CN103271356B - Composition for enhancing immunity and relieving physical fatigue and preparation method of composition - Google Patents

Abstract

The invention discloses a composition for enhancing immunity and relieving physical fatigue and a preparation method of the composition. The composition comprises the ingredients as follows: 30-40 g of pseudo-ginseng, 10-15 g of cordyceps sinensis or cordyceps militaris, 2-3 g of lycopene, 10-15 g of lucid ganoderma, 10-15 g of morinda officinalis, 10-15 g of boxthorn fruits, 50-70 mg of organic selenium, 550-650 mg of vitamin A, 125-126 mg of vitamin B, 130-140 mg of vitamin C and 5-8 g of other accessories. According to the composition and the preparation method, used raw material extracts are turned into micro molecules which can be absorbed by human bodies after a nanometer cell wall-breaking technology is used, the comprehensive utilization rate of precious ingredients is increased greatly, a scientific basis is provided for industrialized and standardized production, the product quality is controllable, and the curative effect can be fully developed. The composition has the functions in aspects such as air supplying and refreshing, immunity enhancing, oxidation and aging resistance, physical fatigue relief, assistance in memory improving, kidney tonifying, and the like. The flavor of the composition is easy to accept, the color and luster are pure and natural, the appearance is attractive and generous, and the composition is applicable to all age groups.

Description

A kind of immunity, alleviating physical fatigue composition and method of making the same of strengthening

Technical field

The present invention relates to field of health care products, be specifically related to one enrich blood raw new, the row stasis of blood of promoting blood circulation, the immunity that strengthens, anti-oxidant, anti-ageing, alleviating physical fatigue, auxiliary improvement of memory health products (highly condensed nutritious food) composition and method of making the same.

Background technology

05 Yue19Ju Xinhua News Agency special despatch in 2012, develop in a healthy way as " Chinese health treatment industry development report " issue in Beijing on the 18th in 05 month in 2012 of aim taking guidance and the promotion China health treatment industry, this China of stem health treatment blue book is by the China health care leader of association, the State-owned Assets Supervision and Administration Commission of State Council research center tissue, lasts half a year and writes and form.Show according to the data of quoting the seminar of Chinese international inferior health academy's successes in blue book, account for 5% the people of Chinese true health, the shared total population ratio of sub-health state person is up to 77%, and the number of China in sub-health state surpassed 700,000,000.

According to the World Health Organization, to healthy definition, research both domestic and external shows, modern society meets health standards person and account for only 15% left and right of total crowd.What is interesting is, in crowd, be diagnosed as ill, what belong to unhealthy condition also accounts for 15% left and right, if healthy and disease are regarded as to the two ends of life process, it is just as a biapiculate olive so, middle protrude a bulk of, in health and ill transition state---inferior health between the two, in whole world population, 70% people is in sub-health state just.Through rough estimates, China accounts for 8% of total income in the cost per capita aspect healthy, and this ratio of western developed country is 6 times of left and right of China, and health products industry development potentiality are large.

We conventionally say and have suffered from disease, but " disease " is different from " disease " implication in ancient times." disease " refers to subtle minor illness (disease), if do not taken effective measures, will develop into visible degree, just be called " disease ".This state taking a disease, modern science, " inferior health " or " third state ", claims " not sick " in traditional Chinese medicine." sick " is not anosis, neither visible serious disease, and by traditional Chinese medical science viewpoint, opinion is that health has occurred that negative and positive, qi and blood, internal organs seek the non-equilibrium state of defending.Our ancestors recognize there has been disease except positive searching is except the method for disease for a long time, have also accumulated the measure of many prevention illness.Huangdi's Internal Classics has day: " sage's preventing diseases instead for the treatment of diseases; husband's disease become then medicine it, disorderly become then to control it, is example still thirsty and wear well; make weapons after the fight has began, also evening? " the ancestors that can find out brightly thus us have recognized that should " not rain silk fabric tassel, take preventive measures " to disease important.

Inferior health is a kind of critical condition, in the people of sub-health state, although there is no clear and definite disease, occurs the decline of spiritual vigor and adaptive capacity, if this state can not be corrected timely, is very easy to cause psychosomatic disease.Comprise: mental handicape, enterogastric diseases, hypertension, coronary heart disease, cancer, sexual function decline, burnout, absent minded, mood is irritated, insomnia, digestive function are bad, poor appetite, abdominal distension, nervous, uncomfortable in chest, constipation, suffer from diarrhoea, feel very tired out, even has the dead sensation of wish.But physical examination there is no the problem on organ, so be mainly functional problem.In the people of sub-health state, except tired and uncomfortable, can not be in peril of one's life.If but encounter highly and to stimulate, as under the stress situation such as stay up late, fly into a rage, be easy to occur sudden death, be exactly " overworking death "." overworking death "---be a kind of comprehensive disease, refer in the labout process under non-physiological state, people's normal working law and rule of life are destroyed, tired alluvial to overwork state transitions in body, make blood pressure rising, artery sclerosis aggravation, and then occur fatal state.

The reason that causes inferior health is diversified, but the overtired first cause that is still.Along with social development, the progress of science and technology, the quickening of rhythm of life, the requirement abundant, cultural life of material life is more and more higher, inferior health from before, old artificial main body, develop into the generality state that comprises now all orders of society, all ages.Break away from the puzzlement of inferior health, people should ensure rational meals and balanced nutrition, carry out moderate exercise, remove bad habit (smoking cessation limit wine), keep happy.

Pseudo-ginseng has another name called pseudo-ginseng, is described as " invaluable "." jade is seized medicine solution " recorded: " with battalion hemostasis, the row stasis of blood of promoting blood circulation, row hemostasis and the new blood of sword." supplementary Amplifications of the Compendium of Materia Medica records: " and ginseng qi-tonifying the first, pseudo-ginseng enriches blood the first, taste with and merit also etc., therefore claim Panax pseudoginseng, be the most precious person of Chinese medicine." active ingredient of pseudo-ginseng hydrolysate is notoginsenoside, is topmost active component in pseudo-ginseng, has enhanced machine body immunity function, has stronger antitumor activity, anti-liver injury, anti-inflammatory properties; There is promoting blood circulation to remove blood stasis, platelet aggregation-against, antithrombotic forms effect; There is bidirectional modulation blood sugar, reduce blood fat, cholesterol, inhibition artery sclerosis function; Have hemangiectasis, reduce blood pressure, improve microcirculation, increase CBF, prevention and treatment heart and brain tissues ischemic, air hunger, promote blood cell metabolism, balance adjustment blood cell, and bidirectional modulation nervous centralis, improves mentally, strengthens learning and memory ability; Have the protein, ribonucleic acid (RNA), DNA (DNA) of promotion synthetic, improve the health delay senility, the effect such as analgesia.

River in Zhejiang Province Chinese caterpillar fungus or Cordyceps sinensis are described as " east mountain balsam " and " kidney tonifying holy product ", are a kind of traditional high-grade nourishing rare traditional Chinese medicines, have the multiple efficacies such as the function of immune system of adjusting, antitumor, antifatigue." Xinhua's book on Chinese herbal medicine outline " records the effect of " taste is sweet, and property is flat, has liver and kidney benefiting, mends marrow, hemostasis and phlegm "." " the arteries and veins medicine connection pearl property of medicine is examined " record: " secret lean gas, specially mends the gate of vitality." " Chinese medicinal fungi " introduction: often edible Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus can promote digestion, regulate immunologic function, strengthen the resistance of human body to various diseases.In the U.S., classify Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus as anti-cancer agent, enter clinical three phases.Modern study shows, Chinese caterpillar fungus mainly contains cordycepic acid, cordycepin, amino acid, sterol, sweet mellow wine, alkaloid, vitamin B1, B2, polysaccharide and mineral matter etc., has the immunity of organisms of raising, regulates immunity, delays senility, improves learning and memory, antitumaous effect; Cardiovascular system there is is step-down, reduces MCO, improve myocardial ischemia, antiarrhythmic effect; Other position to health has Conclusion Decreasing controlling nocturnal emission with astringent drugs, the effect such as beneficial cloudy tonifying lung, antibacterial, tranquilizing soporific, nourishing.

Lycopene is described as " plant gold ", it is one of found powerful antioxidant in natural plant at present, can cell growth metabolism play regulating and controlling effect, strengthen human immune system's prevention and suppress tumour, angiocardiopathy preventing and plurality of health care functions effect, can effectively preventing because of aging, the various diseases that immunity degradation causes.2003, U.S.'s Time was listed in lycopene first of " human health is contributed to maximum food ", is called " plant gold " by western countries.Lycopene especially has remarkable result to preventing and treating prostate cancer, lung cancer, breast cancer, the cancer of the uterus etc., the effectively diffusion of inhibition cancer cell and copying, can impel growth and the regeneration of cell, beauty treatment Eradicates wrinkle, maintain skin health, delay senility, improve the effects such as ability of learning and memory, it receives countries in the world expert's concern, is now widely accepted in American-European, Japan and Chinese Hong Kong & Taiwan areas.

Glossy ganoderma is described as " celestial grass ".Shennong's Herbal is classified glossy ganoderma as top grade, call purple sesame " god benefit essence is protected in main deafness, sharp joint, hard muscles and bones, good color, clothes are made light of one's life by commiting suicide and are not always prolonged life for a long time." " bowl spares increases wisdom not to be forgotten for main knot in the heart, the beneficial motive, and food of a specified duration is made light of one's life by commiting suicide not old, prolongs life and becomes an immortal to call red sesame.Modern study shows; glossy ganoderma has antitumor action, is that best immunologic function regulates and activator, has the hepatic injury that multiple physics and chemistry and biological factor are caused and has protection detoxication; myocardial ischemia is had to protective effect, can be widely used in treatment and the prevention of coronary heart diseases and angina pectoris etc.To high fat of blood patient, glossy ganoderma can obviously reduce cholesterolemia, lipoprotein and triglyceride, and the formation of energy prevention of arterial AP.Contained polysaccharide, the polypeptide etc. of glossy ganoderma has obvious function of delaying senility.Glossy ganoderma is just for nervous breakdown and insomnia, therefore it plays good effect to maincenter.In NF, glossy ganoderma is exactly the medicine of effectively sleeping peacefully and allaying excitement.

Morinda officinalis is one of four famous great Nan medicines of China, and in antidotal medicine, Morinda officinalis is one of the most frequently used Chinese medicine, and the place of production common people have the food custom of " with the same pot of meat " for a long time, are described as " key medicine of tonifying kidney and strengthening yang "." book on Chinese herbal medicine converge " recorded: " be the medicine of kidney channel blood system, top capping help Yuanyang stomach Qi grow, oneself moves back all void, its merit can Ju Bi Collettii, on the stem of noble dendrobium.Its property is heat how, reinforcing yin essence of same golden cypress, the wind-weed, same to desert cistanche, cynomorium songaricum are supporing yang, expensive use people avoid hot weather while using drugs of hot nature, avoiding cold wearher while using drugs of cold nature ear." Morinda officinalis have anti-ageing, strengthen immunity, regulate endocrine, improve learning memory and decline, promote the effects such as hematopoiesis, antidepression, antitumor, anti-inflammatory, chill rheumatism, attenuation and analgesia.Especially the diseases such as cold infertile, the irregular menstruation of impotence due to deficiency of the kidney, seminal emission premature ejaculation, few abdomen crymodynia, urinary incontinence, palace, wind-cold-dampness arthralgia, soreness and weakness of waist and knees, rheumatism limb gas, muscles and bones impotence is soft are had to significant curative effect.

Matrimony vine is described as " medication tonic good merchantable brand " from ancient times.Compendium of Material Medica is recorded: " spring is adopted folium lycii, name day essence grass; Summer picks flowers, name houseleek; Qiu Caizi, the name fruit of Chinese wolfberry; Dong Caigen, the name root bark of Chinese wolf-berry." " dietetic materia medica " record: " hard muscle is resistance to old, except wind, help muscles and bones, can benefit enter, and removes consumptive disease." modern study shows, matrimony vine contains abundant carrotene, contains a large amount of retinol1s, B1, B2, C and calcium, iron etc., is the essential nutriment of healthy eye, is commonly called as " bright eye ".Antioxidant in matrimony vine, effectively prevention of cardiac and cancer of beta carotene, protection skin is avoided sun damage, has the blood sugar of reduction, hypotensive, lipotropy, and can antiatherosclerosis.

At present, the health products on market with simple function are existing multiple, as Radix Notoginseng powder, lucidum spore powder, lycopene sheet, Cordyceps sinensis or river in Zhejiang Province Cordyceps sinensis tablet etc., but market does not have corresponding compound product, effect of pseudo-ginseng, glossy ganoderma, lycopene sheet, Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus is not brought into play, cause precious food materials to be wasted, make consumer not obtain ideal product, form rational meals and balanced nutrition.

Summary of the invention

A kind of enhancing immunity, fatigue-relieving composition are the object of this invention is to provide, said composition relates to the necessary nutrient minerals and vitamins of human body, having the functions such as raw new, the row stasis of blood of promoting blood circulation of enriching blood, the immunity that strengthens, anti-oxidant, anti-ageing, alleviating physical fatigue, auxiliary improvement of memory, kidney tonifying.

To achieve these goals, technical scheme of the present invention is: a kind of immunity, fatigue-relieving composition of strengthening is provided, comprise following each component and content: 30～40 grams of pseudo-ginseng, Cordyceps sinensis or 10～15 grams of river in Zhejiang Province Chinese caterpillar funguses, 2～3 grams of lycopenes, 10～15 grams of glossy ganodermas, 10～15 grams of Morinda officinalis, 10～15 grams of the fruits of Chinese wolfberry, Organic Selenium 50～70 micrograms, vitamin A 550～650 micrograms, cobalamin 5～6 micrograms, 130～140 milligrams of vitamin Cs, 7～8 grams of all the other auxiliary materials.

Described auxiliary material comprises starch or soy meal and sweetener.

Another object of the present invention is to provide a kind of preparation method who strengthens immunity, fatigue-relieving composition, comprise the following steps:

(1) preparation of Notogineng Extract

A, get clean pseudo-ginseng, be cut into sheet, put in drying box 50～60 DEG C, establish constant temperature, dry 7～8 hours, pulverize, cross 20 mesh sieves; Again pulverize, cross 60 mesh sieves; Hydrolysis is extracted 2～3 times, merges extract; Use Rotary Evaporators is concentrated, obtains pseudo-ginseng extract powder;

B, pseudo-ginseng extract powder is placed on the shelf in the drying box of freeze drier, paving amount thickness is 1～2cm, opens refrigeration plant and vavuum pump, and the case internal pressure that keeps dry is 10～12Pa; By the cryovial in shelf, the temperature in drying box is adjusted to-39～-37 DEG C, freezing 2～3 hours;

C, drying box internal pressure is down to 1.0～1.2Pa, opens heating system, first shelf temperature is slowly heated to 7～8 DEG C from-39～-37 DEG C, this temperature-rise period is 8～10 hours; Slowly shelf temperature is adjusted to 25～28 DEG C more again, this temperature-rise period is 7～9 hours, obtains Radix Notoginseng powder dried frozen aquatic products after outlet, and Radix Notoginseng powder dried frozen aquatic products is made to 50～200 object fine powders in low temperature powder beater, obtains Notogineng Extract, for subsequent use;

(2) preparation of Cordyceps sinensis or river in Zhejiang Province Cordyceps, lycopene extract

A, get clean Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus, lycopene and put respectively in drying box 60 DEG C, freeze-day with constant temperature 4～5 hours, pulverizes, and crosses 60 mesh sieves; Hydrolysis extraction 2～3 times, merges clean Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus hydrolyzed extract and merges lycopene hydrolysis extract, uses Rotary Evaporators concentrated, obtains respectively Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus extract powder and lycopene extract powder;

B, Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus extract powder, lycopene extract powder are placed in respectively on the shelf in the drying box of freeze drier, paving amount thickness is 1～2cm, opens refrigeration plant and vavuum pump, and the case internal pressure that keeps dry is 10～12Pa; By the cryovial in shelf, the temperature in drying box is adjusted to-39～-37 DEG C, freezing 2～3 hours;

C, by drying box Pressure Drop to 1.0～1.2Pa, open heating system, first shelf temperature is slowly heated to 7～8 DEG C from-39～-37 DEG C, this temperature-rise period is 8～10 hours; Slowly shelf temperature is adjusted to 25～28 DEG C more again, this temperature-rise period is 7～9 hours, obtains respectively Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus powder dried frozen aquatic products, lycopene powder dried frozen aquatic products after outlet; Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus powder dried frozen aquatic products and lycopene powder dried frozen aquatic products are made to 50～200 object fine powders in low temperature powder beater, respectively Cordyceps sinensis or river in Zhejiang Province Cordyceps and lycopene extract, for subsequent use;

(3) preparation of Ganodenna Lucidum P.E

A, get clean glossy ganoderma and put in drying box 60 DEG C, freeze-day with constant temperature 8 hours, pulverizes, and crosses 20 mesh sieves; Again pulverize, cross 60 mesh sieves; Hydrolysis is extracted 2～3 times, merges extract, uses Rotary Evaporators concentrated, obtains glossy ganoderma extract powder;

B, glossy ganoderma extract powder is placed on the shelf in the drying box of freeze drier, paving amount thickness is 1cm, opens refrigeration plant and vavuum pump, and the case internal pressure that keeps dry is 10～12Pa; By the cryovial in shelf, the temperature in drying box is adjusted to-39～-37 DEG C, freezing 2～3 hours;

C, drying box internal pressure is down to 1.0～1.2Pa, opens heating system, first shelf temperature is slowly heated to 7～8 DEG C from-39～-37 DEG C, this temperature-rise period is 8～10 hours; Slowly shelf temperature is adjusted to 25～28 DEG C more again, this temperature-rise period is 7～9 hours, obtains glossy ganoderma powder dried frozen aquatic products after outlet, and glossy ganoderma powder dried frozen aquatic products low temperature powder beater is made to 50～200 object fine powders, obtains Ganodenna Lucidum P.E, for subsequent use;

(5) preparation of Morinda officinalis extract powder and Fructus Lycii extractum powder

Get put respectively in drying box 60 DEG C of clean Morinda officinalis, the fruit of Chinese wolfberry, freeze-day with constant temperature 8 hours, pulverizes, and crosses 20 mesh sieves; Again pulverize, cross 60 mesh sieves; Hydrolysis is extracted 2～3 times, and merging Morinda officinalis How and merging medlar extract liquid, use Rotary Evaporators concentrated, obtains respectively Morinda officinalis extract powder and Fructus Lycii extractum powder, for subsequent use;

(6) goods after total to Notogineng Extract, Cordyceps sinensis or river in Zhejiang Province Cordyceps, lycopene extract, Ganodenna Lucidum P.E, Morinda officinalis extract powder, Fructus Lycii extractum powder, Organic Selenium, vitamin A, cobalamin, vitamin C and all the other auxiliary materials mixing are carried out to compressing tablet on Highspeedrotarytabletpress; (the present invention makes capsule, oral liquid, pill employing conventional means, does not state in detail at this)

(7) after compressing tablet, use chalk dust removal machine to go out powder on sheet, obtain qualified matrix band;

(8) obtaining after qualified matrix band, first carry out inner packing, tablet is carried out to aluminium-plastic bubble plate packing, carry out again external packing, the product aluminium-plastic panel pack sealing of the inner packing of learning from else's experience, mounted box, vanning, tape seal, packing, by quality testing department sampling inspection, warehouse-in after the assay was approved, deposits at dry, shady and cool place.

Said composition can be made tablet, capsule, oral liquid, pill.

The present invention uses after nanometer wall breaking technology raw materials, become the little molecule that human body can be absorbed, greatly improve the comprehensive utilization ratio of precious food materials, for industrialization, standardized production provide scientific basis, make product quality controlled, can give full play to curative effect, this product is developed for sub-health population exactly, functional, use crowd scope covers extensively, has filled up the domestic and international blank of this type of Realization of Product standardized production, has good market prospects.The necessary nutrient minerals and vitamins of human body involved in the present invention, has invigorating qi and refreshing, strengthens the function of the aspects such as immunity, anti-oxidant, anti-ageing, alleviating physical fatigue, auxiliary improvement of memory, kidney tonifying.The present composition uses crowd's scope to cover extensively, functional, and taste is easy to accept, and color and luster is honest natural, elegant in appearance, goes for all ages.By nanometer wall breaking technology preparation technology of the present invention, each raw material extract is beneficial to absorption of human body, has improved human absorptivity.

Detailed description of the invention

Embodiment 1

In every 100 grams of present compositions, contain 40 grams of pseudo-ginseng, 10 grams of Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar funguses, 2 grams of lycopenes, 10 grams of glossy ganodermas, 15 grams of Morinda officinalis, 15 grams of the fruits of Chinese wolfberry, Organic Selenium 60 micrograms, vitamin A 600 micrograms, cobalamin 6 micrograms, 140 milligrams of vitamin Cs, 6～7 grams of auxiliary materials such as starch or soy meal, sweetener (because of 1 gram of shared shortage in weight in every 100 grams of the nutrient prime replenisher such as Organic Selenium, vitamin, the other parts that its less than is 1 gram are supplied with auxiliary material).

Preparation process:

1, get clean out pseudo-ginseng put in drying box 60 DEG C of freeze-day with constant temperature 8 hours, pulverize, cross 20 mesh sieves; Again pulverize, cross 60 mesh sieves; Hydrolysis is extracted 2 times, merges extract, uses Rotary Evaporators concentrated, obtains pseudo-ginseng extract powder.Then, pseudo-ginseng extract powder is placed on the shelf in the drying box of freeze drier, paving amount thickness is 1cm, open refrigeration plant and vavuum pump, the case internal pressure that keeps dry is 10Pa, by the cryovial in shelf, the temperature in drying box is adjusted to-39～-37 DEG C, freezing 2 hours; Again by the Pressure Drop in drying box to 1.0Pa; Open heating system, first shelf temperature is slowly heated to 7～8 DEG C, about 8～10 hours of this temperature-rise period from-39～-37 DEG C; Slowly shelf temperature is adjusted to 25～28 DEG C more again, about 7～9 hours of this process, obtains Radix Notoginseng powder dried frozen aquatic products after outlet, dried frozen aquatic products low temperature powder beater is made to 50～200 object fine powders, obtains Notogineng Extract, for subsequent use.

2, get clean out glossy ganoderma put in drying box 60 DEG C of freeze-day with constant temperature 8 hours, pulverize, cross 20 mesh sieves; Again pulverize, cross 60 mesh sieves; Hydrolysis is extracted 2～3 times, merges extract, uses Rotary Evaporators concentrated, obtains extract powder.Then, glossy ganoderma extract powder is placed on the shelf in the drying box of freeze drier, paving amount thickness is 1cm, opens refrigeration plant and vavuum pump, and the case internal pressure that keeps dry is 10～12Pa; By the cryovial in shelf, the temperature in drying box is adjusted to-39～-37 DEG C, freezing 2～3 hours, then by Pressure Drop to 1.0～1.2Pa; Open heating system, first shelf temperature is slowly heated to 7～8 DEG C, about 8～10 hours of this process from-39～-37 DEG C; Slowly shelf temperature is adjusted to 25～28 DEG C again, about 7～9 hours of this process, obtains glossy ganoderma powder dried frozen aquatic products after outlet, dried frozen aquatic products low temperature powder beater is made to 50～200 object fine powders, obtains Ganodenna Lucidum P.E, for subsequent use.

3, get the lycopene finished product that originates from Xinjiang of cleaning out Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus and meeting raw material requirement and put respectively in drying box 60 DEG C, freeze-day with constant temperature 4 hours, pulverizes, and crosses 60 mesh sieves; Be hydrolyzed and extract 2～3 times, merge respectively extract separately, use Rotary Evaporators concentrated, obtain respectively Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus extract powder and lycopene extract powder.Then, Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus extract powder, lycopene extract powder are placed in respectively on the shelf in the drying box of freeze drier, paving amount thickness is 1cm, opens refrigeration plant and vavuum pump, and the case internal pressure that keeps dry is 10～12Pa; By the cryovial in shelf, the temperature in drying box is adjusted to-39～-37 DEG C, freezing 2～3 hours; Again by the Pressure Drop to 1.0 in drying box～1.2Pa; Open heating system, first shelf temperature is slowly heated to 7～8 DEG C, about 8～10 hours of this process from-39～-37 DEG C; Slowly shelf temperature is adjusted to 25～28 DEG C again, about 7～9 hours of this process, after outlet, obtain respectively Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus powder dried frozen aquatic products and lycopene powder dried frozen aquatic products, dried frozen aquatic products low temperature powder beater is made to 50～200 object fine powders, obtain Cordyceps sinensis or river in Zhejiang Province Cordyceps, lycopene extract, for subsequent use.

4, get put in drying box 60 DEG C of cleaning out Morinda officinalis, the fruit of Chinese wolfberry, freeze-day with constant temperature 8 hours, pulverizes, and crosses 20 mesh sieves; Again pulverize, cross 60 mesh sieves; Hydrolysis is extracted 2～3 times, merges extract, uses Rotary Evaporators concentrated, obtains Morinda officinalis extract powder and Fructus Lycii extractum powder, for subsequent use.

5, carry out compatibility according to the proportion compatibility in instantiation 1 of the present invention, Notogineng Extract, Cordyceps sinensis or river in Zhejiang Province Cordyceps, lycopene extract, Ganodenna Lucidum P.E, Morinda officinalis extract powder, Fructus Lycii extractum powder, organic selenium powder, vitamin A powder, cobalamin powder, vitamin c powder and all the other auxiliary materials is evenly total mixed; Total mixed step is according to common process;

6, the goods after always mixing are carried out to compressing tablet on Highspeedrotarytabletpress;

7, after compressing tablet, use chalk dust removal machine to go out powder on sheet, matrix band;

8, obtaining after qualified matrix band, first carry out inner packing, tablet is carried out to aluminium-plastic bubble plate packing, carry out again external packing, the product aluminium-plastic panel pack sealing of the inner packing of learning from else's experience, mounted box, vanning, tape seal, packing, by quality testing department sampling inspection, warehouse-in after the assay was approved, deposits at dry, shady and cool place.

9, can obtain the product produced according to the proportion compatibility in instantiation 1 of the present invention.

Embodiment 2

In every 100 grams of said compositions, contain 30 grams of pseudo-ginseng, 15 grams of Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar funguses, 2 grams of lycopenes, 15 grams of glossy ganodermas, 15 grams of Morinda officinalis, 15 grams of the fruits of Chinese wolfberry, Organic Selenium 60 micrograms, vitamin A 600 micrograms, cobalamin 6 micrograms, 140 milligrams of vitamin Cs, approximately 6～7 grams of auxiliary materials such as starch or soy meal, sweetener (because of 1 gram of shared shortage in weight in every 100 grams of the nutrient prime replenisher such as Organic Selenium, vitamin, the other parts that its less than is 1 gram are supplied with auxiliary material).

1, get clean out pseudo-ginseng put in drying box 60 DEG C of freeze-day with constant temperature 8 hours, pulverize, cross 20 mesh sieves; Again pulverize, cross 60 mesh sieves; Hydrolysis is extracted 2 times, merges extract, uses Rotary Evaporators concentrated, obtains pseudo-ginseng extract powder.Then, pseudo-ginseng extract powder is placed on the shelf in the drying box of freeze drier, paving amount thickness is 1cm, open refrigeration plant and vavuum pump, the case internal pressure that keeps dry is 10Pa, by the cryovial in shelf, the temperature in drying box is adjusted to-39～-37 DEG C, freezing 2 hours; Again by the Pressure Drop in drying box to 1.0Pa; Open heating system, first shelf temperature is slowly heated to 7～8 DEG C, about 8～10 hours of this temperature-rise period from-39～-37 DEG C; Slowly shelf temperature is adjusted to 25～28 DEG C more again, about 7～9 hours of this process, obtains Radix Notoginseng powder dried frozen aquatic products after outlet, dried frozen aquatic products low temperature powder beater is made to 50～200 object fine powders, obtains Notogineng Extract, for subsequent use.

2, get clean out glossy ganoderma put in drying box 60 DEG C of freeze-day with constant temperature 8 hours, pulverize, cross 20 mesh sieves; Again pulverize, cross 60 mesh sieves; Hydrolysis is extracted 2～3 times, merges extract, uses Rotary Evaporators concentrated, obtains extract powder.Then, glossy ganoderma extract powder is placed on the shelf in the drying box of freeze drier, paving amount thickness is 1cm, opens refrigeration plant and vavuum pump, and the case internal pressure that keeps dry is 10～12Pa; By the cryovial in shelf, the temperature in drying box is adjusted to-39～-37 DEG C, freezing 2～3 hours, then by Pressure Drop to 1.0～1.2Pa; Open heating system, first shelf temperature is slowly heated to 7～8 DEG C, about 8～10 hours of this process from-39～-37 DEG C; Slowly shelf temperature is adjusted to 25～28 DEG C again, about 7～9 hours of this process, obtains glossy ganoderma powder dried frozen aquatic products after outlet, dried frozen aquatic products low temperature powder beater is made to 50～200 object fine powders, obtains Ganodenna Lucidum P.E, for subsequent use.

3, get the lycopene finished product that originates from Xinjiang of cleaning out Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus and meeting raw material requirement and put respectively in drying box 60 DEG C, freeze-day with constant temperature 4 hours, pulverizes, and crosses 60 mesh sieves; Be hydrolyzed and extract 2～3 times, merge respectively extract separately, use Rotary Evaporators concentrated, obtain respectively Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus extract powder and lycopene extract powder.Then, Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus extract powder, lycopene extract powder are placed in respectively on the shelf in the drying box of freeze drier, paving amount thickness is 1cm, opens refrigeration plant and vavuum pump, and the case internal pressure that keeps dry is 10～12Pa; By the cryovial in shelf, the temperature in drying box is adjusted to-39～-37 DEG C, freezing 2～3 hours; Again by the Pressure Drop to 1.0 in drying box～1.2Pa; Open heating system, first shelf temperature is slowly heated to 7～8 DEG C, about 8～10 hours of this process from-39～-37 DEG C; Slowly shelf temperature is adjusted to 25～28 DEG C again, about 7～9 hours of this process, after outlet, obtain respectively Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus powder dried frozen aquatic products and lycopene powder dried frozen aquatic products, dried frozen aquatic products low temperature powder beater is made to 50～200 object fine powders, obtain Cordyceps sinensis or river in Zhejiang Province Cordyceps, lycopene extract, for subsequent use.

4, get put in drying box 60 DEG C of cleaning out Morinda officinalis, the fruit of Chinese wolfberry, freeze-day with constant temperature 8 hours, pulverizes, and crosses 20 mesh sieves; Again pulverize, cross 60 mesh sieves; Hydrolysis is extracted 2～3 times, merges extract, uses Rotary Evaporators concentrated, obtains Morinda officinalis extract powder and Fructus Lycii extractum powder, for subsequent use.

5, carry out compatibility according to the proportion compatibility in instantiation 2 of the present invention, Notogineng Extract, Cordyceps sinensis or river in Zhejiang Province Cordyceps, lycopene extract, Ganodenna Lucidum P.E, Morinda officinalis extract powder, Fructus Lycii extractum powder, organic selenium powder, vitamin A powder, cobalamin powder, vitamin c powder and all the other auxiliary materials is evenly total mixed; Total mixed step is according to common process;

6, the goods after always mixing are carried out to compressing tablet on Highspeedrotarytabletpress;

7, after compressing tablet, use chalk dust removal machine to go out powder on sheet, matrix band;

8, obtaining after qualified matrix band, first carry out inner packing, tablet is carried out to aluminium-plastic bubble plate packing, carry out again external packing, the product aluminium-plastic panel pack sealing of the inner packing of learning from else's experience, mounted box, vanning, tape seal, packing, by quality testing department sampling inspection, warehouse-in after the assay was approved, deposits at dry, shady and cool place.

9, can obtain the product produced according to the proportion compatibility in instantiation 2 of the present invention.

Embodiment 3

In every 100 grams of said compositions, contain 35 grams of pseudo-ginseng, 15 grams of Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar funguses, 3 grams of lycopenes, 14 grams of glossy ganodermas, 13 grams of Morinda officinalis, 15 grams of the fruits of Chinese wolfberry, Organic Selenium 55 micrograms, vitamin A 600 micrograms, cobalamin 6 micrograms, 130 milligrams of vitamin Cs, approximately 5～6 grams of auxiliary materials such as starch or soy meal, sweetener (because of 1 gram of shared shortage in weight in every 100 grams of the nutrient prime replenisher such as Organic Selenium, vitamin, the other parts that its less than is 1 gram are supplied with auxiliary material).

1, get clean out pseudo-ginseng put in drying box 60 DEG C of freeze-day with constant temperature 8 hours, pulverize, cross 20 mesh sieves; Again pulverize, cross 60 mesh sieves; Hydrolysis is extracted 3 times, merges extract, uses Rotary Evaporators concentrated, obtains pseudo-ginseng extract powder.Then, pseudo-ginseng extract powder is placed on the shelf in the drying box of freeze drier, paving amount thickness is 1cm, open refrigeration plant and vavuum pump, the case internal pressure that keeps dry is 10Pa, by the cryovial in shelf, the temperature in drying box is adjusted to-39 DEG C, freezing 2 hours; Again by the Pressure Drop in drying box to 1.0Pa; Open heating system, first shelf temperature is slowly heated to 7 DEG C, about 8 hours of this temperature-rise period from-39 DEG C; Slowly shelf temperature is adjusted to 25 DEG C more again, about 7 hours of this process, obtains Radix Notoginseng powder dried frozen aquatic products after outlet, dried frozen aquatic products low temperature powder beater is made to 200 object fine powders, obtains Notogineng Extract, for subsequent use.

2, get clean out glossy ganoderma put in drying box 60 DEG C of freeze-day with constant temperature 8 hours, pulverize, cross 20 mesh sieves; Again pulverize, cross 60 mesh sieves; Hydrolysis is extracted 3 times, merges extract, uses Rotary Evaporators concentrated, obtains extract powder.Then, glossy ganoderma extract powder is placed on the shelf in the drying box of freeze drier, paving amount thickness is 1cm, opens refrigeration plant and vavuum pump, and the case internal pressure that keeps dry is 12Pa; By the cryovial in shelf, the temperature in drying box is adjusted to-37 DEG C, freezing 3 hours, then by Pressure Drop to 1.2Pa; Open heating system, first shelf temperature is slowly heated to 8 DEG C, about 10 hours of this process from-37 DEG C; Slowly shelf temperature is adjusted to 28 DEG C again, about 9 hours of this process, obtains glossy ganoderma powder dried frozen aquatic products after outlet, dried frozen aquatic products low temperature powder beater is made to 100 object fine powders, obtains Ganodenna Lucidum P.E, for subsequent use.

3, get the lycopene finished product that originates from Xinjiang of cleaning out Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus and meeting raw material requirement and put respectively in drying box 60 DEG C, freeze-day with constant temperature 4 hours, pulverizes, and crosses 60 mesh sieves; Be hydrolyzed and extract 2～3 times, merge respectively extract separately, use Rotary Evaporators concentrated, obtain respectively Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus extract powder and lycopene extract powder.Then, Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus extract powder, lycopene extract powder are placed in respectively on the shelf in the drying box of freeze drier, paving amount thickness is 1cm, opens refrigeration plant and vavuum pump, and the case internal pressure that keeps dry is 11Pa; By the cryovial in shelf, the temperature in drying box is adjusted to-39 DEG C, freezing 3 hours; Again by the Pressure Drop in drying box to 1.0Pa; Open heating system, first shelf temperature is slowly heated to 8 DEG C, about 10 hours of this process from-39 DEG C; Slowly shelf temperature is adjusted to 25 DEG C again, about 7 hours of this process, obtains respectively Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus powder dried frozen aquatic products and lycopene powder dried frozen aquatic products after outlet, dried frozen aquatic products low temperature powder beater is made to 150 object fine powders, obtain Cordyceps sinensis or river in Zhejiang Province Cordyceps, lycopene extract, for subsequent use.

4, get put in drying box 60 DEG C of cleaning out Morinda officinalis, the fruit of Chinese wolfberry, freeze-day with constant temperature 8 hours, pulverizes, and crosses 20 mesh sieves; Again pulverize, cross 60 mesh sieves; Hydrolysis is extracted 2～3 times, merges extract, uses Rotary Evaporators concentrated, obtains Morinda officinalis extract powder and Fructus Lycii extractum powder, for subsequent use.

5, carry out compatibility according to the proportion compatibility in instantiation 3 of the present invention, Notogineng Extract, Cordyceps sinensis or river in Zhejiang Province Cordyceps, lycopene extract, Ganodenna Lucidum P.E, Morinda officinalis extract powder, Fructus Lycii extractum powder, organic selenium powder, vitamin A powder, cobalamin powder, vitamin c powder and all the other auxiliary materials is evenly total mixed; Total mixed step is according to common process;

6, the goods after always mixing are carried out to compressing tablet on Highspeedrotarytabletpress;

7, after compressing tablet, use chalk dust removal machine to go out powder on sheet, matrix band;

8, obtaining after qualified matrix band, first carry out inner packing, tablet is carried out to aluminium-plastic bubble plate packing, carry out again external packing, the product aluminium-plastic panel pack sealing of the inner packing of learning from else's experience, mounted box, vanning, tape seal, packing, by quality testing department sampling inspection, warehouse-in after the assay was approved, deposits at dry, shady and cool place.

9, can obtain the product produced according to the proportion compatibility in instantiation 3 of the present invention.

Health products of the present invention (highly condensed nutritious food) composition, in this product formula range, below formula is per day for adults consumption, comprise following supplementary material: 1～9 gram of pseudo-ginseng, 1～9 gram of Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus, 7～20 milligrams of lycopenes, 2～12 grams of glossy ganodermas, 2～10 grams of Morinda officinalis, 2～12 grams of the fruits of Chinese wolfberry, Organic Selenium 15～70 micrograms, dehydroretinol 50～500 micrograms, cobalamin 1～5 microgram, 30～400 milligrams of vitamin Cs, 2～8 grams of the auxiliary materials such as starch or soy meal, sweetener.Can debug according to different proportion according to different demands.In the time of large-scale production can according to kilogram or ton be unit, small-scale production can be in grams, weight can increase or reduce.Follow preparation method of the present invention, can obtain this formulation product.

Strengthen immunity experiment: the present invention confirms to have the effect that strengthens immunity, experimental result and conclusion through animal experiment:

1, the impact of the present invention on DNFB inducing mouse DTH

The present invention that per os gives mouse various dose strengthened immunity, fatigue-relieving composition (tablet) after 1 month, auricular concha increases weight through homogeneity test of variance, meet homogeneity of variance requirement, carry out statistical disposition with the comparative approach between two of mean between multiple experimental group in one-way analysis of variance method and a control group, as shown in table 1:

The impact of table 1 present composition on DNFB inducing mouse DTH ( )

From table 1 result, the weightening finish of 150mg/kgbw group auricular concha is significantly higher than 0mg/kgbw group.

2, the present invention strengthens immunity, the impact of fatigue-relieving composition on NK cells in mice activity

Per os gives the present composition tablet 1 month of mouse various dose, through sin-1P1/2, (P is NK cytoactive to NK cytoactive, decimally represent) transform after carry out normal distribution, homogeneity test of variance, meet normal distribution requirement, carry out statistical disposition with the comparative approach between two of multiple experimental group in one-way analysis of variance method and a control group mean, as shown in table 2:

The impact of table 2 present composition on NK cells in mice activity ( )

From table 2 result, 50mg/kgbw, 150mg/kgbw group NK cytoactive is significantly higher than 0mg/kgbw group.

3, conclusion

1. cellular immune function: in the experiment of DNFB inducing mouse DTH, the weightening finish of 150mg/kgbw group auricular concha is significantly higher than 0mg/kgbw group.

2. NK cytoactive: in NK cells in mice determination of activity experiment, 50mg/kgbw, 150mg/kgbw group NK cytoactive is significantly higher than 0mg/kgbw group.

The experiment of small white mouse antifatigue:

Show through zoopery, enhancing immunity of the present invention, fatigue-relieving composition have significant anti-fatigue effect.

1, experimental animal

75 healthy and strong male white mouses, body weight 25 ± 2g.Experimental session all animals cleans level mouse pellet and aqua sterilisa freely eats.

2, test method

2.1 dosage and grouping

Swimming test and every biochemical indicator (full blood lactic, hepatic glycogen, serum urea nitrogen) animal used is all respectively divided into 5 groups by body weight small white mouse, i.e. negative (distilled water) control group (NCG), positive (Anshen Bunao mixture) control group (CCG), the low amount group of Millettia speciosa Champ.extract (LD), middle amount group (MD), a large amount group (HD), 15 every group.According to small white mouse body weight, present composition 100mg/kg is low amount group, and 200mg/kg is middle amount group, and 600mg/kg is a large amount group.The continuous gavage 30d of mouse, experimental group gives the each group of present composition, and negative control group waits capacity solvent distilled water, and positive controls (Anshen Bunao mixture) gives 0.2ml/10g.Duration of test mouse freely ingests and drinks water, and weighs a body weight every 2d, adjusts gavage amount according to body weight.

2.2 swimming with a load attached to the body experiments

After administration 30d, after last gavage 30min, put small white mouse in glass cylinder (100cm × 60cm × 60cm) went swimming of swimming, the depth of water is not less than 30cm, 10 ± 1 DEG C of water temperatures, the sheet lead of mouse root of the tail portion load body weight 5%, records mouse and starts can not float the time to submerged 8s from swimming, and the power of being recorded as exhausts the time (min).Statistical procedures result is used represent, adopt SPSS17.0 software to carry out one-way analysis of variance processing.The results are shown in Table 3.

Table 3

Group	Swimming time (min)
		Negative control group (NCG)	5.20±2.18
Positive controls (CCG)	5.96±0.84
		Low amount group (LD)	7.95±2.35
Middle amount group (MD)	12.64±4.34*
		A large amount group (HD)	12.53±4.22*

(n=5, min, note; N is small white mouse quantity, for average swimming time, s is standard deviation)

Experimental result:

From table 3, each dosage group mouse swimming time all extends than control group, wherein, there were significant differences compared with negative control class value (* P<0.05) for high, middle dosage group, also there were significant differences compared with positive control class value (* P<0.05) for high, middle dosage group, between high, medium and low dosage group, difference is not remarkable, shows that the present composition has the mice burden swimming of prolongation time effect.

The determination experiment of 2.3 full blood lactic content

After centrifuge tube numbering used experiment, in each pipe, add 0.6mL protein precipitant, check the number and add the agent of 0.lmL anticoagulant heparin.

After last gavage 30min, get blood 0.1ml with syringe from small white mouse endocanthion, put into the test tube (getting for the first time blood) of the number of finishing.Handle well after wound, every small white mouse does not bear a heavy burden, and gets immediately blood after putting into swimming cylinder went swimming 30min, puts into the test tube (getting for the second time blood) of the number of finishing.Handle wound well, after small white mouse rest 20min, get again blood, put into the test tube (getting for the third time blood) of the number of finishing.Pour centrifuge tube into and leave standstill after 10min, centrifugal 8 minutes of turn/min of 3500-4000, gets supernatant and carries out Plasma lactate.

Measure lactic acid content according to the method for kit, record and analyze data.

At 530mm place, survey each pipe solution absorbance value with 721 spectrophotometers.Statistical procedures result is used represent, adopt SPSS17.0 software to carry out one-way analysis of variance processing.The results are shown in Table 4.

Table 4

(n=5, mmol/l, note; N is small white mouse quantity, for average lactic acid content, s is standard deviation)

Experimental result:

From table 4, before and after high dose group mouse movement, there were significant differences compared with negative control class value (* P<0.05) for three time point blood lactic acid TG-AUCs, before and after high dose group mouse movement three time point blood lactic acid TG-AUCs with in, compared with low dosage class value, there were significant differences (* P<0.05), all the other equal differences are not remarkable, show that the present invention strengthens immunity, fatigue-relieving composition and has the effect that reduces blood lactic acid TG-AUC after mouse movement.

By nanometer wall breaking technology preparation technology of the present invention, each raw material extract is beneficial to absorption of human body, has improved human absorptivity.Below obtain the availability data of Notogineng Extract for preparation technology of the present invention:

Table 5

The contrast of Notogineng Extract total saponin content prepared by the Notogineng Extract total saponin content that table 5 is prepared for technique of the present invention and common process, as can be seen from Table 5, the total saponin content of the Notogineng Extract that technique of the present invention is prepared with respect to the raising of common process 20～25%, the present invention uses after nanometer wall breaking technology raw materials, become the little molecule that human body can be absorbed, greatly improve the comprehensive utilization ratio of precious food materials.

Above disclosed is only preferred embodiment of the present invention, the interest field that certainly can not limit the present invention with this, and the equivalent variations of therefore doing according to the claims in the present invention, still belongs to the scope that the present invention is contained.

Claims (1)

1. one kind strengthens immunity, fatigue-relieving composition, it is characterized in that being made by following each component and content: 30～40 grams of pseudo-ginseng, Cordyceps sinensis or 10～15 grams of river in Zhejiang Province Chinese caterpillar funguses, 2～3 grams of lycopenes, 10～15 grams of glossy ganodermas, 10～15 grams of Morinda officinalis, 10～15 grams of the fruits of Chinese wolfberry, Organic Selenium 50～70 micrograms, vitamin A 550～650 micrograms, cobalamin 5～6 micrograms, 130～140 milligrams of vitamin Cs, 5～8 grams of all the other auxiliary materials, described auxiliary material is made up of starch or soy meal and sweetener;

This enhancing immunity, fatigue-relieving composition are made up of following steps:

(1) preparation of Notogineng Extract

A, get clean pseudo-ginseng, be cut into sheet, put in drying box 50～60 DEG C, establish constant temperature, dry 7～8 hours, pulverize, cross 20 mesh sieves; Again pulverize, cross 60 mesh sieves; Hydrolysis is extracted 2～3 times, merges extract; Use Rotary Evaporators is concentrated, obtains pseudo-ginseng extract powder;

B, pseudo-ginseng extract powder is placed on the shelf in the drying box of freeze drier, paving amount thickness is 1～2cm, opens refrigeration plant and vavuum pump, and the case internal pressure that keeps dry is 10～12Pa; By the cryovial in shelf, the temperature in drying box is adjusted to-39～-37 DEG C, freezing 2～3 hours;

C, drying box internal pressure is down to 1.0～1.2Pa, opens heating system, first shelf temperature is slowly heated to 7～8 DEG C from-39～-37 DEG C, this temperature-rise period is 8～10 hours; Slowly shelf temperature is adjusted to 25～28 DEG C more again, this temperature-rise period is 7～9 hours, obtains Radix Notoginseng powder dried frozen aquatic products after outlet, and Radix Notoginseng powder dried frozen aquatic products is made to 50～200 object fine powders in low temperature powder beater, obtains Notogineng Extract, for subsequent use;

(2) preparation of Cordyceps sinensis or river in Zhejiang Province Cordyceps, lycopene extract

A, get clean Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus, lycopene and put respectively in drying box 60 DEG C, freeze-day with constant temperature 4～5 hours, pulverizes, and crosses 60 mesh sieves; Hydrolysis extraction 2～3 times, merges clean Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus hydrolyzed extract and merges lycopene hydrolysis extract, uses Rotary Evaporators concentrated, obtains respectively Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus extract powder and lycopene extract powder;

B, Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus extract powder, lycopene extract powder are placed in respectively on the shelf in the drying box of freeze drier, paving amount thickness is 1～2cm, opens refrigeration plant and vavuum pump, and the case internal pressure that keeps dry is 10～12Pa; By the cryovial in shelf, the temperature in drying box is adjusted to-39～-37 DEG C, freezing 2～3 hours;

C, by drying box Pressure Drop to 1.0～1.2Pa, open heating system, first shelf temperature is slowly heated to 7～8 DEG C from-39～-37 DEG C, this temperature-rise period is 8～10 hours; Slowly shelf temperature is adjusted to 25～28 DEG C more again, this temperature-rise period is 7～9 hours, obtains respectively Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus powder dried frozen aquatic products, lycopene powder dried frozen aquatic products after outlet; Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus powder dried frozen aquatic products and lycopene powder dried frozen aquatic products are made to 50～200 object fine powders in low temperature powder beater, respectively Cordyceps sinensis or river in Zhejiang Province Cordyceps and lycopene extract, for subsequent use;

(3) preparation of Ganodenna Lucidum P.E

A, get clean glossy ganoderma and put in drying box 60 DEG C, freeze-day with constant temperature 8 hours, pulverizes, and crosses 20 mesh sieves; Again pulverize, cross 60 mesh sieves; Hydrolysis is extracted 2～3 times, merges extract, uses Rotary Evaporators concentrated, obtains glossy ganoderma extract powder;

B, glossy ganoderma extract powder is placed on the shelf in the drying box of freeze drier, paving amount thickness is 1cm, opens refrigeration plant and vavuum pump, and the case internal pressure that keeps dry is 10～12Pa; By the cryovial in shelf, the temperature in drying box is adjusted to-39～-37 DEG C, freezing 2～3 hours;

C, drying box internal pressure is down to 1.0～1.2Pa, opens heating system, first shelf temperature is slowly heated to 7～8 DEG C from-39～-37 DEG C, this temperature-rise period is 8～10 hours; Slowly shelf temperature is adjusted to 25～28 DEG C more again, this temperature-rise period is 7～9 hours, obtains glossy ganoderma powder dried frozen aquatic products after outlet, and glossy ganoderma powder dried frozen aquatic products low temperature powder beater is made to 50～200 object fine powders, obtains Ganodenna Lucidum P.E, for subsequent use;

(5) preparation of Morinda officinalis extract powder and Fructus Lycii extractum powder

Get put respectively in drying box 60 DEG C of clean Morinda officinalis, the fruit of Chinese wolfberry, freeze-day with constant temperature 8 hours, pulverizes, and crosses 20 mesh sieves; Again pulverize, cross 60 mesh sieves; Hydrolysis is extracted 2～3 times, and merging Morinda officinalis How and merging medlar extract liquid, use Rotary Evaporators concentrated, obtains respectively Morinda officinalis extract powder and Fructus Lycii extractum powder, for subsequent use;

(6) goods after total to Notogineng Extract, Cordyceps sinensis or river in Zhejiang Province Cordyceps, lycopene extract, Ganodenna Lucidum P.E, Morinda officinalis extract powder, Fructus Lycii extractum powder, Organic Selenium, vitamin A, cobalamin, vitamin C and all the other auxiliary materials mixing are carried out to compressing tablet on Highspeedrotarytabletpress;

(7) after compressing tablet, use chalk dust removal machine to go out powder on sheet, obtain qualified matrix band;

(8) obtaining after qualified matrix band, first carry out inner packing, tablet is carried out to aluminium-plastic bubble plate packing, carry out again external packing, the product aluminium-plastic panel pack sealing of the inner packing of learning from else's experience, mounted box, vanning, tape seal, packing, by quality testing department sampling inspection, warehouse-in after the assay was approved, deposits at dry, shady and cool place.