JP2007131643A - Medicament for suppressing/mitigating symptom of allergic disease - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a medicament or a functional food for suppressing/mitigating unpleasant symptom of type-I allergic disease without accompanying harmful side effects. <P>SOLUTION: The medicament or the functional food comprises an essence obtained by extracting oyster meat with the shell or only the meat in a raw state or a dried and pulverized product with hot water. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a drug or functional food for suppressing or alleviating allergic diseases, and particularly effective for suppressing the onset of type I allergic diseases involving immunoglobulin E (IgE antibody) and alleviating symptoms. It relates to drugs or functional foods.

  Treatment of type I allergic diseases such as atopic dermatitis, rhinitis, hay fever and asthma caused by various antigenic substances such as house dust, pollen, spider spores, inhaled allergens, dietary allergens, and drug allergens In general, antiallergic agents, antihistamines, non-steroidal anti-inflammatory agents, corticosteroid (steroid) agents and the like are generally used.

  However, these conventional therapeutic agents for type I allergic diseases, for example, antihistamines may cause drowsiness (central depression) when taken, and steroids have more or less harmful side effects such as rebound after use. It was inevitable to accompany the treatment.

  The present invention has been devised to solve such conventional problems, and its main purpose is to suppress and alleviate unpleasant symptoms due to type I allergic diseases without harmful side effects. It is to provide a drug or functional food that can be used.

  In order to achieve such an object, the present invention is characterized in that a drug or functional food for suppressing or alleviating symptoms of allergic diseases contains an extract from oyster meat. .

  Alternatively, it contains an extract extracted from hot pulverized oyster meat with shells or meat, raw or dried, and pulverized with a drug or functional food for suppressing or alleviating the symptoms of allergic diseases. It was characterized by

  As a result, the symptoms of type I allergic disease are safely suppressed and alleviated without side effects such as sleepiness and steroid rebound.

  Hereinafter, the present invention will be described in detail with reference to the accompanying drawings.

  In the present invention, an extract from oyster meat is contained as a drug for suppressing or alleviating the symptoms of type I allergic diseases involving IgE antibodies. This oyster meat extract is made from oyster genus (Oste gigas Thunb.) Meat such as beaked oysters, oysters, lobsters, etc., with shells or only meat, and raw or dried and then ground. It is obtained using a known extraction method such as hot water extraction.

  A liquid preparation can be obtained by concentrating the extract. Furthermore, a powder formulation can be obtained by spray-drying or freeze-drying this concentrated solution.

  In addition, since a well-known method can be applied about the extraction method and the purification method of the extract from oyster meat, description beyond this is abbreviate | omitted here.

  Next, a method for verifying the action of oyster meat extract to suppress and alleviate symptoms of type I allergic disease will be described.

  First, healthy BALB / c female mice (5 weeks old) were divided into two groups of 5 mice per group, and one group was prepared by adding 100 mg of oyster meat extract to 5 ml of distilled water and stirring. The suspension solution was orally administered for 21 days in an amount equivalent to 200 mg / kg of the body weight of each individual, and only distilled water was administered to the control group under the same conditions. Feeding and water supply during the period of administration of the oyster meat extract were freely ingested.

  On the next day after the 21 days from the administration, 0.5 ml of monoclonal anti-DNP IgE antibodies (PCA titer2, 560; manufactured by Seikagaku Corporation) was administered as an antigen substance in the tail vein for passive sensitization, and skin reaction with IgE antibody. Induced.

  Then, a 0.15% DNFB solution prepared by dissolving DNFB (dinitrofluorobenzene; manufactured by Hanai Chemical Industries) in an acetone-olive oil (4: 1) mixture was applied to the auricle of the mouse 1 hour after induction to react the skin reaction. After the induction, the thickness of the auricle was measured with a dial thickness gauge (manufactured by Mitoyo) every 1, 4, 24, and 48 hours.

As a result, as shown in FIG. 1, the thickening of the auricles at each time point when 1,4, 24, and 48 hours had passed after applying the 0.15% DNFB solution, the control group that received only distilled water, The values were 7.22 ± 0.35 (× 10 ⁻² mm; mean ± standard deviation), 3.44 ± 0.23, 4.78 ± 0.22, and 3.82 ± 0.22, respectively. On the other hand, in the group pre-administered with the oyster meat extract, they were 6.70 ± 0.27, 2.90 ± 0.16, 4.20 ± 0.33, and 3.56 ± 0.23, respectively.

  That is, in the group of mice that had been pre-administered with the oyster meat extract, skin inflammation induced by passively sensitizing the IgE antibody and application of the DNFB solution was significantly suppressed compared to the group of mice that had not been administered. This indicates that the symptoms of type I allergic disease involving IgE antibody were suppressed and alleviated by oyster meat extract.

  In order to use oyster meat extract for prevention and treatment of type I allergic diseases, it is preferable to formulate an amount of oyster meat extract effective for prevention and treatment together with a pharmaceutically acceptable carrier or diluent. In addition, a binder, an absorption accelerator, a lubricant, an emulsifier, a surfactant, an antioxidant, an antiseptic, a colorant, a fragrance, a sweetener, and the like may be appropriately added to the drug.

  In such preparations, the blending ratio of the oyster meat extract, which is an active ingredient, to the carrier component is in the range of 0.1 to 30.0% by weight, particularly 0.5 to 5.0% by weight in the case of external preparations. % Is preferable, and in the case of an internal preparation, the range is 1.0 to 80.0% by weight, and particularly preferably 5.0 to 50.0% by weight.

  As dosage forms, granules, fine granules, tablets, pills, capsules, solutions, suspensions, gels, pastes, creams, ointments, distributions, and sprays depending on the symptoms The administration route includes various administration routes such as oral, intravenous, intramuscular, subcutaneous, joint cavity, external preparation, patch, and application. It is good.

  When using the oyster meat extract as an internal preparation, it is only necessary to appropriately add the usual ingredients mixed in a general internal preparation as necessary. Further, the dose and frequency of administration of the active ingredient can be appropriately changed according to symptoms, age, sex, administration route and the like.

  The oyster meat extract can be included in any food and drink such as confectionery and soft drinks as a functional food consisting of a natural product containing one or more nutrients and processed products thereof. Can be taken in a timely manner to suppress the onset of type I allergic disease and relieve symptoms.

  As described above in detail, according to the present invention, by applying a medicine containing an extract from oyster meat internally or externally, or by ingesting a functional food containing an extract from oyster meat, atopy Symptoms of type I allergic diseases involving IgE antibodies represented by dermatitis, rhinitis, hay fever and asthma can be safely suppressed and alleviated without side effects such as sleepiness and steroid rebound. That is, according to the present invention, it is possible to prevent the onset of type I allergic disease and to have a great effect in improving and treating symptoms.

A graph showing the relationship between the degree of pinna thickening and the elapsed time

Claims (4)

A drug for suppressing or alleviating symptoms of allergic diseases, characterized by containing an extract from oyster meat. A drug for suppressing or alleviating symptoms of allergic diseases, characterized by containing an extract obtained by hot water extraction from raw or dried crushed oyster meat with shells or only meat. A functional food for suppressing or alleviating symptoms of allergic diseases, characterized by containing an extract from oyster meat. A functional food for suppressing or alleviating symptoms of allergic diseases, characterized by containing an extract obtained by hot water extraction from raw or dried crushed oyster meat with shells or only meat.

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