CN105796651A - Composition capable of reducing blood glucose and preparation method - Google Patents
Composition capable of reducing blood glucose and preparation method Download PDFInfo
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- CN105796651A CN105796651A CN201410854891.7A CN201410854891A CN105796651A CN 105796651 A CN105796651 A CN 105796651A CN 201410854891 A CN201410854891 A CN 201410854891A CN 105796651 A CN105796651 A CN 105796651A
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Abstract
The invention discloses a composition capable of reducing blood glucose and a preparation method, belonging to the field of health foods. The composition capable of reducing blood glucose is prepared from folium mori, American ginseng and the like. The composition has the advantages that a formula is reasonable and concise, the dosage is small, the efficacies of reducing the blood glucose and regulating the glucose metabolic balance of the organism are both considered, the blood glucose reducing process is slow, and the effects are remarkable.
Description
Technical field
The present invention relates to a kind of compound for reducing blood suger and preparation method, belong to field of health care food.
Background technology
Diabetes have become global healthcare problem, there is no the effective ways curing diabetes at present, so controlling blood sugar level is prevention and the key alleviating diabetes harm.Diabetes are a kind of chronic, lifelong disease, need to control blood glucose throughout one's life, this be accomplished by Related product safely, effectively, be suitable for long-term taking.Owing to present diabetics is numerous, the exploitation for assistant hypoglycemia healthcare food has been provided with significantly high maturity.The health food being currently used for regulating blood glucose mainly has following a few class:
Containing flavone, alkaloids article: the blood sugar concentration of diabetics can be reduced, improve the bioactive ingredients of its symptom.As: Folium Mori, propolis, Radix Et Rhizoma Fagopyri Tatarici etc..
Containing saponins article: regulate insulin secretion, promote carbohydrate metabolism and lipid metabolism.Wherein represent and have Radix Panacis Quinquefolii, japanese angelica tree, Semen sojae atricolor, Fructus Momordicae, Punica granatum L., Poria, Herba Spinaciae etc..
Containing polysaccharide article: have now been found that various plants polysaccharide can reduce greatly blood glucose, modal such as polygonatum polysaccharide, ganoderan, Tea Polysaccharides, laminarin, SKGM, squash polyoses.
Current blood sugar lowering class health food mostly is above-mentioned medicinal substances extract and forms alone or in combination, and dose is big, and hypoglycemic effect is inconspicuous.
Summary of the invention
First technical problem that the invention solves the problems that is to provide a kind of compound for reducing blood suger.
The preparation method that another technical problem that the invention solves the problems that is to provide above-mentioned compound for reducing blood suger.
For achieving the above object, the present invention is by the following technical solutions:
A kind of compound for reducing blood suger, active component is made up of the raw material of following parts by weight: Radix Panacis Quinquefolii 1 part-30 parts, 1 part-30 parts of Folium Mori, L-arabinose 1 part-100 parts.
Described active component is preferably made up of the raw material of following parts by weight: Radix Panacis Quinquefolii 1 part-10 parts, Folium Mori 1-part-10 parts, L-arabinose 20 parts-70 parts.
Described active component is most preferably made up of the raw material of following parts by weight: Radix Panacis Quinquefolii 20 parts, 20 parts of Folium Mori, L-arabinose 50 parts.
Radix Panacis Quinquefolii, also known as panacis quinquefolii radix, Radix Panacis Quinquefolii, has boosting qi and nourishing yin, effect of clearing away heat and promoting production of body fluid, and for deficiency of vital energy yin deficiency, interior-heat, cough with asthma expectorant blood, deficiency-heat is tired of tired, quenches one's thirst, dryness of the mouth and throat.Radix Panacis Quinquefolii has the effect of resisting fatigue, antioxidation, suppression platelet aggregation, reduction blood coagulability, and Radix Panacis Quinquefolii can regulate insulin secretion, promote carbohydrate metabolism and lipid metabolism, affects carbohydate metabolism from many aspects, plays the effect of collaborative assisting in reducing blood sugar.
Folium Mori are the dried leaves of Moraceae (Moraceae) plant Mulberry (MorusalbaL), bitter in the mouth, sweet, cold in nature, return lung, Liver Channel, have dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, effect of liver heat removing and eyesight improving.
L-arabinose, also known as Arabinose, pectose, is a kind of aldopentose, it is possible to affecting the activity of human body hydrolysis disaccharidase, stoping excessive sucrose to be taken in, thus reducing blood glucose effect.It can suppress the enzyme of hydrolysis disaccharidase, therefore suppresses the blood glucose caused because taking in sucrose (resolve into glucose and fructose under the effect of small intestinal saccharase and absorbed) to raise.
In the present invention, L-arabinose suppresses the absorption of sucrose, and Radix Panacis Quinquefolii can regulate insulin secretion, promote carbohydrate metabolism and lipid metabolism.Folium Mori have suppression blood glucose to rise, reduce cholesterol, suppress body fat accumulation, maintain and salubrious effect, and several raw materials cooperate, comprehensive reduction blood sugar concentration.
The present invention not only prescription is simplified, and for the characteristic of raw medicinal material, by the extraction process of science, obtains the active component with definite curative effect.
Described active component is adopted and is prepared with the following method: weigh each raw material by proportioning raw materials, standby；Radix Panacis Quinquefolii 4-10 times amount concentration of volume percent is ethanol extraction 1-3 time of 30%-90%, each 1-4 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.05-1.30, obtains concentrated solution A；Folium Mori soak 1-3 time with the 4-12 times amount water temperature of 40-90 DEG C, each 1-3 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.05-1.30, obtains concentrated solution B；Concentrated solution A, B are separately dried, and obtain dried object I, II；Dried object I, II are mixed homogeneously with L-arabinose, obtain dried object III；Dried object III, is active component.
Described active component preferably employs following method to be prepared: weigh each raw material by proportioning raw materials, standby；Radix Panacis Quinquefolii 6-8 times amount concentration of volume percent is ethanol extraction 2-3 time of 40%-80%, each 1.5-2 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.10-1.20, obtains concentrated solution A；Folium Mori soak 2-3 time with the 6-10 times amount water temperature of 60-80 DEG C, each 1-2 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.10-1.20, obtains concentrated solution B；Concentrated solution A, B are separately dried, and obtain dried object I, II；Dried object I, II are mixed homogeneously with L-arabinose, obtain dried object III；Dried object III, is active component.
Described compound for reducing blood suger is possibly together with adjuvant.
Described adjuvant is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid, sorbitol and sodium sulfite.
Described compound for reducing blood suger is granule, powder, tablet, capsule or oral liquid.
A kind of preparation method of compound for reducing blood suger, each raw material is weighed by proportioning raw materials, standby, wherein Radix Panacis Quinquefolii 1 part-30 parts, 1 part-30 parts of Folium Mori, L-arabinose 1 part-100 parts, it is preferable that Radix Panacis Quinquefolii 1 part-10 parts, Folium Mori 1-part-10 parts, L-arabinose 20 parts-70 parts, most preferably Radix Panacis Quinquefolii 20 parts, 20 parts of Folium Mori, L-arabinose 50 parts；Radix Panacis Quinquefolii 4-10 times amount concentration of volume percent is ethanol extraction 1-3 time of 30%-90%, each 1-4 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.05-1.30, obtains concentrated solution A；Folium Mori soak 1-3 time with the 4-12 times amount water temperature of 40-90 DEG C, each 1-3 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.05-1.30, obtains concentrated solution B；Concentrated solution A, B are separately dried, and obtain dried object I, II；Dried object I, II are mixed homogeneously with L-arabinose, obtain dried object III；Dried object III, is active component.
Preferred preparation method is: Radix Panacis Quinquefolii 6-8 times amount concentration of volume percent is ethanol extraction 2-3 time of 40%-80%, each 1.5-2 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.10-1.20, obtains concentrated solution A；Folium Mori soak 2-3 time with the 6-10 times amount water temperature of 60-80 DEG C, each 1-2 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.10-1.20, obtains concentrated solution B；Concentrated solution A, B are separately dried, and obtain dried object I, II；Dried object I, II are mixed homogeneously with L-arabinose, obtain dried object III；Dried object III, is active component.
Compound for reducing blood suger involved by technical solution of the present invention and preparation thereof are respectively provided with and good drop hypoglycemic effect.
The invention have the advantage that reasonable recipe, simplify, dose is little, takes into account blood sugar lowering and regulates body carbohydrate metabolism balance, and blood sugar lowering is mild, and effect is notable.
Describe technical solution of the present invention by the following examples in detail, do not limit the practical range of the present invention with this.
Detailed description of the invention
Embodiment 1:
One. prescription:
Radix Panacis Quinquefolii 200g, Folium Mori 200g, L-arabinose 500g
Two. method for making:
Each raw material is weighed by proportioning raw materials, standby；The Radix Panacis Quinquefolii ethanol extraction that 8 times amount concentration of volume percent are 70% 3 times, each 2 hours, united extraction liquid, being concentrated under 50-60 DEG C of condition relative density was 1.20, obtains concentrated solution A；Folium Mori soak 2 times with 80 DEG C of water temperatures, and first time adds 10 times amount water extraction 2 hours, and second time adds 8 times amount water extraction 2 hours, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.20, obtains concentrated solution B；Concentrated solution A, B are separately dried, and obtain dried object I, II；Dried object I, II are mixed homogeneously with L-arabinose, obtain dried object III；Dried object III, is active component.Active component weight 620g.
Embodiment 2:
One. prescription:
Radix Panacis Quinquefolii 400g, Folium Mori 400g, L-arabinose 1000g
Two. method for making:
Each raw material is weighed by proportioning raw materials, standby；Radix Panacis Quinquefolii concentration of volume percent is the ethanol extraction 2 times of 70%, and Radix Panacis Quinquefolii extracts 2 times, and first time adds 70% ethanol 8 times amount and extracts 2 hours, second time adds 70% ethanol 6 times amount and extracts 1.5 hours, united extraction liquid, being concentrated under 50-60 DEG C of condition relative density is 1.10, obtains concentrated solution A；Folium Mori soak 3 times with the water temperature of 60 DEG C, and first time adds 10 times amount water extraction 2 hours, and second and third time 8 times amount that add water are extracted 1 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.10, obtains concentrated solution B；Concentrated solution A, B are separately dried, and obtain dried object I, II；Dried object I, II are mixed homogeneously with L-arabinose, obtain dried object III；Dried object III, is active component.Active component weight 1200g.
Embodiment 3:
One. prescription:
Radix Panacis Quinquefolii 100g, Folium Mori 100g, L-arabinose 100g.
Two. method for making:
Each raw material is weighed by proportioning raw materials, standby；The Radix Panacis Quinquefolii ethanol extraction that 4 times amount concentration of volume percent are 90% 3 times, each 1 hour, united extraction liquid, being concentrated under 50-60 DEG C of condition relative density was 1.05, obtains concentrated solution A；Folium Mori soak 1 time with the 4 times amount water temperatures of 90 DEG C, 3 hours, and being concentrated under 50-60 DEG C of condition relative density is 1.05, obtains concentrated solution B；Concentrated solution A, B are separately dried, and obtain dried object I, II；Dried object I, II are mixed homogeneously with L-arabinose, obtain dried object III；Dried object III, is active component.
Embodiment 4:
One. prescription:
Radix Panacis Quinquefolii 30g, Folium Mori 30g, L-arabinose 100g.
Two. method for making:
Each raw material is weighed by proportioning raw materials, standby；The Radix Panacis Quinquefolii ethanol extraction that 10 times amount concentration of volume percent are 30% 3 times, each 1 hour, united extraction liquid, being concentrated under 50-60 DEG C of condition relative density was 1.30, obtains concentrated solution A；Folium Mori soak 3 times with the 12 times amount water temperatures of 40 DEG C, each 1 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.30, obtains concentrated solution B；Concentrated solution A, B are separately dried, and obtain dried object I, II；Dried object I, II are mixed homogeneously with L-arabinose, obtain dried object III；Dried object III, is active component.
Embodiment 5:
One. prescription:
Radix Panacis Quinquefolii 10g, Folium Mori 10g, L-arabinose 200g.
Two. method for making:
Each raw material is weighed by proportioning raw materials, standby；Radix Panacis Quinquefolii 4-10 times amount concentration of volume percent is the ethanol extraction 1 time of 50%, 4 hours, and being concentrated under 50-60 DEG C of condition relative density is 1.20, obtains concentrated solution A；Folium Mori soak 2 times with the 12 times amount water temperatures of 50 DEG C, each 2.5 hours, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.20, obtains concentrated solution B；Concentrated solution A, B are separately dried, and obtain dried object I, II；Dried object I, II are mixed homogeneously with L-arabinose, obtain dried object III；Dried object III, is active component.
Embodiment 6:
One. prescription:
Radix Panacis Quinquefolii 100g, Folium Mori 100g, L-arabinose 700g.
Two. method for making:
The Radix Panacis Quinquefolii ethanol extraction that 6 times amount concentration of volume percent are 40% 3 times, each 2 hours, united extraction liquid, being concentrated under 50-60 DEG C of condition relative density was 1.10, obtains concentrated solution A；Folium Mori soak 3 times with the 6 times amount water temperatures of 60 DEG C, each 2 hours, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.10, obtains concentrated solution B；Concentrated solution A, B are separately dried, and obtain dried object I, II；Dried object I, II are mixed homogeneously with L-arabinose, obtain dried object III；Dried object III, is active component.
Embodiment 7:
One. prescription:
Radix Panacis Quinquefolii 50g, Folium Mori 50g, L-arabinose 400g.
Two. method for making:
The Radix Panacis Quinquefolii ethanol extraction that 8 times amount concentration of volume percent are 80% 2 times, each 1.5 hours, united extraction liquid, being concentrated under 50-60 DEG C of condition relative density was 1.25, obtains concentrated solution A；Folium Mori soak 3 times with the 10 times amount water temperatures of 80 DEG C, each 2 hours, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.15, obtains concentrated solution B；Concentrated solution A, B are separately dried, and obtain dried object I, II；Dried object I, II are mixed homogeneously with L-arabinose, obtain dried object III；Dried object III, is active component.
Embodiment 8: prepare Jiantang Granule
The active component 620g that embodiment 1 obtains, adds sorbitol 20g, granulates, obtains granule, every packed 2g.
Embodiment 9: prepare blood sugar lowering tablet
Embodiment 2 obtains active component 1200g, granulates, and tabletting obtains tablet, every tablet weight 2g.
Embodiment 10: pharmacological evaluation
1. test material
1.1 laboratory animals:
ICR mice, male, SPF level, Beijing Vital River Experimental Animals Technology Co., Ltd. provides.
ZDF rat, male, SPF level, Beijing Vital River Experimental Animals Technology Co., Ltd. provides.
1.2 medicines and reagent:
Blood sugar lowering extract, prepares by embodiment 1, Zhongxin Innova Laboratories.
Sucrose, Tianjin Kermel Chemical Reagent Co., Ltd..
L-arabinose, Tang Chuan bio tech ltd.
1.3 instruments:
Germany Roche (ROCHE) Luo Kang is remarkable type blood glucose meter and supporting Test paper entirely.
2. method and result
2.1 impacts that high glucose and high fat fed foster mice sucrose carbohydrate tolerance
Select healthy without hindering ICR mice, all male, feed high glucose and high fat feedstuff (formula: basestocks 60%, Adeps Sus domestica 10%, sucrose 10%, egg 10%, milk powder 5%, cholesterol 3%, Oleum sesami 2%), continuous 4 weeks.Tail vein blood, uses Roche blood glucose meter to measure blood glucose value, is 5 groups by blood glucose value equilibrium, often group 12, that is: matched group, L-arabinose group (3g/kg), blood sugar lowering extract (1.5,3,6g crude drug/kg) group, by body weight gastric infusion respectively, matched group gives equal-volume pure water, administration volume is 20ml/kg, continuous 3 weeks, and last is administered latter 1 hour, equal gavage sucrose solution (3g/kg), measures 0,0.5,2 hours blood glucose values.Adopt SPSS software to carry out one factor analysis of variance and data are carried out statistical procedures.Result of the test refers to table 1.
High glucose and high fat is fed the impact of mice sucrose carbohydrate tolerance by table 1 blood sugar lowering extract
Compared with matched group, * P < 0.05；**P<0.01
It is shown that 1.5g crude drug/kg and above dosage blood sugar lowering extract can significantly inhibit Mouse oral sucrose after the increasing rapidly of blood glucose value, present significant dose-effect relationship trend.Prompting blood sugar lowering extract can pass through effectively to suppress the absorption of sucrose in high-carbonhydrate diet, reduces the pharmacological action of blood glucose.
2.2 impacts on Bb Wistar Rats With Spontaneous Diabetes (ZDF rat) blood glucose
Select ZDF rat, all male, feeding high lipid food (formula: basestocks 88%, refined lard 10%, cholesterol 2%).Tail vein blood, use Roche blood glucose meter to measure blood glucose value, be 5 groups by blood glucose value equilibrium, often group 10, that is: matched group, L-arabinose group, blood sugar lowering extract (1.5,3,6g crude drug/kg) group, by body weight gastric infusion respectively, matched group gives equal-volume pure water, administration volume is 10ml/kg, continuous 4 weeks, last measured blood glucose value after being administered latter 1 hour again.Adopt SPSS software to carry out one factor analysis of variance and data are carried out statistical procedures.Result of the test refers to table 2.
The impact on ZUCKER rat blood sugar of the table 2 blood sugar lowering extract
Compared with matched group, * P < 0.05；**P<0.01
It is shown that 3g crude drug/kg and above dosage extract can significantly reduce the blood glucose value of Bb Wistar Rats With Spontaneous Diabetes, and present significant dose-effect relationship trend.Prompting blood sugar lowering extract has certain pharmacological action reducing by II diabetes glucose value.
Claims (10)
1. a compound for reducing blood suger, it is characterised in that active component is made up of the raw material of following parts by weight: Radix Panacis Quinquefolii 1 part-30 parts, 1 part-30 parts of Folium Mori, L-arabinose 1 part-100 parts.
2. a kind of compound for reducing blood suger according to claim 1, it is characterised in that active component is made up of the raw material of following parts by weight: Radix Panacis Quinquefolii 1 part-10 parts, Folium Mori 1-part-10 parts, L-arabinose 20 parts-70 parts.
3. a kind of compound for reducing blood suger according to claim 2, it is characterised in that active component is made up of the raw material of following parts by weight: Radix Panacis Quinquefolii 20 parts, 20 parts of Folium Mori, L-arabinose 50 parts.
4. a kind of compound for reducing blood suger in any of the one of claim 1-3, it is characterised in that: described active component is adopted and is prepared with the following method: weigh each raw material by proportioning raw materials, standby；Radix Panacis Quinquefolii 4-10 times amount concentration of volume percent is ethanol extraction 1-3 time of 30%-90%, each 1-4 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.05-1.30, obtains concentrated solution A；Folium Mori soak 1-3 time with the 4-12 times amount water temperature of 40-90 DEG C, each 1-3 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.05-1.30, obtains concentrated solution B；Concentrated solution A, B are separately dried, and obtain dried object I, II；Dried object I, II are mixed homogeneously with L-arabinose, obtain dried object III；Dried object III, is active component.
5. a kind of compound for reducing blood suger according to claim 4, it is characterised in that: described active component is adopted and is prepared with the following method: weigh each raw material by proportioning raw materials, standby；Radix Panacis Quinquefolii 6-8 times amount concentration of volume percent is ethanol extraction 2-3 time of 40%-80%, each 1.5-2 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.10-1.20, obtains concentrated solution A；Folium Mori soak 2-3 time with the 6-10 times amount water temperature of 60-80 DEG C, each 1-2 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.10-1.20, obtains concentrated solution B；Concentrated solution A, B are separately dried, and obtain dried object I, II；Dried object I, II are mixed homogeneously with L-arabinose, obtain dried object III；Dried object III, is active component.
6. a kind of compound for reducing blood suger in any of the one of claim 1-4, it is characterised in that: described compound for reducing blood suger is possibly together with adjuvant.
7. a kind of compound for reducing blood suger according to claim 6, it is characterised in that: described adjuvant is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid, sorbitol and sodium sulfite.
8. a kind of compound for reducing blood suger according to claim 6, it is characterised in that: described compound for reducing blood suger is granule, powder, tablet, capsule or oral liquid.
9. the preparation method of the compound for reducing blood suger in any of the one of claim 1-3, it is characterised in that: weigh each raw material by proportioning raw materials, standby；Radix Panacis Quinquefolii 4-10 times amount concentration of volume percent is ethanol extraction 1-3 time of 30%-90%, each 1-4 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.05-1.30, obtains concentrated solution A；Folium Mori soak 1-3 time with the 4-12 times amount water temperature of 40-90 DEG C, each 1-3 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.05-1.30, obtains concentrated solution B；Concentrated solution A, B are separately dried, and obtain dried object I, II；Dried object I, II are mixed homogeneously with L-arabinose, obtain dried object III；Dried object III, is active component.
10. the preparation method of compound for reducing blood suger according to claim 9, it is characterised in that: weigh each raw material by proportioning raw materials, standby；Radix Panacis Quinquefolii 6-8 times amount concentration of volume percent is ethanol extraction 2-3 time of 40%-80%, each 1.5-2 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.10-1.20, obtains concentrated solution A；Folium Mori soak 2-3 time with the 6-10 times amount water temperature of 60-80 DEG C, each 1-2 hour, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.10-1.20, obtains concentrated solution B；Concentrated solution A, B are separately dried, and obtain dried object I, II；Dried object I, II are mixed homogeneously with L-arabinose, obtain dried object III；Dried object III, is active component.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108713738A (en) * | 2018-04-17 | 2018-10-30 | 北京中和鸿业医药科技有限公司 | A kind of American Ginseng siberian solomonseal rhizome composition, preparation method, preparation and application |
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| CN104147132A (en) * | 2014-08-20 | 2014-11-19 | 哈尔滨顺亿堂医药生物科技开发有限公司 | Soft gel capable of reducing blood sugar and adjusting insulin secretion and production method |
| CN104173451A (en) * | 2014-09-12 | 2014-12-03 | 赵全成 | Application of natural pharmaceutical composition in blood glucose-reducing drugs and health food |
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| CN1366552A (en) * | 2000-02-01 | 2002-08-28 | 尤尼蒂卡株式会社 | Process for producing L-arabinose, L-arabinose-containing enzymatically processed products, diet foods, diabetic diet foods and fruit or vegetable juices and process for producing same |
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Application publication date: 20160727 |
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