CN101884783A - Wheat bran polypeptide-containing anti-fatigue traditional Chinese medicine and preparation method thereof - Google Patents
Wheat bran polypeptide-containing anti-fatigue traditional Chinese medicine and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a wheat bran polypeptide-containing anti-fatigue traditional Chinese and a preparation method thereof. The invention adopts a technical scheme that the wheat bran polypeptide-containing anti-fatigue traditional Chinese medicine is prepared from the following raw materials in part by weight: 7 to 9 parts of wheat bran polypeptide, 3 to 5 parts of aweto, 1 to 3 parts of radix astragali and 1 to 3 parts of barbary wolfberry fruit. The preparation method of the invention comprises the following steps of: extracting wheat bran protein, performing enzymolysis to prepare wheat bran polypeptide, refrigerating and drying the wheat bran polypeptide to prepare powder, completely homogenizing the powder with the aweto, the radix astragali and the barbary wolfberry fruit according to a weight ratio, and preparing the mixture into tablets, granules, pills or capsules. The traditional Chinese medicine contains rich polypeptide, saponins, polysaccharides, vitamins, trace elements and the like and has an obvious anti-fatigue effect on valetudinary middle-aged and elderly people with low immunity and easily fatigue.
Description
Technical field
The invention belongs to field of health care products, relate to particularly and a kind ofly have the Chinese medicine health care product of anti-fatigue effect about Testa Tritici polypeptide and Chinese crude drug compatibility.
Background technology
Along with the quickening of modern people's rhythm of life, huge variation is just taking place in people's life style, the working time lengthening, and pressure is increasing, and competition is fierce more.Allegro life makes increasing urbanite enjoy the hardship of tired and pressure.The disease that these exist already in western countries is just causing the concern of Chinese health circle and nutrition circle.Therefore, the birth of effective anti-fatigue health-product containing is called in market.
Modern nutriology is discovered: the mankind ingest protein after gastral enzyme effect, digest and assimilate with little peptide form mostly, and the ratio that absorbs with the free amino acid form is very little.And the digestion of little peptide specific ionization aminoacid is faster, absorbs manyly, shows that the biological value of peptide and nutritive value specific ionization aminoacid are higher.Because the aminoacid difference of peptide class, its function and biological effect are also different, bioactive peptide has multiple body metabolism and physiological regulation function, easily digest and assimilate, effects such as enhancing immunity, hormonal regulation, resisting fatigue, antibiotic, antiviral, blood pressure lowering and blood fat reducing are arranged, edible safety is high, is the most popular research topic of current international food circle and the functional factor that has development prospect.
Summary of the invention
The objective of the invention is to make full use of Testa Tritici polypeptide and Chinese crude drug compatibility, developing a kind ofly has and should, have anti-fatigue effect health, but the Chinese medicine health care product that long-term safety is taken.
To achieve these goals, the technical solution used in the present invention is: a kind of anti-fatigue Chinese medicine that contains Testa Tritici polypeptide, make medicament by weight ratio by following raw material:
Testa Tritici polypeptide 7-9 part,
Cordyceps 3-5 part,
Radix Astragali 1-3 part,
Fructus Lycii 1-3 part.
The above-mentioned anti-fatigue Chinese medicine that contains Testa Tritici polypeptide can be made medicaments such as tablet, pill, electuary or capsule.
Primary technology of the present invention is the preparation of Testa Tritici polypeptide, and Testa Tritici polypeptide is the by-product with wheat processing---Testa Tritici is raw material, extracts Testa Tritici albumen by alkaline process, makes Testa Tritici polypeptide after the compound enzyme fractional hydrolysis, and concrete preparation method is as follows:
1. raw material: remaining Testa Tritici after the wheat processing;
2. alkaline process extracts Testa Tritici albumen: Testa Tritici is pulverized with pulverizer, adds the proportioning of 10～20mlNaOH solution by every gram Testa Tritici, adds the NaOH solution of pH 11, extracting temperature is 45～55 ℃, time is 2～3 hours, centrifugal collecting precipitation, and lyophilization makes the Testa Tritici protein powder.
3. compound enzyme fractional hydrolysis: prepare Testa Tritici polypeptide with alkaline protease and compound protease fractional hydrolysis.Get Testa Tritici albumen, at first carry out enzymolysis with alkaline protease, enzymatic hydrolysis condition is: pH 8, and enzyme addition alive is the 6000u/g material, time 2.5～3.5h, 50 ℃ of temperature; Add compound protease then and carry out enzymolysis, enzymatic hydrolysis condition is: pH6, and enzyme addition alive is the 6000u/g material, time 1～1.5h, 55 ℃ of temperature; Enzymolysis solution behind the enzymolysis is heated to 100 ℃, keeps 10 minutes to kill the vigor of enzyme;
4. ultrafiltration: adopting molecular cut off is the enzymolysis solution of 10kDa ultrafiltration plate ultrafiltration step 3 preparations, and collecting molecular weight is the following enzymolysis solution of 10kDa;
5. lyophilization: the enzymolysis solution that step 4 is obtained makes the Testa Tritici polypeptide powder with low-temperature freeze-drying machine.
The present invention, the preparation method of anti-fatigue Chinese medicine that contains Testa Tritici polypeptide is as follows:
Cordyceps, the Radix Astragali, Fructus Lycii are put into Lowtemperaturepulverizer respectively to be pulverized; With the Testa Tritici polypeptide is major ingredient, and apolegamy Cordyceps, the Radix Astragali, Fructus Lycii are adjuvant, by above-mentioned weight portion proportioning, and abundant homogenizing; Make medicaments such as tablet, pill, electuary or capsule by prior art.
Among the present invention,
Semen Tritici aestivi, as one of most important cereal crops in the world, it is staple food with the Semen Tritici aestivi that 1/3 above population is arranged.Testa Tritici is the main side-product of flour processing, and Testa Tritici also contains the protein more than 15% except that compositions such as starch-containing, fiber, be a kind of potential plant protein resource.Albumin and globulin content height have higher lysine content in the Testa Tritici protein, and contain the necessary several amino acids of human body, are a kind of high-quality proteins.Its protein efficiency ratio, digestibility all are higher than soybean protein.International scientific circle is discovered, protein mainly is the form absorption with small peptide after the hydrolysis of digestive tract enzymatic, and absorbed, utilize by body than complete free amino acid is easier, faster, some little peptide can not only provide people's bulk-growth, grow needed nutrient substance, and have the unique biological function, can prevent and treat thrombosis, hyperlipidemia and hypertension, slow down aging, resisting fatigue, human body immunity improving power.
Testa Tritici polypeptide is the directed shearing technique preparation of utilization enzyme, by two enzymes (alkaline protease and compound protease) fractional hydrolysis Testa Tritici albumen, obtain " natural, safe, effective, high activity, high function, product property are stable " Testa Tritici polypeptide, kept many good characteristics of Testa Tritici polypeptide to greatest extent.
Cordyceps claims Cordyceps, Cordyceps again, and it is a kind of traditional famous and precious tonic Chinese medicine material, is listed as three big tonic with natural ginseng, Cornu Cervi Pantotrichum.Its property of medicine gentleness, equal edible throughout the year, the old or young, sick, weak, virtual person is all suitable, than the tonic of other kinds medical value is widely arranged.It contains 18 seed amino acids and the various trace elements of needed by human.Its composition has: crude protein, several amino acids, D-mannitol i.e. " cordycepic acid ", Cordycepin, ergosterol, galactomannan, uracil, adenine etc.As far back as a Seventh Five-Year Plan record of " Cordyceps Gan Pingbao lung, kidney tonifying are mended marrow, hemostasis and phlegm, phthisical cough, it is all good to control diaphragm disease " was just arranged in 7 years in " Bencao Congxin ".Modern science has been found the increasing magical effect of Cordyceps.It has regulates heart, liver, kidney, immune system, respiratory system function, and directly antitumor, antivirus action can improve cellular energy, have resisting fatigue, regulate the central nervous system effects such as sexual function of unifying.Cordyceps can play so comprehensively health-care effect to human body, so the laudatory title of " Herba mesonae chinensis " is arranged since ancient times, and can be used with multiple tonification food and strengthen its effect, also can with eliminating evil medicine partner treatment simulataneous insufficiency and excessive disease.In modern society, take Cordyceps and be not only healthy assurance itself, prior, be the ultimate attainment healthy living quality of bringing thus.
The Radix Astragali has another name called Radix Astragali, is the general designation of plant and Chinese crude drug.The traditional Chinese medical science is thought " the spleen being the foundation of acquired constitution ".Taste send representative figure Li Gao to think that the Radix Astragali " beneficial vigour and mend three warmers ", the yellow palace of the Qing Dynasty are embroidered to claim that the Radix Astragali is " all medicines of QI invigorating ".Modern study finds, the Radix Astragali can not only coronary artery dilator, improves blood supply of cardiac muscle, improves immunologic function, and process that can delaying cell aging.The medicinal history in existing more than 2000 year so far of the Radix Astragali, the Radix Astragali has invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, the effect of expelling pus and promoting granulation.It is weak to be used for the deficiency of vital energy, anorexia and loose stool, and sinking of QI of middle-JIAO, the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, carbuncle is difficult bursts, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst." herbal classic " record: " main carbuncle loses skin ulcer for a long time, the evacuation of pus pain relieving.Tonify deficiency, children's's all kinds of diseases and ailments." " Japan hanako materia medica " record: " help the gas strengthening bone and muscle, put on flesh and enrich blood ".Modern study, the Radix Astragali contain various trace elements such as Saponin, sucrose, glucuronic acid, polysaccharide, several amino acids, bitter principle, Radix Astragali saponin, choline, folic acid and selenium, silicon, zinc, cobalt, copper, molybdenum.It has enhancing human body immunity function, resisting fatigue, defying age, antiulcer, anti-stress, protect the liver, diuresis, blood pressure lowering and antibacterial action more widely, can eliminate experimental nephritic proteinuria, strengthens myocardial contraction, blood sugar regulation content.The Radix Astragali can not only coronary artery dilator, improves blood supply of cardiac muscle, improves immunologic function, and process that can delaying cell aging, can also be used to prevent the generation of some infectious disease.
Fructus Lycii is the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L., and its sweet in the mouth, property are put down, and have the effect of the liver and the kidney tonifying.Say " obey hard muscles and bones for a long time, it is not old to make light of one's life by commiting suicide, cold-resistant summer-heat " in the Compendium of Material Medica.The traditional Chinese medical science commonly used it treat hepatic and renal YIN deficiency, soreness of the waist and knees, dizziness, forgetful, dizzy, many tears of blurred vision, quench one's thirst, disease such as seminal emission.Shennong's Herbal claims Fructus Lycii " obey hard muscles and bones for a long time, it is not old to make light of one's life by commiting suicide, cold-resistant summer-heat "." book on Chinese herbal medicine converge with speech " praises it " gas can be filled, and blood can be mended, Yang Kesheng, the moon can be grown ".Fructus Lycii contains lycium barbarum polysaccharide, monosaccharide, betanin, carotene, zeaxanthine, fatty acid, protein and polypeptide, vitamin B
1, vitamin B
2, vitamin C, Sitosterolum, linoleic acid, 18 seed amino acids (containing 8 kinds of essential amino acids), trace element (calcium, zinc, magnesium, ferrum, manganese, phosphorus) etc.Fructus Lycii has similar Radix Ginseng " adaptation former state " effect, and can arteriosclerosis, effects such as blood sugar lowering, promotion hepatocyte new life, clothes health invigorating, the effect of slow down aging arranged.The effect of aspects such as modern pharmacology studies confirm that Fructus Lycii scalable body's immunity, can effectively suppress tumor growth and cell mutation, has slow down aging, anti-fatty liver, blood lipid regulation and blood glucose, promotion hemopoietic function, and be applied to clinical.
The present invention has adopted Testa Tritici polypeptide and Cordyceps, the Radix Astragali, Fructus Lycii, and these have and improve human body immunity, antioxidation, replenish aminoacid, improve the natural Chinese medicinal herb of effects such as cell viability; pulverize at low temperature, homogenizing are made Chinese drugs agentia; be rich in polypeptide, saponins, polysaccharide, vitamin and trace element etc.;, fatiguability low, weak and sickly mid-aged population to immunocompetence; has the significant protection body health, the antifatigue effect.
The specific embodiment
Embodiment 1 preparation Testa Tritici polypeptide
1) raw material: the Testa Tritici that is left after the wheat processing;
2) alkaline process extracts Testa Tritici albumen: Testa Tritici is pulverized with pulverizer, adds the proportioning of 15ml NaOH solution by every gram Testa Tritici, adds the NaOH solution of pH 11, and extracting temperature is 50 ℃, and the time is 2.5h, centrifugal collecting precipitation, and lyophilization prepares the Testa Tritici protein powder.
3) compound enzyme fractional hydrolysis: prepare Testa Tritici polypeptide with alkaline protease and compound protease fractional hydrolysis.Get the Testa Tritici protein powder, at first carry out enzymolysis with alkaline protease, enzymatic hydrolysis condition is: pH 8, and enzyme addition alive is the 6000u/g material, time 3h, 50 ℃ of temperature; Add compound protease then and carry out enzymolysis, enzymatic hydrolysis condition is: pH6, and enzyme addition alive is the 6000u/g material, time 1h, 55 ℃ of temperature; Enzymolysis solution behind the enzymolysis is heated to 100 ℃, keeps 10 minutes to kill the vigor of enzyme;
4) ultrafiltration: adopting molecular cut off is the enzymolysis solution of 10kDa ultrafiltration plate ultrafiltration step 3 preparations, and collecting molecular weight is the following enzymolysis solution of 10kDa;
5) lyophilization: the molecular weight that step 4 is obtained is that the enzymolysis solution below the 10kDa is freezing with low-temperature freeze-drying machine, and drying makes the Testa Tritici polypeptide powder.
Embodiment 2 contains the anti-fatigue Chinese medicine capsule of Testa Tritici polypeptide
Get the Testa Tritici polypeptide of embodiment 1 preparation
One, get the raw materials ready according to following prescription:
Testa Tritici polypeptide 7kg
Cordyceps 3kg
Radix Astragali 1kg
Fructus Lycii 1kg
Two, Cordyceps, the Radix Astragali, Fructus Lycii are pulverized with Lowtemperaturepulverizer, made powder;
Three, by said ratio, with the abundant homogenizing of Cordyceps, the Radix Astragali, Fructus Lycii and Testa Tritici polypeptide;
Four, the mixture behind the abundant homogenizing is made capsule through sterile filling.
Embodiment 3 contains the anti-fatigue Chinese medicine tablet of Testa Tritici polypeptide
Get the Testa Tritici polypeptide of embodiment 1 preparation
One, get the raw materials ready according to following prescription:
Testa Tritici polypeptide 9kg
Cordyceps 5kg
Radix Astragali 3kg
Fructus Lycii 3kg
Two, Cordyceps, the Radix Astragali, Fructus Lycii are pulverized with Lowtemperaturepulverizer, made powder;
Three, by said ratio, with the abundant homogenizing of Cordyceps, the Radix Astragali, Fructus Lycii and Testa Tritici polypeptide;
Four, with the mixture behind the abundant homogenizing routinely technology make tablet.
Embodiment 4 contains the anti-fatigue Chinese medicine electuary of Testa Tritici polypeptide
Get the Testa Tritici polypeptide of embodiment 1 preparation
One, get the raw materials ready according to following prescription:
Testa Tritici polypeptide 8kg
Cordyceps 4kg
Radix Astragali 2kg
Fructus Lycii 2kg
Two, Cordyceps, the Radix Astragali, Fructus Lycii are pulverized with Lowtemperaturepulverizer, made powder;
Three, by said ratio, with the abundant homogenizing of Cordyceps, the Radix Astragali, Fructus Lycii and Testa Tritici polypeptide;
Four, with the mixture behind the abundant homogenizing routinely technology make electuary.
Effect:
Experimental technique: the anti-fatigue Chinese medicine capsule that contains Testa Tritici polypeptide of getting embodiment 2 preparations.Select body weight 22 ± 2g Kunming mouse, after mice adaptation one week of raising, mice is divided into experimental group and matched group at random according to body weight, 10 every group, male and female half and half; Experimental group every Mus every day is irritated stomach Testa Tritici polypeptide capsule thing respectively once, and basic, normal, high dosage is respectively 50,100,200mg/kgd, and the matched group distilled water is irritated stomach, and irritating the stomach amount is 0.1mL/10g.Experiment periods is 30d, carries out the resisting fatigue index determining.
The Testa Tritici polypeptide capsule is to the influence of mice swimming with a load attached to the body time, serum urea nitrogen and hepatic glycogen
Annotate: compare with matched group,
aSignificant difference, P＜0.05,
bDifference is extremely remarkable, P＜0.01
By table as seen, compare with matched group, each dosage group of Testa Tritici polypeptide capsule obviously prolongs the swimming time of mice.Basic, normal, high dosage group has increased by 2.08,6.2 and 10.51min respectively than the mice swimming time of blank group, and middle and high dosage group is compared with matched group and is remarkable difference (p＜0.01).Illustrate that the Testa Tritici polypeptide capsule has the effect that has prolonged the mice swimming time to some extent, wherein with the best results of high dose group.The Testa Tritici polypeptide capsule shows the result that influences of Mouse Liver glycogen content: compare with matched group, behind the oral Testa Tritici polypeptide capsule of middle and high dosage group mice, Mouse Liver glycogen deposit is extremely significantly increases (p＜0.01), show that the Testa Tritici polypeptide capsule can increase animal subject hepatic glycogen deposit, for human body provides more multipotency source material, thereby delay fatigue produces.The Testa Tritici polypeptide capsule shows mice serum blood urea nitrogen result: compare with matched group, the blood urea nitrogen content concn of each dosage group of Testa Tritici polypeptide capsule all decreases, low dose group is compared with matched group and is remarkable difference (p＜0.05), middle and high dosage group is compared with matched group and is utmost point significant difference (p＜0.01), show that the Testa Tritici polypeptide capsule has the blood urea nitrogen content that produces in the removing mouse movement, reduce the effect of blood urea nitrogen content, it is best wherein to reduce effect with high dose group.
According to result of the test as seen, the anti-fatigue Chinese medicine that contains Testa Tritici polypeptide can improve animal subject exercise tolerance and the tired relevant physiological and biochemical index of good influence, thereby shows antifatigue effect, and has tangible dose-effect relationship.Therefore, the present invention has good antifatigue effect.
Claims (3)
1. anti-fatigue Chinese medicine that contains Testa Tritici polypeptide is characterized in that making medicament by weight ratio by following raw material:
Testa Tritici polypeptide 7-9 part,
Cordyceps 3-5 part,
Radix Astragali 1-3 part,
Fructus Lycii 1-3 part.
2. according to the described anti-fatigue Chinese medicine that contains Testa Tritici polypeptide of claim 1, it is characterized in that described medicament is tablet, pill, electuary or capsule.
3. claim 1 or the 2 described preparation methoies that contain the anti-fatigue Chinese medicine of Testa Tritici polypeptide is characterized in that comprising the steps:
1) preparation of Testa Tritici polypeptide: Testa Tritici is pulverized, added the proportioning of 10～20ml NaOH solution by every gram Testa Tritici, add the NaOH solution of pH 11, extracting temperature is 45～55 ℃, and the time is 2～3 hours, centrifugal collecting precipitation, and lyophilization makes the Testa Tritici protein powder; Get the Testa Tritici protein powder, add the alkaline protease enzymolysis, enzymatic hydrolysis condition is: pH 8, and enzyme addition alive is 6000u/g, 2.5～3.5 hours time, 50 ℃ of temperature; Add the compound protease enzymolysis then, enzymatic hydrolysis condition is: pH 6, and enzyme addition alive is 6000u/g, 1～1.5 hour time, 55 ℃ of temperature; Enzymolysis solution behind the enzymolysis is heated to 100 ℃, kept 10 minutes; Adopting molecular cut off is the ultrafiltration of 10kDa ultrafiltration plate, and collecting molecular weight is the following enzymolysis solution of 10kDa; Lyophilization makes Testa Tritici polypeptide;
2) Cordyceps, the Radix Astragali, Fructus Lycii are pulverized;
3) by the described proportioning of claim 1,, make tablet, pill, electuary or capsule with Testa Tritici polypeptide, Cordyceps, the Radix Astragali and Fructus Lycii mix homogeneously.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102860509A (en) * | 2012-10-09 | 2013-01-09 | 三普药业股份有限公司 | Anti-fatigue immunity-improving health food and preparation method thereof |
| CN102860510A (en) * | 2012-10-09 | 2013-01-09 | 三普药业股份有限公司 | Anti-fatigue anti-anoxia health food and preparation method thereof |
| CN103461643A (en) * | 2013-09-06 | 2013-12-25 | 江苏丘陵地区镇江农业科学研究所 | Method for extracting bran polypeptide and bran estrogen through wet ball milling in combination with enzymic method |
| CN105029448A (en) * | 2015-08-17 | 2015-11-11 | 安徽省华银茶油有限公司 | Chinese yam and medlar kidney nourishing and body strengthening tea seed polypeptide lozenge and preparing method of lozenge |
| CN105341618A (en) * | 2015-10-01 | 2016-02-24 | 常州市奥普泰科光电有限公司 | Preparation method of antioxidant for vegetable protein foods |
| CN106473138A (en) * | 2016-09-26 | 2017-03-08 | 天津保元堂生物科技有限公司 | Donkey-hide gelatin ginseng protein powder and preparation method thereof |
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| CN101513257A (en) * | 2009-03-10 | 2009-08-26 | 黄继红 | Method for fermenting functional wheat bran |
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| CN1875737A (en) * | 2006-06-30 | 2006-12-13 | 北京工商大学 | An oat peptide and extraction method thereof |
| CN101513257A (en) * | 2009-03-10 | 2009-08-26 | 黄继红 | Method for fermenting functional wheat bran |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102860509A (en) * | 2012-10-09 | 2013-01-09 | 三普药业股份有限公司 | Anti-fatigue immunity-improving health food and preparation method thereof |
| CN102860510A (en) * | 2012-10-09 | 2013-01-09 | 三普药业股份有限公司 | Anti-fatigue anti-anoxia health food and preparation method thereof |
| CN103461643A (en) * | 2013-09-06 | 2013-12-25 | 江苏丘陵地区镇江农业科学研究所 | Method for extracting bran polypeptide and bran estrogen through wet ball milling in combination with enzymic method |
| CN105029448A (en) * | 2015-08-17 | 2015-11-11 | 安徽省华银茶油有限公司 | Chinese yam and medlar kidney nourishing and body strengthening tea seed polypeptide lozenge and preparing method of lozenge |
| CN105341618A (en) * | 2015-10-01 | 2016-02-24 | 常州市奥普泰科光电有限公司 | Preparation method of antioxidant for vegetable protein foods |
| CN106473138A (en) * | 2016-09-26 | 2017-03-08 | 天津保元堂生物科技有限公司 | Donkey-hide gelatin ginseng protein powder and preparation method thereof |
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| CN101884783B (en) | 2013-03-06 |
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