JP2006327996A - Medicine or functional food for controlling elevation of glycemia - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a medicine or functional food which can stably control the progression of diabetes occupying the core of life-style related diseases. <P>SOLUTION: A medicine or food containing an extract taken out from at least the meat of oyster by a hot water extraction or the like is used as a medicine or functional food for controlling the elevation of glycemia. Thereby, a large effect for controlling the progression of diabetes occupying the core of life-style related diseases without accompanying side effects is obtained. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a drug or functional food for suppressing an increase in blood sugar.

  Today, lifestyle-related diseases such as diabetes are spreading mainly in developed countries in Europe and the United States, and Japan is no exception, and the rapid increase in lifestyle-related diseases associated with the westernization of the food environment has become apparent. As a result, the population of obesity and hyperglycemia is increasing rapidly.

  If hyperglycemia persists, it leads to arteriosclerosis, nephropathy, retinopathy, and other serious diabetic complications due to glycation reaction with intravascular proteins. Further, in a state where the sensitivity to insulin is decreased due to diabetes, hyperinsulinemia causes abnormal lipid metabolism and hyperlipidemia is induced.

As a drug for alleviating these symptoms, many compounds having an antihyperlipidemic action and a blood glucose lowering action have been reported to date (see Patent Document 1, etc.).
JP-A-8-40906

  However, many of the conventional ethical drugs with high therapeutic effects for diabetes are synthesized by chemical methods, and due to their nature, there are strong side effects and the problem of multiple toxicity due to multiple doses. Not suitable for long-term use.

  The present invention has been devised to solve such conventional problems, and its main purpose is a drug or function that can safely suppress the progression of diabetes, which is the core of lifestyle-related diseases. To provide sex food.

  In order to achieve such an object, in the present invention, as an agent or functional food for suppressing an increase in blood sugar, the content of an extract extracted from at least meat of oysters by hot water extraction or the like is used. .

  According to such an extract of the present invention, an effect of suppressing an increase in blood sugar can be obtained, and thus a great effect can be obtained in suppressing the progression of a disease related to diabetes without causing side effects.

  The present invention is described in detail below.

  The drug or functional food showing an inhibitory action against a disease accompanied by an increase in blood glucose provided by the present invention contains an extract extracted from oysters. This oyster extract is made from oyster genus (Ostea gigas Thunb.) Such as beetle oysters, oysters, lobsters, etc., with shells or only meat taken and raw or dried and then ground. And extracted using a known extraction method such as hot water extraction.

  A liquid preparation can be obtained by concentrating the extract. Furthermore, a powder formulation can be obtained by spray-drying or freeze-drying this concentrated solution.

  In addition, since the well-known method can be applied about the extraction method and extraction method of the extract from an oyster, further description is abbreviate | omitted here.

  When the drug according to the present invention is used as a pharmaceutical, an effective amount of oyster extract for prevention or treatment is preferably formulated together with a pharmaceutically acceptable carrier or diluent. In addition, a binder, an absorption accelerator, a lubricant, an emulsifier, a surfactant, an antioxidant, an antiseptic, a colorant, a fragrance, a sweetener, and the like may be added.

  In such a pharmaceutical preparation, the blending ratio of the oyster extract, which is an active ingredient, to the carrier component is in the range of 1.0 to 80.0% by weight, particularly preferably in the range of 5.0 to 50.0% by weight.

  Examples of dosage forms of pharmaceutical preparations include granules, fine granules, tablets, pills, capsules, sprays, solutions, suspensions, ointments, gels, pastes, creams, etc. As the administration route, various administration routes such as oral, intravenous, intramuscular, subcutaneous and articular cavity can be mentioned. Further, the dose and frequency of administration of the active ingredient can be appropriately changed according to the disease state, age, sex, administration route and the like.

  The oyster extract according to the present invention may be added to functional foods. This functional food refers to foods that are manufactured to fully exert physiological functions (tertiary functions) such as adjustment of biological functions. For example, “Health and Nutrition Food Advisory Staff Textbook” (As of July 30, 2003, published by Daiichi Publishing Co., Ltd., pages 92, 93), it is defined as something different from so-called health foods as well as general foods. It is a thing. By taking a functional food containing such an oyster extract in a timely manner, the onset and progression of diabetes can be safely suppressed.

  Next, the verification result of the blood glucose rise inhibitory effect of the chemical | medical agent containing the oyster extract by this invention is demonstrated.

7 weeks old female spontaneously hyperglycemic (KKA ^y ) mice were subjected to blood glucose measurement and observation while feeding solid chow during the preliminary breeding period (one week), and the average fasting blood glucose level was almost constant. 10 animals were divided into 2 groups. Then, a suspension of solvent for one group (Control group) of each group and a suspension of oyster extract as a test substance for the other (test substance administration group) were each once continuously for 28 days. The blood glucose level during the administration period was collected from the orbital venous plexus at 10 am on the measurement day on the 7th, 14th and 21st days, and the fasting blood glucose level was measured. Was measured.

  In addition, the body weight ratio dose of the test substance was 200 mg / kg equivalent. Test results are expressed as mean ± standard deviation, and student's-t was used for the significance test.

  As a result, as shown in FIG. 1, the fasting blood glucose level of the positive control group that received only the suspension of the solvent, that is, the test substance was 140.01 mg / dl at the start of the test. On the other hand, after 21 days, diabetic blood glucose level of 230.10 mg / dl was exhibited and further increased.

  In contrast, the fasting blood glucose level of the group administered with the test substance was 210.30 mg / dl on day 21 after administration, which is a significant (about −20 mg / dl) blood glucose rise inhibitory effect on the positive control group. After that, the increase in blood glucose was remarkably suppressed.

As described above, it was demonstrated that a suspension containing an extract of oysters mainly extracted from meat has an effect of suppressing blood sugar elevation in spontaneously hyperglycemic (KKA ^y ) mice.

  The drug or functional food according to the present invention can be used for prevention, amelioration, or treatment of diseases associated with elevated blood glucose selected from the group consisting of insulin-dependent diabetes and non-insulin-dependent diabetes.

It is a graph which shows the relationship between a blood glucose level raise and elapsed days.

Claims (2)

A drug for suppressing an increase in blood sugar,
A drug for suppressing an increase in blood glucose, comprising an extract extracted from at least meat of oysters. A functional food for suppressing an increase in blood sugar,
A functional food for suppressing an increase in blood glucose, comprising an extract extracted from at least meat of oysters.

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