JP2003104901A - Composition for health promotion - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a composition effective for liver diseases such as hepatitis. SOLUTION: This composition is obtained by incorporating Angelica keiskei as an active ingredient. As secondary ingredients, other Chinese medicinal components effective for the liver diseases may also be incorporated.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a composition used for the purpose of maintaining, maintaining, promoting, or recovering health, and in particular, a composition containing Shinsen grass as an active ingredient.

[0002]

2. Description of the Related Art For the treatment of hepatitis, cirrhosis, liver cancer and the like, for example, interferon and hepatoprotective agents are used. Interferon is used as an antiviral agent that does not affect normal cells, but its effectiveness is said to be about 30% at the highest. In addition, there are side effects.

Hepatoprotectors have relatively few side effects,
It is used as a drug that can be injected and administered orally.
Such a hepatoprotective agent has an anti-inflammatory effect and is used as a hepatocyte destruction inhibitor, but its effectiveness is said to be about 30% or less at the highest by injection. It will be even lower in the case of oral administration. There is a strong demand for the development of drugs with even higher cure rates.

On the other hand, in recent years, the shift from hepatitis C to liver cancer has become a serious problem. About 8 transitions from hepatitis to liver cancer
It is said to be 0%. When liver cancer is reached, depending on its symptoms and stages, as described above, a drug with a high cure rate has not yet been developed, and in general, it is obligatory to resort to surgical treatment. The current situation.

[0005]

As the number of people who switch from hepatitis to liver cancer increases, there is an urgent need for measures to effectively treat the hepatitis. Furthermore, it is preferable if the transition to liver cancer can be delayed or prevented at the stage of hepatitis.

Although the medicinal effect may be prescribed as a medicine such as a medicine, it is more preferable that the patient can use it safely in daily life without using special knowledge. .

[0007] In recent years, there are relatively few side effects worldwide, compared with synthetic drugs of Western medicine, and mildly effective, and
Kampo has attracted attention as a drug that has a medicinal effect that cannot be achieved by synthetic drugs, and the present inventor also wondered if a search could be made from this point.

An object of the present invention is to provide a Kampo composition effective against liver diseases such as hepatitis.

[0009]

In view of the above problems, the present inventor has searched for a crude drug effective against liver diseases such as hepatitis. Currently, it is carried out in the world to search for medicinal properties that are effective as crude drugs from plants and the like.
The present invention has been completed for the first time by discovering that a medicinal effect is remarkably exhibited in liver diseases including hepatitis C in a plant called Shinsen grass in the local language.

That is, the health-directed composition of the present invention is
It is characterized by including Shinsen grass. The health-directed composition of the present invention is characterized by containing an extract from Shinsen grass.
The health-directed composition having such a constitution is characterized by being ingestible through the mouth.

The health-directed composition is characterized by being a drug or a drug raw material. Alternatively, the health-directed composition may be a quasi drug or a quasi drug raw material. Alternatively, the health-directed composition may be a food or foodstuff.

The health-directed composition contains, in addition to the Shinsengaku, a herbal medicine selected from the group of turmeric, nymph, daidai, cinnamon, chimpi, cinnamon and cinnamon, and / or an extract from the herbal medicine. It is characterized by having.

The health-oriented composition having any one of the above-mentioned constitutions is characterized in that it is a composition for liver disease used for prevention or treatment of liver disease. The health-directing composition having such a constitution is characterized in that it is provided in the form of any one of liquid, powder, granule, gel, tablet and capsule.

The health-oriented composition having the above-mentioned constitution is characterized in that it is a composition for treating a tumor. Alternatively, it may be a composition for treating bites. Alternatively, it may be a composition for treating burns.

The "health-oriented composition" in the present invention means a composition used for health purposes.
That is, the preservation, maintenance, or promotion of health,
Alternatively, it refers to a composition used for the purpose of achieving effects such as recovery alone or in combination of multiple effects.

Further, the term "health" in the health-oriented composition means not only physical health but also mental health. The meaning range of such a health-directed composition is, for example, specifically foods, food materials, health drinks, health foods, specific nutritional foods, pharmaceuticals, pharmaceutical raw materials, and also considering mental health. Quasi-drugs such as cosmetics, which may have a strong tendency to be a favorite product,
Alternatively, the range includes the raw materials.

The health-directing composition of the present invention can be used in such a manner that it can be taken from the mouth or applied to the skin for external application, injectable preparations, etc. Any form is acceptable.

Furthermore, the health-directed composition of the present invention may be considered to have a human health-directivity as a primary consideration.
However, application to animals other than human beings is not excluded, and it can be used as animal feed, feed, veterinary medicine, or raw materials thereof.

In the present invention, it is sufficient that the Shinsen grass is blended with the expectation that it will effectively function for treatment, health maintenance and the like, and the composition ratio of Shinsen grass in the composition does not matter.

[0020]

BEST MODE FOR CARRYING OUT THE INVENTION Embodiments of the present invention will be described in detail below with reference to Examples. The health-directed composition of the present invention contains Shinsen grass as an active ingredient. The Shinsengaku is native to the Korean Peninsula and China.

The inventor of the present invention investigated the medicinal effect of such an extract from Shinsen grass. Extraction from Shinsenso was performed according to the general prescription of Kampo. That is, the whole Shinsen grass was decocted, and the decoction was further boiled until it became viscous, and this was used as an extract. When investigating the drug efficacy, the viscous extract was used as it was, or the extract was used as a dry powder.

In the investigation of the drug efficacy, it was found that the drug is particularly effective for liver diseases. Therefore, the extract of Shinsen grass was powdered and administered to a person who exhibited symptoms of chronic hepatitis according to the following procedure, and the effectiveness was investigated.

[0023] In taking the dried powder of Shinsen grass extract, 10g of the dried powder of the Shinsen grass extract was taken three times in the morning, noon and evening for 3 to 6 months, and the results are shown in the following table. Efficacy is judged using the degree of GPT used in diagnosis of hepatitis, clinical tests, etc. in the blood of the subject as an index.

In the table, the symptoms disappeared within 40 days after administration,
A case where GPT dropped to a normal value was shown as markedly effective.
Within 60 days after taking the drug, those in which GPT dropped to a normal value and symptoms were improved were shown as effective. The efficacy of Shinsenso against hepatitis is calculated from the number of cases with both excellent response and efficacy.

[0025]

[Table 1]

From Table 1 above, it can be confirmed that when the dry powder of Shinsen grass extract is taken, the symptom is resolved at a high rate of 74%. In addition, in such a case, it is also confirmed that the GPT has fallen to the normal value. That is, the effect equivalent to the complete cure rate of hepatitis was obtained at a high rate of 74%.

On the other hand, although the symptom is not resolved,
The cases in which the symptoms were improved were confirmed in 13% of all the subjects. Although not shown in the table, the remaining 13% are G
The PT did not fall to the normal value.

As described above, it is presumed that Shinsengaku protects the destruction of liver cells in hepatitis from the effect of remarkably lowering the GPT value in hepatitis of Shinsengaku.
Although the details of the pharmacological mechanism are not known at this stage, it can be confirmed that Shinsengaku has an extremely effective pharmacological action against hepatitis.

The number of patients with liver diseases, especially hepatitis, is estimated to be about 2 million or more in Japan. Also, liver cancer
It occupies the 3rd to 4th place of cancer death, and an effective treatment method for it is highly desired. It is said that about 80% of such liver cancers are caused by hepatitis typified by hepatitis C.

The health-directed composition of the present invention contains, as an active ingredient, Shinsengaku, which exhibits extremely excellent drug efficacy against hepatitis as described above.
It can be provided in the form of health food or the like.

Regarding the medicinal effect of Shinsen grass, it showed a surprisingly effective rate for the above hepatitis.
The effect of attracting swelling such as pimples is recognized.
In addition, it is also effective against insect bites, bites such as insects and snakes. Furthermore, the effect of causing heat such as burns to suppress the swelling is also recognized.

[0032]

Example In this example, a health-directed composition having a prescription effective for hepatitis was prepared on the basis of the remarkable drug effect of the extract of Jinsenso grass on hepatitis.

In this example, the main composition of the health-directing composition according to the present invention can be set to, for example, Shinsen grass extract powder 150 to 180 parts by weight and turmeric extract powder 8 to 12 parts by weight.

Among the above-mentioned ingredients, turmeric extract powder is known in Chinese medicine as a strong liver agent or hepatoprotective agent in Kampo prescription for liver diseases. The composition of the present invention was compounded and formulated for the purpose of synergistic effect with Shinsen grass. That is, it was considered that even if the medicinal effect of Shinsengaku extract powder was not sufficiently manifested, it could be supplemented with turmeric extract powder in some cases.

In the above-mentioned combination prescription, a case was shown in which turmeric extract powder was added as an accessory ingredient for liver disease. However, the traditionally prescribed Kampo medicine for liver disease was replaced with turmeric extract powder, or You may use together with it.

In addition, in the above blending, a so-called pesticide may be blended for the purpose of exerting the effect of the Chinese medicine. It is generally prescribed in Kampo to enhance vitality and vitality. By adding such a qi agent, it was added for the purpose of a synergistic therapeutic effect from the aspect of qi.

Examples of such agents include peanut, red sea bream, red sea bream, cinnamon, cinnamon bark, cinnamon bark, chinpi and the like. At the time of compounding, a suitable amount of each of these vapors may be appropriately combined to prepare a mixture of a plurality of types, or a single compound may be formulated. In the health-directed composition of the present invention, the vapor is an optional ingredient.

[0038] As an example of formulation of the vapor, for example, 2-5 parts by weight of juniper powder, 2-5 parts by weight of daikon extract powder, 2-5 parts by weight of cinnamon extract powder may be blended as follows.

In the formulation of such a vapour, for example, cinnamon tree, cinnamon bark, and chimpi may be used in combination with the above vapour. Alternatively, all or any of the blended vapors described above may be replaced with these vapors.

In addition, from the viewpoint of difficulty in taking the powder, a prescription for providing the powder as a capsule or the like was set. In this case, crystalline cellulose and sucrose fatty acid ester, which have been conventionally used as a generally used excipient, were blended.

More specifically, the following compounding ratio can be set as the daily dose. Shinsen grass extract powder 0.5 g to 3 g (more preferably 1 to 2 g) Turmeric extract powder 50 mg to 1 g (more preferably 50 mg to 100 mg) peanut powder 5 mg to 1 g (more preferably 10 mg to 100 mg) Daidai extract powder 5 mg to 1 g (more preferably 10 mg to 100 mg) Cinnamon extract powder 5 mg to 1 g (more preferably 10 mg to 100 mg) Crystalline cellulose Appropriate amount sucrose fatty acid ester Appropriate amount For example, as described above, 0.5 g of Shinsen grass is used. Although it can be set to ~ 3 g, in order to reduce the daily dose to reduce the patient's burden as much as possible, for example, 1 g ~
It is preferably set to 2 g. The same applies to the case of blending a powder such as turmeric extract powder and juniper nut.

The above composition is premised to be provided as a capsule or the like, but for example, a liquid agent, an extract agent (soft extract agent, dry extract agent), elixir agent, syrup agent, granule agent, pill agent, It may be provided in various forms such as tablets, powders (powder), or gels. Upon formulation of each, the conventionally known excipients, binders or disintegrants, lubricants required for each,
A coating agent or the like may be used.

In the above description, the case of using the extract of Shinsen grass or the dry powder of the extract has been explained. However, whole or a part of the dry product of Shinsen grass is used alone or other dried herbal medicines. It can also be blended with and used as health tea or as a decoction.

As described above, the medicinal effects of Shinsengaku were extremely good for hepatitis, but it was also confirmed that a significant drop in GPT was found to improve the cases of such hepatitis. From these facts, it is speculated that the oral administration of the health-directing composition of the present invention strongly suppresses the destruction of hepatocytes. Therefore, from the viewpoint of suppressing the destruction of hepatocytes, it is considered that the health-directed composition of the present invention widely and effectively functions for liver diseases such as cirrhosis and liver cancer in addition to hepatitis.

In addition to such liver diseases, the following effective drug effects are exhibited. Therefore, for example, prescription as an external preparation may be considered. As the external preparation, a use form in which the Shinsengaku extract is dispersed in a hydrophobic base material or an ointment base material as a hydrophilic base material is considered.

If formed into such an external preparation, the product,
In the affected area of swelling such as pimples, or insect bites,
It can be applied to affected areas such as insects and snakes, bites such as snakes, burns, and wounds to improve the symptoms and show effects.

Furthermore, by adding the Shinsen herb extract to cosmetic creams, lotions, etc., it is possible to prevent the skin from being rashed by cosmetics and prevent inflammation.

The present invention is not limited to the description of the above embodiment, and various changes may be made without departing from the spirit of the present invention.

[0049]

EFFECTS OF THE INVENTION Since the health-directed composition of the present invention contains Shinsen grass which is effective against hepatitis, it can be used as a preventive or therapeutic drug for hepatitis.

Since the health-directed composition of the present invention contains Shinsen grass which is effective against hepatitis, when used as a food, a health food or a nutritional supplement, it prevents hepatitis in daily life. , Improvement or therapeutic effect can be obtained.

The Shinsen grass contained in the health-directed composition of the present invention has an effect of causing swelling of a rash, pimple, etc., and thus can be effectively used as an external preparation for causing such swelling. .

The Shinsen grass contained in the health-directed composition of the present invention is effective for treating bites of insect bites, insects, snakes, etc., and therefore can be effectively used as an external preparation for the treatment of bites. it can.

The Shinsen grass contained in the health-directed composition of the present invention effectively functions to eliminate the symptoms of the affected area such as burns, and thus can be effectively used as an external preparation for treating burns.

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Claims (12)

[Claims] 1. A health-directed composition comprising Shinsen grass. 2. A health-directed composition comprising an extract from Shinsen grass. 3. The health-directed composition according to claim 1, wherein the health-directed composition is ingestible through the mouth. 4. The health-directed composition according to claim 1, wherein the health-directed composition is a drug or a drug raw material. 5. The health-directed composition according to any one of claims 1 to 3, wherein the health-directed composition is a quasi drug or a quasi drug raw material. Health-oriented composition. 6. The health-directed composition according to claim 1, wherein the health-directed composition is a food or food material. 7. The health-directed composition according to any one of claims 1 to 6, wherein the health-directed composition is turmeric in addition to the Shinsen grass.
A health-directed composition comprising a crude drug selected from the group of pearl oysters, red sea bream, cinnamon, chimpi, cinnamon bark, cinnamon bark, and / or an extract from the crude drug. 8. The health-directed composition according to any one of claims 1 to 7, wherein the health-directed composition is a liver disease composition used for the prevention or treatment of liver disease. A health-directed composition comprising: 9. The health-directed composition according to any one of claims 1 to 7, wherein the health-directed composition is a composition for treating a tumor. . 10. The health-oriented composition according to claim 1, wherein the health-oriented composition is a composition for treating bites. . 11. The health-directed composition according to claim 1, wherein the health-directed composition is a composition for treating burns. . 12. The health-directed composition according to claim 1, wherein the health-directed composition is a liquid, powder, granule, gel, tablet, or capsule. A health-directed composition provided in the form of: