CN104644866A - Traditional Chinese medicine for treating recurrent oral ulcer - Google Patents

Abstract

The invention relates to a traditional Chinese medicine for treating recurrent oral ulcer. The traditional Chinese medicine is prepared from the following raw medicinal materials in parts by weight: 12 parts of folium isatidis, 9 parts of hedyotis diffusa, 6 parts of radix scrophulariae and 5 parts of honey-fried licorice root. Clinical experiments prove that the traditional Chinese medicine provided by the invention can be used for safely and effectively treating recurrent oral ulcer.

Description

A kind of Chinese medicine being used for the treatment of recurrent oral ulceration

Technical field

The present invention relates to a kind of Chinese medicine, be specifically related to a kind of Chinese medicine being used for the treatment of recurrent oral ulceration.

Background technology

Recurrent oral ulceration refers to agnogenio, recurrent exerbation, has the isolated circle of its self limiting or oval ulcer, also known as recurrent aphtha.

Modern medicine is thought, first recurrent oral ulceration has very close relationship with immunity.Some patients are immunodeficiency, and some patients then show as autoimmune response; Next has relation with heredity, and in clinical, the morbidity of recurrent oral ulceration, has obvious Family inherited inclination, if father and mother one side or in many ways suffer from recurrent oral ulceration, their children are just easier than common people ill; In addition, the outbreak of recurrent oral ulceration, also relevant with some diseases or symptom, such as digestive system disease: gastric ulcer, duodenal ulcer, chronic or chronic persistent hepatitis, colitis etc., in addition monophagia, dyspepsia, generate heat, do not have enough sleep, overtired, operating pressure large, the change of menstrual cycle etc.Along with one or more factors active, alternately occur that immunity of organisms declines, cause the frequent outbreak of recurrent oral ulceration.

Medical material present Research involved in the present invention is as follows:

Folium Isatidis [source] this product is the dried leaves of cruciferae isatis Isatis indigotica Fort..In the summer, divide in season in autumn two and gather for 2 ~ 3 times, removing impurity, dries.[process of preparing Chinese medicine] removing impurity, slightly washes, chopping, dry.[nature and flavor] are bitter, cold.[return through] GUIXIN, stomach warp.[function cures mainly] heat-clearing and toxic substances removing, blood cooling and ecchymoses removing.Join the army for pathogenic warmth, unconsciousness due to high fever, sends out speckle dermexanthesis, jaundice, hematodiarrhoea, mumps, sore throat, erysipelas, carbuncle.[usage and dosage] 9 ~ 15g.[storage] puts aeration-drying place, mildew-resistant.

Herba Hedyotidis Diffusae [source] this product is the herb of Rubiaceae plants of Hedyotis Herba Hedyotidis Diffusae Hedyotis diffusa Willd. [Oldenlandia diffusa (Willd.) Roxb.].Xia Qiu gathers, and cleans, using fresh herb or dry.[nature and flavor] are sweet, light, cool.[return through] enters stomach, large intestine, small intestine meridian.[function cures mainly] heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain.For acute appendicitis (appendicitis), furuncle toxic swelling, jaundice due to damp-heat, the diseases such as dysuria; Furuncle carbuncle is controlled in external, venom.[usage and dosage] 3 ~ 12g.

Radix Scrophulariae [source] this product is the dry root of goatweed Radix Scrophulariae Scrophularia ningpoensis Hemsl..Excavate when winter, stem and leaf was withered.Removing rhizome, plumelet, fibrous root and silt, shine or be dried to half-dried, stacking 3 ~ 6 days, repeatedly for several times to dry.The residual rhizome of [process of preparing Chinese medicine] removing and impurity, clean, run through, shave, dry; Or microvesicle, steam thoroughly, slightly dry in the air, shave, dry.[nature and flavor] are sweet, bitter, salty, are slightly cold.[return through] returns lung, stomach, kidney channel.[function cures mainly] removing heat from blood YIN nourishing, eliminating fire and detoxication.For consumption of YIN caused by febrile disease, crimson tongue excessive thirst, maculae caused by violent heat pathogen, constipation is hindered in Tianjin, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus.[usage and dosage] 6 ~ 15g.[attention] should not with Rhizoma et radix veratri (Radix Rhizoma Veratri) with using.[storage] puts dry place, and mildew-resistant is mothproof.

Radix Glycyrrhizae Preparata [source] this product is the Preparation process product of Radix Glycyrrhizae.[nature and flavor] are sweet, flat.[return through] GUIXIN, lung, spleen, stomach warp.[function cures mainly] spleen reinforcing stomach function regulating, Yiqi and vein recovery.For weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse.[usage and dosage] 1.5 ~ 9g.[attention] should not with Radix Euphorbiae Pekinensis, Flos Genkwa, Radix Kansui with using.[storage] puts aeration-drying place, mothproof.

Summary of the invention

The present invention aims to provide a kind of Chinese medicine being used for the treatment of recurrent oral ulceration, by selecting suitable medical material and proportioning thereof, reaches the object of safe and effective healing recurrent oral ulceration.

In order to achieve the above object, the present invention is by the following technical solutions:

Be used for the treatment of a Chinese medicine for recurrent oral ulceration, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Folium Isatidis 12 parts, Herba Hedyotidis Diffusae 9 parts, Radix Scrophulariae 6 parts, Radix Glycyrrhizae Preparata 5 parts.

Inventor thinks that this disease belongs to the traditional Chinese medical science " aphtha, mouth infections, aphtha " category.Ming Dynasty Xue oneself mentions in " ability to speak class want ": " deficiency-cold in middle-JIAO, part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels YIN-fire, individual caused by the change of disease.When controlling it respectively." clearly propose upper, middle and lower three burnt deficiency and excess cold and heat and can cause aphtha, and each zang-fu differentiation pathological changes can the change of disease mutually.Inventor thinks: its cause of disease has because of flaming up of heart-fire, fumigates in mouth; Have because of the raw expectorant of spleen-heat, phlegm-fire is tied mutually, on gather in mouth, have because taste two are empty, asthenic fire disturbed in mouth.Folium Isatidis in we, heat-clearing and toxic substances removing, Radix Scrophulariae, Herba Hedyotidis Diffusae heat clearing and blood cooling detoxify, tonify deficiency QI invigorating in Radix Glycyrrhizae Preparata tune.All medicines share, and play heat clearing away QI invigorating altogether, effect for the treatment of oral ulcer.Therefore assembly is our.

Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:

1, physical data

Collect recurrent oral ulceration 120 example in March ,-2013 in October, 2012, be divided into 2 groups at random.Treatment group 60 example, man 28 example, female 32 example, age 19-63 year, 41.5 years old mean age, course of disease 1-5, average course of disease 2.5 years, slightly (oral mucosa erythema is divided into according to the weight of the course of disease, have >=1 aphtha, ulcer area <8mm2), moderate (ulcer area 8-15mm2), severe (ulcer area > 15mm2), its mild or moderate 12 example, moderate 42 example, severe 6 example.Matched group 60 example, man 27 example, female 33 example, age 20-63 year, 43.5 years old mean age, course of disease 0.5-6, average course of disease 2 years, its mild or moderate 13 example, moderate 40 example, severe 7 example.Two groups of patients do not have significant difference in sex, age, the course of disease and coincident with severity degree of condition, have comparability.

2, Therapeutic Method

Treatment group: the decoct that oral the present invention obtains according to specific embodiment 1, every day 3 times 7 days was 1 course for the treatment of.

Matched group: oral cavity ulcer powder applies in local in oral ulcer place, and Tongrentang Pharmaceutical Factory, Beijing TongrenTang Co., Ltd produces, and 3g/ bottle, every day 3 times 7 days was 1 course for the treatment of.

3, curative effect determinate standard:

After treating 1 course for the treatment of, follow up a case by regular visits to half a year, recovery from illness: patient's oral ulcer all heals, and follows up a case by regular visits in 6 months, does not recur;

Effective: patient's oral ulcer all heals, follow up a case by regular visits in 6 months, do not recur, or recurrent interval time obviously extends, the ulcer order of severity alleviates to some extent;

Effective: patient's oral ulcer has and obviously alleviates, and follow up a case by regular visits in 6 months, recurrent interval time obviously extends, and the ulcer order of severity alleviates to some extent;

Invalid: patient's oral ulcer, without improvement, is followed up a case by regular visits in 6 months, recurrent interval time is without change, and the ulcer order of severity does not alleviate.

Total effective rate=(recovery from illness number of cases+effective number of cases+effectively number of cases)/total number of cases × 100%

4, result

Treat 1 course for the treatment of and follow up a case by regular visits to 6 months, treatment group recovery from illness 46 example, effective 12 examples, effective 2 examples, invalid 0 example, total effective rate is 1 case relapsed in 100%, 6 months, and relapse rate is 1.7%; Matched group cures 29 examples, effective 11 examples, effective 9 examples, invalid 11 examples, and total effective rate is 81.7%, and recurrence 12 example, relapse rate is 20%.Treatment group total effective rate is significantly higher than matched group, P<0.05; The relapse rate for the treatment of group significantly lower than matched group, P<0.05.

Visible, the medicine that the present invention obtains can safe and effective treatment recurrent oral ulceration, has promotional value.

Detailed description of the invention

In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.

Specific embodiment 1

Take: Folium Isatidis 12 grams, Herba Hedyotidis Diffusae 9 grams, Radix Scrophulariae 6 grams, Radix Glycyrrhizae Preparata 5 grams; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 grams, must meet the decoct of adult normal's one day consumption.

Be used for the treatment of recurrent oral ulceration.Oral, every bu morning, noon and afternoon take for three times.

Specific embodiment 2

Take: Folium Isatidis 12 grams, Herba Hedyotidis Diffusae 9 grams, Radix Scrophulariae 6 grams, Radix Glycyrrhizae Preparata 5 grams; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, must meet the powder of adult normal's one day consumption.

Be used for the treatment of recurrent oral ulceration.Oral, daily once.

Specific embodiment 3

Take: Folium Isatidis 12 grams, Herba Hedyotidis Diffusae 9 grams, Radix Scrophulariae 6 grams, Radix Glycyrrhizae Preparata 5 grams; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, must meet the capsule of adult normal's one day consumption.

Be used for the treatment of recurrent oral ulceration.Oral, every bu is taken for twice sooner or later.

Claims (1)

1. be used for the treatment of a Chinese medicine for recurrent oral ulceration, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Folium Isatidis 12 parts, Herba Hedyotidis Diffusae 9 parts, Radix Scrophulariae 6 parts, Radix Glycyrrhizae Preparata 5 parts.