CN104524162A - Composite fermentation type traditional Chinese medicine for improving stress resistance of livestock and poultry and preparation method of composite fermentation type traditional Chinese medicine - Google Patents
Composite fermentation type traditional Chinese medicine for improving stress resistance of livestock and poultry and preparation method of composite fermentation type traditional Chinese medicine Download PDFInfo
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Abstract
The invention discloses a composite fermentation type traditional Chinese medicine for improving stress resistance of livestock and poultry. The composite fermentation type traditional Chinese medicine is prepared from the following active pharmaceutical ingredients in parts by weight: 10-40 parts of lancelesf lily bulbs, 20-60 parts of kudzuvine root, 10-50 parts of silktree albizzia bark, 40-80 parts of cortex acanthopanacis radicis, 40-80 parts of eucommia bark, 5-25 parts of liquorice root, 10-40 parts of common anemarrhena rhizome and 5-20 parts of gypsum. The composite fermentation type traditional Chinese medicine is prepared by combining a traditional Chinese medicine recipe with a modern microbial technology, adding wheat bran, soybean meal, ammonium sulfate, magnesium sulfate, calcium carbonate and an appropriate amount of water after ultrasonic crushing to constitute a fermentation culture medium, adding a certain proportion of a strain culture solution of composite bacteria, fermentating, adding a stabilizer into a mature solid fermented matter, and performing low-temperature drying for preparation. The traditional Chinese medicine biological preparation prepared after microbial fermentation metabolism can significantly improve absorption and utilization of the medicine, improve the stress resistance of organisms of livestock and poultry, strengthen the immunity of the organisms, improve the production performance of livestock and poultry, effectively prevent and treat immunity suppression diseases and stress diseases and the like.
Description
Technical field
The invention belongs to herbal medicine technical field, be specifically related to a kind of for Composite fermentation type Chinese medicine improving poultry anti-stress and preparation method thereof.
Background technology
Poultry in feeding and management process, due to the factor of environment, weather factor caused by stress; Due to the stress that nutritional imbalance, some nutrient deficiency and deficiency cause; What the physiology caused due to pathological factor, pathological change caused stress; Due to management factors cause stress, the resistance against diseases caused reduces, fertility performance declines, the physical signs such as immunity weakens change all can work the mischief to animal body, make that poultry spirit is depressed, feed intake declines, the speed of growth slows down, the phenomenon of body caused body microecological balance imbalance under environmental effect is comparatively general, the generation frequency is higher, is usually ignored by people.
Chinese veterinarian's disease therapy is resist exopathogenic factor to invade by cultivating vigour in body the QI and blood change caused substantially, fundamentally can improve body constitution and promote rehabilitation.And modern age, doctor trained in Western medicine advocated solution disease for first, alleviated apparent.Positive so-called Western medicine bactericidal antiphlogistic is controlled " mark ", Chinese medicine enhancing body anti pathologic immunity function, is positive controlling " basis ".Chinese medicine is natural green medicine, not easily causes receptor drug resistance and sequela, noresidue, ensures food safety.Improve absorbing of its effective ingredient and health-care effect by the fermentation of microbial ecological agent simultaneously.
Veterinary often uses Chinese powder medicine and oral liquid etc., and compound fermentation Chinese medicine is a kind of novel special dosage form on veterinary drug.Modern herbal medicine theory is pointed out, a herb has nearly more than 300 plants active ingredient, usually can not play its due effect completely, can only do some make up by escalated dose, cause and utilize herbal medicine disease therapy high cost.The physiological characteristics of birds is that intestinal is short and small in addition, and content excreted at 3-4 hour, and make absorption not thorough, trap only has about 30%.
Summary of the invention
The technical problem to be solved in the present invention is that effective ingredient in the Chinese powder medicine of common poultry anti-stress and oral liquid is because absorb not thorough, and its due effect can not be played completely, for solving the problem, the invention provides a kind of for Composite fermentation type Chinese medicine improving poultry anti-stress and preparation method thereof.
The object of the invention is to realize in the following manner:
For improving a Composite fermentation type Chinese medicine for poultry anti-stress, be made up of the crude drug of following weight portion: Bulbus Lilii 10-40 part, Radix Puerariae 20-60 part, Cortex Albiziae 10-50 part, Cortex Acanthopancis 40-80 part, Cortex Eucommiae 40-80 part, Radix Glycyrrhizae 5-25 part, Rhizoma Anemarrhenae 10-40 part, Gypsum Fibrosum 5-20 part.
Be made up of the crude drug of following weight portion: Bulbus Lilii 15-30 part, Radix Puerariae 30-50 part, Cortex Albiziae 20-40 part, Cortex Acanthopancis 50-70 part, Cortex Eucommiae 50-70 part, Radix Glycyrrhizae 5-15 part, Rhizoma Anemarrhenae 10-25 part, Gypsum Fibrosum 5-15 part.
Be made up of the crude drug of following weight portion: Bulbus Lilii 20 parts, Radix Puerariae 40 parts, Cortex Albiziae 30 parts, Cortex Acanthopancis 60 parts, the Cortex Eucommiae 60 parts, 10 parts, Radix Glycyrrhizae, the Rhizoma Anemarrhenae 20 parts, 10 parts, Gypsum Fibrosum.
Concrete steps are:
(1) take each component by weight, carry out micronizing process, cross 80-120 mesh sieve, obtain Chinese medicine powder;
(2), after the Chinese medicine powder that step (1) obtains being carried out high temperature sterilize, add culture medium and composite bacteria liquid, obtain compound;
(3) compound that step (2) obtained drops in fermentation tank, 25-45 DEG C of bottom fermentation 12 ~ 24 hours, obtains tunning, naturally cools to room temperature, add stabilizing agent, then carry out vacuum dehydrating at lower temperature, subpackage, store.
Described culture medium is made up of the component of following mass percent: in Chinese medicine gross mass for radix, wheat bran 20-30%, bean cake 3-4%, ammonium sulfate 1-2%, magnesium sulfate 0.5-1%, calcium carbonate 1-2% and water 20-30%.
Described composite bacteria liquid is 1-5 part, and the concrete preparation method of composite bacteria liquid is:
A. extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation respectively as strain respectively, the bacterium colony normal saline eluting that often kind of slant culture produces is added in cultured solution of broth and makes suspension, and then amplification culture is distinguished in appropriate media, be cultured to exponential phase 0.5 × 10
8cFU/mL to 1.0 × 10
8during CFU/mL only;
B. the lactobacillus suspension, yeast liquid, streptococcus faecalis liquid and the bacillus liquid that are obtained by step a are according to 1:(0.35 ~ 0.65): (0.4 ~ 0.6): (0.4 ~ 0.6) ratio is mixed to get composite bacteria liquid.
Described stabilizing agent is made up of sodium benzoate and propyl gallate, and the addition of sodium benzoate is 0.03 ~ 0.06% of step (3) tunning gross mass, and the addition of propyl gallate is 0.006 ~ 0.010% of step (3) tunning gross mass.
Described vacuum dehydrating at lower temperature temperature is 0 ~ 4 DEG C, drying time 12 ~ 16h.
The effect of each taste Chinese medicine in the present invention:
Bulbus Lilii nourishing the lung to arrest cough, clearing away heart-fire for tranquillization, invigorating the spleen and replenishing QI, clearing away heat and promoting diuresis, heat-clearing and toxic substances removing, cooling blood for hemostasis, invigorating the spleen and regulating the stomach.
Radix Puerariae has to induce sweat brings down a fever, and promotes the production of body fluid, rash, effect of yang invigorating antidiarrheal.For fever caused by exogenous pathogens headache, hypertension neck pain, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, to have loose bowels.Radix Puerariae flavone has cancer-resisting and estrogen-like effects.Body function can be regulated, health invigorating, improve body resistance against diseases.
The effect that Cortex Albiziae has soothing nerves and assisting sleep to sleep, has the merit of resolving depression and blood, mind calming, subduing inflammation.Have control irritability, melancholy, insomnia, effect.
Cortex Acanthopancis has antiinflammatory, calmness, analgesia, Cadmium resistance mutagenic action and anti-stress effect, the synthesis of promotion nucleic acid, gonadotropic Effect.
Cortex Eucommiae invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Cure mainly soreness of waist and knee joint, sexual impotence, seminal emission, frequent micturition, dribbling urination, yang hyperactivity is dizzy, rheumatic arthralgia, and uncontrolled urination is itched, frequent fetal movement, leaks tire abortion.The Cortex Eucommiae can strengthen the vigor of mouse red blood cell SOD, and strengthens its adrenal gland's weight.The Cortex Eucommiae can make low physiological function recover normal, and the prompting Cortex Eucommiae has certain anti-aging effects.The 26S Proteasome Structure and Function of the various trace elements be rich in the Cortex Eucommiae and human endocrine system, immune function system, growth promoter system has substantial connection, particularly has substantial connection with defying age.As zinc can the reparation of acceleration of wound, ulcer, surgical wound etc., play specificity to lymphocyte and urge fissional effect, this shows that zinc has delaying senility function.
Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Rhizoma Anemarrhenae nourishing YIN to lower pathogenic fire, moisturizes laxation.Control dysphoria with smothery sensation to quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.
Gypsum Fibrosum expelling pathogenic factors from muscles for clearing heat; Relieving restlessness is quenched the thirst.Main calentura high fever does not move back; Vexed coma; Delirium is gone mad; Thirsty and dry pharynx; Lung-heat dyspnea with rapid respiration; Heatstroke spontaneous perspiration; Stomach-fire is had a headache; Toothache due to stomach-fire; Hyperactivity of toxic heat; Send out speckle dermexanthesis; Aphtha of the mouth and tongue; Ulcer sores; Burst and do not close up; The burning hot wound of soup.For fever caused by exogenous pathogenic factors, high hot excessive thirst, dyspnea and cough due to lung-heat, the high Sheng of stomach-fire, headache, toothache.
In a word, in formula of the present invention, Cortex Acanthopancis, the Cortex Eucommiae are monarch drug, the arduous temperature of Cortex Acanthopancis, return liver, kidney channel, wind-damp dispelling, liver and kidney tonifying, bone and muscle strengthening, inducing diuresis to remove edema, Cortex Eucommiae taste acrid-sweet flavor, warm in nature flat, enter kidney channel, liver and kidney tonifying, bone and muscle strengthening, Chong and Ren Meridians regulating, solid through antiabortive, two medicine helps are for using, have conditioning Liver and kidney, Yin Yang balancing, alleviating occur in livestock and poultry cultivation various stress; Bulbus Lilii, Radix Puerariae are ministerial drug, and the sweet micro-hardship of Bulbus Lilii is slightly cold, GUIXIN; Lung meridian, nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization, can carry his medicine and enter liver, Radix Puerariae is sweet pungent cool, attaches to the lung and stomach meridians, expelling pathogenic factors from muscles for reducing heat, and promote the production of body fluid yang invigorating, and two medicines share, clearing away heart-fire for tranquillization, yin nourishing yang invigorating; Cortex Albiziae, the Rhizoma Anemarrhenae are adjuvant drug, and the bitter Wen Ganping of Cortex Albiziae, enters the heart, Liver Channel, resolving depression of calming the nerves, promoting blood circulation and detumescence, nourshing Yin and drynsessmoistening prescription; Rhizoma Anemarrhenae bitter in the mouth is trembled with fear, and property is put down, and enters lung, stomach, kidney channel, nourishing YIN to lower pathogenic fire, moisturizes laxation.Gypsum Fibrosum is sweet pungent cold, attaches to the lung and stomach meridians, expelling pathogenic factors from muscles for clearing heat, and relieving restlessness is quenched the thirst, and Radix Glycyrrhizae is sweet flat, and replenishing QI to invigorate the spleen, clearing away heat-fire, coordinating the actions of various ingredients in a prescription, altogether for making medicine.Therefore, full side demonstrate effectively can treat that a variety of causes in livestock and poultry cultivation causes stress effect.Invention enhances the function that body regulates, be highly resistant to poultry various stress, eliminate the various damp production that stress cause or low, alleviate the potential safety hazard that chemical medicine causes, add the safety of medication.
Positive beneficial effect of the present invention:
(1) from traditional Chinese veterinary medicine angle analysis, " exogenous pathogen mutual aid " is numerous disease predisposing factors, and when the five internal organs that namely traditional Chinese medical science is said are in " void ", virus is taken advantage of a weak point, and causes pathogen being excessive but vital QI weak, disease-resistant unable; Many because of the damp and hot fire-transformation of diseases caused by exogenous pathogenic factor, cause inhibited pulmonary QI, abnormal ascending-descending of QI, imbalance of YIN and YANG.Chinese herbal medicine can YIN and YANG balance regulating, treating both the principal and secondary aspects of a disease, make body constitutionally, immunity is thought and acted in one and the same way, equilibrium between yin and yang, thus reach the ideal cultivation state of " ill to send out less, morbidity die less ".The present invention's science of being carried out by various Chinese medicine reasonable compatibility is extracted and is used, and plays the complementary action of different mechanism of action, thus plays the effect of stronger anti-stress ability.
(2) safety of the present invention is high, and through acute oral toxicity test, local excitation test and pyrogenic test, animal subject is in a good state of health, and does not all occur untoward reaction.
(3) the present invention has wind and heat dispersing, removing pathogenic heat from blood and toxic substance from the body, antiinflammatory, invigorating the liver and kidney, bone and muscle strengthening, heart tonifying, antiinflammatory, calmness, analgesia, Cadmium resistance mutagenic action and anti-stress effect, invigorating the spleen and regulating the stomach, the effect of raising immunity of organisms, be mainly used in improving poultry resisting stress capability, enhancing human body immunity power, improve the fertility performance of poultry, effective disease preventing and treating and stress disease etc.
The present invention adopts controlled release and targeting technology, makes medicine directly can arrive target position, and extends effective time, transformed simultaneously by micro-ecology fermentation, enhance the curative effect of Chinese herbal medicine, improve the microecological balance of body; Adopt microbial fermentation technology, the effective ingredient of medicine is converted into and is easy to absorb and fast onset effect, adopt ultrasonic grinding technology simultaneously, effective ingredient is not destroyed, ensure that effective ingredient is sufficient, drug effect increases; Ensure the core technology of product, ensure quality and the curative effect of product; Adopt advanced finger print identification technology, ensure that the quality of selected Chinese crude drug is excellent level.
Advantage of the present invention is specific as follows:
1, drug effect plays rapidly, and side effect is little, and the time that plays a role is short, easy to use.
The present invention through ultrasonic grinding and cell wall wall breaking technology, then carries out fermentable, and direct spice uses.Prove according to 3000 broiler clinical trials, haul oneself willingly into observation post administration, chicken appetite of mining massively improves, and keeps Intestine of Broiler stable acidic environment, intestinal is made to keep low ph value, suppress harmful intestinal tract bacteria increment, for probiotics provides nutrition, improve immunity of meat chickens and anti-stress ability, quick reparation damaged organ, improve broiler health, reduce mortality rate, improve meat chicken production performance and economic benefit.
2, drug absorption is abundant, and the persistent period that plays a role is long, lasting medicine.
Through comparing: normal Chinese herbal medicine stops 2-6 hour at digestive system, and after fermentable process, be 8-12 hour in the effective time of birds digestive system, substantially prolongs the time of staying in intestinal, absorption rate significantly increases, and through comparing, common Chinese (40-60 order) can detect a large amount of Chinese medicine prototypes after discharging with feces in intestinal, and Composite fermentation type Chinese medicine prepared by the present invention is after discharging through feces, almost can't check.MIC also obviously differs simultaneously, and Composite fermentation type Chinese medicine prepared by the present invention is higher than common Chinese by 95%.
3, body non-specific immunity strengthens, and anti-stress ability strengthens, and premunition strengthens, and protective rate improves.
Throw and take Composite fermentation type Chinese medicine prepared by the present invention and throw the broiler taking common Chinese, after feeding 4 days, obviously occur difference, as shown in table 1.
The result of the test after chicken medication respectively organized by table 1
Chinese medicine prescription combines with Modern microbiological technology and prepares a kind of traditional Chinese biological preparation by the present invention, said preparation is for raw material with Bulbus Lilii, Radix Puerariae, Cortex Albiziae, Cortex Acanthopancis, the Cortex Eucommiae, Radix Glycyrrhizae, the Rhizoma Anemarrhenae, Gypsum Fibrosum, wheat bran, bean cake, ammonium sulfate, magnesium sulfate, calcium carbonate and suitable quantity of water composition fermentation medium is added after ultrasonic grinding, add a certain proportion of compound bacteria bacteria culture fluid, ferment, ripe solid fermentation thing adds stabilizing agent, carries out cold drying and is prepared from.Traditional Chinese biological preparation prepared after fermentable metabolism, absorbing of medicine can be significantly improved, improve poultry resisting stress capability, enhancing human body immunity power, improve the fertility performance of poultry, effectively control immunosuppressive disease and stress disease etc.
Common Chinese was just excreted at 3-4 hour, and make absorption thorough, trap only has about 30%, and fermented type Chinese medicine is almost all absorbed in section at this moment.Compound fermentation Chinese medicinal ointment be Chinese herbal medicine through ultrasonic grinding, then add compound bacteria-fermented and form, the efficient composition such as albumen, tannin, starch in not removed Chinese herbal medicine, and these compositions play vital effect in treatment of diseases.Be converted into the composition that body is convenient to absorb simultaneously with microbial action, accelerate health care and treatment speed, improve health-care effect and curative effect, improve the microecological environment of body, improve animal spontaneous recovery and resistance against diseases, improve animal feed rate of returns.As can be seen here, compound fermentation Chinese medicine is greatly be better than other form of Chinese drug on pharmacological effect.
Detailed description of the invention
Following composite bacteria liquid self-control or commercially available, described various increasing bacterial context soup is commercially available, and addition performs according to national standard.
Embodiment 1:
For improving a Composite fermentation type Chinese medicine for poultry anti-stress, be made up of the crude drug of following weight portion: Bulbus Lilii 10-40 part, Radix Puerariae 20-60 part, Cortex Albiziae 10-50 part, Cortex Acanthopancis 40-80 part, Cortex Eucommiae 40-80 part, Radix Glycyrrhizae 5-25 part, Rhizoma Anemarrhenae 10-40 part, Gypsum Fibrosum 5-20 part.
Concrete steps are:
(1) take each component by weight, carry out micronizing process, cross 80-120 mesh sieve, obtain Chinese medicine powder;
(2), after the Chinese medicine powder that step (1) obtains being carried out high temperature sterilize, add culture medium and composite bacteria liquid, obtain compound;
(3) compound that step (2) obtained drops in fermentation tank, 25-45 DEG C of bottom fermentation 12 ~ 24 hours, obtains tunning, naturally cools to room temperature, add stabilizing agent, then carry out vacuum dehydrating at lower temperature, subpackage, store.
Described culture medium is made up of the component of following mass percent: in Chinese medicine gross mass for radix, wheat bran 20-30%, bean cake 3-4%, ammonium sulfate 1-2%, magnesium sulfate 0.5-1%, calcium carbonate 1-2% and water 20-30%.
Described composite bacteria liquid is 1-5 part, and the concrete preparation method of composite bacteria liquid is:
A. extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation respectively as strain respectively, the bacterium colony normal saline eluting that often kind of slant culture produces is added in cultured solution of broth and makes suspension, and then amplification culture is distinguished in appropriate media, be cultured to exponential phase 0.5 × 10
8cFU/mL to 1.0 × 10
8during CFU/mL only;
B. the lactobacillus suspension, yeast liquid, streptococcus faecalis liquid and the bacillus liquid that are obtained by step a are according to 1:(0.35 ~ 0.65): (0.4 ~ 0.6): (0.4 ~ 0.6) ratio is mixed to get composite bacteria liquid.
Described stabilizing agent is made up of sodium benzoate and propyl gallate, and the addition of sodium benzoate is 0.03 ~ 0.06% of step (3) tunning gross mass, and the addition of propyl gallate is 0.006 ~ 0.010% of step (3) tunning gross mass.
Described vacuum dehydrating at lower temperature temperature is 0 ~ 4 DEG C, drying time 12 ~ 16h.
The usage of medicine and consumption: in feedstuff gross mass 0.5 ~ 1% ratio make an addition in feedstuff and throw something and feed.
Embodiment 2:
A kind of Composite fermentation type Chinese medicine for improving poultry anti-stress, fermented by Chinese medicine, culture medium and composite bacteria liquid mixing closing anaerobic and make, described Chinese medicine is made up of the crude drug of following weight portion: Bulbus Lilii 100g, Radix Puerariae 200g, Cortex Albiziae 100g, Cortex Acanthopancis 400g, Cortex Eucommiae 400g, Radix Glycyrrhizae 50g, Rhizoma Anemarrhenae 100g, Gypsum Fibrosum 50g.
Concrete steps are:
(1) take each component by weight, carry out micronizing process, cross 80-120 mesh sieve, obtain Chinese medicine powder;
(2), after the Chinese medicine powder that step (1) obtains being carried out high temperature sterilize, add culture medium and composite bacteria liquid, obtain compound;
(3) compound that step (2) obtained drops in fermentation tank, 25 DEG C of bottom fermentations 12 hours, obtains tunning, naturally cools to room temperature, add stabilizing agent, then carry out vacuum dehydrating at lower temperature, subpackage, store.
Described culture medium is made up of the component of following mass percent: in Chinese medicine gross mass for radix, wheat bran 20%, bean cake 3%, ammonium sulfate 1%, magnesium sulfate 0.5%, calcium carbonate 1% and water 20%.
Described composite bacteria liquid is 10g, and the concrete preparation method of composite bacteria liquid is:
A. extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation respectively as strain respectively, the bacterium colony normal saline eluting that often kind of slant culture produces is added in cultured solution of broth and makes suspension, and then amplification culture is distinguished in appropriate media, be cultured to exponential phase 0.5 × 10
8during CFU/mL only;
B. lactobacillus suspension, yeast liquid, streptococcus faecalis liquid and bacillus liquid that step a is obtained are mixed to get composite bacteria liquid according to 1:0.35:0.4:0.4 ratio.
Described stabilizing agent is made up of sodium benzoate and propyl gallate, and the addition of sodium benzoate is 0.03% of step (3) tunning gross mass, and the addition of propyl gallate is 0.006% of step (3) tunning gross mass.
Described vacuum dehydrating at lower temperature temperature is 0 DEG C, drying time 12h.
Embodiment 3:
A kind of Composite fermentation type Chinese medicine for improving poultry anti-stress, fermented by Chinese medicine, culture medium and composite bacteria liquid mixing closing anaerobic and make, described Chinese medicine is made up of the crude drug of following weight portion: Bulbus Lilii 150g, Radix Puerariae 250g, Cortex Albiziae 150g, Cortex Acanthopancis 450g, Cortex Eucommiae 450g, Radix Glycyrrhizae 75g, Rhizoma Anemarrhenae 150g, Gypsum Fibrosum 75g.
Concrete steps are:
(1) take each component by weight, carry out micronizing process, cross 80-120 mesh sieve, obtain Chinese medicine powder;
(2), after the Chinese medicine powder that step (1) obtains being carried out high temperature sterilize, add culture medium and composite bacteria liquid, obtain compound;
(3) compound that step (2) obtained drops in fermentation tank, 30 DEG C of bottom fermentations 15 hours, obtains tunning, naturally cools to room temperature, add stabilizing agent, then carry out vacuum dehydrating at lower temperature, subpackage, store.
Described culture medium is made up of the component of following mass percent: in Chinese medicine gross mass for radix, wheat bran 22%, bean cake 3.2%, ammonium sulfate 1.2%, magnesium sulfate 0.6%, calcium carbonate 1.2% and water 22%.
Described composite bacteria liquid is 20g, and the concrete preparation method of composite bacteria liquid is:
A. extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation respectively as strain respectively, the bacterium colony normal saline eluting that often kind of slant culture produces is added in cultured solution of broth and makes suspension, and then amplification culture is distinguished in appropriate media, be cultured to exponential phase 0.6 × 10
8during CFU/mL only;
B. lactobacillus suspension, yeast liquid, streptococcus faecalis liquid and bacillus liquid that step a is obtained are mixed to get composite bacteria liquid according to 1:0.4:0.45:0.45 ratio.
Described stabilizing agent is made up of sodium benzoate and propyl gallate, and the addition of sodium benzoate is 0.04% of step (3) tunning gross mass, and the addition of propyl gallate is 0.007% of step (3) tunning gross mass.
Described vacuum dehydrating at lower temperature temperature is 1 DEG C, drying time 13h.
Embodiment 4:
A kind of Composite fermentation type Chinese medicine for improving poultry anti-stress, fermented by Chinese medicine, culture medium and composite bacteria liquid mixing closing anaerobic and make, described Chinese medicine is made up of the crude drug of following weight portion: Bulbus Lilii 200g, Radix Puerariae 300g, Cortex Albiziae 200g, Cortex Acanthopancis 500g, Cortex Eucommiae 500g, Radix Glycyrrhizae 100g, Rhizoma Anemarrhenae 200g, Gypsum Fibrosum 100g.
Concrete steps are:
(1) take each component by weight, carry out micronizing process, cross 80-120 mesh sieve, obtain Chinese medicine powder;
(2), after the Chinese medicine powder that step (1) obtains being carried out high temperature sterilize, add culture medium and composite bacteria liquid, obtain compound;
(3) compound that step (2) obtained drops in fermentation tank, 35 DEG C of bottom fermentations 18 hours, obtains tunning, naturally cools to room temperature, add stabilizing agent, then carry out vacuum dehydrating at lower temperature, subpackage, store.
Described culture medium is made up of the component of following mass percent: in Chinese medicine gross mass for radix, wheat bran 24%, bean cake 3.4%, ammonium sulfate 1.4%, magnesium sulfate 0.7%, calcium carbonate 1.4% and water 24%.
Described composite bacteria liquid is 30g, and the concrete preparation method of composite bacteria liquid is:
A. extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation respectively as strain respectively, the bacterium colony normal saline eluting that often kind of slant culture produces is added in cultured solution of broth and makes suspension, and then amplification culture is distinguished in appropriate media, be cultured to exponential phase 0.8 × 10
8during CFU/mL only;
B. lactobacillus suspension, yeast liquid, streptococcus faecalis liquid and bacillus liquid that step a is obtained are mixed to get composite bacteria liquid according to 1:0.5:0.5:0.5 ratio.
Described stabilizing agent is made up of sodium benzoate and propyl gallate, and the addition of sodium benzoate is 0.05% of step (3) tunning gross mass, and the addition of propyl gallate is 0.008% of step (3) tunning gross mass.
Described vacuum dehydrating at lower temperature temperature is 2 DEG C, drying time 14h.
Embodiment 5:
A kind of Composite fermentation type Chinese medicine for improving poultry anti-stress, fermented by Chinese medicine, culture medium and composite bacteria liquid mixing closing anaerobic and make, described Chinese medicine is made up of the crude drug of following weight portion: Bulbus Lilii 250g, Radix Puerariae 350g, Cortex Albiziae 250g, Cortex Acanthopancis 550g, Cortex Eucommiae 550g, Radix Glycyrrhizae 125g, Rhizoma Anemarrhenae 250g, Gypsum Fibrosum 125g.
Concrete steps are:
(1) take each component by weight, carry out micronizing process, cross 80-120 mesh sieve, obtain Chinese medicine powder;
(2), after the Chinese medicine powder that step (1) obtains being carried out high temperature sterilize, add culture medium and composite bacteria liquid, obtain compound;
(3) compound that step (2) obtained drops in fermentation tank, 40 DEG C of bottom fermentations 21 hours, obtains tunning, naturally cools to room temperature, add stabilizing agent, then carry out vacuum dehydrating at lower temperature, subpackage, store.
Described culture medium is made up of the component of following mass percent: in Chinese medicine gross mass for radix, wheat bran 26%, bean cake 3.6%, ammonium sulfate 1.6%, magnesium sulfate 0.8%, calcium carbonate 1.6% and water 26%.
Described composite bacteria liquid is 40g, and the concrete preparation method of composite bacteria liquid is:
A. extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation respectively as strain respectively, the bacterium colony normal saline eluting that often kind of slant culture produces is added in cultured solution of broth and makes suspension, and then amplification culture is distinguished in appropriate media, be cultured to exponential phase 0.9 × 10
8during CFU/mL only;
B. lactobacillus suspension, yeast liquid, streptococcus faecalis liquid and bacillus liquid that step a is obtained are mixed to get composite bacteria liquid according to 1:0.6:0.55:0.55 ratio.
Described stabilizing agent is made up of sodium benzoate and propyl gallate, and the addition of sodium benzoate is 0.055% of step (3) tunning gross mass, and the addition of propyl gallate is 0.009% of step (3) tunning gross mass.
Described vacuum dehydrating at lower temperature temperature is 3 DEG C, drying time 15h.
Embodiment 6:
A kind of Composite fermentation type Chinese medicine for improving poultry anti-stress, fermented by Chinese medicine, culture medium and composite bacteria liquid mixing closing anaerobic and make, described Chinese medicine is made up of the crude drug of following weight portion: Bulbus Lilii 300g, Radix Puerariae 400g, Cortex Albiziae 300g, Cortex Acanthopancis 600g, Cortex Eucommiae 600g, Radix Glycyrrhizae 150g, Rhizoma Anemarrhenae 300g, Gypsum Fibrosum 150g.
Concrete steps are:
(1) take each component by weight, carry out micronizing process, cross 80-120 mesh sieve, obtain Chinese medicine powder;
(2), after the Chinese medicine powder that step (1) obtains being carried out high temperature sterilize, add culture medium and composite bacteria liquid, obtain compound;
(3) compound that step (2) obtained drops in fermentation tank, 45 DEG C of bottom fermentations 24 hours, obtains tunning, naturally cools to room temperature, add stabilizing agent, then carry out vacuum dehydrating at lower temperature, subpackage, store.
Described culture medium is made up of the component of following mass percent: in Chinese medicine gross mass for radix, wheat bran 28%, bean cake 3.8%, ammonium sulfate 1.8%, magnesium sulfate 0.9%, calcium carbonate 1.8% and water 28%.
Described composite bacteria liquid is 50g, and the concrete preparation method of composite bacteria liquid is:
A. extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation respectively as strain respectively, the bacterium colony normal saline eluting that often kind of slant culture produces is added in cultured solution of broth and makes suspension, and then amplification culture is distinguished in appropriate media, be cultured to exponential phase 1.0 × 10
8during CFU/mL only;
B. lactobacillus suspension, yeast liquid, streptococcus faecalis liquid and bacillus liquid that step a is obtained are mixed to get composite bacteria liquid according to 1:0.65:0.6:0.6 ratio.
Described stabilizing agent is made up of sodium benzoate and propyl gallate, and the addition of sodium benzoate is 0.06% of step (3) tunning gross mass, and the addition of propyl gallate is 0.010% of step (3) tunning gross mass.
Described vacuum dehydrating at lower temperature temperature is 4 DEG C, drying time 16h.
Embodiment 7:
A kind of Composite fermentation type Chinese medicine for improving poultry anti-stress, fermented by Chinese medicine, culture medium and composite bacteria liquid mixing closing anaerobic and make, described Chinese medicine is made up of the crude drug of following weight portion: Bulbus Lilii 350g, Radix Puerariae 450g, Cortex Albiziae 350g, Cortex Acanthopancis 650g, Cortex Eucommiae 650g, Radix Glycyrrhizae 175g, Rhizoma Anemarrhenae 350g, Gypsum Fibrosum 175g.
Described culture medium is made up of the component of following mass percent: in Chinese medicine gross mass for radix, wheat bran 30%, bean cake 4%, ammonium sulfate 2%, magnesium sulfate 1%, calcium carbonate 2% and water 30%.
The other the same as in Example 1.
Embodiment 8:
A kind of Composite fermentation type Chinese medicine for improving poultry anti-stress, fermented by Chinese medicine, culture medium and composite bacteria liquid mixing closing anaerobic and make, described Chinese medicine is made up of the crude drug of following weight portion: Bulbus Lilii 400g, Radix Puerariae 500g, Cortex Albiziae 400g, Cortex Acanthopancis 700g, Cortex Eucommiae 700g, Radix Glycyrrhizae 200g, Rhizoma Anemarrhenae 400g, Gypsum Fibrosum 200g.
The other the same as in Example 1.
Embodiment 9:
A kind of Composite fermentation type Chinese medicine for improving poultry anti-stress, fermented by Chinese medicine, culture medium and composite bacteria liquid mixing closing anaerobic and make, described Chinese medicine is made up of the crude drug of following weight portion: Bulbus Lilii 175g, Radix Puerariae 550g, Cortex Albiziae 450g, Cortex Acanthopancis 750g, Cortex Eucommiae 750g, Radix Glycyrrhizae 225g, Rhizoma Anemarrhenae 175g, Gypsum Fibrosum 180g.
The other the same as in Example 1.
Embodiment 10:
A kind of Composite fermentation type Chinese medicine for improving poultry anti-stress, fermented by Chinese medicine, culture medium and composite bacteria liquid mixing closing anaerobic and make, described Chinese medicine is made up of the crude drug of following weight portion: Bulbus Lilii 375g, Radix Puerariae 600g, Cortex Albiziae 500g, Cortex Acanthopancis 800g, Cortex Eucommiae 800g, Radix Glycyrrhizae 250g, Rhizoma Anemarrhenae 375g, Gypsum Fibrosum 110g.
The other the same as in Example 1.
Embodiment 11:
A kind of Composite fermentation type Chinese medicine for improving poultry anti-stress, fermented by Chinese medicine, culture medium and composite bacteria liquid mixing closing anaerobic and make, described Chinese medicine is made up of the crude drug of following weight portion: Bulbus Lilii 150g, Radix Puerariae 300g, Cortex Albiziae 200g, Cortex Acanthopancis 500g, Cortex Eucommiae 500g, Radix Glycyrrhizae 50g, Rhizoma Anemarrhenae 100g, Gypsum Fibrosum 50g.
The other the same as in Example 1.
Embodiment 12:
A kind of Composite fermentation type Chinese medicine for improving poultry anti-stress, fermented by Chinese medicine, culture medium and composite bacteria liquid mixing closing anaerobic and make, described Chinese medicine is made up of the crude drug of following weight portion: Bulbus Lilii 300g, Radix Puerariae 500g, Cortex Albiziae 400g, Cortex Acanthopancis 700g, Cortex Eucommiae 700g, Radix Glycyrrhizae 150g, Rhizoma Anemarrhenae 250g, Gypsum Fibrosum 150g.
The other the same as in Example 1.
Embodiment 13:
A kind of Composite fermentation type Chinese medicine for improving poultry anti-stress, fermented by Chinese medicine, culture medium and composite bacteria liquid mixing closing anaerobic and make, described Chinese medicine is made up of the crude drug of following weight portion: Bulbus Lilii 200g, Radix Puerariae 400g, Cortex Albiziae 300g, Cortex Acanthopancis 600g, Cortex Eucommiae 600g, Radix Glycyrrhizae 100g, Rhizoma Anemarrhenae 200g, Gypsum Fibrosum 100g.
The other the same as in Example 1.
Clinical trial
Test example 1: Jiaozhuo, Henan plant about 3000 0 Japanese instar chicklings, compound fermentation Chinese medicine composition prepared by Application Example 5, carry out 0.5% feedstuff and add use 48 days, to feed with conventional feed with interpolation common Chinese preparation and compare, chicken appetite of mining massively improves 12.56%, and immunity of meat chickens and anti-stress ability are significantly improved, significantly improve the growth regularity of chicken, improve broiler health, death rate reduces 6.61%, significantly improves meat chicken production performance and economic benefit.
Test example 2: 5000, autotrophy field porkling, because porkling is many, 0 age in days starts compound fermentation Chinese medicine composition prepared by Application Example 7, adopts the mode administration of 1% spice administration, is used in conjunction 48 days, carry out strict sterilization to pig house and surrounding.To feed with conventional feed with interpolation common Chinese preparation and compare, medication after 3 days porkling feed intake rise, medication is after 5 days, and the regularity of pig recovers 75.39% normal, after medication in 10 days, returns to 93.96%; And when adding common Chinese preparation, medication porkling feed intake rising after 6 days, medication is after 10 days, and the regularity of pig recovers 69.91% normally, after medication in 15 days, returns to 89.92%%; And only feed conventional feed time, the situation of porkling shows no signs of improvement substantially.
Above-described is only the preferred embodiment of the present invention, it should be pointed out that for a person skilled in the art, and not departing under general idea prerequisite of the present invention, can also make some changes and improvements, these also should be considered as protection scope of the present invention.
Claims (8)
1. for improving a Composite fermentation type Chinese medicine for poultry anti-stress, it is characterized in that: be made up of the crude drug of following weight portion: Bulbus Lilii 10-40 part, Radix Puerariae 20-60 part, Cortex Albiziae 10-50 part, Cortex Acanthopancis 40-80 part, Cortex Eucommiae 40-80 part, Radix Glycyrrhizae 5-25 part, Rhizoma Anemarrhenae 10-40 part, Gypsum Fibrosum 5-20 part.
2. a kind of Composite fermentation type Chinese medicine for improving poultry anti-stress according to claim 1, it is characterized in that: be made up of the crude drug of following weight portion: Bulbus Lilii 15-30 part, Radix Puerariae 30-50 part, Cortex Albiziae 20-40 part, Cortex Acanthopancis 50-70 part, Cortex Eucommiae 50-70 part, Radix Glycyrrhizae 5-15 part, Rhizoma Anemarrhenae 10-25 part, Gypsum Fibrosum 5-15 part.
3. a kind of Composite fermentation type Chinese medicine for improving poultry anti-stress according to claim 1, is characterized in that: be made up of the crude drug of following weight portion: Bulbus Lilii 20 parts, Radix Puerariae 40 parts, Cortex Albiziae 30 parts, Cortex Acanthopancis 60 parts, the Cortex Eucommiae 60 parts, 10 parts, Radix Glycyrrhizae, the Rhizoma Anemarrhenae 20 parts, 10 parts, Gypsum Fibrosum.
4. the preparation method of a kind of Composite fermentation type Chinese medicine for improving poultry anti-stress according to claim 1, is characterized in that: concrete steps are:
(1) take each component by weight, carry out micronizing process, cross 80-120 mesh sieve, obtain Chinese medicine powder;
(2), after the Chinese medicine powder that step (1) obtains being carried out high temperature sterilize, add culture medium and composite bacteria liquid, obtain compound;
(3) compound that step (2) obtained drops in fermentation tank, 25-45 DEG C of bottom fermentation 12 ~ 24 hours, obtains tunning, naturally cools to room temperature, add stabilizing agent, then carry out vacuum dehydrating at lower temperature, subpackage, store.
5. the preparation method of a kind of Composite fermentation type Chinese medicine for improving poultry anti-stress according to claim 4, it is characterized in that: described culture medium is made up of the component of following mass percent: in Chinese medicine gross mass for radix, wheat bran 20-30%, bean cake 3-4%, ammonium sulfate 1-2%, magnesium sulfate 0.5-1%, calcium carbonate 1-2% and water 20-30%.
6. the preparation method of a kind of Composite fermentation type Chinese medicine for improving poultry anti-stress according to claim 4, it is characterized in that: described composite bacteria liquid is 1-5 part, the concrete preparation method of composite bacteria liquid is:
A. extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation respectively as strain respectively, the bacterium colony normal saline eluting that often kind of slant culture produces is added in cultured solution of broth and makes suspension, and then amplification culture is distinguished in appropriate media, be cultured to exponential phase 0.5 × 10
8cFU/mL to 1.0 × 10
8during CFU/mL only;
B. the lactobacillus suspension, yeast liquid, streptococcus faecalis liquid and the bacillus liquid that are obtained by step a are according to 1:(0.35 ~ 0.65): (0.4 ~ 0.6): (0.4 ~ 0.6) ratio is mixed to get composite bacteria liquid.
7. the preparation method of a kind of Composite fermentation type Chinese medicine for improving poultry anti-stress according to claim 4, it is characterized in that: described stabilizing agent is made up of sodium benzoate and propyl gallate, the addition of sodium benzoate is 0.03 ~ 0.06% of step (3) tunning gross mass, and the addition of propyl gallate is 0.006 ~ 0.010% of step (3) tunning gross mass.
8. the preparation method of a kind of Composite fermentation type Chinese medicine for improving poultry anti-stress according to claim 4, is characterized in that: described vacuum dehydrating at lower temperature temperature is 0 ~ 4 DEG C, drying time 12 ~ 16h.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106074640A (en) * | 2016-06-20 | 2016-11-09 | 陈云海 | A kind of fermented tcm |
| CN111001041A (en) * | 2019-12-10 | 2020-04-14 | 河南亚都实业有限公司 | Anti-inflammatory and antibacterial composite skin scaffold material and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102232487A (en) * | 2011-04-15 | 2011-11-09 | 北京康华远景科技有限公司 | Physiological regulator for maternal animals, and preparation method thereof |
-
2014
- 2014-12-29 CN CN201410832802.9A patent/CN104524162A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102232487A (en) * | 2011-04-15 | 2011-11-09 | 北京康华远景科技有限公司 | Physiological regulator for maternal animals, and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 邓华学等: "《中兽医学》", 28 February 2007, 重庆大学出版社 * |
| 陈桂先等: "《兽药问答》", 30 June 2008, 化学工业出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106074640A (en) * | 2016-06-20 | 2016-11-09 | 陈云海 | A kind of fermented tcm |
| CN111001041A (en) * | 2019-12-10 | 2020-04-14 | 河南亚都实业有限公司 | Anti-inflammatory and antibacterial composite skin scaffold material and preparation method thereof |
| CN111001041B (en) * | 2019-12-10 | 2022-02-01 | 河南亚都实业有限公司 | Anti-inflammatory and antibacterial composite skin scaffold material and preparation method thereof |
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