JP2004067557A - Medicine or functional food for controlling itch - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a medicine or a functional food which are effective for intractable itch, not to mention to common itch. <P>SOLUTION: The medicine is obtained by adding essence of oyster meat to an antipruritic agent for controlling itch. The essence of oyster meat is obtained by grinding oyster meat together with oyster shells or only oyster meat in a raw state as it is or drying and grinding and extracting the ground oyster meat with hot water. The functional food comprises the medicine. <P>COPYRIGHT: (C)2004,JPO

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a drug or functional food for suppressing itching.
[0002]
[Prior art]
Most skin diseases are usually accompanied by itching. The pruritus includes pruritus (general pruritus) that can be suppressed with commercially available antipruritic agents such as antihistamines, such as eczema and urticaria, and pruritus, senile pruritus, and atopy in hemodialysis patients. There are itchiness (refractory pruritus) that cannot be suppressed by antihistamines and steroids, such as atopic dermatitis. Is also one of the big problems.
[0003]
In addition, antipruritic agents mainly composed of antihistamines are not only ineffective for intractable pruritus, but also have the side effect of causing central depression such as sleepiness when used as an internal medicine.
[0004]
[Problems to be solved by the invention]
The present invention has been devised to solve such problems of the prior art, and its main purpose is to provide drugs or functional foods that are effective not only for general pruritus but also for intractable pruritus. It is to provide.
[0005]
[Means for Solving the Problems]
In order to achieve such an object, in the present invention, an oyster meat extract is contained in an antipruritic agent for suppressing itching.
[0006]
In particular, the oyster meat extract was obtained by extracting hot water from oyster meat that had been crushed raw or dried with shells or only meat. Moreover, the said chemical | medical agent shall be included in a functional food.
[0007]
DETAILED DESCRIPTION OF THE INVENTION
Hereinafter, the present invention will be described in detail with reference to the accompanying drawings.
[0008]
The drug showing an inhibitory action against general pruritus and refractory pruritus according to the present invention contains an extract from oyster meat. This oyster meat extract is made from oyster genus (Ostea gigas Thumb.) Meat such as beaked oysters, oysters, lobsters, etc., with shells or only meat, and raw or dried and crushed. It is obtained using a known extraction method such as hot water extraction.
[0009]
A liquid preparation can be obtained by concentrating the extract. Furthermore, a powder formulation can be obtained by spray-drying or freeze-drying this concentrated solution.
[0010]
In addition, since a well-known method can be applied about the extraction method and the purification method of the extract from oyster meat, description beyond this is abbreviate | omitted here.
[0011]
Next, the verification result of the antipruritic effect of the medicine containing the oyster meat extract according to the present invention will be described.
[0012]
First, a puppy animal model that induces general pruritus and refractory pruritus was made with mice, rats, and small animals such as guinea pigs. In particular, guinea pigs were optimal for observing pruritic behavior and skin scratch marks.
[0013]
More specifically, the hair on the right flank of a healthy Hartley male guinea pig (8 weeks old) was shaved with a clipper and a shaver the day before the experiment, and 0.05 ml of an irritant (general pruritus is histamine hydrochloride, refractory) For pruritus, porcine spleen-derived kallikrein) was applied intradermally to the site to cause itching, which was used as a rat model.
[0014]
As a result, it is possible to obtain a carrot animal model that can similarly determine the effect of pruritus against general pruritus that can be suppressed with commercially available antipruritic agents and refractory pruritus that cannot be suppressed with commercially available antipruritic agents.
[0015]
This model is divided into groups with an appropriate number of heads (for example, 12), and the pruritic behavior of each group is observed from directly above for a predetermined time (2 hours) immediately after administration with a video camera with a time display. The time during which the behavior (the scratched area was scratched with the mouth or hind limb) was accumulated (seconds / 120 minutes). At this time, it is possible to easily collect data by editing the video camera image so as to extract only the part where the pruritus is seen.
[0016]
As a result, as shown in FIG. 1, oyster meat extract having a concentration of 1% with respect to the first group in which the cumulative pruritus behavior time immediately after histamine germination was 18.8 ± 5.5 (seconds / 120 minutes) When applied, the cumulative pruritus behavior time was 11.4 ± 5.4 (sec / 120 min), showing a suppression rate of 39.4%, and the oyster meat extract was found to have a remarkable antipruritic effect. .
[0017]
In addition, as shown in FIG. 2, the oyster meat extract having a concentration of 1% was applied to the second group in which the cumulative pruritus behavior time immediately after kallikrein germination was 42.0 ± 6.0 (seconds / 120 minutes). When applied, the cumulative pruritus behavior time was 32.1 ± 4.1 (seconds / 120 minutes), showing a suppression rate of 23.6%, and at least for kallikrein gerbilization that cannot be suppressed at all by antihistamines. It has been demonstrated that an oyster meat extract having a concentration of 1% or more can provide an antipruritic effect almost equivalent to that for histamine pruritus.
[0018]
This test method is based on Shelley and Arthur, which is mainly organized by humans, “histamine germination can be suppressed with antihistamines (commercial antipruritic agents), but kallikrein germination cannot be suppressed with antihistamines” (Shelley WB, Arthur BP, Arch. Dermatol, 76, 296-323 (1957)) is applied to an animal model. By this test method, it is possible to determine whether or not there is an antipruritic effect on intractable pruritus caused by kallikrein occurrence as well as general occurrence due to histamine occurrence.
[0019]
When using the oyster meat extract according to the present invention, an effective amount of oyster meat extract for prevention or treatment may be formulated together with a pharmaceutically acceptable carrier or diluent. In addition, a binder, an absorption accelerator, a lubricant, an emulsifier, a surfactant, an antioxidant, an antiseptic, a colorant, a fragrance, a sweetener, and the like may be added.
[0020]
In such a preparation, the blending ratio of the oyster meat extract, which is an active ingredient, to the carrier component is in the range of 0.1 to 30.0% by weight, particularly preferably in the range of 0.5 to 5.0% by weight.
[0021]
Examples of dosage forms include distribution agents, sprays, solutions, suspensions, ointments, gels, pastes, creams, granules, fine granules, tablets, pills, capsules, etc. Examples of the administration route include various administration routes such as patching, coating, oral, intravenous, intramuscular, subcutaneous, and joint cavity, and an external preparation is particularly preferable. When the substance of the present invention is used as an external preparation for skin, usual components to be added to general external preparations for skin may be appropriately added as necessary. Further, the dose and frequency of administration of the active ingredient can be appropriately changed according to the disease state, age, sex, administration route and the like.
[0022]
The oyster meat extract according to the present invention can be applied to pharmaceuticals, quasi-drugs and cosmetics as external preparations, injections and internal medicines as disclosed in JP-A-3-287536. In that case, the substance of the present invention may be used in place of the zinc picolinate proposed in the publication.
[0023]
The oyster meat extract according to the present invention can be applied to all foods and drinks such as confectionery and soft drinks as a functional food comprising a natural product containing one or more nutrients and a processed product thereof.
[0024]
【The invention's effect】
As described above in detail, according to the present invention, it is possible to apply or externally apply a medicine or functional food containing an extract from oyster meat, thereby causing itching associated with general skin diseases such as eczema and urticaria (general Itch), as well as itching (refractory pruritus) such as skin pruritus, senile pruritus, and atopic dermatitis in hemodialysis patients that are difficult to suppress with conventional antipruritic agents (antihistamines and antiallergic agents) It can be safely suppressed without causing side effects such as drowsiness, and can have a great effect in effectively preventing, improving or treating skin symptoms.
[Brief description of the drawings]
FIG. 1 is a graph showing the effect on general bruising. FIG. 2 is a graph showing the effect on intractable bruising.

Claims (3)

A drug for suppressing itching, characterized by containing an extract from oyster meat. 2. The extract according to claim 1, wherein the extract is one obtained by hot water extraction from oyster meat with shells or only meat, raw or dried and crushed. Drugs. The functional food for suppressing the itch characterized by including the chemical | medical agent of Claim 1 or 2.

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