CN103495091A - Traditional Chinese medicine immune stimulant for preventing Eimeria tenella infections - Google Patents
Traditional Chinese medicine immune stimulant for preventing Eimeria tenella infections Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine immune stimulant for preventing Eimeria tenella. The active ingredient of the traditional Chinese medicine immune stimulant comprises caulis spatholobi, sweet wormwood, rubia cordifolia, humifuse euphorbia herb, honeysuckle, belvedere fruit, garlic, java brucea fruit, the root of Chinese pulsatilla, Chinese dates, lalang grass rhizome, lantana camara, herba taxilli, sargentg loryvine, urena lobata, peach juvenile branchlet, hypericum ascyron, gentiana macrophylla, radix stemonae, semen pharbitidis, cortex ailanthi, hempleaf negundo chastetree leaf, scutellaria baicalensis and sophora flavescens. The traditional Chinese medicine immune stimulant is low in drug resistance and few in drug residue, does not have a toxic and side effect, and has a good prevention effect in the aspect of preventing an Eimeria tenella disease.
Description
Technical field
The present invention relates to the Chinese medicine technical field, relate in particular to the Chinese medicine immune formulation for preventing Eimeria Tenella to infect.
Background technology
It is by the caused a kind of serious parasitic disease that parasitizes the Intestinum Gallus domesticus road of one or more Eimeria coccidiosiss that Eimeria Tenella infects, this disease M & M is all high, sickness rate is high to 50%～70%, mortality rate is 20%～30%, can reach 80% when serious, bring huge economic loss to poultry husbandry in world wide.Chicken coccidiosis is serious to aviculture harm, is regarded as in poultry farming expending the highest parasitic disease.This disease generally is mainly in spring or summer, but in intensive chicken farm, all can occur throughout the year at present, to aviculture, causes huge loss.
In current research, main still by following three kinds of approach control chicken coccidiosis: as 1) to strengthen feeding and management, environment purification; 2) application virulent strain, attenuated strain, multidrug resistant strain are manufactured vaccine and are used for preventing chicken coccidiosis, but poor effect; 3) clinically the medical treatment chicken coccidiosis be still main by way of, but due to the life cycle of chicken coccidiosis complexity and the medicine abuse of old medicine particularly, caused serious drug resistance problem, meanwhile some chicken farm is solved the drug resistance problem by escalated dose and has been brought again food-safety problem.The appearance of drug resistance and how to prevent and treat two great difficult problems that primary disease has become current poultry husbandry, therefore must drop into a large amount of funds and time exploitation wide spectrum, efficient, metabolism is fast, the novel coccidiosis medicine of economy and low-residual.
Now apply clinically more preventive usage as monensin, Maduramicin etc.; but because the raiser is inadequate to the consciousness of medicament protection; the abuse of medicine causes the therapeutic effect that exerts an influence of drug resistance; therefore develop a kind of new drug and compel as pressing as a fire singeing one's eyebrows, the foster family of reinforcement simultaneously also is very important to the reasonable use of medicine.
Research shows that the traditional Chinese medicine of China has a large amount in variety and has the anticoccidial effect, and with respect to chemical synthetic drug and antibiotic, it is low or have no side effect that Chinese medicine has toxic and side effects, the characteristics such as noresidue and difficult generation drug resistance, current domestic control coccidiosis still be take chemoprophylaxis as main, high dose continues to use Western medicine easily to produce drug resistance, toxic and side effects, drug residue, to the chicken body, meat, egg and sanitarian harm are increasing, and that Chinese herbal medicine has a drug resistance is low, drug residue is few, improve the incomparable advantages of Western medicine such as immunity of organisms and the growth of promotion animal body.
Summary of the invention
Technical problem to be solved by this invention is to provide that a kind of its drug resistance is low for preventing the Chinese medicine immune formulation of Eimeria Tenella disease, and drug residue is few, has no side effect, and at the prevention Eimeria Tenella, has good preventive effect aspect sick.
For solving the problems of the technologies described above, the invention provides a kind ofly for preventing the Chinese medicine immune formulation of Eimeria Tenella disease, its crude drug comprises Caulis Spatholobi, Herba Artemisiae Annuae, Radix Rubiae, Herba Euphorbiae Humifusae, Flos Lonicerae, the Fructus Kochiae, Bulbus Allii, Fructus Bruceae, the Radix Pulsatillae, Fructus Jujubae, Rhizoma Imperatae, Folium Lantanae Camarae, Herba Taxilli, Caulis Sargentodoxae, Radix Urenae Lobatae, Ramulus Persicae, Herba Hyperici, Radix Gentianae Macrophyllae, the Radix Stemonae, Semen Pharbitidis, Cortex Ailanthi, Folium Viticis Negundo, Radix Scutellariae and Radix Sophorae Flavescentis.
Wherein, in described Chinese medicine immune formulation, the weight of each crude drug is respectively:
Caulis Spatholobi 35g～45g, Herba Artemisiae Annuae 25g～35g, Radix Rubiae 30g～40g, Herba Euphorbiae Humifusae 20g～30g, Flos Lonicerae 65g～75g, Fructus Kochiae 40g～50g, Bulbus Allii 35g～45g, Fructus Bruceae 35g～45g, Radix Pulsatillae 40g～50g, Fructus Jujubae 30g～40g, Rhizoma Imperatae 25g～35g, Folium Lantanae Camarae 25g～35g, Herba Taxilli 35g～45g, Caulis Sargentodoxae 30g～40g, Radix Urenae Lobatae 25g～35g, Ramulus Persicae 25g～35g, Herba Hyperici 40g～50g, Radix Gentianae Macrophyllae 25g～35g, Radix Stemonae 30g～40g, Semen Pharbitidis 25g～35g, Cortex Ailanthi 30g～40g, Folium Viticis Negundo 25g～35g, Radix Scutellariae 45g～55g and Radix Sophorae Flavescentis 35g～45g.
Wherein, in described Chinese medicine immune formulation, the weight of each crude drug is respectively:
Caulis Spatholobi 35g～40g, Herba Artemisiae Annuae 25g～30g, Radix Rubiae 30g～35g, Herba Euphorbiae Humifusae 20g～25g, Flos Lonicerae 65g～70g, Fructus Kochiae 40g～45g, Bulbus Allii 35g～40g, Fructus Bruceae 35g～40g, Radix Pulsatillae 45g～50g, Fructus Jujubae 35g～40g, Rhizoma Imperatae 30g～35g, Folium Lantanae Camarae 30g～35g, Herba Taxilli 40g～45g, Caulis Sargentodoxae 35g～40g, Radix Urenae Lobatae 30g～35g, Ramulus Persicae 30g～35g, Herba Hyperici 45g～50g, Radix Gentianae Macrophyllae 30g～35g, Radix Stemonae 35g～40g, Semen Pharbitidis 30g～35g, Cortex Ailanthi 35g～40g, Folium Viticis Negundo 30g～35g, Radix Scutellariae 50g～55g and Radix Sophorae Flavescentis 40g～45g.
The present invention also provides the preparation method of above-mentioned Chinese medicine immune formulation, is specially:
The first step, each crude drug component in described Chinese medicine immune formulation is mixed in proportion, obtain mixture, add the water with respect to 2 ~ 4 times of mixture qualities, decoct and process 1～3 hour, decoction liquor is filtered to concentration, obtain mastic, the relative density of described mastic is 1.15 ~ 1.18 (65 ℃);
Second step, the ethanol that is 65% ~ 75% by the determining alcohol that adds in the mastic of acquisition with respect to 3～5 times of first step mixture qualities, stirred 20 minutes ~ 40 minutes, 0～4 ℃ of lower cold preservation 1 ~ 2 hour, filter, decompression recycling ethanol, obtain and get dry extract, be ground into 100 orders ~ 200 purpose powder, obtain the Chinese medicine immune formulation.
It is a kind of for preventing the feedstuff of Eimeria Tenella disease that the present invention also provides, and its raw material comprises: Semen Tritici aestivi, bean cake, bone meal, rapeseed meal, dalcium biphosphate, vitamin E, vitamin K, pantothenic acid, lysine, methionine, threonine and above-mentioned for preventing the Chinese medicine immune formulation of Eimeria Tenella disease.
Wherein, in described feedstuff, each constituent content can be 9kg ~ 11kg Semen Tritici aestivi, 2kg ~ 3kg bean cake, the bone meal of 500g ~ 600g, 1kg ~ 2kg rapeseed meal, the dalcium biphosphate of 300g ~ 400g, the methionine of the pantothenic acid of the vitamin E of 100g ~ 200g, the vitamin K of 100g ~ 200g, 150g ~ 250g, the lysine of 100g ~ 200g, 100g ~ 200g, the threonine of 100g ~ 200g and the Chinese medicine immune formulation of 1kg ~ 2kg.
The present invention also provides the preparation method of above-mentioned feedstuff, and it comprises:
The first step, each crude drug component in described Chinese medicine immune formulation is mixed in proportion, obtain mixture, add the water with respect to 2 ~ 4 times of mixture qualities, decoct and process 1～3 hour, decoction liquor is filtered to concentration, obtain mastic, the relative density of described mastic is 1.15 ~ 1.18 (65 ℃);
Second step, the ethanol that is 65% ~ 75% by the determining alcohol that adds in the mastic of acquisition with respect to 3～5 times of first step mixture qualities, stirred 20 minutes ~ 40 minutes, 0～4 ℃ of lower cold preservation 1 ~ 2 hour, filter, decompression recycling ethanol, obtain and get dry extract, be ground into 100 orders ~ 200 purpose powder, obtain the Chinese medicine immune formulation;
The 3rd step, the Chinese medicine immune formulation that Semen Tritici aestivi, bean cake, bone meal, rapeseed meal, dalcium biphosphate, vitamin E, vitamin K, pantothenic acid, lysine, methionine, threonine and second step are obtained mixes, pour in spraying machine, in spraying machine, water temperature is modulated at 60 ~ 70 ℃, open aerosol apparatus, stir 1 ~ 2 minute, continue to be warming up to 90 ℃ and complete expanded;
The 4th step, add the water with respect to 0.1 ~ 0.3 times of its quality by the product after expanded, puts into granulator and granulate, and the granulator electric current is 175A;
The 5th step, dry after granulating, baking temperature is 105 ℃, drying time 15 ~ 25min; Then cooling, the cooling blower electric current is 31A, and packing, obtain described feedstuff.
Beneficial effect of the present invention:
Provided by the invention for preventing the Chinese medicine immune formulation of Eimeria Tenella disease, its drug resistance is low, and drug residue is few, has no side effect, and aspect prevention Eimeria Tenella disease, has good preventive effect.
The specific embodiment
The invention provides a kind ofly for preventing the Chinese medicine immune formulation of Eimeria Tenella disease, its crude drug comprises Caulis Spatholobi, Herba Artemisiae Annuae, Radix Rubiae, Herba Euphorbiae Humifusae, Flos Lonicerae, the Fructus Kochiae, Bulbus Allii, Fructus Bruceae, the Radix Pulsatillae, Fructus Jujubae, Rhizoma Imperatae, Folium Lantanae Camarae, Herba Taxilli, Caulis Sargentodoxae, Radix Urenae Lobatae, Ramulus Persicae, Herba Hyperici, Radix Gentianae Macrophyllae, the Radix Stemonae, Semen Pharbitidis, Cortex Ailanthi, Folium Viticis Negundo, Radix Scutellariae and Radix Sophorae Flavescentis.
Further preferably, described Chinese medicine immune formulation only is prepared from by the above-mentioned raw materials medicine.
In described Chinese medicine immune formulation, the weight of each crude drug is respectively:
Caulis Spatholobi 35g～45g, Herba Artemisiae Annuae 25g～35g, Radix Rubiae 30g～40g, Herba Euphorbiae Humifusae 20g～30g, Flos Lonicerae 65g～75g, Fructus Kochiae 40g～50g, Bulbus Allii 35g～45g, Fructus Bruceae 35g～45g, Radix Pulsatillae 40g～50g, Fructus Jujubae 30g～40g, Rhizoma Imperatae 25g～35g, Folium Lantanae Camarae 25g～35g, Herba Taxilli 35g～45g, Caulis Sargentodoxae 30g～40g, Radix Urenae Lobatae 25g～35g, Ramulus Persicae 25g～35g, Herba Hyperici 40g～50g, Radix Gentianae Macrophyllae 25g～35g, Radix Stemonae 30g～40g, Semen Pharbitidis 25g～35g, Cortex Ailanthi 30g～40g, Folium Viticis Negundo 25g～35g, Radix Scutellariae 45g～55g and Radix Sophorae Flavescentis 35g～45g.
Further, in described Chinese medicine immune formulation, the weight of each crude drug is respectively:
Caulis Spatholobi 35g～40g, Herba Artemisiae Annuae 25g～30g, Radix Rubiae 30g～35g, Herba Euphorbiae Humifusae 20g～25g, Flos Lonicerae 65g～70g, Fructus Kochiae 40g～45g, Bulbus Allii 35g～40g, Fructus Bruceae 35g～40g, Radix Pulsatillae 45g～50g, Fructus Jujubae 35g～40g, Rhizoma Imperatae 30g～35g, Folium Lantanae Camarae 30g～35g, Herba Taxilli 40g～45g, Caulis Sargentodoxae 35g～40g, Radix Urenae Lobatae 30g～35g, Ramulus Persicae 30g～35g, Herba Hyperici 45g～50g, Radix Gentianae Macrophyllae 30g～35g, Radix Stemonae 35g～40g, Semen Pharbitidis 30g～35g, Cortex Ailanthi 35g～40g, Folium Viticis Negundo 30g～35g, Radix Scutellariae 50g～55g and Radix Sophorae Flavescentis 40g～45g.
Further preferred, in described Chinese medicine immune formulation, the weight of each crude drug is respectively:
Caulis Spatholobi 40g, Herba Artemisiae Annuae 30g, Radix Rubiae 35g, Herba Euphorbiae Humifusae 25g, Flos Lonicerae 70g, Fructus Kochiae 45g, Bulbus Allii 40g, Fructus Bruceae 40g, Radix Pulsatillae 45g, Fructus Jujubae 35g, Rhizoma Imperatae 30g, Folium Lantanae Camarae 30g, Herba Taxilli 40g, Caulis Sargentodoxae 35g, Radix Urenae Lobatae 30g, Ramulus Persicae 30g, Herba Hyperici 45g, Radix Gentianae Macrophyllae 30g, Radix Stemonae 35g, Semen Pharbitidis 30g, Cortex Ailanthi 35g, Folium Viticis Negundo 30g, Radix Scutellariae 50g and Radix Sophorae Flavescentis 40g.
The pharmacology of described each crude drug is as follows:
Caulis Spatholobi: latin name
spatholobi Caulis, bitter in the mouth, sweet, warm in nature, enter liver, kidney channel, blood vessel dilating is arranged, enrich blood and invigorate blood circulation, regulating menstruation, the effect of relaxing muscles and tendons and activating QI and blood in the collateral, platelet aggregation is had to obvious inhibitory action, promote animal kidney and the total phosphorus metabolism in uterus, be mainly used in treating the menoxenia that blood deficiency has silt, limbs pain is meciless, the cards such as soreness of the waist and knees, pain.
Herba Artemisiae Annuae: latin name
artemisiae Annuae Herba, bitter in the mouth, suffering, cold in nature, return liver, gallbladder meridian, there is deficiency-heat clearly thoroughly, removing heat from blood is except steaming, and except steaming, the effect of preventing the attack (or recurrence) of malaria, cure mainly the pathogenic summer-heat heating, fever due to yin deficiency, night fever abating at dawn, hectic fever due to YIN-deficiency consumptive fever, malaria cold and heat, the cards such as jaundice due to damp-heat.
Radix Rubiae: cold in nature, bitter in the mouth, return Liver Channel, effect: cooling blood for hemostasis; Blood circulation promoting and blood stasis dispelling, cards such as curing mainly heat in blood spitting of blood, haematemesis, epistaxis, hematuria, have blood in stool, metrorrhagia, amenorrhea, postpartum stagnation stomachache, traumatic injury, rheumatic arthralgia, jaundice, carbuncle sore, hemorrhoid are swollen.
Herba Euphorbiae Humifusae: acrid in the mouth, property is put down, return liver, large intestine channel, effect with heat-clearing and toxic substances removing, cooling blood for hemostasis, damp-heat dysentery, urine leaching pain, jaundice, the various treatments that go out blood disorder etc., Herba Euphorbiae Humifusae has effect antibacterial or sterilization to staphylococcus aureus, Hemolytic streptococcus, diphtheria corynebacterium, escherichia coli, dysentery bacterium etc.
Flos Lonicerae: sweet in the mouth, cold in nature, enter the heart, lung, stomach, large intestine channel, the effect of heat-clearing and toxic substances removing is arranged, holding concurrently can eliminating pathogenic heat from blood to cure dysentery.Be mainly used in affection due to external wind and heat, the epidemic febrile disease pyretic toxicity is contained, or epidemic febrile disease is from the beginning of pathogenic heat still at the part of the body cavity above the diaphragm housing the heart and lungs and when not descending; Pyretic toxicity dysentery, stool hematochezia; The fever disease in summer card; The carbuncle sore that pyretic toxicity gathers is from the beginning of, inflammation heat person of swelling and ache etc., Flos Lonicerae has antipyretic effect preferably, the energy antiinflammatory, what control inflammation oozes out and inflammatory hyperplasia, can promote leukocytic phagocytic function, multiple pyococcus and pathogenic entero becteria are had to stronger bacteriostasis, comprise staphylococcus, Hemolytic streptococcus, meningococcus, dysentery bacterium, Bacillus typhi, bacillus pyocyaneus, tubercule bacillus etc., the pyretic toxicity that Flos Lonicerae is divided QI and blood battalion is all effective, and broad-spectrum antibacterial action is arranged.
The Fructus Kochiae: latin name
kochiae Fructus, cold in nature, acrid in the mouth, hardship, enter kidney, urinary bladder channel, has clearing away heat-damp and promoting diuresis, and the effect of dispelling wind for relieving itching cures mainly the cards such as difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.
Bulbus Allii: warm in nature, acrid in the mouth is flat; Enter spleen, stomach, lung meridian, have that warming middle-JIAO helps digestion, the effect of row stagnant gas, warming the spleen and stomach, removing food stagnancy, removing toxic substances, parasite killing, cure mainly eating accumulation, coldness and pain in the epigastrium, edema distension, have loose bowels, the cards such as dysentery, malaria, pertussis, swollen ulcer drug, white bald tinea skin ulcer, snake bite and insect sting and ancylostome, pinworm.
Fructus Bruceae: latin name
bruceae Fructus, bitter in the mouth, cold in nature, return large intestine channel, Liver Channel, there is heat-clearing and toxic substances removing, dysentery relieving, preventing the attack (or recurrence) of malaria, the effect of corrosion wart, cure mainly dysentery, malaria; The cards such as external treatment wart, clavus.
The Radix Pulsatillae: bitter in the mouth, cold in nature, enter stomach, large intestine channel, there is heat-clearing and toxic substances removing, the effect of eliminating pathogenic heat from blood to cure dysentery, being mainly used in gastrointestinal has damp and hot stagnant heating stomachache, dysentery pus and blood, the cards such as tenesmus; Hematodiarrhoea hematochezia better effects if to the large intestine heat in blood, have inhibitory action to dysentery bacterium, Bacillus typhi, bacillus subtilis, escherichia coli, Staphyloccocus aureus.
Fructus Jujubae: latin name
jujubae Fructus,sweet in the mouth, warm in nature, return spleen, stomach warp, there is the spleen reinforcing stomach function regulating, supplementing QI for promoting the production of body fluid, adjust battalion to defend, and separates the effect of poison of drug, cures mainly the insufficiency of stomach lack of appetite, the weak loose stool of spleen, qi-blood-body fluid deficiency, disharmony of nutrient QI with defensive QI, severe palpitation.The hot-tempered card that waits of married woman's stolen goods.
Rhizoma Imperatae: sweet in the mouth, cold in nature, enter lung, stomach, urinary bladder channel, the effect of cooling blood for hemostasis, clearing away heat and promoting diuresis is arranged, be mainly used in haematemesis, hemoptysis that the lung stomach has accumulated heat; Damp invasion of lower energizer pents up the hematuria of bladder; Calentura excessive thirst taking fluids profusely; Gastropyretic vomiting; The cards such as jaundice due to damp-heat.
Folium Lantanae Camarae: bitter in the mouth, micro-sweet, cool in nature, there is heat clearing away, the effect of hemostasis, cure mainly the pulmonary tuberculosis hemoptysis, and stomachache is vomited and diarrhoea, eczema, the cards such as pudendal pruritus.
Herba Taxilli: bitter in the mouth, sweet, property is flat, enters liver, kidney channel, effect with invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit, for the soreness of waist pain due to deficiency of the liver and kindey, the muscles and bones flaccidity is soft, the foot and knee being feeble, deficiency of the liver and kindey, essence and blood is empty to be lost, the frequent fetal movement of liability to abortion, the cards such as waist abdomen pain.
Caulis Sargentodoxae: bitter in the mouth, property is flat, returns liver, large intestine channel, has the eliminating carbuncle of relieving internal heat, promoting blood circulation to remove obstruction in the collateral, the effect of wind dispelling insecticide, cure mainly acute and chronic appendicitis, rheumatic arthralgia, bloody dysentery, stranguria with blood, menoxenia, infantile malnutrition, worm pain, the cards such as injury from falling down.
Radix Urenae Lobatae: sweet in the mouth, light, property is flat, enters the heart, lung meridian, has expelling wind and removing dampness, and the effect of heat-clearing and toxic substances removing, cure mainly cold, fever, rheumatic arthralgia, dysentery, edema, leucorrhea, spit blood, carbuncle, traumatic hemorrhage, venom, acute infantile convulsion, tetanus, asthma, the cards such as stomachache puerperal exposure to wind.
Ramulus Persicae: latin name
persicae Ramulus, bitter in the mouth, property is flat, and GUIXIN, Liver Channel, have promoting blood circulation to restore menstrual flow, and the effect of removing toxic substances parasite killing, for trusted subordinate's twinge, rheumatic arthralgia, the cards such as traumatic injury.
Herba Hyperici: bitter in the mouth, cold in nature, there is cooling blood for hemostasis, promoting blood flow to regulate menstruation, the effect of eliminating fire and detoxication, cure mainly heat in blood and spit blood, and hematuria is had blood in stool, metrorrhagia, traumatic injury, traumatic hemorrhage, menoxenia, dysmenorrhea, agalactia, the cards such as liver-fire headache, jaundice, scald, eczema, impetigo, venom.
Radix Gentianae Macrophyllae: latin name
gentianae Macrophyllae Radix, acrid in the mouth, hardship, cold nature, return stomach warp, Liver Channel, gallbladder meridian, has wind-damp dispelling, the relaxing muscles and tendons network, the effect of clearind deficient heat, cure mainly rheumatic arthralgia, the contracture of muscle arteries and veins, joint is ached, afternoon fever, the cards such as infantile malnutrition heating.
The Radix Stemonae: sweet in the mouth, hardship, slightly warm in nature, enter lung meridian, there is nourishing the lung to arrest cough, the effect of delousing parasite killing, Radix Stemonae temperature embellishes but not dry, and property is kept and is not walked, the merit that the using pungent drugs for dispersion and bitter drugs for purgation sending down the abnormal ascending QI is arranged again, be mainly used in new all coughing for a long time, especially be suitable for consumptive fever chronic cough person, modern for preventing and treating the cough of chronic bronchitis, the dry cough of pulmonary tuberculosis, the cards such as pertussis.
Semen Pharbitidis: latin name
semen Pharbitidis, cold in nature, bitter in the mouth, return lung meridian, kidney channel, large intestine channel, has removing fluid-retention by purgation, therapeutic method to keep the adverse QI flowing downwards expectorant, and the effect except long-pending parasite killing, cure mainly edema ascites, the beriberi generalized edema with distention of the chest and abdomen, phlegm retention is breathed with cough, complete works of constipated, dyspepsia malnutrition due to parasitic infestation, swollen ulcer drug.
Cortex Ailanthi: bitter in the mouth, puckery, cold in nature, enter large intestine, stomach, Liver Channel, there is heat clearing and damp drying, the astringing intestine to stop diarrhea leukorrhagia stopping, hemostasis, the effect of parasite killing, for damp-heat dysentery, the chronic diarrhea chronic dysentery, metrorrhagia, have blood in stool, hemorrhoid hematochezia, leukorrhagia, the cards such as discharging fresh blood stool.
Folium Viticis Negundo: latin name
viticis NegundoFolium, acrid in the mouth; Bitter; Property is put down, and returns lung meridian, has the removing dampness of inducing sweat, eliminating phlegm and relieving asthma; Removing toxic substances, expelling pathogenic wind from the body surface, dehumidifying, parasite killing, the effect of pain relieving, cure mainly Common Cold, cough, asthma; Stomachache; Stomachache; The heat-damp in summer dysentery; Beriberi swelling; The rubella pruritus; Tinea pedis; Acute mastitis swells and ache; The cards such as snake bite and insect sting.
Radix Scutellariae: latin name
scutellariae Radix, bitter in the mouth, cold in nature, enter the heart, lung, stomach, gallbladder, large intestine channel, and heat clearing and damp drying is arranged, and eliminating fire and detoxication is antiabortive, and the effect of hemostasis is mainly used in diarrhoea, dysentery, jaundice, pyretic stranguria due to damp and hot; The cough due to lung-heat, thirsty pharyngalgia, also can be used for excessive fetal movement due to heat in pregnancy, and the pyretic toxicity pathogenic fire is invaded the swollen card of carbuncle sore poison of excessive skin.
Radix Sophorae Flavescentis: bitter in the mouth, cold in nature, enter liver, kidney, large intestine, small intestinal, bladder, heart channel, there is heat clearing and damp drying, the effect of wind dispelling insecticide, cure mainly damp-heat dysentery, discharging fresh blood stool, jaundice, dysuria, edema, leukorrhagia, pudendal pruritus, scabies, leprosy, skin pruritus, the cards such as noxious dampness skin infection.
Chinese medicine provided by the invention has heat clearing and damp drying, the parasite killing dysentery relieving, protect the liver, the effect of cooling blood for hemostasis, heat-clearing and toxic substances removing, the scalable body's immunity, by suppressing the maturation of unsporulated oocysts, kill Sporulated Oocysts, improve especially T lymphocyte quantity of peripheral blood lymphocyte, improve quantity and the activity of T, bone-marrow-derived lymphocyte in immune organ, reach the purpose of anticoccidial, it is adapted to prevent the mixed infection of chicken coccidiosis and coccidiosis and antibacterial, treating both the principal and secondary aspects of a disease is the sick preparation of a kind of comparatively ideal prevention Eimeria Tenella.
Above-mentioned Chinese medicine immune formulation provided by the invention is used as feed additive.
The present invention also provides the preparation method of above-mentioned Chinese medicine immune formulation, is specially:
The first step, each crude drug component in described Chinese medicine immune formulation is mixed in proportion, obtain mixture, add the water with respect to 2 ~ 4 times of mixture qualities, decoct and process 1～3 hour, decoction liquor is filtered to concentration, obtain mastic, the relative density of described mastic is 1.15 ~ 1.18 (65 ℃);
Second step, the ethanol that is 65% ~ 75% by the determining alcohol that adds in the mastic of acquisition with respect to 3～5 times of first step mixture qualities, stirred 20 minutes ~ 40 minutes, 0～4 ℃ of lower cold preservation 1 ~ 2 hour, filter, decompression recycling ethanol, obtain and get dry extract, be ground into 100 orders ~ 200 purpose powder, obtain the Chinese medicine immune formulation.
It is a kind of for preventing the feedstuff of Eimeria Tenella disease that the present invention also provides, and its raw material comprises: Semen Tritici aestivi, bean cake, bone meal, rapeseed meal, dalcium biphosphate, vitamin E, vitamin K, pantothenic acid, lysine, methionine, threonine and for preventing the Chinese medicine immune formulation of Eimeria Tenella disease.
In described feedstuff, each constituent content can be 9kg ~ 11kg Semen Tritici aestivi, 2kg ~ 3kg bean cake, the bone meal of 500g ~ 600g, 1kg ~ 2kg rapeseed meal, the dalcium biphosphate of 300g ~ 400g, the methionine of the pantothenic acid of the vitamin E of 100g ~ 200g, the vitamin K of 100g ~ 200g, 150g ~ 250g, the lysine of 100g ~ 200g, 100g ~ 200g, the threonine of 100g ~ 200g and the Chinese medicine immune formulation of 1kg ~ 2kg.
Further, in described feedstuff, each constituent content can be the 10kg Semen Tritici aestivi, 2.5kg bean cake, the bone meal of 550g, 1.5kg rapeseed meal, the dalcium biphosphate of 350g, the methionine of the pantothenic acid of the vitamin E of 150g, the vitamin K of 150g, 200g, the lysine of 150g, 150g, the threonine of 150g and the Chinese medicine immune formulation of 1.5kg.
The present invention also provides the preparation method of above-mentioned feedstuff, and it comprises:
The first step, each crude drug component in described Chinese medicine immune formulation is mixed in proportion, obtain mixture, add the water with respect to 2 ~ 4 times of mixture qualities, decoct and process 1～3 hour, decoction liquor is filtered to concentration, obtain mastic, the relative density of described mastic is 1.15 ~ 1.18 (65 ℃);
Second step, the ethanol that is 65% ~ 75% by the determining alcohol that adds in the mastic of acquisition with respect to 3～5 times of first step mixture qualities, stirred 20 minutes ~ 40 minutes, 0～4 ℃ of lower cold preservation 1 ~ 2 hour, filter, decompression recycling ethanol, obtain and get dry extract, be ground into 100 orders ~ 200 purpose powder, obtain the Chinese medicine immune formulation;
The 3rd step, the Chinese medicine immune formulation that Semen Tritici aestivi, bean cake, bone meal, rapeseed meal, dalcium biphosphate, vitamin E, vitamin K, pantothenic acid, lysine, methionine, threonine and second step are obtained mixes, pour in spraying machine, in spraying machine, water temperature is modulated at 60 ~ 70 ℃, open aerosol apparatus, stir 1 ~ 2 minute, continue to be warming up to 90 ℃ and complete expanded;
The 4th step, add the water with respect to 0.1 ~ 0.3 times of its quality by the product after expanded, puts into granulator and granulate, and the granulator electric current is 175A;
The 5th step, dry after granulating, baking temperature is 105 ℃, drying time 15 ~ 25min; Then cooling, the cooling blower electric current is 31A, and packing, obtain described feedstuff.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how the application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
Embodiment 1 Chinese medicine immune formulation 1
By Caulis Spatholobi 40g, Herba Artemisiae Annuae 30g, Radix Rubiae 35g, Herba Euphorbiae Humifusae 25g, Flos Lonicerae 70g, Fructus Kochiae 45g, Bulbus Allii 40g, Fructus Bruceae 40g, Radix Pulsatillae 45g, Fructus Jujubae 35g, Rhizoma Imperatae 30g, Folium Lantanae Camarae 30g, Herba Taxilli 40g, Caulis Sargentodoxae 35g, Radix Urenae Lobatae 30g, Ramulus Persicae 30g, Herba Hyperici 45g, Radix Gentianae Macrophyllae 30g, Radix Stemonae 35g, Semen Pharbitidis 30g, Cortex Ailanthi 35g, Folium Viticis Negundo 30g, Radix Scutellariae 50g and Radix Sophorae Flavescentis 40g mix, obtain mixture, the water that adds 2.7kg, decoct and process 3 hours, decoction liquor is filtered, concentration, obtain mastic, described mastic is 1.18 the relative density of 65 ℃, the ethanol that is 75% by the determining alcohol that adds 3.5kg in the mastic of acquisition, stirred 40 minutes, 0 ℃ of lower cold preservation 2 hours, filter, decompression recycling ethanol, obtain and get dry extract, be ground into 200 purpose powder, obtain Chinese medicine immune formulation 1.
Embodiment 2 Chinese medicine immune formulations 2
By Caulis Spatholobi 35g, Herba Artemisiae Annuae 25g, Radix Rubiae 30g, Herba Euphorbiae Humifusae 20g, Flos Lonicerae 65g, Fructus Kochiae 40g, Bulbus Allii 35g, Fructus Bruceae 35g, Radix Pulsatillae 45g, Fructus Jujubae 35g, Rhizoma Imperatae 30g, Folium Lantanae Camarae 30g, Herba Taxilli 40g, Caulis Sargentodoxae 35g, Radix Urenae Lobatae 30g, Ramulus Persicae 30g, Herba Hyperici 45g, Radix Gentianae Macrophyllae 30g, Radix Stemonae 35g, Semen Pharbitidis 30g, Cortex Ailanthi 35g, Folium Viticis Negundo 30g, Radix Scutellariae 50g and Radix Sophorae Flavescentis 40g mix, obtain mixture, the water that adds 2.7kg, decoct and process 3 hours, decoction liquor is filtered, concentration, obtain mastic, described mastic is 1.18 the relative density of 65 ℃, the ethanol that is 75% by the determining alcohol that adds 3.5kg in the mastic of acquisition, stirred 40 minutes, 0 ℃ of lower cold preservation 2 hours, filter, decompression recycling ethanol, obtain and get dry extract, be ground into 200 purpose powder, obtain Chinese medicine immune formulation 2.
Embodiment 3 Chinese medicine immune formulations 3
By Caulis Spatholobi 40g, Herba Artemisiae Annuae 30g, Radix Rubiae 35g, Herba Euphorbiae Humifusae 25g, Flos Lonicerae 70g, Fructus Kochiae 45g, Bulbus Allii 40g, Fructus Bruceae 40g, Radix Pulsatillae 50g, Fructus Jujubae 40g, Rhizoma Imperatae 35g, Folium Lantanae Camarae 35g, Herba Taxilli 45g, Caulis Sargentodoxae 40g, Radix Urenae Lobatae 35g, Ramulus Persicae 35g, Herba Hyperici 50g, Radix Gentianae Macrophyllae 35g, Radix Stemonae 40g, Semen Pharbitidis 35g, Cortex Ailanthi 40g, Folium Viticis Negundo 35g, Radix Scutellariae 55g and Radix Sophorae Flavescentis 45g mix, obtain mixture, the water that adds 2.7kg, decoct and process 3 hours, decoction liquor is filtered, concentration, obtain mastic, described mastic is 1.18 the relative density of 65 ℃, the ethanol that is 75% by the determining alcohol that adds 3.5kg in the mastic of acquisition, stirred 40 minutes, 0 ℃ of lower cold preservation 2 hours, filter, decompression recycling ethanol, obtain and get dry extract, be ground into 200 purpose powder, obtain Chinese medicine immune formulation 3.
Embodiment 4 feedstuffs
By the 10kg Semen Tritici aestivi, 2.5kg bean cake, the bone meal of 550g, 1.5kg rapeseed meal, the dalcium biphosphate of 350g, the Chinese medicine immune formulation of embodiment 1 preparation of the methionine of the pantothenic acid of the vitamin E of 150g, the vitamin K of 150g, 200g, the lysine of 150g, 150g, the threonine of 150g and 1.5kg mixes, pour in spraying machine, in spraying machine, water temperature is modulated at 60 ~ 70 ℃, opens aerosol apparatus, stir 1 ~ 2 minute, continue to be warming up to 90 ℃ and complete expanded; Product after expanded is added to the water with respect to 0.2 times of its quality, put into granulator and granulate, the granulator electric current is 175A, and dry after granulating, baking temperature is 105 ℃, drying time 25min; Then cooling, the cooling blower electric current is 31A, and packing, obtain described feedstuff.
Embodiment 5 prophylactic trias
Coccidian oocyst
The Eimeria maxima egg capsule is provided by the veterinary of Xibei Univ. of Agricultural & Forest Science & Technology parasite laboratory.Artificial challenge's non-ball worm chicken subculture 1 time before test, obtain the test egg capsule, 29 ℃ be cultured to Sporulated after, 4 ℃ of Refrigerator stores are standby.
The feeding feedstuff
The feedstuff of the feeding embodiment of the present invention 4 preparations
The grouping of experimental animal and processing
1 age in days Luo Man egg is with public young, plant chicken house purchased from Shandong Agricultural University, just having gone out shell puts into special-purpose chicken box and transports back, in strict sterilization non-ball worm chicken coop, with non-ball worm feedstuff and drinking-water, raise, the common wheat feedstuff of feeding, wherein do not add any medicine, and the mode of adopt free choice feeding, freely drinking water is raised.During 11 age in days, choose weight close, and confirm as 120 of healthy chickling through observation, be divided at random 3 groups, 40 every group, the negative matched group of I group, the positive matched group of II group, the III group is Chinese medicine immune formulation group, the feedstuff of the feeding embodiment of the present invention 4 preparations.Divide into groups to start the same day negative control group is gavaged to normal saline (each 0. 5 mL/, 2 times/d), feeding common wheat feedstuff, do not add Chinese medicine immune formulation prepared by the embodiment of the present invention 4; The positive controls free choice feeding, drinking-water, feeding common wheat feedstuff, do not add Chinese medicine immune formulation prepared by the embodiment of the present invention 4, and the feedstuff of the Chinese medicine immune formulation group feeding embodiment of the present invention 4 preparations is until catch and kill.During 14 age in days, to II and III group Chickens Infected Sporulated Oocysts of E. maxima 1. 0 * 10
5individual/as only, after infecting, within the 8th day, to slaughter the total Test chicken.And infecting the coccidiosis same day and infecting and weigh on an empty stomach in latter the 8th day.
Clinicing symptom observation
After the inoculation coccidiosis, incidence, the clinical symptoms of chicken respectively organized in observation every day and record.After infecting, check feces the 4th, 5,6,7 day every day, records the hemafecia situation, carries out the egg capsule counting, and dead chicken is cutd open to inspection in time, finds out the cause of death.
Chinese Herbs deliberated index and standard
Survival rate: survival rate (%)=survival chicken number/(test chicken sum-Yin Fei coccidium infection factor and die unexpectedly chicken number) * 100 %.
The relative weight gain rate: the relative weight gain rate (%)=administration group or infect the rate of body weight gain of the rate of body weight gain of not administration group/infect not administration group * 100 %.
Lesion score and pathological changes value
According to the order of severity of cuing open inspection rear intestinal pathological changes, score.0 minute: without the naked eyes pathological changes; 1 minute: intestinal wall had and seldom is dispersed in petechial hemorrhage, and intestinal wall does not thicken, and content is normal; 2 minutes: intestinal contents was with a small amount of blood, and intestinal wall thickens, visible most [Dans; 3 minutes: enteral had volume blood or intestinal core (the caseous Fructus Musae block of blood clot or canescence), and plump the reaching of intestinal wall significantly is out of shape and atrophy; 4 minutes: the remarkable atrophy of intestinal, intestinal wall is extremely plump, and enteral contains blood clot or intestinal core, and when judgement, the pathological changes of both sides caecum is inconsistent sometimes, the judgement that is as the criterion of a side that should be heavy with pathological changes.
Pathological changes value=every group of average lesion score * 10.
The egg capsule value
According to gram feces egg capsule value (Oocyst s per gram feces, OPG) method, converted.
When the OPG value is 0. 00～0. 10, the egg capsule value is 0; When the OPG value is 0. 11～1. 00, the egg capsule value is 1; When the OPG value is 1. 10～1. 90, the egg capsule value is 10; When the OPG value is 2. 00～5. 90, the egg capsule value is 20; When the OPG value is 6. 00～10. 90, the egg capsule value is 30; When OPG value >=11. 0, the egg capsule value is 40.
Anticoccidial index (Anticoccidial Index, ACI)
Criterion calculation anticoccidial index with Merck company.Anticoccidial index (ACI)=(the relative weight gain rate+survival rate)-(pathological changes value+egg capsule value+hemafecia is scored).
Drug effect criterion is: when ACI is less than 120, be judged to be weak curative effect; When ACI is 120～160, be judged to be curative effect medium; When ACI is 160～180, be judged to be curative effect good; When ACI is greater than 180, be judged to be curative effect outstanding.
Feces is scored
Observe the inoculation feces of latter the 4th, 5,6 days, score with reference to the method for Morehouse, the 4th day after the artificial challenge starts to observe the blood stool situation, the most serious once the scoring by hemafecia, and calculate full cell mean.The normal note of feces 0 minute; Every chicken hemafecia on average occurred how much piling and just remembered how many minutes respectively this day.
Pathology change
Attack after worm the 8th day, cut open and kill the total Test chicken, it is cutd open to inspection, get respectively observation and lesion score that duodenum, small intestinal leading portion, small intestinal back segment, caecum carry out pathological change.
Histopathology is observed
The making of histopathologic slide (H. E dyeing) flow process: draw materials 2 fix 2 flushing 2 gradient alcohol dehydration (70 % ethanol-80 % ethanol-90 % ethanol-95 % ethanol-100 % ethanol I-100 % ethanol II)-dimethylbenzene transparent-waxdip-embedding-paster-dyeing (dewaxing-transfect cell core-transfect cell matter-dehydration)-sealing.Observing and record histopathology under light microscopic changes.
Result
Clinical symptoms
The inoculation coccidiosis after the 4th day, except negative control group, other group chickens all show clinical symptoms in various degree, and as poor as mental status, depressed, drowsiness, feed intake reduces, feather is fluffy and disorderly, both wings are sagging, drop-head necking down, the lethargy of closing one's eyes, slow-witted vertical, the row's bloody stool etc. of being reluctant to walk about, peeling off.At postvaccinal the 5th, 6 days, the positive controls chicken was discharged a large amount of hemafecias, and Chinese medicine immune formulation group hemafecia is scored all lower than positive controls.
Pathological observation
Observe the pathological change result visible, any pathological changes does not appear in negative control group, and the positive controls pathological changes is the most serious, and Chinese medicine immune formulation group has pathological changes to occur.
Each histopathology of whole body histology situation of change is as follows:
Small intestinal: positive controls lamina propria telangiectasis hyperemia; Chinese medicine immune formulation group lamina propria, Submucosa capillary injection, expansion disappear.
Fabricius bursa: positive controls fabricius bursa lamina propria lymphocyte nuclear is concentrated, cracked; Chinese medicine immune formulation group fabricius bursa lamina propria lymphocyte nuclear concentration phenomena disappears.
Lungs: the telangiectasis of positive controls alveolar wall is full of erythrocyte; Interstitial vasodilation.The telangiectasis of Chinese medicine immune formulation group alveolar wall disappears.
Liver: positive controls central vein, the expansion of sinus hepaticus gap are full of erythrocyte; Swelling of liver cell, muddiness.Chinese medicine immune formulation group central vein, the expansion of sinus hepaticus gap disappear.
Heart: positive controls cardiac muscle fiber swelling has a large amount of subparticles in endochylema; Chinese medicine immune formulation group pathological changes is not obvious.
Brain: positive controls interstitial venule vasodilation hyperemia; The Chinese herb on the prevention group is without congested, bleeding, without significant change.
Kidney: the swelling of positive controls renal cells, a large amount of fine graineds, appear in the endochylema muddiness in endochylema.The visible urinary cast of part renal tubules tube chamber, interstitial vasodilation, hyperemia, hemorrhage.Chinese medicine immune formulation group is without significant change.
Chinese medicine immune formulation group ACI has improved 101. 8 % than positive controls; Survival rate reaches 90 %; The relative weight gain rate is 84. 94 %, proves that it has good anticoccidial effect.
The results are shown in Table 1.
Table 1 Chinese medicine immune formulation anticoccidial effect
Annotate: it is fine that ACI is greater than 180 expression anticoccidial effects, is greater than 160 expression anticoccidial effects better, is less than 160 expressions without the anticoccidial effect.
All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (9)
1. one kind for preventing the feedstuff of Eimeria Tenella disease, it is characterized in that: raw material comprises Semen Tritici aestivi, bean cake, bone meal, rapeseed meal, dalcium biphosphate, vitamin E, vitamin K, pantothenic acid, lysine, methionine, threonine and above-mentioned for preventing the Chinese medicine immune formulation of Eimeria Tenella disease.
2. feedstuff as claimed in claim 1, it is characterized in that: each raw material components can be 9kg ~ 11kg Semen Tritici aestivi, 2kg ~ 3kg bean cake, the bone meal of 500g ~ 600g, 1kg ~ 2kg rapeseed meal, the dalcium biphosphate of 300g ~ 400g, the methionine of the pantothenic acid of the vitamin E of 100g ~ 200g, the vitamin K of 100g ~ 200g, 150g ~ 250g, the lysine of 100g ~ 200g, 100g ~ 200g, the threonine of 100g ~ 200g and the Chinese medicine immune formulation of 1kg ~ 2kg.
3. feedstuff as claimed in claim 1 or 2, it is characterized in that: the crude drug of described Chinese medicine immune formulation comprises Caulis Spatholobi, Herba Artemisiae Annuae, Radix Rubiae, Herba Euphorbiae Humifusae, Flos Lonicerae, the Fructus Kochiae, Bulbus Allii, Fructus Bruceae, the Radix Pulsatillae, Fructus Jujubae, Rhizoma Imperatae, Folium Lantanae Camarae, Herba Taxilli, Caulis Sargentodoxae, Radix Urenae Lobatae, Ramulus Persicae, Herba Hyperici, Radix Gentianae Macrophyllae, the Radix Stemonae, Semen Pharbitidis, Cortex Ailanthi, Folium Viticis Negundo, Radix Scutellariae and Radix Sophorae Flavescentis.
4. feedstuff as described as claims 1 to 3, it is characterized in that: the weight of each crude drug of described Chinese medicine immune formulation is respectively Caulis Spatholobi 35g～45g, Herba Artemisiae Annuae 25g～35g, Radix Rubiae 30g～40g, Herba Euphorbiae Humifusae 20g～30g, Flos Lonicerae 65g～75g, Fructus Kochiae 40g～50g, Bulbus Allii 35g～45g, Fructus Bruceae 35g～45g, Radix Pulsatillae 40g～50g, Fructus Jujubae 30g～40g, Rhizoma Imperatae 25g～35g, Folium Lantanae Camarae 25g～35g, Herba Taxilli 35g～45g, Caulis Sargentodoxae 30g～40g, Radix Urenae Lobatae 25g～35g, Ramulus Persicae 25g～35g, Herba Hyperici 40g～50g, Radix Gentianae Macrophyllae 25g～35g, Radix Stemonae 30g～40g, Semen Pharbitidis 25g～35g, Cortex Ailanthi 30g～40g, Folium Viticis Negundo 25g～35g, Radix Scutellariae 45g～55g and Radix Sophorae Flavescentis 35g～45g.
5. the preparation method of the described feedstuff of claim 1 to 4, is characterized in that, comprising:
The first step, each crude drug component in described Chinese medicine immune formulation is mixed in proportion, obtain mixture, add the water with respect to 2 ~ 4 times of mixture qualities, decoct and process 1～3 hour, decoction liquor is filtered to concentration, obtain mastic, the relative density of described mastic is 1.15 ~ 1.18 (65 ℃);
Second step, the ethanol that is 65% ~ 75% by the determining alcohol that adds in the mastic of acquisition with respect to 3～5 times of first step mixture qualities, stirred 20 minutes ~ 40 minutes, 0～4 ℃ of lower cold preservation 1 ~ 2 hour, filter, decompression recycling ethanol, obtain and get dry extract, be ground into 100 orders ~ 200 purpose powder, obtain the Chinese medicine immune formulation;
The 3rd step, the Chinese medicine immune formulation that Semen Tritici aestivi, bean cake, bone meal, rapeseed meal, dalcium biphosphate, vitamin E, vitamin K, pantothenic acid, lysine, methionine, threonine and second step are obtained mixes, pour in spraying machine, in spraying machine, water temperature is modulated at 60 ~ 70 ℃, open aerosol apparatus, stir 1 ~ 2 minute, continue to be warming up to 90 ℃ and complete expanded;
The 4th step, add the water with respect to 0.1 ~ 0.3 times of its quality by the product after expanded, puts into granulator and granulate, and the granulator electric current is 175A;
The 5th step, dry after granulating, baking temperature is 105 ℃, drying time 15 ~ 25min; Then cooling, the cooling blower electric current is 31A, and packing, obtain described feedstuff.
6. one kind for preventing the Chinese medicine immune formulation of Eimeria Tenella disease, and it is characterized in that: crude drug comprises Caulis Spatholobi, Herba Artemisiae Annuae, Radix Rubiae, Herba Euphorbiae Humifusae, Flos Lonicerae, the Fructus Kochiae, Bulbus Allii, Fructus Bruceae, the Radix Pulsatillae, Fructus Jujubae, Rhizoma Imperatae, Folium Lantanae Camarae, Herba Taxilli, Caulis Sargentodoxae, Radix Urenae Lobatae, Ramulus Persicae, Herba Hyperici, Radix Gentianae Macrophyllae, the Radix Stemonae, Semen Pharbitidis, Cortex Ailanthi, Folium Viticis Negundo, Radix Scutellariae and Radix Sophorae Flavescentis.
7. Chinese medicine immune formulation as claimed in claim 6, it is characterized in that: the weight of each crude drug is respectively:
Caulis Spatholobi 35g～45g, Herba Artemisiae Annuae 25g～35g, Radix Rubiae 30g～40g, Herba Euphorbiae Humifusae 20g～30g, Flos Lonicerae 65g～75g, Fructus Kochiae 40g～50g, Bulbus Allii 35g～45g, Fructus Bruceae 35g～45g, Radix Pulsatillae 40g～50g, Fructus Jujubae 30g～40g, Rhizoma Imperatae 25g～35g, Folium Lantanae Camarae 25g～35g, Herba Taxilli 35g～45g, Caulis Sargentodoxae 30g～40g, Radix Urenae Lobatae 25g～35g, Ramulus Persicae 25g～35g, Herba Hyperici 40g～50g, Radix Gentianae Macrophyllae 25g～35g, Radix Stemonae 30g～40g, Semen Pharbitidis 25g～35g, Cortex Ailanthi 30g～40g, Folium Viticis Negundo 25g～35g, Radix Scutellariae 45g～55g and Radix Sophorae Flavescentis 35g～45g.
8. Chinese medicine immune formulation as described as claim 6 or 7, it is characterized in that: the weight of each crude drug is respectively:
Caulis Spatholobi 35g～40g, Herba Artemisiae Annuae 25g～30g, Radix Rubiae 30g～35g, Herba Euphorbiae Humifusae 20g～25g, Flos Lonicerae 65g～70g, Fructus Kochiae 40g～45g, Bulbus Allii 35g～40g, Fructus Bruceae 35g～40g, Radix Pulsatillae 45g～50g, Fructus Jujubae 35g～40g, Rhizoma Imperatae 30g～35g, Folium Lantanae Camarae 30g～35g, Herba Taxilli 40g～45g, Caulis Sargentodoxae 35g～40g, Radix Urenae Lobatae 30g～35g, Ramulus Persicae 30g～35g, Herba Hyperici 45g～50g, Radix Gentianae Macrophyllae 30g～35g, Radix Stemonae 35g～40g, Semen Pharbitidis 30g～35g, Cortex Ailanthi 35g～40g, Folium Viticis Negundo 30g～35g, Radix Scutellariae 50g～55g and Radix Sophorae Flavescentis 40g～45g.
9. the preparation method of the described Chinese medicine immune formulation of claim 6 to 8 is characterized in that:
The first step, each crude drug component in described Chinese medicine immune formulation is mixed in proportion, obtain mixture, add the water with respect to 2 ~ 4 times of mixture qualities, decoct and process 1～3 hour, decoction liquor is filtered to concentration, obtain mastic, the relative density of described mastic is 1.15 ~ 1.18 (65 ℃);
Second step, the ethanol that is 65% ~ 75% by the determining alcohol that adds in the mastic of acquisition with respect to 3～5 times of first step mixture qualities, stirred 20 minutes ~ 40 minutes, 0～4 ℃ of lower cold preservation 1 ~ 2 hour, filter, decompression recycling ethanol, obtain and get dry extract, be ground into 100 orders ~ 200 purpose powder, obtain the Chinese medicine immune formulation.
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| CN106615890A (en) * | 2016-10-31 | 2017-05-10 | 南宁市美嘉农饲料有限责任公司 | Daily ration for young ostriches |
| CN106578375A (en) * | 2016-11-29 | 2017-04-26 | 南宁学院 | Feed additive for preventing coccidiosis of gooses |
| CN112006187A (en) * | 2020-10-14 | 2020-12-01 | 甘肃农业大学 | Anti-coccidiosis feed additive for large-scale ecological chicken raising and preparation and use methods thereof |
| CN112891363A (en) * | 2021-03-23 | 2021-06-04 | 广东省农业科学院动物卫生研究所 | New use of New Zealand Vitexin 2 and New Zealand Vitexin 3 |
| CN112891363B (en) * | 2021-03-23 | 2023-08-15 | 广东省农业科学院动物卫生研究所 | New Zealand vitexin 2 and new Zealand vitexin 3 application |
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