CN103704514A - Feed for treating porcine contagious pleuropneumonia and preparation method of feed - Google Patents
Feed for treating porcine contagious pleuropneumonia and preparation method of feed Download PDFInfo
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Abstract
The invention discloses a feed for treating porcine contagious pleuropneumonia and a preparation method of the feed. The feed comprises the following raw materials: rice, pearl barley, wheat bran, lily powder, whey powder, plasma protein powder and medicaments for treating the porcine contagious pleuropneumonia. The feed has the beneficial effects that the feed contains the medicaments for treating the porcine contagious pleuropneumonia, and the medicaments have therapeutic principles of clearing away heat, purging pathogenic fire, resisting bacteria, diminishing inflammation, nourishing lungs and yin and relieving cough and asthma, are interacted with the other raw materials to play a combined role and have the advantages of good treat effect, quick effectiveness and low toxic and side effects and cost when being used for treating the porcine contagious pleuropneumonia.
Description
Technical field
The present invention relates to pig feed technical field, particularly a kind of feed that is used for the treatment of porcine contagious pleuropneumonia and preparation method thereof.
Background technology
Pig transmissible pleurisy is a kind of respiratory infectious disease of the pig that caused by pleurisy Actinobacillus, take pneumonia and pleurisy as characteristic pathology.This disease can cause the height expiratory dyspnea of pig, acute sepsis occurs and die by visitation of God; After infecting, the growing-finishing pigs of survival is slow, and average daily gain and the price of deed decline, and resistance toly crosses boar and because carrying disease germs, often become the potential infection sources.Pathogen is Actinobacillus pleuropneumoniae, is club shape, shaft-like, trichobacteria; Showing as polymorphy, do not move, is Gram-positive amphimicrobian; Optimum growth temperature is 37 ℃, 25 ~ 43 ℃ of growth scope; Resistance is not strong, and conventional disinfectant and lower killing, have certain resistance to low temperature, can survive 7 ~ 10 days at 5 ℃.Germ is mainly present in disease porcine respiratory.Winter and early spring are multiple season, and the pig of all ages and classes, sex is susceptible all, and with the susceptible of 6 weeks ~ 3 monthly age piglet, and 4 ~ 5 monthly age pig Mortalities are more.The factor of height that affects the incidence of disease and the death rate is a lot, as abrupt change of climate, and improper ventilation, the flip-flop of feeding environment, intensive raising and long-distance transport etc.With the improvement of feeding and management condition and environmental condition, reduce to some extent.
Porcine contagious pleuropneumonia incubation period is 1 ~ 7 day, wherein the most acutely shows as with acute pig, and sick pig sudden onset, hyperthermia to 41.5 ~ 42 ℃, do not eat food, and spirit is depressed, is short of breath, sometimes laxativeness; Later stage expiratory dyspnea, presents and dehisces to loll, and dog sitting posture flows out foam sample secretion from mouth and nose, is sometimes with color, palpitating speed, and as mouth, nose, ear, four limbs skin are mulberry, often dead in 2 days, the not aobvious symptom of indivedual pigs is dead.Some pig may transfer to subacute and chronic, 39 ~ 40 ℃ of sick temperature of pig body, and anorexia or absolutely useless, intermittent cough, symptom progressively relaxes.But pig some chronic type or healing or subclinical infection, when the environment changes such as other pathogenic infections (as Pasteurella or mycoplasma etc.) or transportation, all may make symptom increase the weight of or transfer to acute.
The prevention of this disease is mainly to do pig house environment health well, prevents by chronic, the recessive pig of outer introducing and the pig that carries disease germs, once import health pig into, is difficult to remove.As introduced a fine variety, should isolate and carry out Serological testing, confirm as negative pig and just can introduce.
General choice drug is penicillin, chloramphenicol and SMZ-SD-TMP methyl isoxazole (radonil), or should coordinate the sodium acid carbonate (sodium bicarbonate) of equivalent during radonil for oral administration.Also can select long-acting terramycin, obtain meter Xian etc.The shortcoming of Western medicine is that side effect is relatively large, is not suitable for long-term taking, and be also not suitable for used as health medicine more, and some medicines easily produce drug resistance or the resistance to the action of a drug.And Chinese Chinese traditional herbs is in the fat metabolism of regulation and control Swine, prevent and treat porcine contagious pleuropneumonia aspect and there is advantageous advantage, can be for control porcine contagious pleuropneumonia.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of feed that is used for the treatment of porcine contagious pleuropneumonia, and feed contains the medicine that is used for the treatment of porcine contagious pleuropneumonia, and medicine has advantages of that good effect, instant effect, toxic and side effect are little, with low cost.
In order to realize foregoing invention object, the invention provides a kind of feed that is used for the treatment of porcine contagious pleuropneumonia, it is characterized in that, described feed comprises following raw material: rice, the seed of Job's tears, wheat bran, lily root flour, whey powder, SDPP and be used for the treatment of the medicine of porcine contagious pleuropneumonia.
Described feed is comprised of the raw material of following parts by weight: rice 50-70 weight portion, seed of Job's tears 30-50 weight portion, wheat bran 30-50 weight portion, lily root flour 10-20 weight portion, whey powder 15-25 weight portion, SDPP 10-15 weight portion and be used for the treatment of the medicine 8-12 weight portion of porcine contagious pleuropneumonia.
Described feed is preferably comprised of the raw material of following parts by weight: rice 55-65 weight portion, seed of Job's tears 35-45 weight portion, wheat bran 35-45 weight portion, lily root flour 13-18 weight portion, whey powder 18-23 weight portion, SDPP 12-14 weight portion and be used for the treatment of the medicine 9-11 weight portion of porcine contagious pleuropneumonia.
Described medicine comprises following raw medicinal material: the bark of official magnolia, cynanchum paniculatum, OVIDUCTUS RANNAE, lepidium seed, the root of large-flowered skullcap, the coptis, sensitive plant, elongated swertia herb, rhodiola root, caulis bambusae in taenian, meter Lu, reed rhizome, radish seed, Japanese Raspberry Root, spinyleaf pricklyash root, Smallfruit Fig Aerial Root, stephanotis, Hui Bao, Mao Li and lanceleaf thermopsis herb.
Described medicine is preferably comprised of the raw medicinal material of following parts by weight: bark of official magnolia 20-30 weight portion, cynanchum paniculatum 15-25 weight portion, OVIDUCTUS RANNAE 10-20 weight portion, lepidium seed 10-20 weight portion, root of large-flowered skullcap 20-30 weight portion, coptis 20-30 weight portion, sensitive plant 20-30 weight portion, elongated swertia herb 10-30 weight portion, rhodiola root 10-20 weight portion, caulis bambusae in taenian 10-30 weight portion, rice reveals 20-30 weight portion, reed rhizome 10-20 weight portion, radish seed 10-30 weight portion, Japanese Raspberry Root 10-20 weight portion, spinyleaf pricklyash root 10-20 weight portion, Smallfruit Fig Aerial Root 10-20 weight portion, stephanotis 10-20 weight portion, ash bag 10-20 weight portion, Mao Li 20-30 weight portion and lanceleaf thermopsis herb 5-10 weight portion.
Described medicine is preferably comprised of the raw medicinal material of following parts by weight: bark of official magnolia 23-27 weight portion, cynanchum paniculatum 17-23 weight portion, OVIDUCTUS RANNAE 13-17 weight portion, lepidium seed 12-18 weight portion, root of large-flowered skullcap 23-27 weight portion, coptis 22-28 weight portion, sensitive plant 23-28 weight portion, elongated swertia herb 15-20 weight portion, rhodiola root 13-18 weight portion, caulis bambusae in taenian 14-23 weight portion, rice reveals 23-28 weight portion, reed rhizome 13-17 weight portion, radish seed 15-26 weight portion, Japanese Raspberry Root 13-17 weight portion, spinyleaf pricklyash root 13-17 weight portion, Smallfruit Fig Aerial Root 12-18 weight portion, stephanotis 13-18 weight portion, ash bag 13-15 weight portion, Mao Li 23-29 weight portion and lanceleaf thermopsis herb 5-8 weight portion.
Described medicine is preferably comprised of the raw medicinal material of following parts by weight: the bark of official magnolia 25 weight portions, cynanchum paniculatum 19 weight portions, OVIDUCTUS RANNAE 15 weight portions, lepidium seed 15 weight portions, the root of large-flowered skullcap 25 weight portions, the coptis 26 weight portions, sensitive plant 26 weight portions, elongated swertia herb 17 weight portions, rhodiola root 15 weight portions, caulis bambusae in taenian 18 weight portions, rice reveals 25 weight portions, reed rhizome 15 weight portions, radish seed 21 weight portions, Japanese Raspberry Root 15 weight portions, spinyleaf pricklyash root 15 weight portions, Smallfruit Fig Aerial Root 15 weight portions, stephanotis 16 weight portions, ash bag 14 weight portions, Mao Li 26 weight portions and lanceleaf thermopsis herb 6 weight portions.
Described medicine also comprises: Chinese yam, pawpaw, Divine Comedy, auricularia auriculajudae and hawthorn.
Described medicine is preferably comprised of the raw medicinal material of following parts by weight: bark of official magnolia 20-30 weight portion, cynanchum paniculatum 15-25 weight portion, OVIDUCTUS RANNAE 10-20 weight portion, lepidium seed 10-20 weight portion, root of large-flowered skullcap 20-30 weight portion, coptis 20-30 weight portion, sensitive plant 20-30 weight portion, elongated swertia herb 10-30 weight portion, rhodiola root 10-20 weight portion, caulis bambusae in taenian 10-30 weight portion, rice reveals 20-30 weight portion, reed rhizome 10-20 weight portion, radish seed 10-30 weight portion, Japanese Raspberry Root 10-20 weight portion, spinyleaf pricklyash root 10-20 weight portion, Smallfruit Fig Aerial Root 10-20 weight portion, stephanotis 10-20 weight portion, ash bag 10-20 weight portion, Mao Li 20-30 weight portion, lanceleaf thermopsis herb 5-10 weight portion, Chinese yam 10-20 weight portion, pawpaw 10-20 weight portion, Divine Comedy 10-20 weight portion, auricularia auriculajudae 10-20 weight portion and hawthorn 10-20 weight portion.
Described medicine is preferably comprised of the raw medicinal material of following parts by weight: bark of official magnolia 23-27 weight portion, cynanchum paniculatum 17-23 weight portion, OVIDUCTUS RANNAE 13-17 weight portion, lepidium seed 12-18 weight portion, root of large-flowered skullcap 23-27 weight portion, coptis 22-28 weight portion, sensitive plant 23-28 weight portion, elongated swertia herb 15-20 weight portion, rhodiola root 13-18 weight portion, caulis bambusae in taenian 14-23 weight portion, rice reveals 23-28 weight portion, reed rhizome 13-17 weight portion, radish seed 15-26 weight portion, Japanese Raspberry Root 13-17 weight portion, spinyleaf pricklyash root 13-17 weight portion, Smallfruit Fig Aerial Root 12-18 weight portion, stephanotis 13-18 weight portion, ash bag 13-15 weight portion, Mao Li 23-29 weight portion, lanceleaf thermopsis herb 5-8 weight portion, Chinese yam 15-20 weight portion, pawpaw 15-20 weight portion, Divine Comedy 13-16 weight portion, auricularia auriculajudae 15-20 weight portion and hawthorn 12-17 weight portion.
Described medicine is preferably comprised of the raw medicinal material of following parts by weight: the bark of official magnolia 25 weight portions, cynanchum paniculatum 20 weight portions, OVIDUCTUS RANNAE 15 weight portions, lepidium seed 15 weight portions, the root of large-flowered skullcap 25 weight portions, the coptis 25 weight portions, sensitive plant 25 weight portions, elongated swertia herb 17 weight portions, rhodiola root 16 weight portions, caulis bambusae in taenian 18 weight portions, rice reveals 25 weight portions, reed rhizome 15 weight portions, radish seed 21 weight portions, Japanese Raspberry Root 15 weight portions, spinyleaf pricklyash root 15 weight portions, Smallfruit Fig Aerial Root 15 weight portions, stephanotis 16 weight portions, ash bag 14 weight portions, Mao Li 25 weight portions, lanceleaf thermopsis herb 6 weight portions, Chinese yam 17 weight portions, pawpaw 17 weight portions, Divine Comedy 14 weight portions, auricularia auriculajudae 17 weight portions and hawthorn 15 weight portions.
The preparation method of described medicine comprises the following steps:
A, cross 120 order dusting covers after described raw medicinal material is put into pulverizer and pulverized, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%～40%, collects by the raw material fine powder of 120 mesh sieves, and particle remaining after sieving is standby;
B, particle remaining after sieving is put into the ethanol heating and refluxing extraction twice that the determining alcohol of 5～7 times of amounts is 85%, each 1～2 hour, extracted twice liquid is merged standing, obtain extract 1, the dregs of a decoction are standby;
C, the dregs of a decoction that in step b, alcohol extract is crossed are added to 5～7 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, No. 2 extracts are merged standing, obtain extract 2;
D, extract 1 and extract 2 merged, filter 1.38 filtrate when reduced pressure concentration relative density is 50 ℃～60 ℃, reclaim ethanol, gained filtrate is adjusted to proportion to 1.06, pass into spray dryer and spray dryly, the compressed air pressure of mistake spray dryer shower nozzle is 4kg/m
2, hothouse hot stream temperature is 100 ℃, obtains raw material medicinal powder; The medicine that the raw material fine powder obtaining after step a is sieved mixes with raw material medicinal powder.
In order better to realize foregoing invention object, the present invention also provides a kind of preparation method who is used for the treatment of the feed of porcine contagious pleuropneumonia, and described preparation method comprises the following steps:
The first step, take by ratio of weight and the number of copies rice, the seed of Job's tears, wheat bran, lily root flour, whey powder, SDPP and be used for the treatment of the medicine of porcine contagious pleuropneumonia, dropping into pulverizer pulverizes, grinding particle size is 200-300 order, by the mixture after pulverizing and input mixer, mix the uniformity≤5% of mixing;
Second step, pours into after mixing in the granulating disc that is placed in heeling condition and carries out granulation, and the rotating speed of granulating disc is 50 revs/min, and preparation time is 15 minutes, is prepared into diameter and is the spherical particle feed of 1 millimeter;
The 3rd step, the spherical particle feed that second step is obtained, spreads in having on the mesh-belt drier of the portable stainless steel guipure of multilayer, heat drying 15 minutes, the import air temperature of heating is 140 ℃, outlet air temperature is 70 ℃, obtains dry feed granules.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: feed of the present invention contains and is used for the treatment of the pleuritic medicine of pig transmissible, this medicine take clearing heat-fire, anti-inflammation, support lung enriching yin, relieving cough and asthma be principle of reatment, cooperatively interact with other raw materials, acting in conjunction, treatment porcine contagious pleuropneumonia has advantages of that good effect, instant effect, toxic and side effect are little, with low cost.
The specific embodiment
Pig transmissible pleurisy is a kind of respiratory infectious disease of the pig that caused by pleurisy Actinobacillus, take pneumonia and pleurisy as characteristic pathology.Present pneumonia and pleuritic characteristic symptom and pathology, acute person's death rate is high, the upper ability mistake of chronic person.The pig of various ages, sex has neurological susceptibility, and the incidence of disease and death have very big-difference.Germ is mainly present in disease porcine respiratory, often by air droplet transmission, and the easiest contact transmission under the condition of the intensive feed of jumpbogroup, boar plays an important role in propagating link.Propagation between swinery is mainly by introducing carry disease germs pig or chronic infection pig.Acute case body temperature can be increased to more than 42 ℃, and expiratory dyspnea, rapid is often stood or is dog and sits and be reluctant and sleeping ground, dehisce to loll, be in anguish, as treatment, often death by suffocation in 24-48 hour not in time.Also before having the most acute person dead, can not see symptom.If symptom comparatively relaxes while starting, ability is crossed more than 4 days, and symptom progressively disappears, often can be healthy voluntarily, but the course of disease is longer.After a lot of pigs infect, clinical symptom is lighter, is chronic process.The case of acute death, lung is aubergine, and tangent plane is like liver, and interstitial is full of color glue sample liquid, 24 hours above persons of the course of disease, pneumonia district often occurs that fiber disposition thing invests surface, and has yellow diffusate; The case that the course of disease is longer, visible strong pneumonia district, there is the adhesive attachment of connective tissue on surface, and pneumonia focus becomes scleroma or necrotic lesion, with wall of the chest adhesion.
The present invention take clearing heat-fire, anti-inflammation, support lung enriching yin, relieving cough and asthma be principle of reatment, the feed providing contains the medicine that is used for the treatment of porcine contagious pleuropneumonia, comprises following raw medicinal material: the bark of official magnolia, cynanchum paniculatum, OVIDUCTUS RANNAE, lepidium seed, the root of large-flowered skullcap, the coptis, sensitive plant, elongated swertia herb, rhodiola root, caulis bambusae in taenian, meter Lu, reed rhizome, radish seed, Japanese Raspberry Root, spinyleaf pricklyash root, Smallfruit Fig Aerial Root, stephanotis, Hui Bao, Mao Li and lanceleaf thermopsis herb.
Wherein, the pharmacological property of each raw medicinal material is:
The bark of official magnolia: the bark of official magnolia and volatile oil bitter thereof can stimulate the sense of taste, reflexively causes the quickening of saliva, gastric secretion, gastrointestinal peristalsis, and has stomach invigorating digestion-aid effect; Resisting pathogenic microbes acting body experiment showed, that bark of official magnolia decoction all has antibacterial action to gram negative bacillis such as the gram positive bacterias such as staphylococcus, hemolytic streptococcus, pneumococcus, Bordetella pertussis and bacillus anthracis, shigella dysenteriae, typhoid bacillus, paratyphosum Bacterium, comma bacillus, Escherichia coli, proteus, hay bacilluses outward; Decoction has inhibitory action to toad isolated heart. magnocurarine drug administration by injection, when lower than muscle relaxant amount, there is obvious hypotensive effect, this effect can not be by antihistamine institute antagonism, the step-down of Bolos intravenous administration is held time and is about 10～15 minutes, and the step-down of intramuscular administration is held time and can be reached more than 1 hour.The tincture hydrotrope of Flos Magnoliae Officinalis all has hypotensive effect to anesthetized cat, the quiet note of rabbit or intramuscular injection, and can make heart rate accelerate.
Cynanchum paniculatum: cool in nature; Taste is pungent.Return lung channel.Function cures mainly: heat-clearing is loose strongly fragrant.Main chronic bronchitis.
OVIDUCTUS RANNAE: sweet, salty, flat.Return lung, kidney channel.Function cures mainly: tonifying kidney and benefiting sperm, Yin nourishing and lung moistening.Weak for the deficiency of Yin, spiritlessness and weakness, palpitation and insomnia, night sweat is more than, the consumptive disease hemoptysis of coughing.
Lepidium seed: pungent, bitter, Great Cold.Return lung, urinary bladder channel.Function cures mainly: removing heat from lung and relieving asthma, line water detumescence.For sputum, stop up lung, dyspnea and cough with excessive sputum, fullness in chest and hypochondrium, must not put down sleepingly, and chest ascites is swollen, difficult urination; Cor pulmonale oedema.
The root of large-flowered skullcap: have heat-clearing and damp-drying drug, cool blood is antiabortive, detoxicating functions.Cure mainly the diseases such as warm heat disease, the infection of the upper respiratory tract, cough with lung heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, hot eyes, fetal irritability, hypertension, the swollen furuncle sore of carbuncle.The clinical practice of the root of large-flowered skullcap is antibacterial not worse than the coptis, and does not develop immunity to drugs.We are used in fungal culture miscellaneous bacteria and infect special severity by the strong feature of broad-spectrum antibacterial action, fine by root of large-flowered skullcap extract effect.< < Bencao Jingshu > >: the root of large-flowered skullcap, its property is respectful clearly, so evil removing: so bitter eliminating dampness; So cold sensation of the genitalia victory heat, therefore main all heat.All hot persons, heat symptoms caused by an exopathgen with all over heat also, jaundice, intestines be out-of-the-way, let out dysentery, the disease of all damp and hot victory also, is analysed it, all diseases are from recover.Bitter cold can be except damp and hot, thus small intestine profit and water from by, source is clearly flowed also clean.The blood person of closing, real heat is at blood system, and instant heating human blood chamber, makes us obstructed through closing, damp and hot solution, Ying Qi is clearly and voluntarily also.Dislike sore subcutaneous ulcer erosion person, blood-head is stayed knot, and is that the swollen stain of carbuncle is also rotten: fiery ulcer person, internal heat blood trouble also, cool blood heat extraction, self-healing also.
The coptis: bitter, cold in nature, enter the heart, lung, courage, stomach, large intestine channel, there is heat-clearing and damp-drying drug, purging intense heat and detonicating, the effect of cooling blood for improving eyesight, cure mainly damp and hot ruffian full, vomiting acid regurgitation, rush down dysentery, jaundice, unconsciousness due to high fever, heart-fire hyperactivity, dysphoria and insomnia, blood-head is told nosebleed, hot eyes, toothache, quench one's thirst, the carbuncle furunculosis that swells, eczema, wet sore, the duct card such as suppurate, the coptis is light broad spectrum antiviral drug thing, can effectively reduce the drug resistance of salmonella, to staphylococcus aureus, blood dissolubility streptococcus, streptococcus pneumonia, meningococcus, shigella dysenteriaes etc. have stronger bacteriostasis, < < Amplification on Materia Medica > >: the multiplex dysentery of controlling of moderns, lid is held with the dry justice of hardship.Lower valgar but see that intestines void is oozed and let out, micro-seemingly have a bloody stool, uses it, only more do not know.Ignore again fever and chills how many, but take most agent as degree, by being that to cause danger tired more.If gas is real just sick, hot many bloody flux, just stopping of clothes still needn't be use up agent also.Or empty and cold, must not take.It is remaining if < < is through > >.
Sensitive plant: sweet, puckery, cool.Slightly poisonous.Function cures mainly: reducing fever and causing diuresis, preventing phlegm from forming and stopping coughing, ataralgesia.For flu, infantile hyperpyrexia, acute conjunctivitis, bronchitis, gastritis, enteritis, stone in urinary system, malaria, neurasthenia; Treating swelling and pain by traumatic injury is controlled in external application, sore swollen toxin.
Elongated swertia herb: hardship, cool.Clearing heat and detoxicating; Dampness removing.Main jaundice with damp-heat pathogen; Cough with lung heat; Abscess of throat; Toothache; Dysentery; Urinary tract infections; Pyogenic osteomyelitis; Conjunctivitis; Adnexitis; Pelvic infecton; Herpes zoster; Mange sore.
Rhodiola root: sweet, puckery, cold.Function cures mainly: removing heat from the lung to relieve cough, hemostasis, only band.For cough with lung heat, spitting of blood, leukorrhea; Traumatic injury is controlled in external application, burn and scald.
Caulis bambusae in taenian: sweet, be slightly cold.Attach to the lung and stomach meridians.Function cures mainly: clearing heat and eliminating phlegm, relieves restlessness and prevents vomiting.For phlegm-heat cough, courage fire is held phlegm under the arm, dysphoria with smothery sensation vomiting, and eye, apoplexy phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pernicious vomiting, fetal irritability are lost in palpitation with fear.
Meter Lu: sweet; Light; Flat.Function cures mainly: strengthening the spleen and tonifying the lung; Stimulating appetite.Main insufficiency of the spleen food is few; Large loose stool is thin; Chronic cough of deficiency lung
Reed rhizome: attach to the lung and stomach meridians.Function cures mainly: clearing heat and promoting fluid, relieving restlessness, preventing or arresting vomiting, diuresis.For pyreticosis polydipsia, the stomach energy sound of vomiting of vomitting, cough with lung heat, lung carbuncle pyemesis, the puckery pain of heat pouring.1. the contained Coixol of this product has inhibitory action to skeletal muscle, can suppress the caused contractile response of electro photoluminescence of frog neuromuscular sample and the picked-up of the oxygen of diaphragm in rats and anaerobic glycolysis, and can suppress the reaction of actin-adenosine triphosphate system, also has more weak central inhibitory action, show as rat and mouse all had to sedation, and can with caffeine phase antagonism.On the electroencephalogram of rabbit, occur that wave amplitude increases, frequency reduces, and shows the function of central nervous system is had to inhibition phenomenon.In rat tails electro photoluminescence test, there is analgesic activity, intensity is similar to aminopyrine.Having refrigeration function, the refining complex polysaccharide class to TTG(Pseu-domonas fluorescens thalline) refrigeration function of heat pyrexia is better, and the heating that dinitrophenol dinitrophenolate is caused is without very effect.Polysynaptic reflex (cat nervus peronaeus-specimen-gastrocnemius muscle) is had to of short duration inhibitory action.Intravenous injection can cause the of short duration decline of rabbits blood pressure, and hypodermic injection can make blood sugar slightly decline, and Isolated Toad Heart and isolated rabbit intestines are all to inhibitory action, and rabbit ear blood vessel is had no significant effect.Its toxicity is very low, the oral 0.5g/(kg.d of mouse), lmo does not cause abnormal change.2. the contained Tricin of this product has relexation in vitro cavy intestinal tube, when 2 * l0 (5) concentration, can show inhibition isolated rabbit small intestine and shrink.4mg injects rabbit intestinal in place chamber, can make peristaltic contraction slow down.Award Oral Administration in Rats 2mg every day, can make in blood thyroxine show and increase.And have slight antioxidation, can prevent adrenergic oxidation.There is slight estrogen-like action.Still have antitumaous effect, 6 and 12.5mg to the T/C of mouse P388, be 133 and 174%.
Radish seed: property is flat, and taste is pungent, sweet, returns lung, spleen, stomach warp, has the de-swelling of helping digestion, the effect of lowering the adverse-rising QI to resolve phlegm, cures mainly retention of food and drink, abdominal distention, constipation, the stagnant dysentery, phlegm of rushing down is stopped up the card such as breath with cough.
Japanese Raspberry Root: sweet, cool.Enter lung, liver, spleen three warps.Function cures mainly: induces sweat, and heat-clearing, improving eyesight, diuresis.Cure cold, cough, headache, laryngalgia, hot eyes ocular, urine heat is closed, stranguria with turbid discharge, leukorrhea, carbuncle is swollen, furunculosis.
Spinyleaf pricklyash root: pungent, temperature.Return liver; Lung channel.Function cures mainly: expelling wind and clearing away cold, activate blood and relax tendons, and analgesia.Control cough due to wind-cold evil, rheumatic numbness, traumatic injury, traumatism and bleeding, constipation.
Smallfruit Fig Aerial Root: bitterness, flat.Function cures mainly: expelling wind and clearing away heat, promoting blood circulation and detoxication.Control influenza, pertussis, measles without adequate eruption, tonsillitis, eye conjunctivitis, eruptive disease stomachache, treating rheumatic ostealgia, nosebleed epistaxis, blood drenches, traumatic injury.
Stephanotis: hardship, cold.Function cures mainly: clearing heat and detoxicating, and cooling blood and hemostasis, eliminating stasis to subdue swelling.For oxyhepatitis, bacillary dysentery, acute appendicitis, stomachache, internal haemorrhage, traumatic injury, venomous snake bite; Mumps is controlled in external application, lymphnoditis, neurodermatitis.
Ash bag: light; Pungent; Property is put down.Return lung channel.Function cures mainly: clearing heat, relieving sore-throat; Removing toxic substances sore; Hemostasis.。Main acute laryngopharyngitis; Pneumonia; Pulmonary abscess; Nosebleed epistaxis; Traumatism and bleeding.
Mao Li: control pneumonia, pulmonary tuberculosis, erysipelas, sore.
Lanceleaf thermopsis herb: sweet; Tepor.Return lung channel.Function cures mainly: expelling phlegm and arresting coughing; Relax bowel.Main cough asthma due to excessive phlegm; Dry and hard excrement.1. phlegm-dispelling functions: herb preserved material is excited vomiting and respiratory center directly, and stimulate the sensory nerve ending of stomach, reflexive promotion bronchial secretion.With the same use of ipecac, the effect that has eliminating the phlegm and deepen to accelerate to breathe.2. the effect of pair breathing: anagyrine or the similar nicotine of sparteine effect, can reflexive excited breathing.The sparteine 0.02mg/kg extracting from this product in the femoral vein injection of anesthetized cat or 1.5mg/ only, all have strong excited respiration, while palpitating speed, and blood pressure sharply rises, and recovers normally very soon thereafter in company with the disappearance of respiratory stimulant effect.Experiment showed, the excited respiration of the sparteine 0.06mg/kg extracting from this product, be not only greatly better than the antabac of same dosage, and slightly strong compared with the antabac of 5 times (0.3mg/kg).Methylcytisine effect is similar to sparteine, but compared with 10-12 a little less than it doubly.3. other effects: thermopsine has the inhibitory action of medium degree to vegetative ganglia.Sparteine has of short duration blocking effect to vegetative ganglia, reduces adrenal cortex and sino-carotid reactivity, improves uterus muscle tension force.Anagyrine also can suppress neuromere impulse conduction, but, and have curariform action mask.Dried plant has the effect (contact poison) of kill insects, and herb preserved material still can anthelmintic.The liquid extract intravenous injection of leaf can make exaggerated respiration accelerate, and blood pressure raises, and heart rate accelerates.
Medicine of the present invention also comprises: Chinese yam, pawpaw, Divine Comedy, auricularia auriculajudae and hawthorn.
Chinese yam: taste is sweet, property is flat, enters lung, spleen, stomach warp, has tonifying spleen nourishing the stomach, and beneficial lung reinforces the kidney, the effect of nourishing Yin and promoting production of body fluid, be mainly used in weakness of the spleen and the stomach, the symptom such as it is poor that the food of the dysfunction of the spleen in transport is received less, the vexed diarrhoea of gastral cavity.
Pawpaw: acid, temperature.Return liver, the spleen channel.Function cures mainly: flat liver relaxing muscles and tendons, and stomach dampness elimination.For arthritis with fixed pain caused by dampness contraction, the heavy pain of waist knee joint acid, the convulsion of vomiting and diarrhoea, beriberi oedema.
Divine Comedy: for wholemeal and other drug (sweet wormwood, Siberian cocklebur, the buds such as polygonum flaccidum, almond, rde bean) mix the processed goods forming by fermentation.Get Divine Comedy and put in pot, to fry to appearance and be coke black, inner coke yellow, take out, spray the water that disappears, cool, be stir-baked MASSA FERMENTATA MEDICI-NALIS.Divine Comedy forms through fermentation, and the product of all fermentations have the digestant effect of strengthening the spleen and stomach, therefore, for bad, the feeling of stuffiness in chest abdominal distension of the digestion due to diet internal injury, quite has effect.
Auricularia auriculajudae: sweet, flat.Function cures mainly: fills blood, and moistening lung, hemostasis.For Qi and blood deficiency, four limbs are twitched, cough due to deficiency of the lung, and spitting of blood, spits blood, bleeding from five sense organs or subcutaneous tissue, uterine bleeding, high blood pressure, constipation.
Hawthorn: cut into slices and dry, put in pot and use force large burnt brown, the inner yellowish-brown of frying to outside for spending, spraying clear water, taking-up is dried, and is charred FRUCTUS CRATAEGI.There is appetite-stimulating indigestion-relieving, change the effect of stagnant long-pending, the promoting blood circulation to remove blood stasis of disappearing, the promoting the circulation of qi of reducing phlegm, meridian distribution of property and flavor, sour, sweet, slightly warm in nature.Main component is containing chlorogenic acid, caffeic acid, crataegolic acid, neat chrysanthemum tartaric acid, Quercetin, ursolic acid, oleanolic acid, hyperin, epicatechin etc.Oral hawthorn can increase digestive ferment, promotes fatty decomposition and digestion, to because of eat meat or greasy too much due to abdominal fullness and distention, belch, do not feel like eating, stomachache, diarrhoea person, curative effect is especially good.In addition, modern medicines tests shows, hawthorn has the slow and lasting effect reducing blood pressure, and also can reduce cholesterol and triglycerides, atherosclerosis, but also can diastole coronary artery, increase myocardial contractive power, to anti-arrhythmia.Therefore, be conducive to prevent and treat hypertension, high fat of blood, artery sclerosis and coronary heart disease.
Embodiment 1 medicine 1
The embodiment of the present invention 1 provides a kind of medicine that is used for the treatment of porcine contagious pleuropneumonia, raw medicinal material by following parts by weight forms: the bark of official magnolia 25 weight portions, cynanchum paniculatum 19 weight portions, OVIDUCTUS RANNAE 15 weight portions, lepidium seed 15 weight portions, the root of large-flowered skullcap 25 weight portions, the coptis 26 weight portions, sensitive plant 26 weight portions, elongated swertia herb 17 weight portions, rhodiola root 15 weight portions, caulis bambusae in taenian 18 weight portions, rice reveals 25 weight portions, reed rhizome 15 weight portions, radish seed 21 weight portions, Japanese Raspberry Root 15 weight portions, spinyleaf pricklyash root 15 weight portions, Smallfruit Fig Aerial Root 15 weight portions, stephanotis 16 weight portions, ash bag 14 weight portions, Mao Li 26 weight portions and lanceleaf thermopsis herb 6 weight portions
The preparation method of medicine comprises the following steps:
A, cross 120 order dusting covers after described raw medicinal material is put into pulverizer and pulverized, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%, collects by the raw material fine powder of 120 mesh sieves, and particle remaining after sieving is standby;
B, particle remaining after sieving is put into the ethanol heating and refluxing extraction twice that the determining alcohol of 5 times of amounts is 85%, each 1 hour, extracted twice liquid is merged standing, obtain extract 1, the dregs of a decoction are standby;
C, the dregs of a decoction that in step b, alcohol extract is crossed are added to 5 times of water gaging heating and refluxing extraction 2 times, each 1 hour, No. 2 extracts are merged standing, obtain extract 2;
D, extract 1 and extract 2 merged, filter 1.38 filtrate when reduced pressure concentration relative density is 50 ℃, reclaim ethanol, gained filtrate is adjusted to proportion to 1.06, pass into spray dryer and spray dryly, the compressed air pressure of mistake spray dryer shower nozzle is 4kg/m
2, hothouse hot stream temperature is 100 ℃, obtains raw material medicinal powder; The medicine that the raw material fine powder obtaining after step a is sieved mixes with raw material medicinal powder.
Embodiment 2 medicines 2
The embodiment of the present invention provides a kind of medicine that is used for the treatment of porcine contagious pleuropneumonia, raw medicinal material by following parts by weight forms: the bark of official magnolia 25 weight portions, cynanchum paniculatum 20 weight portions, OVIDUCTUS RANNAE 15 weight portions, lepidium seed 15 weight portions, the root of large-flowered skullcap 25 weight portions, the coptis 25 weight portions, sensitive plant 25 weight portions, elongated swertia herb 17 weight portions, rhodiola root 16 weight portions, caulis bambusae in taenian 18 weight portions, rice reveals 25 weight portions, reed rhizome 15 weight portions, radish seed 21 weight portions, Japanese Raspberry Root 15 weight portions, spinyleaf pricklyash root 15 weight portions, Smallfruit Fig Aerial Root 15 weight portions, stephanotis 16 weight portions, ash bag 14 weight portions, Mao Li 25 weight portions, lanceleaf thermopsis herb 6 weight portions, Chinese yam 17 weight portions, pawpaw 17 weight portions, Divine Comedy 14 weight portions, auricularia auriculajudae 17 weight portions and hawthorn 15 weight portions.
The preparation method of medicine comprises the following steps:
A, cross 120 order dusting covers after described raw medicinal material is put into pulverizer and pulverized, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 40%, collects by the raw material fine powder of 120 mesh sieves, and particle remaining after sieving is standby;
B, particle remaining after sieving is put into the ethanol heating and refluxing extraction twice that the determining alcohol of 6 times of amounts is 85%, each 2 hours, extracted twice liquid is merged standing, obtain extract 1, the dregs of a decoction are standby;
C, the dregs of a decoction that in step b, alcohol extract is crossed are added to 6 times of water gaging heating and refluxing extraction 2 times, each 2 hours, No. 2 extracts are merged standing, obtain extract 2;
D, extract 1 and extract 2 merged, filter 1.38 filtrate when reduced pressure concentration relative density is 60 ℃, reclaim ethanol, gained filtrate is adjusted to proportion to 1.06, pass into spray dryer and spray dryly, the compressed air pressure of mistake spray dryer shower nozzle is 4kg/m
2, hothouse hot stream temperature is 100 ℃, obtains raw material medicinal powder; The medicine that the raw material fine powder obtaining after step a is sieved mixes with raw material medicinal powder.
Embodiment 3 feeds
The embodiment of the present invention provides a kind of feed that is used for the treatment of porcine contagious pleuropneumonia, the raw material of following parts by weight, consists of: rice 61 weight portions, the seed of Job's tears 39 weight portions, wheat bran 39 weight portions, lily root flour 16 weight portions, whey powder 21 weight portions, SDPP 13 weight portions and be used for the treatment of medicine 10 weight portions of porcine contagious pleuropneumonia.
Wherein, the medicine 2 that the above-mentioned medicine that is used for the treatment of porcine contagious pleuropneumonia is embodiment 2.
The preparation method of feed comprises the following steps:
The first step, take by ratio of weight and the number of copies rice, the seed of Job's tears, wheat bran, lily root flour, whey powder, SDPP and be used for the treatment of the medicine of porcine contagious pleuropneumonia, dropping into pulverizer pulverizes, grinding particle size is 300 orders, by the mixture after pulverizing and input mixer, mix the uniformity≤5% of mixing;
Second step, pours into after mixing in the granulating disc that is placed in heeling condition and carries out granulation, and the rotating speed of granulating disc is 50 revs/min, and preparation time is 15 minutes, is prepared into diameter and is the spherical particle feed of 1 millimeter;
The 3rd step, the spherical particle feed that second step is obtained, spreads in having on the mesh-belt drier of the portable stainless steel guipure of multilayer, heat drying 15 minutes, the import air temperature of heating is 140 ℃, outlet air temperature is 70 ℃, obtains dry feed granules.
Toxicity test
1, cumulative toxicity test report
Select 20 healthy mices, female, male each 10, the medicine of the embodiment of the present invention 1 of take is object, it is first phase that dosage designs every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD 50,0.50LD50, and the LD 50 female, male mice of this sample is 5000m part/k part BW (five dosage be 500,750,1100,1700,2500m part/k part BW).Within every 5 days, weigh once, adjust dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose, to tested material after 20 days, female, buck all occurs without death condition.The medicine 2 of embodiment 2 of take is object, carries out according to the method described above toxicity test, and result is as identical in embodiment 1.
2, acute toxicity test
40 of application NIH mouse, SPF level, male and female half and half, body weight 16～20g, carries out acute toxicity test.Mouse is divided into two groups at random, and 20 every group, control group and administration group, test front fasting 12 hours; Medicine dissolving prepared by embodiments of the invention 1 is in water, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is that 5ml/kg(is that single-dose dosage is 32.9 crude drugs/kg), control group gives equivalent physiological saline, administration in a day 2 times, delivery time 6 hours, after administration, Continuous Observation is 14 days, and records toxic reaction and the death toll of mouse.Experimental result shows: with control group comparison, after administration, mouse has no notable difference, experiment Continuous Observation 14 days, and mouse overall health of patients, diet, drinking-water, body weight gain are all normal.The medicine LD50>32.9 crude drug/kg of the mouse oral administration gavage embodiment of the present invention 1, every day, maximum dosage-feeding was 65.8g crude drug/kg/ day.The clinical application amount of the embodiment of the present invention 1 medicine 1 is 3g crude drug/day/head, and piglet body weight is in 6kg, and average dosage is 0.5g crude drug/kg/ day.By batheroom scale: the dosis tolerata of the medicine of mouse (average weight take 20g) the oral administration gavage embodiment of the present invention 1 is quantity 131 times.Therefore the acute toxicity of the medicine 1 of the embodiment of the present invention 1 is low, clinical drug safety.The medicine 2 of embodiment 2 of take is object, carries out according to the method described above toxicity test, and result is as identical in embodiment 1.
Clinical testing
(1) animal used as test
The growing and fattening pigs of 253 60kg left and right are found on pig farm, Jinan City, Shandong Province in March, 2012, more than there is hyperthermia to 41 ℃, expiratory dyspnea and rapid, is often dog and sits and do not act as a planted agent, dehisce to loll, time and cough, anorexia or absolutely useless.Due to not treatment in time, there is two pig dead.Cut open after inspection, find that lung is aubergine, tangent plane is like liver, and interstitial is full of color glue sample liquid, and pneumonia district occurs that fiber disposition thing invests surface, and has yellow diffusate.Be diagnosed as the infectious pleuropneumonia of pig, choose 228 ill pigs as experiment pig.
(2) test method
228 ill pigs are divided into four experimental group at random, every group 57, four experimental group are used respectively the medicine 1(embodiment group 1 of the embodiment of the present invention 1), the medicine 2(embodiment group 2 of embodiment 2), feed (embodiment group 3) and the conventional medicament (control group) of embodiment 3 treat.Embodiment group 1 and embodiment group 2 add feed by medicine 1 and medicine 2 according to the percentage by weight of feed 5-15% respectively, according to the feed mode of feeding, feed, and use continuously 3-5 days; Embodiment group 3, according to the feed feed of embodiment 3 of the tradition mode of feeding, is used 3-4 days continuously; Conventional medicament is selected Florfenicol intramuscular injection, and in liquid, crude drug content is 0.5g/ml, and every day twice, each 4-7ml, is used 3-5 days continuously.
(3) criterion of therapeutical effect
Cure: body temperature, breathing and appetite are all recovered normally, without cough symptom;
Effective: body temperature, breathing and appetite are recovered normally substantially, and cough obviously alleviates;
Invalid: symptom does not disappear or sb.'s illness took a turn for the worse even death be judged to invalid.
Wherein, efficient for curing and effective percentage sum.
(4) treatment results
The results are shown in Table 1, from result for the treatment of, adopting medicine of the present invention is more than 89% to the treated effect of porcine contagious pleuropneumonia, higher than control group.
From the data of table 1, can find out: compare with control group, use the embodiment of the present invention 1, the medicine of embodiment 2 and the feed of embodiment 3 treatment porcine contagious pleuropneumonia, have advantages of evident in efficacy, cure rate is high, the most obvious with the effect of the feed of embodiment 3; In long-term observation subsequently, find, the ill pig that embodiment group 1, embodiment group 2 and embodiment group 3 are cured the again incidence of disease is starkly lower than the pig of control group.
Concrete case
Case 1
Pig Lee raiser in August, 2012 find 13 4 week age piglet all appearance in various degree fever to more than 41 ℃, expiratory dyspnea and rapid, often be dog and sit and do not act as a planted agent, dehisce to loll, time and cough, anorexia is even absolutely useless, an existing piglet death by suffocation before treatment, finds that through cuing open inspection dead piglet lung is aubergine, and tangent plane is like liver, interstitial is full of color glue sample liquid, and pneumonia district occurs that fiber disposition thing invests surface.Be diagnosed as porcine contagious pleuropneumonia, use the ill piglet of forage feed of the embodiment of the present invention 3, use continuously 4 days, 12 piglets all recover normal.
Case 2
Shandong plant finds that in March, 2012 expiratory dyspnea and rapid appears in 40 growing and fattening pigs, time and cough, anorexia is even absolutely useless, through blood drawing serum, detect and to be diagnosed as porcine contagious pleuropneumonia, the medicine to adding the embodiment of the present invention 2 of feed gross weight 12% in feed, is used 3 days continuously, 35 growing and fattening pigs all recover normal, other 5 treatments effectively, continue to use 2 days, and 5 ill pigs all recover normal.
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (10)
1. the feed that is used for the treatment of porcine contagious pleuropneumonia, is characterized in that, described feed comprises following raw material: rice, the seed of Job's tears, wheat bran, lily root flour, whey powder, SDPP and be used for the treatment of the medicine of porcine contagious pleuropneumonia.
2. the pleuritic feed of pig transmissible that is used for the treatment of according to claim 1, it is characterized in that, described feed is comprised of the raw material of following parts by weight: rice 50-70 weight portion, seed of Job's tears 30-50 weight portion, wheat bran 30-50 weight portion, lily root flour 10-20 weight portion, whey powder 15-25 weight portion, SDPP 10-15 weight portion and be used for the treatment of the medicine 8-12 weight portion of porcine contagious pleuropneumonia.
3. the pleuritic feed of pig transmissible that is used for the treatment of according to claim 1 and 2, it is characterized in that, described feed is comprised of the raw material of following parts by weight: rice 55-65 weight portion, seed of Job's tears 35-45 weight portion, wheat bran 35-45 weight portion, lily root flour 13-18 weight portion, whey powder 18-23 weight portion, SDPP 12-14 weight portion and be used for the treatment of the medicine 9-11 weight portion of porcine contagious pleuropneumonia.
4. according to being used for the treatment of the pleuritic feed of pig transmissible described in claim 1-3 any one, it is characterized in that, described medicine comprises following raw medicinal material: the bark of official magnolia, cynanchum paniculatum, OVIDUCTUS RANNAE, lepidium seed, the root of large-flowered skullcap, the coptis, sensitive plant, elongated swertia herb, rhodiola root, caulis bambusae in taenian, meter Lu, reed rhizome, radish seed, Japanese Raspberry Root, spinyleaf pricklyash root, Smallfruit Fig Aerial Root, stephanotis, Hui Bao, Mao Li and lanceleaf thermopsis herb.
5. according to the feed that is used for the treatment of porcine contagious pleuropneumonia described in claim 1-4 any one, it is characterized in that, described medicine is comprised of the raw medicinal material of following parts by weight: bark of official magnolia 20-30 weight portion, cynanchum paniculatum 15-25 weight portion, OVIDUCTUS RANNAE 10-20 weight portion, lepidium seed 10-20 weight portion, root of large-flowered skullcap 20-30 weight portion, coptis 20-30 weight portion, sensitive plant 20-30 weight portion, elongated swertia herb 10-30 weight portion, rhodiola root 10-20 weight portion, caulis bambusae in taenian 10-30 weight portion, rice reveals 20-30 weight portion, reed rhizome 10-20 weight portion, radish seed 10-30 weight portion, Japanese Raspberry Root 10-20 weight portion, spinyleaf pricklyash root 10-20 weight portion, Smallfruit Fig Aerial Root 10-20 weight portion, stephanotis 10-20 weight portion, ash bag 10-20 weight portion, Mao Li 20-30 weight portion and lanceleaf thermopsis herb 5-10 weight portion.
6. according to the feed that is used for the treatment of porcine contagious pleuropneumonia described in claim 1-5 any one, it is characterized in that, described medicine is comprised of the raw medicinal material of following parts by weight: bark of official magnolia 23-27 weight portion, cynanchum paniculatum 17-23 weight portion, OVIDUCTUS RANNAE 13-17 weight portion, lepidium seed 12-18 weight portion, root of large-flowered skullcap 23-27 weight portion, coptis 22-28 weight portion, sensitive plant 23-28 weight portion, elongated swertia herb 15-20 weight portion, rhodiola root 13-18 weight portion, caulis bambusae in taenian 14-23 weight portion, rice reveals 23-28 weight portion, reed rhizome 13-17 weight portion, radish seed 15-26 weight portion, Japanese Raspberry Root 13-17 weight portion, spinyleaf pricklyash root 13-17 weight portion, Smallfruit Fig Aerial Root 12-18 weight portion, stephanotis 13-18 weight portion, ash bag 13-15 weight portion, Mao Li 23-29 weight portion and lanceleaf thermopsis herb 5-8 weight portion.
7. according to the medicine that is used for the treatment of porcine contagious pleuropneumonia described in claim 1-6 any one, it is characterized in that, described medicine also comprises: Chinese yam, pawpaw, Divine Comedy, auricularia auriculajudae and hawthorn.
8. according to the medicine that is used for the treatment of porcine contagious pleuropneumonia described in claim 1-7 any one, it is characterized in that, described medicine is comprised of the raw medicinal material of following parts by weight: bark of official magnolia 20-30 weight portion, cynanchum paniculatum 15-25 weight portion, OVIDUCTUS RANNAE 10-20 weight portion, lepidium seed 10-20 weight portion, root of large-flowered skullcap 20-30 weight portion, coptis 20-30 weight portion, sensitive plant 20-30 weight portion, elongated swertia herb 10-30 weight portion, rhodiola root 10-20 weight portion, caulis bambusae in taenian 10-30 weight portion, rice reveals 20-30 weight portion, reed rhizome 10-20 weight portion, radish seed 10-30 weight portion, Japanese Raspberry Root 10-20 weight portion, spinyleaf pricklyash root 10-20 weight portion, Smallfruit Fig Aerial Root 10-20 weight portion, stephanotis 10-20 weight portion, ash bag 10-20 weight portion, Mao Li 20-30 weight portion, lanceleaf thermopsis herb 5-10 weight portion, Chinese yam 10-20 weight portion, pawpaw 10-20 weight portion, Divine Comedy 10-20 weight portion, auricularia auriculajudae 10-20 weight portion and hawthorn 10-20 weight portion.
9. according to the feed that is used for the treatment of porcine contagious pleuropneumonia described in claim 1-8 any one, it is characterized in that, the preparation method of described medicine comprises the following steps:
A, cross 120 order dusting covers after described raw medicinal material is put into pulverizer and pulverized, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%～40%, collects by the raw material fine powder of 120 mesh sieves, and particle remaining after sieving is standby;
B, particle remaining after sieving is put into the ethanol heating and refluxing extraction twice that the determining alcohol of 5～7 times of amounts is 85%, each 1～2 hour, extracted twice liquid is merged standing, obtain extract 1, the dregs of a decoction are standby;
C, the dregs of a decoction that in step b, alcohol extract is crossed are added to 5～7 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, No. 2 extracts are merged standing, obtain extract 2;
D, extract 1 and extract 2 merged, filter 1.38 filtrate when reduced pressure concentration relative density is 50 ℃～60 ℃, reclaim ethanol, gained filtrate is adjusted to proportion to 1.06, pass into spray dryer and spray dryly, the compressed air pressure of mistake spray dryer shower nozzle is 4kg/m
2, hothouse hot stream temperature is 100 ℃, obtains raw material medicinal powder; The medicine that the raw material fine powder obtaining after step a is sieved mixes with raw material medicinal powder.
10. a preparation method for the feed that is used for the treatment of porcine contagious pleuropneumonia as described in claim 1-9 any one, is characterized in that, described preparation method comprises the following steps:
The first step, take by ratio of weight and the number of copies rice, the seed of Job's tears, wheat bran, lily root flour, whey powder, SDPP and be used for the treatment of the medicine of porcine contagious pleuropneumonia, dropping into pulverizer pulverizes, grinding particle size is 200-300 order, by the mixture after pulverizing and input mixer, mix the uniformity≤5% of mixing;
Second step, pours into after mixing in the granulating disc that is placed in heeling condition and carries out granulation, and the rotating speed of granulating disc is 50 revs/min, and preparation time is 15 minutes, is prepared into diameter and is the spherical particle feed of 1 millimeter;
The 3rd step, the spherical particle feed that second step is obtained, spreads in having on the mesh-belt drier of the portable stainless steel guipure of multilayer, heat drying 15 minutes, the import air temperature of heating is 140 ℃, outlet air temperature is 70 ℃, obtains dry feed granules.
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| CN104256168A (en) * | 2014-09-28 | 2015-01-07 | 山东新希望六和集团有限公司 | Pig functional feed and preparation method thereof |
| CN105998282A (en) * | 2016-05-27 | 2016-10-12 | 施瑞客（天津）生物技术有限公司 | Traditional Chinese medicinal composition for treating contagious bovine pleuropneumonia in cows and preparation method of traditional Chinese medicinal composition |
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Effective date of registration: 20171116 Address after: Nansha District Lanhe town Guangzhou city Guangdong province 510080 on Dong Di Ni Village Patentee after: Guangzhou Hope Feed Co., Ltd. Address before: 266061 Shandong city of Qingdao province Chengyang Jihongtan Street Green Industrial Park Patentee before: Shandong New Hope Liuhe Group Co., Ltd. |
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