CN105748644A - Traditional Chinese medicine composition with effects of stopping cough and relieving asthma and preparation method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition with effects of stopping cough and relieving asthma and preparation method of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition with effects of stopping cough and relieving asthma and a preparation method of the traditional Chinese medicine composition, and belongs to the field of modernization of traditional Chinese medicines.The effective constituent of the traditional Chinese medicine composition with effects of stopping cough and relieving asthma is prepared from the following raw materials in parts by weight: 1 part of Herba Ephedrae, 1 part of Semen Armeniacae Amarum, 1 part of Radix Glycyrrhizae and 1 part of Gypsum Fibrosum.The traditional Chinese medicine composition has the advantages that the quality is stable and controllable, the curative effect of the traditional Chinese medicine composition is remarkably higher than that of an existing commercially available dosage form, the taking dosage of a patient is reduced, bioavailability is improved, and economic and social benefits are remarkable.
Description
Technical field
The present invention relates to Chinese medicine composition of a kind of relieving cough, relieving asthma and preparation method thereof, belong to modern Chinese traditional medicine field.
Background technology
Zhisoudingchuankoufuye is the Chinese medicine of presently commercially available a kind of relieving cough, relieving asthma, and its prescription is Herba Ephedrae 1000g, Semen Armeniacae Amarum 1000g, Radix Glycyrrhizae 1000g, Gypsum Fibrosum 1000g.This oral liquid has Xin Liang and leads off, the function of clearing lung, relieving asthma.For exterior cold and interior heat, fever of the body is thirsty, cough with profuse sputum, dyspnea with rapid and short breath QI rising in reverse order, and chest and diaphragm is full vexed；Acute bronchitis is shown in above-mentioned patient.
The method for making of Zhisoudingchuankoufuye is: above four tastes, except Semen Armeniacae Amarum, and the three taste boiling secondaries such as all the other Gypsum Fibrosum, each 1.5 hours, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.05-1.10 (50 DEG C), lets cool, adds appropriate amount of ethanol, standing, Aspirate supernatant, remaining liquid filters, filtrate merges with supernatant, add 40% sodium hydroxide solution and regulate pH value to 8-8.5, stand, filter.Filtrate is concentrated into 1000ml.It is standby that Semen Armeniacae Amarum is configured to aqua armeniacae.By the appropriate distilled water diluting of above-mentioned concentrated solution, stirring evenly, add bitter almond water and Mel, polyoxyethylene sorbitan monoleate, sodium benzoate etc. is appropriate, adds water to full dose, with citron acid for adjusting pH value to 4.5-5.5, stirs evenly, and filters, and stands, fill, sterilizing, to obtain final product.Aqua armeniacae is prepared by two 519 pages " aqua armeniacae " items of " Chinese Pharmacopoeia " version in 1963.
Zhisoudingchuankoufuye evident in efficacy, but method for making is more complicated, adjusts pH value, adds the difficulty of quality control for twice.
Summary of the invention
First technical problem that the invention solves the problems that is to provide a kind of relieving cough, relieving asthma Chinese medicine composition.
The preparation method that another technical problem that the invention solves the problems that is to provide said medicine.
For achieving the above object, the present invention is by the following technical solutions:
A kind of relieving cough, relieving asthma Chinese medicine composition, its effective ingredient is made up of the raw material of following parts by weight: 1 part of Herba Ephedrae, Semen Armeniacae Amarum 1 part, 1 part of Radix Glycyrrhizae, 1 part of Gypsum Fibrosum.
Described effective ingredient adopts following method to prepare: weigh each raw material by proportioning raw materials, standby；Semen Armeniacae Amarum is ground into coarse powder, deoils, ethanol extraction 2-3 time being 60%-95% with the concentration of volume percent of 2-8 times amount, each 1-3 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.15-1.30, obtains concentrated solution A；Herba Ephedrae, Radix Glycyrrhizae, Gypsum Fibrosum are with 4-12 times amount water extraction 2-3 time, and each 1-3 hour, united extraction liquid, being concentrated under 50-60 DEG C of condition relative density was 1.20-1.35, obtains concentrated solution B；Concentrated solution A, B are mixed, dry, obtain dried object I；Dried object I, is effective ingredient.
Described effective ingredient adopts following method to prepare: weigh each raw material by proportioning raw materials, standby；Semen Armeniacae Amarum is ground into coarse powder, deoils, ethanol extraction 2-3 time being 70%-85% with the concentration of volume percent of 4-6 times amount, each 1-2 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.20-1.25, obtains concentrated solution A；Herba Ephedrae, Radix Glycyrrhizae, Gypsum Fibrosum are with 6-10 times amount water extraction 2 times, and each 1-2 hour, united extraction liquid, being concentrated under 50-60 DEG C of condition relative density was 1.25-1.30, obtains concentrated solution B；Concentrated solution A, B are mixed, dry, obtain dried object I；Dried object I, is effective ingredient.
Described effective ingredient adopts following method to prepare: weigh each raw material by proportioning raw materials, standby；Semen Armeniacae Amarum is ground into coarse powder, deoils, the ethanol extraction twice being 70% with concentration of volume percent, and first time 6 times amount are extracted 1.5 hours, and second time 4 times amount are extracted 1 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.20, obtains concentrated solution A；Herba Ephedrae, Radix Glycyrrhizae, parget water extract 2 times, and first time 8 times amount are extracted 2 hours, and second time 6 times amount are extracted 1.5 hours, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.25, obtains concentrated solution B；Concentrated solution A, B are mixed, dry, obtain dried object I；Dried object I, is effective ingredient.
Described Chinese medicine composition is possibly together with the acceptable adjuvant of pharmaceutics.
The acceptable adjuvant of described pharmaceutics is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and sodium sulfite.
The dosage form of described Chinese medicine composition is pill, tablet, capsule or oral liquid.The selection of dosage form and the consumption of adjuvant belong to prior art.
The preparation method of a kind of relieving cough, relieving asthma Chinese medicine composition, weighs 1 part of Herba Ephedrae, Semen Armeniacae Amarum 1 part, 1 part of Radix Glycyrrhizae, 1 part of Gypsum Fibrosum；Semen Armeniacae Amarum is ground into coarse powder, deoils, ethanol extraction 2-3 time being 60%-95% with the concentration of volume percent of 2-8 times amount, each 1-3 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.15-1.30, obtains concentrated solution A；Herba Ephedrae, Radix Glycyrrhizae, Gypsum Fibrosum are with 4-12 times amount water extraction 2-3 time, and each 1-3 hour, united extraction liquid, being concentrated under 50-60 DEG C of condition relative density was 1.20-1.35, obtains concentrated solution B；Concentrated solution A, B are mixed, dry, obtain dried object I；Dried object I, is effective ingredient.
Preferred method for making is: weigh each raw material by proportioning raw materials, standby；Semen Armeniacae Amarum is ground into coarse powder, deoils, ethanol extraction 2-3 time being 70%-85% with the concentration of volume percent of 4-6 times amount, each 1-2 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.20-1.25, obtains concentrated solution A；Herba Ephedrae, Radix Glycyrrhizae, Gypsum Fibrosum are with 6-10 times amount water extraction 2 times, and each 1-2 hour, united extraction liquid, being concentrated under 50-60 DEG C of condition relative density was 1.25-1.30, obtains concentrated solution B；Concentrated solution A, B are mixed, dry, obtain dried object I；Dried object I, is effective ingredient.
Most preferred method for making is: weigh each raw material by proportioning raw materials, standby；Semen Armeniacae Amarum is ground into coarse powder, deoils, the ethanol extraction twice being 70% with concentration of volume percent, and first time 6 times amount are extracted 1.5 hours, and second time 4 times amount are extracted 1 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.20, obtains concentrated solution A；Herba Ephedrae, Radix Glycyrrhizae, parget water extract 2 times, and first time 8 times amount are extracted 2 hours, and second time 6 times amount are extracted 1.5 hours, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.25, obtains concentrated solution B；Concentrated solution A, B are mixed, dry, obtain dried object I；Dried object I, is effective ingredient.
Chinese medicine composition involved by technical solution of the present invention and preparation thereof are respectively provided with good pungent cool to be led off, the function of clearing lung, relieving asthma.Can be used for exterior cold and interior heat, fever of the body is thirsty, cough with profuse sputum, dyspnea with rapid and short breath QI rising in reverse order, and chest and diaphragm is full vexed；Acute bronchitis is shown in above-mentioned patient.Results of animal shows, pharmaceutical composition prepared by present invention process compared with former dosage form, have more excellent reduce phlegm, antiinflammation.
The invention have the advantage that the present invention uses theory of Chinese medical science to analyze prescription composition, the result of study according to the physicochemical property of each flavour of a drug ingredient Yu pharmacological action, the preparation method that research obtains reasonable, stable effective ingredient.Adopt technical solution of the present invention, prepared pharmaceutical preparation stable and controllable for quality, that curative effect significantly improves compared with existing commercial dosage forms, patient's taking dose reduces, bioavailability improves, there is significant economic and social benefit.
Describe technical solution of the present invention by the following examples in detail, do not limit the practical range of the present invention with this.
Detailed description of the invention
Embodiment 1: prepare Chinese medicine extract
One. prescription:
Herba Ephedrae 100g Semen Armeniacae Amarum 100g Radix Glycyrrhizae 100g Gypsum Fibrosum 100g
Two. method for making:
Each raw material is weighed by proportioning raw materials, standby；Semen Armeniacae Amarum is ground into coarse powder, deoils, the ethanol extraction twice being 70% with concentration of volume percent, and first time 6 times amount are extracted 1.5 hours, and second time 4 times amount are extracted 1 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.20, obtains concentrated solution A；Herba Ephedrae, Radix Glycyrrhizae, parget water extract 2 times, and first time 8 times amount are extracted 2 hours, and second time 6 times amount are extracted 1.5 hours, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.25, obtains concentrated solution B；Concentrated solution A, B are mixed, dry, obtain dried object I；Dried object I, is effective ingredient.The amount of effective ingredient is 110g.
Embodiment 2: prepare Chinese medicine extract
One. prescription:
Herba Ephedrae 500g Semen Armeniacae Amarum 500g Radix Glycyrrhizae 500g Gypsum Fibrosum 500g
Two. method for making:
Each raw material is weighed by proportioning raw materials, standby；Semen Armeniacae Amarum is ground into coarse powder, deoils, and with concentration of volume percent for 85% ethanol extraction twice, first time 6 times amount are extracted 1.5 hours, and second time 4 times amount are extracted 1 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.15, obtains concentrated solution A；Herba Ephedrae, Radix Glycyrrhizae, parget water extract 2 times, and first time 10 times amount are extracted 2 hours, and second time 8 times amount are extracted 1 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.25, obtains concentrated solution B；Concentrated solution A, B are mixed, dry, obtain dried object I；Dried object I, is effective ingredient.The amount of effective ingredient is 380g.
Embodiment 3: prepare Chinese medicine extract
One. prescription:
Herba Ephedrae 500g Semen Armeniacae Amarum 500g Radix Glycyrrhizae 500g Gypsum Fibrosum 500g
Two. method for making:
Each raw material is weighed by proportioning raw materials, standby；Semen Armeniacae Amarum is ground into coarse powder, deoils, the ethanol extraction 3 times being 60% with the concentration of volume percent of 2-8 times amount, each 1 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.30, obtains concentrated solution A；Herba Ephedrae, Radix Glycyrrhizae, Gypsum Fibrosum are with 4 times amount water extraction 3 times, and each 3 hours, united extraction liquid, being concentrated under 50-60 DEG C of condition relative density was 1.35, obtains concentrated solution B；Concentrated solution A, B are mixed, dry, obtain dried object I；Dried object I, is effective ingredient.
Embodiment 4: prepare Chinese medicine extract
One. prescription:
Herba Ephedrae 500g Semen Armeniacae Amarum 500g Radix Glycyrrhizae 500g Gypsum Fibrosum 500g
Two. method for making:
Each raw material is weighed by proportioning raw materials, standby；Semen Armeniacae Amarum is ground into coarse powder, deoils, the ethanol extraction 2 times being 95% with the concentration of volume percent of 2-8 times amount, each 1 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.15, obtains concentrated solution A；Herba Ephedrae, Radix Glycyrrhizae, Gypsum Fibrosum are with 12 times amount water extraction 2 times, and each 1 hour, united extraction liquid, being concentrated under 50-60 DEG C of condition relative density was 1.20, obtains concentrated solution B；Concentrated solution A, B are mixed, dry, obtain dried object I；Dried object I, is effective ingredient.
Embodiment 5: prepare Chinese medicine extract
One. prescription:
Herba Ephedrae 500g Semen Armeniacae Amarum 500g Radix Glycyrrhizae 500g Gypsum Fibrosum 500g
Two. method for making:
Each raw material is weighed by proportioning raw materials, standby；Semen Armeniacae Amarum is ground into coarse powder, deoils, the ethanol extraction 2 times being 70% with the concentration of volume percent of 6 times amount, each 1.5 hours, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.20, obtains concentrated solution A；Herba Ephedrae, Radix Glycyrrhizae, Gypsum Fibrosum are with 6 times amount water extraction 2 times, and each 1.5 hours, united extraction liquid, being concentrated under 50-60 DEG C of condition relative density was 1.25, obtains concentrated solution B；Concentrated solution A, B are mixed, dry, obtain dried object I；Dried object I, is effective ingredient.
Embodiment 6: prepare Chinese medicine extract
One. prescription:
Herba Ephedrae 500g Semen Armeniacae Amarum 500g Radix Glycyrrhizae 500g Gypsum Fibrosum 500g
Two. method for making:
Each raw material is weighed by proportioning raw materials, standby；Semen Armeniacae Amarum is ground into coarse powder, deoils, the ethanol extraction 2 times being 85% with the concentration of volume percent of 6 times amount, each 2 hours, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.25, obtains concentrated solution A；Herba Ephedrae, Radix Glycyrrhizae, Gypsum Fibrosum are with 10 times amount water extraction 2 times, and each 2 hours, united extraction liquid, being concentrated under 50-60 DEG C of condition relative density was 1.30, obtains concentrated solution B；Concentrated solution A, B are mixed, dry, obtain dried object I；Dried object I, is effective ingredient.
Embodiment 7: prepare Chinese medicine extract
One. prescription:
Herba Ephedrae 500g Semen Armeniacae Amarum 500g Radix Glycyrrhizae 500g Gypsum Fibrosum 500g
Two. method for making:
Each raw material is weighed by proportioning raw materials, standby；Semen Armeniacae Amarum is ground into coarse powder, deoils, the ethanol extraction 3 times being 75% with the concentration of volume percent of 4-6 times amount, each 2 hours, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.23, obtains concentrated solution A；Herba Ephedrae, Radix Glycyrrhizae, Gypsum Fibrosum are with 8 times amount water extraction 2 times, and each 2 hours, united extraction liquid, being concentrated under 50-60 DEG C of condition relative density was 1.28, obtains concentrated solution B；Concentrated solution A, B are mixed, dry, obtain dried object I；Dried object I, is effective ingredient.
Embodiment 8: prepare tablet
The effective ingredient 110g that embodiment 1 obtains, adds microcrystalline Cellulose 80g, cross-linked pvp 10g, tabletting, obtains tablet, and every is 0.40g.
Embodiment 9: prepare capsule
The effective ingredient 380g that embodiment 2 obtains, adds starch 120g, granulates, and encapsulating capsule obtains capsule, every weight 0.35g.
Embodiment 10: Zhisoudingchuankoufuye pharmacological evaluation
One. test material
1. laboratory animal:
ICR mice, male, SPF level, Beijing Vital River Experimental Animals Technology Co., Ltd. provides, animal credit number: SCXK (capital) 2012-0001.
2. medicine and reagent:
Zhisoudingchuankoufuye, relieving cough, relieving asthma extract (preparing by embodiment 1 method), Tianjin Zhongxin Pharmaceutical Group Co., Ltd..
Ammonium chloride, Tianjin Kermel Chemical Reagent Co., Ltd..
Sodium bicarbonate, Tianjin Kermel Chemical Reagent Co., Ltd..
Sodium hydroxide, Tianjin Kermel Chemical Reagent Co., Ltd..
Phenol red (Phenolred), Amresco.
Dimethylbenzene, Tianjin Kermel Chemical Reagent Co., Ltd..
Aspirin effervescent tablets, AstraZeneca pharmaceutical Co. Ltd.
3. instrument:
Analytical balance, SartoriusBP2111D type, Sartorius AG.
Semi-automatic biochemical analyzer, KHBL-3180, Shanghai Ke Hua pilot system company limited.
Centrifuge, Contifuge17RS, HeraeusSEPATECH.
Miniature whirlpool mixed instrument, XW-80A, the auspicious chemical reagent company limited in Tianjin one.
Ear is swollen beats ear device, YLS-Q4, Jinan Yi Yan development in science and technology company limited.
Two. method and result
1. the phenol red expectorant test of mice
Select healthy without hindering ICR mice, all male, by body weight random packet, often group 16, it may be assumed that matched group, positive controls (ammonium chloride 1g/kg), Zhisoudingchuankoufuye group (4g crude drug/kg), relieving cough, relieving asthma extract group (2,4,8g crude drug/kg), by body weight gastric infusion respectively, administration volume is 20ml/kg, continuous 7 days, every day 1 time, positive drug is in experimental day gastric infusion 1 time, and matched group gives the pure water of same volume.Last is administered the previous day, and more than water 12h is can't help in fasting.It is administered latter 30 minutes in last, the phenol red 20ml/kg body weight of lumbar injection 2.5%.After injecting phenol red half an hour, animal is put to death in dislocation.Peel off trachea surrounding tissue, cut from thyroid cartilage down to one section of trachea of trachea bifurcation, put in the centrifuge tube filling 1ml normal saline, add the sodium hydroxide of 0.1ml1mol/L, miniature whirlpool mixed instrument fully vibrates, Contifuge17RS centrifuge 3000 leaves heart 15min, supernatant solution is sucked in test tube, in wavelength 546nm colorimetric, measure A value, (phenolsulfonphthalein standards 0.25 of concentration known is taken according to pre-rendered phenol red standard curve, 0.5, 1, 2, 4, 8ug/ml, process by same procedure, measure OD value, and drawing standard regression curve), calculate every phenol red excretion of mice trachea.Adopt SPSS software to carry out one factor analysis of variance and data are carried out statistical procedures.Result of the test refers to table 1.
PSP increment rate %=(administration group phenols contents matched group phenols contents)/matched group phenols contents * 100%
The impact on mice trachea section PSP of the table 1 relieving cough, relieving asthma extract
Compared with matched group, * P < 0.05；**P<0.01
Result shows, relieving cough, relieving asthma extract 2,4, all can promotion mice PSP in various degree under 8g crude drug/kg dosage, there is significant dose-effect relationship, illustrate relieving cough, relieving asthma extract 2,4, there is certain resolve phlegm effect under 8g crude drug/kg dosage, and the relieving cough, relieving asthma extract resolve phlegm effect under 4g crude drug/kg dosage is better than the Zhisoudingchuankoufuye under same dosage.
2. mouse auricle swelling test
Select healthy without hindering ICR mice, all male, by body weight random packet, often group 12, it may be assumed that matched group, positive controls (aspirin 0.3g/kg), Zhisoudingchuankoufuye group (4g crude drug/kg), relieving cough, relieving asthma extract group (2,4,8g crude drug/kg).By body weight respectively continuous 7 days of gastric infusion, aspirin is in test gastric infusion on the same day 1 time, and administration volume is 20ml/kg, and matched group gives the pure water of same volume.Within latter 1 hour, causing inflammation in last administration, auris dextra two sides is uniformly coated with 100% dimethylbenzene 10 μ l/ face, only amounts to 20 μ l/, and left ear is comparison.Put to death mice after causing scorching 45min, cut two ears along auricle baseline, make ear device lay round auricle at the two same positions of ear respectively with 8mm diameter ear is swollen, after beating ear, claim weight in wet base with analytical balance as early as possible.Two ear weight difference represent degree of inflammation as swelling, and calculate inflammation suppression ratio.Adopt SPSS software to carry out one factor analysis of variance and data are carried out statistical procedures.Result of the test refers to table 2.
The left auricle weight mg of swelling mg=auris dextra sheet weight mg-.
Inflammation suppression ratio %=[(matched group swelling-administration group swelling)/matched group swelling] * 100%.
The impact on mice auricle swelling of the table 2 relieving cough, relieving asthma extract
Compared with matched group, * P < 0.05；**P<0.01；
Result shows, relieving cough, relieving asthma extract 2,4, all can suppress mice under 8g crude drug/kg dosage in various degree and wide swelling, there is significant dose-effect relationship, illustrate relieving cough, relieving asthma extract 2,4, there is certain antiinflammatory action under 8g crude drug/kg dosage, and the relieving cough, relieving asthma extract resolve phlegm effect under 4g crude drug/kg dosage is better than the Zhisoudingchuankoufuye under same dosage.
Claims (10)
1. a relieving cough, relieving asthma Chinese medicine composition, it is characterised in that: its effective ingredient is made up of the raw material of following parts by weight: 1 part of Herba Ephedrae, Semen Armeniacae Amarum 1 part, 1 part of Radix Glycyrrhizae, 1 part of Gypsum Fibrosum.
2. a kind of relieving cough, relieving asthma Chinese medicine composition according to claim 1, it is characterised in that: described effective ingredient adopts following method to prepare: weigh each raw material by proportioning raw materials, standby；Semen Armeniacae Amarum is ground into coarse powder, deoils, ethanol extraction 2-3 time being 60%-95% with the concentration of volume percent of 2-8 times amount, each 1-3 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.15-1.30, obtains concentrated solution A；Herba Ephedrae, Radix Glycyrrhizae, Gypsum Fibrosum are with 4-12 times amount water extraction 2-3 time, and each 1-3 hour, united extraction liquid, being concentrated under 50-60 DEG C of condition relative density was 1.20-1.35, obtains concentrated solution B；Concentrated solution B, C are mixed, dry, obtain dried object I；Dried object I, is effective ingredient.
3. a kind of relieving cough, relieving asthma Chinese medicine composition according to claim 2, it is characterised in that: described effective ingredient adopts following method to prepare: weigh each raw material by proportioning raw materials, standby；Semen Armeniacae Amarum is ground into coarse powder, deoils, ethanol extraction 2-3 time being 70%-85% with the concentration of volume percent of 4-6 times amount, each 1-2 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.20-1.25, obtains concentrated solution A；Herba Ephedrae, Radix Glycyrrhizae, Gypsum Fibrosum are with 6-10 times amount water extraction 2 times, and each 1-2 hour, united extraction liquid, being concentrated under 50-60 DEG C of condition relative density was 1.25-1.30, obtains concentrated solution B；Concentrated solution B, C are mixed, dry, obtain dried object I；Dried object I, is effective ingredient.
4. a kind of relieving cough, relieving asthma Chinese medicine composition according to claim 3, it is characterised in that: described effective ingredient adopts following method to prepare: weigh each raw material by proportioning raw materials, standby；Semen Armeniacae Amarum is ground into coarse powder, deoils, the ethanol extraction twice being 70% with concentration of volume percent, and first time 6 times amount are extracted 1.5 hours, and second time 4 times amount are extracted 1 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.20, obtains concentrated solution A；Herba Ephedrae, Radix Glycyrrhizae, parget water extract 2 times, and first time 8 times amount are extracted 2 hours, and second time 6 times amount are extracted 1.5 hours, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.25, obtains concentrated solution B；Concentrated solution B, C are mixed, dry, obtain dried object I；Dried object I, is effective ingredient.
5. a kind of relieving cough, relieving asthma Chinese medicine composition in any of the one of Claims 1-4, it is characterised in that: described Chinese medicine composition is possibly together with the acceptable adjuvant of pharmaceutics.
6. a kind of relieving cough, relieving asthma Chinese medicine composition according to claim 5, it is characterised in that: the acceptable adjuvant of described pharmaceutics is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and sodium sulfite.
7. a kind of relieving cough, relieving asthma Chinese medicine composition according to claim 6, it is characterised in that: the dosage form of described Chinese medicine composition is pill, tablet, capsule or oral liquid.
8. the preparation method of a relieving cough, relieving asthma Chinese medicine composition, it is characterised in that comprise the steps: to weigh 1 part of Herba Ephedrae, Semen Armeniacae Amarum 1 part, 1 part of Radix Glycyrrhizae, 1 part of Gypsum Fibrosum；Semen Armeniacae Amarum is ground into coarse powder, deoils, ethanol extraction 2-3 time being 60%-95% with the concentration of volume percent of 2-8 times amount, each 1-3 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.15-1.30, obtains concentrated solution A；Herba Ephedrae, Radix Glycyrrhizae, Gypsum Fibrosum are with 4-12 times amount water extraction 2-3 time, and each 1-3 hour, united extraction liquid, being concentrated under 50-60 DEG C of condition relative density was 1.20-1.35, obtains concentrated solution B；Concentrated solution B, C are mixed, dry, obtain dried object I；Dried object I, is effective ingredient.
9. the preparation method of a kind of relieving cough, relieving asthma Chinese medicine composition according to claim 8, it is characterised in that: weigh each raw material by proportioning raw materials, standby；Semen Armeniacae Amarum is ground into coarse powder, deoils, ethanol extraction 2-3 time being 70%-85% with the concentration of volume percent of 4-6 times amount, each 1-2 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.20-1.25, obtains concentrated solution A；Herba Ephedrae, Radix Glycyrrhizae, Gypsum Fibrosum are with 6-10 times amount water extraction 2 times, and each 1-2 hour, united extraction liquid, being concentrated under 50-60 DEG C of condition relative density was 1.25-1.30, obtains concentrated solution B；Concentrated solution B, C are mixed, dry, obtain dried object I；Dried object I, is effective ingredient.
10. the preparation method of a kind of relieving cough, relieving asthma Chinese medicine composition according to claim 9, it is characterised in that: weigh each raw material by proportioning raw materials, standby；Semen Armeniacae Amarum is ground into coarse powder, deoils, the ethanol extraction twice being 70% with concentration of volume percent, and first time 6 times amount are extracted 1.5 hours, and second time 4 times amount are extracted 1 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.20, obtains concentrated solution A；Herba Ephedrae, Radix Glycyrrhizae, parget water extract 2 times, and first time 8 times amount are extracted 2 hours, and second time 6 times amount are extracted 1.5 hours, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.25, obtains concentrated solution B；Concentrated solution B, C are mixed, dry, obtain dried object I；Dried object I, is effective ingredient.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| CN103800478A (en) * | 2012-11-14 | 2014-05-21 | 沈锋艳 | Preparation method of ephedra-almond cough-relieving sugared pill |
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