CN104147132A - Soft gel capable of reducing blood sugar and adjusting insulin secretion and production method - Google Patents
Soft gel capable of reducing blood sugar and adjusting insulin secretion and production method Download PDFInfo
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Abstract
The invention relates to a soft gel capable of reducing blood sugar and adjusting insulin secretion and a production method. In the prior art, many method uses American ginseng to adjust blood sugar, if the drug does not suit the remedy to the case, the improper drug amount can cause the reverse effect. The soft gel capable of reducing blood sugar and adjusting insulin secretion comprises a capsule case, a content object is filled in the capsule case, the content object comprises the following raw materials by weight: 70-80 parts of American ginseng extract product, 70-80 parts of balsam pear extract product, 70-80 parts of mulberry leaf extract product, 50-60 parts of propolis powder, 9-13 parts of chromium-rich yeast, 440-455 parts of soybean oil and 30-40 parts of beewax; the capsule case comprises the following raw materials by weight: 280-320 parts of gelatin, 120-130 parts of glycerin, 270-330 parts of purifying water and 7-11 parts of monascus red. The soft gel is used for reducing blood sugar.
Description
technical field:
the present invention relates to a kind of soft capsule and manufacture method that can reduce blood glucose regulation insulin secretion.
background technology:
treatment diabetes at present, blood sugar lowering oral drugs are of a great variety, use Radix Panacis Quinquefolii to regulate the also a lot of of blood glucose, if still medicine is not suited the medicine to the illness, consumption is improper, also can play retroaction.If overdose can bring mood excitement, irritated worried, insomnia to people, there is similar corticosteroid central nervous excitation and the irritations such as personality forfeiture or mental disorder, to have a headache in addition dizzy etc., but Radix Ginseng is goodies does not eat indiscriminately and eat more.
although Radix Panacis Quinquefolii has good tonic effect, not everybody is suitable takes, and also not one eats, and immunity will improve immediately.From taking generation effect in health, need a process, Radix Panacis Quinquefolii belongs to the medicine of a cold nature, should boosting qi and nourishing yin.If health has heat symptom-complex, such as xerostomia agitation, feverish sensation over the palm, face are rubescent, the frequent fatigue and weak of health, use Radix Panacis Quinquefolii class tonic can reach the object of taking good care of.Otherwise, if bring up phlegm when one coughs, saliva is many or while having the states such as edema, just should avoid taking Radix Panacis Quinquefolii, otherwise will increase the weight of the state of an illness, spring and summer climate was do, be relatively applicable to taking Radix Panacis Quinquefolii, autumn, winter the Radix Ginseng of taking preferably.In Radix Panacis Quinquefolii, contain a kind of ginsenoside's of crying composition, there is the effect of strengthening body resistance.
diabetes are one group of metabolic diseases taking hyperglycemia as feature, hyperglycemia be due to defect of insulin secretion or its biological agent impaired, or both have concurrently and cause, due to the long-standing hyperglycemia of diabetes patient, cause various tissues, particularly chronic lesion, the dysfunction of eye, kidney, heart, blood vessel, nerve.Although some medical instrument has certain curative effect, can prevent, reduce, control blood glucose, regulate insulin secretion, prevent diabetes complication, the Therapeutic Method of achieving many things at one stroke is little.
conventionally when people take, be all to take by capsule, although because the content of beary metal of capsule shells has strict regulation, how much still have content overproof, the taking of long period has an Accumulation of heavy metals problem and easily causes health to endanger.
summary of the invention:
the object of this invention is to provide a kind of soft capsule and manufacture method that can reduce blood glucose regulation insulin secretion.
above-mentioned object realizes by following technical scheme:
a kind of soft capsule that can reduce blood glucose regulation insulin secretion, its composition comprises: capsule shells, in described capsule shells, have content, described content comprises that parts by weight are the Radix Panacis Quinquefolii extract of 70-80, the Fructus Momordicae charantiae extract that parts by weight are 70-80, the Folium Mori extract that parts by weight are 90-110, the peak rubber powder that parts by weight are 50-60, the Rich chromium yeast that parts by weight are 9-13, the soybean oil that parts by weight are 440-455, the peak wax that parts by weight are 30-40; Described capsule shells comprises that parts by weight are the gelatin of 280-320, the glycerol that parts by weight are 120-130, the purified water that parts by weight are 270-330, the red yeast rice that parts by weight are 7-11.
the described soft capsule that can reduce blood glucose regulation insulin secretion, described content comprises that parts by weight are 70 Radix Panacis Quinquefolii extract, the Fructus Momordicae charantiae extract that parts by weight are 70, the Folium Mori extract that parts by weight are 90, the peak rubber powder that parts by weight are 50, the Rich chromium yeast that parts by weight are 9, the soybean oil that parts by weight are 440, the peak wax that parts by weight are 30; Described capsule shells comprises that parts by weight are 280 gelatin, the glycerol that parts by weight are 120, the purified water that parts by weight are 270, the red yeast rice that parts by weight are 7.
the described soft capsule that can reduce blood glucose regulation insulin secretion, described content comprises that parts by weight are 80 Radix Panacis Quinquefolii extract, the Fructus Momordicae charantiae extract that parts by weight are 80, the Folium Mori extract that parts by weight are 110, the peak rubber powder that parts by weight are 60, the Rich chromium yeast that parts by weight are 13, the soybean oil that parts by weight are 455, the peak wax that parts by weight are 40; Described capsule shells comprises that parts by weight are 320 gelatin, the glycerol that parts by weight are 130, the purified water that parts by weight are 330, the red yeast rice that parts by weight are 11.
the described soft capsule that can reduce blood glucose regulation insulin secretion, described content comprises that parts by weight are 75 Radix Panacis Quinquefolii extract, the Fructus Momordicae charantiae extract that parts by weight are 75, the Folium Mori extract that parts by weight are 100, the peak rubber powder that parts by weight are 55, the Rich chromium yeast that parts by weight are 11, the soybean oil that parts by weight are 448, the peak wax that parts by weight are 36; Described capsule shells comprises that parts by weight are 300 gelatin, the glycerol that parts by weight are 126, the purified water that parts by weight are 300, the red yeast rice that parts by weight are 9.
a manufacture method for the described soft capsule that can reduce blood glucose regulation insulin secretion, the method comprises the steps:
(1) processing of raw material: sieve, weigh: by Radix Panacis Quinquefolii extract, Fructus Momordicae charantiae extract, Folium Mori extract, cross 80 mesh sieves respectively, by above-mentioned parts by weight, accurately weighing, for subsequent use;
(2) batching: by Radix Panacis Quinquefolii extract, Fructus Momordicae charantiae extract, Folium Mori extract, mix homogeneously 20min,
obtain mixture; When soybean oil is heated to 75 DEG C, add Cera Flava, stir melting 1h, obtain oily wax liquid, be cooled to 50 DEG C of insulations, stand-by; Peak rubber powder, Rich chromium yeast, mixture are added in oily wax liquid successively, and limit edged stirs, and 30min crosses colloidal grinding after mix homogeneously, emulsifying fineness 30 ~ 40 μ m, and the de-bubble to the greatest extent of-0.06 ~-0.08Mpa, obtains content stand-by;
(3) change glue: first will in purified water, putting into of glycerol glue tank, be heated to 70 DEG C, under stirring, gelatin, red yeast rice are slowly added, and continue to be heated to 70 DEG C, stirring boils 1h, de-bubbled-0.06 ~-0.08 Mpa, 65 ~ 70 DEG C, obtain glue, and 100 orders filter, at 60 DEG C, place 4 ~ 6h, for subsequent use;
(4) pelleting: start soft capsule press, compacting soft gelatin capsule, 18 ~ 22 DEG C of production environment temperature, rubber thickness 0.75 ~ 0.85, relative humidity 30 ~ 40%, controls loading amount 0.8g/ grain;
(5) sizing: the soft gelatin capsule suppressing is shaped in rotating cage with tape transport, 18 ~ 22 DEG C of temperature, relative humidity 30 ~ 40%, time 4h;
(6) wash ball, dry: clean soft gelatin capsule with 95% edible ethanol, until soft gelatin capsule any surface finish, bright, without grease, is then sent into soft gelatin capsule hothouse dry, control 24 ~ 26 DEG C of hothouse temperature, relative humidity 20 ~ 30%, dry 24h;
(7) lamp is picked up: dried soft capsule is placed on lamp inspection machine, and special messenger picks, and conscientiously checks soft capsule presentation quality, by empty pocket, special-shaped ball, flat ball, thin-walled ball, not of uniform sizely cause that ball, surface are untidy, bonding, distortion, leak capsule defective work and sort out;
(8) packaging: soft capsule is packed, and 120/bottle, oral solid drug adopts high-density polyethylene bottle.
beneficial effect:
1. auxiliary treatment, diabetes and hyperlipidemia complications disease, diabetic neuropathy and the complication of the suitable impaired glucose tolerance crowd of the present invention, senile diabetes crowd, type 2 diabetes mellitus and High-risk Group of Diabetes, type 1 diabetes, cardiovascular and cerebrovascular disease crowd's auxiliary treatment, have more the health-caring function of normal population, diabetes spp is in traditional Chinese medical science diabetes, taking the deficiency of YIN as this, scorching is mark.With the passing of time pathological changes internal organs, mainly at lung, spleen, kidney, quench one's thirst, consumption impairment of QI Tianjin.Therefore with Radix Panacis Quinquefolii boosting qi and nourishing yin, clearing away heat and promoting production of body fluid is monarch, the scorching lung of the most easily attacking, with the property clearing away lung-heat of Folium Mori bitter cold, lung moistening is dry is minister; Dry bones clearing away summer-heat heat extraction, can separate calentura excessive thirst drink and draw; Propolis tonify deficiency consumption, only quenches one's thirst, and is all adjuvant with Fructus Momordicae charantiae, and four are share, and boosting qi and nourishing yin improves the symptom of quenching one's thirst.Chromium, it acts on the Insulin receptor INSR on cell membrane, is " Booster " that promotes insulin action, and scarce chromium makes tissue reduce insulin sensitivity, thereby causes the generation of diabetes.Therefore, chromium supplement is the Main Means that improves diabetes patient's insulin sensitivity, and above all raw materials share, and jointly reach the health care of auxiliary hyperglycemic.
radix Panacis Quinquefolii extract in the present invention, Fructus Momordicae charantiae extract, Folium Mori extract synthesize can promote the synthetic of glucose tolerance factor (GTF), improves the bioavailability of insulin human.Reduce the dependence of type i diabetes patient to insulin, reduce the side effect of insulin preparation.The generation of prevention type ii diabetes, promotes type ii diabetes patient's rehabilitation.The reason induced Diabetics such as prevention of obesity and high fat, high sugar and high protein diet.The adverse consequences that beta Cell of islet excreting insulin is suppressed without feedback, can life-time service.
of the present invention by gelatin, glycerol, pure water, the synthetic capsule shells of red yeast rice, belong to natural green
capsule, wherein gelatin is a kind of using by the animal bone boiling, the peptide molecule polymeric material that skin and muscle tendon are made, is the hydrolyzate of collagenic protein, contains a large amount of aminoacid, has higher nutritive value.
red yeast rice is exactly that Monas cuspurpureus Went grinds later powder, so because have higher color valency to be widely used in food production.Monascus is inoculated on the rice steaming, cultivation a period of time just can obtain Monas cuspurpureus Went.Monas cuspurpureus Went is the natural fermented product of microorganism, and human body is safe from harm.
radix Panacis Quinquefolii in the present invention can improve immunity Radix Panacis Quinquefolii as the first-selected medical material of qi-tonifying health-care, can promote that serum albumin is synthetic, bone marrow protein is synthetic, organ albumen is synthetic etc., improves immunity of organisms, and anticancer growth, effectively resists cancer.
promote blood vigor length to take Radix Panacis Quinquefolii and can reduce blood coagulation, suppress platelet aggregation, atherosclerosis and promote Growth of red blood cells, increase hematochrome.
treatment diabetes Radix Panacis Quinquefolii can reduce blood glucose, regulates insulin secretion, promote carbohydrate metabolism and lipid metabolism, treatment diabetes are had to certain assosting effect.
the Saponin strengthening in central nervous system function Radix Panacis Quinquefolii can effectively strengthen nervus centralis, reach with all worries set aside with fixed attention, the effect such as allaying tiredness, memory reinforcing, applicable to symptoms such as insomnia, irritated, hypomnesis and senile dementias.
protection cardiovascular system informal dress Radix Panacis Quinquefolii can arrhythmia, resist myocardial ischemia, anti-cardiac muscle oxidation, strengthening cardiac contractility ability, and patients with coronary heart disease Symptoms is that deficiency of both QI and YIN, palpitation and short breath can long-term taking Radix Panacis Quinquefoliis, evident in efficacy.Effect of Radix Panacis Quinquefolii is also to regulate blood pressure, can effectively reduce temporary and persistency blood pressure, contributes to the recovery of the diseases such as hypertension, arrhythmia, coronary heart disease, acute myocardial infarction, cerebral thrombosis.
fructus Momordicae charantiae extract in the present invention can reduce blood glucose; the fresh juice of Fructus Momordicae charantiae; the material that contains Charantin and similar insulin; there is good hypoglycemic activity; it is the ultimate food of diabetics; can also promote diet, anti-inflammatory antipyretic: the Charantin in Fructus Momordicae charantiae and bitter principle energy appetite stimulator, spleen benefiting and stimulating the appetite simultaneously; Contained alkaloids substance quinine, has that diuresis is invigorated blood circulation, effect of anti-inflammatory antipyretic, the improving eyesight that clears away heart-fire; Cancer-resisting: bitter melon protein matter composition and vitamin C can improve the immunologic function of body, has immunocyte to kill the effect of cancerous cell; Succus Momordicae charantiae contains certain protein ingredient, can strengthen the huge ability of biting, effective to lymphosarcoma and leukemia clinically; The trypsin inhibitor extracting from bitter melon seed, can the secreted protease out of anticancer, stops malignant growth.
folium Mori in Folium Mori extract of the present invention are kings of plant, there is the good reputation of " Radix Ginseng is vulcanized; Folium Mori are mended clearly ". Folium Mori, it is " integration of edible and medicinal herbs " plant that health ministry is confirmed, listed in by international food health organization one of " mankind's 21 centurys ten large health food ", become the green new food of mankind source, selecting the tender Folium Mori of superior, the free of contamination high-quality of ecological environment is raw material, cures refining forming through science.Selecting Folium Mori not add any additive in whole cultivation process, is all-natural product, and side is not containing any oxious component.The technique of employing science and method have been removed organic acid bitterness, astringent taste in Folium Mori, taste glycol, the delicate fragrance people of overflowing.Especially have hypoglycemic activity, wherein contained ecdysterone all has blood sugar reducing function to the blood sugar increasing of several different methods induction, can promote that conversion of glucose is glycogen.
propolis in propolis powder of the present invention is pure natural substance, containing any hormone, the aspects such as propolis powder can improve immunity, reduces blood glucose, prophylaxis of tumours, antioxidation, protects the liver, blood fat reducing, anti-inflammation, antiviral, various dermatosis and digestion, diseases of urinary system, bronchitis, antitumor, oral ulcer have all obtained good effect.
rich chromium yeast of the present invention is natural Regulation of blood glucose agent, and micro elements needed by human-chromium of bringing into play special role in body carbohydrate metabolism and lipid metabolism activates insulin active, regulates blood glucose, suppresses sugar and is converted into fat.Strengthen insulin active, control blood glucose.Can regulate fat stores amount, help loss of weight.Reduce the content of blood cholesterol and triglyceride, prevention cardiovascular diseases.
brief description of the drawings:
accompanying drawing 1 is production technological process of the present invention.
detailed description of the invention:
embodiment 1:
a kind of soft capsule that can reduce blood glucose regulation insulin secretion, its composition comprises: capsule shells, in described capsule shells, have content, described content comprises that parts by weight are the Radix Panacis Quinquefolii extract of 70-80, the Fructus Momordicae charantiae extract that parts by weight are 70-80, the Folium Mori extract that parts by weight are 90-110, the peak rubber powder that parts by weight are 50-60, the Rich chromium yeast that parts by weight are 9-13, the soybean oil that parts by weight are 440-455, the peak wax that parts by weight are 30-40; Described capsule shells comprises that parts by weight are the gelatin of 280-320, the glycerol that parts by weight are 120-130, the purified water that parts by weight are 270-330, the red yeast rice that parts by weight are 7-11.
three times on the one, a 2-5 capsule.
embodiment 2:
according to the soft capsule that can reduce blood glucose regulation insulin secretion described in embodiment 1, described content comprises that parts by weight are 70 Radix Panacis Quinquefolii extract, the Fructus Momordicae charantiae extract that parts by weight are 70, the Folium Mori extract that parts by weight are 90, the peak rubber powder that parts by weight are 50, the Rich chromium yeast that parts by weight are 9, the soybean oil that parts by weight are 440, the peak wax that parts by weight are 30; Described capsule shells comprises that parts by weight are 280 gelatin, the glycerol that parts by weight are 120, the purified water that parts by weight are 270, the red yeast rice that parts by weight are 7.
embodiment 3:
according to the soft capsule that can reduce blood glucose regulation insulin secretion described in embodiment 1, described content comprises that parts by weight are 80 Radix Panacis Quinquefolii extract, the Fructus Momordicae charantiae extract that parts by weight are 80, the Folium Mori extract that parts by weight are 110, the peak rubber powder that parts by weight are 60, the Rich chromium yeast that parts by weight are 13, the soybean oil that parts by weight are 455, the peak wax that parts by weight are 40; Described capsule shells comprises that parts by weight are 320 gelatin, the glycerol that parts by weight are 130, the purified water that parts by weight are 330, the red yeast rice that parts by weight are 11.
embodiment 4:
according to the soft capsule that can reduce blood glucose regulation insulin secretion described in embodiment 1, described content comprises that parts by weight are 75 Radix Panacis Quinquefolii extract, the Fructus Momordicae charantiae extract that parts by weight are 75, the Folium Mori extract that parts by weight are 100, the peak rubber powder that parts by weight are 55, the Rich chromium yeast that parts by weight are 11, the soybean oil that parts by weight are 448, the peak wax that parts by weight are 36; Described capsule shells comprises that parts by weight are 300 gelatin, the glycerol that parts by weight are 126, the purified water that parts by weight are 300, the red yeast rice that parts by weight are 9.
embodiment 5:
the manufacture method that can reduce the soft capsule of blood glucose regulation insulin secretion, the method comprises the steps:
(1) processing of raw material: sieve, weigh: by Radix Panacis Quinquefolii extract, Fructus Momordicae charantiae extract, Folium Mori extract, cross 80 mesh sieves respectively, by above-mentioned parts by weight, accurately weighing, for subsequent use;
(2) batching: by Radix Panacis Quinquefolii extract, Fructus Momordicae charantiae extract, Folium Mori extract, mix homogeneously 20min,
obtain mixture; When soybean oil is heated to 75 DEG C, add Cera Flava, stir melting 1h, obtain oily wax liquid, be cooled to 50 DEG C of insulations, stand-by; Peak rubber powder, Rich chromium yeast, mixture are added in oily wax liquid successively, and limit edged stirs, and 30min crosses colloidal grinding after mix homogeneously, emulsifying fineness 30 ~ 40 μ m, and the de-bubble to the greatest extent of-0.06 ~-0.08Mpa, obtains content stand-by;
(3) change glue: first will in purified water, putting into of glycerol glue tank, be heated to 70 DEG C, under stirring, gelatin, red yeast rice are slowly added, and continue to be heated to 70 DEG C, stirring boils 1h, de-bubbled-0.06 ~-0.08 Mpa, 65 ~ 70 DEG C, obtain glue, and 100 orders filter, at 60 DEG C, place 4 ~ 6h, for subsequent use;
(4) pelleting: start soft capsule press, compacting soft gelatin capsule, 18 ~ 22 DEG C of production environment temperature, rubber thickness 0.75 ~ 0.85, relative humidity 30 ~ 40%, controls loading amount 0.8g/ grain;
(5) sizing: the soft gelatin capsule suppressing is shaped in rotating cage with tape transport, 18 ~ 22 DEG C of temperature, relative humidity 30 ~ 40%, time 4h;
(6) wash ball, dry: clean soft gelatin capsule with 95% edible ethanol, until soft gelatin capsule any surface finish, bright, without grease, is then sent into soft gelatin capsule hothouse dry, control 24 ~ 26 DEG C of hothouse temperature, relative humidity 20 ~ 30%, dry 24h;
(7) lamp is picked up: dried soft capsule is placed on lamp inspection machine, special messenger picks, conscientiously check soft capsule presentation quality, by empty pocket, special-shaped ball, flat ball, thin-walled ball, not of uniform sizely cause that ball, surface are untidy, bonding, distortion, leak the defective works such as capsule and sort out;
(8) packaging: soft capsule is packed, and 120/bottle, oral solid drug adopts high-density polyethylene bottle.As shown in Figure 1.
embodiment 6:
the above-mentioned soft capsule that can reduce blood glucose regulation insulin secretion, described Radix Panacis Quinquefolii extract, be again Radix Panacis Quinquefolii, Radix Panacis Quinquefolii, U.S.'s Radix Ginseng etc., original producton location, at America & Canada, is the root for Araliaceae Radix Panacis Quinquefolii, and China's Radix Ginseng is a female compatriot, blood relationship is very near, but drug effect is different, maximum advantage is that temperature compensation effect is good, there will not be the symptom of getting angry of epistaxis one class.There is obvious YIN nourishing and QI supplementing with other component synergism, the mind calming and mentality promoting and clearing away heat and promoting production of body fluid, the double effects that pathogenic fire reducing is relieved summer heat, Radix Panacis Quinquefolii is cool in nature and mend, all wishs are not subject to Radix Ginseng warm person with Radix Ginseng all can with it, except daily health care, through clinical verification, Radix Panacis Quinquefolii also has certain curative effect to hypertension and cardiac muscular dystrophy, coronary heart diseases and angina pectoris etc.Particularly suitable for the disease such as uncomfortable in chest, nervous vexed of being caused by heart disease.Modern pharmacology studies have shown that: Radix Panacis Quinquefolii sweet in the mouth cool in nature, and outside the effect apart from boosting qi and nourishing yin, can also relieve inflammation or internal heat and promote the production of body fluid, to deficiency of body fluid, thirsty dryness of the tongue has suitable curative effect.Long-term taking, can refreshment, promoting the production of body fluid to quench thirst, adjustment, can improve the immunologic function of body, the excellent choosing of nourishing really and keeping fit.
mainly treatment diabetes:
(1) the present invention can reduce blood glucose, regulates insulin secretion, promote carbohydrate metabolism and lipid metabolism, and treatment diabetes are had to certain assosting effect.
(2) strengthen central nervous system function: the present invention can effectively strengthen nervus centralis, reach with all worries set aside with fixed attention, the effect such as allaying tiredness, memory reinforcing, applicable to symptoms such as insomnia, irritated, hypomnesis and senile dementias.
(3) protection cardiovascular system: can arrhythmia, resist myocardial ischemia, anti-cardiac muscle oxidation, strengthening cardiac contractility ability, patients with coronary heart disease Symptoms is that deficiency of both QI and YIN, palpitation and short breath can long-term taking Radix Panacis Quinquefoliis, evident in efficacy.Effect of Radix Panacis Quinquefolii is also to regulate blood pressure, can effectively reduce temporary and persistency blood pressure, contribute to the recovery of the diseases such as hypertension, arrhythmia, coronary heart disease, acute myocardial infarction, cerebral thrombosis, can strengthen the mobility of cardiac muscle and enhancing heart, can prevent and treat cardiovascular and cerebrovascular disease and have and resist myocardial ischemia and Antishock function, and can obviously reduce blood fat.
(4) improve immunity, as the first-selected medical material of qi-tonifying health-care, can promote that serum albumin is synthetic, bone marrow protein synthetic, organ albumen is synthetic etc., improve immunity of organisms, anticancer growth, effectively opposing cancer, Radix Panacis Quinquefolii is also that tonifying recipes has supplementary needed by human body simultaneously, improves the effect of body's immunity.
(5) promote blood vigor: can reduce blood coagulation, suppress platelet aggregation, atherosclerosis and promote Growth of red blood cells, blood pressure is had to Accommodation, make temporary or persistency blood pressure drops. suppress arteriosclerosis and promote Growth of red blood cells, increasing hematochrome
(6) liver is had to the secretion that regulates accessory suprarenal glands element, the effect enhancing metabolism, can physical strength reinforcing and athlete's tool is greatly benefited, anticancer growth, encouraged digestion, to chronic gastropathy and the weak effect that helps of the intestines and stomach, there is the effects such as anti-hypoxia, high temperature resistance, cold-resistant, diuresis, calmness, hemostasis.
embodiment 7:
the above-mentioned soft capsule that can reduce blood glucose regulation insulin secretion, the fresh juice of Fructus Momordicae charantiae in described Fructus Momordicae charantiae extract, the material that contains Charantin and similar insulin, there is good hypoglycemic activity, it is the ultimate food of diabetics, can also promote diet simultaneously, anti-inflammatory antipyretic, Charantin in Fructus Momordicae charantiae and bitter principle energy appetite stimulator, spleen benefiting and stimulating the appetite, contained alkaloids substance quinine, there is diuresis to invigorate blood circulation, anti-inflammatory antipyretic, effect of improving eyesight clears away heart-fire, cancer-resisting, bitter melon protein matter composition and vitamin C can improve the immunologic function of body, immunocyte there is kill the effect of cancerous cell, Succus Momordicae charantiae contains certain protein ingredient, can strengthen the huge ability of biting, effective to lymphosarcoma and leukemia clinically, and the trypsin inhibitor extracting from bitter melon seed can the secreted protease out of anticancer, stops malignant growth.
the present invention contains Fructus Momordicae charantiae extract, in a Fructus Momordicae charantiae, contain 0.4% expensive as the fat-reducing magistery of gold---main Charantin, albuminoid active substance (being α-Charantin, β-Charantin, MAP30) insulin-like activity substance (being polypeptide-P) and the several amino acids of containing of high energy fat eliminating element.Give the Ms that likes to be beautiful, can accelerate toxin expelling, invite many women " to seek joy amidst sorrow ", always enjoy it.To the heart, lung, stomach have cool, thirst-quenching, have except pathogenic heat, control red fire-toxin gas, rush down the six channels excess-fire, tired, the improving eyesight that clears away heart-fire is quenched the thirst, separated to QI invigorating, can appetite strengthening, effect of the liver nourishing of nourishing blood, the kidney invigorating of profit spleen.The effect such as enhance metabolism.The diuresis of/kidney tonifying, heat-clearing and toxic substances removing, blood fat reducing, antiviral.Find according to the study, it has the sugar effect of significantly occulting blood, and diabetes are had to certain curative effect.It also has certain anti-virus ability and effect of anti-cancer.
increased the product of the present invention of Fructus Momordicae charantiae extract, had the effect of the blood glucose of reduction with the collaborative left and right of other compositions, rabbit normal and trouble alloxan diabetes gavages after Fructus Momordicae charantiae juice, can make blood glucose obviously reduce.The rat that subcutaneous injection anterior pituitary extractum causes hyperglycemia, the water extract that gavages Fructus Momordicae charantiae juice also has the hypoglycemic effect of falling.Can reduce blood glucose to the oral Charantin of rabbit, model of action is similar and stronger to tolbutamide, reduces not disappearance completely of blood glucose effect, therefore its blood sugar lowering comprises two of pancreas and non-pancreas kinds of effects to extracing the cat of pancreas.Also have and think that the hypoglycemic activity of the dry extract of Fructus Momordicae charantiae juice and the fruit rabbit to normal and diabetes is uncertain.The alcoholic extract of the oral Fructus Momordicae charantiae of diabetes patient does not reduce blood glucose.
the present invention has the sugar effect of significantly occulting blood, and diabetes are had to certain curative effect.It also has certain anti-virus ability and effect of anti-cancer.What can testify is that Fructus Momordicae charantiae goods have corresponding effective ingredient, for example balsam pear tea be the dioecism momordica root growing between the pollution-free blue montains and green waters in mountainous areas of the western Fujian be raw material, dry refining forming through sterilization, the healthy composition of interior water content multiple beneficial, first micro-hardship is then micro-sweet for entrance, unique flavor, often drinks and not only can supplement multivitamin, mineral, and can prevent and treat dysentery, separates heatstroke heating, antitumor, prevents and treats diabetes.Current known Fructus Momordicae charantiae not only has heat-clearing and toxic substances removing, improving eyesight, antipyretic effect, but also there is the effects such as blood sugar lowering, antitumor, antiviral, antibacterial, Promote immunity power, also can be used for preventing and treating the effects such as heatstroke, dysentery, malignant boil, acute conjunctivitis pain, it also has a good reputation---vegetable in medicine.
embodiment 8:
the above-mentioned soft capsule that can reduce blood glucose regulation insulin secretion, in the present invention, adopt Folium Mori extract as synergistic composition, Folium Mori are wherein kings of plant, there is the good reputation of " Radix Ginseng is vulcanized; Folium Mori are mended clearly ". Folium Mori, it is " integration of edible and medicinal herbs " plant that health ministry is confirmed, listed in by international food health organization one of " mankind's 21 centurys ten large health food ", become the green new food of mankind source, selecting the tender Folium Mori of superior, the free of contamination high-quality of ecological environment is raw material, cures refining forming through science.Selecting Folium Mori not add any additive in whole cultivation process, is all-natural product, and side is not containing any oxious component.The technique of employing science and method have been removed organic acid bitterness, astringent taste in Folium Mori, taste glycol, the delicate fragrance people of overflowing.Especially have hypoglycemic activity, wherein contained ecdysterone all has blood sugar reducing function to the blood sugar increasing of several different methods induction, can promote that conversion of glucose is glycogen.
increase this product of Folium Mori extract, can:
(
1) reduce blood glucose: utilize Folium Mori to contain a kind of deoxidation mycin.Can stop carbohydrate-splitting enzyme to play a role.The Folium Mori original has the function that suppresses blood glucose rising, and its major function composition is " alkaloid " in Folium Mori, and this is a kind of composition with specific function, and it is that other animal and plant are unexistent.Japan medical science circle claims this specific group to become " DNJ " material.Its Main Function is to suppress saccharase, maltase, the sweet sugar of a-glucose, the diastatic decomposition of a-, can stimulate insulin secretion, and reduces insulin decomposition rate.(2) blood pressure lowering principle: the main composition of blood pressure lowering is γ-aminobutyric acid.γ-aminobutyric acid in Folium Mori has the function of blood pressure lowering.According to zoopery, in the feedstuff of naturally-occurring hypertension white mice, add powder of Folium Mori, through feeding a couple of days continuously, find that hypertension symptom recurrent number significantly reduces, this plays a role relevant with the γ-aminobutyric acid in Folium Mori.(3) fat-reducing fat eliminating: Folium Mori tea can be lost weight, relevant with the effect of Folium Mori " detumescence ", " purifying the blood " exactly.Why Folium Mori tea can subside a swelling, and is because Folium Mori have the effect of diuretic.Diuretic effect is different from diuresis, not only can promote to urinate, and can also make the excessive moisture amassing in cell drain.So Folium Mori tea can be improved so-called edema phenomenon.Purify the blood is that neutral fat and cholesterol by superfluous in blood clears.Neutral fat in blood or cholesterol increase are exactly too much hyperlipidemia.So fat people mostly is hyperlipidemia patient.Folium Mori are improved the effect of this hyperlipidemia.(4) the skin ulcer speckle dispelling that disappears is more improved looks: studies have shown that in recent years, and Folium Mori also have good beautifying skin effect, and particularly the acne to face, brown macules have reasonable curative effect.Folium Mori are rich in the trace element of chromocor compound, phenols, aminoacid, organic acid, carotene, vitamin and multiple needed by human, this metabolism to improvement and regulation of skin tissue, though suppress especially Pigmented generation and develop all have positive role.In addition, adhere to that normal drink reduces the stagnant of lipofuscin in skin or internal organs (being senile plaque) in addition.(5) in addition, hyperlipemia patient's blood viscosity is high, and flowing in blood capillary is not smooth especially.Blood capillary only has the 1/100 so thick of our hair, so easily stop up.Myocardial infarction and cerebral hemorrhage are all the results that blood capillary stops up.In Folium Mori, contain strengthening blood capillary, reduce the flavones ingredient of blood viscosity, so in fat-reducing, improving hyperlipemia, have again the effect of prevention myocardial infarction and cerebral hemorrhage.
near Black Sea, there is a Changshou village, villager's average life here 120 years old, the highest reaches 160 years old unexpectedly.Through investigating: spread all over mulberry here, villager ancestors' edible mulberry and drink Folium Mori tea.It is not unique, but has its counterpart, near Ya Shabazan mountain area Moscow, and here also all over planting mulberry, also ancestors' edible mulberry and drink Folium Mori tea of the villager here, many old men also live by 140 years old.It is investigated, only Forest Park, ancient riverbed of the Yellow River Xiajin Xi Yan mono-village reaches 9 ten days person 8 people the longevity, reaches 8 ten days persons very many, therefore ancient mulberry claims again " chin or cheek longevity tree ".
embodiment 9:
the above-mentioned soft capsule that can reduce blood glucose regulation insulin secretion, described propolis is the Apis resin gathering from plant plumule and trunk, the one that on Apis, the secretions in Hubei Province, Cera Flava, a small amount of pollen process has aromatic odor, tough natural mixture, when burning, have special fragrance, mildly bitter flavor is puckery.The main component of propolis has flavone, the rare class of terpene, organic acid, armaticity aldehydes and several amino acids enzyme, vitamin, mineral etc., and in propolis, the effective ingredient of complexity, is the material base of good natural health-care products and medicine.Propolis is described as " the most perfect natural broad ectrum antibiotic ", " natural immunity reinforcing agent ", " street cleaner of blood vessel ", " healthy patron saint " real story: winter; toy is often rushed in Nidus Vespae and is stolen honey and eat and stung extremely by Apis; (mouselet is common) corpse cannot be taken out of outside nest; Apis can be coated layer of substance in the above; and several years imputrescibilities, this material is exactly propolis.Magical effect of propolis:
(1) propolis can reduce blood glucose: propolis energy activating cell, promote tissue regeneration, and repair islet cells and the tissue of disease damage, help to reduce blood glucose; Diminish inflammation, treatment is infected, prevention and treatment infection complication; Reduce blood fat, vessel softening, improve microcirculation, diabetics is taken propolis can prevent visual deterioration and cardiovascular and cerebrovascular complication; Regain one's strength, eliminate " three-many-one-little " symptom; Diabetes patient adheres to taking propolis can reinforced immunological function, and health invigorating, improves the quality of living.
(2) effect of Propolis on Diabetes Mellitus: why effective to diabetics propolis is, the evidence providing according to pharmacology prompting: (1) propolis has para-insulin effect.Be that it has the effect that promotes to utilize the synthetic hepatic glycogen of exogenous glucose.(2) capryl alcohol containing in propolis and butterfly compounds.Also there is a good hypoglycemic effect even if studies have shown that these material content are very low.(3) propolis has good bactericidal antiphlogistic effect.Prevent that pathogenic bacteria from, to the infecting of islet cells, shielding to it, and can activate islet cells, to the effect that the islet cells of pathological changes occurs and organize treatment and recover.(4) propolis is the Natural antioxidant the activity that can obviously improve antioxidant (SOD), reduces injury and prevention and the multiple diabetic complication for the treatment of of radical pair cell.
some flavone compounds in propolis and terpenoid can promote to utilize the effect of the synthetic hepatic glycogen of exogenous glucose, in them, also have some compounds as catalpol, pterostibene etc. have obvious hypoglycemic activity.According to the research of Chinese scholar and clinical observation, propolis extract blood sugar lowering total effective rate is up to 94.7%.But the hypoglycemic effect of propolis is not quite alike to each diabetics.In general, have patient's (type Ⅱdiabetes mellitus) of 39%, taking propolis about one week, blood glucose target just can return to normal level.Have 55% patient (1 and type Ⅱdiabetes mellitus) on the basis of original treatment, to take propolis, this part patient, is adding after propolis, can make the blood glucose always remaining high progressively reduce.For type 1 diabetes patient, can gradually reduce insulin dosage after taking propolis.Approximately have 5.3% patient no matter how to take propolis, blood glucose does not change substantially.But, can prevent and treat various complication from propolis, no matter the hypoglycemic effect of propolis how, propolis concerning each diabetics all tool be of great significance.Clinical observation and widely practical application show, propolis extract has at least for the therapeutic efficiency of diabetics: help to reduce blood glucose; Anti-inflammation, eliminating toxin, prevention and the various infection for the treatment of; Reduce blood fat, vessel softening, improve microcirculation, prevent vascular lesion; Regulate immunity, improve resistance against diseases; Regain one's strength, eliminate " three-many-one-little " symptom; Health invigorating, improves the quality of living.
(3) propolis is to improving the effect of immunity: propolis is a kind of natural efficient immunostimulant, can stimulate the immune function of body,, the vigor of enhancing macrophage.By the evidence in the body with propolis or cooperation antigen injection Big and Little Rats, rabbit, pig and calf, propolis can promote the immunologic process of body, and the phagocytic activity of the interior leukocyte of body and macrophage is strengthened greatly; Spleen, thymus are produced to various wholesome effects; Propolis can make content and active the increasing of total protein in blood and gamma globulin, improves specificity and the non-specific immunity of body.Therefore, propolis is improved the effect of immunity of organisms.Non-specific and the specific immune function of propolis energy enhancing body.By zoopery, observe propolis extract to having transplanted the impact of S180 sarcoma immune function of mice, show that propolis extract can make thymus/body weight ratio increase P < 0.05, leukocyte maintains normal level, and splenocyte killing tumor cell ability strengthens P < 0.05.The research of Luan Jinshui etc. (2000) shows, propolis can strengthen immunosuppressant model mice Peritoneal Macrophage Phagocytosis (P < 0.05 increases thymus index P < 0.05), but that spleen index changes is not obvious.Carry out zoopery with propolis, show that propolis can strengthen mice delayed allergy, improve the ability that Hemolysin is tired and Turnover of Mouse Peritoneal Macrophages is engulfed chicken red blood cell.Adopt immunologic hypofunction mouse model (HC mouse model), observe the impact of propolis ethanol extract on HC immune function of mice, result shows that propolis ethanol extract can improve the humoral immune function of immunologic hypofunction mice, strengthen antibody forming cell's functional activity, improve the content of hemolysin, and can make it to recover normal level; Can strengthen HC and cause immunologic hypofunction mice M phagocytic function.So people claim that propolis is innate immune function promoter.
embodiment 10:
the above-mentioned soft capsule that can reduce blood glucose regulation insulin secretion, the chromium in described Rich chromium yeast can be corrected the impaired glucose tolerance that lacks chromium child and long-term parenteral patient, can effectively increase human muscle, reduces fat.Quantity research shows greatly, and in body, trivalent chromium can cause sugar, disorders of lipid metabolism, and human body chromium deficiency is closely related with the generation of diabetes and complication thereof.Think that the mechanism of action of chromium is can increase the disorderly adhesion with receptor of islets of langerhans, increase the disorderly acceptor quantity of islets of langerhans, increase the phosphorylation etc. of the disorderly receptor of islets of langerhans.In addition, take in, glucose oxidase becomes CO at the glucose of body: and glucose is converted to the aspects such as fat, and relying in islets of langerhans disorderly sugar, protein and lipid metabolism, chromium is mainly that islets of langerhans is disorderly plays a role in assistance.The natural low-molecular-weight chromium binding substance matter (Low molecular weight chromium bindingsubstance, LMWCr) of finding is regulating the effect of islets of langerhans aspect disorderly to be familiar with gradually by people.Chromium can activate the activity of the disorderly receptor kinase of islets of langerhans (insulin eceptor kinase), under the disorderly existence of islets of langerhans, LMWC ,-can stimulate kinase activity to increase by 8 times, and by chromium from wherein separating, will make its effect that increases enzymatic activity disappear.Chromium also can suppress phosphorylation tyrosine-phosphatase (Phosphotyrosine phosphatase), and this enzyme can reduce the activity of the disorderly receptor of islets of langerhans.The activation of chromium to the disorderly receptor kinase of islets of langerhans and cause the phosphorylation increase of the disorderly receptor of islets of langerhans and the disorderly sensitivity of islets of langerhans to strengthen to the inhibitory action of the disorderly receptor tyrosine phosphate of islets of langerhans.Recommending in the world chromium picked-up every day standard is 50-200 microgram.Research shows, chromium supplement is all effective to treating dissimilar sugar disease (comprising diabetes that type 2 diabetes mellitus, type 1 diabetes, gestational diabetes and steroid cause etc.).Diabetes patient exists and lacks chromium state.Use the effect of organic chromium better than inorganic chromium, the machine chromium of common are has chromium picolinate, nicotinic acid chromium, yeast chromium etc.As the biologically active agents of micro elements needed by human chromium, yeast chromium not only has good blood sugar lowering, the effect of blood fat reducing, can also avoid the toxicity of inorganic chromate salt, regulate human body sugar, lipid and protein metabolism, be safely a kind of and efficient chromium supplement.As can be seen here, yeast chromium will obtain applying more widely from now on.
yeast chromium contains natural organic active chromium; except can significantly reducing diabetes patient's blood glucose and the TC of hyperlipidemia patient, TG and LDL2C; can also improve HDL2C prevention medicated porridge sample arteriosclerosis; protection cardiac muscle; improve carbohydrate metabolism, lipid metabolism and the protein synthesis of human body; maintain the tertiary structure of nucleic acid, prevent the RNA Denaturation causing of being heated, prevention around or central nervous system there is pathological change.Yeast chromium both can be used as the medicine for the treatment of disease, was again a kind of good prevention and health care product.In addition, according to domestic and international relevant report, supplementary yeast chromium also has good fat-reducing effect, can be used as health slimming food of new generation.
people's clinical trial is found: take chromium yeast not only to reducing type ii diabetes people to external source insulin requirement with to outside type ii diabetes people blood sugar lowering, patients with coronary heart disease T-CHOL reduces by 10%, high density lipid (HDL) significantly increases 14%, and T-CHOL and high density lipid ratio reduce approximately 17%.In food, add high chromium yeast and can prevent and control the generation of arteriosclerosis symptom.Scarce chromium is also the pathogenic factor of arteriosclerosis disease.
embodiment 11:
the soft capsule that can reduce blood glucose regulation insulin secretion described in above-described embodiment, the main supplementary material of the prepared soft capsule that can reduce blood glucose regulation insulin secretion of above-described embodiment is Radix Panacis Quinquefolii extract, Fructus Momordicae charantiae extract, Folium Mori extract, propolis powder, Rich chromium yeast, soybean oil, Cera Flava, gelatin, glycerol, purified water, red yeast rice, have and obviously fall Zhi blood glucose, adjusting insulin secretion, serum cholesterol level, alleviate the health care of arteriosclerosis symptom; Chromium in Rich chromium yeast has the efficacy effect of definite nutrition patient's impaired glucose tolerance; propolis powder, Rich chromium yeast have auxiliary protection function; the suitable crowd of health food that health care is " fall Zhi blood glucose, regulate insulin secretion solution " is for " auxiliary treatment, diabetes and hyperlipidemia complications disease, diabetic neuropathy and the complication of impaired glucose tolerance crowd, senile diabetes crowd, type 2 diabetes mellitus and High-risk Group of Diabetes, type 1 diabetes, cardiovascular and cerebrovascular disease crowd's auxiliary treatment have more the health-caring function of normal population.
embodiment 12:
the soft capsule that can reduce blood glucose regulation insulin secretion described in above-described embodiment, the capsule shells composition of the prepared soft capsule that can reduce blood glucose regulation insulin secretion of above-described embodiment is by gelatin, glycerol, pure water, red yeast rice synthesizes, wherein gelatin is a kind of using by the animal bone boiling, the peptide molecule polymeric material that skin and muscle tendon are made, it is the hydrolyzate of collagenic protein, contain a large amount of aminoacid, there is higher nutritive value, burnt sugar coloring with food stage saccharide as glucose, fructose, sucrose, Nulomoline, maltose syrup, corn syrup, molasses, glucidtemnss etc. are raw material, more than 121 DEG C, heating under high temperature (or pressurization) makes it coking, and further process and make, human body is safe from harm.
Claims (5)
1. one kind can be reduced the soft capsule of blood glucose regulation insulin secretion, its composition comprises: capsule shells, in described capsule shells, there is content, it is characterized in that: described content comprises that parts by weight are the Radix Panacis Quinquefolii extract of 70-80, the Fructus Momordicae charantiae extract that parts by weight are 70-80, the Folium Mori extract that parts by weight are 90-110, the peak rubber powder that parts by weight are 50-60, the Rich chromium yeast that parts by weight are 9-13, the soybean oil that parts by weight are 440-455, the peak wax that parts by weight are 30-40; Described capsule shells comprises that parts by weight are the gelatin of 280-320, the glycerol that parts by weight are 120-130, the purified water that parts by weight are 270-330, the red yeast rice that parts by weight are 7-11.
2. the soft capsule that can reduce blood glucose regulation insulin secretion according to claim 1, is characterized in that: described content comprises that parts by weight are 70 Radix Panacis Quinquefolii extract, the Fructus Momordicae charantiae extract that parts by weight are 70, the Folium Mori extract that parts by weight are 90, the peak rubber powder that parts by weight are 50, the Rich chromium yeast that parts by weight are 9, the soybean oil that parts by weight are 440, the peak wax that parts by weight are 30; Described capsule shells comprises that parts by weight are 280 gelatin, the glycerol that parts by weight are 120, the purified water that parts by weight are 270, the red yeast rice that parts by weight are 7.
3. the soft capsule that can reduce blood glucose regulation insulin secretion according to claim 1 and 2, is characterized in that: described content comprises that parts by weight are 80 Radix Panacis Quinquefolii extract, the Fructus Momordicae charantiae extract that parts by weight are 80, the Folium Mori extract that parts by weight are 110, the peak rubber powder that parts by weight are 60, the Rich chromium yeast that parts by weight are 13, the soybean oil that parts by weight are 455, the peak wax that parts by weight are 40; Described capsule shells comprises that parts by weight are 320 gelatin, the glycerol that parts by weight are 130, the purified water that parts by weight are 330, the red yeast rice that parts by weight are 11.
4. the soft capsule that can reduce blood glucose regulation insulin secretion according to claim 1 and 2, is characterized in that: described content comprises that parts by weight are 75 Radix Panacis Quinquefolii extract, the Fructus Momordicae charantiae extract that parts by weight are 75, the Folium Mori extract that parts by weight are 100, the peak rubber powder that parts by weight are 55, the Rich chromium yeast that parts by weight are 11, the soybean oil that parts by weight are 448, the peak wax that parts by weight are 36; Described capsule shells comprises that parts by weight are 300 gelatin, the glycerol that parts by weight are 126, the purified water that parts by weight are 300, the red yeast rice that parts by weight are 9.
5. a manufacture method for the soft capsule that can reduce blood glucose regulation insulin secretion described in one of claim 1-4, is characterized in that: the method comprises the steps:
(1) processing of raw material: sieve, weigh: by Radix Panacis Quinquefolii extract, Fructus Momordicae charantiae extract, Folium Mori extract, cross 80 mesh sieves respectively, by above-mentioned parts by weight, accurately weighing, for subsequent use;
(2) batching: by Radix Panacis Quinquefolii extract, Fructus Momordicae charantiae extract, Folium Mori extract, mix homogeneously 20min,
Obtain mixture; When soybean oil is heated to 75 DEG C, add Cera Flava, stir melting 1h, obtain oily wax liquid, be cooled to 50 DEG C of insulations, stand-by; Peak rubber powder, Rich chromium yeast, mixture are added in oily wax liquid successively, and limit edged stirs, and 30min crosses colloidal grinding after mix homogeneously, emulsifying fineness 30 ~ 40 μ m, and the de-bubble to the greatest extent of-0.06 ~-0.08Mpa, obtains content stand-by;
(3) change glue: first will in purified water, putting into of glycerol glue tank, be heated to 70 DEG C, under stirring, gelatin, red yeast rice are slowly added, and continue to be heated to 70 DEG C, stirring boils 1h, de-bubbled-0.06 ~-0.08 Mpa, 65 ~ 70 DEG C, obtain glue, and 100 orders filter, at 60 DEG C, place 4 ~ 6h, for subsequent use;
(4) pelleting: start soft capsule press, compacting soft gelatin capsule, 18 ~ 22 DEG C of production environment temperature, rubber thickness 0.75 ~ 0.85, relative humidity 30 ~ 40%, controls loading amount 0.8g/ grain;
(5) sizing: the soft gelatin capsule suppressing is shaped in rotating cage with tape transport, 18 ~ 22 DEG C of temperature, relative humidity 30 ~ 40%, time 4h;
(6) wash ball, dry: clean soft gelatin capsule with 95% edible ethanol, until soft gelatin capsule any surface finish, bright, without grease, is then sent into soft gelatin capsule hothouse dry, control 24 ~ 26 DEG C of hothouse temperature, relative humidity 20 ~ 30%, dry 24h;
(7) lamp is picked up: dried soft capsule is placed on lamp inspection machine, and special messenger picks, and conscientiously checks soft capsule presentation quality, by empty pocket, special-shaped ball, flat ball, thin-walled ball, not of uniform sizely cause that ball, surface are untidy, bonding, distortion, leak capsule defective work and sort out;
(8) packaging: soft capsule is packed, and 120/bottle, oral solid drug adopts high-density polyethylene bottle.
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| CN104522658A (en) * | 2014-12-22 | 2015-04-22 | 威海百合生物技术股份有限公司 | Health food for reducing blood fat and blood sugar |
| CN105533688A (en) * | 2015-12-11 | 2016-05-04 | 山西宝山鼎盛科技有限公司 | Healthcare soft capsule with assistant blood-sugar reducing effect and preparation method thereof |
| CN105796649A (en) * | 2014-12-31 | 2016-07-27 | 天津中新药业研究中心 | Hypoglycemic composition and preparation method thereof |
| CN105796651A (en) * | 2014-12-31 | 2016-07-27 | 天津中新药业研究中心 | Composition capable of reducing blood glucose and preparation method |
| CN105796650A (en) * | 2014-12-31 | 2016-07-27 | 天津中新药业研究中心 | Hypoglycemic composition and preparation method thereof |
| CN106551058A (en) * | 2016-12-01 | 2017-04-05 | 广东省农业科学院蚕业与农产品加工研究所 | A kind of preparation method of blood sugar lowering Folium Mori tea |
| CN107095974A (en) * | 2017-06-01 | 2017-08-29 | 中山大学 | A kind of hypoglycemic composition |
| CN107335052A (en) * | 2017-05-31 | 2017-11-10 | 武汉和格生物技术有限公司 | For treating the formulation product of diabetes |
| CN108392519A (en) * | 2018-05-08 | 2018-08-14 | 上海紫石生物科技有限公司 | A kind of hypoglycemic composition and its preparation and application |
| CN109222029A (en) * | 2018-09-10 | 2019-01-18 | 福建省神六保健食品有限公司 | A kind of bee glue bitter gourd mulberry leaf soft capsule and preparation method thereof |
| WO2020113488A1 (en) * | 2018-12-06 | 2020-06-11 | 江苏安惠生物科技有限公司 | Granule having auxiliary hypoglycemic function |
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| CN114558051A (en) * | 2022-03-14 | 2022-05-31 | 北京瑞草科技有限公司 | Chinese medicinal composition for treating diabetes and preparation method thereof |
| CN116173117A (en) * | 2022-08-22 | 2023-05-30 | 哈尔滨顺亿堂医药生物科技开发有限公司 | Traditional Chinese medicine composition for assisting in reducing blood sugar and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101953466A (en) * | 2009-07-14 | 2011-01-26 | 博辉生物药业(深圳)有限公司 | Pearl and grape seed soft capsule |
-
2014
- 2014-08-20 CN CN201410411302.8A patent/CN104147132A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101953466A (en) * | 2009-07-14 | 2011-01-26 | 博辉生物药业(深圳)有限公司 | Pearl and grape seed soft capsule |
Non-Patent Citations (1)
| Title |
|---|
| 郭建生等主编: "《保健品与亚健康》", 31 May 2009, 中国中医药出版社 * |
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| CN104522658A (en) * | 2014-12-22 | 2015-04-22 | 威海百合生物技术股份有限公司 | Health food for reducing blood fat and blood sugar |
| CN105796649A (en) * | 2014-12-31 | 2016-07-27 | 天津中新药业研究中心 | Hypoglycemic composition and preparation method thereof |
| CN105796651A (en) * | 2014-12-31 | 2016-07-27 | 天津中新药业研究中心 | Composition capable of reducing blood glucose and preparation method |
| CN105796650A (en) * | 2014-12-31 | 2016-07-27 | 天津中新药业研究中心 | Hypoglycemic composition and preparation method thereof |
| CN105533688A (en) * | 2015-12-11 | 2016-05-04 | 山西宝山鼎盛科技有限公司 | Healthcare soft capsule with assistant blood-sugar reducing effect and preparation method thereof |
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| CN107335052A (en) * | 2017-05-31 | 2017-11-10 | 武汉和格生物技术有限公司 | For treating the formulation product of diabetes |
| CN107095974A (en) * | 2017-06-01 | 2017-08-29 | 中山大学 | A kind of hypoglycemic composition |
| CN108392519A (en) * | 2018-05-08 | 2018-08-14 | 上海紫石生物科技有限公司 | A kind of hypoglycemic composition and its preparation and application |
| CN109222029A (en) * | 2018-09-10 | 2019-01-18 | 福建省神六保健食品有限公司 | A kind of bee glue bitter gourd mulberry leaf soft capsule and preparation method thereof |
| WO2020113488A1 (en) * | 2018-12-06 | 2020-06-11 | 江苏安惠生物科技有限公司 | Granule having auxiliary hypoglycemic function |
| CN114027382A (en) * | 2021-11-04 | 2022-02-11 | 宝健（北京）生物技术有限公司 | A gel candy jelly liquid containing natural pigment, and its preparation method and application |
| CN114027382B (en) * | 2021-11-04 | 2024-03-19 | 宝健（北京）生物技术有限公司 | Gel candy glue solution containing natural pigment, preparation and application |
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Application publication date: 20141119 |
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| WD01 | Invention patent application deemed withdrawn after publication |