CN105749199A - Traditional Chinese medicinal composition for warming middle warmer and invigorating spleen, and preparation method thereof - Google Patents
Traditional Chinese medicinal composition for warming middle warmer and invigorating spleen, and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal composition for warming middle warmer and invigorating spleen, and a preparation method thereof, and belongs to the field of traditional Chinese medicine modernization. Effective components of the traditional Chinese medicinal composition for warming middle warmer and invigorating spleen are prepared from aconite root and Radix Codonopsis. Compared with present commercial dosage forms, the composition disclosed in the invention has the advantages of stable and controllable quality, substantially improved curative effect, reduction of the taking dosage of patients, improved bioavailability, and substantial economic and social benefits.
Description
Technical field
The present invention relates to Chinese medicine composition of a kind of warming middle-JIAO and strengthening the spleen and preparation method thereof, belong to modern Chinese traditional medicine field.
Background technology
In Radix Aconiti Lateralis Preparata reason, liquid is the Chinese medicine of presently commercially available a kind of warming middle-JIAO and strengthening the spleen, and it is made up of Radix Aconiti Lateralis Preparata, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis and Radix Glycyrrhizae.Liquid warming middle-JIAO and strengthening the spleen in Radix Aconiti Lateralis Preparata reason, is used for treating Deficiency and coldness of spleen and stomach, coldness and pain in the epigastrium, and vomiting is had loose bowels, the disease of hands and feet being not warm.
In Radix Aconiti Lateralis Preparata reason, the method for making of liquid is: the above five tastes, is ground into coarse powder, Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis 85% alcohol dipping, diafiltration.Collecting percolate 182ml, the Rhizoma Atractylodis Macrocephalae, with 70% alcohol dipping percolation, collects percolate 78ml, merges percolate, reclaims ethanol, is concentrated into 26ml standby；Radix Salviae Miltiorrhizae, Radix Glycyrrhizae boiling twice, filter, collecting decoction, be concentrated into 260ml, standby, is merged by both the above concentrated solution, adjusts alcohol content, stands 7 days, Aspirate supernatant, place five days, takes supernatant and adjusts total amount to 650ml, shakes up, fill, to obtain final product.
This medicine treats that method for making is complicated, and man-hour is long, and final preparation alcohol content is higher, is about 25-28%, is unfavorable for that patient takes, it is therefore necessary to its preparation technology is improved, and is desirably to obtain in Radix Aconiti Lateralis Preparata reason the modernization Chinese medicine preparation of liquid.But much studying discovery, some traditional Chinese medicine compositions are after using modern pharmaceutical technique refining, and under the premise that crude drug amount is constant, the more former medicine of its curative effect has decline in various degree, this is because traditional handicraft often contains more ingredient.In Radix Aconiti Lateralis Preparata reason, the prescription of liquid is complicated, and containing gomi herbs, its factor affected the treatment is a lot, adds difficulty for process optimization.
Summary of the invention
First technical problem that the invention solves the problems that is to provide the Chinese medicine composition of a kind of warming middle-JIAO and strengthening the spleen.
The preparation method that another technical problem that the invention solves the problems that is to provide said medicine.
For achieving the above object, the present invention is by the following technical solutions:
The Chinese medicine composition of a kind of warming middle-JIAO and strengthening the spleen, its effective ingredient is made up of the raw material of following parts by weight: Radix Aconiti Lateralis Preparata (system) 100 parts, Radix Codonopsis 200 parts, the Rhizoma Atractylodis Macrocephalae (stir-fry) 150 parts, Rhizoma Zingiberis 100 parts, 100 parts of Radix Glycyrrhizae.
Described effective ingredient adopts following method to prepare: weigh each raw material by proportioning raw materials, standby；The whole flavour of a drug of prescription were with 6-12 times amount water extraction 4-10 hour and collected volatile oil, and it is 1.20-1.35 that extracting solution is concentrated under 50-60 DEG C of condition relative density, obtains concentrated solution A, obtains volatile oil B simultaneously；Concentrated solution A is dried, obtains dried object I；Volatile oil B and dried object I is merged, obtains dried object II；Dried object II, is effective ingredient.
Described effective ingredient adopts following method to prepare: the whole flavour of a drug of prescription were with 8-10 times amount water extraction 6-8 hour and collected volatile oil, and it is 1.25-1.30 that extracting solution is concentrated under 50-60 DEG C of condition relative density, obtains concentrated solution A, obtains volatile oil B simultaneously；Concentrated solution A is dried, obtains dried object I；Volatile oil B and dried object I is merged, obtains dried object II；Dried object II, is effective ingredient.
Described effective ingredient adopts following method to prepare: the whole flavour of a drug of prescription were with 10 times amount water extraction 6 hours and collected volatile oil, and it is 1.25 that extracting solution is concentrated under 50-60 DEG C of condition relative density, obtains concentrated solution A, obtains volatile oil B simultaneously；Concentrated solution A is dried, obtains dried object I；Volatile oil B and dried object I is merged, obtains dried object II；Dried object II, is effective ingredient.
Described Chinese medicine composition is possibly together with the acceptable adjuvant of pharmaceutics.
The acceptable adjuvant of described pharmaceutics is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and sodium sulfite.
The dosage form of described Chinese medicine composition is pill, tablet, capsule or oral liquid.The selection of dosage form and the consumption of adjuvant belong to prior art.
The preparation method of the Chinese medicine composition of a kind of warming middle-JIAO and strengthening the spleen, weighs Radix Aconiti Lateralis Preparata (system) 100 parts, Radix Codonopsis 200 parts, the Rhizoma Atractylodis Macrocephalae (stir-fry) 150 parts, Rhizoma Zingiberis 100 parts, 100 parts of Radix Glycyrrhizae；The whole flavour of a drug of prescription were with 6-12 times amount water extraction 4-10 hour and collected volatile oil, and it is 1.20-1.35 that extracting solution is concentrated under 50-60 DEG C of condition relative density, obtains concentrated solution A, obtains volatile oil B simultaneously；Concentrated solution A is dried, obtains dried object I；Volatile oil B and dried object I is merged, obtains dried object II；Dried object II, is effective ingredient.
Preferred method for making is: the whole flavour of a drug of described prescription were with 8-10 times amount water extraction 6-8 hour and collected volatile oil, and it is 1.25-1.30 that extracting solution is concentrated under 50-60 DEG C of condition relative density, obtains concentrated solution A, obtains volatile oil B simultaneously；Concentrated solution A is dried, obtains dried object I；Volatile oil B and dried object I is merged, obtains dried object II；Dried object II, is effective ingredient.
Most preferred method for making is: the whole flavour of a drug of described prescription were with 10 times amount water extraction 6 hours and collected volatile oil, and it is 1.25 that extracting solution is concentrated under 50-60 DEG C of condition relative density, obtains concentrated solution A, obtains volatile oil B simultaneously；Concentrated solution A is dried, obtains dried object I；Volatile oil B and dried object I is merged, obtains dried object II；Dried object II, is effective ingredient.
Chinese medicine composition and preparation thereof involved by technical solution of the present invention are respectively provided with good warming middle-JIAO and strengthening the spleen effect, can be used for treating Deficiency and coldness of spleen and stomach, coldness and pain in the epigastrium, and vomiting is had loose bowels, the disease of hands and feet being not warm.Results of animal shows, pharmaceutical composition prepared by present invention process, compared with former dosage form, has more excellent analgesic activity.
The invention have the advantage that the present invention uses theory of Chinese medical science to analyze prescription composition, the result of study of the physicochemical property according to each flavour of a drug ingredient and pharmacological action, the preparation method that research obtains reasonable, stable effective ingredient, greatly shorten man-hour, and preparation is without ethanol, it is simple to patient takes.Adopt technical solution of the present invention, prepared pharmaceutical preparation stable and controllable for quality, that curative effect significantly improves compared with existing commercial dosage forms, patient's taking dose reduces, bioavailability improves, there is significant economic and social benefit.
Describe technical solution of the present invention by the following examples in detail, do not limit the practical range of the present invention with this.
Detailed description of the invention
Embodiment 1: prepare Chinese medicine extract
One. prescription:
Radix Aconiti Lateralis Preparata (system) the 200g Radix Codonopsis 400g Rhizoma Atractylodis Macrocephalae (stir-fry) 300g Rhizoma Zingiberis 200g Radix Glycyrrhizae 200g
Two. method for making:
The whole flavour of a drug of prescription were with 10 times amount water extraction 6 hours and collected volatile oil, and it is 1.25 that extracting solution is concentrated under 50-60 DEG C of condition relative density, obtains concentrated solution A, obtains volatile oil B simultaneously；Concentrated solution A is dried, obtains dried object I；Volatile oil B and dried object I is merged, obtains dried object II；Dried object II, is effective ingredient.The amount of effective ingredient is 580 grams.
Embodiment 2: prepare Chinese medicine extract
One. prescription:
Radix Aconiti Lateralis Preparata (system) the 100g Radix Codonopsis 200g Rhizoma Atractylodis Macrocephalae (stir-fry) 150g Rhizoma Zingiberis 100g Radix Glycyrrhizae 100g
Two. method for making:
The whole flavour of a drug of prescription were with 12 times amount water extraction 7 hours and collected volatile oil, and it is 1.20 that extracting solution is concentrated under 50-60 DEG C of condition relative density, obtains concentrated solution A, obtains volatile oil B simultaneously；Concentrated solution A is dried, obtains dried object I；Volatile oil B and dried object I is merged, obtains dried object II；Dried object II, is effective ingredient.The amount of effective ingredient is 280 grams.
Embodiment 3: prepare Chinese medicine extract
One. prescription:
Radix Aconiti Lateralis Preparata (system) the 100g Radix Codonopsis 200g Rhizoma Atractylodis Macrocephalae (stir-fry) 150g Rhizoma Zingiberis 100g Radix Glycyrrhizae 100g
Two. method for making:
Each raw material is weighed by proportioning raw materials, standby；The whole flavour of a drug of prescription were with 6 times amount water extraction 4 hours and collected volatile oil, and it is 1.35 that extracting solution is concentrated under 50-60 DEG C of condition relative density, obtains concentrated solution A, obtains volatile oil B simultaneously；Concentrated solution A is dried, obtains dried object I；Volatile oil B and dried object I is merged, obtains dried object II；Dried object II, is effective ingredient.
Embodiment 4: prepare Chinese medicine extract
One. prescription:
Radix Aconiti Lateralis Preparata (system) the 100g Radix Codonopsis 200g Rhizoma Atractylodis Macrocephalae (stir-fry) 150g Rhizoma Zingiberis 100g Radix Glycyrrhizae 100g
Two. method for making:
Each raw material is weighed by proportioning raw materials, standby；The whole flavour of a drug of prescription were with 7 times amount water extraction 5 hours and collected volatile oil, and it is 1.23 that extracting solution is concentrated under 50-60 DEG C of condition relative density, obtains concentrated solution A, obtains volatile oil B simultaneously；Concentrated solution A is dried, obtains dried object I；Volatile oil B and dried object I is merged, obtains dried object II；Dried object II, is effective ingredient.
Embodiment 5: prepare Chinese medicine extract
One. prescription:
Radix Aconiti Lateralis Preparata (system) the 100g Radix Codonopsis 200g Rhizoma Atractylodis Macrocephalae (stir-fry) 150g Rhizoma Zingiberis 100g Radix Glycyrrhizae 100g
Two. method for making:
Each raw material is weighed by proportioning raw materials, standby；The whole flavour of a drug of prescription were with 8 times amount water extraction 7 hours and collected volatile oil, and it is 1.26 that extracting solution is concentrated under 50-60 DEG C of condition relative density, obtains concentrated solution A, obtains volatile oil B simultaneously；Concentrated solution A is dried, obtains dried object I；Volatile oil B and dried object I is merged, obtains dried object II；Dried object II, is effective ingredient.
Embodiment 6: prepare Chinese medicine extract
One. prescription:
Radix Aconiti Lateralis Preparata (system) the 100g Radix Codonopsis 200g Rhizoma Atractylodis Macrocephalae (stir-fry) 150g Rhizoma Zingiberis 100g Radix Glycyrrhizae 100g
Two. method for making:
Each raw material is weighed by proportioning raw materials, standby；The whole flavour of a drug of prescription were with 9 times amount water extraction 8 hours and collected volatile oil, and it is 1.32 that extracting solution is concentrated under 50-60 DEG C of condition relative density, obtains concentrated solution A, obtains volatile oil B simultaneously；Concentrated solution A is dried, obtains dried object I；Volatile oil B and dried object I is merged, obtains dried object II；Dried object II, is effective ingredient.
Embodiment 7: prepare Chinese medicine extract
One. prescription:
Radix Aconiti Lateralis Preparata (system) the 100g Radix Codonopsis 200g Rhizoma Atractylodis Macrocephalae (stir-fry) 150g Rhizoma Zingiberis 100g Radix Glycyrrhizae 100g
Two. method for making:
Each raw material is weighed by proportioning raw materials, standby；The whole flavour of a drug of prescription were with 11 times amount water extraction 10 hours and collected volatile oil, and it is 1.25 that extracting solution is concentrated under 50-60 DEG C of condition relative density, obtains concentrated solution A, obtains volatile oil B simultaneously；Concentrated solution A is dried, obtains dried object I；Volatile oil B and dried object I is merged, obtains dried object II；Dried object II, is effective ingredient.
Embodiment 8: prepare tablet
The effective ingredient 580g that embodiment 1 obtains, adds microcrystalline Cellulose 200g, lactose 100g, cross-linked pvp 20g, tabletting, obtains tablet, and every is 0.45g.
Embodiment 9: prepare capsule
The effective ingredient 280g that embodiment 2 obtains, adds starch 120g, granule processed, encapsulating capsule, obtains capsule, and every is 0.40g.
Embodiment 10: the impact of the mouse writhing reaction that extract Dichlorodiphenyl Acetate causes
One. test material
1. laboratory animal
ICR mice, male and female half and half, Beijing Vital River Experimental Animals Technology Co., Ltd..
2. medicine and reagent
Liquid in Radix Aconiti Lateralis Preparata reason, extract (preparing according to embodiment 1 method) in Radix Aconiti Lateralis Preparata reason, Lerentang Pharmaceutical Factory, Zhongxin Pharmaceutical Group Co., Ltd., Tianj.
Aspirin effervescent tablets, specification is 0.1g/ sheet, AstraZeneca pharmaceutical Co. Ltd.
Sodium carboxymethyl cellulose, Chemical Reagent Co., Ltd., Sinopharm Group.
Glacial acetic acid, Chemical Reagent Co., Ltd., Sinopharm Group.
Two. test method
Take ICR mice, male and female half and half, 6 groups are divided by body weight equilibrium, matched group, positive group (aspirin 0.3g/kg), liquid group (4 crude drug g/kg) in Radix Aconiti Lateralis Preparata reason, extract is low, in, high dose group (2, 4, 8 crude drug g/kg, prepare according to embodiment 1 method), continuous gastric infusion 7 days, positive group was administered 1 time in test the same day, matched group gives equal-volume pure water, administration volume is 20ml/kg, fasting more than 12 hours before experiment, last is administered latter 1 hour, each group equal lumbar injection 0.6% glacial acetic acid 10ml/kg of mice, the writhing response number of times of mice in time (incubation period) and 15 minutes that after observing injection, writhing response occurs in first time.Writhing response: abdominal part indent, the behavior reactions such as trunk is upheld with hind leg, hips up.Test data adopts SPSS software to add up.
Three. result
Table 1 extract Dichlorodiphenyl Acetate brings out the impact of mouse writhing reaction
Compare with matched group, * P < 0.05, * * P < 0.01
Result shows, compares with matched group, and in Radix Aconiti Lateralis Preparata reason, all there are reduction in various degree writhing number of times and the incubation period of liquid group and extract, have significant difference (P < 0.05, P < 0.01).In prompting Radix Aconiti Lateralis Preparata reason, liquid and extract all can reduce the mouse writhing reaction times that acetic acid causes, and delay writhing incubation period, and the mice stomachache that Dichlorodiphenyl Acetate brings out has analgesic activity.And under Isodose, extract action effect is better than liquid in Radix Aconiti Lateralis Preparata reason.
Embodiment 11: the extract impact on hardy effect
One. test material
1. laboratory animal
ICR mice, male and female half and half, Beijing Vital River Experimental Animals Technology Co., Ltd..
2. medicine and reagent
Liquid in Radix Aconiti Lateralis Preparata reason, extract (preparing according to embodiment 1 method) in Radix Aconiti Lateralis Preparata reason, Lerentang Pharmaceutical Factory, Zhongxin Pharmaceutical Group Co., Ltd., Tianj.
Bolus of ten powerful tonics, Beijing Tongrentang Technology Development Co.ltd. Pharmaceutical Factory.
3. instrument and equipment
Refrigerator, Siemens
Two. test method
Take ICR mice 60, male and female half and half, 6 groups are divided by body weight equilibrium, matched group, bolus of ten powerful tonics group (4 crude drug g/kg), liquid group (4 crude drug g/kg) in Radix Aconiti Lateralis Preparata reason, extract basic, normal, high dosage group (2,4,8 crude drug g/kg, prepare according to embodiment 1 method), once, continuous 7 days, matched group gave pure water to each administration group gastric infusion every day, administration volume is 20ml/kg, last is administered latter 1 hour, is placed in by mice in-5 DEG C of refrigerators, and mice was taken out after 2 hours by timing, add up each group of mouse survival number, calculate survival rate.Test data adopts SPSS software to add up.
Three. result
The impact on hardy effect of table 2 extract
Compare with matched group, * P < 0.05, * * P < 0.01
Result shows, compares with matched group, and in Radix Aconiti Lateralis Preparata reason, liquid group and extract group mouse survival rate all have significant difference, and in prompting Radix Aconiti Lateralis Preparata reason, liquid and extract all can improve mice percentage survival in cold, have the effect that righting is dispeled cold.Under Isodose, extract effect is better than liquid in Radix Aconiti Lateralis Preparata reason.
Claims (10)
1. the Chinese medicine composition of a warming middle-JIAO and strengthening the spleen, it is characterised in that its effective ingredient is made up of the raw material of following parts by weight: Radix Aconiti Lateralis Preparata (system) 100 parts, Radix Codonopsis 200 parts, the Rhizoma Atractylodis Macrocephalae (stir-fry) 150 parts, Rhizoma Zingiberis 100 parts, 100 parts of Radix Glycyrrhizae.
2. the Chinese medicine composition of a kind of warming middle-JIAO and strengthening the spleen according to claim 1, it is characterised in that described effective ingredient adopts following method to prepare: weigh each raw material by proportioning raw materials, standby；The whole flavour of a drug of prescription were with 6-12 times amount water extraction 4-10 hour and collected volatile oil, and it is 1.20-1.35 that extracting solution is concentrated under 50-60 DEG C of condition relative density, obtains concentrated solution A, obtains volatile oil B simultaneously；Concentrated solution A is dried, obtains dried object I；Volatile oil B and dried object I is merged, obtains dried object II；Dried object II, is effective ingredient.
3. the Chinese medicine composition of a kind of warming middle-JIAO and strengthening the spleen according to claim 2, it is characterized in that described effective ingredient adopts following method to prepare: the whole flavour of a drug of prescription were with 8-10 times amount water extraction 6-8 hour and collected volatile oil, it is 1.25-1.30 that extracting solution is concentrated under 50-60 DEG C of condition relative density, obtain concentrated solution A, obtain volatile oil B simultaneously；Concentrated solution A is dried, obtains dried object I；Volatile oil B and dried object I is merged, obtains dried object II；Dried object II, is effective ingredient.
4. the Chinese medicine composition of a kind of warming middle-JIAO and strengthening the spleen according to claim 3, it is characterized in that described effective ingredient adopts following method to prepare: the whole flavour of a drug of prescription were with 10 times amount water extraction 6 hours and collected volatile oil, it is 1.25 that extracting solution is concentrated under 50-60 DEG C of condition relative density, obtain concentrated solution A, obtain volatile oil B simultaneously；Concentrated solution A is dried, obtains dried object I；Volatile oil B and dried object I is merged, obtains dried object II；Dried object II, is effective ingredient.
5. the Chinese medicine composition of a kind of warming middle-JIAO and strengthening the spleen in any of the one of Claims 1-4, it is characterised in that: described Chinese medicine composition is possibly together with the acceptable adjuvant of pharmaceutics.
6. the Chinese medicine composition of a kind of warming middle-JIAO and strengthening the spleen according to claim 5, it is characterised in that: the acceptable adjuvant of described pharmaceutics is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and sodium sulfite.
7. the Chinese medicine composition of a kind of warming middle-JIAO and strengthening the spleen according to claim 6, it is characterised in that: the dosage form of described Chinese medicine composition is pill, tablet, capsule or oral liquid.
8. the preparation method of the Chinese medicine composition of a warming middle-JIAO and strengthening the spleen, it is characterised in that comprise the steps: to weigh Radix Aconiti Lateralis Preparata (system) 100 parts, Radix Codonopsis 200 parts, the Rhizoma Atractylodis Macrocephalae (stir-fry) 150 parts, Rhizoma Zingiberis 100 parts, 100 parts of Radix Glycyrrhizae；The whole flavour of a drug of prescription were with 6-12 times amount water extraction 4-10 hour and collected volatile oil, and it is 1.20-1.35 that extracting solution is concentrated under 50-60 DEG C of condition relative density, obtains concentrated solution A, obtains volatile oil B simultaneously；Concentrated solution A is dried, obtains dried object I；Volatile oil B and dried object I is merged, obtains dried object II；Dried object II, is effective ingredient.
9. the preparation method of the Chinese medicine composition of a kind of warming middle-JIAO and strengthening the spleen according to claim 8, it is characterized in that: the whole flavour of a drug of described prescription were with 8-10 times amount water extraction 6-8 hour and collected volatile oil, it is 1.25-1.30 that extracting solution is concentrated under 50-60 DEG C of condition relative density, obtain concentrated solution A, obtain volatile oil B simultaneously；Concentrated solution A is dried, obtains dried object I；Volatile oil B and dried object I is merged, obtains dried object II；Dried object II, is effective ingredient.
10. the preparation method of the Chinese medicine composition of a kind of warming middle-JIAO and strengthening the spleen according to claim 9, it is characterized in that: the whole flavour of a drug of described prescription were with 10 times amount water extraction 6 hours and collected volatile oil, it is 1.25 that extracting solution is concentrated under 50-60 DEG C of condition relative density, obtain concentrated solution A, obtain volatile oil B simultaneously；Concentrated solution A is dried, obtains dried object I；Volatile oil B and dried object I is merged, obtains dried object II；Dried object II, is effective ingredient.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109260452A (en) * | 2018-12-14 | 2019-01-25 | 新乡医学院第附属医院 | A kind of Chinese medicine composition for preventing gastrointestinal convulsion and preparation method thereof, oral solution and application |
| CN111743994A (en) * | 2020-07-31 | 2020-10-09 | 南京同仁堂药业有限责任公司 | Traditional Chinese medicine preparation for warming middle-jiao and invigorating spleen and preparation method thereof |
-
2014
- 2014-12-19 CN CN201410798186.XA patent/CN105749199A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 中华人民共和国卫生部药典委员会编: "《中华人民共和国卫生部药品标准中药成方制剂第二十册》", 31 December 1998 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109260452A (en) * | 2018-12-14 | 2019-01-25 | 新乡医学院第附属医院 | A kind of Chinese medicine composition for preventing gastrointestinal convulsion and preparation method thereof, oral solution and application |
| CN111743994A (en) * | 2020-07-31 | 2020-10-09 | 南京同仁堂药业有限责任公司 | Traditional Chinese medicine preparation for warming middle-jiao and invigorating spleen and preparation method thereof |
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