JP2010168399A - Pharmaceutical for controlling elevation of blood sugar - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a medicine which can stably control the progression of diabetes occupying the core of life-style related diseases. <P>SOLUTION: The medicine containing an extract taken out from at least the meat of oyster by hot water extraction or the like is used as a medicine for controlling the elevation of glycemia. Thus, a large effect for controlling the progression of diabetes without accompanying side effects is obtained. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a drug for suppressing an increase in blood sugar.

  Today, lifestyle-related diseases such as diabetes are spreading in developed countries in Europe and the United States, and Japan is no exception, and the rapid increase in lifestyle-related diseases associated with the westernization of the food environment has become apparent. As a result, the population of obesity and hyperglycemia is increasing rapidly.

  If hyperglycemia persists, it leads to arteriosclerosis, nephropathy, retinopathy, and other serious diabetic complications due to glycation reaction with intravascular proteins. Further, in a state where the sensitivity to insulin is decreased due to diabetes, hyperinsulinemia causes abnormal lipid metabolism and hyperlipidemia is induced.

As a drug for alleviating these symptoms, many compounds having an antihyperlipidemic action and a blood glucose lowering action have been reported to date (see Patent Document 1, etc.).
JP-A-8-40906

  However, many of the conventional ethical drugs with high therapeutic effects for diabetes are synthesized by chemical methods, and because of their nature, there are strong side effects and the problem of multiple toxicity due to multiple doses. Not suitable for long-term use.

  The present invention has been devised to solve such conventional problems, and its main purpose is to provide a drug that can safely suppress the progression of diabetes, which is the core of lifestyle-related diseases. There is to do.

  In order to achieve such an object, in the present invention, as an agent for suppressing an increase in blood sugar, an extract containing at least oyster meat extracted by hot water extraction or the like is used.

  According to such an extract of the present invention, an effect of suppressing an increase in blood sugar can be obtained, and thus a great effect can be obtained in suppressing the progression of a disease related to diabetes without causing side effects.

  The present invention is described in detail below.

  The medicine which shows the inhibitory action with respect to the disease accompanying the increase in blood glucose provided by this invention contains the extract extracted from the oyster. This oyster extract is made from oyster genus (Ostea gigas Thunb.) Such as beetle oysters, oysters, lobsters, etc., with shells or only meat taken and raw or dried and then ground. And extracted using a known extraction method such as hot water extraction.

  A liquid preparation can be obtained by concentrating the extract. Furthermore, a powder formulation can be obtained by spray-drying or freeze-drying this concentrated solution.

  In addition, since the well-known method can be applied about the extraction method and extraction method of the extract from an oyster, further description is abbreviate | omitted here.

  When the drug according to the present invention is used as a pharmaceutical, an effective amount of oyster extract for prevention or treatment is preferably formulated together with a pharmaceutically acceptable carrier or diluent. In addition, a binder, an absorption accelerator, a lubricant, an emulsifier, a surfactant, an antioxidant, an antiseptic, a colorant, a fragrance, a sweetener, and the like may be added.

  In such a pharmaceutical preparation, the blending ratio of the oyster extract, which is an active ingredient, to the carrier component is in the range of 1.0 to 80.0% by weight, particularly preferably in the range of 5.0 to 50.0% by weight.

  Pharmaceutical dosage forms include granules, fine granules, tablets, pills, capsules, sprays, solutions, suspensions, ointments, gels, pastes, creams, etc. As the administration route, various administration routes such as oral, intravenous, intramuscular, subcutaneous and articular cavity can be mentioned. Further, the dose and frequency of administration of the active ingredient can be appropriately changed according to the disease state, age, sex, administration route and the like.

  You may add the oyster extract by this invention to a chemical | medical agent. This drug refers to foods that are produced so as to fully exert physiological functions (tertiary functions) such as regulation of biological functions. For example, “Health and Nutrition Food Advisory Staff Textbook” (Heisei Heisei) As defined in July 30, 2015, published by Daiichi Shuppan Co., Ltd., pages 92, 93), it is defined as something different from so-called health foods as well as general foods. It is. The onset and progression of diabetes can be safely suppressed by taking a drug containing such an oyster extract in a timely manner.

  Next, the verification result of the blood glucose rise inhibitory effect of the chemical | medical agent containing the oyster extract by this invention is demonstrated.

  7 weeks old, female spontaneously hyperglycemic (KKAy) mice were subjected to blood glucose measurement and state observation while feeding solid chow during the preliminary breeding period (one week), and the average value of fasting blood glucose was almost constant. In this way, 10 animals were divided into 2 groups. Then, a suspension of solvent for one group (Control group) of each group and a suspension of oyster extract as a test substance for the other (test substance administration group) were each once continuously for 28 days. The blood glucose level during the administration period was collected from the orbital venous plexus at 10 am on the measurement day on the 7th, 14th and 21st days, and the fasting blood glucose level was measured. Was measured.

  In addition, the body weight ratio dose of the test substance was 200 mg / kg equivalent. Test results are expressed as mean ± standard deviation, and student's-t was used for the significance test.

  As a result, as shown in FIG. 1, the fasting blood glucose level of the positive control group that received only the suspension of the solvent, that is, the test substance was 140.01 mg / dl at the start of the test. On the other hand, after 21 days, diabetic blood glucose level of 230.10 mg / dl was exhibited, and it was further increased.

  In contrast, the fasting blood glucose level of the group administered with the test substance was 210.30 mg / dl on day 21 after administration, which is a significant (about −20 mg / dl) blood glucose rise inhibitory effect on the positive control group. After that, the increase in blood glucose was remarkably suppressed.

  As described above, it was demonstrated that a suspension containing an extract of oysters mainly extracted from meat has an effect of suppressing an increase in blood glucose in spontaneously hyperglycemic (KKAy) mice.

  The drug according to the present invention can be used for prevention, amelioration, or treatment of a disease accompanied by an increase in blood glucose selected from the group consisting of insulin-dependent diabetes and non-insulin-dependent diabetes.

It is a graph which shows the relationship between a blood glucose level raise and elapsed days.

Claims (1)

A drug for suppressing an increase in blood sugar,
A drug for suppressing an increase in blood glucose, characterized by containing an extract obtained by extracting raw materials of oyster meat together with shells, raw or dried and ground.

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