CN101791350B - Glibenclamide-containing traditional Chinese and western medicine composition - Google Patents
Glibenclamide-containing traditional Chinese and western medicine composition Download PDFInfo
- Publication number
- CN101791350B CN101791350B CN2010101509326A CN201010150932A CN101791350B CN 101791350 B CN101791350 B CN 101791350B CN 2010101509326 A CN2010101509326 A CN 2010101509326A CN 201010150932 A CN201010150932 A CN 201010150932A CN 101791350 B CN101791350 B CN 101791350B
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- China
- Prior art keywords
- parts
- glibenclamide
- diabetes
- traditional chinese
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003814 drug Substances 0.000 title claims abstract description 27
- 239000000203 mixture Substances 0.000 title claims abstract description 18
- ZNNLBTZKUZBEKO-UHFFFAOYSA-N glyburide Chemical compound COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZNNLBTZKUZBEKO-UHFFFAOYSA-N 0.000 title claims abstract description 13
- 229960004580 glibenclamide Drugs 0.000 title claims abstract description 10
- 241000545442 Radix Species 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 4
- 235000016993 Agrimonia Nutrition 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 241001092084 Agrimonia Species 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract description 13
- 229940079593 drug Drugs 0.000 abstract description 7
- 230000002195 synergetic effect Effects 0.000 abstract 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 8
- 230000000694 effects Effects 0.000 description 6
- 102000004877 Insulin Human genes 0.000 description 4
- 108090001061 Insulin Proteins 0.000 description 4
- 230000037396 body weight Effects 0.000 description 4
- 230000002218 hypoglycaemic effect Effects 0.000 description 4
- 229940125396 insulin Drugs 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 229940123208 Biguanide Drugs 0.000 description 3
- 239000003390 Chinese drug Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 208000024172 Cardiovascular disease Diseases 0.000 description 2
- 208000013016 Hypoglycemia Diseases 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 229940127003 anti-diabetic drug Drugs 0.000 description 2
- 239000003472 antidiabetic agent Substances 0.000 description 2
- 150000004283 biguanides Chemical class 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 230000003285 pharmacodynamic effect Effects 0.000 description 2
- WVAKABMNNSMCDK-UHFFFAOYSA-N sulfacarbamide Chemical compound NC(=O)NS(=O)(=O)C1=CC=C(N)C=C1 WVAKABMNNSMCDK-UHFFFAOYSA-N 0.000 description 2
- 229950010053 sulfacarbamide Drugs 0.000 description 2
- 201000010000 Agranulocytosis Diseases 0.000 description 1
- 244000307697 Agrimonia eupatoria Species 0.000 description 1
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- 206010018687 Granulocytopenia Diseases 0.000 description 1
- 206010020660 Hyperlactacidaemia Diseases 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 208000022329 Protein metabolism disease Diseases 0.000 description 1
- 244000179560 Prunella vulgaris Species 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 229940100389 Sulfonylurea Drugs 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000003178 anti-diabetic effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 230000002079 cooperative effect Effects 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 210000003677 hemocyte Anatomy 0.000 description 1
- 229940000351 hemocyte Drugs 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 208000006443 lactic acidosis Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 206010062198 microangiopathy Diseases 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2010101509326A CN101791350B (en) | 2010-04-20 | 2010-04-20 | Glibenclamide-containing traditional Chinese and western medicine composition |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2010101509326A CN101791350B (en) | 2010-04-20 | 2010-04-20 | Glibenclamide-containing traditional Chinese and western medicine composition |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101791350A CN101791350A (en) | 2010-08-04 |
CN101791350B true CN101791350B (en) | 2011-06-29 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN2010101509326A Expired - Fee Related CN101791350B (en) | 2010-04-20 | 2010-04-20 | Glibenclamide-containing traditional Chinese and western medicine composition |
Country Status (1)
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CN (1) | CN101791350B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105687599A (en) * | 2016-03-27 | 2016-06-22 | 济南邦文医药科技有限公司 | Glibenclamide containing pharmaceutical composition for treating diabetes and preparation method thereof |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1077642A (en) * | 1993-02-18 | 1993-10-27 | 广东省石龙华南制药厂 | The Chinese prescription of treatment diabetes, preparation and preparation method thereof |
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2010
- 2010-04-20 CN CN2010101509326A patent/CN101791350B/en not_active Expired - Fee Related
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CN101791350A (en) | 2010-08-04 |
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Owner name: HU KEDING Effective date: 20121120 Owner name: NANTONG HUAKE INTELLECTUAL PROPERTY SERVICE CO., L Free format text: FORMER OWNER: HU KEDING Effective date: 20121120 |
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Effective date of registration: 20121120 Address after: 226600 No. 8 Yingbin Road, East Town, Haian County, Nantong, Jiangsu Patentee after: Nantong Huake Intellectual Property Service Co.,Ltd. Patentee after: Hu Keding Address before: 315318 Wu Meicun, Henghe Town, Cixi, Zhejiang Patentee before: Hu Keding |
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Effective date of registration: 20130219 Address after: 226000 No. 8 Yingbin Road, Haian County, Jiangsu, Nantong Patentee after: Nantong Huake Intellectual Property Service Co.,Ltd. Address before: 226600 No. 8 Yingbin Road, East Town, Haian County, Nantong, Jiangsu Patentee before: Nantong Huake Intellectual Property Service Co.,Ltd. Patentee before: Hu Keding |
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Owner name: HAIAN CHANGDA TECHNOLOGY TRANSFER CENTER CO., LTD. Free format text: FORMER OWNER: NANTONG HUAKE INTELLECTUAL PROPERTY SERVICE CO., LTD. Effective date: 20131213 |
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Effective date of registration: 20131213 Address after: 226601 No. 8 Yingbin Road, Haian County, Nantong, Jiangsu Patentee after: HAIAN CHANGZHOU UNIVERSITY TECHNOLOGY TRANSFER CENTER Co.,Ltd. Address before: 226000 No. 8 Yingbin Road, Haian County, Jiangsu, Nantong Patentee before: Nantong Huake Intellectual Property Service Co.,Ltd. |
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Effective date of registration: 20221227 Address after: 413, Floor 4, Building B, Innovation Building, Linyi Hi tech Industrial Development Zone, Shandong Province, 276000 Patentee after: Linyi High tech Zone Jinlanling Labor Service Co.,Ltd. Address before: No.8 Yingbin Road, Hai'an County, Nantong City, Jiangsu Province Patentee before: HAIAN CHANGZHOU UNIVERSITY TECHNOLOGY TRANSFER CENTER Co.,Ltd. |
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