JP2009263385A - Internal medicine for controlling symptom of rhinitis of type i allergic disorder - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an internal medicine capable of inhibiting or moderating the unpleasant symptoms caused by a type I allergic disorder without accompanying harmful adverse effects. <P>SOLUTION: This internal medicine for inhibiting the symptoms of rhinitis of the type I allergic disorder contains an extract of the meat and shell of an oyster. The oyster meat extract is obtained by using the meat of Ostea gigas Thunb. such as Neopycnodonte cochlear, Crassostrea gigas, Ostrea denselamellosa, etc., together with the shells of them as raw or the dried and crushed material of them as a raw material and utilizing a method for extracting with hot water. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

The present invention relates to an internal medicine for suppressing the onset of rhinitis symptoms of type I allergic disease involving immunoglobulin E (IgE antibody).

For the treatment of type I allergic diseases of rhinitis caused by various antigenic substances such as house dust, pollen, spore spores, inhaled allergens, dietary allergens and drug allergens, antiallergic agents, antihistamines, nonsteroidal Anti-inflammatory agents, corticosteroid (steroid) agents and the like are generally used.

However, these conventional therapeutic agents for type I allergic diseases, for example, antihistamines may cause drowsiness (central depression) when taken, and steroids have more or less harmful side effects, such as rebound after use. It was inevitable to accompany the treatment.

The present invention has been devised to solve such conventional problems, and its main purpose is to suppress unpleasant symptoms caused by rhinitis of type I allergic disease without harmful side effects. It is to provide an internal medicine that can be used.

In order to achieve such an object, the internal medicine for suppressing the symptoms of rhinitis of type I allergic disease according to the first invention of the present application is characterized by containing an extract from oyster meat and oyster shells. To do.

The internal medicine for suppressing the symptoms of rhinitis of type I allergic disease according to the second invention of the present application contains an extract obtained by hot water extraction from raw or dried oyster meat together with shells. It is characterized by.

Since the internal medicine of the first and second inventions of the present application uses an extract from oyster meat and oyster shells, symptoms of type I allergic diseases are accompanied by side effects such as sleepiness and steroid rebound. Without being suppressed or mitigated safely.

The graph which shows the relationship between the grade of auricle thickening, and elapsed time.

Hereinafter, the present invention will be described in detail with reference to the accompanying drawings.

The internal medicine for suppressing the symptom of the rhinitis of the type I allergic disease in which the IgE antibody is involved according to the embodiment of the invention contains an extract from oyster meat and oyster shells. This oyster meat extract is made from raw oyster genus (Ostea gigas Thunb.) Meat such as beaked oysters, oysters, lobsters, etc., raw or dried and crushed after drying. It is obtained by using.

A liquid preparation can be obtained by concentrating the extract. Furthermore, a powder formulation can be obtained by spray-drying or freeze-drying this concentrated solution.

In addition, since a well-known method can be applied about the extraction method and the purification method of the extract from oyster meat, description beyond this is abbreviate | omitted here.

Next, a method for verifying the action of oyster meat extract to suppress and alleviate symptoms of type I allergic disease will be described.

First, healthy BALB / c female mice (5 weeks old) were divided into two groups of 5 mice per group, and one group was prepared by adding 100 mg of oyster meat extract to 5 ml of distilled water and stirring. The suspension solution was orally administered for 21 days in an amount equivalent to 200 mg / kg of the body weight of each individual, and only distilled water was administered to the control group under the same conditions. Feeding and water supply during the period of administration of the oyster meat extract were freely ingested.

On the next day after the 21 days from the administration, 0.5 ml of monoclonal anti-DNP IgE antibodies (PCA titer2, 560; manufactured by Seikagaku Corporation) was administered as an antigen substance in the tail vein for passive sensitization, and skin reaction with IgE antibody. Induced.

Then, 0.15% DNFB solution prepared by dissolving DNFB (dinitrofluorobenzene; manufactured by Hanai Chemical Industry Co., Ltd.) in an acetone-olive oil (4: 1) mixed solution was applied to the auricle of the mouse 1 hour after the induction to react the skin reaction. After the induction, the thickness of the auricle was measured with a dial thickness gauge (manufactured by Mitoyo) every 1, 4, 24, and 48 hours.

As a result, as shown in FIG. 1, the thickening of the auricles at each time point when 1,4, 24, and 48 hours had passed after applying the 0.15% DNFB solution, the control group to which only distilled water was given, Although they were 7.22 ± 0.35 (× 10−2 mm; mean value ± standard deviation), 3.44 ± 0.23, 4.78 ± 0.22, and 3.82 ± 0.22, respectively. On the other hand, in the group pre-administered with the oyster meat extract, they were 6.70 ± 0.27, 2.90 ± 0.16, 4.20 ± 0.33, and 3.56 ± 0.23, respectively.

That is, in the group of mice that had been pre-administered with the oyster meat extract, skin inflammation induced by passively sensitizing the IgE antibody and application of the DNFB solution was significantly suppressed compared to the group of mice that had not been administered. This indicates that the symptoms of type I allergic disease involving IgE antibody were suppressed and alleviated by oyster meat extract.

In order to use oyster meat extract for the prevention or treatment of rhinitis symptoms of type I allergic diseases, an effective amount of oyster meat extract for prevention or treatment may be formulated together with a pharmaceutically acceptable carrier or diluent. In addition, a binder, an absorption accelerator, a lubricant, an emulsifier, a surfactant, an antioxidant, an antiseptic, a colorant, a fragrance, a sweetener, and the like may be appropriately added to the internal medicine.

In such preparations, the blending ratio of the oyster meat extract, which is an active ingredient, to the carrier component is in the range of 0.1 to 30.0% by weight, particularly 0.5 to 5.0% by weight in the case of external preparations. %, And in the case of an internal preparation, it is in the range of 1.0 to 80.0% by weight, particularly preferably in the range of 5.0 to 50.0% by weight.

As dosage forms, granules, fine granules, tablets, pills, capsules, solutions, suspensions, gels, pastes, creams, ointments, distributions, and sprays depending on the symptoms As the administration route, various administration routes such as oral, intravenous, intramuscular, subcutaneous, joint cavity, external preparation, patch, and application can be mentioned. It is.

When oyster meat extract is used as an internal medicine, normal ingredients to be blended in general internal medicines may be appropriately blended as necessary. Further, the dose and frequency of administration of the active ingredient can be appropriately changed according to symptoms, age, sex, administration route and the like.

As described in detail above, according to the present invention, by taking an internal medicine containing an extract from oyster meat, the symptoms of rhinitis symptoms of type I allergic disease involving IgE antibody can be reduced to sleepiness and steroid rebound. It can be safely suppressed and mitigated without side effects such as. That is, according to the present invention, it is possible to prevent the onset of rhinitis, which is a type I allergic disease, and to have a great effect in improving and treating symptoms.

Claims (2)

An internal medicine for suppressing symptoms of rhinitis of type I allergic disease, characterized by containing an extract from oyster meat and oyster shells. An internal medicine for suppressing rhinitis symptoms of type I allergic disease, comprising an extract obtained by hot water extraction from raw oyster meat with shells or dried and pulverized.

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