CN101040950B - Method of preparing compound Houttuynia cordata dropping pills - Google Patents
Method of preparing compound Houttuynia cordata dropping pills Download PDFInfo
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- CN101040950B CN101040950B CN2007100521140A CN200710052114A CN101040950B CN 101040950 B CN101040950 B CN 101040950B CN 2007100521140 A CN2007100521140 A CN 2007100521140A CN 200710052114 A CN200710052114 A CN 200710052114A CN 101040950 B CN101040950 B CN 101040950B
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Abstract
The invention discloses a process for preparing compound houttuynia cordata dripping pill, wherein the raw materials include cordate houttuynia, baikal skullcap root, isatic root, capsule of weeping forsythia and honeysuckle flower. The preparing process comprises steps of extracting volatile oil, extracting the medicinal slag with water, filtering the extract, concentrating, alcohol depositing, concentrating the supernatant fluid into fluid extract, charging volatile oil, mixing homogenously, and charging into auxiliary matrix.
Description
Technical field
The invention belongs to field of Chinese herbal, refer more particularly to a kind of treat affection due to external wind and heat cause have sore throat, the method for preparing of acute pharyngitis, tonsillitic FUFANG YUXINGCAO DIWAN.
Background technology
Pharyngitis, tonsillitis are the common symptoms of upper respiratory tract infection, and the traditional Chinese medical science belongs to throat moth, the sore throat category of larynx section, is that affection due to external wind and heat causes.Doctor trained in Western medicine thinks that then pharyngitis, tonsillitis are pharyngolaryngeal mucosa and adenoid inflammation thereof, and the cause of disease mainly is stimulations such as antibacterial, viral infection, chemical factors dust, tobacco and wine; Also can be secondary to the symptom in early stage of systemic disease or other diseases, treatment adopts antibiotics to be aided with methods such as buccal tablets agent mostly, but curative effect is often undesirable; Though having, symptom alleviates; But the swelling and ache of throat, dried disease such as itch often delay difficult more, be difficult for eradicating, the several months that has does not heal, thereby has caused the antibiotic abuse.
The way that traditional Chinese medical science utilization organic conception and dialectical opinion control that external wind heat causes has sore throat, acute pharyngitis, tonsillitis often adopt heat-clearing and toxic substances removing.FUFANG YUXINGCAO DIWAN of the present invention has adopted Herba Houttuyniae, Radix Scutellariae, Radix Isatidis, Fructus Forsythiae, Flos Lonicerae five kinds of Chinese medicine, reaches pharynx-clearing throat-benefiting, toxic and side effects effect little, that do not show effect repeatedly through synergism.
Herba Houttuyniae property is hot, is slightly cold, and returns lung meridian, has heat-clearing and toxic substances removing, an effect of the pain that disappears evacuation of pus, inducing diuresis for treating stranguria syndrome, is monarch drug.Modern pharmacological research shows, that Herba Houttuyniae has is antibiotic, antiviral, immunomodulating, diuresis.The clinical report that has 24 kinds of active chronic inflammations of its treatment 109 examples proves that it has definite curative effect.
Radix Scutellariae property is bitter, and is cold, returns lung, gallbladder, spleen, large intestine, small intestine meridian, has heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive effect, is ministerial drug.The pharmacology report: it has antimicrobial effect, antiinflammatory and anti-allergy action.The low dosage baicalin can obviously promote the inductive mice spleen lymphocytes proliferation reaction of con A (ConA); High dose then significantly suppresses, and brings high blood pressure down with diuresis, effect for reducing blood fat, the gathering of anti-blood plate and anticoagulation, antioxidation, the central nervous system is had remarkable sedation.Clinical report treatment children's acute respiratory tract infection 51 examples, anxious chronic bronchitis tracheitis 11 examples, acute tonsillitis 1 example are controlled back body temperature and are reduced to normally transference cure person 51 examples, invalid 12 examples.
Radix Isatidis property is bitter, cold, and GUIXIN, stomach warp have the effect of heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving.The pharmacology report, Radix Isatidis has antibacterium, antiviral effect, and anti-endotoxin effect, antitumaous effect have regulating action to immunity; Clinically be used to treat child virus upper respiratory tract infection, injection 182 examples, produce effects 60 examples, effective 12 examples; Granule 50 examples, produce effects 20 examples, effective 16 examples.
Fructus Forsythiae property is bitter, is slightly cold, and returns lung, the heart, small intestine meridian.Effect with heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Pharmacological research shows that Fructus Forsythiae is the effective antimicrobial medicine of a kind of wide spectrum, and in vitro tests has inhibitory action to many kinds of antibacterials.
The Chinese medicine of the clinical acute tonsillitis that is used for heat-clearing and toxic substances removing, pharyngitis, chronic bronchitis is more, is many with the Chinese medicine agent.At present, similar FUFANG YUXINGCAO PIAN, capsule are arranged on the market, not only production technology falls behind, and active constituent content is low, the quality standard imperfection, and also disintegrate is slow, and release is slow, and bioavailability is low, and curative effect has much room for improvement.
Summary of the invention
The method for preparing that the purpose of this invention is to provide a kind of FUFANG YUXINGCAO DIWAN; The FUFANG YUXINGCAO DIWAN of this method preparation is a quick-effective preparation; Its substrate can not only medicine carrying with give the drop pill shape, and can utilize solid dispersion technology and its macromolecular material self-characteristic to increase the TDS and the dissolution of medicine, the performance drug effect is rapid; Bioavailability is high, is welcome dosage form on the market.The inventor is improving technology, is analyzing dissolution, the standard that improves the quality, accomplishing on the basis of pharmacology pharmacodynamic comparison and accomplished the present invention.
The present invention realizes like this, is crude drug with Herba Houttuyniae, Radix Scutellariae, Radix Isatidis, Fructus Forsythiae, Flos Lonicerae, prepares according to following steps.
1, Herba Houttuyniae, Radix Isatidis, Fructus Forsythiae, Flos Lonicerae are mixed or extract volatile oil separately;
2, above-mentioned four Chinese medicine pulp water is carried 2-3 time, and each 0.5-2 hour, predefecation was handled, and is concentrated into that in the time of 60 ℃, to survey relative density about 1.05～1.30, adds ethanol and makes and contain the alcohol amount and reach 55%-85%, filters, and reclaims ethanol and also is condensed into fluid extract;
3, Radix Scutellariae water is carried secondary, adds the water that 10-12 doubly measures at every turn, and each 0.5-3 hour, the water extract suitably concentrated; Transfer pH value to 1.0-3.0,60 ℃-95 ℃ are incubated 0.5-2.5 hour, left standstill 12-48 hour; Filter, precipitate is washed with the ethanol of 30%-99%, and reuse is washed to PH4～7; Cold drying is pulverized, and gets the Radix Scutellariae extract powder;
4, the Radix Scutellariae extract powder is joined in the above-mentioned fluid extract, add volatile oil, mixing joins in the adjuvant, and mixing drips and processes ball.
The percentage by weight of above crude drug is:
Herba Houttuyniae 20%-78% Radix Scutellariae 8%-25% Radix Isatidis 8%-25%
Fructus Forsythiae 1%-10% Flos Lonicerae 1%-10%
Above crude drug percentage by weight is preferred:
Herba Houttuyniae 40%-70% Radix Scutellariae 10%-20% Radix Isatidis 10%-20%
Fructus Forsythiae 3%-10% Flos Lonicerae 3%-10%
Preferred version is a Herba Houttuyniae 58.4%, Radix Scutellariae 15%, Radix Isatidis 15%, Fructus Forsythiae 5.8%, Flos Lonicerae 5.8%.
Get Herba Houttuyniae, Radix Isatidis, Fructus Forsythiae, Flos Lonicerae, the water logging that adds 12 times of amounts was steeped 2-5 hour, distillation, and volatile oil device is in addition preserved, and is subsequent use; Medicinal residues filter, and filtrating [I] is deposited in addition; Medicinal residues add the water that 10-12 doubly measures to be continued to decoct 2-3 time, and 1-2 hour at every turn, collecting decoction; Filter, merge, be concentrated into and in the time of 60 ℃, survey relative density about 1.15 with filtrating [I]; Put coldly, add ethanol and make and contain alcohol amount and reach 70%, placed 24 hours; Filter, filtrate recycling ethanol also continues to be condensed into fluid extract, and is subsequent use; Get Radix Scutellariae, add the decocting that 10-12 doubly measures and boil secondary, each 0.5-3 hour, filter, merging filtrate is regulated pH value 1-3 with hydrochloric acid; 60 ℃-95 ℃ are incubated 1 hour, leave standstill 24 hours, filter, and deposition is washed with ethanol, and reuse is washed to PH4-7; The decompression cold drying is pulverized, and gets the Radix Scutellariae extract powder, joins in the above-mentioned fluid extract, adds volatile oil; Mixing is got the PEG-6000 fusion, and medicine is joined in the fused solution substrate, and medicine and substrate composition 1: 2-5 is advisable, preferred 1: 3.In following system of 65 ℃ of-90 ℃ of keeping warm modes, be condensing agent with liquid Paraffin or dimethicone, chilling temperature-5 ℃-0 ℃ is collected drop pill, and wiping promptly gets.
Can use supercritical extraction, water vapour distillation at the volatile oil of extraction described in the step.
Supernatant behind described water extract filtration and the precipitate with ethanol filters the available membrane separation technique of filter, common plate-and-frame filtration device carries out.
Described Radix Scutellariae water extract is regulated PH to 1.0-3.0 with acid, can be mineral acids such as hydrochloric acid, nitric acid, sulphuric acid, phosphoric acid, and alcohol is washed the ethanol that precipitate can be used 30%-99%.
The used adjuvant of described drop pill is to gather ethanol class, sodium stearate, poloxamer separately or mix and use.
Advantage of the present invention is: have the effect of heat-clearing and toxic substances removing, be used for that affection due to external wind and heat causes have sore throat, acute pharyngitis, tonsillitis.Clinically to upper respiratory tract infection, acute tonsillitis, pharyngitis, periodontitis, chronic bronchitis, lung abscess, inguinal bubo etc.
The specific embodiment
Embodiment 1
Fish raw meat leather 1100g Radix Scutellariae 333g Radix Isatidis 333g
Fructus Forsythiae 116g Flos Lonicerae 116g
Get water logging bubble 2-5 hour that Herba Houttuyniae, Radix Isatidis, Fructus Forsythiae, Flos Lonicerae add 12 times of amounts, use water vapour distillation, volatile oil device preservation in addition, subsequent use; Medicinal residues filter, and filtrating [I] is deposited in addition; Medicinal residues add the water that 10-12 doubly measures to be continued to decoct 2 times, and each 1 hour, collecting decoction; Filter, merge, be concentrated into and in the time of 60 ℃, survey relative density about 1.15 with filtrating [I]; Put coldly, add ethanol and make and contain alcohol amount and reach 70%, placed 24 hours; Filter, filtrate recycling ethanol also continues to be condensed into fluid extract, and is subsequent use; Get Radix Scutellariae, add the decocting that 10-12 doubly measures and boil secondary, each 2 hours, filter merging filtrate; Suitably concentrate, regulate pH value 1-2 with hydrochloric acid, 80 ℃ are incubated 1 hour, leave standstill 24 hours, filter; Deposition is washed with 90% ethanol, and reuse is washed to PH5-6, and the decompression cold drying is pulverized; Get the Radix Scutellariae extract powder, join in the above-mentioned fluid extract, add volatile oil, mixing; Get the PEG-6000 fusion, medicine is joined in the fused solution substrate, medicine and substrate composition 1: 2-4 is advisable, preferred 1: 3.In following system of 65 ℃ of-90 ℃ of keeping warm modes, be condensing agent with the dimethicone, chilling temperature-4 ℃ is collected drop pill, and wiping promptly gets.
Embodiment 2
Herba Houttuyniae 1166g Radix Scutellariae 290g Radix Isatidis 290g
Fructus Forsythiae 126g Flos Lonicerae 126g
Get the water logging bubble 4 hours that Herba Houttuyniae, Radix Isatidis, Fructus Forsythiae, Flos Lonicerae add 12 times of amounts, use water vapour distillation, volatile oil device preservation in addition, subsequent use; Medicinal residues filter, and filtrating [I] is deposited in addition; Medicinal residues add the water that 10-12 doubly measures to be continued to decoct 2 times, and each 1.5 hours, collecting decoction; Filter, merge, be concentrated into and in the time of 60 ℃, survey relative density about 1.15 with filtrating [I]; Put coldly, add ethanol and make and contain alcohol amount and reach 70%, placed 24 hours; Filter, filtrate recycling ethanol also continues to be condensed into fluid extract, and is subsequent use; Get Radix Scutellariae, add the decocting that 10-12 doubly measures and boil secondary, each 0.5-3 hour, filter, merging filtrate is concentrated into medical material 15 amounts; Regulate pH value about 2 with sulphuric acid, 90 ℃ are incubated 1 hour, leave standstill 36 hours, filter, and deposition is washed with 70% ethanol, and reuse is washed to PH5-6; The decompression cold drying is pulverized, and gets the Radix Scutellariae extract powder, joins in the above-mentioned fluid extract, adds volatile oil; Mixing is got the sodium stearate fusion, and medicine is joined in the fused solution substrate, and medicine and substrate composition are advisable at 1: 3, in following system of 75 ℃ of keeping warm modes; With the liquid Paraffin is condensing agent, and chilling temperature-5 ℃ is collected drop pill, and wiping promptly gets.
Claims (4)
1. the method for preparing of a FUFANG YUXINGCAO DIWAN; Process by the following materials medicine: Herba Houttuyniae 20%-78%, Radix Scutellariae 8%-25%, Radix Isatidis 8%-25%, Fructus Forsythiae 1%-10%, Flos Lonicerae 1%-10%; Herba Houttuyniae, Radix Isatidis, Fructus Forsythiae, Flos Lonicerae are mixed or extract volatile oil separately; Collect volatile oil, subsequent use;
It is characterized in that:
(1) above-mentioned four Chinese medicine pulp water is carried, and filters, and filtrating is concentrated into and in the time of 60 ℃, surveys relative density is 1.05～1.30, adds ethanol, makes to contain the alcohol amount and reach 55%-85%, filters, and reclaims ethanol, processes fluid extract;
(2) Radix Scutellariae water is carried, and the water extract is transferred ℃ of-95 ℃ insulations in PH to 1.0～3.0,60 0.5-2.5 hour, leaves standstill 12-48 hour, filters, and deposition is washed, washed to PH4-7 with 30%-99% ethanol, and cold drying is pulverized, and gets the Radix Scutellariae extract powder;
(3) the Radix Scutellariae extract powder is joined in the fluid extract, add volatile oil, mixing joins in the adjuvant, and mixing is processed drop pill.
2. method for preparing according to claim 1 is characterized in that described crude drug percentage by weight is: Herba Houttuyniae 40%-70%, Radix Scutellariae 10%-20%, Radix Isatidis 10%-20%, Fructus Forsythiae 3%-8%, Flos Lonicerae 3%-8%.
3. according to the described method for preparing of claim 1-2, it is characterized in that described extraction volatile oil is with supercritical extraction, water vapour distillation.
4. according to the described method for preparing of claim 1-2, it is characterized in that the used adjuvant of described drop pill is polyethylene glycols, sodium stearate, poloxamer is independent or mix use.
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| CN2007100521140A CN101040950B (en) | 2007-04-29 | 2007-04-29 | Method of preparing compound Houttuynia cordata dropping pills |
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| CN101040950B true CN101040950B (en) | 2012-02-22 |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101683182B (en) * | 2008-09-27 | 2012-07-04 | 湖北中烟工业有限责任公司 | Heartleaf houttuynia herb and radix isatidis compound extract and application thereof as additive of tobacco product |
| CN102018810B (en) * | 2010-12-09 | 2012-01-11 | 浙江惠松制药有限公司 | Preparation method of compound Houttuynia cordata mixture |
| CN103494928B (en) * | 2013-09-29 | 2014-12-31 | 江西天施康中药股份有限公司 | Preparation method for compound houttuynia cordata preparation |
| CN103520227A (en) * | 2013-10-09 | 2014-01-22 | 南京农业大学 | Injectable Isatis Root in-situ gel, and preparation method thereof |
| CN104435113B (en) * | 2014-12-16 | 2018-06-19 | 江西天施康中药股份有限公司 | It is used to prepare the preparation method of the Baical Skullcap root P.E of Ynxingchao dropping pills compound |
| CN107474963A (en) * | 2017-09-01 | 2017-12-15 | 云南巴菰生物科技有限公司 | A kind of cordate houttuynia essential oil cigarette is with quick-fried pearl and preparation method thereof |
| CN109481527B (en) * | 2017-09-11 | 2021-11-16 | 石家庄以岭药业股份有限公司 | Traditional Chinese medicine composition for preventing or treating oral diseases and application thereof |
| CN109012185A (en) * | 2018-08-23 | 2018-12-18 | 河北维尔利动物药业集团有限公司 | Membrane separation technique takes orally the application in liquid preparing process in cordate houttuynia a kind of reed mentioned in ancient books indigo plant |
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| CN1548104A (en) * | 2003-05-24 | 2004-11-24 | 毛友昌 | Compound cordate bouttuynia bolus and its prepn |
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Patent Citations (1)
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|---|---|---|---|---|
| CN1548104A (en) * | 2003-05-24 | 2004-11-24 | 毛友昌 | Compound cordate bouttuynia bolus and its prepn |
Non-Patent Citations (2)
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| 徐发红等.复方鱼腥草滴丸成型工艺研究.《药品评价》.2006,3(6),431-433. * |
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Address after: 335200 north of national highway 320, Jiaotong North Road, Yujiang District, Yingtan City, Jiangxi Province Patentee after: Jiangxi Kangenbei tianshikang Pharmaceutical Co.,Ltd. Address before: 21 Jianshe Road, Yingtan City, Jiangxi Province Patentee before: Jiangxi Herbi-Sky Co.,Ltd. |
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