CN101791351B - Glipizide-containing traditional Chinese and western medicine composition - Google Patents
Glipizide-containing traditional Chinese and western medicine composition Download PDFInfo
- Publication number
- CN101791351B CN101791351B CN201010150935XA CN201010150935A CN101791351B CN 101791351 B CN101791351 B CN 101791351B CN 201010150935X A CN201010150935X A CN 201010150935XA CN 201010150935 A CN201010150935 A CN 201010150935A CN 101791351 B CN101791351 B CN 101791351B
- Authority
- CN
- China
- Prior art keywords
- parts
- glipizide
- diabetes
- traditional chinese
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003814 drug Substances 0.000 title claims abstract description 27
- 239000000203 mixture Substances 0.000 title claims abstract description 18
- ZJJXGWJIGJFDTL-UHFFFAOYSA-N glipizide Chemical compound C1=NC(C)=CN=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZJJXGWJIGJFDTL-UHFFFAOYSA-N 0.000 title claims abstract description 13
- 229960001381 glipizide Drugs 0.000 title claims abstract description 10
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract description 15
- 238000002360 preparation method Methods 0.000 claims description 4
- 235000016993 Agrimonia Nutrition 0.000 claims description 2
- 241000545442 Radix Species 0.000 claims description 2
- 241001530126 Scrophularia Species 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 241001092084 Agrimonia Species 0.000 claims 1
- 229940079593 drug Drugs 0.000 abstract description 7
- 230000002195 synergetic effect Effects 0.000 abstract 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 8
- 230000000694 effects Effects 0.000 description 6
- 102000004877 Insulin Human genes 0.000 description 4
- 108090001061 Insulin Proteins 0.000 description 4
- 230000037396 body weight Effects 0.000 description 4
- 230000002218 hypoglycaemic effect Effects 0.000 description 4
- 229940125396 insulin Drugs 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 229940123208 Biguanide Drugs 0.000 description 3
- 239000003390 Chinese drug Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 208000024172 Cardiovascular disease Diseases 0.000 description 2
- 208000013016 Hypoglycemia Diseases 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 229940127003 anti-diabetic drug Drugs 0.000 description 2
- 239000003472 antidiabetic agent Substances 0.000 description 2
- 150000004283 biguanides Chemical class 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 230000003285 pharmacodynamic effect Effects 0.000 description 2
- WVAKABMNNSMCDK-UHFFFAOYSA-N sulfacarbamide Chemical compound NC(=O)NS(=O)(=O)C1=CC=C(N)C=C1 WVAKABMNNSMCDK-UHFFFAOYSA-N 0.000 description 2
- 229950010053 sulfacarbamide Drugs 0.000 description 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 2
- 201000010000 Agranulocytosis Diseases 0.000 description 1
- 244000307697 Agrimonia eupatoria Species 0.000 description 1
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- 206010018687 Granulocytopenia Diseases 0.000 description 1
- 206010020660 Hyperlactacidaemia Diseases 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 208000022329 Protein metabolism disease Diseases 0.000 description 1
- 244000179560 Prunella vulgaris Species 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 229940100389 Sulfonylurea Drugs 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000003178 anti-diabetic effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 230000002079 cooperative effect Effects 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 210000003677 hemocyte Anatomy 0.000 description 1
- 229940000351 hemocyte Drugs 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 208000006443 lactic acidosis Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 206010062198 microangiopathy Diseases 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a synergistic medicine composition containing glipizide and traditional Chinese medicine extractives and application thereof in preparing medicines for treating diabetes.
Description
Technical field
The present invention relates to a kind of Chinese and western medicinal composition for the treatment of diabetes, specifically contain the compositions of glipizide and Chinese medicine extract, and the purposes of said composition in preparation treatment type ii diabetes medicine.
Background technology
Diabetes are one of several big diseases of serious harm human health in the world, and present treatment medicine is all undesirable.For example, sulfaurea drugs and biguanide drug, curative effect is low, and side effect is big, and with producing hyperlactacidemia, the caused mortality that has hypoglycemia, sulfaurea drugs are for a long time with infringement liver, kidney and hemocyte for a long time.Insulin with producing antibody, increases dosage for a long time, easily impels microvascular disease.Though the Chinese patent medicine of treatment diabetes is also arranged at present, and effect is all not fairly obvious.Diabetes do not heal all the life, and complication extensively and seriously because insulin lacks relatively or definitely in the blood, causes sugar, fat, protein metabolism disorder, causes hyperglycemia, the rising of hyperlipidemia and blood viscosity, and the middle and advanced stage appearance whole body is microangiopathies extensively.Wherein 70%-80% patient dies from cardiovascular disease, diabetes kidney function failure; Cerebrovascular accident is the common cause of death of middle and elderly diabetic patient.
Mostly the medicine of clinical treatment II type is chemicals except that insulin, widely used sulphanylureas, biguanides, other antidiabetic drugs and the adjuvant drug of being broadly divided into.The sulfonylureas drugs for diabetes thing is topmost Remedies for diabetes.Can make that hepatic glycogen is synthetic to be increased,, surrounding tissue be strengthened to the sensitivity of insulin, the picked-up of glucose is increased, thereby reach the effect of blood sugar lowering again by the effect behind pair cell receptor or the receptor.But more easily cause untoward reaction such as hypoglycemia, granulocytopenia and cardiovascular disease.Biguanides antidiabetic drug heavy dose can cause digestive tract reaction, has the patient of pathological changes easily to cause lactic acidosis at lung, liver, kidney.Bring hidden danger for the extensive patients drug safety, for a change this situation for a long time, attempts treating with protocol in the plant clinically always.The traditional Chinese medical science is consistent to the cause of disease view of diabetes, thinks it mainly is that surfeit delicious food, overaction of the five emotions, chamber do not save, the dry and not enough Several Factors of natural endowment of calentura fire.But Chinese medicine also comes with some shortcomings, and is slow as onset, need having the experience old docter of TCM to identify and correct use etc. under instructing.The present invention attempts Chinese medicine and Western medicine are combined, and with the problem of avoiding existing separately, and improves the treatment of diabetes effect, promptly produces synergism.
Summary of the invention
One object of the present invention is to provide the Pharmaceutical composition of being made up of glipizide and a kind of Chinese medicine extract, wherein the Chinese medicine extract of said composition is according to following formulation, as follows: by weight with 10 parts of Radix Rehmanniae, 10 parts of Radix Polygoni Multiflori, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of the Radixs Astragali, 8 parts of Radix Scrophulariaes, 10 parts of Herba Agrimoniaes, 8 parts on Folium Mori, decoct with water, filter, be concentrated into thick paste, drying.
One object of the present invention is to provide the purposes of above-mentioned Pharmaceutical composition in the medicine of preparation treatment diabetes.
This Chinese medical concrete is called " the described Chinese medicine extract of this paper (or above) " hereinafter.
Above-mentioned composition and mixing acceptable accessories can be made acceptable forms clinically, as tablet, capsule, granule, oral liquid, subcutaneous administration preparation, suppository etc.
Pharmacological research
The main pharmacodynamics of Pharmaceutical composition of the present invention studies confirm that it has strong antidiabetic effect, i.e. hypoglycemic activity.
Edit with reference to Zhang Juntian, " modern pharmacology test method " (first volume), Beijing combined publication society of medical science China Concord Medical Science University, the 984-985 page or leaf, disclosed method in " animal model of the similar type ii diabetes of second joint ", set up experimental obesity and diabetes rat model, carry out the hypoglycemic pharmacodynamics test of Pharmaceutical composition of the present invention.
The test grouping:
1 model control group: after the animal model modeling success, normal physiological saline is irritated stomach;
2 pure Chinese drug-treated group: extractum 1.04g/kg body weight as indicated above is irritated stomach
3 glipizide groups: the 10mg/kg body weight is irritated stomach
4 compositions groups: 10mg/kg body weight glipizide+extractum 1.04g/kg body weight mentioned above is irritated stomach.
This table shows that all there is significant difference in each group (pure Chinese drug-treated group, glipizide group, compositions group) of treatment with model control group, and all there are significant difference in compositions group and pure Chinese drug-treated group, compositions group and glipizide group.Show that there are cooperative effect in glipizide and described Chinese medicinal components in the compositions group.
The pharmaceutics test
Wherein compositions is made up of with weight ratio glipizide and described Chinese medicine extract at 1: 104.
Can produce the capsule that contains following component in a conventional manner:
Wherein compositions is made up of with weight ratio glipizide and described Chinese medicine extract at 1: 104.
Claims (2)
1. a compositions for the treatment of diabetes is characterized in that being made up of at 1: 104 with weight ratio glipizide and Chinese medicine extract, and wherein this Chinese medicine extract is made according to following method:
With 10 parts of Radix Rehmanniae, 10 parts of Radix Polygoni Multiflori, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of the Radixs Astragali, 8 parts of Radix Scrophulariaes, 10 parts of Herba Agrimoniaes, 8 parts on Folium Mori, decoct with water by weight, filter, be concentrated into thick paste, drying.
2. the purposes of compositions as claimed in claim 1 in the medicine of preparation treatment diabetes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010150935XA CN101791351B (en) | 2010-04-20 | 2010-04-20 | Glipizide-containing traditional Chinese and western medicine composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010150935XA CN101791351B (en) | 2010-04-20 | 2010-04-20 | Glipizide-containing traditional Chinese and western medicine composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101791351A CN101791351A (en) | 2010-08-04 |
| CN101791351B true CN101791351B (en) | 2011-11-30 |
Family
ID=42584411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201010150935XA Expired - Fee Related CN101791351B (en) | 2010-04-20 | 2010-04-20 | Glipizide-containing traditional Chinese and western medicine composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101791351B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105616581A (en) * | 2016-03-27 | 2016-06-01 | 济南邦文医药科技有限公司 | Glipizide-containing pharmaceutical composition for treating diabetes and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1872138A (en) * | 2006-04-24 | 2006-12-06 | 北京国丹药物技术开发有限公司 | Medicinal composition for use in treating diabetes, and preparation method |
-
2010
- 2010-04-20 CN CN201010150935XA patent/CN101791351B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1872138A (en) * | 2006-04-24 | 2006-12-06 | 北京国丹药物技术开发有限公司 | Medicinal composition for use in treating diabetes, and preparation method |
Non-Patent Citations (2)
| Title |
|---|
| 姜生坤，马新和，等.ⅠⅠ型糖尿病从肝论治探讨.《陕西中医》.2002,第23卷(第5 期),428－430. * |
| 庄国芳1.中西医结合治疗2 型糖尿病49 例临床观察.《西南国防医药》.2004,第14卷(第6期),636-637. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101791351A (en) | 2010-08-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102526478A (en) | Formula of health-care medicine with functions of strengthening immunity and reducing blood sugar | |
| CN102526479A (en) | Health-care medicine formula with functions of enhancing immunity and lowering blood sugar | |
| CN101856405B (en) | Medicinal composition for treating type II diabetes mellitus and preparation method thereof | |
| CN104815166B (en) | A kind of Chinese medicine composition for treating diabetes and its preparation and application | |
| CN105287812A (en) | Medicine composition for treating irritable bowel syndromes and application of medicine composition | |
| CN102861201A (en) | Medicine composition for treating diabetes and preparation method thereof | |
| CN104083640A (en) | Traditional Chinese medicinal composition for treating diabetes mellitus and preparation method thereof | |
| CN101264203B (en) | Chinese and western medicine composition for treating diabetes | |
| CN102266391A (en) | Composition extracted from medicinal and edible plants and able to adjust fasting and postprandial blood glucose simultaneously | |
| CN101791351B (en) | Glipizide-containing traditional Chinese and western medicine composition | |
| CN101791350B (en) | Glibenclamide-containing traditional Chinese and western medicine composition | |
| CN101757253B (en) | Traditional Chinese medicine and Western medicine composition containing gliquidone | |
| CN102018852A (en) | Ginseng and coptis capsule for quenching thirsty and reducing blood sugar and preparation process | |
| CN101773572B (en) | Chinese-western medicine composition containing nateglinide | |
| CN101791352B (en) | Phenformin-containing traditional Chinese and western medicine composition | |
| CN103566227B (en) | A kind of Chinese medicine composition preventing and treating type 2 diabetes mellitus and preparation method thereof | |
| CN103181945B (en) | The purposes of Semen Luffae | |
| CN101406576B (en) | Chinese medicine for treating diabetes and preparation method | |
| CN104983759A (en) | Traditional Chinese medicine composition treating diabetic nephropathy and preparing method thereof | |
| CN1327879C (en) | Medicine for treating diabetes and its preparing method | |
| CN100363000C (en) | Chinese and western medicines composition contg. Avandia and its prepn. method | |
| CN105343506A (en) | Method for preparing composition for treating type-2 diabetes | |
| CN103989940A (en) | Traditional Chinese medicine composition for treating diabetes mellitus | |
| CN104027450B (en) | A kind of Chinese medicine composition for the treatment of diabetes | |
| CN100362988C (en) | Chinese and western medicine composition contg. metformin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: HU KEDING Effective date: 20121120 Owner name: NANTONG HUAKE INTELLECTUAL PROPERTY SERVICE CO., L Free format text: FORMER OWNER: HU KEDING Effective date: 20121120 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 315318 NINGBO, ZHEJIANG PROVINCE TO: 226600 NANTONG, JIANGSU PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20121120 Address after: 226600 No. 8 Yingbin Road, East Town, Haian County, Nantong, Jiangsu Patentee after: Nantong Huake Intellectual Property Service Co.,Ltd. Patentee after: Hu Keding Address before: 315318 Wu Meicun, Henghe Town, Cixi, Zhejiang Patentee before: Hu Keding |
|
| ASS | Succession or assignment of patent right |
Free format text: FORMER OWNER: HU KEDING Effective date: 20130219 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 226600 NANTONG, JIANGSU PROVINCE TO: 226000 NANTONG, JIANGSU PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20130219 Address after: 226000 No. 8 Yingbin Road, Haian County, Jiangsu, Nantong Patentee after: Nantong Huake Intellectual Property Service Co.,Ltd. Address before: 226600 No. 8 Yingbin Road, East Town, Haian County, Nantong, Jiangsu Patentee before: Nantong Huake Intellectual Property Service Co.,Ltd. Patentee before: Hu Keding |
|
| ASS | Succession or assignment of patent right |
Owner name: HAIAN CHANGDA TECHNOLOGY TRANSFER CENTER CO., LTD. Free format text: FORMER OWNER: NANTONG HUAKE INTELLECTUAL PROPERTY SERVICE CO., LTD. Effective date: 20131213 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 226000 NANTONG, JIANGSU PROVINCE TO: 226601 NANTONG, JIANGSU PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20131213 Address after: 226601 No. 8 Yingbin Road, Haian County, Nantong, Jiangsu Patentee after: HAIAN CHANGZHOU UNIVERSITY TECHNOLOGY TRANSFER CENTER Co.,Ltd. Address before: 226000 No. 8 Yingbin Road, Haian County, Jiangsu, Nantong Patentee before: Nantong Huake Intellectual Property Service Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20221227 Address after: 413, Floor 4, Building B, Innovation Building, Linyi Hi tech Industrial Development Zone, Shandong Province, 276000 Patentee after: Linyi High tech Zone Jinlanling Labor Service Co.,Ltd. Address before: No.8 Yingbin Road, Hai'an County, Nantong City, Jiangsu Province Patentee before: HAIAN CHANGZHOU UNIVERSITY TECHNOLOGY TRANSFER CENTER Co.,Ltd. |
|
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20111130 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |