CN103211096A - Anti-coccidium traditional Chinese medicine feed additive - Google Patents
Anti-coccidium traditional Chinese medicine feed additive Download PDFInfo
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Abstract
The invention relates to an anti-coccidium traditional Chinese medicine feed additive. The additive is characterized in that the compatibility of all the traditional Chinese medicines is in accordance with a traditional Chinese medicine theory, radix notoginseng, rhizoma arisaematis, fructus aurantii, salt and borneol serve as monarch drugs, cortex meliae, ulmus macrocarpa hance, semen pharbitidis, portulaca oleracea and Chinese pulsatilla root serve as adjuvant drugs, earthworm, radix linderae leaves, semen aesculi, hupeh anemone herb and agilawood serve as adjuvants, and gentiana davidii franch, folium isatifis, carrot, soybean and mint serve as conductant drugs. The additive has the effects of expelling worms, insecticiding, stopping bleeding, detoxifying, diminishing inflammation and the like as well as an obvious treatment effect on livestock coccidium prevention.
Description
Technical field
The present invention relates to the field of Chinese medicines, specifically a kind of Chinese herbal feed additive of anticoccidial.
Background technology
Global-worm illness is a kind of parasitic disease, can cause poultry meat and egg production heavy losses to occur.Parasite in small intestine at double propagation cause stoping damage, reduce nutrient absorbing rate in feed intake and the feed, dehydration and blood loss.Global-worm illness is a kind of by unicellular parasite Eimeria(Amy ear) cause.The life cycle of Eimeria approximately is 4-7 days.When the egg capsule of activity searched for food by chicken engulf after the life of Eimeria just begun.One " egg capsule " is that a capsule has the thick protective layer of one deck protecting parasite.They be " spore " or do not have infective, if but humidity, temperature or oxygen are suitable, they just begin growth.After chicken searched for food egg capsule, coccidia is implantation in enteron aisle, be entrenched between the enterocyte several at double the breeding after, damaging tissue.
At present main use sulfamido is arranged, the spirit of ball dysentery, clopidol, Robenidine, Amprolium hydrochloride, Nicarbazin, furazolidone, halofuginone hydrobromide, fluoropurine, diclazuril, hundred balls are clear, diformazan thiamines, quinolines etc.
Chemical synthetic drug is complicated to the mechanism of action of coccidia, the chemistry anticoccidial drug has a wider field of activity usually, and is high-effect, but has the bigger potential that develops immunity to drugs, only can produce limited immunity, sometimes also there is toxicity, and more expensive than ionophore class drug price usually.
Summary of the invention
The Chinese herbal feed additive that the purpose of this invention is to provide a kind of anticoccidial.
A kind of Chinese herbal feed additive of anticoccidial is characterized in that, is made up of the raw material of following weight portion:
Pseudo-ginseng 1-10 part, rhizoma arisaematis 1-10 part, Fructus Aurantii 1-10 part, salt 1-5 part, borneol 1-5 part, azedarach 5-15 part, fructus ulmi 5-15 part, kaladana 5-15 part, purslane 5-15 part, Chinese bulbul 5-15 part, earthworm 10-20 part, combined spicebush leaf 10-20 part, buckeye 10-20 part, anemone vitifolia 10-20 part, agalloch eaglewood 10-20 part, david gentian herb 15-25 part, folium isatidis 15-25 part, carrot 15-25 part, soya bean 15-25 part, peppermint 15-25 part;
A, elder generation crystallize into powder with anemone vitifolia, david gentian herb distillation;
B, get the surplus stock medicine again and put into alcohol immersion, heat is extracted 2 times, becomes the medicinal extract shape, is component 1;
C, dregs of a decoction extracting in water 1 time, thickening filtration are the medicinal extract shape, are component 2;
D, above-mentioned two kinds of medicinal extract are condensed into pasty state, add the powder that a step obtains, add honey and be twisted into pill.
As preferably, it is characterized in that, among the described step b, get bulk drug and add 60-90% alcohol immersion 1-2 hour that 5-10 doubly measures, heating is extracted 2 times, each 1-2 hour, get supernatant, merge extract, the 80-120 order filters, and is the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, 1.36 medicinal extract when the concentrated relative density of ultrafiltrate decompression is 80 ℃, heating concentrates, and 30 minutes～45 minutes, extracts active component, concentrate is settled into pasty state, mass continues heating and is concentrated into the medicinal extract shape, and stand for standby use becomes component 1;
As preferably, it is characterized in that among the described step c, the dregs of a decoction add 5-10 times of water gaging and soaked 1-2 hour, extract 1 time in 1-1.5 hour, as component 2.
Adding 20-30% in the feed gets final product.
A kind of Chinese herbal feed additive of anticoccidial is characterized in that, is made up of the raw material of following weight portion:
Pseudo-ginseng 2-8 part, rhizoma arisaematis 2-8 part, Fructus Aurantii 2-8 part, salt 2-4 part, borneol 2-4 part, azedarach 6-14 part, fructus ulmi 6-14 part, kaladana 6-14 part, purslane 6-14 part, Chinese bulbul 6-14 part, earthworm 12-18 part, combined spicebush leaf 12-18 part, buckeye 12-18 part, anemone vitifolia 12-18 part, agalloch eaglewood 12-18 part, david gentian herb 16-24 part, folium isatidis 16-24 part, carrot 16-24 part, soya bean 16-24 part, peppermint 16-24 part.
A kind of Chinese herbal feed additive of anticoccidial is characterized in that, is made up of the raw material of following weight portion:
5 parts of pseudo-ginseng, 5 parts of rhizoma arisaematis, 5 parts of Fructus Aurantiis, 3 parts of salt, 3 parts of borneols, 10 parts of azedaraches, 10 parts of fructus ulmis, 10 parts of kaladanas, 10 parts of purslanes, 10 parts of the Chinese bulbuls, 15 parts of earthworms, 15 parts of combined spicebush leafs, 15 parts of buckeyes, 15 parts of anemone vitifolias, 15 parts of agalloch eaglewood, 20 parts of david gentian herbs, 20 parts of folium isatidis, 20 parts in carrot, 20 parts of soya beans, 20 parts of peppermints.
The all flavor drug matching of the present invention meets tcm theory, pseudo-ginseng, rhizoma arisaematis, Fructus Aurantii, salt, borneol are monarch drug in a prescription, azedarach, fructus ulmi, kaladana, purslane, the Chinese bulbul are ministerial drug, earthworm, combined spicebush leaf, buckeye, anemone vitifolia, agalloch eaglewood are adjutant, david gentian herb, folium isatidis, carrot, soya bean, peppermint make medicine, have effects such as expelling parasite, desinsection, hemostasis, detoxifcation, anti-inflammatory, remarkable to poultry anticoccidial result of treatment.
The present invention relates to the pharmacology and the property of medicine of Chinese medicine:
Pseudo-ginseng:
[meridian distribution of property and flavor] is warm in nature, sweet, the little hardship of flavor.
The ripe product of [effect] pseudo-ginseng still have the merit of enriching blood and invigorating blood circulation.
Rhizoma arisaematis:
[meridian distribution of property and flavor] is bitter, hot, temperature; Poisonous.Return lung, liver, the spleen channel.
[function cures mainly] is eliminating dampness and eliminating phlegm, expellings wind and relieving convulsion mass dissipating and swelling eliminating.Be used for stupid productive cough and cough, anemophlegmatic vertigo, apoplexy phlegm is stopped up, facial paralysis, hemiplegia, epilepsy, infantile convulsion, lockjaw.Give birth to controlling carbuncle outward and swell snake bite and insect sting.
Fructus Aurantii:
The nature and flavor hardship; Acid; Cold nature
Gui Jing: lung; Spleen; Liver; Stomach; Large intestine channel
Function cures mainly: chest diaphragm ruffian is full; The distending pain in hypochondrium; Accumulation of food in the stomach and intes tine due to indigestion; Abdominal fullness and distention; Heavy behind the diarrhea; Prolapse of the anus; The prolapse of uterus.
Borneol:
[meridian distribution of property and flavor] flavor is hot, bitter, is slightly cold; The thoughts of returning home, spleen, the lung hydrocarbon.
[function] inducing resuscitation of having one's ideas straightened out, clearing away heat to and alleviating pain.
Salt:
[meridian distribution of property and flavor] is salty, cold, nontoxic; Stomach, kidney, lung, liver, large intestine; Small intestinl channel.
[function cures mainly] emetic therapy, relieve inflammation or internal heat, cool blood, detoxifcation, soft heavily fortified point, desinsection, antipruritic; Cure mainly: food stops phlegm addiction, constipation and anuresis, gingiva bleeding gingival hemorrhage, laryngalgia, toothache, order screen, sore, insect bite in Shangwan, trusted subordinate's abdominal distension, the brain.
Azedarach:
Not [nature and flavor] " not Lu ": " be slightly cold." " Japan hanako materia medica ": " hardship, little poison." " the medical center nationality is wanted ": " is big bitter, Great Cold."
[function cures mainly] heat-clearing, eliminating dampness, desinsection.Control roundworm, pinworm, rubella, mange.
[pharmacological action]
1, anthelmintic action: show that through the pig test this medicine decoction or alcohol extract all have inhibition so that the paralysis effect to ascaris suum.The active ingredient of driving the ascarid effect is toosendanin, and is stronger than the effect of ethanol extract.The toosendanin of low concentration (1:5000-9000), whole piece ascaris suum and sections (head and middle part) thereof there is tangible excitation, showing as spontaneous activity strengthens, unusual violent contraction appears off and on, destroy its laws of motion (movable strengthen with weaken alternate), continue 10-24 hour, change spastic contraction at last gradually over to.Toosendanin can see through the polypide epidermis, directly acts on roundworm muscle, upsets its energetic supersession, causes contraction fatigue and spasm.The melia toosendan rope of this concentration is not blocked by atropine the excitation of roundworm nerve-muscle, and the prompting toosendanin is not a cholinomimetic.The toosendanin of high concentration (l:1000) to ascaris suum particularly the neuromere of head the paralysis effect is arranged.This paralysis effect may be that polypide is subjected to be the result that intermittent cramp shrinks behind the drug effect.Measure the cholinesterase activity of polypide homogenate respectively and breathe glycolysis through Ammon method and Warburg apparatus, result's proof does not all have obviously influence, shows that toosendanin is not to work by glycometabolism.In addition in the experimental result of ATP from roundworm muscle and Phos as can be seen, toosendanin can make the catabolism of ATP accelerate, thereby causes roundworm that the energy short supply is arranged and cause fatigue of contraction, and is excreted.The azedarach soup (25%-50%) of high concentration also has the paralysis effect external to the mouse pinworm.
2, to the influence of respiratory center:Heavy dose of toosendanin (every rat, vein or intramuscular injection 2mg) can cause rats breathing depletion.This mainly is owing to the inhibitory action of this composition to maincenter.Medulla oblongata respiratory center position directly gives toosendanin (every rat 0.10-0.15mg), can support The above results.The respiration inhibition that the central stimulant nikethamidum causes toosendanin has slight antagonism
3, to the influence of neuromuscular propagation function: toosendanin has rat and irreversibly checks the contraction of muscle that indirect stimulation causes, but the excitement that does not affect the nerves conduction does not reduce the reaction of muscle to direct stimulation yet; Toosendanin is 1 and optionally acts on presynaptic neuromuscular transmission blocking agent.Its site of action is at the presynaptic nerve endings, and the mode of action is the acetylcholine release that suppresses to excite nerve and bring out.Electron microscope observation shows that toosendanin has tangible effect to the submicroscopic structure of small white mouse neuromuscular junction, shows that the synaptic cleft width increases and the synaptic vesicle decreased number.These two kinds of variations do not appear at same joint simultaneously
4, anti-botulismus: toosendanin has therapeutic action to the botulismus animal.To the mouse of lethal dose A type botulismus, poisoning gave toosendanin in back 6 hours, and obvious therapeutic action is arranged; To the monkey of lethal dose A type botulismus, poisoning gave toosendanin in back 24 hours, can cure animals more than half; To the mouse of Type B botulismus, toosendanin also has protective effect.In addition, toosendanin can obviously strengthen the therapeutic action of antitoxic serum to botulismus mouse and rabbit
5, to the influence of heart nipple myoelectricity and mechanical property:The time-histories (APD 90) of fast response current potential multipole to 90% is prolonged the plain concentration dependent of chinaberry, block Ik1 with barium chloride, can cancel the effect that toosendanin prolongs APD90, long response time electricity e Huai Pian PD is prolonged toosendanin and convergent force (FC) strengthens, behind barium chloride, can cancel the above-mentioned effect of toosendanin, but prolong the effect existence of APD.In addition, toosendanin can make isolated frog heart shrink allorhythmia, can recover automatically in lasting l hour
6, other effects:Chinaberry element (200mg/kg) rabbit filling stomach and concentration are that the toosendanin of 0.2 * 10(-4) mg all has remarkable increase to the tension force and the convergent force of rabbit on the throne and isolated rabbit intestines.Concentration is that the toosendanin of 0.2 * l0(-3) mg can make myenteron present spastic contraction.This excitation can be resisted by diphenhydramine, and is not blocked by atropine.10% azedarach infusion has inhibitory action to multiple pathogenic fungus.Melia extract for treating mouse experiment Manson's schistosomiasis, the aspects such as borer population and hatching test of living from the animal body internal memory confirm that certain curative effect is arranged.
Peppermint:
[meridian distribution of property and flavor] is cool in nature, flavor is hot;
The effect of [function] anti-irritant causes tracheae to produce new secretion, and makes the mucus of stiff be easy to get rid of, thus have eliminate the phlegm, the effect of sterilization.
It is one of Chinese conventional Chinese medicine.It is hot cold sweating and heat resolving medicine, controls influenza, headache, hot eyes, body heat, throat, gum disease such as swell and ache.The place is with controlling neuralgia, pruitus, fash and eczema etc.The peppermint of light friend Greenhouse Fruit Picking is again the fresh vegetable on the dining table in the Spring Festival.Clearly good to eat.Usually with peppermint for tea, clearing away heart-fire makes eye bright.Peppermint has extremely strong sterilization antibacterial action, often drinks it and can prevent virus flu, mouth disease, makes breath freshening.Gargle with mint tea juice, can prevent halitosis.Steam face, the effect in the fine, soft fur hole of contracting in addition with the mint tea mist.Take the blade that steeped tea to apply and on eyes, can feel refrigerant, can remove eye fatigue.It is said that peppermint also has the another name of " eyes grass ", can be used for treating eye illness.
Fructus ulmi:
[meridian distribution of property and flavor] is hot, bitter, and be flat.
[function cures mainly] eliminating stagnated food to destroy intestinal worms.Be used for infantile malnutrition, roundworm disease, enterobiasis.
The kaladana:
[nature and flavor] are cold in nature, bitter; Poisonous.
[return through] returns lung channel, kidney channel, large intestine channel.
The defaecation of [function cures mainly] water pouring, drink is washed in dissolving phlegm, and desinsection is attacked long-pending.Be used for the oedema turgor, constipation and anuresis, phlegm and retained fluid is gathered, and the circulation of vital energy in the wrong direction is breathed with cough, abdominal pain due to enterositosis, roundworm, taeniasis.
Purslane:
[meridian distribution of property and flavor] acid, cold; Return liver, large intestine channel.
[function cures mainly] is applicable to dysentery (it is half-dried partly rare to defecate), clearing heat and detoxicating, cooling blood and hemostasis.Be used for toxic-heat and blood stasis, the carbuncle furunculosis that swells, eczema, erysipelas, snake bite and insect sting is had blood in stool, hemorrhoid blood, metrostaxis.Modern times are used for the treatment of enteritis, acute arthritis, cystitis, urethritis, architis, hemorrhoid hemorrhage etc. mostly.Collective Notes to the Canon of Materia medica " Bencao Tujing " is come from textual criticism: purslane, have another name called five-element's grass, and with its leaf green grass or young crops, obstruct redly, brightly yellowish, root is white, and son is deceived also.Cure mainly: hot poison rushes down dysentery; Heat is drenched; Renal shutdown; Leukorrhea with reddish discharge; Uterine bleeding; Hemorrhoid blood; Sore carbuncle furuncle; Erysipelas; Scrofula; Wet tinea; Bald in vain." the southern regions of the Yunnan Province book on Chinese herbal medicine ": beneficial gas, clear hot summer weather, the wide middle therapeutic method to keep the adverse qi flowing downward, ease constipation, it is stagnant to disappear, and desinsection is treated the sore congestion and swelling pain.
The Chinese bulbul:
[nature and flavor] bitter, cold in nature; Return stomach, large intestine channel;
[return through] returns stomach through, large intestine channel;
[function] has clearing heat and detoxicating, removes heat from the blood and relieve diarrhea the effect of removing dampness and destroying parasites.
[curing mainly] pyrotoxic dysentery disease, nosebleed epistaxis, bleeding, under the band, pruritus vulvae, carbuncle sore, scrofula.
Earthworm:
[nature and flavor] its flavor is salty, cold in nature.
[function] is heat-clearing, antispastic, Zhichuan, diuresis.Cure mainly high fanatical hot-tempered, convulsion, headache hot eyes, the diseases such as phlegm heat, apoplexy, hemiplegia of panting.Conventional Chinese medicine in the diseases such as damp invasion of lower energizer urinary tract infection such as Chinese traditional treatment prostate, this side is an ancient prescription among the people.Earthworm provides gets liquid the good effect that cloperastine is breathed heavily of deciding is arranged.The earthworm ash is controlled baldness with the attar of rose mixing energy.
The protein content of earthworm accounts for 53.5% ~ 65.1% of dry weight, and fat content is about 4.4% ~ 17.38%, and carbohydrate is about 11% ~ 17.4%, moisture 7.8% ~ 23%.Also contain abundant vitamin D (account for bright body weight 0.04% ~ 0.073%) in the earthworm body, and mineral matter element such as calcium and phosphorus (account for bright body weight 0.124% ~ 0.188%).The earthworm body contains multiple medicinal ingredients such as earthworm element, earthworm toxolysin, xanthine, antihistaminicum and Cobastab.Simultaneously, earthworm also is the intermediate host of some parasite such as nematode and tapeworm, as strongylid behind ring fine rule worm and the lunge etc.
Combined spicebush leaf:
[meridian distribution of property and flavor] is hot, temperature is gone into lung, spleen, kidney three warps;
In [effect cures mainly] temperature, regulate the flow of vital energy pain relieving.Control abdomen syncope due to pathogenic cold pain, the sliding number of urine, dyspepsia, rheumatic arthritis.
Root of three-nerved spicebush compatibility effectiveness: root of three-nerved spicebush compatibility agalloch eaglewood root of three-nerved spicebush warming kidney for dispelling cold, promoting qi circulation and relieving pain; Agalloch eaglewood be amusing appetizing, turbid, the promoting qi circulation and relieving pain of clearing dampization. two medicines share, and flat branch, reach the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, the effect cold, promoting qi circulation and relieving pain of loosing that having is amusing, with uncomfortable in chest, the abdominal distension of what treatment stagnation of liver-QI with deficiency of the spleen, breathe hard, disease such as weak, vomiting.
Root of three-nerved spicebush compatibility Radix Angelicae Sinensis root of three-nerved spicebush Xin Kaiwentong, promoting qi circulation and removing obstruction in the collateral, eliminating cold to stop pain, flat partially branch; The hot Wen Yun that looses of Radix Angelicae Sinensis, nourshing blood and promoting blood circulation, menstruction regulating and pain relieving are walked blood system partially. and the two 5 usefulness, the effect of playing the promoting flow of qi and blood circulation, diffusing cold antalgic altogether is with the diseases such as dysmenorrhoea, postpartum abdominal pain and cold hernia of what treatment cold obstruction causing qi stagnation blood stasis.
Root of three-nerved spicebush compatibility banksia rose root of three-nerved spicebush promoting qi circulation and relieving pain is loose cold, the long what temperature part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels cold-dampness of loosing; Banksia rose promoting qi circulation and relieving pain, merit are arrogated to oneself the capable taste stagnation of the circulation of vital energy. and two medicine mutual reinforcements between are usefulness, and the effect of its cold, promoting the circulation of qi of loosing, pain relieving is more outstanding, belongs to the obstructed person of the stagnation of the circulation of vital energy with abdominal distention and functional disturbances of gastrointestinal tract due to the what treatment cold obstruction causing qi stagnation.
Root of three-nerved spicebush compatibility Longstamen Onion Bulb root of three-nerved spicebush promoting qi circulation and relieving pain is loose cold; The Longstamen Onion Bulb promoting the circulation of qi that activates yang and remove abstruction. the two 5 usefulness, the effect that promoting the circulation of qi activates yang, pain-relieving powder for treating is cold is arranged, disease is seen uncomfortable in chest, pain person with the obstruction of qi in the chest due to turbid the stagnating of what treatment cold sensation of the genitalia phlegm.
Root of three-nerved spicebush compatibility fructus alpiniae oxyphyllae root of three-nerved spicebush warming kidney for dispelling cold; The fructus alpiniae oxyphyllae kidney tonifying urine that contracts. the two 5 usefulness, warming and invigorating kidney Yang is arranged, the effect of the cold urine that contracts that looses, treat the frequent micturition, the enuresis of decline of kidney-YANG etc. with what.
Agalloch eaglewood:
[meridian distribution of property and flavor] is hot, bitter, temperature.Return spleen, stomach, kidney, lung channel
In [effect] sending down abnormally ascending temperature, warm kidney is received gas.
[curing mainly] controlled the circulation of vital energy in the wrong direction and panted, the vomiting hiccup, and abdominal distention, waist knee void is cold, and large intestine void is secret, and urine gas drenches man's cold sperm.1. " not Lu ": " it be swollen to treat the geomantic omen poison, removes bad odor.”
Buckeye:
[nature and flavor with return through] are sweet, temperature.Return liver, stomach warp.
[function cures mainly] regulating the flow of QI to ease the stomach, and stomach and alleviating pain.It is vexed to be used for chest abdominal distension, gastral cavity pain.In wide, regulate the flow of vital energy desinsection.Control stomach cold and have a pain, abdominal fullness and distention, infantile malnutrition due to digestive disturbances or intestinalparasites worm pain, malaria, dysentery.1. " beneficial portion square object is note slightly ": " eat wind contraction for a long time." 2. " logical refined ": " can the therapeutic method to keep the adverse qi flowing downward." 3. " detailed outline is picked up any lost article from the road ": " the inherited from one's ancestors side of Pueraria lobota controls heart stomach cold pain, the worm pain.The therapeutic method to keep the adverse qi flowing downward in wide is controlled gastral cavilty liver diaphragm and is expanded infantile malnutrition due to digestive disturbances or intestinalparasites malaria dysentery, haematemesis internal lesion caused by overexertion, flat stomach vein relaxing.”
Anemone vitifolia:
[meridian distribution of property and flavor] toil, cold, poisonous.Return spleen; Stomach; Large intestine channel, stem, leaf: bitter, hot, temperature.Very toxic.Root: hardship, temperature.Poisonous.1. " Shaanxi Chinese herbal medicine ": " hardship, cold, slightly poisonous." 2. " Chinese herbal medicine is used in Sichuan always ": " and toil, temperature, slightly poisonous.”?
[chemical composition of Chinese materia medica] root and herb contain Anemonin (anemonin) and triterpene soap oleanolic acid-3-O-β-D-ribopyranose base-(1 → 3)-α-L-rhamnopyranosyl-(1 → 3)-α-L-arabopyranose glucoside, oleanolic acid 3-O-β-D-ribopyranose base-(1 → 3)-α-L-rhamnopyranosyl-(1 → 2)-β-D-xylopyranose glucoside, and oleanolic acid.
[function cures mainly] herb is mashed and is dropped in manure pit or the sewage, kills maggot, wriggler.Stem, leaf: desinsection; Control stubborn dermatitis.Eliminate indigestion, detumescence, the stasis of blood of loosing.Control stubborn dermatitis, the favus of the scalp, malaria, infantile malnutrition, dysentery, carbuncle furuncle sore is swollen, and scrofula, traumatic injury be " Shaanxi Chinese herbal medicine " 1.: " clearing heat and detoxicating, apocenosis myogenic, the diffusing stasis of blood of detumescence, promoting digestion and removing indigestion, preventing malaria, desinsection.Control stubborn dermatitis, the favus of the scalp, furuncle sore carbuncle is swollen, nameless sores or boils, malaria, dysentery, infantile malnutrition, indigestion, traumatic injury." 2. " Chinese herbal medicine is used in Sichuan always ": " detumescence is loose malicious.Control the traumatic injury redness, scrofula sore, dysentery diarrhoea.”
David gentian herb:
[nature and flavor] are cool in nature, bitter.
[function] is clearing heat and detoxicating, and diuresis makes eye bright; Control pyogenic osteomyelitis, urinary tract infections, conjunctivitis, furuncle, carbuncle.
Folium isatidis:
[nature and flavor] gas is cold, and mildly bitter flavor is salty."
[return through] goes into liver, the heart, stomach warp.
[function] heat-clearing, detoxifcation, cool blood, hemostasis.Control warm disease heat and contain polydipsia, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas is spitted blood bleeding from five sense organs or subcutaneous tissue, jaundice, dysentery, larynx numbness, aphtha, swollen ulcer drug.Folium isatidis is mainly used in the heat poison and sends out diseases such as spot, erysipelas, abscess of throat, aphthae, sore and toxic.
Carrot:
[nature and flavor] flavor is sweet, and property is flat.
[return through] goes into lung, the spleen channel.
[function cures mainly] reinforcing spleen to promote digestion, tonifying liver make eye bright, clearing heat and detoxicating, promoting eruption, sending down abnormally ascending cough-relieving.Being used for infantile malnutrition, measles, yctalopia, constipation, hypertension, digestive discomfort, protracted dysentery, full sulks expands etc.Carrot contains nutrients such as more vitamin C, B1, B2, is described as " popular genseng ".
Soya bean:
Motherland's medical science is thought, takes soya bean and can make us the longue skin, and beneficial color, the replenishing essence marrow, reinforcement gas, the qi-restoratives appetizing is the help food that suitable valetudinarian, invalid uses, and has nourishing qi and blood. during invigorating the spleen is wide, the peaceful heart of body-building, following sharp large intestine, the effect of moisturizing the water that disappears.
The specific embodiment:
Embodiment 1, prescription:
Pseudo-ginseng 1g, rhizoma arisaematis 1g, Fructus Aurantii 1g, salt 1g, borneol 1g, azedarach 5g, fructus ulmi 5g, kaladana 5g, purslane 5g, Chinese bulbul 5g, earthworm 10g, combined spicebush leaf 10g, buckeye 10g, anemone vitifolia 10g, agalloch eaglewood 10g, david gentian herb 15g, folium isatidis 15g, carrot 15g, soya bean 15g, peppermint 15g;
A, elder generation crystallize into powder with anemone vitifolia, david gentian herb distillation;
B, get the surplus stock medicine again and put into alcohol immersion, heat is extracted 2 times, becomes the medicinal extract shape, is component 1;
C, dregs of a decoction extracting in water 1 time, thickening filtration are the medicinal extract shape, are component 2;
D, above-mentioned two kinds of medicinal extract are condensed into pasty state, add the powder that a step obtains, add honey and be twisted into pill.
As preferably, it is characterized in that, among the described step b, get bulk drug and add 60-90% alcohol immersion 1-2 hour that 5-10 doubly measures, heating is extracted 2 times, each 1-2 hour, get supernatant, merge extract, the 80-120 order filters, and is the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, 1.36 medicinal extract when the concentrated relative density of ultrafiltrate decompression is 80 ℃, heating concentrates, and 30 minutes～45 minutes, extracts active component, concentrate is settled into pasty state, mass continues heating and is concentrated into the medicinal extract shape, and stand for standby use becomes component 1;
As preferably, it is characterized in that among the described step c, the dregs of a decoction add 5-10 times of water gaging and soaked 1-2 hour, extract 1 time in 1-1.5 hour, as component 2.
Adding 20-30% in the feed gets final product.
Embodiment 2, prescription:
Pseudo-ginseng 2g, rhizoma arisaematis 2g, Fructus Aurantii 2g, salt 2g, borneol 2g, azedarach 6g, fructus ulmi 6g, kaladana 6g, purslane 6g, Chinese bulbul 6g, earthworm 12g, combined spicebush leaf 12g, buckeye 12g, anemone vitifolia 12g, agalloch eaglewood 12g, david gentian herb 16g, folium isatidis 16g, carrot 16g, soya bean 16g, peppermint 16g.
The preparation method is identical with embodiment 1.
Embodiment 3, prescription:
Pseudo-ginseng 5g, rhizoma arisaematis 5g, Fructus Aurantii 5g, salt 3g, borneol 3g, azedarach 10g, fructus ulmi 10g, kaladana 10g, purslane 10g, Chinese bulbul 10g, earthworm 15g, combined spicebush leaf 15g, buckeye 15g, anemone vitifolia 15g, agalloch eaglewood 15g, david gentian herb 20g, folium isatidis 20g, carrot 20g, soya bean 20g, peppermint 20g.
The preparation method is identical with embodiment 1.
Embodiment 4, prescription:
Pseudo-ginseng 8g, rhizoma arisaematis 8g, Fructus Aurantii 8g, salt 4g, borneol 4g, azedarach 14g, fructus ulmi 14g, kaladana 14g, purslane 14g, Chinese bulbul 14g, earthworm 18g, combined spicebush leaf 18g, buckeye 12-18g, anemone vitifolia 12-18g, agalloch eaglewood 12-18g, david gentian herb 16-24g, folium isatidis 24g, carrot 24g, soya bean 24g, peppermint 24g.
The preparation method is identical with embodiment 1.
Embodiment 5, prescription:
Pseudo-ginseng 10g, rhizoma arisaematis 10g, Fructus Aurantii 10g, salt 5g, borneol 5g, azedarach 15g, fructus ulmi 15g, kaladana 15g, purslane 15g, Chinese bulbul 15g, earthworm 20g, combined spicebush leaf 20g, buckeye 20g, anemone vitifolia 20g, agalloch eaglewood 20g, david gentian herb 25g, folium isatidis 25g, carrot 25g, soya bean 25g, peppermint 25g;
The preparation method:
By formula rate above-mentioned Chinese medicine is chosen only, dries, dried and be ground into 300-400 purpose fine powder and soaked 100 days in adding vinegar, with ultrasonic wave homogenize 10-30 minute, packing was finished product under 0-10 ℃ of temperature.
Adding 20-30% in the feed gets final product.
Feed addictive of the present invention can mix with taking a tonic or nourishing food to build up one's health other feed ingredients of using in the food (hereinafter referred to as feed) with pet food, pet, as feed.Composition beyond the kind of feed is not particularly limited.Feed is preferably domestic animal or pet is used.
Feed of the present invention can be added into feed ingredient with undressed feed addictive, mixes to make to form.At this moment, if use feed addictive Powdered, the solid shape, for easy mixing also can be made feed addictive liquid state or gel.At this moment, can be with water, soybean oil, rapeseed oil, corn wet goods vegetable oil, liquid animal oil, polyvinyl alcohol or water-soluble high-molecular compounds such as PVP, polyacrylic acid as liquid-carrier.
Feed of the present invention can also contain carbohydrate (lactose, trehalose etc.), corn, Chinese sorghum, wheat bran, rice bran, defatted rice bran, dried bran, barley flake, cornflakes, dregs of beans, corn flour, ground rice, soy meal etc.Their concentration in feed is preferably 1～90 quality %, more preferably 5～75 quality %, more preferably 10～50 quality %.
In addition, feed of the present invention can also further contain the active ingredient that promotes domestic animal or pet to grow up, one-tenth that the nutritional supplementation composition improves storage stability any composition that grades.Any composition so for example can be bacteria-promoting agents such as enterococcus class, bacillus category, Bifidobacterium class, Bacillus acidi lactici class; Enzyme such as amylase, lipase; Vitamins such as Choline Chloride, inositol, folic acid; Mineral matters such as potassium chloride, ironic citrate, phosphoric acid salt; Amino acid such as DL-alanine, DL-methionine, L lysine HCL; Organic acids such as fumaric acid, butyric acid, lactic acid, acetic acid and its esters; Antioxidant such as ethoxyquinoline, dibutyl hydroxy toluene; Mould inhibitor such as propionic acid, sodium propionate; Binding agents such as CMC, casein-sodium, Sodium Polyacrylate; Fatty acid glyceride, dehydration sorb
Emulsifying agents such as sugar alcohol fatty acid ester; Pigment such as astaxanthin, canthaxanthin; Spices such as various esters, ether, ketone.
Feed of the present invention is applicable to the raising of domestic animals such as ox, pig, chicken or pet.The amount of feed of picked-up can be graded according to the one-tenth of the kind of animal, body weight, age, sex, health status, feed and suitably be regulated, and makes it to absorb the method and the method for breeding of feed, can adopt normally used method according to the kind of animal.
Analysis of experiments, conclusion are summed up:
1. materials and methods:
Coccidian oocyst mixed liquor: contain tender day Eimeria, poison Eimeria, Eimeria maxima and 4 kinds of heap type Eimeria, with 1:1:1:1 ratio mixing, be made into the coccidiosis vaccine liquid of 1,000,000 egg capsule/ml with 2.5% potassium bichromate solution.
2. test grouping and processing:
One group: the coccidian oocyst mixed liquor is fully shaken up, draws 2ml and join in the 1000ml drinking-water, from different directions (clockwise, counterclockwise, up and down) stir repeatedly; Take by weighing Chinese herbal feed additive 10g of the present invention, slowly add in the above-mentioned coccidian oocyst liquid, the limit edged from different directions (clockwise, counterclockwise, up and down) stir repeatedly, dissolve fully until Chinese medicine additive, coccidian oocyst liquid in the pasty state.
Two groups: take by weighing the anticoccidial preparation 20g of certain company, slowly join in the 1000ml drinking-water, from different directions (clockwise, counterclockwise, up and down) stir repeatedly; Dissolve fully until Chinese medicine additive,
The coccidian oocyst mixed liquor is fully shaken up, draws 2ml and join in the above-mentioned solution, from different directions (clockwise, counterclockwise, up and down) stir repeatedly.
Three groups (blank group): the coccidian oocyst mixed liquor is fully shaken up, draws 2ml and join in the 1000ml drinking-water, from different directions (clockwise, counterclockwise, up and down) stir repeatedly.
Draw every group of supernatant liquid 15ul respectively at 0h, 1h, 2h, 4h, 6h, 10h with liquid-transfering gun, place blood counting chamber to carry out the egg capsule counting, count from 6 sample point imbibitions at every turn, get its mean value for every group.
The result:
Chinese medicine additive of the present invention can make coccidian oocyst be suspended in uniformly in the drinking-water and can keep the above and not sedimentation of 6h; And the anticoccidial preparation of certain company during to 2h egg capsule descended 67.1%.
Conclusion shows treating and preventing coccidiosis agent of the present invention, the additive that contains this treating and preventing coccidiosis agent and feed, can prevent and treat animal (particularly domestic animal, pet) global-worm illness.
Claims (4)
1. the Chinese herbal feed additive of an anticoccidial is characterized in that, is made up of the raw material of following weight portion:
Pseudo-ginseng 1-10 part, rhizoma arisaematis 1-10 part, Fructus Aurantii 1-10 part, salt 1-5 part, borneol 1-5 part, azedarach 5-15 part, fructus ulmi 5-15 part, kaladana 5-15 part, purslane 5-15 part, Chinese bulbul 5-15 part, earthworm 10-20 part, combined spicebush leaf 10-20 part, buckeye 10-20 part, anemone vitifolia 10-20 part, agalloch eaglewood 10-20 part, david gentian herb 15-25 part, folium isatidis 15-25 part, carrot 15-25 part, soya bean 15-25 part, peppermint 15-25 part;
The preparation method:
A, elder generation crystallize into powder with anemone vitifolia, david gentian herb distillation;
B, get the surplus stock medicine again and put into alcohol immersion, heat is extracted 2 times, becomes the medicinal extract shape, is component 1;
C, dregs of a decoction extracting in water 1 time, thickening filtration are the medicinal extract shape, are component 2;
D, above-mentioned two kinds of medicinal extract are condensed into pasty state, add the powder that a step obtains, add honey and be twisted into pill;
Wherein, among the step b, get bulk drug and add 60-90% alcohol immersion 1-2 hour that 5-10 doubly measures, heating is extracted 2 times, each 1-2 hour, gets supernatant, merge extract, the 80-120 order filters, and is the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, 1.36 medicinal extract when the concentrated relative density of ultrafiltrate decompression is 80 ℃, heating concentrates, 30 minutes～45 minutes, extract active component, concentrate is settled into pasty state, mass continues heating and is concentrated into the medicinal extract shape, stand for standby use becomes component 1;
Wherein, among the step c, the dregs of a decoction add 5-10 times of water gaging and soaked 1-2 hour, extract 1 time in 1-1.5 hour, as component 2.
2. the Chinese herbal feed additive of a kind of anticoccidial according to claim 1 is characterized in that, is made up of the raw material of following weight portion:
Pseudo-ginseng 2-8 part, rhizoma arisaematis 2-8 part, Fructus Aurantii 2-8 part, salt 2-4 part, borneol 2-4 part, azedarach 6-14 part, fructus ulmi 6-14 part, kaladana 6-14 part, purslane 6-14 part, Chinese bulbul 6-14 part, earthworm 12-18 part, combined spicebush leaf 12-18 part, buckeye 12-18 part, anemone vitifolia 12-18 part, agalloch eaglewood 12-18 part, david gentian herb 16-24 part, folium isatidis 16-24 part, carrot 16-24 part, soya bean 16-24 part, peppermint 16-24 part.
3. the Chinese herbal feed additive of a kind of anticoccidial according to claim 1 is characterized in that, is made up of the raw material of following weight portion:
5 parts of pseudo-ginseng, 5 parts of rhizoma arisaematis, 5 parts of Fructus Aurantiis, 3 parts of salt, 3 parts of borneols, 10 parts of azedaraches, 10 parts of fructus ulmis, 10 parts of kaladanas, 10 parts of purslanes, 10 parts of the Chinese bulbuls, 15 parts of earthworms, 15 parts of combined spicebush leafs, 15 parts of buckeyes, 15 parts of anemone vitifolias, 15 parts of agalloch eaglewood, 20 parts of david gentian herbs, 20 parts of folium isatidis, 20 parts in carrot, 20 parts of soya beans, 20 parts of peppermints.
4. according to the Chinese herbal feed additive of any described a kind of anticoccidial of claim 1-3, it is characterized in that, the preparation method chooses above-mentioned Chinese medicine only, dries, dries and be ground into 300-400 purpose fine powder and soaked 100 days in adding vinegar by formula rate, with ultrasonic wave homogenize 10-30 minute, packing was finished product under 0-10 ℃ of temperature.
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| CN104996743A (en) * | 2014-07-25 | 2015-10-28 | 王卫华 | Making method of ferret badger special feed |
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| CN105010776A (en) * | 2014-07-25 | 2015-11-04 | 王卫华 | Method for producing ferret-badger pellet feed |
| CN104273392A (en) * | 2014-07-25 | 2015-01-14 | 王卫华 | Special formula granular feed for ferret badgers |
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| CN105533233A (en) * | 2015-12-18 | 2016-05-04 | 杜小卫 | Traditional Chinese medicine feed formula for preventing and treating parasitic diseases of poultry |
| CN106578375A (en) * | 2016-11-29 | 2017-04-26 | 南宁学院 | Feed additive for preventing coccidiosis of gooses |
| CN107279535A (en) * | 2017-07-12 | 2017-10-24 | 江苏隆达生物科技有限公司 | A kind of feed addictive and production method for newborn piglet expelling parasite |
| CN107279535B (en) * | 2017-07-12 | 2019-01-04 | 江苏隆达生物科技有限公司 | A kind of feed addictive and production method for newborn piglet expelling parasite |
| CN112006187A (en) * | 2020-10-14 | 2020-12-01 | 甘肃农业大学 | Anti-coccidiosis feed additive for large-scale ecological chicken raising and preparation and use methods thereof |
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