CN1895342A - Fowl anticoccidial medicinal composition and its preparation - Google Patents
Fowl anticoccidial medicinal composition and its preparation Download PDFInfo
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- CN1895342A CN1895342A CN 200610014332 CN200610014332A CN1895342A CN 1895342 A CN1895342 A CN 1895342A CN 200610014332 CN200610014332 CN 200610014332 CN 200610014332 A CN200610014332 A CN 200610014332A CN 1895342 A CN1895342 A CN 1895342A
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Abstract
A composite anticoccidial medicine for fowls is prepared from antifebrile dichroa root, bupleurum root, flavescent sophora root and sweet wormwood through cutting short, immersing in water, decocting three times while filtering, depositing in alcohol, filtering and sterilizing.
Description
Technical field
The present invention relates to stud bird medication thing and preparation method thereof, especially for the medicine and the manufacture method thereof of treatment avian coccidiosis.
Background technology
Chicken coccidiosis is a kind of modal disease.Cause of disease is a kind of unicellular protozoon, parasitizes in the intestinal mucosa epithelial cell, is one of serious disease of harm poultry husbandry.The easy repeated infection of chicken coccidiosis be difficult for to be eliminated, and coccidiosis causes that easily body growth is slow, and easily dead chicken is quickened, increased to his disease of secondary.Parasitize coccidiosis in the epithelial cell by in parasitic intestinal submucosa tissue, drawing the nutrient growth and breeding, cause disease chicken anemia, become thin, poor growth and death.The Excreta that coccidiosis produces in metabolic process is to the toxic effect of chicken.Coccidiosis is at the intestinal submucosa tissue endoparasitism of chicken, intestinal submucosa tissue is damaged and is vulnerable to the invasion and attack of pathogenic bacterium in the intestinal and the secondary bacterial enteritis quickens the disease chicken death and increases mortality rate.
In the industry of raising chickens, coccidiosis is the bigger a kind of disease of hazardness, and its economic loss that causes is difficult to estimate.Up to the present, though people constantly develop the medicine that the control coccidiosis is had better effects, but mainly based on sulfa drugs, drug residue is big, has a strong impact on the outlet of broiler, in recent years, the coccidiosis attenuated vaccine has appearred again, but from thorough control or to control the pathogenetic target of coccidiosis preferably still far apart, therefore, develop a kind of based on Chinese medicine, drug residue free, curative effect certain the pharmaceutical composition of treatment avian coccidiosis significant.
Summary of the invention
The objective of the invention is to by providing a stud bird with Anticoccidiosis pharmaceutical composition and preparation method thereof, and then overcome the problem that exists in the above-mentioned background technology.
The technology used in the present invention solution is that described fowl is a kind of brown liquid that contains Chinese herbal medicine Radix Dichroae, Radix Bupleuri, Radix Sophorae Flavescentis and Herba Artemisiae Annuae effective ingredient with Anticoccidiosis pharmaceutical composition.
Described fowl carries out according to following steps successively with the preparation of Anticoccidiosis pharmaceutical composition:
(1) getting Chinese crude drug Radix Dichroae 7-23 part, Radix Bupleuri 2-18 part, Radix Sophorae Flavescentis 5-27 part and Herba Artemisiae Annuae 3-12 part by weight respectively cleans also dry; The preferred parts by weight of described Chinese crude drug are 18 parts of Radix Dichroaes, 12 parts of Radix Bupleuri, 23 parts of Radix Sophorae Flavescentiss, 9 parts of Herba Artemisiae Annuaes;
Selecting for use of described Chinese crude drug should meet the relevant regulations of " Chinese veterinary drug allusion quotation ".
(2) described Chinese crude drug is cut into thin segment.Length is controlled at 3-20 centimetre
(3) with above-mentioned each composition gross weight 4-9 clear water doubly above-mentioned Chinese crude drug was soaked 1--24 hour, be heated to 50-100 ℃, successively decoct 3 times, each 1--3 hour.Preferred conditional is the medical material that will cut with the clear water soak at room temperature of 5 times of its gross weights 2 hours, and reheat to 90 is spent, and successively decocts each 2 hours 2 times.
(4) successively leach medicinal liquid, discard medicinal residues, precipitation, remove impurity filters, sterilization, promptly.
Described remove impurity process is used conventional decoction and alcohol sedimentation technique remove impurity.
During use, according to 0.2-1ml/d only, the dosage drinking-water or the drip that are preferably 0.5ml/d get final product.
The chicken of artificial challenge's coccidiosis is adopted product treatment of the present invention, avian coccidium infection is had higher curative effect, symptom obviously alleviates and gradually recovery after the medication, and body weight increases, and its curative effect is suitable with the sulfaclozine soluble powder of sodium.
Product of the present invention is a pure Chinese medicinal preparation, and the medical material of respectively distinguishing the flavor of in the side is " genuine medicinal materials " purity height, strong drug action, has effectively improved stability of drug, and medicine density height, does not stop up nipple drinking device; Dosage reduces, but has the function of the good worm of killing.
In manufacturing process, select traditional decocting method to extract according to character of medicinal material, the final finished stability of making is high, content has measurability, has solved the shortcoming of Chinese medicine difficult quality monitoring, and significantly reduces and avoid storage process to take place to decompose and sedimentary probability.
Formula for a product of the present invention is reasonable, honor is brought into play the function of its parasite killing, damp eliminating from the principles of formulating prescriptions of the traditional Chinese medical science " monarch, minister, help, make ", and regulates the property of medicine, given full play to the theory of Chinese medicine " organic conception " and " dialectical executing controlled ", treating both the principal and secondary aspects of a disease can strengthen the repair of intestinal mucosa simultaneously, and the immunity of enhancing body and premunition, play the obvious treatment effect, prevention at ordinary times can make disease incidence rate obviously reduce, and alleviates disease symptom greatly, effectively reduces mortality rate.
The specific embodiment
Below in conjunction with embodiment, details are as follows to the present invention:
Embodiment 1
Carry out as follows:
Get Radix Dichroae 7 grams, Radix Bupleuri 18 grams, Radix Sophorae Flavescentis 27 grams, Herba Artemisiae Annuae 3 grams; With described Radix Dichroae, Radix Bupleuri, Radix Sophorae Flavescentis, Herba Artemisiae Annuae is cut into thin segment, and length is controlled at 15 centimetres, soaks 3 hours with the clear water of above-mentioned each composition gross weight 275ml, is heated to 100 ℃, successively decocts each 1 hour 3 times.Leach medicinal liquid, discard medicinal residues, precipitation is used the decoction and alcohol sedimentation technique remove impurity, filter, and sterilization, promptly.
Embodiment 2
Carry out as follows:
Get Radix Dichroae 23 grams, Radix Bupleuri 2 grams, Radix Sophorae Flavescentis 5 grams, Herba Artemisiae Annuae 12 grams; With described Radix Dichroae, Radix Bupleuri, Radix Sophorae Flavescentis, Herba Artemisiae Annuae is cut into thin segment, and length is controlled at 8 centimetres, uses the clear water of 329ml to soak 1 hour, is heated to 100 ℃, successively decocts each 2 hours 3 times.Leach medicinal liquid, discard medicinal residues, precipitation is used the decoction and alcohol sedimentation technique remove impurity, filter, and sterilization, promptly.
Embodiment 3
Carry out as follows:
Get Radix Dichroae 15 grams, Radix Bupleuri 12 grams, Radix Sophorae Flavescentis 23 grams, Herba Artemisiae Annuae 9 grams; With described Radix Dichroae, Radix Bupleuri, Radix Sophorae Flavescentis, Herba Artemisiae Annuae is cut into thin segment, and length is controlled at 3 centimetres, soaks 3 hours with the 250ml clear water, is heated to 100 ℃, successively decocts each 1.5 hours 3 times.Leach medicinal liquid, discard medicinal residues, precipitation is used the decoction and alcohol sedimentation technique remove impurity, filter, and sterilization, promptly.
Embodiment 4
Carry out as follows:
Get Radix Dichroae 18 grams, Radix Bupleuri 12 grams, Radix Sophorae Flavescentis 27 grams, Herba Artemisiae Annuae 9 grams; With described Radix Dichroae, Radix Bupleuri, Radix Sophorae Flavescentis, Herba Artemisiae Annuae is cut into thin segment, and length is controlled at 10 centimetres, soaks 5 hours with the 330ml clear water, is heated to 100 ℃, successively decocts each 2 hours 3 times.Leach medicinal liquid, discard medicinal residues, precipitation is used the decoction and alcohol sedimentation technique remove impurity, filter, and sterilization, promptly.
Embodiment 5
Carry out as follows:
Get Radix Dichroae 20 grams, Radix Bupleuri 15 grams, Radix Sophorae Flavescentis 17 grams, Herba Artemisiae Annuae 5 grams; With described Radix Dichroae, Radix Bupleuri, Radix Sophorae Flavescentis, Herba Artemisiae Annuae is cut into thin segment, and length is controlled at 5 centimetres, soaks 12 hours with the 228ml clear water, is heated to 100 ℃, successively decocts each 2 hours 3 times.Leach medicinal liquid, discard medicinal residues, precipitation is used the decoction and alcohol sedimentation technique remove impurity, filter, and sterilization, promptly
Embodiment 6
Carry out as follows:
Get Radix Dichroae 19 grams, Radix Bupleuri 13 grams, Radix Sophorae Flavescentis 12 grams, Herba Artemisiae Annuae 10 grams; With described Radix Dichroae, Radix Bupleuri, Radix Sophorae Flavescentis, Herba Artemisiae Annuae is cut into thin segment, and length is controlled at 4 centimetres, soaks 10 hours with the 270ml clear water, is heated to 100 ℃, each 2 hours, successively decocts 3 times.Leach medicinal liquid, discard medicinal residues, precipitation is used the decoction and alcohol sedimentation technique remove impurity, filter, and sterilization, promptly
Embodiment 7
Carry out as follows:
Get Radix Dichroae 12 grams, Radix Bupleuri 10 grams, Radix Sophorae Flavescentis 15 grams, Herba Artemisiae Annuae 9 grams; With described Radix Dichroae, Radix Bupleuri, Radix Sophorae Flavescentis, Herba Artemisiae Annuae is cut into thin segment, and length is controlled at 6 centimetres, soaks 7 hours with the 230ml clear water, is heated to 100 ℃, each 3 hours, successively decocts 3 times.Leach medicinal liquid, discard medicinal residues, precipitation is used the decoction and alcohol sedimentation technique remove impurity, filter, and sterilization, promptly
Embodiment 8
Carry out as follows:
Get Radix Dichroae 7 grams, Radix Bupleuri 2 grams, Radix Sophorae Flavescentis 5 grams, Herba Artemisiae Annuae gram; With described Radix Dichroae, Radix Bupleuri, Radix Sophorae Flavescentis, Herba Artemisiae Annuae is cut into thin segment, and length is controlled at 6 centimetres, soaks 7 hours with the 85ml clear water, is heated to 100 ℃, each 1 hour, decocts 3 times.Leach medicinal liquid, discard medicinal residues, precipitation is used the decoction and alcohol sedimentation technique remove impurity, filter, and sterilization, promptly
Embodiment 9
Carry out as follows:
Get Radix Dichroae 23 grams, Radix Bupleuri 18 grams, Radix Sophorae Flavescentis 27 grams, Herba Artemisiae Annuae gram; With described Radix Dichroae, Radix Bupleuri, Radix Sophorae Flavescentis, Herba Artemisiae Annuae is cut into thin segment, and length is controlled at 6 centimetres, soaks 24 hours with above-mentioned each composition gross weight 720ml clear water doubly, is heated to 50 ℃, each 2 hours, decocts 3 times.Leach medicinal liquid, discard medicinal residues, precipitation is used the decoction and alcohol sedimentation technique remove impurity, filter, and sterilization, promptly
The test example:
The fast large-scale broiler chicken of AA is available from Tianjin City Livestock Raising and Veterinary Inst.'s experimental animal room, average weight 1.62kg, 30 ages in days.
Adopt artificial onset's mode, occur the symptom (negative control group except) identical in 4 days with coccidiosis.5 that choose in the positive controls are cutd open inspection and laboratory diagnosis, and its result is the coccidium infection of chicken.
Dosage by 1.0ml/d only is respectively high dose, and middle dosage is only pressed 0.5ml/d, and low dosage is pressed 0.2ml/d.After the medication, the clinical symptoms complete obiteration is searched for food, is drunk water and physical signs such as spirit recovers normal for curing fully, cures the cure rate that number accounts for this group test sum and is a hundred per cent.
Claims (6)
1. a stud bird is used Anticoccidiosis pharmaceutical composition, it is characterized in that described compositions is the brown liquid that contains Chinese crude drug Radix Dichroae, Radix Bupleuri, Radix Sophorae Flavescentis and Herba Artemisiae Annuae effective ingredient.
One kind according to claim 1 fowl it is characterized in that described preparation method carries out successively according to following steps with the preparation method of Anticoccidiosis pharmaceutical composition:
(1) getting Chinese crude drug Radix Dichroae 7-23 part, Radix Bupleuri 2-18 part, Radix Sophorae Flavescentis 5-27 part and Herba Artemisiae Annuae 3-12 part by weight respectively cleans also dry;
(2) described Chinese crude drug is cut into thin segment;
(3) with above-mentioned each composition gross weight 4-9 clear water doubly above-mentioned Chinese crude drug was soaked 1--24 hour, be heated to 50-100 ℃, successively decoct 3 times, each 1--3 hour;
(4) successively leach medicinal liquid, discard medicinal residues, precipitation, remove impurity filters, sterilization, promptly.
3. fowl according to claim 2 is characterized in that with the preparation method of Anticoccidiosis pharmaceutical composition the preferred parts by weight of Chinese crude drug are 18 parts of Radix Dichroaes, 12 parts of Radix Bupleuri, 23 parts of Radix Sophorae Flavescentiss, 9 parts of Herba Artemisiae Annuaes;
4. according to the preparation method of claim 2 or 3 described fowl usefulness Anticoccidiosis pharmaceutical compositions, it is characterized in that described Radix Dichroae, Radix Bupleuri, Radix Sophorae Flavescentis and Herba Artemisiae Annuae length are controlled at 3-20 centimetre;
5. fowl according to claim 2 is with the preparation method of Anticoccidiosis pharmaceutical composition, it is characterized in that (3) described optimum condition is the medical material that will cut with the clear water soak at room temperature of 5 times of its gross weights 2 hours, reheat decoction 3 times, each 2 hours.
6. fowl according to claim 2 is characterized in that the conventional decoction and alcohol sedimentation technique remove impurity of described remove impurity process use with the preparation method of Anticoccidiosis pharmaceutical composition.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200610014332 CN1895342A (en) | 2006-06-13 | 2006-06-13 | Fowl anticoccidial medicinal composition and its preparation |
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| CN 200610014332 CN1895342A (en) | 2006-06-13 | 2006-06-13 | Fowl anticoccidial medicinal composition and its preparation |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101579451B (en) * | 2009-07-07 | 2011-06-29 | 广东溢多利生物科技股份有限公司 | Chicken coccidia powder and preparation method thereof |
| CN103417654A (en) * | 2013-08-12 | 2013-12-04 | 河南惠通天下生物工程有限公司 | Traditional Chinese medicine composition for preventing and controlling poultry coccidiosis and preparation method of same |
| CN103495091A (en) * | 2013-10-22 | 2014-01-08 | 山东新希望六和集团有限公司 | Traditional Chinese medicine immune stimulant for preventing Eimeria tenella infections |
| CN104546871A (en) * | 2013-10-21 | 2015-04-29 | 洛阳惠中兽药有限公司 | Amprolium hydrochloride-ethopabate-sulfaquinoxaline medicine composition powder and preparation |
| CN104887784A (en) * | 2015-05-04 | 2015-09-09 | 霍邱县科瑞达禽业有限公司 | Traditional Chinese medicine for treating commercial chicken coccidiosis, and preparation method thereof |
| CN108653541A (en) * | 2017-03-31 | 2018-10-16 | 天津市佳禾蛋鸡养殖有限公司 | Treat the chicken medication of globidiosis strengthen immunity |
| CN109939138A (en) * | 2019-04-11 | 2019-06-28 | 武汉科缘生物发展有限责任公司 | A kind of Chinese herbal microecological preparation and its application of anti-Eimeria species |
| CN116036188A (en) * | 2023-02-14 | 2023-05-02 | 北京大北农动物保健科技有限责任公司 | Traditional Chinese medicine composition for preventing and treating chicken coccidiosis as well as preparation method and application thereof |
-
2006
- 2006-06-13 CN CN 200610014332 patent/CN1895342A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101579451B (en) * | 2009-07-07 | 2011-06-29 | 广东溢多利生物科技股份有限公司 | Chicken coccidia powder and preparation method thereof |
| CN103417654A (en) * | 2013-08-12 | 2013-12-04 | 河南惠通天下生物工程有限公司 | Traditional Chinese medicine composition for preventing and controlling poultry coccidiosis and preparation method of same |
| CN103417654B (en) * | 2013-08-12 | 2016-02-10 | 河南惠通天下生物工程有限公司 | A kind ofly prevent and treat Chinese medicine composition of Avian Coccidia disease and preparation method thereof |
| CN104546871A (en) * | 2013-10-21 | 2015-04-29 | 洛阳惠中兽药有限公司 | Amprolium hydrochloride-ethopabate-sulfaquinoxaline medicine composition powder and preparation |
| CN103495091A (en) * | 2013-10-22 | 2014-01-08 | 山东新希望六和集团有限公司 | Traditional Chinese medicine immune stimulant for preventing Eimeria tenella infections |
| CN103495091B (en) * | 2013-10-22 | 2015-07-01 | 山东新希望六和集团有限公司 | Traditional Chinese medicine immune stimulant for preventing Eimeria tenella infections |
| CN104887784A (en) * | 2015-05-04 | 2015-09-09 | 霍邱县科瑞达禽业有限公司 | Traditional Chinese medicine for treating commercial chicken coccidiosis, and preparation method thereof |
| CN108653541A (en) * | 2017-03-31 | 2018-10-16 | 天津市佳禾蛋鸡养殖有限公司 | Treat the chicken medication of globidiosis strengthen immunity |
| CN109939138A (en) * | 2019-04-11 | 2019-06-28 | 武汉科缘生物发展有限责任公司 | A kind of Chinese herbal microecological preparation and its application of anti-Eimeria species |
| CN116036188A (en) * | 2023-02-14 | 2023-05-02 | 北京大北农动物保健科技有限责任公司 | Traditional Chinese medicine composition for preventing and treating chicken coccidiosis as well as preparation method and application thereof |
| CN116036188B (en) * | 2023-02-14 | 2024-02-09 | 北京大北农动物保健科技有限责任公司 | Traditional Chinese medicine composition for preventing and treating chicken coccidiosis as well as preparation method and application thereof |
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Open date: 20070117 |