WO2016183780A1

WO2016183780A1 - Traditional chinese medicine for treating asthma

Info

Publication number: WO2016183780A1
Application number: PCT/CN2015/079208
Authority: WO
Inventors: 张甘霖
Original assignee: 张甘霖
Priority date: 2015-05-18
Filing date: 2015-05-18
Publication date: 2016-11-24

Abstract

A traditional Chinese medicine for treating asthma. The traditional Chinese medicine is prepared from the following raw medicinal materials in parts by weight: 7 parts of white mustard seed, 0.5 parts of kansui root, 5 parts of corydalis tuber, 3 parts of wild ginger, 6 parts of Arisaema heterophyllum, 16 parts of coelogyne cristata, and 0.3 parts of datura flowers.

Description

Traditional Chinese medicine for treating asthma

Technical field

The invention relates to a traditional Chinese medicine, in particular to a traditional Chinese medicine for treating asthma.

Background technique

Asthma is a chronic inflammation of the airway formed by the participation of mast cells, eosinophils and T lymphocytes, which seriously endangers public health. According to incomplete statistics, there are more than 300 million bronchial asthma patients in the world, and the incidence of asthma is increasing year by year. At present, Western medicine mainly uses glucocorticoids, anticholinergic drugs, β2 receptor agonists, leukotriene receptor antagonists and other drugs. Although it can achieve certain curative effect, there is no clear stopping index for how long it should be used. In addition, Western medicine has a single target and is easy to produce drug resistance. Oral glucocorticoids have problems such as hormone dependence, hormone resistance, and side effects. Even with local aerosol inhalation of hormones, the safety of long-term medication is not fully understood. Chinese medicine believes that asthma is a long-term sipping, causing sputum to block the airway, and the disease is caused by abnormality. In the attack period, more phlegm, lowering qi, and relieving asthma to cure the symptoms. In the remission period, the lungs, spleen and kidneys are adjusted to cure the disease, internal treatment, external treatment or internal and external treatment. The methods are diverse and the adverse reactions are less and more and more The majority of doctors and patients are favored.

The research status of the medicinal materials involved in the present invention is as follows:

White mustard [alias] spicy colza [source] is the seed of the cruciferous plant Sinapis alba L. [Habitat distribution] is native to Europe. China's Liaoning, Shanxi, Xinjiang, Shandong, Anhui, Sichuan, Yunnan have many cultivation. [sexual taste] Xin; warm. [Functions and Indications] phlegm and phlegm drink; The main cough and wheezing; chest full of hypochondriac pain; limb numbness; joint swelling and pain; wet sputum flow; sputum swelling. [Usage and Dosage] Oral: Jiantang, 3-10g; or into the pill, scattered. External use: appropriate amount, research and dressing; cure asthma cough should be applied to the back of the lungs, heart Yu, sipping. [Excerpt] "Chinese Materia Medica".

Ganzi [alias] main field, heavy picture, Ganzi, Lingling, Ganze, bitter, Baize, ghost ugly, Lingze [source] is the root of the scorpion plant Ganzi. [Sexual taste] bitter taste; cold. [Return to the spleen; lung; kidney; bladder; large intestine; small intestine. [Functions and Indications] diarrhea and drinking; Main edema; ascites; drink and chest; epilepsy; asthma cough; [Usage and Dosage] Oral: Into the pill, scattered, 0.5-1g. [Excerpt] "Chinese Materia Medica".

Yanhusuo [alias] Xuanhusu, Yuanhu [source] This product is the dry tubers of the poppy family Corydalis yanhusuo W.T.Wang. When the stems and leaves are withered in the early summer, the roots are removed, the roots are removed, washed, and boiled in boiling water until there is no white heart, taken out and dried. [Sexual taste] Xin, bitter, warm. [Indications] Activating blood, benefiting, and relieving pain. For chest flank, abdominal pain, menstrual dysmenorrhea, postpartum stagnation, swelling and swelling. [Usage and Dosage] 3-9g; swallowed at the end of the study, once 1.5-3g. [Excerpt] "Chinese Materia Medica".

Asahi [alias] Xiaoxin, fine grass, Shaoxin, thin strips, green ginger, unicorn, golden potted grass [source] for the roots of the Aristolochia family Liao Xixin, Asahi and Seoul Asahi grass. The transplanted field is grown for 3-5 years, and the live growing is 5-6 harvested. In the middle of September, all the roots were dug out, and the soil was removed. Each 1-2 kg was bundled into one, and it was placed in a cool place and then packaged into the warehouse. [sexual taste] Xin; warm. [Functions and Indications] Dispelling cold and hurricane; relieving pain; warming lungs and drinking; Main cold and cold syndrome; headache, toothache; rheumatism and pain; sputum and cough; nasal congestion; nose; mouth sores. [Usage and dosage] Service: Jiantang, 1.5-9g; powder, 1-3g. [Excerpt] "Chinese Materia Medica".

Tiannanxing [alias] Pinellia lucidum, Ghost Southern Star, Tiger Cream, Snake Python, Wild Donkey Head, Snake Python, Mountain glutinous rice, Snake Valley, Mountain stalk [Source] is the Tiannan Star Plant, Tiger Palm, Tiannan Star, An Umbrella South Star and Northeast Tuber of Araceae. [Sexual taste] bitter taste; Xin; sexual temperature. [Functions and Indications] 祛痉痉痉; The main stroke is sputum; the mouth is arbitrarily arbitrarily; the body is not paralyzed; the hands and feet are paralyzed; the wind is dizzy; the epilepsy; the convulsions; the tetanus; the cough and phlegm; the swelling; the phlegm; the numbness; the snake bite. [Usage and Dosage] Oral: Jiantang, 3-9g, generally used after the system: or into the pill. External use: the amount of raw food, the end of the study with vinegar or wine. [Excerpt] "Chinese Materia Medica".

Fritillaria [alias] stone banana, leaf fruit, fruit upper leaves, hemostatic fruit, small green 芨 [source] This product is a fake bulb or whole grass of Orchidaceae plant umbrella family. It can be harvested all year round, washed, steamed, dried or freshly used. [Sexual taste] Xin; Gan; cool. [Indications] heat and cough; stop bleeding and pain. Main bronchitis; cold; fracture; soft tissue contusion; traumatic bleeding. [Usage and Dosage] Oral: Jiantang, 15-30g. External use: appropriate amount, fresh product, or dry product. . [Excerpt] "Chinese Materia Medica".

Yangjinhua [alias] Manro flower, Mandala flower, Chiba mandala flower, layered mandala flower [Source] This product is a flower of the Solanaceae plant white mandala, hair mandala. In the flowering period from late July to late August, picking and drying in the afternoon at 4-5 pm can be dried at 50-60 ° C for 4-6 h. [Sexual taste] Weixin; sexual temperature. [Return to the lungs] liver; liver. [Indications] smooth and cough; anesthesia and pain relief; Primary asthma cough; abdominal cold breeding; rheumatic pain; epilepsy; convulsions; surgical anesthesia. [Usage and Dosage] Service: Jiantang, 0.3-0.5g, should be used in pills and scattered. [Excerpt] "Chinese Materia Medica".

Summary of the invention

The present invention aims to provide a traditional Chinese medicine for treating asthma by selecting a suitable medicinal material and its ratio. Achieve safe and effective cure of asthma.

In order to achieve the above object, the present invention adopts the following technical solutions:

A traditional Chinese medicine for treating asthma, which is prepared from the following raw materials of weight ratio: 7 parts of white mustard, 0.5 part of kansui, 5 parts of Corydalis, 3 parts of Asarum, 6 parts of Araceae, 16 copies of Fritillaria and 0.3 copies of Yang Jinhua.

The beneficial effects of the present invention will be described below in conjunction with clinical experimental data:

1. General information

The inventors collected a total of 60 asthma patients from September 2010 to April 2013, all of which met the diagnostic criteria for asthma. The age, sex, and duration of the two groups of patients are shown in Tables 1 to 3.

Table 1 Comparison of age (years) of two groups of patients

Table 2 Comparison of gender between the two groups

Table 3 Comparison of the course of the two groups (months)

From Tables 1 to 3, it can be seen that the basic data of the two groups were more than 0.05, that is, there was no significant difference in the clinical basic data between the two groups, which was comparable.

2, test methods

2.1 treatment methods

The treatment group orally took the decoction prepared according to the specific example 1 of the present invention 3 times a day. The course of treatment is 4 weeks.

The control group received oral ketotifen (produced by Shandong Jining Second Pharmaceutical Factory) (according to its instructions) for 4 weeks.

All patients were followed up once a week during the treatment period, and the efficacy statistics were performed after 4 weeks.

3, efficacy standards and treatment results

3.1 efficacy standard

Refer to the "Guidelines for Clinical Research of New Drugs in Traditional Chinese Medicine" (2002) for efficacy evaluation:

Healing: wheezing symptoms and lung sounds disappear or are not light;

Significant effect: wheezing symptoms and lung sounds improved significantly;

Effective: wheezing symptoms and lung sounds have improved;

Invalid: Wheezing symptoms and lung sounds are not improved or aggravated.

3.2 treatment results

The statistics of the total clinical efficacy of the two groups are shown in Table 4.

Table 4 Comparison of clinical effects between the two groups

The chi-square test was performed on the two groups of treatment results, x ² =8.58, P=0.035<0.05, that is, the therapeutic effect of the treatment group was significantly better than that of the control group. It can be seen that the invention has high recovery rate for treating asthma and has the value of popularization and application.

detailed description

For a better understanding and implementation of the present invention, the invention will be further described in conjunction with the specific embodiments.

Example 1

Weighed: 7 grams of white mustard, 0.5 grams of kansui, 5 grams of Corydalis, 3 grams of asarum, 6 grams of Tiannanxing, 16 grams of Fritillaria, 0.3 grams of Yangjinhua; add 8 times the amount of water, decoct for 1.5 hours, and filter; The filter residue was added with 6 times of water, decocted for 1 hour, and filtered; the filtrate was combined and concentrated to 120 g to obtain a decoction in accordance with the daily dosage of normal adults.

Used to treat asthma. Oral, taken three times a day, morning, evening and evening.

Example 2

Weighed: 7 grams of white mustard, 0.5 grams of kansui, 5 grams of Corydalis, 3 grams of asarum, 6 grams of Tiannanxing, 16 grams of Fritillaria, 0.3 grams of Yangjinhua; add 10 times the amount of water, boil for 2 hours, filter; The filter residue was added with 8 times of water, decocted for 1.5 hours, and filtered; the filtrate was combined, concentrated, dried, and packaged to obtain a powder that meets the daily dosage of normal adults.

Example 3

Weighing: 7 grams of white mustard, 0.5 grams of kansui, 5 grams of Corydalis, 3 grams of asarum, 6 grams of Tiannanxing, 16 grams of Fritillaria, 0.3 grams of Yangjinhua; add 6 times the amount of water, cook for 3 times, each time Decoction for 1 hour, combined with decoction, concentrated, dried, and filled into the capsule shell, which is a capsule that meets the daily dosage of normal adults.

Claims

A traditional Chinese medicine for treating asthma, wherein it is prepared from the following raw materials of weight ratio: 7 parts of white mustard, 0.5 part of kansui, 5 parts of Corydalis, 3 parts of Asarum, 6 parts of Araceae, Fritillaria 16 copies of orchid and 0.3 copies of Yang Jinhua.
The traditional Chinese medicine for treating asthma according to claim 1, wherein the preparation method comprises the following steps: weighing: 7 parts of white mustard, 0.5 part of kansui, 5 parts of Corydalis, 3 parts of Asarum, 6 parts of Araceae, Fritillaria. 16 parts, Yangjinhua 0.3 parts; add 8 times the amount of water, decoct for 1.5 hours, filter; filter residue plus 6 times the amount of water, decoct for 1 hour, filter; combine the filtrate, concentrate to 120 parts, then decoction; Both refer to parts by weight.
The traditional Chinese medicine for treating asthma according to claim 1, wherein the preparation method comprises the following steps: weighing: 7 parts of white mustard, 0.5 part of kansui, 5 parts of Corydalis, 3 parts of Asarum, 6 parts of Araceae, Fritillaria. 16 parts, Yangjinhua 0.3 parts; add 10 times the amount of water, decoct for 2 hours, filter; filter residue plus 8 times the amount of water, decoct for 1.5 hours, filter; combine the filtrate, concentrate, dry, package, that is, the powder; Both refer to parts by weight.
The traditional Chinese medicine for treating asthma according to claim 1, wherein the preparation method comprises the following steps: weighing: 7 parts of white mustard, 0.5 part of kansui, 5 parts of Corydalis, 3 parts of Asarum, 6 parts of Araceae, Fritillaria. 16 parts, Yang Jinhua 0.3 parts; add 6 times the amount of water, decocted 3 times, each time boiling for 1 hour, combined with decoction, concentrated, dried, and filled into the capsule shell, that is, capsules; the above refers to Parts by weight.