CN101869612A - Maxingshigan oral liquid and preparation method thereof - Google Patents

Abstract

The invention discloses maxingshigan oral liquid and a preparation method thereof. The preparation method comprises the following steps: taking 1000-2000 parts of gypsum and crushing into coarse powder; packing with gauze; decocting twice with 200-400 parts of ephedra, 200-400 parts of bitter apricot seed, 200-400 parts of liquorice, and 3000-6000 parts of water; merging the decocted liquid, filtering, concentrating the filter liquor to 500-1000 parts into dense paste, adding 200-400 parts of sucrose, 2-4 parts of benzoic acid, and 2-4 parts of ethylparaben, stirring, stewing, filtering to obtain 1000ml, and bulking to obtain the finished oral liquid. The preparation technology in the invention has simple control, high bioavailability, good and rapid curative effect and low cost.

Description

Maxingshigan oral liquid and preparation method thereof

Technical field

The present invention relates to the antitussive and anti-asthmatic medicine field, be specially Maxingshigan oral liquid that is used for the treatment of the poultry cough with asthma and preparation method thereof.

Background technology

The relieving cough and relieving asthma oral liquid is to attack lung by wind heat, or the wind and cold heat-transformation, stops up and to hold back due to the lung, and wind heat is stopped up lung, impairment of dispersing and descending function of the lung, so cough is breathed heavily, heat is stopped up and do not understood, and consumption impairment of body fluid liquid is so fever of the body is gradually even yearningly.Lung is stopped up QI rising in reverse order, and folding mistake department is so there is antiperspirant or lossless.Control when lung qi dispersing drinking agent heresy clear pathogen, eliminating heat from the lung.The traditional Chinese medical science and herbal medicine be to above-mentioned disease, and it is more to treat effective prescription.This prescription is one of more representational effective prescription that testing sieve is selected on extensive clinical its plinth, and through special process system drinking agent, makes its traceization, high efficiency, has improved curative effect and has reduced consumption.The prescription collocation rationally can make the laboratory animal vascular permeability reduce as effective ingredient ephedrine, the D-pseudoephedrine of Herba Ephedrae, and is antiinflammatory action, and this also helps analgesic.It is about more than 3% that Semen Armeniacae Amarum contains amygdalin, produces hydrocyanic acid and benzene first cooperation aldehyde, emulsin, fatty wet goods after the hydrolysis.Semen Armeniacae Amarum can promote the synthetic of pulmonary surfactant the intact animal, not only can promote the synthetic of pulmonary surfactant in oleic acid-induced RDS laboratory animal, and pathological changes is improved: the amygdalin in the Semen Armeniacae Amarum slowly decomposes in vivo, produce micro-hydrocyanic acid gradually, take in a small amount and can play slight inhibition respiratory center, thereby reach the effect of antitussive and antiasthmatic, so Semen Armeniacae Amarum is obvious to the synthetic and antitussive and antiasthmatic effect that promotes pulmonary surfactant.The two cholate po of hydrogen amber acid of enoxolone, its antitussive effect is similar to codeine.With Radix Glycyrrhizae same dose level the time, hydrocortisone also shows antitussive effect, but the dose response curve is different with Radix Glycyrrhizae, and invalid to the cough that stimulates the cat superior laryngeal nerve to cause, thinks that therefore Radix Glycyrrhizae antitussive effect and antiinflammatory are irrelevant but by the maincenter generation.Radix Glycyrrhizae can also promote throat and bronchial secretion, makes the easy expectoration of expectorant, presents the eliminating phlegm and relieving cough effect.Gypsum Fibrosum Great Cold, to give birth to for oral administration, external enwergy is separated the heat of strand table, internal energy clearing away heat-fire, promoting the production of body fluid to quench thirst is for controlling lung, stomach two through edema caused by disorder of QI excess-heat key medicine.Gypsum Fibrosum is at the phagocytic activity of external obvious enhancing pulmonary alveolar macrophage to the dead bacterium of Staphylococcus albus, and can promote cytophagous maturation, and the Gypsum Fibrosum external can reduce the distant property of blood vessel and play antiinflammation.

Summary of the invention

Technical problem solved by the invention is to provide a kind of Maxingshigan oral liquid and preparation method thereof, to solve the problem in the background technology:

Technical problem solved by the invention realizes by the following technical solutions:

1, the key component of Maxingshigan oral liquid is formed, and count by weight, raw material is mainly composed as follows: Gypsum Fibrosum 1000-2000 part, Herba Ephedrae 200-400 part, Semen Armeniacae Amarum 200-400 part, Radix Glycyrrhizae 200-400 part, multitudinous sugared 200-400 part, benzoic acid 2-4 part, ethyl hydroxybenzoate 2-4 part;

2. and by following processing step and technological parameter prepare:

Get Gypsum Fibrosum 1000-2000 part and be ground into coarse powder,, add water 3000-6000 part with Herba Ephedrae 200-400 part, Semen Armeniacae Amarum 200-400 part, Radix Glycyrrhizae 200-400 part and decoct twice with the gauze parcel, collecting decoction filters, and filtrate is concentrated into 500-1000 part, become the thick paste shape, add multitudinous sugared 200-400 part, benzoic acid 2-4 part, ethyl hydroxybenzoate 2-4 part, stir, leave standstill, filter, get 1000ml, fill, promptly.

The dark-brown thick liquid of the present invention; Be used for the lung-heat cough with asthma, heat clearing away, lung qi dispersing is relievingd asthma, and every 1L water adds 1.0～1.5ml this product and mixes drink.

In the present invention, the optimum formula ratio is: 1500 parts in Gypsum Fibrosum, 300 parts in Herba Ephedrae, 300 parts of Semen Armeniacae Amarums, 300 parts in Radix Glycyrrhizae, multitudinous sugared 300 parts, 3 parts in benzoic acid, 3 parts of ethyl hydroxybenzoates.

In the present invention, 5000 parts of the best amount of water of decoction, best 800 parts of the amounts that concentrate.

Authentication method of the present invention has three kinds, and is as follows:

(1) gets this product 2ml, add 1～2 of water 5ml and dilute hydrochloric acid, boiled 2～3 minutes, filter.Filtrate is put in the separatory funnel, adds the ammonia solution number and droplet makes alkalize, adds chloroform 5ml again, and jolting is extracted.Divide and get chloroform solution, put in two test tubes, each 5 of a pipe ammonification system chlorinated ketone test solution and Carbon bisulfide, jolting is left standstill, and chloroform layer shows buff; Another pipe replaces Carbon bisulfide, the colourless or micro-yellow of chloroform layer after the jolting for blank with 5 of chloroforms.

(2) get this product 5ml, put in the test tube, hang a trinitrophenol reagent paper in the test tube, use the cork jam-pack, put in the tepidarium, after 10 minutes, it is brick-red that reagent paper shows.

(3) get this product 10ml, the 20ml that adds diethyl ether put in the water-bath reflux 30 minutes, discard ether solution, residue adds methanol 20ml, puts in the water-bath reflux 1 hour, filter, filtrate evaporate to dryness, residue add water 30ml makes dissolving, aqueous solution water saturation n-butanol extraction 3 times, each 15ml merges n-butyl alcohol liquid, with the saturated water washing of n-butyl alcohol 3 times, discard water liquid, n-butyl alcohol liquid is put evaporate to dryness in the water-bath, residue adds methanol 5ml makes dissolving, as need testing solution.Extracting liquorice control medicinal material 1g shines medical material solution in pairs with legal system in addition.Extracting liquorice acid ammonium reference substance adds methanol and makes the solution that every 1ml contains 2mg, in contrast product solution again.According to thin layer chromatography (appendix * * page or leaf) test, draw each 5 μ l of above-mentioned three kinds of solution, put respectively in same be on the silica GF254 lamellae of adhesive with the sodium carboxymethyl cellulose, upper strata liquid with n-butyl alcohol-glacial acetic acid-water (6: 1: 3) is developing solvent, launch, take out, dry, put under the ultra-violet lamp (254nm) and inspect.In the test sample chromatograph, with control medicinal material and the corresponding position of reference substance chromatograph on, show the speckle of same color.

Clinical test results of the present invention is as follows:

(1) chooses the healthy chick of 30 ages in days, about average weight 0.65Kg, select 180 plumages, be divided into 6 groups at random, ad lib drinking-water; And adjust that respectively to organize body weight basic identical, to 5 groups of artificial onsets wherein, to chicken trachea virus inoculation KIB-C1 strain; anthology is invented the Maxingshigan oral liquid for preparing; infect dosage group (1.5ml/L drinking water) in the heavy dose of group of administration (2.0ml/L drinking water), the infection administration, infection administration small dose group (1.0ml/L drinking water), infection routine administration group (powerful cough with asthma spirit group) respectively, infect not administration group, do not infect not administration group; design experiment, route of administration and therapeutic dose are made table 1:

Table 1

(2), observe clinical manifestation, each counteracting toxic substances group is in infecting respiratory symptoms such as occurring cough, stridulating, breathe the gong sound in back 16 hours respectively, but appetite and drinking-water are normally; Purging pathogenic fire of the lung color loose stool after negative control group 4-5 days, part chicken occur spirit depressed, stay minimizings of standing, search for food, foot is dried, chicken began death in the 6th day, stopped after dead 6 days continuously; Respiratory symptoms such as each administration group is coughed, stridulated, gong sound begin after 3 days to alleviate in administration, compare with negative control group, and less appearances spirit is depressed, stay the minimizing of standing, search for food, the dried symptom of foot.Except that dead 8 of small dose group, all the other each groups are dead less.

Analysis result, make and drive the influence table 2 of ball dysentery relieving mixture the chicken growth:

Table 2

By experimental result as can be known, each administration group all has significant difference with the infection matched group as a result; The big or middle dosage group of Maxingshigan oral liquid effective percentage is respectively 90.0%, 93.3%, is higher than powerful cough with asthma spirit group 83.3%, but there was no significant difference.

Beneficial effect:

The Maxingshigan oral liquid technology controlling and process that the present invention makes is simple, the bioavailability height, and good drug efficacy, curative effect is fast, and cost is low.

The specific embodiment

Best embodiment of the present invention divides other scheme according to integral body, implements respectively, below by embodiment the present invention is specifically described:

Embodiment 1:

1, the key component of Maxingshigan oral liquid is formed, and counts by weight, and raw material is mainly composed as follows: 1000 parts in Gypsum Fibrosum, 250 parts in Herba Ephedrae, 250 parts of Semen Armeniacae Amarums, 250 parts in Radix Glycyrrhizae, multitudinous sugared 250 parts, 2.5 parts in benzoic acid, 2.5 parts of ethyl hydroxybenzoates;

2. and by following processing step and technological parameter prepare:

Get Gypsum Fibrosum and be ground into coarse powder for 1000 parts, with gauze parcel, with 250 parts in Herba Ephedrae, 250 parts of Semen Armeniacae Amarums, 250 parts in Radix Glycyrrhizae, add water and decoct twice for 4000 parts, collecting decoction filters, and filtrate is concentrated into 850 parts, become the thick paste shape, add multitudinous sugared 200-400 part, 2.5 parts in benzoic acid, 2.5 parts of ethyl hydroxybenzoates, stir, leave standstill, filter, get 1000ml, fill, promptly.

The Maxingshigan oral liquid of producing is mixed drinking water, 30 of the chickling of raising trouble asthma, every 1L water adds the 1.5ml Maxingshigan oral liquid, raises 27 chickling recoveries from illness 7 days.

Embodiment 2:

1, the key component of Maxingshigan oral liquid is formed, and counts by weight, and raw material is mainly composed as follows: 1500 parts in Gypsum Fibrosum, 300 parts in Herba Ephedrae, 300 parts of Semen Armeniacae Amarums, 300 parts in Radix Glycyrrhizae, multitudinous sugared 300 parts, 3 parts in benzoic acid, 3 parts of ethyl hydroxybenzoates;

2. and by following processing step and technological parameter prepare:

Get Gypsum Fibrosum and be ground into coarse powder for 1500 parts,, add water for 300 parts with 300 parts in Herba Ephedrae, 300 parts of Semen Armeniacae Amarums, Radix Glycyrrhizae and decoct twice for 5000 parts with the gauze parcel, collecting decoction filters, and filtrate is concentrated into 800 parts, become the thick paste shape, add multitudinous sugared 300 parts, 3 parts in benzoic acid, 3 parts of ethyl hydroxybenzoates, stir, leave standstill, filter, get 1000ml, fill, promptly.

The Maxingshigan oral liquid of producing is mixed drinking water, 30 of the young ducks of raising trouble lung-heat, every 1L water adds the 2ml Maxingshigan oral liquid, raises 29 young ducks recoveries from illness 6 days.

More than show and described ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; that describes in the foregoing description and the description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.The claimed scope of the present invention is defined by appending claims and equivalent thereof.

Claims (5)

1. the key component of Maxingshigan oral liquid is formed, and count by weight, it is characterized in that raw material is mainly composed as follows: Gypsum Fibrosum 1000-2000 part, Herba Ephedrae 200-400 part, Semen Armeniacae Amarum 200-400 part, Radix Glycyrrhizae 200-400 part, multitudinous sugared 200-400 part, benzoic acid 2-4 part, ethyl hydroxybenzoate 2-4 part.

2. Maxingshigan oral liquid according to claim 1 is characterized in that, described optimum formula ratio is: 1500 parts in Gypsum Fibrosum, 300 parts in Herba Ephedrae, 300 parts of Semen Armeniacae Amarums, 300 parts in Radix Glycyrrhizae, multitudinous sugared 300 parts, 3 parts in benzoic acid, 3 parts of ethyl hydroxybenzoates.

3. the Maxingshigan oral liquid preparation method is characterized in that, may further comprise the steps:

Get Gypsum Fibrosum 1000-2000 part and be ground into coarse powder,, add water 3000-6000 part with Herba Ephedrae 200-400 part, Semen Armeniacae Amarum 200-400 part, Radix Glycyrrhizae 200-400 part and decoct twice with the gauze parcel, collecting decoction filters, and filtrate is concentrated into 500-1000 part, become the thick paste shape, add multitudinous sugared 200-400 part, benzoic acid 2-4 part, ethyl hydroxybenzoate 2-4 part, stir, leave standstill, filter, get 1000ml, fill, promptly.

4. Maxingshigan oral liquid preparation method according to claim 3 is characterized in that, 5000 parts of the best amount of water of described decoction.

5. Maxingshigan oral liquid preparation method according to claim 3 is characterized in that, best 800 parts of the amounts that concentrate of described decoction.