CN105796650A - Hypoglycemic composition and preparation method thereof - Google Patents
Hypoglycemic composition and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a hypoglycemic composition and a preparation method thereof and belongs to the field of health foods. The hypoglycemic composition is prepared from mulberry leaves and American ginseng. The hypoglycemic composition is reasonable and simple, has a small dosage, realizes blood sugar reduction and human body glycometabolism balance adjustment, can smooth reduce blood sugar and has substantial effects.
Description
Technical field
The present invention relates to a kind of compound for reducing blood suger and preparation method, belong to field of health care food.
Background technology
Diabetes have become global healthcare problem, there is no the effective ways curing diabetes at present, so controlling blood sugar level is prevention and the key alleviating diabetes harm.Diabetes are a kind of chronic, lifelong disease, need to control blood glucose throughout one's life, this be accomplished by Related product safely, effectively, be suitable for long-term taking.Owing to present diabetics is numerous, the exploitation for assistant hypoglycemia healthcare food has been provided with significantly high maturity.The health food being currently used for regulating blood glucose mainly has following a few class:
Containing flavone, alkaloids article: the blood sugar concentration of diabetics can be reduced, improve the bioactive ingredients of its symptom.As: Folium Mori, propolis, Radix Et Rhizoma Fagopyri Tatarici etc..
Containing saponins article: regulate insulin secretion, promote carbohydrate metabolism and lipid metabolism.Wherein represent and have Radix Panacis Quinquefolii, japanese angelica tree, Semen sojae atricolor, Fructus Momordicae, Punica granatum L., Poria, Herba Spinaciae etc..
Containing polysaccharide article: have now been found that various plants polysaccharide can reduce greatly blood glucose, modal such as polygonatum polysaccharide, ganoderan, Tea Polysaccharides, laminarin, SKGM, squash polyoses.
Current blood sugar lowering class health food mostly is above-mentioned medicinal substances extract and forms alone or in combination, and dose is big, and hypoglycemic effect is inconspicuous.
Summary of the invention
First technical problem that the invention solves the problems that is to provide a kind of compound for reducing blood suger.
The preparation method that another technical problem that the invention solves the problems that is to provide above-mentioned compound for reducing blood suger.
For achieving the above object, the present invention is by the following technical solutions:
A kind of compound for reducing blood suger, active component is made up of the raw material of following parts by weight: Radix Panacis Quinquefolii 1 part-30 parts, 1 part-30 parts of Folium Mori, L-arabinose 1 part-100 parts.
Described active component is preferably made up of the raw material of following parts by weight: Radix Panacis Quinquefolii 1 part-10 parts, Folium Mori 1-part-10 parts, L-arabinose 20 parts-70 parts.
Described active component is most preferably made up of the raw material of following parts by weight: Radix Panacis Quinquefolii 20 parts, 20 parts of Folium Mori, L-arabinose 50 parts.
Radix Panacis Quinquefolii, also known as panacis quinquefolii radix, Radix Panacis Quinquefolii, has boosting qi and nourishing yin, effect of clearing away heat and promoting production of body fluid, and for deficiency of vital energy yin deficiency, interior-heat, cough with asthma expectorant blood, deficiency-heat is tired of tired, quenches one's thirst, dryness of the mouth and throat.Radix Panacis Quinquefolii has the effect of resisting fatigue, antioxidation, suppression platelet aggregation, reduction blood coagulability, and Radix Panacis Quinquefolii can regulate insulin secretion, promote carbohydrate metabolism and lipid metabolism, affects carbohydate metabolism from many aspects, plays the effect of collaborative assisting in reducing blood sugar.
Folium Mori are the dried leaves of Moraceae (Moraceae) plant Mulberry (MorusalbaL), bitter in the mouth, sweet, cold in nature, return lung, Liver Channel, have dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, effect of liver heat removing and eyesight improving.
L-arabinose, also known as Arabinose, pectose, is a kind of aldopentose, it is possible to affecting the activity of human body hydrolysis disaccharidase, stoping excessive sucrose to be taken in, thus reducing blood glucose effect.It can suppress the enzyme of hydrolysis disaccharidase, therefore suppresses the blood glucose caused because taking in sucrose (resolve into glucose and fructose under the effect of small intestinal saccharase and absorbed) to raise.
In the present invention, L-arabinose suppresses the absorption of sucrose, and Radix Panacis Quinquefolii can regulate insulin secretion, promote carbohydrate metabolism and lipid metabolism.Folium Mori have suppression blood glucose to rise, reduce cholesterol, suppress body fat accumulation, maintain and salubrious effect, and several raw materials cooperate, comprehensive reduction blood sugar concentration.
The present invention not only prescription is simplified, and for the characteristic of raw medicinal material, by the extraction process of science, obtains the active component with definite curative effect.
Described active component is adopted and is prepared with the following method: weigh each raw material by proportioning raw materials, standby；Radix Panacis Quinquefolii water extraction 1-3 time of 6-12 times amount, each 1-3 hour, united extraction liquid, concentration, concentrated solution crosses D101 macroporous resin, is the ethanol elution of 30-90% with concentration of volume percent, it is 1.05-1.30 that eluent is concentrated under 50-60 DEG C of condition relative density, obtains concentrated solution A；Ethanol extraction 1-3 time that Folium Mori are 30-90% with the concentration of volume percent of 4-12 times amount, each 1-3 hour, united extraction liquid, being concentrated under 50-60 DEG C of condition relative density was 1.05-1.30, obtains concentrated solution B；Concentrated solution A, B are separately dried, and obtain dried object I, II；Dried object I, II are mixed homogeneously with L-arabinose, obtain dried object III；Dried object III, is active component.
Described active component preferably employs following method to be prepared: weigh each raw material by proportioning raw materials, standby；Radix Panacis Quinquefolii water extraction 2-3 time of 8-10 times amount, each 1-2 hour, united extraction liquid, concentration, concentrated solution crosses D101 macroporous resin, is the ethanol elution of 40-80% with concentration of volume percent, it is 1.10-1.20 that eluent is concentrated under 50-60 DEG C of condition relative density, obtains concentrated solution A；Ethanol extraction 2-3 time that Folium Mori are 40-80% with the concentration of volume percent of 6-10 times amount, each 1-2 hour, united extraction liquid, being concentrated under 50-60 DEG C of condition relative density was 1.10-1.20, obtains concentrated solution B；Concentrated solution A, B are separately dried, and obtain dried object I, II；Dried object I, II are mixed homogeneously with L-arabinose, obtain dried object III；Dried object III, is active component.
Described compound for reducing blood suger is possibly together with adjuvant.
Described adjuvant is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid, sorbitol, xylitol and sodium sulfite.
Described compound for reducing blood suger is granule, powder, tablet, capsule or oral liquid.
A kind of preparation method of compound for reducing blood suger, each raw material is weighed by proportioning raw materials, standby, wherein Radix Panacis Quinquefolii 1 part-30 parts, 1 part-30 parts of Folium Mori, L-arabinose 1 part-100 parts, it is preferable that Radix Panacis Quinquefolii 1 part-10 parts, Folium Mori 1-part-10 parts, L-arabinose 20 parts-70 parts, most preferably Radix Panacis Quinquefolii 20 parts, 20 parts of Folium Mori, L-arabinose 50 parts；Radix Panacis Quinquefolii water extraction 1-3 time of 6-12 times amount, each 1-3 hour, united extraction liquid, concentration, concentrated solution crosses D101 macroporous resin, is the ethanol elution of 30-90% with concentration of volume percent, it is 1.05-1.30 that eluent is concentrated under 50-60 DEG C of condition relative density, obtains concentrated solution A；Ethanol extraction 1-3 time that Folium Mori are 30-90% with the concentration of volume percent of 4-12 times amount, each 1-3 hour, united extraction liquid, being concentrated under 50-60 DEG C of condition relative density was 1.05-1.30, obtains concentrated solution B；Concentrated solution A, B are separately dried, and obtain dried object I, II；Dried object I, II are mixed homogeneously with L-arabinose, obtain dried object III；Dried object III, is active component.
Preferred preparation method is: weigh each raw material by proportioning raw materials, standby；Radix Panacis Quinquefolii water extraction 2-3 time of 8-10 times amount, each 1-2 hour, united extraction liquid, concentration, concentrated solution crosses D101 macroporous resin, is the ethanol elution of 40-80% with concentration of volume percent, it is 1.10-1.20 that eluent is concentrated under 50-60 DEG C of condition relative density, obtains concentrated solution A；Ethanol extraction 2-3 time that Folium Mori are 40-80% with the concentration of volume percent of 6-10 times amount, each 1-2 hour, united extraction liquid, being concentrated under 50-60 DEG C of condition relative density was 1.10-1.20, obtains concentrated solution B；Concentrated solution A, B are separately dried, and obtain dried object I, II；Dried object I, II are mixed homogeneously with L-arabinose, obtain dried object III；Dried object III, is active component.
Compound for reducing blood suger involved by technical solution of the present invention and preparation thereof are respectively provided with and good drop hypoglycemic effect.
The invention have the advantage that reasonable recipe, simplify, dose is little, takes into account blood sugar lowering and regulates body carbohydrate metabolism balance, and blood sugar lowering is mild, and effect is notable.
Describe technical solution of the present invention by the following examples in detail, do not limit the practical range of the present invention with this.
Detailed description of the invention
Embodiment 1:
One. prescription:
Radix Panacis Quinquefolii 200g, Folium Mori 200g, L-arabinose 500g
Two. method for making:
Each raw material is weighed by proportioning raw materials, standby；The Radix Panacis Quinquefolii water extraction 3 times of 8 times amount, each 2 hours, united extraction liquid, concentration, concentrated solution crossed D101 macroporous resin, is the ethanol elution of 70% with concentration of volume percent, and it is 1.10 that eluent is concentrated under 50-60 DEG C of condition relative density, obtains concentrated solution A；The ethanol extraction 2 times that Folium Mori are 70% with concentration of volume percent, first time adds 8 times amount and extracts 2 hours, and second time adds 6 times amount and extracts 1.5 hours, united extraction liquid, and being concentrated under 50-60 DEG C of condition relative density is 1.10, obtains concentrated solution B；Concentrated solution A, B are separately dried, and obtain dried object I, II；Dried object I, II are mixed homogeneously with L-arabinose, obtain dried object III；Dried object III, is active component.Active component weight 550g.
Embodiment 2:
One. prescription:
Radix Panacis Quinquefolii 100g, Folium Mori 100g, L-arabinose 250g
Two. method for making:
Each raw material is weighed by proportioning raw materials, standby；Radix Panacis Quinquefolii water extraction 3 times, once add 10 times amount water extraction 2 hours, second and third time adds 8 times amount water extraction 1.5 hours, united extraction liquid, concentration, concentrated solution crosses D101 macroporous resin, is the ethanol elution of 60% with concentration of volume percent, it is 1.15 that eluent is concentrated under 50-60 DEG C of condition relative density, obtains concentrated solution A；The ethanol extraction 2 times that Folium Mori are 60% with the concentration of volume percent of 10 times amount, each 1.5 hours, united extraction liquid, being concentrated under 50-60 DEG C of condition relative density was 1.15, obtains concentrated solution B；Concentrated solution A, B are separately dried, and obtain dried object I, II；Dried object I, II are mixed homogeneously with L-arabinose, obtain dried object III；Dried object III, is active component.Active component weight 280g.
Embodiment 3:
One. prescription:
Radix Panacis Quinquefolii 100g, Folium Mori 100g, L-arabinose 100g.
Two. method for making:
Each raw material is weighed by proportioning raw materials, standby；The Radix Panacis Quinquefolii water extraction 3 times of 6 times amount, each 3 hours, united extraction liquid, concentration, concentrated solution crossed D101 macroporous resin, is the ethanol elution of 30% with concentration of volume percent, and it is 1.05 that eluent is concentrated under 50-60 DEG C of condition relative density, obtains concentrated solution A；The ethanol extraction 3 times that Folium Mori are 30% with the concentration of volume percent of 4 times amount, each 3 hours, united extraction liquid, being concentrated under 50-60 DEG C of condition relative density was 1.05, obtains concentrated solution B；Concentrated solution A, B are separately dried, and obtain dried object I, II；Dried object I, II are mixed homogeneously with L-arabinose, obtain dried object III；Dried object III, is active component.
Embodiment 4:
One. prescription:
Radix Panacis Quinquefolii 30g, Folium Mori 30g, L-arabinose 100g.
Two. method for making:
Each raw material is weighed by proportioning raw materials, standby；The Radix Panacis Quinquefolii water extraction 1 time of 12 times amount, 1 hour, concentration, concentrated solution crossed D101 macroporous resin, is the ethanol elution of 90% with concentration of volume percent, and it is 1.30 that eluent is concentrated under 50-60 DEG C of condition relative density, obtains concentrated solution A；The ethanol extraction 1 time that Folium Mori are 30% with the concentration of volume percent of 4 times amount, 3 hours, being concentrated under 50-60 DEG C of condition relative density was 1.30, obtains concentrated solution B；Concentrated solution A, B are separately dried, and obtain dried object I, II；Dried object I, II are mixed homogeneously with L-arabinose, obtain dried object III；Dried object III, is active component.
Embodiment 5:
One. prescription:
Radix Panacis Quinquefolii 10g, Folium Mori 10g, L-arabinose 200g.
Two. method for making:
Each raw material is weighed by proportioning raw materials, standby；The Radix Panacis Quinquefolii water extraction 2 times of 8 times amount, each 2 hours, united extraction liquid, concentration, concentrated solution crossed D101 macroporous resin, is the ethanol elution of 80% with concentration of volume percent, and it is 1.10 that eluent is concentrated under 50-60 DEG C of condition relative density, obtains concentrated solution A；The ethanol extraction 2 times that Folium Mori are 40% with the concentration of volume percent of 6 times amount, each 2 hours, united extraction liquid, being concentrated under 50-60 DEG C of condition relative density was 1.10, obtains concentrated solution B；Concentrated solution A, B are separately dried, and obtain dried object I, II；Dried object I, II are mixed homogeneously with L-arabinose, obtain dried object III；Dried object III, is active component.
Embodiment 6:
One. prescription:
Radix Panacis Quinquefolii 100g, Folium Mori 100g, L-arabinose 700g.
Two. method for making:
Each raw material is weighed by proportioning raw materials, standby；The Radix Panacis Quinquefolii water extraction 3 times of 10 times amount, each 2 hours, united extraction liquid, concentration, concentrated solution crossed D101 macroporous resin, is the ethanol elution of 60% with concentration of volume percent, and it is 1.14 that eluent is concentrated under 50-60 DEG C of condition relative density, obtains concentrated solution A；The ethanol extraction 3 times that Folium Mori are 60% with the concentration of volume percent of 10 times amount, each 2 hours, united extraction liquid, being concentrated under 50-60 DEG C of condition relative density was 1.14, obtains concentrated solution B；Concentrated solution A, B are separately dried, and obtain dried object I, II；Dried object I, II are mixed homogeneously with L-arabinose, obtain dried object III；Dried object III, is active component.
Embodiment 7:
One. prescription:
Radix Panacis Quinquefolii 50g, Folium Mori 50g, L-arabinose 400g.
Two. method for making:
Each raw material is weighed by proportioning raw materials, standby；The Radix Panacis Quinquefolii water extraction 2 times of 8 times amount, each 1.5 hours, united extraction liquid, concentration, concentrated solution crossed D101 macroporous resin, is the ethanol elution of 70% with concentration of volume percent, and it is 1.18 that eluent is concentrated under 50-60 DEG C of condition relative density, obtains concentrated solution A；The ethanol extraction 2 times that Folium Mori are 70% with the concentration of volume percent of 8 times amount, each 2 hours, united extraction liquid, being concentrated under 50-60 DEG C of condition relative density was 1.18, obtains concentrated solution B；Concentrated solution A, B are separately dried, and obtain dried object I, II；Dried object I, II are mixed homogeneously with L-arabinose, obtain dried object III；Dried object III, is active component.
Embodiment 8: prepare Jiantang Granule
The active component 550g that embodiment 1 obtains, adds sorbitol 20g, xylitol 30g, granulates, obtains granule, every packed 3g.
Embodiment 9: prepare blood sugar lowering tablet
Embodiment 2 obtains active component 280g, adds lactose 20g, granulates, and tabletting obtains tablet, every tablet weight 1.5g.
Embodiment 10: pharmacological evaluation
1. test material
1.1 laboratory animals:
ICR mice, male, SPF level, Beijing Vital River Experimental Animals Technology Co., Ltd. provides.
ZDF rat, male, SPF level, Beijing Vital River Experimental Animals Technology Co., Ltd. provides.
1.2 medicines and reagent:
Blood sugar lowering extract (is prepared by embodiment 1), Zhongxin Innova Laboratories.
Sucrose, Tianjin Kermel Chemical Reagent Co., Ltd..
L-arabinose, Tang Chuan bio tech ltd.
1.3 instruments:
Germany Roche (ROCHE) Luo Kang is remarkable type blood glucose meter and supporting Test paper entirely.
2. method and result
2.1 impacts that high glucose and high fat fed foster mice sucrose carbohydrate tolerance
Select healthy without hindering ICR mice, all male, feed high glucose and high fat feedstuff (formula: basestocks 60%, Adeps Sus domestica 10%, sucrose 10%, egg 10%, milk powder 5%, cholesterol 3%, Oleum sesami 2%), continuous 4 weeks.Tail vein blood, uses Roche blood glucose meter to measure blood glucose value, is 5 groups by blood glucose value equilibrium, often group 12, that is: matched group, L-arabinose group (3g/kg), blood sugar lowering extract (1.5,3,6g crude drug/kg) group, by body weight gastric infusion respectively, matched group gives equal-volume pure water, administration volume is 20ml/kg, continuous 3 weeks, and last is administered latter 1 hour, equal gavage sucrose solution (3g/kg), measures 0,0.5,2 hours blood glucose values.Adopt SPSS software to carry out one factor analysis of variance and data are carried out statistical procedures.Result of the test refers to table 1.
High glucose and high fat is fed the impact of mice sucrose carbohydrate tolerance by table 1 blood sugar lowering extract
Compared with matched group, * P < 0.05；**P<0.01
It is shown that 1.5g crude drug/kg of the present invention and above dosage blood sugar lowering extract can significantly inhibit Mouse oral sucrose after the increasing rapidly of blood glucose value, present significant dose-effect relationship trend.Prompting blood sugar lowering extract can pass through effectively to suppress the absorption of sucrose in high-carbonhydrate diet, reduces the pharmacological action of blood glucose.
2.2 impacts on Bb Wistar Rats With Spontaneous Diabetes (ZDF rat) blood glucose
Select ZDF rat, all male, feeding high lipid food (formula: basestocks 88%, refined lard 10%, cholesterol 2%).Tail vein blood, use Roche blood glucose meter to measure blood glucose value, be 5 groups by blood glucose value equilibrium, often group 10, that is: matched group, L-arabinose group, blood sugar lowering extract (1.5,3,6g crude drug/kg) group, by body weight gastric infusion respectively, matched group gives equal-volume pure water, administration volume is 10ml/kg, continuous 4 weeks, last measured blood glucose value after being administered latter 1 hour again.Adopt SPSS software to carry out one factor analysis of variance and data are carried out statistical procedures.Result of the test refers to table 2.
The impact on ZUCKER rat blood sugar of the table 2 blood sugar lowering extract
Compared with matched group, * P < 0.05；**P<0.01
It is shown that 1.5g crude drug/kg of the present invention and above dosage extract can significantly reduce the blood glucose value of Bb Wistar Rats With Spontaneous Diabetes, and present significant dose-effect relationship trend.Prompting blood sugar lowering extract has certain pharmacological action reducing by II diabetes glucose value.
Claims (10)
1. a compound for reducing blood suger, it is characterised in that active component is made up of the raw material of following parts by weight: Radix Panacis Quinquefolii 1 part-30 parts, 1 part-30 parts of Folium Mori, L-arabinose 1 part-100 parts.
2. a kind of compound for reducing blood suger according to claim 1, it is characterised in that active component is made up of the raw material of following parts by weight: Radix Panacis Quinquefolii 1 part-10 parts, Folium Mori 1-part-10 parts, L-arabinose 20 parts-70 parts.
3. a kind of compound for reducing blood suger according to claim 2, it is characterised in that active component is made up of the raw material of following parts by weight: Radix Panacis Quinquefolii 20 parts, 20 parts of Folium Mori, L-arabinose 50 parts.
4. a kind of compound for reducing blood suger in any of the one of claim 1-3, it is characterised in that described active component is adopted and prepared with the following method: weigh each raw material by proportioning raw materials, standby；Radix Panacis Quinquefolii water extraction 1-3 time of 6-12 times amount, each 1-3 hour, united extraction liquid, concentration, concentrated solution crosses D101 macroporous resin, is the ethanol elution of 30-90% with concentration of volume percent, it is 1.05-1.30 that eluent is concentrated under 50-60 DEG C of condition relative density, obtains concentrated solution A；Ethanol extraction 1-3 time that Folium Mori are 30-90% with the concentration of volume percent of 4-12 times amount, each 1-3 hour, united extraction liquid, being concentrated under 50-60 DEG C of condition relative density was 1.05-1.30, obtains concentrated solution B；Concentrated solution A, B are separately dried, and obtain dried object I, II；Dried object I, II are mixed homogeneously with L-arabinose, obtain dried object III；Dried object III, is active component.
5. a kind of compound for reducing blood suger according to claim 4, it is characterised in that described active component is adopted and prepared with the following method: weigh each raw material by proportioning raw materials, standby；Radix Panacis Quinquefolii water extraction 2-3 time of 8-10 times amount, each 1-2 hour, united extraction liquid, concentration, concentrated solution crosses D101 macroporous resin, is the ethanol elution of 40-80% with concentration of volume percent, it is 1.10-1.20 that eluent is concentrated under 50-60 DEG C of condition relative density, obtains concentrated solution A；Ethanol extraction 2-3 time that Folium Mori are 40-80% with the concentration of volume percent of 6-10 times amount, each 1-2 hour, united extraction liquid, being concentrated under 50-60 DEG C of condition relative density was 1.10-1.20, obtains concentrated solution B；Concentrated solution A, B are separately dried, and obtain dried object I, II；Dried object I, II are mixed homogeneously with L-arabinose, obtain dried object III；Dried object III, is active component.
6. a kind of compound for reducing blood suger in any of the one of claim 1-5, it is characterised in that: described compound for reducing blood suger is possibly together with adjuvant.
7. a kind of compound for reducing blood suger according to claim 6, it is characterised in that: described adjuvant is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid, sorbitol, xylitol and sodium sulfite.
8. a kind of compound for reducing blood suger according to claim 6, it is characterised in that: described compound for reducing blood suger is granule, powder, tablet, capsule or oral liquid.
9. the preparation method of the compound for reducing blood suger in any of the one of claim 1-3, it is characterised in that: weigh each raw material by proportioning raw materials, standby；Radix Panacis Quinquefolii water extraction 1-3 time of 6-12 times amount, each 1-3 hour, united extraction liquid, concentration, concentrated solution crosses D101 macroporous resin, is the ethanol elution of 30-90% with concentration of volume percent, it is 1.05-1.30 that eluent is concentrated under 50-60 DEG C of condition relative density, obtains concentrated solution A；Ethanol extraction 1-3 time that Folium Mori are 30-90% with the concentration of volume percent of 4-12 times amount, each 1-3 hour, united extraction liquid, being concentrated under 50-60 DEG C of condition relative density was 1.05-1.30, obtains concentrated solution B；Concentrated solution A, B are separately dried, and obtain dried object I, II；Dried object I, II are mixed homogeneously with L-arabinose, obtain dried object III；Dried object III, is active component.
10. the preparation method of compound for reducing blood suger according to claim 9, it is characterised in that: weigh each raw material by proportioning raw materials, standby；Radix Panacis Quinquefolii water extraction 2-3 time of 8-10 times amount, each 1-2 hour, united extraction liquid, concentration, concentrated solution crosses D101 macroporous resin, is the ethanol elution of 40-80% with concentration of volume percent, it is 1.10-1.20 that eluent is concentrated under 50-60 DEG C of condition relative density, obtains concentrated solution A；Ethanol extraction 2-3 time that Folium Mori are 40-80% with the concentration of volume percent of 6-10 times amount, each 1-2 hour, united extraction liquid, being concentrated under 50-60 DEG C of condition relative density was 1.10-1.20, obtains concentrated solution B；Concentrated solution A, B are separately dried, and obtain dried object I, II；Dried object I, II are mixed homogeneously with L-arabinose, obtain dried object III；Dried object III, is active component.
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| CN108713738A (en) * | 2018-04-17 | 2018-10-30 | 北京中和鸿业医药科技有限公司 | A kind of American Ginseng siberian solomonseal rhizome composition, preparation method, preparation and application |
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