength owes to obey informal dress, as seen special effect.Modern pharmacological research shows that its active ingredient has the effect of significant antiinflammatory, analgesia, inhibition immunity.

Above seven flavor medicine is principal agent altogether.In addition, search loose few cloudy, Taiyang channel and limbs wind-cold damp pathogen with Ramulus Cinnamomi, Qiang's Radix Angelicae Pubescentis, Radix Clematidis, BAIYAO flourish muscle, the emergency contraction of relaxing that nourishes blood is accessory drugs altogether.Again with fang-feng powder wind, Radix Stephaniae Tetrandrae removing damp and stopping pain, Herba Asari cold expelling, the warming the lung disease of dispelling, wind-expelling pain-stopping, Rhizoma Atractylodis removing dampness, Radix Polygoni Ciliinerve dissipating blood stasis and clearing away heat; Rhizoma Anemarrhenae nourishing kidney and clearing heat, the Pheretima eliminating stagnation of stimulating the menstrual flow, the Eupolyphaga Seu Steleophaga stasis of blood strengthening bone and muscle of living, the Herba Lycopodii relaxing muscles and tendons and activating QI and blood in the collateral, the Radix Linderae is pleasant, cold expelling, pain relieving, Radix Astragali QI invigorating Kaiyang and Bai Shu air making-up and spleen enlivening, Radix Glycyrrhizae relieving spasm to stop pain coordinating the actions of various ingredients in a prescription are adjuvant drug altogether.The Radix Achyranthis Bidentatae kidney tonifying also can priming be gone into kidney and is just medicine.

Use tincture of the present invention, have 4 persons in following 5 to make a definite diagnosis clinical manifestation by American Rheumatism Association's standard, treatment group 30 examples and matched group 26 examples are treated comparison.Described 5 standards are: 1. morning stiff time 〉=30 minute; 2. articular pain index 〉=10 minute; 3. swollen joint number 〉=2; 4. erythrocyte sedimentation rate＞30mm/h; 5. both hands grip (average) woman＜12Kpa, man＜14.7Kpa.

30 examples are organized in treatment, wherein male 4 examples, women 26 examples, age 23-61 year, average 47 years old, course of disease 1.5-21, average 7.6 years; Early stage 11 examples, mid-terms 16 example, late periods 3 example.

Matched group 26 examples, wherein male 1 example, women 25 examples, age 25-62 year, average 48.5 years old, course of disease 1-19, average 7.4 years, early stage 8 examples, mid-terms 15 example, late periods 3 example.

Oral tincture of the present invention is organized in treatment, matched group ZHENGQINGFENGTONGNING injection 50mg one twice-daily intramuscular injection.

Two groups of clinical 6 observation index compare (X ± S) as shown in the table.

Treatment group (n=30) matched group (n=26)

Observation index

After controlling before controlling after controlling before controlling

Stiff time 2.55 in morning ± 1.54 0.25 ± 0.11 2.45 ± 1.49 0.68 ± 0.45

Pain is closed joint number 11.94 ± 4.83 3.12 ± 0.87 11.49 ± 4.96 6.22 ± 3.21

Arthralgia index 18.1 ± 0.7 3.6 ± 1.8 17.5 ± 1.1 7.5 ± 2.1

Swollen joint several 8.1 ± 2.2 3.0 ± 1.1 7.9 ± 2.0 4.6 ± 1.3

Joint swelling index 18.1 ± 2.5 6.8 ± 1.8 17.5 ± 1.9 7.1 ± 1.9

The average grip 9.5 of both hands ± 2.9 16.4 ± 4.5 10.2 ± 2.8 15.7 ± 2.6

Begin onset time: treatment group 2-4 days, average 2.5 days; Matched group 4-9 days, average 6 days, two groups had significant difference (P＜0.05).

As seen from the above table: treat that 6 indexs all have comparability (P＞0.05) between preceding two groups; The treatment back self contrasts for two groups, and every mark all is significantly improved (P＜0.01), but the improvement of treatment group is more remarkable.

See following four examples in order to model case relatively:

Case 1

Virtuous women 70 years old China one heavy retired veteran cadre of group company of Wu Jin.Suffered from rheumatoid arthritis 6 years, once in Tianjin, the treatment of going to a doctor of ground such as Hubei Hong Hu, the state of an illness does not have and is clearly better oral all kinds of Chinese medicines and Radix Tripterygii Wilfordii preparation inefficacy.

Check: about the stiff 50 minutes time in morning; Erythrocyte sedimentation rate 126mm/h; Rheumatoid factor (+); Anti-O " 1: 800 ", both hands grip 10.8KPa; Left side elbow joint swelling, activity is slightly limited; The swelling of both hands interphalangeal joint is symmetry.

This patient comes me institute to go to a doctor on March 12nd, 96, oral tincture of the present invention, and every day 3 times, each 20-30ml took in one hour after meal.Took continuously 3 months, further consultation on June 20 in 96 year, stiff disappearance in morning, erythrocyte sedimentation rate 14mm/h, the cloudy son of rheumatoid (-), anti-O " 1: 200 ", both hands grip 14.6Kpa, left elbow joint and both hands arthroncus disappear, and be well movable.There was not recurrence in 2 years with examining.

Case 2

The student of 20 years old Heilongjiang Province of woman, Wei Xiao east Qiqihar municipal people's congress.

My this patient institute go to a doctor in August, 95, on inspection: morning stiff time＞1 hour, blood flow 38mm/h, rheumatoid factor (+), anti-O " 1: 600 ", both hands grip 11Kpa, duplex joint, carpal joint and interphalangeal joint swelling, this patient suffered from rheumatoid arthritis 1 year, once treated half a year in First People's Hospital, Qiqihaer City, bad during the characteristic of disease fashion, by the agency of comes my institute's treatment.Oral tincture of the present invention, every day 4 times, each 20ml took 6 months continuously, cooperated acupuncture, massage treatment during this period.Further consultation in March, 96, clinical symptom disappearance, the patient does not have the sense of discomfort, biochemical analysis rheumatoid factor (-), erythrocyte sedimentation rate 19mm/h, each arthroncus disappears, clinical cure.Follow up a case by regular visits to and do not have recurrence in 2 years.

Case 3

People from Longjiang County of 43 years old Heilongjiang Province of Ma Binnan, suffered from rheumatoid arthritis 3 years, once more than a year, heavy when light during the state of an illness, in February, 97, I went to a doctor at institute in Harbin City's oral Chinese medicine treatment, on inspection morning stiff time＞1 hour, rheumatoid factor (+), anti-O is normal, double knee joint, right elbow joint pain and swelling half a year, right elbow joint limitation of activity, erythrocyte sedimentation rate 65mm/h.Oral tincture of the present invention, every day 3 times, each 30ml takes further consultation in 3 months continuously, clinical symptom disappearance, biochemical analysis rheumatoid factor (-), erythrocyte sedimentation rate 11mm/h, double knee joint swelling disappears, idol has pain, and left elbow joint swelling disappears, no pain, and activity is slightly limited.Clinical produce effects.

Case 4

Grandson is man Fructus Pruni mountain area, Longjiang County peasant of 16 years old Heilongjiang Province.Came me institute to go to a doctor the main suit on March 22nd, 96: both hands interphalangeal joint symmetrical swelling companion pain 8 months.Anti-on inspection O " 1: 500 ", erythrocyte sedimentation rate 21mm/h, rheumatoid factor (+).Once obey medicines such as rheumatism panacea, numbness electuary, ZHUIFENGTOUGU WAN and DAHUOLUO DAN, treated no positive effect.

Be diagnosed as rheumatoid arthritis, oral tincture of the present invention, every day 3 times, each 20ml takes further consultation in 3 months continuously.On inspection, anti-O " 1: 400 ", erythrocyte sedimentation rate 11mm/h, rheumatoid factor (-), both hands arthroncus and pain all disappear, clinical cure.

Composition Chinese herbal medicine in the available tincture of the present invention decocts into decoction and takes.Can carry out following plus-minus utilization this moment: the heavy person of brachialgia adds Rhizoma Wenyujin Concisum 10 grams; The obvious person of lumbago and skelalgia can remove Rhizoma Atractylodis, adds Herba Taxilli king 30 grams, and the Cortex Eucommiae 15 grams also increase the weight of Radix Dipsaci, Fructus Psoraleae consumption; The stiff person in the wrong of limbs removes Rhizoma Atractylodis, and Radix Saposhnikoviae is with Semen Coicis 50 grams, Fructus Chaenomelis 12 grams, Bombyx Batryticatus 10 grams; Ridge frame deadlock person distortion person can go Rhizoma Atractylodis to add Rhizoma Cibotii 30 grams; Arthralgia weight person can strengthen Radix Tripterygii Wilfordii, Caulis Sinomenii, Herba Asari consumption, insufficiency of stomach occurs and marks hot person, removes Radix Aconiti Lateralis Preparata, Radix Rehmanniae Preparata, adds the Radix Rehmanniae 30 gram Herba Taxillis and Caulis Lonicerae 30 grams, and strengthens the Herba Dendrobii consumption.

When taking described decoction, should note following and the closely-related main points of clinical efficacy:

1. the consumption of Radix Tripterygii Wilfordii should be followed the principle, particularly medication three days of " from small to large, incremental, increase gradually ", if use half amount, allows the intestines and stomach adapt to, and is the good measure of paving the way for long-term prescription from now on; 2. inactive Radix Tripterygii Wilfordii of RA chronic phase, the Caulis Sinomenii consumption must be increased to 50 grams, could stablize the clinical efficacy of full side; 3. the consumption of Herba Asari also plays critical role in full side.The consumption of Herba Asari can increase gradually to 60 grams, even higher, but the decocting time of whole decoction is more than 40 minutes; 4. the Herba Dendrobii consumption is between 30～60 grams, and when particularly deficiency in origin and excess in superficiality disease appearred in the RA acute stage, its consumption strengthened, Herba Dendrobii yin nourishing benefit is smart, reinforcing YIN-essence tonify deficiency, the benefit of using that must receive eliminating impediment, tonify deficiency, itself and the Rhizoma Atractylodis Macrocephalae protect taste, more can reduce the side effect of medicines such as Radix Tripterygii Wilfordii, Herba Asari.

Claims (4)

1, a kind of tincture for the treatment of rheumatoid arthritis is characterized in that this tincture contains:

The windproof 10 gram rhizoma atractylodis of the celestial 10-15 gram of the stem of noble dendrobium 30-60 gram cultivated land 20-30 gram monkshood 6-12 gram river disconnected 10-15 gram Psoralea corylifolia 10-20 gram thunder godvine 10-45 gram caulis sinomenii 30-60 gram cassia twig 9-15 gram notopterygium root 10-15 gram levisticum 10-15 gram root of herbaceous peony 10-15 kairine lycopodium calvatum 20-30 gram Radix Astragali 30-60 gram root of fangji 10 grams 10 gram bighead atractylodes rhizomes 10 gram root of Chinese wild ginger 10-30 gram earthworms 15 gram reticulate millettias 30 gram radix paeoniae rubrathe 10-15 gram wind-weeds 10 gram ground beetle 6-10 gram roots of three-nerved spicebush 10 grams Radix Glycyrrhizae 10 gram root of bidentate achyranthes 10-15 gram is take 500 gram doses as unit, wherein moisture 500ml and 50 degree high-quality grain wine 2500ml.

2, tincture according to claim 1 is characterized in that this tincture contains:

The celestial 10 gram Herba Lycopodiis of the Herba Dendrobii 50 gram Radix Rehmanniaes Preparata 25 gram Radix Aconiti Lateralis Preparatas 10 gram Radix Dipsaci 15 gram Fructus Psoraleaes 15 Cray Tripterygium wilfordii 15 gram Caulis Sinomeniis 45 gram Ramulus Cinnamomi 12 gram Rhizoma Et Radix Notopterygiis 15 gram Radix Angelicae Pubescentiss 15 gram Radix Paeoniae Albas 15 kairines 30 gram Radixs Astragali 60 gram Radixs Stephaniae Tetrandrae 10 gram Radix Saposhnikoviaes 10 gram Rhizoma Atractylodis 10 gram Rhizoma Atractylodis Macrocephalaes 10 gram Herba Asaris 20 gram Pheretimas 15 gram Caulis Spatholobis 30 gram Radix Paeoniae Rubra 15 gram Rhizoma Anemarrhenaes 10 gram Eupolyphaga Seu Steleophagas 10 gram Radixs Linderae 10 gram Radix Glycyrrhizaes 10 gram Radix Achyranthis Bidentataes 15 grams is a unit with 500 gram doses, wherein moisture 500ml and 50 degree high-quality grain wine 2500ml.

3, tincture according to claim 2 is characterized in that this tincture also contains:

Radix Angelicae Sinensis 25 gram Radix Salviae Miltiorrhizaes 25 gram Herba Epimedii 30 gram Nidus Vespae 15 gram water 500ml

4, a kind of method for preparing claim 1 or 2 or 3 described tinctures is characterized in that the step that this method comprises is:

1. each raw material in claim 1 or the 2 or 3 described tinctures is broken into 80 purpose coarse powder, and mixes by described proportioning;

2. be that unit is distributed into bag with husky cloth with said mixture with 500 grams;

3. every bag of mixture after 1 hour, is decocted the 300ml that takes concoction with the cold water soak of 1500ml, and then add 1000ml cold water and carry out second time and decoct, 200ml takes concoction;

4. the medicine after will decocting the 500ml medicine juice that takes out after two times and decocting extracting juice is together put into glass container, pours 50 degree high-quality grain wine 2500ml soak medicines into, sealed glass container;

5. soak the supernatant that takes out after 10 days in the glass container and divide the bottle encapsulation, every bottle is 250ml.