CN104491062A - Castor root and green turnip based antitussive and antiasthmatic medicament and preparation method thereof - Google Patents
Castor root and green turnip based antitussive and antiasthmatic medicament and preparation method thereof Download PDFInfo
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- CN104491062A CN104491062A CN201410754705.2A CN201410754705A CN104491062A CN 104491062 A CN104491062 A CN 104491062A CN 201410754705 A CN201410754705 A CN 201410754705A CN 104491062 A CN104491062 A CN 104491062A
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Abstract
The invention discloses a castor root and green turnip based antitussive and antiasthmatic medicament and a preparation method thereof, belonging to traditional Chinese medicines, and particularly relating to an antitussive and antiasthmatic medicament and a preparation method thereof. The antitussive and antiasthmatic medicament comprises the following raw materials in parts by weight: 5-30 parts of ephedra, 5-30 parts of almond, 10-50 parts of gypsum, 1-20 parts of radix glycyrrhizae, 5-15 parts of castor roots and 30-50 parts of green turnips. The preparation method comprises the following steps: adding water into almond, distilling so as to obtain an almond solution, mixing decoction dregs with ephedra, gypsum and radix glycyrrhizae, adding water for decocting, filtering, standing overnight, and taking liquid supernatant; dicing castor roots and green turnips, adding water for decocting for over 30 minutes, filtering, standing overnight, and taking liquid supernatant; and mixing the two kinds of liquid supernatant, carrying out depressurized condensation so as to obtain clear paste, adding saccharose and sodium benzoate, boiling dissolve the mixture, filtering, cooling, adding the almond solution, adding water until quantification is implemented, and uniformly stirring, so that a finished product is obtained. According to the invention, just through adding castor roots and green turnips into a classic maxingshigan decoction, effects of depressing qi and eliminating phlegm can be achieved.
Description
Technical field
Belong to a Chinese medicine based on the antitussive and antiasthmatic medicine of Radix Ricini and green turnip and preparation method, be specifically related to a kind of antitussive and antiasthmatic medicine and preparation method.
Background technology
Coughing, panting is clinical common sympton, and can cause by flu, bronchitis etc. are sick, easily send out when season or weather conversion, ill have the symptom such as bottleneck throat pruritus, discomfort, rough abundant expectoration, hypopnea often, has a strong impact on rest, life.At present, though the medicine for the treatment of this type of disease is clinically many, curative effect is not to the utmost as entered meaning.
Doctor trained in Western medicine adopts the expelling phlegm drugs such as antitussive medicine and the ammonium chloride symptomatic treatments such as codeine to symptoms such as coughing, pant, though can accomplish temporarily to control symptom, but antibacterials such as using antibiotic must be merged to reach healing object, and antibiotic abuse can cause more serious consequence, the cough that some chronic bronchitis causes is unsuitable life-time service antibiotic therapy also.
Chinese medicine has more deep understanding to cough, the pathology and disease mechanism of panting, in its treatment, have obvious advantage, and wherein, MAXINGSHIGAN TANG is the eliminating evil classics recipe of lung qi dispersing, and the typical prescription of this side is:
Four liang, Herba Ephedrae, goes to save (6 grams)
50, Semen Armeniacae Amarum, peeling point (9 grams)
Two liang, Radix Glycyrrhizae, processs (3 grams)
Half jin, Gypsum Fibrosum, broken, brocade is wrapped up in (24 grams)
Though this prescription lung qi dispersing function is strong, its sending down the abnormal ascending QI, expectorant effect are still not enough, for this reason, application number is the patent of invention " a kind of medicine with relieving cough and asthma function " of 200510019055, on the basis of classical formula, add Semen Lepidii (Semen Descurainiae), Radix Platycodonis and Radix Peucedani, improve the effect of its lowering the adverse-rising QI and dispelling phlegm.
Semen Ricini is annual sturdy draft or herbaceous stem shrub, and its leaf is usually used in detumescence and drawing out poison, antipruritic.And its root is usually used in expelling wind and activating blood circulation, pain relieving is calm.
Radix Raphani is annual herb, is usually used in blood fat reducing, vessel softening, stabilizing blood pressure, the diseases such as prevention coronary heart disease, arteriosclerosis, cholelithiasis.
Radix Raphani is decocted together with the root of Semen Ricini, a kind of composition that can be used for sending down the abnormal ascending QI, eliminate the phlegm can be produced, but this composition does not also apply in the middle of medicine.If use it for cough-relieving, eliminate the phlegm, by the kind of this kind of for extreme enrichment medicine, for patient provides more selection.
Summary of the invention
In order to solve the problem, the invention discloses a kind of antitussive and antiasthmatic medicine based on Radix Ricini and green turnip and preparation method, this antitussive and antiasthmatic medicine only needs to add in classical MAXINGSHIGAN TANG the decoction that Radix Ricini and green turnip are boiled into, and can realize increasing sending down the abnormal ascending QI, expectorant effect.
The object of the present invention is achieved like this:
Based on an antitussive and antiasthmatic medicine for Radix Ricini and green turnip, the weight portion of each raw medicinal material is: Herba Ephedrae 5-30 part, Semen Armeniacae Amarum 5-30 part, Gypsum Fibrosum 10-50 part, Radix Glycyrrhizae 1-20 part, Radix Ricini 5 ~ 15 parts, green turnip 30-50 part.
A preparation method for the above-mentioned antitussive and antiasthmatic medicine based on Radix Ricini and green turnip, the weight portion of each raw medicinal material of syrup is: Herba Ephedrae 5-30 part, Semen Armeniacae Amarum 5-30 part, Gypsum Fibrosum 10-50 part, Radix Glycyrrhizae 1-20 part, Radix Ricini 5 ~ 15 parts, green turnip 30-50 part; Preparation method is that aqua armeniacae is produced in the Semen Armeniacae Amarum distillation that adds water, and medicinal residues and Herba Ephedrae, Gypsum Fibrosum, Radix Glycyrrhizae decoct with water, filter, hold over night, get supernatant; Decoct with water more than 30 minutes after Radix Ricini and green turnip being diced, filter, hold over night, gets supernatant; Concentrating under reduced pressure after two kinds of supernatant mixing is become clear paste, adds sucrose and sodium benzoate, boil and make dissolving, filter, let cool, add above-mentioned aqua armeniacae, add water to quantitatively, stir evenly, get product.
Beneficial effect:
The first, only need Radix Ricini and green turnip be added in traditional MAXINGSHIGAN TANG, sending down the abnormal ascending QI, expectorant effect can be increased.
The second, because Semen Ricini and green turnip are applicable to extensive establishing in large scale, therefore medical material is sufficient, is conducive to reducing price of medicinal material.
Three, the patent of invention being 200510019055 with application number is compared, and replaces Semen Lepidii (Semen Descurainiae), Radix Platycodonis and Radix Peucedani three taste medicine, can reach identical effect equally with Radix Ricini and green turnip.
Detailed description of the invention
Below the specific embodiment of the invention is described in further detail.
The antitussive and antiasthmatic medicine based on Radix Ricini and green turnip of the present embodiment, the weight portion of each raw medicinal material is: Herba Ephedrae 5-30 part, Semen Armeniacae Amarum 5-30 part, Gypsum Fibrosum 10-50 part, Radix Glycyrrhizae 1-20 part, Radix Ricini 5 ~ 15 parts, green turnip 30-50 part; Its preparation method is that aqua armeniacae is produced in the Semen Armeniacae Amarum distillation that adds water, and medicinal residues and Herba Ephedrae, Gypsum Fibrosum, Radix Glycyrrhizae decoct with water, filter, hold over night, get supernatant; Decoct with water more than 30 minutes after Radix Ricini and green turnip being diced, filter, hold over night, gets supernatant; Concentrating under reduced pressure after two kinds of supernatant mixing is become clear paste, adds sucrose and sodium benzoate, boil and make dissolving, filter, let cool, add above-mentioned aqua armeniacae, add water to quantitatively, stir evenly, get product.
Do pharmacodynamics test, acute toxicity test, long term toxicity test with the syrup that this embodiment is produced, result of the test is as follows:
1, Pharmacodynamic test of active extract
Results of animal shows, this product all demonstrates certain protective effect to the mortality rate after mouse infection staphylococcus aureus, Hemolytic streptococcus and klepsiella pneumoniae; On Carrageenan causes mice pedal swelling inflammation and granuloma induced by implantation of cotton pellets chronic inflammatory disease also has obvious inhibitory action; There is obvious prolongation effect incubation period ammonia being caused to mouse cough, and obviously can suppress its cough number of times, also there is obvious prolongation effect incubation period citric acid being sprayed to guinea pig cough, and obviously can suppress its cough number of times: the phenol red secretion test of mice also shows that it has obvious resolve phlegm effect.In addition guinea pig bronchial spastic contractions is caused also to demonstrate certain inhibitory action to histamine.
Above result of the test shows that this product has relieving cough and resolving phlegm, relievings asthma, antiinflammatory, antianaphylactic effect.
2, acute toxicity test
In mice 24 hours, gavage gives this syrup and reaches 225 times that 158.55g crude drug/kg(is equivalent to people's quantity 42. 3g crude drug/60kg), have no it and have anomalous effects to situations such as mice activity, defecation and psychoreactions, also end is increased on Mouse Weight and sees there is impact, during administration and viewing duration also without animal dead.Therefore, think that this syrup acute toxicity is lower.
3, long term toxicity test
Getting Wistar rat is test group.Each rats in test groups gives that dosage is 42.3 respectively, this syrup of 21.2,10. 6g crude drug/kg (be equivalent to about respectively 60,30,15 times that people intends consumption clinical day), and continuous gastric infusion 4 weeks, carries out the research of this syrup long term toxicity.Result of the test shows, this syrup high dose group (60 times), middle dosage group (30 times) and low dose group (15 times) each observation index compare with blank group, have been showed no obvious abnormal change.
Long term toxicity test result shows, this product is safe by the clinical dosage drafted, route of administration and the application course for the treatment of.
Based on the preparation method of this embodiment, part material is replaced, and carry out pharmacodynamics test.
It is as shown in the table for substitute mode
| Battery of tests | Second group of test | 3rd group of test | 4th group of test | |
| Before replacement | Radix Ricini | Green turnip | Green turnip | Green turnip |
| After replacement | Folium Ricini | Radix Dauci Sativae | Radix Dauci Sativae | White turnip |
Results of animal shows, the component after replacement, to the mortality rate after mouse infection staphylococcus aureus, Hemolytic streptococcus and klepsiella pneumoniae without obvious protective effect; The inhibitory action that on Carrageenan causes mice pedal swelling inflammation and granuloma induced by implantation of cotton pellets chronic inflammatory disease is not obvious; Preclinical prolongation effect ammonia being caused to mouse cough is not obvious, to suppressing the effect of its cough number of times not as replacing front component, preclinical prolongation effect citric acid being sprayed to guinea pig cough is not obvious, to suppressing the effect of its cough number of times not as replacing front component: mice phenol red secretion test shows that its resolve phlegm effect is not obvious.In addition guinea pig bronchial spastic contractions is caused also to demonstrate weak inhibitory action to histamine.
Therefore, the component mixing of Radix Ricini and green turnip is most preferred composition.
The present invention is not limited to above-mentioned preferred forms, and anyone should learn the structure change or method improvement made under enlightenment of the present invention, and every have identical or close technical scheme with the present invention, all falls within protection scope of the present invention.
Claims (2)
1., based on an antitussive and antiasthmatic medicine for Radix Ricini and green turnip, it is characterized in that, the weight portion of each raw medicinal material is: Herba Ephedrae 5-30 part, Semen Armeniacae Amarum 5-30 part, Gypsum Fibrosum 10-50 part, Radix Glycyrrhizae 1-20 part, Radix Ricini 5 ~ 15 parts, green turnip 30-50 part.
2. described in a claim 1 based on the preparation method of the antitussive and antiasthmatic medicine of Radix Ricini and green turnip, it is characterized in that, the weight portion of each raw medicinal material of syrup is: Herba Ephedrae 5-30 part, Semen Armeniacae Amarum 5-30 part, Gypsum Fibrosum 10-50 part, Radix Glycyrrhizae 1-20 part, Radix Ricini 5 ~ 15 parts, green turnip 30-50 part; Preparation method is that aqua armeniacae is produced in the Semen Armeniacae Amarum distillation that adds water, and medicinal residues and Herba Ephedrae, Gypsum Fibrosum, Radix Glycyrrhizae decoct with water, filter, hold over night, get supernatant; Decoct with water more than 30 minutes after Radix Ricini and green turnip being diced, filter, hold over night, gets supernatant; Concentrating under reduced pressure after two kinds of supernatant mixing is become clear paste, adds sucrose and sodium benzoate, boil and make dissolving, filter, let cool, add above-mentioned aqua armeniacae, add water to quantitatively, stir evenly, get product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410754705.2A CN104491062A (en) | 2014-12-11 | 2014-12-11 | Castor root and green turnip based antitussive and antiasthmatic medicament and preparation method thereof |
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| CN201410754705.2A CN104491062A (en) | 2014-12-11 | 2014-12-11 | Castor root and green turnip based antitussive and antiasthmatic medicament and preparation method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1520867A (en) * | 2003-01-28 | 2004-08-18 | 吴守礼 | Medicine for stopping smoking and preparing process thereof |
| CN101869612A (en) * | 2010-06-08 | 2010-10-27 | 江西中成药业集团有限公司 | Maxingshigan oral liquid and preparation method thereof |
-
2014
- 2014-12-11 CN CN201410754705.2A patent/CN104491062A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1520867A (en) * | 2003-01-28 | 2004-08-18 | 吴守礼 | Medicine for stopping smoking and preparing process thereof |
| CN101869612A (en) * | 2010-06-08 | 2010-10-27 | 江西中成药业集团有限公司 | Maxingshigan oral liquid and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 王超楠等: "天津‘卫青萝卜’的营养保健功效及科学食用方法", 《天津农业科学》 * |
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