CN101791350B - Glibenclamide-containing traditional Chinese and western medicine composition - Google Patents
Glibenclamide-containing traditional Chinese and western medicine composition Download PDFInfo
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- CN101791350B CN101791350B CN2010101509326A CN201010150932A CN101791350B CN 101791350 B CN101791350 B CN 101791350B CN 2010101509326 A CN2010101509326 A CN 2010101509326A CN 201010150932 A CN201010150932 A CN 201010150932A CN 101791350 B CN101791350 B CN 101791350B
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- glibenclamide
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- 239000003814 drug Substances 0.000 title claims abstract description 27
- 239000000203 mixture Substances 0.000 title claims abstract description 18
- ZNNLBTZKUZBEKO-UHFFFAOYSA-N glyburide Chemical compound COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZNNLBTZKUZBEKO-UHFFFAOYSA-N 0.000 title claims abstract description 13
- 229960004580 glibenclamide Drugs 0.000 title claims abstract description 10
- 241000545442 Radix Species 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 4
- 235000016993 Agrimonia Nutrition 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 241001092084 Agrimonia Species 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract description 13
- 229940079593 drug Drugs 0.000 abstract description 7
- 230000002195 synergetic effect Effects 0.000 abstract 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 8
- 230000000694 effects Effects 0.000 description 6
- 102000004877 Insulin Human genes 0.000 description 4
- 108090001061 Insulin Proteins 0.000 description 4
- 230000037396 body weight Effects 0.000 description 4
- 230000002218 hypoglycaemic effect Effects 0.000 description 4
- 229940125396 insulin Drugs 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 229940123208 Biguanide Drugs 0.000 description 3
- 239000003390 Chinese drug Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 208000024172 Cardiovascular disease Diseases 0.000 description 2
- 208000013016 Hypoglycemia Diseases 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 229940127003 anti-diabetic drug Drugs 0.000 description 2
- 239000003472 antidiabetic agent Substances 0.000 description 2
- 150000004283 biguanides Chemical class 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 230000003285 pharmacodynamic effect Effects 0.000 description 2
- WVAKABMNNSMCDK-UHFFFAOYSA-N sulfacarbamide Chemical compound NC(=O)NS(=O)(=O)C1=CC=C(N)C=C1 WVAKABMNNSMCDK-UHFFFAOYSA-N 0.000 description 2
- 229950010053 sulfacarbamide Drugs 0.000 description 2
- 201000010000 Agranulocytosis Diseases 0.000 description 1
- 244000307697 Agrimonia eupatoria Species 0.000 description 1
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- 206010018687 Granulocytopenia Diseases 0.000 description 1
- 206010020660 Hyperlactacidaemia Diseases 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 208000022329 Protein metabolism disease Diseases 0.000 description 1
- 244000179560 Prunella vulgaris Species 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 229940100389 Sulfonylurea Drugs 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000003178 anti-diabetic effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 230000002079 cooperative effect Effects 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 210000003677 hemocyte Anatomy 0.000 description 1
- 229940000351 hemocyte Drugs 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 208000006443 lactic acidosis Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 206010062198 microangiopathy Diseases 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a synergistic medicine composition containing glibenclamide and traditional Chinese medicine extractives and application thereof in preparing medicines for treating diabetes.
Description
Technical field
The present invention relates to a kind of Chinese and western medicinal composition for the treatment of diabetes, specifically contain the compositions of glibenclamide and Chinese medicine extract, and the purposes of said composition in preparation treatment type ii diabetes medicine.
Background technology
Diabetes are one of several big diseases of serious harm human health in the world, and present treatment medicine is all undesirable.For example, sulfaurea drugs and biguanide drug, curative effect is low, and side effect is big, and with producing hyperlactacidemia, the caused mortality that has hypoglycemia, sulfaurea drugs are for a long time with infringement liver, kidney and hemocyte for a long time.Insulin with producing antibody, increases dosage for a long time, easily impels microvascular disease.Though the Chinese patent medicine of treatment diabetes is also arranged at present, and effect is all not fairly obvious.Diabetes do not heal all the life, and complication extensively and seriously because insulin lacks relatively or definitely in the blood, causes sugar, fat, protein metabolism disorder, causes hyperglycemia, the rising of hyperlipidemia and blood viscosity, and the middle and advanced stage appearance whole body is microangiopathies extensively.Wherein 70%-80% patient dies from cardiovascular disease, diabetes kidney function failure; Cerebrovascular accident is the common cause of death of middle and elderly diabetic patient.
Mostly the medicine of clinical treatment II type is chemicals except that insulin, widely used sulphanylureas, biguanides, other antidiabetic drugs and the adjuvant drug of being broadly divided into.The sulfonylureas drugs for diabetes thing is topmost Remedies for diabetes.Can make that hepatic glycogen is synthetic to be increased,, surrounding tissue be strengthened to the sensitivity of insulin, the picked-up of glucose is increased, thereby reach the effect of blood sugar lowering again by the effect behind pair cell receptor or the receptor.But more easily cause untoward reaction such as hypoglycemia, granulocytopenia and cardiovascular disease.Biguanides antidiabetic drug heavy dose can cause digestive tract reaction, has the patient of pathological changes easily to cause lactic acidosis at lung, liver, kidney.Bring hidden danger for the extensive patients drug safety, for a change this situation for a long time, attempts treating with protocol in the plant clinically always.The traditional Chinese medical science is consistent to the cause of disease view of diabetes, thinks it mainly is that surfeit delicious food, overaction of the five emotions, chamber do not save, the dry and not enough Several Factors of natural endowment of calentura fire.But Chinese medicine also comes with some shortcomings, and is slow as onset, need having the experience old docter of TCM to identify and correct use etc. under instructing.The present invention attempts Chinese medicine and Western medicine are combined, and with the problem of avoiding existing separately, and improves the treatment of diabetes effect, promptly produces synergism.
Summary of the invention
One object of the present invention is to provide the Pharmaceutical composition of being made up of glibenclamide and a kind of Chinese medicine extract, wherein the Chinese medicine extract of said composition is according to following formulation, as follows: by weight with 10 parts in the Radix Rehmanniae, 10 parts of the Radixs Polygoni Multiflori, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of the Radixs Astragali, 8 parts of Radix Scrophulariae, 10 parts of Herba Agrimoniaes, 8 parts on Folium Mori, decoct with water, filter, be concentrated into thick paste, drying.
One object of the present invention is to provide the purposes of above-mentioned Pharmaceutical composition in the medicine of preparation treatment diabetes.
This Chinese medical concrete is called " the described Chinese medicine extract of this paper (or above) " hereinafter.
Above-mentioned composition and mixing acceptable accessories can be made acceptable forms clinically, as tablet, capsule, granule, oral liquid, subcutaneous administration preparation, suppository etc.
Pharmacological research
The main pharmacodynamics of Pharmaceutical composition of the present invention studies confirm that it has strong antidiabetic effect, i.e. hypoglycemic activity.
Edit with reference to Zhang Juntian, " modern pharmacology test method " (first volume), Beijing combined publication society of medical science China Concord Medical Science University, the 984-985 page or leaf, disclosed method in " animal model of the similar type ii diabetes of second joint ", set up experimental obesity and diabetes rat model, carry out the hypoglycemic pharmacodynamics test of Pharmaceutical composition of the present invention.
The test grouping:
1 model control group: after the animal model modeling success, normal physiological saline is irritated stomach;
2 pure Chinese drug-treated group: extractum 1.50g/kg body weight as indicated above is irritated stomach
3 glibenclamide groups: the 10mg/kg body weight is irritated stomach
4 compositions groups: 10mg/kg body weight glibenclamide+extractum 1.50g/kg body weight mentioned above is irritated stomach.
This table shows that all there is significant difference in each group (pure Chinese drug-treated group, glibenclamide group, compositions group) of treatment with model control group, and all there are significant difference in compositions group and pure Chinese drug-treated group, compositions group and glibenclamide group.Show that there are cooperative effect in glibenclamide and described Chinese medicinal components in the compositions group.
The pharmaceutics test
Wherein compositions is made up of with weight ratio glibenclamide and described Chinese medicine extract at 1: 150.
Can produce the capsule that contains following component in a conventional manner:
Wherein compositions is made up of with weight ratio glibenclamide and described Chinese medicine extract at 1: 150.
Claims (2)
1. a compositions for the treatment of type ii diabetes is characterized in that being made up of at 1: 150 with weight ratio glibenclamide and Chinese medicine extract, and wherein this Chinese medicine extract is made according to following method:
With 10 parts in the Radix Rehmanniae, 10 parts of the Radixs Polygoni Multiflori, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of the Radixs Astragali, 8 parts of Radix Scrophulariae, 10 parts of Herba Agrimoniaes, 8 parts on Folium Mori, decoct with water by weight, filter, be concentrated into thick paste, drying.
2. the purposes of compositions as claimed in claim 1 in the medicine of preparation treatment type ii diabetes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101509326A CN101791350B (en) | 2010-04-20 | 2010-04-20 | Glibenclamide-containing traditional Chinese and western medicine composition |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101509326A CN101791350B (en) | 2010-04-20 | 2010-04-20 | Glibenclamide-containing traditional Chinese and western medicine composition |
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| Publication Number | Publication Date |
|---|---|
| CN101791350A CN101791350A (en) | 2010-08-04 |
| CN101791350B true CN101791350B (en) | 2011-06-29 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010101509326A Expired - Fee Related CN101791350B (en) | 2010-04-20 | 2010-04-20 | Glibenclamide-containing traditional Chinese and western medicine composition |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105687599A (en) * | 2016-03-27 | 2016-06-22 | 济南邦文医药科技有限公司 | Glibenclamide containing pharmaceutical composition for treating diabetes and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1077642A (en) * | 1993-02-18 | 1993-10-27 | 广东省石龙华南制药厂 | The Chinese prescription of treatment diabetes, preparation and preparation method thereof |
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| Publication number | Publication date |
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Owner name: HAIAN CHANGDA TECHNOLOGY TRANSFER CENTER CO., LTD. Free format text: FORMER OWNER: NANTONG HUAKE INTELLECTUAL PROPERTY SERVICE CO., LTD. Effective date: 20131213 |
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