CN103212015B - Pharmaceutical composition for preventing avian influenza and preparation method thereof - Google Patents
Pharmaceutical composition for preventing avian influenza and preparation method thereof Download PDFInfo
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- CN103212015B CN103212015B CN201310128429.4A CN201310128429A CN103212015B CN 103212015 B CN103212015 B CN 103212015B CN 201310128429 A CN201310128429 A CN 201310128429A CN 103212015 B CN103212015 B CN 103212015B
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Abstract
The invention discloses a pharmaceutical composition for preventing avian influenza and a preparation method of the pharmaceutical composition, and belongs to the technical field of veterinary medicines. The pharmaceutical composition is prepared into mixture or oral liquid by taking the raw material medicines of hyperforin perforatum, rhizoma atractylodis, tsaoko amomum fruit, wild buckwheat, patrinia and the like, respectively extracting active ingredients according to different properties of the medicines by adopting water extraction, distillate reception and the other modes. The pharmaceutical composition has the effects of clearing away heat and toxic materials and is mainly used for treating avian influenza.
Description
Technical field
The invention belongs to veterinary medicine thing technical field, be specifically related to a kind of pharmaceutical composition of preventing and treating bird flu and preparation method thereof.
Background technology
Bird flu is a kind of height contagious disease of the poultry that caused by A type influenza virus (AIV) and wild fowl, has another name called European fowl plague, fowl plague.Primary disease was found in Italy first in 1878, almost spread all over all over the world at present, had multiple sick type, and wherein acute septic bird flu mortality rate can be up to more than 90%.Generally there is not the serious disease that influenza virus causes in the birds that freely circle in the air, but AIV exists multiple birds, and wild fowl is the huge warehouse of influenza virus, and this warehouse becomes the even source of human infection AIV of multiple poultry, mammal.Highly pathogenic, the strong infectiousness of bird flu causes huge, uncertain loss to aviculture, there is successively in recent years bird flu to occur and popular report all over the world, there is high pathogenic avian influenza in Korea S, Japan, Thailand, Vietnam, China some areas etc. in the recent period, serious threat, to development and the human health of aviculture, is therefore worth paying much attention to for the control of this disease.
Bird flu has the features such as pathogenicity, popularity, propagation complexity and pathogenic multiformity.Palpation is disconnected really depends on viral separation and evaluation for bird flu, and the symptom of avian influenza and pathological changes are very extensive, and clinical diagnosis is often supposition property, makes a definite diagnosis and must rely on viral separation, evaluation and serological test to differentiate.
The traditional Chinese medical science thinks that bird flu the disease appearing in blood system and edema caused by disorder of QI, intenseness of heat enter blood, the absurd row of forcing blood, and internal organs are hemorrhage.Excessive noxious heat, the cloudy Tianjin of calcination, day thirsty happiness drink, heat attacking the pericardium, stagnation of phlegm envelope, mind is covered, and enteral becomes under scorching urgent Tianjin, therefore see just rare.Chinese herbal medicine is abundant at Chinese Resources, cheap.For chemical synthetic drug, Chinese herbal medicine has plurality of active ingredients, not only have advantages of that toxicity is low, be difficult for having side effects, many target spots, pathogenic microorganism be difficult for producing drug resistance to it, and order is in anti-bacteria and anti-virus, can also promote growth of animal, strengthen the immune function of animal, improve body disease-resistant power.
Summary of the invention
The object of this invention is to provide a kind of Traditional Chinese medicine composition of preventing and treating bird flu and preparation method thereof, i.e. a kind of effect with heat-clearing and toxic substances removing, for the pharmaceutical composition of antiviral, anti-avian influenza;
The present invention makes after adopting Herba Hyperici perforati, Rhizoma Atractylodis, Fructus Tsaoko, Rhizoma Fagopyri Dibotryis, Herba Hyperici Japonici, Herba Patriniae, Rhizoma Et Radix Notopterygii according to certain compatibility processing, adopt respectively water extraction and receive the mode effective component extractings such as distillate according to medicine heterogeneity, making mixture or oral liquid.Pharmaceutical composition prepared by the present invention has the potent of heat-clearing and toxic substances removing, clinical remarkable for prevention and treatment bird flu effect.
The pharmaceutical composition of control bird flu of the present invention, its crude drug composition and parts by weight proportioning are as follows:
180～220 parts of Herba Hyperici perforatis, 180～220 parts of Rhizoma Atractylodis, 130～170 parts of Fructus Tsaokos, 130～170 parts of Rhizoma Fagopyri Dibotryiss, 80～120 parts of Herba Hyperici Japonici, 80～120 parts of Herba Patriniae, 80～120 parts of Rhizoma Et Radix Notopterygiis.
The crude drug composition and ratio of pharmaceutical composition of the present invention is preferably:
200 parts of Herba Hyperici perforatis, 200 parts of Rhizoma Atractylodis, 150 parts of Fructus Tsaokos, 150 parts of Rhizoma Fagopyri Dibotryiss, 100 parts of Herba Hyperici Japonici, 100 parts of Herba Patriniae, 100 parts of Rhizoma Et Radix Notopterygiis.
Pharmaceutical composition of the present invention can be made any in mixture or oral liquid.
The present invention adopts with the following method preparation: gets Rhizoma Atractylodis, Fructus Tsaoko, Rhizoma Et Radix Notopterygii, adds the water of 6～8 times of amounts of medical material weight, and distillation extraction, and receive the distillate of 3 times of amounts of medical material weight, for subsequent use; In medicinal residues, add Herba Hyperici perforati, Rhizoma Fagopyri Dibotryis, Herba Hyperici Japonici, Herba Patriniae, add the water of 8～12 times of medical material weight, extract 1～3 time, each 2 hours, filter, when filtrate decompression is concentrated into 60 ℃, measuring relative density is 1.10～1.15, let cool, add ethanol to reaching 50～70%, hold over night containing alcohol amount, filter, decompression filtrate recycling ethanol, to without alcohol taste, adds above-mentioned distillate, adds sodium benzoate appropriate, mix, to obtain final product.
Inventor further preferably preparation method is as follows: gets Rhizoma Atractylodis, Fructus Tsaoko, Rhizoma Et Radix Notopterygii, adds the water of 7 times of amounts of medical material weight, and distillation extraction, and receive the distillate of 3 times of amounts of medical material weight, for subsequent use; In medicinal residues, add Herba Hyperici perforati, Rhizoma Fagopyri Dibotryis, Herba Hyperici Japonici, Herba Patriniae, add the water of 10 times of medical material weight, extract 2 times, each 2 hours, filter, when filtrate decompression is concentrated into 60 ℃, measuring relative density is 1.10～1.15, let cool, add ethanol to reaching 60%, hold over night containing alcohol amount, filter, decompression filtrate recycling ethanol, to without alcohol taste, adds above-mentioned distillate, add sodium benzoate appropriate, mix, fill, to obtain final product.
Pharmaceutical composition of the present invention is mainly used in antiviral, anti-avian influenza.By medicine of the present invention Experiment on Function to bird flu virus on MDCK and Embryo Gallus domesticus, show that medicine of the present invention not only has direct deactivation to bird flu virus, can also enter the antiviral effect of performance in cell.
There is the general character such as high hot, hemorrhage, diarrhoea, drink appetite depression or useless exhausted, hypoimmunity for morbidity chicken in medicine of the present invention, selects the multi-medicaments such as Herba Hyperici perforati, Rhizoma Atractylodis, Fructus Tsaoko, Rhizoma Fagopyri Dibotryis, plays antiviral and prevent the effect of secondary infection.The present invention is by the method for the treatment of of heat-clearing and toxic substances removing, and satisfied curative effect has been received in the prevention to bird flu in clinical trial and treatment.Processing technology of the present invention is simple, and cost is low.
The specific embodiment
With specific embodiment, pharmaceutical composition prepared by the present invention is described again below, following examples are only for illustrating the present invention, and the present invention is not limited to this.
Embodiment 1
Prescription: Herba Hyperici perforati 200g Rhizoma Atractylodis 200g Fructus Tsaoko 150g Rhizoma Fagopyri Dibotryis 150g Herba Hyperici Japonici 100g Herba Patriniae 100g Rhizoma Et Radix Notopterygii 100g
Method for making: get Rhizoma Atractylodis, Fructus Tsaoko, Rhizoma Et Radix Notopterygii, add 3150ml water, distillation extraction, and receive 1350ml distillate, for subsequent use; In medicinal residues, add Herba Hyperici perforati, Rhizoma Fagopyri Dibotryis, Herba Hyperici Japonici, Herba Patriniae, add 10L water, extract 2 times, each 2 hours, filter, when filtrate decompression is concentrated into 60 ℃, measuring relative density is 1.10～1.15, let cool, add ethanol to reaching 60%, hold over night containing alcohol amount, filter, decompression filtrate recycling ethanol, to without alcohol taste, adds above-mentioned distillate, add sodium benzoate 10g, mix, fill, 10ml/ props up, and flowing steam sterilization obtains oral liquid.(100 of theoretical yields, 95 of actual oral liquid finished products, yield rate 95%)
Embodiment 2:
Prescription: Herba Hyperici perforati 1800g Rhizoma Atractylodis 2200g Fructus Tsaoko 1300g Rhizoma Fagopyri Dibotryis 1700g Herba Hyperici Japonici 1200g Herba Patriniae 800g Rhizoma Et Radix Notopterygii 800g
Method for making: get Rhizoma Atractylodis, Fructus Tsaoko, Rhizoma Et Radix Notopterygii, add 25.8L water, distillation extraction, and receive 12.9L distillate, for subsequent use; In medicinal residues, add Herba Hyperici perforati, Rhizoma Fagopyri Dibotryis, Herba Hyperici Japonici, Herba Patriniae, add 78.4L water, extract 2 times, each 2 hours, filter, when filtrate decompression is concentrated into 60 ℃, measuring relative density is 1.10～1.15, let cool, add ethanol to reaching 60%, hold over night containing alcohol amount, filter, decompression filtrate recycling ethanol, to without alcohol taste, adds above-mentioned distillate, add sodium benzoate 100g, mix, fill, 10ml/ props up, and flowing steam sterilization obtains oral liquid.(1000 of theoretical yields, 978 of actual oral liquid finished products, oral liquid yield rate 97.8%)
Embodiment 3:
Prescription: Herba Hyperici perforati 22kg Rhizoma Atractylodis 18kg Fructus Tsaoko 17kg Rhizoma Fagopyri Dibotryis 13kg Herba Hyperici Japonici 8kg Herba Patriniae 12kg Rhizoma Et Radix Notopterygii 12kg
Method for making: get Rhizoma Atractylodis, Fructus Tsaoko, Rhizoma Et Radix Notopterygii, add 376L water, distillation extraction, and receive 141L distillate, for subsequent use; In medicinal residues, add Herba Hyperici perforati, Rhizoma Fagopyri Dibotryis, Herba Hyperici Japonici, Herba Patriniae, add 1020L water, extract 2 times, each 2 hours, filter, when filtrate decompression is concentrated into 60 ℃, measuring relative density is 1.10～1.15, let cool, add ethanol to reaching 60%, hold over night containing alcohol amount, filter, decompression filtrate recycling ethanol, to without alcohol taste, adds above-mentioned distillate, add sodium benzoate 1kg, mix, fill, 500ml/ bottle, flowing steam sterilization, obtains mixture.(200 bottles of theoretical yields, 196 bottles of actual mixture finished products, mixture yield rate 98%)
Embodiment 4:
Prescription: Herba Hyperici perforati 4kg Rhizoma Atractylodis 4kg Fructus Tsaoko 3kg Rhizoma Fagopyri Dibotryis 3kg Herba Hyperici Japonici 2kg Herba Patriniae 2kg Rhizoma Et Radix Notopterygii 2kg
Method for making: get Rhizoma Atractylodis, Fructus Tsaoko, Rhizoma Et Radix Notopterygii, add 54L water, distillation extraction, and receive 27L distillate, for subsequent use; In medicinal residues, add Herba Hyperici perforati, Rhizoma Fagopyri Dibotryis, Herba Hyperici Japonici, Herba Patriniae, add 200L water, extract 2 times, each 2 hours, filter, when filtrate decompression is concentrated into 60 ℃, measuring relative density is 1.10～1.15, let cool, add ethanol to reaching 60%, hold over night containing alcohol amount, filter, decompression filtrate recycling ethanol, to without alcohol taste, adds above-mentioned distillate, add sodium benzoate 200g, mix, fill, 250ml/ bottle, flowing steam sterilization, obtains mixture.(77 bottles of theoretical yields, 74 bottles of actual mixture finished products, mixture yield rate 96%)
Above-described embodiment shows, the preparation that pharmaceutical composition of the present invention is made, and its yield rate is all higher than 95%.The prescription that the present composition is described is reasonable, and technique is reasonable, feasible, possesses the prospect of practical application.
Embodiment 5:
There are 4800 of laying hens (sea is blue brown) in chicken farm, gives chemoprophylaxis first 20 days of concurrent phase of bird flu.
Scheme one: 1-3 hen house is totally 3000 laying hens, gives the made mixture medication of embodiment 4 in the present invention, scheme: mixed drink, the 100L dilution that adds water of every 250ml medicine, successive administration 4 days.
Two: 4, No. 5 hen houses of scheme totally 1800 laying hens, give Huanglian Jiedusan (Xin Da bio tech ltd, Shanghai), scheme: mixed drink, warm water was soaked after 20 minutes, the every 250ml of the medicinal liquid 100L dilution that adds water, successive administration 4 days.
As a result, give the laying hen of medicine of the present invention, occur without bird flu in the concurrent phase of bird flu, prevention rate reaches 100%, successfully plays preventive effect.Give the laying hen of Huanglian Jiedusan, within the concurrent phase of bird flu, find that there is that part laying hen spirit is depressed, cough, swelling around the eyes shed tears, draw the thin feces of Lycoperdon polymorphum Vitt, produce the clinical symptoms such as soft-shelled egg, immediately this disease chicken is isolated for treatment, totally 286, remain the chicken that do not fall ill and give the measures such as ventilation, sterilization, do not have again similar symptom to occur.Matched group prevention success rate is 84%.
Embodiment 6:
There are 13 of ducks in certain peasant household, infects bird flu, heating, rare aquiform stool, anorexia.Get the made oral liquid treatment of embodiment 2, scheme: all duck isolation, gavage, only, three times on the one, administration 4 days, has 11 recoveries from illness to a 2ml/, and dead after another two isolation, effective percentage reaches 86%.
Embodiment 7:
3500 left and right of certain chicken farm raising broiler, when 35 days ages of chicken, infect bird flu, composition medicine drug treatment in using embodiments of the invention 3, usage: mixed drink, the add water 100L dilution of every 500ml medicine, medication 3 days, and the measure such as auxiliary cleaning, cleaning, sterilization, isolation, 92.8% sick chicken is cured as a result.
Show that through multiple healing cases pharmaceutical composition prepared by the present invention can effectively preventing bird flu, rather than because the case that the difference on individuality or Therapeutic Method causes.Medicine of the present invention has good application and popularization value.
Claims (6)
1. a pharmaceutical composition of preventing and treating bird flu, is characterized in that, its crude drug and weight portion are as follows:
180～220 parts of Herba Hyperici perforatis, 180～220 parts of Rhizoma Atractylodis, 130～170 parts of Fructus Tsaokos, 130～170 parts of Rhizoma Fagopyri Dibotryiss, 80～120 parts of Herba Hyperici Japonici, 80～120 parts of Herba Patriniae, 80～120 parts of Rhizoma Et Radix Notopterygiis.
2. pharmaceutical composition as claimed in claim 1, is characterized in that, its crude drug and weight portion are as follows:
200 parts of Herba Hyperici perforatis, 200 parts of Rhizoma Atractylodis, 150 parts of Fructus Tsaokos, 150 parts of Rhizoma Fagopyri Dibotryiss, 100 parts of Herba Hyperici Japonici, 100 parts of Herba Patriniae, 100 parts of Rhizoma Et Radix Notopterygiis.
3. the preparation method of a kind of pharmaceutical composition of preventing and treating bird flu as claimed in claim 1 or 2, is characterized in that: gets Rhizoma Atractylodis, Fructus Tsaoko, Rhizoma Et Radix Notopterygii, adds the water of 6～8 times of amounts of medical material weight, and distillation extraction, and receive the distillate of 3 times of amounts of medical material weight, for subsequent use; In medicinal residues, add Herba Hyperici perforati, Rhizoma Fagopyri Dibotryis, Herba Hyperici Japonici, Herba Patriniae, add the water of 8～12 times of medical material weight, extract 1～3 time, each 2 hours, filter, when filtrate decompression is concentrated into 60 ℃, measuring relative density is 1.10～1.15, let cool, add ethanol to reaching 50～70% containing alcohol amount, leave standstill, filter, decompression filtrate recycling ethanol, adds above-mentioned distillate, adds sodium benzoate appropriate, mix, to obtain final product.
4. the preparation method of a kind of pharmaceutical composition of preventing and treating bird flu as claimed in claim 3, is characterized in that: gets Rhizoma Atractylodis, Fructus Tsaoko, Rhizoma Et Radix Notopterygii, adds the water of 7 times of amounts of medical material weight, and distillation extraction, and receive the distillate of 3 times of amounts of medical material weight, for subsequent use; In medicinal residues, add Herba Hyperici perforati, Rhizoma Fagopyri Dibotryis, Herba Hyperici Japonici, Herba Patriniae, add the water of 10 times of medical material weight, extract 2 times, each 2 hours, filter, when filtrate decompression is concentrated into 60 ℃, measuring relative density is 1.10～1.15, let cool, add ethanol to reaching 60% containing alcohol amount, leave standstill, filter, decompression filtrate recycling ethanol, adds above-mentioned distillate, add sodium benzoate appropriate, mix, fill, to obtain final product.
5. the preparation method of a kind of pharmaceutical composition of preventing and treating bird flu as described in claim 3 or 4, is characterized in that: compositions is made into any in mixture or oral liquid.
6. the application of the pharmaceutical composition described in claim 1 or 2 in the medicine for the preparation of anti-avian influenza.
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| CN103212015B true CN103212015B (en) | 2014-06-04 |
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| CN103875985A (en) * | 2014-04-02 | 2014-06-25 | 陈迎霞 | Poultry feed with functions of clearing heat, removing toxicity and preventing influenza, and preparation method of feed |
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