CN104491198A - Gmelina-based medicine capable of relieving cough and asthma and preparation method thereof - Google Patents
Gmelina-based medicine capable of relieving cough and asthma and preparation method thereof Download PDFInfo
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- A61K2236/30—Extraction of the material
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Abstract
The invention discloses a gmelina-based medicine capable of relieving cough and asthma and a preparation method thereof, belongs to the traditional Chinese medicine and in particular relates to a medicine capable of relieving cough and asthma and a preparation method thereof. The gmelina-based medicine is prepared from the following raw materials in parts by weight: 5-30 parts of ephedra, 5-30 parts of almond, 10-50 parts of gypsum, 1-20 parts of liquorice and 3-5 parts of gmelina leaves. The preparation method of the gmelina-based medicine comprises the conventional following steps: decocting, filtering, standing, concentrating into a clear paste, cooling, stirring and distilling, wherein the gmelina-based medicine is prepared into sirups, soft extracts, mixtures, tablets or capsules. By virtue of the gmelina-based medicine, the effects of depressing qi and eliminating phlegm can be achieved by only adding gmelina leaves into the classical maxingshigan decoction.
Description
Technical field
Belong to a Chinese medicine based on the antitussive and antiasthmatic medicine of Ramulus et Folium Gmelinae and preparation method, be specifically related to a kind of antitussive and antiasthmatic medicine and preparation method.
Background technology
Coughing, panting is clinical common sympton, and can cause by flu, bronchitis etc. are sick, easily send out when season or weather conversion, ill have the symptom such as bottleneck throat pruritus, discomfort, rough abundant expectoration, hypopnea often, has a strong impact on rest, life.At present, though the medicine for the treatment of this type of disease is clinically many, curative effect is not to the utmost as entered meaning.
Doctor trained in Western medicine adopts the expelling phlegm drugs such as antitussive medicine and the ammonium chloride symptomatic treatments such as codeine to symptoms such as coughing, pant, though can accomplish temporarily to control symptom, but antibacterials such as using antibiotic must be merged to reach healing object, and antibiotic abuse can cause more serious consequence, the cough that some chronic bronchitis causes is unsuitable life-time service antibiotic therapy also.
Chinese medicine has more deep understanding to cough, the pathology and disease mechanism of panting, in its treatment, have obvious advantage, and wherein, MAXINGSHIGAN TANG is the eliminating evil classics recipe of lung qi dispersing, and the typical prescription of this side is:
Four liang, Herba Ephedrae, goes to save (6 grams)
50, Semen Armeniacae Amarum, peeling point (9 grams)
Two liang, Radix Glycyrrhizae, processs (3 grams)
Half jin, Gypsum Fibrosum, broken, brocade is wrapped up in (24 grams)
Though this prescription lung qi dispersing function is strong, its sending down the abnormal ascending QI, expectorant effect are still not enough, for this reason, application number is the patent of invention " a kind of medicine with relieving cough and asthma function " of 200510019055, on the basis of classical formula, add Semen Lepidii (Semen Descurainiae), Radix Platycodonis and Radix Peucedani, improve the effect of its lowering the adverse-rising QI and dispelling phlegm.
Ramulus et Folium Gmelinae is usually used in blood circulation promoting and blood stasis dispelling, pain relieving of drying, but its function of eliminating the phlegm also is not employed, if Ramulus et Folium Gmelinae is used for cough-relieving, eliminates the phlegm, by the kind of this kind of for extreme enrichment medicine, for patient provides more selection.
Summary of the invention
In order to solve the problem, the invention discloses a kind of antitussive and antiasthmatic medicine based on Ramulus et Folium Gmelinae and preparation method, this antitussive and antiasthmatic medicine only needs to add Ramulus et Folium Gmelinae leaves in classical MAXINGSHIGAN TANG, and can realize increases sending down the abnormal ascending QI, expectorant effect.
The object of the present invention is achieved like this:
Based on an antitussive and antiasthmatic medicine for Ramulus et Folium Gmelinae, the weight portion of each raw medicinal material is: Herba Ephedrae 5-30 part, Semen Armeniacae Amarum 5-30 part, Gypsum Fibrosum 10-50 part, Radix Glycyrrhizae 1-20 part, Ramulus et Folium Gmelinae leaves 3-5 part.
A preparation method for the above-mentioned antitussive and antiasthmatic medicine based on Ramulus et Folium Gmelinae, the weight portion of each raw medicinal material of syrup is: Herba Ephedrae 5-30 part, Semen Armeniacae Amarum 5-30 part, Gypsum Fibrosum 10-50 part, Radix Glycyrrhizae 1-20 part, Ramulus et Folium Gmelinae leaves 3-5 part; Preparation method is that aqua armeniacae is produced in the Semen Armeniacae Amarum distillation that adds water, and medicinal residues and all the other four Chinese medicine materials decoct with water, filter, hold over night, get supernatant concentrating under reduced pressure and become clear paste, add sucrose and sodium benzoate, boil and make dissolving, filter, let cool, add above-mentioned aqua armeniacae, add water to quantitatively, stir evenly, get product.
A preparation method for the above-mentioned antitussive and antiasthmatic medicine based on Ramulus et Folium Gmelinae, the weight portion of each raw medicinal material of soft extract is: Herba Ephedrae 5-30 part, Semen Armeniacae Amarum 5-30 part, Gypsum Fibrosum 10-50 part, Radix Glycyrrhizae 1-20 part, Ramulus et Folium Gmelinae leaves 3-5 part; Preparation method is Herba Ephedrae, Semen Armeniacae Amarum adds water, and distillate is produced in distillation, and medicinal residues and all the other samadhi medical materials decoct with water, filter, hold over night, get supernatant concentrating under reduced pressure and become thick paste; Separately get sucrose and make syrup, add above-mentioned thick paste and refined honey, be concentrated into appropriate, let cool, add above-mentioned distillate, stir evenly, subpackage, packaging gets product.
A preparation method for the above-mentioned antitussive and antiasthmatic medicine based on Ramulus et Folium Gmelinae, the weight portion of each raw medicinal material of mixture is: Herba Ephedrae 5-30 part, Semen Armeniacae Amarum 5-30 part, Gypsum Fibrosum 10-50 part, Radix Glycyrrhizae 1-20 part, Ramulus et Folium Gmelinae leaves 3-5 part; Preparation method is Herba Ephedrae, Semen Armeniacae Amarum adds water, and distillate is produced in distillation, and medicinal residues and its excess-three taste medical material decoct with water, and filters, hold over night, get supernatant concentrating under reduced pressure and become thick paste, add sucrose and sodium benzoate, boil and make dissolving, filter, let cool, add above-mentioned aqua armeniacae, add water to quantitatively, stir evenly, to obtain final product.
A preparation method for the above-mentioned antitussive and antiasthmatic medicine based on Ramulus et Folium Gmelinae, each raw medicinal material weight portion of tablet is: Herba Ephedrae 5-30 part, Semen Armeniacae Amarum 5-30 part, Gypsum Fibrosum 10-50 part, Radix Glycyrrhizae 1-20 part, Ramulus et Folium Gmelinae leaves 3-5 part; Making each technique is that gomi herbs decocts with water, and filter, hold over night, gets supernatant concentrating under reduced pressure and become thick paste, drying and crushing, granulates, tabletting.
A preparation method for the above-mentioned antitussive and antiasthmatic medicine based on Ramulus et Folium Gmelinae, the weight portion of each raw medicinal material of capsule is: Herba Ephedrae 5-30 part, Semen Armeniacae Amarum 5-30 part, Gypsum Fibrosum 10-50 part, Radix Glycyrrhizae 1-20 part, Ramulus et Folium Gmelinae leaves 3-5 part; Preparation method is that aqua armeniacae is produced in the Semen Armeniacae Amarum distillation that adds water, and medicinal residues and all the other four Chinese medicine materials decoct with water, filter, hold over night, get supernatant concentrating under reduced pressure and become clear paste, add sucrose and sodium benzoate, boil and make dissolving, filter, let cool, add above-mentioned aqua armeniacae, add water to quantitatively, stir evenly, get product.
The preparation method of all antitussive and antiasthmatic medicines based on Ramulus et Folium Gmelinae above, the preparation method of described Ramulus et Folium Gmelinae leaves is: de-stone Catalpa ovata Don. leaf, dry, be ground into powder.
Beneficial effect:
The first, only Ramulus et Folium Gmelinae leaves need be added in traditional MAXINGSHIGAN TANG, sending down the abnormal ascending QI, expectorant effect can be increased.
The second, because Ramulus et Folium Gmelinae primary growth is very fast, vigorous period can continue more than 60 years, and therefore medical material is sufficient, is conducive to reducing price of medicinal material.
Three, the patent of invention being 200510019055 with application number is compared, and replaces Semen Lepidii (Semen Descurainiae), Radix Platycodonis and Radix Peucedani three taste medicine, can reach identical effect equally with Ramulus et Folium Gmelinae leaves.
Four, the patent of invention being 200510019055 with application number is compared, adopt the number of Ramulus et Folium Gmelinae leaves to be less than Semen Lepidii (Semen Descurainiae), Radix Platycodonis and Radix Peucedani three taste medicine number summation, therefore the efficacy of a drug is stronger.
Detailed description of the invention
Below the specific embodiment of the invention is described in further detail.
Specific embodiment one
Present embodiments provide a kind of antitussive and antiasthmatic syrup based on Ramulus et Folium Gmelinae and preparation method, the weight portion of each raw medicinal material of syrup is: Herba Ephedrae 10g part, Semen Armeniacae Amarum 10g, Gypsum Fibrosum 30g, Radix Glycyrrhizae 10g, Ramulus et Folium Gmelinae leaves 3g; Preparation method is that aqua armeniacae is produced in the Semen Armeniacae Amarum distillation that adds water, and medicinal residues and all the other four Chinese medicine materials decoct with water, filter, hold over night, get supernatant concentrating under reduced pressure and become clear paste, add sucrose and sodium benzoate, boil and make dissolving, filter, let cool, add above-mentioned aqua armeniacae, add water to quantitatively, stir evenly, get product.
Specific embodiment two
Present embodiments provide a kind of antitussive and antiasthmatic soft extract based on Ramulus et Folium Gmelinae and preparation method, the weight portion of each raw medicinal material of soft extract is: Herba Ephedrae 10g part, Semen Armeniacae Amarum 10g, Gypsum Fibrosum 30g, Radix Glycyrrhizae 10g, Ramulus et Folium Gmelinae leaves 3g; Preparation method is Herba Ephedrae, Semen Armeniacae Amarum adds water, and distillate is produced in distillation, and medicinal residues and all the other samadhi medical materials decoct with water, filter, hold over night, get supernatant concentrating under reduced pressure and become thick paste; Separately get sucrose and make syrup, add above-mentioned thick paste and refined honey, be concentrated into appropriate, let cool, add above-mentioned distillate, stir evenly, subpackage, packaging gets product.
Specific embodiment three
Present embodiments provide a kind of antitussive and antiasthmatic mixture based on Ramulus et Folium Gmelinae and preparation method, the weight portion of each raw medicinal material of mixture is: Herba Ephedrae 10g part, Semen Armeniacae Amarum 10g, Gypsum Fibrosum 30g, Radix Glycyrrhizae 10g, Ramulus et Folium Gmelinae leaves 3g; Preparation method is Herba Ephedrae, Semen Armeniacae Amarum adds water, and distillate is produced in distillation, and medicinal residues and its excess-three taste medical material decoct with water, and filters, hold over night, get supernatant concentrating under reduced pressure and become thick paste, add sucrose and sodium benzoate, boil and make dissolving, filter, let cool, add above-mentioned aqua armeniacae, add water to quantitatively, stir evenly, to obtain final product.
Specific embodiment four
Present embodiments provide a kind of antitussive and antiasthmatic tablet based on Ramulus et Folium Gmelinae and preparation method, each raw medicinal material weight portion of tablet is: Herba Ephedrae 10g part, Semen Armeniacae Amarum 10g, Gypsum Fibrosum 30g, Radix Glycyrrhizae 10g, Ramulus et Folium Gmelinae leaves 3g; Making each technique is that gomi herbs decocts with water, and filter, hold over night, gets supernatant concentrating under reduced pressure and become thick paste, drying and crushing, granulates, tabletting.
Specific embodiment five
Present embodiments provide a kind of antitussive and antiasthmatic capsule based on Ramulus et Folium Gmelinae and preparation method, the weight portion of each raw medicinal material of capsule is: Herba Ephedrae 10g part, Semen Armeniacae Amarum 10g, Gypsum Fibrosum 30g, Radix Glycyrrhizae 10g, Ramulus et Folium Gmelinae leaves 3g; Preparation method is that aqua armeniacae is produced in the Semen Armeniacae Amarum distillation that adds water, and medicinal residues and all the other four Chinese medicine materials decoct with water, filter, hold over night, get supernatant concentrating under reduced pressure and become clear paste, add sucrose and sodium benzoate, boil and make dissolving, filter, let cool, add above-mentioned aqua armeniacae, add water to quantitatively, stir evenly, get product.
In above embodiment, the preparation method of Ramulus et Folium Gmelinae leaves is: de-stone Catalpa ovata Don. leaf, dry, be ground into powder.
Do pharmacodynamics test, acute toxicity test, long term toxicity test with the syrup that EXAMPLE l in present specification is produced, result of the test is as follows:
1, Pharmacodynamic test of active extract
Results of animal shows, this product all demonstrates certain protective effect to the mortality rate after mouse infection staphylococcus aureus, Hemolytic streptococcus and klepsiella pneumoniae; On Carrageenan causes mice pedal swelling inflammation and granuloma induced by implantation of cotton pellets chronic inflammatory disease also has obvious inhibitory action; There is obvious prolongation effect incubation period ammonia being caused to mouse cough, and obviously can suppress its cough number of times, also there is obvious prolongation effect incubation period citric acid being sprayed to guinea pig cough, and obviously can suppress its cough number of times: the phenol red secretion test of mice also shows that it has obvious resolve phlegm effect.In addition guinea pig bronchial spastic contractions is caused also to demonstrate certain inhibitory action to histamine.
Above result of the test shows that this product has relieving cough and resolving phlegm, relievings asthma, antiinflammatory, antianaphylactic effect.
2, acute toxicity test
In mice 24 hours, gavage gives this syrup and reaches 225 times that 158.55g crude drug/kg(is equivalent to people's quantity 42. 3g crude drug/60kg), have no it and have anomalous effects to situations such as mice activity, defecation and psychoreactions, also end is increased on Mouse Weight and sees there is impact, during administration and viewing duration also without animal dead.Therefore, think that this syrup acute toxicity is lower.
3, long term toxicity test
Getting Wistar rat is test group.Each rats in test groups gives that dosage is 42.3 respectively, this syrup of 21.2,10. 6g crude drug/kg (be equivalent to about respectively 60,30,15 times that people intends consumption clinical day), and continuous gastric infusion 4 weeks, carries out the research of this syrup long term toxicity.Result of the test shows, this syrup high dose group (60 times), middle dosage group (30 times) and low dose group (15 times) each observation index compare with blank group, have been showed no obvious abnormal change.
Long term toxicity test result shows, this product is safe by the clinical dosage drafted, route of administration and the application course for the treatment of.
The present invention is not limited to above-mentioned preferred forms, and anyone should learn the structure change or method improvement made under enlightenment of the present invention, and every have identical or close technical scheme with the present invention, all falls within protection scope of the present invention.
Claims (7)
1. based on an antitussive and antiasthmatic medicine for Ramulus et Folium Gmelinae, it is characterized in that, the weight portion of each raw medicinal material is: Herba Ephedrae 5-30 part, Semen Armeniacae Amarum 5-30 part, Gypsum Fibrosum 10-50 part, Radix Glycyrrhizae 1-20 part, Ramulus et Folium Gmelinae leaves 3-5 part.
2. described in claim 1 based on a preparation method for the antitussive and antiasthmatic medicine of Ramulus et Folium Gmelinae, it is characterized in that, the weight portion of each raw medicinal material of syrup is: Herba Ephedrae 5-30 part, Semen Armeniacae Amarum 5-30 part, Gypsum Fibrosum 10-50 part, Radix Glycyrrhizae 1-20 part, Ramulus et Folium Gmelinae leaves 3-5 part; Preparation method is that aqua armeniacae is produced in the Semen Armeniacae Amarum distillation that adds water, and medicinal residues and all the other four Chinese medicine materials decoct with water, filter, hold over night, get supernatant concentrating under reduced pressure and become clear paste, add sucrose and sodium benzoate, boil and make dissolving, filter, let cool, add above-mentioned aqua armeniacae, add water to quantitatively, stir evenly, get product.
3. described in claim 1 based on a preparation method for the antitussive and antiasthmatic medicine of Ramulus et Folium Gmelinae, it is characterized in that, the weight portion of each raw medicinal material of soft extract is: Herba Ephedrae 5-30 part, Semen Armeniacae Amarum 5-30 part, Gypsum Fibrosum 10-50 part, Radix Glycyrrhizae 1-20 part, Ramulus et Folium Gmelinae leaves 3-5 part; Preparation method is Herba Ephedrae, Semen Armeniacae Amarum adds water, and distillate is produced in distillation, and medicinal residues and all the other samadhi medical materials decoct with water, filter, hold over night, get supernatant concentrating under reduced pressure and become thick paste; Separately get sucrose and make syrup, add above-mentioned thick paste and refined honey, be concentrated into appropriate, let cool, add above-mentioned distillate, stir evenly, subpackage, packaging gets product.
4. described in claim 1 based on a preparation method for the antitussive and antiasthmatic medicine of Ramulus et Folium Gmelinae, it is characterized in that, the weight portion of each raw medicinal material of mixture is: Herba Ephedrae 5-30 part, Semen Armeniacae Amarum 5-30 part, Gypsum Fibrosum 10-50 part, Radix Glycyrrhizae 1-20 part, Ramulus et Folium Gmelinae leaves 3-5 part; Preparation method is Herba Ephedrae, Semen Armeniacae Amarum adds water, and distillate is produced in distillation, and medicinal residues and its excess-three taste medical material decoct with water, and filters, hold over night, get supernatant concentrating under reduced pressure and become thick paste, add sucrose and sodium benzoate, boil and make dissolving, filter, let cool, add above-mentioned aqua armeniacae, add water to quantitatively, stir evenly, to obtain final product.
5. described in claim 1 based on a preparation method for the antitussive and antiasthmatic medicine of Ramulus et Folium Gmelinae, it is characterized in that, each raw medicinal material weight portion of tablet is: Herba Ephedrae 5-30 part, Semen Armeniacae Amarum 5-30 part, Gypsum Fibrosum 10-50 part, Radix Glycyrrhizae 1-20 part, Ramulus et Folium Gmelinae leaves 3-5 part; Making each technique is that gomi herbs decocts with water, and filter, hold over night, gets supernatant concentrating under reduced pressure and become thick paste, drying and crushing, granulates, tabletting.
6. described in claim 1 based on a preparation method for the antitussive and antiasthmatic medicine of Ramulus et Folium Gmelinae, it is characterized in that, the weight portion of each raw medicinal material of capsule is: Herba Ephedrae 5-30 part, Semen Armeniacae Amarum 5-30 part, Gypsum Fibrosum 10-50 part, Radix Glycyrrhizae 1-20 part, Ramulus et Folium Gmelinae leaves 3-5 part; Preparation method is that aqua armeniacae is produced in the Semen Armeniacae Amarum distillation that adds water, and medicinal residues and all the other four Chinese medicine materials decoct with water, filter, hold over night, get supernatant concentrating under reduced pressure and become clear paste, add sucrose and sodium benzoate, boil and make dissolving, filter, let cool, add above-mentioned aqua armeniacae, add water to quantitatively, stir evenly, get product.
7. the preparation method of the antitussive and antiasthmatic medicine based on Ramulus et Folium Gmelinae according to claim 2,3,4,5 or 6, is characterized in that, the preparation method of described Ramulus et Folium Gmelinae leaves is: de-stone Catalpa ovata Don. leaf, dry, be ground into powder.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108175743A (en) * | 2018-01-19 | 2018-06-19 | 山东迅达康兽药有限公司 | A kind of preparation method of Maxingshigan oral liquid |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1724019A (en) * | 2005-07-04 | 2006-01-25 | 陈学锋 | Medicine for relieving-cough and asthma |
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2014
- 2014-12-11 CN CN201410754696.7A patent/CN104491198A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1724019A (en) * | 2005-07-04 | 2006-01-25 | 陈学锋 | Medicine for relieving-cough and asthma |
Non-Patent Citations (1)
| Title |
|---|
| 张启云: "麻杏石甘汤对哮喘豚鼠的血浆代谢组学研究", 《中药药理与临床》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108175743A (en) * | 2018-01-19 | 2018-06-19 | 山东迅达康兽药有限公司 | A kind of preparation method of Maxingshigan oral liquid |
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