CN103271356A

CN103271356A - Composition for enhancing immunity and relieving physical fatigue and preparation method of composition

Info

Publication number: CN103271356A
Application number: CN2013102348185A
Authority: CN
Inventors: 刘聃
Original assignee: HAINAN TONGBAO INVESTMENT CO Ltd
Current assignee: HAINAN TONGBAO INVESTMENT CO Ltd
Priority date: 2013-06-14
Filing date: 2013-06-14
Publication date: 2013-09-04
Anticipated expiration: 2033-06-14
Also published as: CN103271356B

Abstract

The invention discloses a composition for enhancing immunity and relieving physical fatigue and a preparation method of the composition. The composition comprises the ingredients as follows: 30-40 g of pseudo-ginseng, 10-15 g of cordyceps sinensis or cordyceps militaris, 2-3 g of lycopene, 10-15 g of lucid ganoderma, 10-15 g of morinda officinalis, 10-15 g of boxthorn fruits, 50-70 mg of organic selenium, 550-650 mg of vitamin A, 125-126 mg of vitamin B, 130-140 mg of vitamin C and 5-8 g of other accessories. According to the composition and the preparation method, used raw material extracts are turned into micro molecules which can be absorbed by human bodies after a nanometer cell wall-breaking technology is used, the comprehensive utilization rate of precious ingredients is increased greatly, a scientific basis is provided for industrialized and standardized production, the product quality is controllable, and the curative effect can be fully developed. The composition has the functions in aspects such as air supplying and refreshing, immunity enhancing, oxidation and aging resistance, physical fatigue relief, assistance in memory improving, kidney tonifying, and the like. The flavor of the composition is easy to accept, the color and luster are pure and natural, the appearance is attractive and generous, and the composition is applicable to all age groups.

Description

A kind of enhancing immunity, alleviating physical fatigue composition and method of making the same

Technical field

The present invention relates to field of health care products, be specifically related to a kind of enriching blood and give birth to new, the capable stasis of blood of promoting blood circulation, the immunity that strengthens, anti-oxidant, anti-ageing, alleviating physical fatigue, auxiliary improvement of memory health products (highly condensed nutritious food) composition and method of making the same.

Background technology

On 05 19th, 2012 according to Xinhua News Agency's special despatch, to guide and to promote that Chinese health treatment industry sound development is " Chinese health treatment industry development report " issue in Beijing on the 18th in 05 month in 2012 of aim, this China stem health treatment blue book is by the China health care leader of association, the State-owned Assets Supervision and Administration Commission of State Council research center tissue lasts half a year and writes and forms.Show according to the data of quoting the seminar of Chinese international inferior health academy's successes in the blue book, account for 5% the people of Chinese true health, the shared total population ratio of sub-health state person is then up to 77%, and namely China's number of being in sub-health state has surpassed 700,000,000.

According to the definition of the World Health Organization to health, domestic and international research shows that modern society meets health standards person and accounts for about 15% of crowd's sum only.What is interesting is, be diagnosed as ill among the crowd, belong to also accounting for about 15% of unhealthy condition, if healthy and disease are regarded as the two ends of life process, it is just as a biapiculate olive so, middle protrude a bulk of is in healthy and ill transition state---inferior health between the two just, and 70% people is in sub-health state in the whole world population.Through rough estimates, China accounts for 8% of total income in the cost per capita aspect healthy, and this ratio of western developed country is about 6 times of China, and health products industry development potentiality are big.

We say usually and have suffered from disease, but " disease " is different with " disease " implication in ancient times." disease " refers to subtle minor illness (disease), if do not take effective measures, will develop into visible degree, just be called " disease ".This state that takes a disease, modern science claim " not sick " " inferior health " or " third state " in traditional Chinese medicine." sick " is not anosis, neither visible serious disease, and opinion is that the non-equilibrium state that negative and positive, qi and blood, internal organs battalion defend has appearred in health by traditional Chinese medical science viewpoint.Our ancestors recognize for a long time, had disease except positive searching except the method for disease, also accumulated the measure of many prevention illness.Huangdi's Internal Classics has day: " sage's preventing diseases instead for the treatment of diseases; husband's disease become then medicine it, disorderly become then to control it, is example still thirsty and wear well; make weapons after the fight has began, also evening? " the ancestors that can find out us thus brightly have recognized that to disease should " not rain silk fabric tassel, take preventive measures " important.

Inferior health is a kind of critical condition, is in the people of sub-health state, though there is not clear and definite disease, the decline of spiritual vigor and adaptive capacity occurs, if this state can not be corrected timely, is very easy to cause psychosomatic disease.Comprise: mental handicape, enterogastric diseases, hypertension, coronary heart disease, cancer, sexual function descend, burnout, absent minded, mood is irritated, insomnia, digestive function are bad, poor appetite, abdominal distension, nervous, uncomfortable in chest, constipation, suffer from diarrhoea, feel very tired out, even the dead sensation of desire is arranged.Yet physical examination there is no the problem on the organ, so mainly be functional problem.Be in the people of sub-health state, except tired and uncomfortable, can be in peril of one's life.If stimulate but run into highly, as under the stress situation such as stay up late, fly into a rage, being easy to occur sudden death, is exactly " overworking death "." overworking death "---be a kind of comprehensive disease, refer to that in the labout process under the non-physiological state people's operate as normal rule and rule of life are destroyed, tired alluvial and to the overwork state transitions in the body, make blood pressure rising, artery sclerosis aggravation, and then fatal state occurs.

The reason that causes inferior health is diversified, but the overtired first cause that is still.Along with the development of society, the progress of science and technology, the quickening of rhythm of life, the requirement abundant, cultural life of material life is more and more higher, inferior health from before, old artificial main body, develop into the generality state that comprises all orders of society, all ages now.Break away from the puzzlement of inferior health, people should guarantee rational meals and balanced nutrition, carry out moderate exercise, remove bad habit (smoking cessation limit wine), keep happy.

Pseudo-ginseng has another name called pseudo-ginseng, is described as " invaluable "." jade is seized the medicine solution " record: " with battalion hemostasis, the capable stasis of blood of promoting blood circulation, row hemostasis and the new blood of sword." supplementary Amplifications of the Compendium of Materia Medica record: " and ginseng qi-tonifying the first, pseudo-ginseng enrich blood the first, flavor with and merit also waits, so claim Panax pseudoginseng, be the most precious person of Chinese medicine." active ingredient of pseudo-ginseng hydrolysate is notoginsenoside, is topmost active component in the pseudo-ginseng, has the enhancing body's immunity, stronger antitumor activity arranged, anti-liver injury, anti-inflammatory properties; Promoting blood circulation to remove blood stasis is arranged, platelet aggregation-against, antithrombotic forms effect; Bidirectional modulation blood sugar is arranged, reduce blood fat, cholesterol, inhibition artery sclerosis function; Hemangiectasis is arranged, bring high blood pressure down, improve microcirculation, increase CBF, prevention and treatment heart and brain tissues ischemic, air hunger promote blood cell metabolism, the balance adjustment blood cell, and the bidirectional modulation nervous centralis, raising is mental, strengthens the learning and memory ability; Have to promote protein, ribonucleic acid (RNA), DNA (DNA) synthetic, improve the health delay senility, effect such as analgesia.

River in Zhejiang Province Chinese caterpillar fungus or Cordyceps sinensis are described as " east mountain balsam " and " kidney tonifying holy product ", are a kind of traditional high-grade nourishing rare traditional Chinese medicines, and multiple efficacies such as adjusting function of immune system, antitumor, antifatigue are arranged.The effect of " Xinhua's book on Chinese herbal medicine outline " record " it is sweet to distinguish the flavor of, and property is flat, and liver and kidney benefiting is arranged, and mends marrow, hemostasis and phlegm "." " the arteries and veins medicine connection pearl property of medicine is examined " record: " secret lean gas is specially mended the gate of vitality." " Chinese medicinal fungi " introduction: often edible Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus can promote digestion, regulate immunologic function, strengthen human body to the resistance of multiple disease.In the U.S., classify Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus as anti-cancer agent, enter clinical three phases.Modern study shows, Chinese caterpillar fungus mainly contains cordycepic acid, cordycepin, amino acid, sterol, sweet mellow wine, alkaloid, vitamin B1, B2, polysaccharide and mineral matter etc., has the immunity of organisms of raising, regulates immunity, delays senility, improves learning and memory, antitumaous effect; Cardiovascular system there is step-down, reduces MCO, improve myocardial ischemia, antiarrhythmic effect; Other position to health has the Conclusion Decreasing controlling nocturnal emission with astringent drugs, effect such as beneficial cloudy tonifying lung, antibiotic, tranquilizing soporific, nourishing.

Lycopene is described as " plant gold ", it is one of found powerful antioxidant in natural plant at present, can the cell growth metabolism play regulating and controlling effect, strengthen human immune system's prevention and suppress tumour, angiocardiopathy preventing and plurality of health care functions effect, can effectively preventing because of aging, the various diseases that immunity degradation causes.2003, U.S.'s Time was listed in lycopene first of " to the maximum food of human health contribution ", is called by western countries " plant gold ".Lycopene especially has remarkable result to preventing and treating prostate cancer, lung cancer, breast cancer, the cancer of the uterus etc., effectively suppress the diffusion of cancer cell and copy, can impel growth and the regeneration of cell, beauty treatment Eradicates wrinkle, keep skin health, delay senility, improve effects such as ability of learning and memory, it receives countries in the world expert's concern, now is widely accepted in American-European, Japanese and Chinese Hong Kong and Taiwan area.

Glossy ganoderma is described as " celestial grass ".Shennong's Herbal is classified glossy ganoderma as top grade, call purple sesame " main deaf, sharp joint, it is smart to protect refreshing benefit, hard muscles and bones, good color, clothes are made light of one's life by commiting suicide and are not prolonged life always for a long time." " bowl spares increases wisdom not to be forgotten for main knot in the heart, the beneficial motive, and food of a specified duration is made light of one's life by commiting suicide not old, prolongs life and becomes an immortal to call red sesame.Modern study shows; glossy ganoderma has antitumor action, is that best immunologic function is regulated and activator, has the hepatic injury that multiple physics and chemistry and biological factor are caused the protection detoxication is arranged; myocardial ischemia is had protective effect, can be widely used in treatment and the prevention of coronary heart disease, angina pectoris etc.To the high fat of blood patient, glossy ganoderma can obviously reduce cholesterolemia, lipoprotein and triglyceride, and the formation of energy prevention of arterial AP.The contained polysaccharide of glossy ganoderma, polypeptide etc. have tangible function of delaying senility.Glossy ganoderma just has been used for nervous breakdown and insomnia, so it plays good effect to maincenter.In the NF, glossy ganoderma is exactly the medicine of effectively sleeping peacefully and allaying excitement.

Morinda officinalis is one of four famous Da Nan medicines of China, and in antidotal medicine, Morinda officinalis is one of the most frequently used Chinese medicine, and the place of production common people have the food custom of " with meat pot together " for a long time, are described as " key medicine of tonifying kidney and strengthening yang "." book on Chinese herbal medicine converge " record: " be the medicine of kidney channel blood system, top capping help Yuanyang then stomach Qi grow, oneself moves back all void, but on its merit Ju Bi Collettii, the stem of noble dendrobium.Its property is heat how, and same golden cypress, the wind-weed be reinforcing yin essence then, and same desert cistanche, cynomorium songaricum are then supporing yang, expensive use the people avoid hot weather while using drugs of hot nature the avoiding cold wearher while using drugs of cold nature ear." Morinda officinalis have anti-ageing, strengthen immunity, regulate endocrine, improve learning memory and descend, promote effects such as hematopoiesis, antidepression, antitumor, anti-inflammatory, chill rheumatism, attenuation and analgesia.Especially diseases such as cold infertile, the irregular menstruation of impotence due to deficiency of the kidney, seminal emission premature ejaculation, few abdomen crymodynia, urinary incontinence, palace, wind-cold-dampness arthralgia, soreness and weakness of waist and knees, rheumatism limb gas, muscles and bones impotence is soft there is significant curative effect.

Matrimony vine is described as " medication tonic good merchantable brand " from ancient times.The Compendium of Material Medica record: " spring is adopted folium lycii, name day smart grass; Summer picks flowers, the name houseleek; Qiu Caizi, the name fruit of Chinese wolfberry; Dong Caigen, the name root bark of Chinese wolf-berry." " dietetic materia medica " record: " hard muscle is anti-old, except wind, help muscles and bones, can benefit go into, and removes consumptive disease." modern study shows, matrimony vine contains abundant carrotene, contains a large amount of retinol1s, B1, B2, C, and calcium, iron etc., is the essential nutriment of healthy eye, is commonly called as " bright eye is sub ".Antioxidant in the matrimony vine, beta carotene be prevention of cardiac and cancer effectively, and protection skin is avoided sun damage, and the blood sugar of reduction, hypotensive, lipotropy are arranged, and can antiatherosclerosis.

At present, the health products that have simple function on the market are existing multiple, as Radix Notoginseng powder, lucidum spore powder, lycopene sheet, Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus sheet etc., but market does not have corresponding compound product, the effect of pseudo-ginseng, glossy ganoderma, lycopene sheet, Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus is not brought into play, cause precious food materials to be wasted, make the consumer not obtain ideal product, form rational meals and balanced nutrition.

Summary of the invention

The purpose of this invention is to provide a kind of enhancing immunity, alleviated tired composition, said composition relates to the necessary nutrient minerals and vitamins of human body, and having enriches blood gives birth to functions such as new, the capable stasis of blood of promoting blood circulation, the immunity that strengthens, anti-oxidant, anti-ageing, alleviating physical fatigue, auxiliary improvement of memory, kidney tonifying.

To achieve these goals, technical scheme of the present invention is: a kind of enhancing immunity is provided, alleviates tired composition, comprise that following each composition divides and content: pseudo-ginseng 30～40 grams, Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus 10～15 grams, lycopene 2～3 grams, glossy ganoderma 10～15 grams, Morinda officinalis 10～15 restrain, the fruit of Chinese wolfberry 10～15 grams, organic selenium 50～70 micrograms, vitamin A 550～650 micrograms, cobalamin 5～6 micrograms, 130～140 milligrams of vitamin Cs, all the other auxiliary material 7～8 grams.

Described auxiliary material comprises starch or soy meal and sweetener.

Another object of the present invention is to provide a kind of enhancing immunity, alleviate tired preparation of compositions method, may further comprise the steps:

(1) preparation of Notogineng Extract

A, get clean pseudo-ginseng, be cut into sheet, put in the drying box 50～60 ℃, establish constant temperature, dry 7～8 hours, pulverize, cross 20 mesh sieves; Pulverize again, cross 60 mesh sieves; Hydrolysis is extracted 2～3 times, merges extract; The use Rotary Evaporators concentrates, and gets the pseudo-ginseng extract powder;

B, the pseudo-ginseng extract powder placed on the shelf in the drying box of freeze drier, shop amount thickness is 1～2cm, opens refrigeration plant and vavuum pump, and the case internal pressure that keeps dry is 10～12Pa; Be-39～-37 ℃ by the cryovial in the shelf with the adjustment in the drying box, freezing 2～3 hours;

C, the drying box internal pressure is down to 1.0～1.2Pa, opens heating system, earlier shelf temperature slowly is heated to 7～8 ℃ from-39～-37 ℃, this temperature-rise period is 8～10 hours; Slowly shelf temperature is transferred to 25～28 ℃ more again, this temperature-rise period is 7～9 hours, namely gets the Radix Notoginseng powder dried frozen aquatic products behind the outlet, and the Radix Notoginseng powder dried frozen aquatic products is made 50～200 purpose fine powders in the low temperature powder beater, namely gets Notogineng Extract, and is standby;

(2) preparation of Cordyceps sinensis or river in Zhejiang Province Cordyceps, lycopene extract

A, get clean Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus, lycopene and put in the drying box 60 ℃ respectively, freeze-day with constant temperature 4～5 hours is pulverized, and crosses 60 mesh sieves; Hydrolysis extraction 2～3 times merges clean Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus hydrolyzed extract and merges the lycopene hydrolysis extract, uses Rotary Evaporators to concentrate, and gets Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus extract powder and lycopene extract powder respectively;

B, Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus extract powder, lycopene extract powder placed respectively on the shelf in the drying box of freeze drier, shop amount thickness is 1～2cm, opens refrigeration plant and vavuum pump, and the case internal pressure that keeps dry is 10～12Pa; Be-39～-37 ℃ by the cryovial in the shelf with the adjustment in the drying box, freezing 2～3 hours;

C, drying box pressure is down to 1.0～1.2Pa, opens heating system, earlier shelf temperature slowly is heated to 7～8 ℃ from-39～-37 ℃, this temperature-rise period is 8～10 hours; Slowly shelf temperature is transferred to 25～28 ℃ more again, this temperature-rise period is 7～9 hours, gets Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus powder dried frozen aquatic products, lycopene powder dried frozen aquatic products behind the outlet respectively; Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus powder dried frozen aquatic products and lycopene powder dried frozen aquatic products are made 50～200 purpose fine powders in the low temperature powder beater, respectively Cordyceps sinensis or river in Zhejiang Province Cordyceps and lycopene extract, standby;

(3) preparation of Ganodenna Lucidum P.E

A, get clean glossy ganoderma and put in the drying box 60 ℃, freeze-day with constant temperature 8 hours is pulverized, and crosses 20 mesh sieves; Pulverize again, cross 60 mesh sieves; Hydrolysis is extracted 2～3 times, merges extract, uses Rotary Evaporators to concentrate, and gets the glossy ganoderma extract powder;

B, the glossy ganoderma extract powder placed on the shelf in the drying box of freeze drier, shop amount thickness is 1cm, opens refrigeration plant and vavuum pump, and the case internal pressure that keeps dry is 10～12Pa; Be-39～-37 ℃ by the cryovial in the shelf with the adjustment in the drying box, freezing 2～3 hours;

C, the drying box internal pressure is down to 1.0～1.2Pa, opens heating system, earlier shelf temperature slowly is heated to 7～8 ℃ from-39～-37 ℃, this temperature-rise period is 8～10 hours; Slowly shelf temperature is transferred to 25～28 ℃ more again, this temperature-rise period is 7～9 hours, namely gets the glossy ganoderma powder dried frozen aquatic products behind the outlet, and glossy ganoderma powder dried frozen aquatic products low temperature powder beater is made 50～200 purpose fine powders, namely gets Ganodenna Lucidum P.E, and is standby;

(5) preparation of Morinda officinalis extract powder and Fructus Lycii extractum powder

Get put respectively in the drying box 60 ℃ of clean Morinda officinalis, the fruit of Chinese wolfberry, freeze-day with constant temperature 8 hours is pulverized, and crosses 20 mesh sieves; Pulverize again, cross 60 mesh sieves; Hydrolysis is extracted 2～3 times, and merging Morinda officinalis extract and merging medlar extract liquid use Rotary Evaporators to concentrate, and get Morinda officinalis extract powder and Fructus Lycii extractum powder respectively, and be standby;

(6) goods after Notogineng Extract, Cordyceps sinensis or river in Zhejiang Province Cordyceps, lycopene extract, Ganodenna Lucidum P.E, Morinda officinalis extract powder, Fructus Lycii extractum powder, organic selenium, vitamin A, cobalamin, vitamin C and all the other auxiliary materials are always mixed carry out compressing tablet at Highspeedrotarytabletpress; (the present invention makes capsule, oral liquid, pill employing conventional means, does not state in detail at this)

(7) use the gumming machine to go out powder on the sheet behind the compressing tablet, namely get qualified matrix band;

(8) after obtaining qualified matrix band, carry out inner packing earlier, tablet is carried out aluminium-plastic bubble plate packing, carry out external packing again, the pack of the product aluminium-plastic panel of the inner packing of learning from else's experience seals, adorns box, vanning, tape seal, packing, by the quality testing department sampling inspection, warehouse-in is deposited at dry, shady and cool place after the assay was approved.

Said composition can be made tablet, capsule, oral liquid, pill.

After the present invention uses the nanometer wall breaking technology to used raw material, become the little molecule that human body can be absorbed, greatly improve the comprehensive utilization ratio of precious food materials, for industrialization, standardized production provide scientific basis, make controllable product quality, can give full play to curative effect, this product is developed at sub-health population exactly, functional, use crowd scope covers extensively, has filled up the domestic and international blank of this series products realization standardized production, has good market prospects.The necessary nutrient minerals and vitamins of human body involved in the present invention has invigorating qi and refreshing, strengthens immunity, the function of aspects such as anti-oxidant, anti-ageing, alleviating physical fatigue, auxiliary improvement of memory, kidney tonifying.The present composition uses crowd's scope to cover extensively, and is functional, and taste is easy to accept, and color and luster is honest natural, elegant in appearance, goes for all ages.By nanometer wall breaking technology preparation technology of the present invention, each raw material extract is beneficial to absorption of human body, has improved the human absorptivity.

The specific embodiment

Embodiment 1

In per 100 gram present compositions, contain pseudo-ginseng 40 grams, Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus 10 grams, lycopene 2 grams, glossy ganoderma 10 grams, Morinda officinalis 15 grams, the fruit of Chinese wolfberry 15 grams, organic selenium 60 micrograms, vitamin A 600 micrograms, cobalamin 6 micrograms, 140 milligrams of vitamin Cs, auxiliary material such as starch or soy meal, sweetener 6～7 grams (because of shared shortage in weight 1 gram in per 100 grams of nutrient prime replenishers such as organic selenium, vitamin, the other parts of its less than 1 gram are supplied with auxiliary material).

Preparation process:

1, get clean out pseudo-ginseng put in the drying box 60 ℃ of freeze-day with constant temperature 8 hours, pulverize, cross 20 mesh sieves; Pulverize again, cross 60 mesh sieves; Hydrolysis is extracted 2 times, merges extract, uses Rotary Evaporators to concentrate, and gets the pseudo-ginseng extract powder.Then, the pseudo-ginseng extract powder is placed on the shelf in the drying box of freeze drier, shop amount thickness is 1cm, open refrigeration plant and vavuum pump, the case internal pressure that keeps dry is 10Pa, is-39～-37 ℃ by the cryovial in the shelf with the adjustment in the drying box, freezing 2 hours; Again the pressure in the drying box is down to 1.0Pa; Open heating system, earlier shelf temperature slowly is heated to 7～8 ℃, about 8～10 hours of this temperature-rise period from-39～-37 ℃; Slowly shelf temperature is transferred to 25～28 ℃ more again, about 7～9 hours of this process namely gets the Radix Notoginseng powder dried frozen aquatic products behind the outlet, dried frozen aquatic products low temperature powder beater is made 50～200 purpose fine powders, namely gets Notogineng Extract, and is standby.

2, get clean out glossy ganoderma put in the drying box 60 ℃ of freeze-day with constant temperature 8 hours, pulverize, cross 20 mesh sieves; Pulverize again, cross 60 mesh sieves; Hydrolysis is extracted 2～3 times, merges extract, uses Rotary Evaporators to concentrate, and gets extract powder.Then, the glossy ganoderma extract powder is placed on the shelf in the drying box of freeze drier, shop amount thickness is 1cm, opens refrigeration plant and vavuum pump, and the case internal pressure that keeps dry is 10～12Pa; Be-39～-37 ℃ by the cryovial in the shelf with the adjustment in the drying box, freezing 2～3 hours, again pressure be down to 1.0～1.2Pa; Open heating system, earlier shelf temperature slowly is heated to 7～8 ℃, about 8～10 hours of this process from-39～-37 ℃; Slowly shelf temperature is transferred to 25～28 ℃ again, about 7～9 hours of this process namely gets the glossy ganoderma powder dried frozen aquatic products behind the outlet, dried frozen aquatic products low temperature powder beater is made 50～200 purpose fine powders, namely gets Ganodenna Lucidum P.E, and is standby.

3, get the lycopene finished product that originates from Xinjiang of cleaning out Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus and meeting the raw material requirement and put in the drying box 60 ℃ respectively, freeze-day with constant temperature 4 hours is pulverized, and crosses 60 mesh sieves; Hydrolysis is extracted 2～3 times, merges extract separately respectively, uses Rotary Evaporators to concentrate, and gets Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus extract powder and lycopene extract powder respectively.Then, Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus extract powder, lycopene extract powder are placed respectively on the shelf in the drying box of freeze drier, shop amount thickness is 1cm, opens refrigeration plant and vavuum pump, and the case internal pressure that keeps dry is 10～12Pa; Be-39～-37 ℃ by the cryovial in the shelf with the adjustment in the drying box, freezing 2～3 hours; Again the pressure in the drying box is down to 1.0～1.2Pa; Open heating system, earlier shelf temperature slowly is heated to 7～8 ℃, about 8～10 hours of this process from-39～-37 ℃; Slowly shelf temperature is transferred to 25～28 ℃ again, about 7～9 hours of this process, get Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus powder dried frozen aquatic products and lycopene powder dried frozen aquatic products behind the outlet respectively, dried frozen aquatic products low temperature powder beater is made 50～200 purpose fine powders, namely get Cordyceps sinensis or river in Zhejiang Province Cordyceps, lycopene extract, standby.

4, get put in the drying box 60 ℃ of cleaning out Morinda officinalis, the fruit of Chinese wolfberry, freeze-day with constant temperature 8 hours is pulverized, and crosses 20 mesh sieves; Pulverize again, cross 60 mesh sieves; Hydrolysis is extracted 2～3 times, merges extract, uses Rotary Evaporators to concentrate, and gets Morinda officinalis extract powder and Fructus Lycii extractum powder, and is standby.

5, carry out compatibility according to the proportion compatibility in the instantiation 1 of the present invention, Notogineng Extract, Cordyceps sinensis or river in Zhejiang Province Cordyceps, lycopene extract, Ganodenna Lucidum P.E, Morinda officinalis extract powder, Fructus Lycii extractum powder, organic selenium powder, vitamin A powder, cobalamin powder, vitamin c powder and all the other auxiliary materials is evenly total mixed; Total step of mixing is according to common process;

6, the goods after will always mixing carry out compressing tablet at Highspeedrotarytabletpress;

7, use the gumming machine to go out powder on the sheet behind the compressing tablet, matrix band namely;

8, after obtaining qualified matrix band, carry out inner packing earlier, tablet is carried out aluminium-plastic bubble plate packing, carry out external packing again, the pack of the product aluminium-plastic panel of the inner packing of learning from else's experience seals, adorns box, vanning, tape seal, packing, by the quality testing department sampling inspection, warehouse-in is deposited at dry, shady and cool place after the assay was approved.

9, can obtain the product produced according to the proportion compatibility in the instantiation 1 of the present invention.

Embodiment 2

In per 100 gram said compositions, contain pseudo-ginseng 30 grams, Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus 15 grams, lycopene 2 grams, glossy ganoderma 15 grams, Morinda officinalis 15 grams, the fruit of Chinese wolfberry 15 grams, organic selenium 60 micrograms, vitamin A 600 micrograms, cobalamin 6 micrograms, 140 milligrams of vitamin Cs, about 6～7 grams of auxiliary material such as starch or soy meal, sweetener (because of shared shortage in weight 1 gram in per 100 grams of nutrient prime replenishers such as organic selenium, vitamin, the other parts of its less than 1 gram are supplied with auxiliary material).

5, carry out compatibility according to the proportion compatibility in the instantiation 2 of the present invention, Notogineng Extract, Cordyceps sinensis or river in Zhejiang Province Cordyceps, lycopene extract, Ganodenna Lucidum P.E, Morinda officinalis extract powder, Fructus Lycii extractum powder, organic selenium powder, vitamin A powder, cobalamin powder, vitamin c powder and all the other auxiliary materials is evenly total mixed; Total step of mixing is according to common process;

9, can obtain the product produced according to the proportion compatibility in the instantiation 2 of the present invention.

Embodiment 3

In per 100 gram said compositions, contain pseudo-ginseng 35 grams, Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus 15 grams, lycopene 3 grams, glossy ganoderma 14 grams, Morinda officinalis 13 grams, the fruit of Chinese wolfberry 15 grams, organic selenium 55 micrograms, vitamin A 600 micrograms, cobalamin 6 micrograms, 130 milligrams of vitamin Cs, about 5～6 grams of auxiliary material such as starch or soy meal, sweetener (because of shared shortage in weight 1 gram in per 100 grams of nutrient prime replenishers such as organic selenium, vitamin, the other parts of its less than 1 gram are supplied with auxiliary material).

1, get clean out pseudo-ginseng put in the drying box 60 ℃ of freeze-day with constant temperature 8 hours, pulverize, cross 20 mesh sieves; Pulverize again, cross 60 mesh sieves; Hydrolysis is extracted 3 times, merges extract, uses Rotary Evaporators to concentrate, and gets the pseudo-ginseng extract powder.Then, the pseudo-ginseng extract powder is placed on the shelf in the drying box of freeze drier, shop amount thickness is 1cm, open refrigeration plant and vavuum pump, the case internal pressure that keeps dry is 10Pa, is-39 ℃ by the cryovial in the shelf with the adjustment in the drying box, freezing 2 hours; Again the pressure in the drying box is down to 1.0Pa; Open heating system, earlier shelf temperature slowly is heated to 7 ℃, about 8 hours of this temperature-rise period from-39 ℃; Slowly shelf temperature is transferred to 25 ℃ more again, about 7 hours of this process namely gets the Radix Notoginseng powder dried frozen aquatic products behind the outlet, dried frozen aquatic products low temperature powder beater is made 200 purpose fine powders, namely gets Notogineng Extract, and is standby.

2, get clean out glossy ganoderma put in the drying box 60 ℃ of freeze-day with constant temperature 8 hours, pulverize, cross 20 mesh sieves; Pulverize again, cross 60 mesh sieves; Hydrolysis is extracted 3 times, merges extract, uses Rotary Evaporators to concentrate, and gets extract powder.Then, the glossy ganoderma extract powder is placed on the shelf in the drying box of freeze drier, shop amount thickness is 1cm, opens refrigeration plant and vavuum pump, and the case internal pressure that keeps dry is 12Pa; Be-37 ℃ by the cryovial in the shelf with the adjustment in the drying box, freezing 3 hours, again pressure be down to 1.2Pa; Open heating system, earlier shelf temperature slowly is heated to 8 ℃, about 10 hours of this process from-37 ℃; Slowly shelf temperature is transferred to 28 ℃ again, about 9 hours of this process namely gets the glossy ganoderma powder dried frozen aquatic products behind the outlet, dried frozen aquatic products low temperature powder beater is made 100 purpose fine powders, namely gets Ganodenna Lucidum P.E, and is standby.

3, get the lycopene finished product that originates from Xinjiang of cleaning out Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus and meeting the raw material requirement and put in the drying box 60 ℃ respectively, freeze-day with constant temperature 4 hours is pulverized, and crosses 60 mesh sieves; Hydrolysis is extracted 2～3 times, merges extract separately respectively, uses Rotary Evaporators to concentrate, and gets Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus extract powder and lycopene extract powder respectively.Then, Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus extract powder, lycopene extract powder are placed respectively on the shelf in the drying box of freeze drier, shop amount thickness is 1cm, opens refrigeration plant and vavuum pump, and the case internal pressure that keeps dry is 11Pa; Be-39 ℃ by the cryovial in the shelf with the adjustment in the drying box, freezing 3 hours; Again the pressure in the drying box is down to 1.0Pa; Open heating system, earlier shelf temperature slowly is heated to 8 ℃, about 10 hours of this process from-39 ℃; Slowly shelf temperature is transferred to 25 ℃ again, about 7 hours of this process gets Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus powder dried frozen aquatic products and lycopene powder dried frozen aquatic products respectively behind the outlet, dried frozen aquatic products low temperature powder beater is made 150 purpose fine powders, namely get Cordyceps sinensis or river in Zhejiang Province Cordyceps, lycopene extract, standby.

5, carry out compatibility according to the proportion compatibility in the instantiation 3 of the present invention, Notogineng Extract, Cordyceps sinensis or river in Zhejiang Province Cordyceps, lycopene extract, Ganodenna Lucidum P.E, Morinda officinalis extract powder, Fructus Lycii extractum powder, organic selenium powder, vitamin A powder, cobalamin powder, vitamin c powder and all the other auxiliary materials is evenly total mixed; Total step of mixing is according to common process;

9, can obtain the product produced according to the proportion compatibility in the instantiation 3 of the present invention.

Health products of the present invention (highly condensed nutritious food) composition, in this product formula range, below prescription is the per day for adults consumption, comprise following supplementary material: pseudo-ginseng 1～9 gram, Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus 1～9 gram, 7～20 milligrams of lycopenes, glossy ganoderma 2～12 grams, Morinda officinalis 2～10 grams, the fruit of Chinese wolfberry 2～12 grams, organic selenium 15～70 micrograms, dehydroretinol 50～500 micrograms, cobalamin 1～5 microgram, 30～400 milligrams of vitamin Cs, auxiliary materials such as starch or soy meal, sweetener 2～8 grams.Can debug according to different proportion according to different demands.Can be unit according to kilogram or ton when large-scale production, small-scale production can be unit with the gram, and weight can increase or reduce.Follow preparation method of the present invention, can obtain this formulation product.

Strengthen the immunity experiment: the present invention confirms to have the effect that strengthens immunity, experimental result and conclusion through animal experiment:

1, the present invention is to the influence of DNFB inducing mouse DTH

The present invention that per os gives the mouse various dose strengthens immunity, alleviates tired composition (tablet) after 1 month, the auricular concha weightening finish is through the variance test of homogeneity, satisfy the homogeneity of variance requirement, comparative approach in twos with mean between a plurality of experimental group in the one-way analysis of variance method and control group carries out statistical disposition, and is as shown in table 1:

Table 1 present composition to the influence of DNFB inducing mouse DTH ( )

By table 1 result as seen, the weightening finish of 150mg/kgbw group auricular concha is significantly higher than the 0mg/kgbw group.

2, the present invention strengthens immunity, alleviates tired composition to the influence of NK cells in mice activity

Per os gives the present composition tablet 1 month of mouse various dose, (P is the NK cytoactive to the NK cytoactive through sin-1P1/2, expression decimally) carries out normal distribution, homogeneity test of variance after the conversion, satisfy the normal distribution requirement, comparative approach in twos with a plurality of experimental group in the one-way analysis of variance method and a control group mean carries out statistical disposition, and is as shown in table 2:

Table 2 present composition to the influence of NK cells in mice activity (

)

By table 2 result as seen, 50mg/kgbw, 150mg/kgbw group NK cytoactive is significantly higher than the 0mg/kgbw group.

3, conclusion

1. cellular immune function: the weightening finish of 150mg/kgbw group auricular concha is significantly higher than the 0mg/kgbw group in the experiment of DNFB inducing mouse DTH.

2. NK cytoactive: 50mg/kgbw, 150mg/kgbw group NK cytoactive is significantly higher than the 0mg/kgbw group in the NK cells in mice determination of activity experiment.

The experiment of small white mouse antifatigue:

Show that through zoopery enhancing immunity of the present invention, the tired composition of alleviation have significant anti-fatigue effect.

1, experimental animal

75 healthy and strong male white mouses, body weight 25 ± 2g.The experimental session all animals cleans level mouse pellet and aqua sterilisa freely eats.

2, test method

2.1 dosage and grouping

The used animal of swimming test and every biochemical indicator (full blood lactic, hepatic glycogen, serum urea nitrogen) all respectively is divided into 5 groups to small white mouse by body weight, i.e. negative (distilled water) control group (NCG), positive (Anshen Bunao mixture) control group (CCG), Millettia speciosa Champ.extract hangs down amount group (LD), middle amount group (MD), a large amount group (HD), 15 every group.According to the small white mouse body weight, present composition 100mg/kg is low amount group, and 200mg/kg is middle amount group, and 600mg/kg is a large amount group.Mouse continuous irrigation stomach 30d, experimental group gives respectively to organize the present composition, and negative control group waits capacity solvent distilled water, and positive controls (Anshen Bunao mixture) gives 0.2ml/10g.The duration of test mouse freely ingests and drinks water, and every body weight of 2d weighing, irritates the stomach amount according to the body weight adjustment.

2.2 swimming with a load attached to the body experiment

Behind the administration 30d, after last is irritated stomach 30min, put small white mouse in the glass cylinder (swimming among 100cm * 60cm * 60cm) of swimming, the depth of water is not less than 30cm, 10 ± 1 ℃ of water temperatures, the sheet lead of mouse root of the tail portion load body weight 5%, the record mouse begins can not float the time to submerged 8s from swimming, and the power of being recorded as exhausts the time (min).Statistical procedures result uses

Expression is adopted SPSS17.0 software to carry out one-way analysis of variance and is handled.The results are shown in Table 3.

Table 3

Group	Swimming time (min)
		Negative control group (NCG)	5.20±2.18
Positive controls (CCG)	5.96±0.84
		Low amount group (LD)	7.95±2.35
Middle amount group (MD)	12.64±4.34*
		A large amount group (HD)	12.53±4.22*

(n=5, min,

Annotate; N is small white mouse quantity,

Be average swimming time, s is standard deviation)

Experimental result:

By table 3 as seen, each dosage group mouse swimming time all prolongs than control group, wherein, high, middle dosage group compares with the negative control class value that there were significant differences (* P＜0.05), high, middle dosage group compares with the positive control class value that also there were significant differences (* P＜0.05), difference is not remarkable between the high, medium and low dosage group, shows that the present composition has the mouse of prolongation swimming with a load attached to the body time effect.

2.3 full blood lactic Determination on content experiment

After the used centrifuge tube numbering of experiment, in each pipe, add the 0.6mL protein precipitant, checking the number adds the agent of 0.lmL anticoagulant heparin.

Last is got blood 0.1ml with syringe from the small white mouse endocanthion after irritating stomach 30min, puts into the test tube (getting blood for the first time) of the number of finishing.After handling wound well, every small white mouse does not bear a heavy burden, and gets blood immediately after putting into swimming cylinder swimming 30min, puts into the test tube (getting blood for the second time) of the number of finishing.Handle wound well, treat to get blood again behind the small white mouse rest 20min, put into the test tube (getting blood for the third time) of the number of finishing.After pouring centrifuge tube into and leaving standstill 10min, centrifugal 8 minutes of 3500-4000 commentaries on classics/min gets supernatant and carries out lactic acid and measure.

Method according to kit is measured lactic acid content, and record is also analyzed data.

, survey and respectively manage the solution absorbance value at the 530mm place with 721 spectrophotometers.Statistical procedures result uses

Expression is adopted SPSS17.0 software to carry out one-way analysis of variance and is handled.The results are shown in Table 4.

Table 4

(n=5, mmol/l,

Annotate; N is small white mouse quantity,

Be average lactic acid content, s is standard deviation)

Experimental result:

By table 4 as seen, three time point blood lactic acid TG-AUCs compare with the negative control class value that there were significant differences (* P＜0.05) before and after the high dose group mouse movement, before and after the high dose group mouse movement three time point blood lactic acid TG-AUCs with in, the low dosage class value compares that there were significant differences (* P＜0.05), all the other equal differences are not remarkable, show that the present invention strengthens immunity, alleviates tired composition and have the effect that reduces blood lactic acid TG-AUC behind the mouse movement.

By nanometer wall breaking technology preparation technology of the present invention, each raw material extract is beneficial to absorption of human body, has improved the human absorptivity.Below obtain the utilization rate data of Notogineng Extract for preparation technology of the present invention:

Table 5

The contrast of the Notogineng Extract total saponin content that table 5 prepares for the Notogineng Extract total saponin content of technology of the present invention preparation and common process, as can be seen from Table 5, the total saponin content of the Notogineng Extract that technology of the present invention is prepared with respect to the raising of common process 20～25%, after the present invention uses the nanometer wall breaking technology to used raw material, become the little molecule that human body can be absorbed, greatly improve the comprehensive utilization ratio of precious food materials.

Above disclosed only is preferred embodiment of the present invention, can not limit the present invention's interest field certainly with this, and therefore the equivalent variations of doing according to claim of the present invention still belongs to the scope that the present invention is contained.

Claims

1. one kind strengthens immunity, alleviates tired composition, it is characterized in that, comprise that following each composition divides and content: pseudo-ginseng 30～40 grams, Cordyceps sinensis or river in Zhejiang Province Chinese caterpillar fungus 10～15 grams, lycopene 2～3 grams, glossy ganoderma 10～15 grams, Morinda officinalis 10～15 restrain, the fruit of Chinese wolfberry 10～15 grams, organic selenium 50～70 micrograms, vitamin A 550～650 micrograms, cobalamin 5～6 micrograms, 130～140 milligrams of vitamin Cs, all the other auxiliary material 5～8 grams.

Enhancing immunity as claimed in claim 1, alleviate tired composition, it is characterized in that: described auxiliary material comprises starch or soy meal and sweetener.

3. enhancing immunity as claimed in claim 1, the tired preparation of compositions method of alleviation is characterized in that, may further comprise the steps:

(1) preparation of Notogineng Extract

(3) preparation of Ganodenna Lucidum P.E

(6) goods after Notogineng Extract, Cordyceps sinensis or river in Zhejiang Province Cordyceps, lycopene extract, Ganodenna Lucidum P.E, Morinda officinalis extract powder, Fructus Lycii extractum powder, organic selenium, vitamin A, cobalamin, vitamin C and all the other auxiliary materials are always mixed carry out compressing tablet at Highspeedrotarytabletpress;

Enhancing immunity as claimed in claim 3, alleviate tired preparation of compositions method, it is characterized in that: said composition can be made tablet, capsule, oral liquid, pill.