CN1145791A - Coccidiosis-resisting Chinese herbal veterinary medicine and its prepn - Google Patents
Coccidiosis-resisting Chinese herbal veterinary medicine and its prepn Download PDFInfo
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- CN1145791A CN1145791A CN 95112130 CN95112130A CN1145791A CN 1145791 A CN1145791 A CN 1145791A CN 95112130 CN95112130 CN 95112130 CN 95112130 A CN95112130 A CN 95112130A CN 1145791 A CN1145791 A CN 1145791A
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- coccidiosis
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Abstract
The veterinary medicine is a granule prepared with extract of several medicinal herbs including artemisia apiacea, Java brucea, Dichroa febrifuga, etc. Clinical experiment and field experiment show that the veterinary medicine has high prevention effect to various coccidiosis. It has wide prevention spectrum, protection rate up to 100% and no side effect on farm animals.
Description
The invention belongs to field of veterinary, is a kind of Chinese herbal medicine veterinary drug that active ingredient is made that extracts from Chinese herbal medicine.
Coccidiosis is the very wide parasite protozoacide of a kind of distribution, is one of principal disease that causes world's aquaculture economic loss.Domestic animal, wild beast, birds, amphibian animal etc. all have coccidiosis, and wherein chicken coccidiosis harm is especially serious, and infection rate is quite high, and mortality rate is up to more than 80%, and in case the very difficult radical cure of falling ill.The coccidiostat that uses is mainly chemical synthetic drug at present, and poison pair effect is big, and the drug residue height has drug resistance, uses inconvenience, the easy defectives such as rotten and use cost height that lost efficacy.Medicine as treatment chicken coccidiosis commonly used at present has: gram ball powder, Robenidine, furazolidone, sulfa drugs, Maduramicin, Salinomycin, Buddhist nun's carbazine etc.Wherein restrain ball powder, Robenidine, the spirit of dysentery thing, sulfa drugs, in the outlet livestock products, forbid.And the toxicity of Maduramicin, Salinomycin, Buddhist nun's carbazine is also too big, and drug resistance is arranged.
The object of the present invention is to provide a kind of nontoxic pair of effect, drug residue free, have broad spectrum activity, efficient anticoccidial veterinary drug easy to use.
Solution of the present invention is that to select for use with the Herba Artemisiae Annuae be the herbal prescription of key component, and containing the Herba Artemisiae Annuae element in the Herba Artemisiae Annuae is a kind of peroxy ketal sesquiterpene lactones compounds, is and the diverse new chemical combination of known antimalarial structure, and its molecular formula is C
15H
22O
5, molecular weight is 282.36, this chemical compound has the height killing action to type phorozoon (schizont) in the plasmodium erythrocyte.Include components such as chicken dawn, Radix Dichroae, Radix Sanguisorbae and Radix Glycyrrhizae in this prescription, its constituent content is (weight %): 40-60 Herba Artemisiae Annuae, 8-12 crow dawn, the Radix Dichroae of 6-24, the Radix Sanguisorbae of 8-12 and the Radix Glycyrrhizae of 8-12.Above-mentioned constituent is respectively with ethanol and water extraction, and effective component extracting therefrom, leaching liquid add appropriate amount of starch, sucrose, pelletize again and make a kind of anticoccidial electuary after concentrating.
Coccidiosis Chinese herbal medicine veterinary drug of the present invention, its preparation method may further comprise the steps:
A) five tastes Chinese herbal medicine such as Herba Artemisiae Annuae, crow dawn, Radix Dichroae, Radix Sanguisorbae, Radix Glycyrrhizae are mixed in proportion after, with 95% after alcohol-pickled 48 hours, leach soak;
B) solids moves in the frying pan, and water decocts twice, each 1.5 hours, leaches filtrate;
C) merging of above three parts of filtrates is put into concentration tank, under reduced pressure concentrate, pressure is 0.025Mpa, and temperature 50-60 ℃ is about 1.48 until the proportion of concentrated solution;
D) take out concentrated solution and place blending tank, add starch, sucrose and ethanol respectively, the mixing ratio of concentrated solution and starch, sucrose is 2: 1: 1.Make after mixing thoroughly diameter 1-2 millimeter granule, the oven dry after, with 50 the gram one the bag carry out packing, so just made the said coccidiosis Chinese herbal medicine veterinary drug that is used for.
During use, be mixed with 0.05% solution for fowl poultry time usefulness, perhaps mix and stir in feedstuff edible with water dissolution.
Concrete instance of reuse further specifies the present invention now.Take by weighing 5 kilograms of Herba Artemisiae Annuae, 1 kilogram of crow dawn, 2 kilograms of Radix Dichroaes behind 1 kilogram of Radix Sanguisorbae and 1 kilogram of mixing of Radix Glycyrrhizae, added 95% concentration alcohol-pickled 48 hours, and the addition of ethanol was fully soaked with above-mentioned medical material and was exceeded, and leached leachate.Filtering residue moves in the frying pan and decocts with water twice, and each amount of water exceeded to expire medical material, fried in shallow oil one and a half hours at every turn, leached filtrate.After above-mentioned three parts of filtrates merging, to put into concentration tank and carry out concentrating under reduced pressure, operating pressure is 0.025Mpa, and temperature is 55 ℃, and can reclaim the ethanol that steams this moment, till concentrated solution proportion is about 1.48.Get concentrated solution and place blending tank for 2 parts, add 1 part of soluble starch respectively.1 part of sucrose and ethanol are mixed thoroughly in right amount, make the oven dry of 1-2 millimeter granule medicament, can make 500 gram granule medicaments, so just make the Chinese herbal medicine veterinary drug of said coccidiosis, and packing is used.
For showing the prevention effect of the present invention, the clinical effectiveness test of prevention coccidiosis, the field test of prevention broiler coccidiosis and the clinical trial of prevention broiler coccidiosis have been done according to a conventional method respectively to coccidiosis.
The clinical effectiveness test of prevention coccidiosis is undertaken by Laiyang Agricultural College.Test chicken: 220 of Luo Man chickens that just go out shell are provided by the Laiyang Agricultural College animal farm, in the non-ball worm environment, brood to 14 ages in days, reject weak young sick young bird, be divided into 11 groups with 220 at random, raise in cages respectively in the sterilization after young cage in for the examination, feedstuff is purchased in Laiyang City reform through labour detachment.Do not contain coccidiostat in the feedstuff, through baking disinfecting.Drinking-water uses behind scalding; The test egg capsule, provide the purebred spore egg capsule of Eimeria tenella of preservation by the parasitic zooecium of Laiyang Agricultural College, infect results through the non-ball worm chicken and place 25 ℃ of hatchings of 2.5% potassium bichromate solution 48 hours, timing after the sporeization, 4 ℃ of preservations, standby in one month.
Test method, 220 of test chickens, 14 ages in days are divided into test group at random 1,2, No. 3.Each group respectively is divided into 0.5g, 1g, three kinds of dosetest groups of 2g again by the dispensing agent.Other establishes and infects not administration matched group and do not infect not administration matched group.Amount to 11 groups every group 20.All non-ball worm egg capsule and clinical manifestations on inspection before the infection.Each test group is all weighed in 14 ages in days, and begins to throw respectively the thing of taking medicine in 16 ages in days, serve on 7.During 18 ages in days, 5 * 10 in every chickling artificial challenge coccidiosis spore egg capsule of 1-10 group directly injects in the crop by syringe with sebific duct.Later on day by day the spirit of observed and recorded chicken, diet desire, feces situation observed and recorded 8 days, heavy during to the 9th day by the component another name, all cut open and kill, observe caecum lesion, get intestinal contents 2 grams of speaking in a low voice respectively, carry out the egg capsule counting with the Maxwell method, by angle Tian Qing (day) criterion calculation egg capsule value, according to survival rate, seven index evaluation prevention effects such as average weight, the relative weight gain rate, feces are kept the score, pathological changes value, anticoccidial index (ACI), egg capsule value.The results are shown in Table 1.
Show that by test palatability of drugs of the present invention is good, nontoxic pair of effect.During dispensing, chickling does not all have refuses the clothes performance, has no adverse reaction after the dispensing.With the matched group comparative result, three kinds of anticoccidial drugs of the present invention all have certain prevention effect, infect not administration group hemafecia heap number, to analyse variations, egg capsule counting all serious than infection administration group, rate of body weight gain, anticoccidial index are low.Wherein No. 2 effect of drugs are better than other two kinds.Simultaneously also as can be seen, three kinds of dosages all have the certain protection effect, and the protective rate of every 1 gram reaches 100%.
The clinical trial of prevention broiler coccidiosis is by the Shandong Province academy sciences Biology Research Institute and economize veterinary drug supervision Qihe County, place kind chicken house and carry out, and with excellent plain smart (Japan) with add good fortune (U.S. cyanogen waist company product) and contrast, Qihe County kind chicken house provides
Table 1 prevention chicken coccidiosis clinical effectiveness statistics
| Group | ?1?????2????3 | ?4????5????6 | ?7????8?????9 | ??10??????11 | |
| Number of elements | ???????20 | ??????20 | ??????20 | ??20??????20 | |
| Dosage | ?0.5???1????2 | ?0.5??1????2 | 0.5???1?????2 | ??A???????B | |
| Morbidity number death toll survival rate | ?4?????4????3??????3????2????1?????3?????3?????2?????19??????0 ?0?????0????0??????0????0????0?????0?????0?????0?????8???????0 ????????????????????????100?????????????????????????40??????100 ????????????????????????100?????????????????????????75??????0 ?75????75???75?????75???100??100???75????75????75????25??????0 ?50????50???75?????50???75???75????50????50????75????0???????0 ?25????25???50?????50???50???75????25????50????50????0???????0 ?16????16???17?????16???18???19????17????17????18????19??????20 ?3?????4????2??????3????2????1?????3?????2?????2?????9???????0 ?1?????0????1??????1????0????0?????0?????1?????0?????7???????0 ?0?????0????0??????0????0????0?????0?????0?????0?????2???????0 ?0?????0????0??????0????0????0?????0?????0?????0?????1???????0 ?4?????4????3??????4????2????1?????3?????3?????2?????19??????0 ?75????47???23?????47???21???7?????78????41????17????100?????0 ?20????10???5??????10???5????5?????20????10????5?????40??????0 | ||||
| Feces is kept the score | 5 days 6 days 7 days 8 days | ||||
| Lesion score | ?0 ?1 ?2％ ?3 ?4 | ||||
| Pathological changes value egg capsule is than number % egg capsule value | |||||
| Weightening finish g only | ??????1270??????1275??????1485???????1320????????1035 ?1315??????1335??????1335??????1185????????1395??????????1325 | ||||
| The relative weight gain % | ?36.8??????88.1??????88.8??????78.2????????92.1??????????100 ??????83.8??????84.8??????98?????????87.1????????80.3 | ||||
| The anticoccidial index | ?162.8?????180.2?????181.8?????155.2???????185.1?????????200 ??????169.8?????170.2?????192????????171.1???????49.3 | ||||
A infects not administration E for not infecting the AA commercial meat bird of 8000 1 ages in days of not administration, with raising under the condition to 8 ages in days, begins to be divided into 4 groups at random each 2500 of 1-3 groups, the 4th group 500.Drink medicine of the present invention by 0.05% for first group in drinking-water, second group is the blank group.Four groups are with feeding and management to 44 age in days under the condition, respectively grabbing 10 chickens at random at 1,8,15,22,29,36,45 ages in days weighs and focuses on 1,14,38,45 ages in days and adopt feces 5 gram at random, calculate gram feces egg sac number (O, P, G) with the MCmasters method, and observe the mental status, appetite, feces character and the record chicken death toll of chicken every day.The results are shown in Table 2, table 3.
The sampling demonstration of weighing, no significant difference between three dispensing groups, and significant difference between blank group and first three the dispensing group.Three kinds of coccidiostats all have the excellent prevention effect, and the prevention protective rate is even to reach 100%.Blank group sickness rate reaches 70%, and survival rate has only 78%, three kind of medicine all not find toxicity, and to take chicken group growing way of the present invention the most neat but observe from regularity, and survival rate is higher than other two groups.
Clinical trial the present invention of the Eimeria coccidiosis that prevents six kinds of characteristic of diseases of broiler also has been to artificial challenge's 10 * 10 at Qihe County kind chicken house in we and Shandong Province academy sciences Biology Research Institute
4Etc. the chickling of tender Eimeria egg capsule, can prevent the generation of coccidiosis effectively, caecum does not produce pathological changes, does not occur egg capsule in the feces, and weightening finish is had no adverse effects, and the anticoccidial index reaches the imported product level, and protective rate reaches 100%, the results are shown in Table 4.
In sum, the present invention through clinical effectiveness test and field test to multiple coccidiosis
Table 2 sampling weighing results (g of unit)
Table 3 stool examination result
Table 4 prevention meat chicken coccidiosis curative effect statistical table
Disease all has the good preventing effect, has broad spectrum activity, and protective rate reaches nontoxic pair of effect of 100% pair of fowl poultry, and drug residue free is easy to use, is a kind of veterinary drug of anticoccidial safely and efficiently.
| Group infects administration and infects not administration and do not dye and do not give | ||
| Number of elements drug dose morbidity number (only) sickness rate (%) death toll | ????50????????50??????????50 ????2ml???????0???????????0 ????0?????????45??????????0 ????0?????????90??????????0 ????0?????????20??????????0 ????100???????100?????????100 ????100???????75??????????75 ????75????????25??????????75 ????25????????0???????????25 ????100???????0???????????100 ????0?????????13??????????0 ????0?????????13??????????0 ????0?????????27??????????0 ????0?????????47??????????0 ????0?????????31??????????0 ????0?????????100?????????0 ????0?????????40??????????0 ????231???????150?????????235 ????99.6??????63.3????????100 ????183.8?????30.5????????200 | |
| Feces is kept the score | ????5 ????6 ????7 ????8 | |
| Lesion score % | ????0 ????1 ????2 ????3 ????4 | |
| Pathological changes value egg capsule is than g/ the relative weight gain % anticoccidial index of several 9% egg capsule value weightening finishes | ||
The several concrete instances of following reuse further specify the present invention, but are not confined to this several example formulations scopes.
Example 123
Component %
Herba Artemisiae Annuae 42 50 58
Crow dawn 12 10 8
Radix Dichroae 24 20 16
Radix Sanguisorbae 12 10 8
Radix Glycyrrhizae 10 10 10
Effect
Protection ratio 100 100 100
Poisoning all has no side effect
Claims (2)
1, a kind of medicine of coccidiosis is characterized in that it being the extract that includes Chinese medicine medicines prescriptions such as Herba Artemisiae Annuae, crow dawn, Radix Dichroae, Radix Sanguisorbae and Radix Glycyrrhizae, and the composition content of this Chinese herbal medicine is (weight %):
The 40-60 Herba Artemisiae Annuae
8-12 crow dawn
The 16-24 Radix Dichroae
The 8-12 Radix Sanguisorbae
The 8-12 Radix Glycyrrhizae
Above-mentioned constituent is respectively with ethanol and water extraction, and leaching liquid adds appropriate amount of starch after concentrating, said title medicine is made in the sucrose pelletize.
2,, it is characterized in that the Chinese medicine medicines constituent makes said coccidiosis medicine by following technology according to the described coccidiosis medicine production of claim 1 method:
A) five tastes Chinese herbal medicine such as Herba Artemisiae Annuae, crow dawn, Radix Dichroae, Radix Sanguisorbae, Radix Glycyrrhizae are mixed in proportion after, with 95% after alcohol-pickled 48 hours, leach soak;
B) solids moves in the frying pan, and water decocts twice, each 1.5 hours, leaches filtrate;
C) merge above-mentioned filtrate, the proportion that is evaporated to concentrated solution in concentration tank is 1.48;
D) concentrated solution adding starch, sucrose and ethanol are mixed back pelletize, oven dry thoroughly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 95112130 CN1145791A (en) | 1995-09-20 | 1995-09-20 | Coccidiosis-resisting Chinese herbal veterinary medicine and its prepn |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 95112130 CN1145791A (en) | 1995-09-20 | 1995-09-20 | Coccidiosis-resisting Chinese herbal veterinary medicine and its prepn |
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| Publication Number | Publication Date |
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| CN1145791A true CN1145791A (en) | 1997-03-26 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 95112130 Pending CN1145791A (en) | 1995-09-20 | 1995-09-20 | Coccidiosis-resisting Chinese herbal veterinary medicine and its prepn |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1294952C (en) * | 2003-09-03 | 2007-01-17 | 中国农业科学院上海家畜寄生虫病研究所 | Traditional Chinese medicine compound preparation for preventing and treating coccidiosis |
| CN101780115A (en) * | 2010-03-23 | 2010-07-21 | 河北农业大学 | Chinese veterinary medicine microcapsule preparation and preparation method thereof |
| CN102028105A (en) * | 2010-12-23 | 2011-04-27 | 内蒙古自治区农牧业科学院 | Preparation method of Artemisia annaua feed additive |
| CN103142766A (en) * | 2013-04-02 | 2013-06-12 | 河北工程大学 | Medicine for controlling coccidiosis in rabbits |
| CN103495091A (en) * | 2013-10-22 | 2014-01-08 | 山东新希望六和集团有限公司 | Traditional Chinese medicine immune stimulant for preventing Eimeria tenella infections |
| CN104274527A (en) * | 2014-10-10 | 2015-01-14 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicinal composition for treating eimeria disease of commercial broiler and preparation method thereof |
| CN105395644A (en) * | 2015-12-02 | 2016-03-16 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicinal composition for preventing and treating coccidiosis in chicken as well as preparation method and application of traditional Chinese medicinal composition |
| CN108542948A (en) * | 2018-07-16 | 2018-09-18 | 河南森隆动物保健品有限公司 | A kind of Chinese medicine composition and its Chinese medicine preparation for treating chicken coccidiasis |
-
1995
- 1995-09-20 CN CN 95112130 patent/CN1145791A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1294952C (en) * | 2003-09-03 | 2007-01-17 | 中国农业科学院上海家畜寄生虫病研究所 | Traditional Chinese medicine compound preparation for preventing and treating coccidiosis |
| CN101780115A (en) * | 2010-03-23 | 2010-07-21 | 河北农业大学 | Chinese veterinary medicine microcapsule preparation and preparation method thereof |
| CN102028105A (en) * | 2010-12-23 | 2011-04-27 | 内蒙古自治区农牧业科学院 | Preparation method of Artemisia annaua feed additive |
| CN103142766A (en) * | 2013-04-02 | 2013-06-12 | 河北工程大学 | Medicine for controlling coccidiosis in rabbits |
| CN103142766B (en) * | 2013-04-02 | 2014-09-03 | 河北工程大学 | Medicine for controlling coccidiosis in rabbits |
| CN103495091A (en) * | 2013-10-22 | 2014-01-08 | 山东新希望六和集团有限公司 | Traditional Chinese medicine immune stimulant for preventing Eimeria tenella infections |
| CN103495091B (en) * | 2013-10-22 | 2015-07-01 | 山东新希望六和集团有限公司 | Traditional Chinese medicine immune stimulant for preventing Eimeria tenella infections |
| CN104274527A (en) * | 2014-10-10 | 2015-01-14 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicinal composition for treating eimeria disease of commercial broiler and preparation method thereof |
| CN105395644A (en) * | 2015-12-02 | 2016-03-16 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicinal composition for preventing and treating coccidiosis in chicken as well as preparation method and application of traditional Chinese medicinal composition |
| CN108542948A (en) * | 2018-07-16 | 2018-09-18 | 河南森隆动物保健品有限公司 | A kind of Chinese medicine composition and its Chinese medicine preparation for treating chicken coccidiasis |
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