CN106963833B - Medicine for treating cold of children and adults and preparation method thereof - Google Patents
Medicine for treating cold of children and adults and preparation method thereof Download PDFInfo
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- CN106963833B CN106963833B CN201710377085.9A CN201710377085A CN106963833B CN 106963833 B CN106963833 B CN 106963833B CN 201710377085 A CN201710377085 A CN 201710377085A CN 106963833 B CN106963833 B CN 106963833B
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a medicament for the treatment of children and adult's cold and its preparation method, this medicament is with semen Armeniacae dulcis, hyssop, hollyhock, arabic gum, flos nymphae and licorice extract as raw materials, put hyssop into extractor, water extract volatile oil, filter aqueous solution after distilling for subsequent use, collect volatile oil for subsequent use, or include volatile oil collected with beta-cyclodextrin, for subsequent use; decocting the dregs of a decoction, the three medicinal materials of the almond, the hollyhock and the nymphaea tetragona in water, merging decoction, filtering, merging filtrate and the aqueous solution after distillation and filtration, concentrating, cooling to room temperature, adding ethanol, stirring uniformly, standing, filtering, pressurizing the filtrate, recovering the ethanol, concentrating to a proper amount, adding crushed Arabic gum and licorice extract, adding volatile oil or beta-cyclodextrin inclusion compound of the volatile oil, and preparing the granules according to a conventional pharmaceutical method.
Description
Technical Field
The invention relates to a medicament for treating children and adults cold and a preparation method thereof, in particular to a Chinese patent medicament (Uygur medicament) prepared by taking Chinese herbal medicines as raw materials, which is used for treating children and adults cold and influenza.
Background
The cold is classified into narrow sense and broad sense, which refers to common cold and is a slight viral infection of upper respiratory tract (nose and throat). Influenza is also included in the broad sense and is generally more severe than the common cold, with additional symptoms including fever, chills and muscle soreness, and with more pronounced systemic symptoms.
Common cold, also called acute nasopharyngitis, called cold for short, is the most common disease in acute upper respiratory virus infection in traditional Chinese medicine, is mostly self-limiting, but has high incidence, affects a wide range of people, has large amount and huge economic loss, and can cause various complications.
The pathogens of the cold are viruses, common people comprise rhinovirus, coronavirus and parainfluenza virus, rare people comprise respiratory syncytial virus, adenovirus, enterovirus and the like, and even coxsackie virus, echovirus, reovirus types 1-3, herpes simplex virus type 1, EB virus and the like in the enterovirus can be used as the pathogens of the cold. It is often associated with bacterial infection, mainly manifested as inflammation of nasopharynx, and can cause various complications. The mycoplasma pneumoniae, group A, C and G streptococcus and non-biological pathogenic factors such as allergic rhinitis, atrophic rhinitis, vasomotor rhinitis, nasal septum deflection, foreign bodies and the like can cause cold-like symptoms, and are not cold in the true sense.
The incubation period varies from 1 to 3 days, and varies with the virus, the enterovirus is the shortest, and the adenovirus and the respiratory syncytial virus are longer. The onset is sudden. Most of them are a burning sensation in the nose and throat, followed by nasal obstruction, sneezing, nasal discharge, general malaise and muscular soreness. Symptoms peak at 48h (virus uncoating) and acute nasopharyngitis is usually not or only low-grade fever, especially with rhinovirus or coronavirus infections. There are conjunctival congestion, lacrimation, photophobia, eyelid swelling, and edema of throat mucosa. The presence or absence of laryngopharyngitis and tracheitis varies from human to human and from viruses. Nasal secretions initially take the form of a large number of watery thin nasal discharges and later become mucous or purulent. Purulent secretions do not necessarily indicate a secondary bacterial infection. Coughing is usually not severe and can last as long as 2 weeks. Purulent sputum or severe lower respiratory symptoms suggest viral complications other than rhinovirus or secondary bacterial infection. When children catch cold, the symptoms are more serious than adults, and the symptoms of the lower respiratory tract and the digestive tract (vomiting, diarrhea and the like) are frequent. The cold is self-limited, if there is no complication, the course of disease is 4-10 days.
Influenza, an acute respiratory infectious disease caused by influenza virus, can cause various complications such as myocarditis, pneumonia, bronchitis and the like. It is usually manifested as malaise, chills, fever, body temperature rise to 39 deg.C or above, headache, general soreness, fatigue, pharyngalgia, paranoia, and rhinorrhea. Epidemiologically, the traditional Chinese medicine has the characteristics of high morbidity, quick onset, quick transmission, wide epidemiology, great variability, strong infectivity and certain mortality (mainly infants, the elderly, the weak, and patients with immune or cardiopulmonary insufficiency). The symptoms of a high-incidence influenza population of school-age children are often more serious than those of adults, and the symptoms of the lower respiratory tract and the symptoms of the digestive tract (such as vomiting and diarrhea) are frequent. Influenza viruses are classified into three types, i.e., influenza a, influenza b and influenza c, and infections caused by influenza a are common. Influenza is often caused by seasonal outbreaks, as influenza viruses are occasionally derived from new species.
Influenza epidemics often cause more serious social impact, and estimated according to data published by the world health organization, the worldwide annual number of influenza cases reaches 6-12 hundred million. China is a place with a lot of flu, the disease is tens of millions every year, and a flu activity peak is generated in the north of China every year in winter.
Uygur medicine is an integral part of Chinese medicine and pharmacy, has over 2500 years of history so far, and is an important part of Chinese traditional medicine and Uygur excellent traditional culture. Uygur medicine integrates the advantages of Arabic and ancient Greece medicine, is also harmoniously developed with traditional Chinese medicine, is a practical experience accumulated by Uygur people in disease prevention and treatment for thousands of years, gradually forms a theoretical system with unique Uygur cultural characteristics and rich clinical experience, and exerts miraculous effect in clinic.
The compound almond granules are patent medicine preparations recorded in the drug Standard-Uighur medicine Manual of the Ministry of public health of the people's republic of China, are the traditional classic famous prescription for Uygur medicine to treat upper respiratory tract infection and cold, are prepared from 6 medicinal materials of almond, fenugreek seed, hollyhock seed, arabic gum, tragacanth and licorice extract, and have the effects of relieving cough and reducing sputum and promoting sleep. The traditional Chinese medicine composition has the effects of treating cold cough, cold with excessive phlegm, asthma and insomnia, and has definite and reliable curative effect and convenient taking through years of clinical use. However, due to the fact that the cucurbit seed and the tragacanth in the prescription lack of the legal medicinal material quality standard, the effective control of the product quality of the preparation is certain obstacle, aiming at the defect of the preparation, the prescription of 'compound almond granules' is modified, the new prescription consists of almond, hyssop, hollyhock, arabic gum, water lily flower and licorice extract, the medicine effect and toxicity test research of the new prescription is carried out, and the results show that: the medicine can obviously reduce the cough frequency of mice and the body temperature of febrile rats.
Disclosure of Invention
The invention aims to provide a medicament for treating children and adult cold and a preparation method thereof, the medicament takes almond, hyssop, hollyhock, arabic gum, water lily flower and licorice extract as raw materials, the hyssop is placed in an extractor, water is added to extract volatile oil, distilled water solution is filtered for standby, the volatile oil is collected for standby, or the collected volatile oil is included by beta-cyclodextrin for standby; decocting the dregs of a decoction, the three medicinal materials of the almond, the hollyhock and the water lily flower in water, merging decoction, filtering, merging filtrate and the water solution after distillation and filtration, concentrating, cooling to room temperature, adding ethanol, stirring uniformly, standing, filtering, pressurizing the filtrate, recovering the ethanol, concentrating to a proper amount, adding the crushed Arabic gum and the licorice extract, adding the volatile oil or the beta-cyclodextrin inclusion compound of the volatile oil, and preparing the granules according to a conventional pharmaceutical method.
The medicine for treating cold of children and adults is prepared from 4-8 parts of almond, 4-8 parts of hyssop, 8-12 parts of hollyhock, 0.5-2 parts of Arabic gum, 4-8 parts of water lily flower and 6-10 parts of licorice extract by taking 20g as a base number.
The preparation method of the medicine for treating the cold of the children and the adults takes 20g as a base number and comprises the following steps:
a. placing 4-8 parts of hyssop into an extraction container, adding 6-12 times of water, extracting volatile oil for 4-8 hours, filtering the distilled water solution for later use, collecting the volatile oil, dissolving the collected volatile oil into ethanol solution containing 30-70% of the volatile oil by using 95% ethanol, or clathrating the collected volatile oil with 3-7g of beta-cyclodextrin according to a conventional pharmaceutical method for later use;
b. b, decocting the medicine residues, 4-8 parts of almond, 8-12 parts of hollyhock and 4-8 parts of water in an amount which is 6-12 times that of water for 1-3 times, 0.5-2 hours each time, combining the decoction, filtering, combining the filtrate with the water solution obtained after distillation and filtration in the step a, concentrating until the relative density is 0.9-1.2, cooling to room temperature, adding ethanol with the volume ratio concentration of 95% to ensure that the alcohol content is 30-75% by volume, stirring uniformly, refining for 24 hours, filtering, recovering the ethanol from the filtrate under reduced pressure, and concentrating to obtain thick paste;
c. pulverizing 0.5-2 parts of Arabic gum and 6-10 parts of licorice extract into fine powder, adding the fine powder into the thick paste obtained in the step b, uniformly mixing, mixing the volatile oil beta-cyclodextrin inclusion compound obtained in the step a with pharmaceutically acceptable auxiliary materials of sucrose powder and starch, adding the mixture into the thick paste, drying at the temperature of 60 ℃, cooling, and preparing the granular medicine for treating the cold of children and adults by a conventional pharmaceutical method;
or crushing 1.5 parts of Arabic gum and 7 parts of licorice extract into fine powder, adding the fine powder into the thick paste obtained in the step b, uniformly mixing, adding sucrose powder and starch, uniformly mixing, preparing granules according to a conventional pharmaceutical method, drying at the temperature of 60 ℃, cooling, dissolving the volatile oil obtained in the step a by using ethanol with the volume concentration of 95% to prepare an ethanol solution containing 30% -70% of the volatile oil, spraying the ethanol solution into the granules, and uniformly mixing to obtain the granular medicine for treating the cold of children and adults.
The invention relates to a medicament for treating children and adult cold and process for preparation, wherein the volatile oil in the step a is prepared through the steps of: coating each 1mL of volatile oil with 3-7g of beta-cyclodextrin, stirring at 20 ℃ for 0.5-1.5 hours, refrigerating overnight, filtering, drying at 40 ℃ for 4-8 hours, grinding, and sieving with a 100-mesh sieve to obtain the volatile oil beta-cyclodextrin inclusion compound.
The invention relates to a medicament for treating cold of children and adults and a preparation method thereof, wherein the pharmacological properties of the raw materials in the medicament are as follows:
and (3) almond: is dried mature seed of Rosaceae plant sweet Badan Amygdalus communis L. The product has effects in protecting nutrition, strengthening body constitution, strengthening brain, improving eyesight, caring skin, moistening intestine, and relieving cough. Can be used for treating asthenia, cough, excessive phlegm, chest distress, constipation, and dim eyesight.
Hyssop: is dried aerial parts of Hyssopus cuspidus Boris of Labiatae. The product has effects of promoting maturation, eliminating abnormal mucus, promoting natural coordination, relieving cough, eliminating phlegm, relieving asthma, and benefiting lung. Can be used for treating persistent and stubborn diseases of chest and lung, headache, chest pain, asthma, short breath, pain in chest and hypochondrium, chronic cough, and excessive phlegm.
Hollyhock seed: is dried mature fruit of Althaea rosea (L.) Cavan belonging to Malvaceae. The product has effects in promoting the generation of dampness and cold, relieving cough, relieving inflammation and pain, clearing intestine, eliminating ulcer, promoting urination, and removing calculus. Can be used for treating dry heat or biliary diseases, headache, brain heat, cough due to dry heat, intestinal ulcer, and bladder and kidney calculus.
Gum arabic: dried gum is collected from Acacia senegal willd, a leguminous plant and other plants of the genus Acacia and exuded and coagulated into tear drops, and impurities are removed. The product has the effects of relieving sore throat, stopping the emergence of Nezilei, harmonizing purgative, reducing phlegm and relieving chest stuffiness. Clearing away abnormal gallbladder function. Can be used for treating sore throat, hoarseness, cough, expectoration, chest pain, and tracheitis.
Water lily flower: is dried flower bud of Nymphaea candida presl. The product has effects of lowering heat, relieving cough, benefiting heart, protecting brain, tranquilizing mind, relieving pain, and eliminating Nezi. Can be used for treating common cold, fever, headache, cough, palpitation, uneasiness, pharyngalgia, and toxic substance removal.
And (3) liquorice extractum: the product is prepared from Glycyrrhrizae radix. (the product is the dried root and rhizome of Glycyrrhiza uralensis Fisch., glycyrrhiza inflata Bat. Or Glycyrrhiza glabra L. Of Leguminosae, and has the effects of invigorating spleen and replenishing qi, clearing away heat and toxic materials, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the drugs.
The invention relates to a medicament for treating cold of children and adults and a preparation method thereof, which are researched by pharmacodynamic and toxicological tests: the medicine can obviously reduce the cough frequency of mice and the body temperature of febrile rats.
Detailed Description
Example 1 (base of 20 g)
a. Placing 4 parts of hyssop into an extraction container, adding 6 times of water, extracting volatile oil for 4 hours, filtering the distilled water solution for later use, collecting the volatile oil, and dissolving the collected volatile oil with 95% ethanol by volume concentration to prepare 30% ethanol solution containing the volatile oil for later use;
b. b, adding 6 times of water into the medicine residues, 8 parts of almond, 12 parts of hollyhock and 8 parts of water lily, decocting for 1 time for 2 hours, filtering, combining the filtrate with the water solution obtained after distillation and filtration in the step a, concentrating to a solution with the relative density of 0.9-1.2 (measured at 50 ℃), cooling to room temperature, adding ethanol with the volume ratio concentration of 95% to ensure that the alcohol content reaches 30-75% of the volume ratio, stirring uniformly, standing for 24 hours, filtering, recovering ethanol from the filtrate under reduced pressure, concentrating to prepare thick paste, and measuring the relative density at 70 ℃ to be 1.3-1.4;
c. and (b) crushing 2 parts of Arabic gum and 10 parts of licorice extract into fine powder, adding the fine powder into the thick paste obtained in the step (b), uniformly mixing, adding sucrose powder (80 meshes) and starch, uniformly mixing, granulating (14 meshes) by a conventional method, drying at the temperature of 60 ℃, cooling, dissolving the volatile oil obtained in the step (a) by using ethanol with the volume concentration of 95% to prepare an ethanol solution containing 30% of the volatile oil, spraying the ethanol solution into granules, and uniformly mixing to obtain the granular medicine for treating the cold of children and adults.
Example 2 (base of 20 g)
a. Putting 8 parts of hyssop officinalis in an extraction container, adding 12 times of water to extract volatile oil for 8 hours, filtering distilled water solution for later use, collecting the volatile oil, including each 1mL of the volatile oil with 3g of beta-cyclodextrin, stirring at 20 ℃ for 0.5 hour, refrigerating overnight, performing suction filtration, drying at 40 ℃ for 4 hours, grinding, and sieving with a 100-mesh sieve to obtain a beta-cyclodextrin inclusion compound of the volatile oil for later use;
b. b, adding 12 times of water into the medicine residues, 4 parts of almond, 8 parts of hollyhock and 4 parts of water lily, decocting for 3 times, each time lasting for 0.5 hour, combining the decoction, filtering, combining the filtrate with the water solution obtained after distillation and filtration in the step a, concentrating until the relative density is 0.9-1.2, cooling to room temperature, adding 95% ethanol by volume to ensure that the alcohol content is 30-75% by volume, stirring uniformly, standing for 24 hours, filtering, recovering ethanol from the filtrate under reduced pressure, concentrating to prepare thick paste, and measuring the relative density at 70 ℃ to be 1.3-1.4;
c. and (b) crushing 0.5 part of Arabic gum and 6 parts of licorice extract into fine powder, adding the fine powder into the thick paste, uniformly mixing, adding sucrose powder (80 meshes), starch and the beta-cyclodextrin inclusion compound of the volatile oil obtained in the step (a), uniformly mixing, granulating (14 meshes), drying at the temperature of 60 ℃, cooling, and preparing the granules for treating the cold of children and adults by a conventional pharmaceutical method.
Example 3 (base of 20 g)
a. Placing 6 parts of hyssop into an extraction container, adding 8 times of water, extracting volatile oil for 5 hours, filtering the distilled water solution for later use, collecting the volatile oil, and dissolving the collected volatile oil with 95 volume percent ethanol to prepare 70 percent ethanol solution containing the volatile oil for later use;
b. b, adding 8 times of water into the medicine residues, 5 parts of almond, 10 parts of hollyhock and 6 parts of water lily, decocting for 2 times, wherein each time is 1 hour, filtering, combining the filtrate with the water solution obtained after distillation and filtration in the step a, concentrating to a solution with the relative density of 0.9-1.2 (measured at the temperature of 50 ℃), cooling to room temperature, adding ethanol with the volume concentration of 95% to ensure that the alcohol content reaches 30-75% of the volume ratio, stirring uniformly, standing for 24 hours, filtering, recovering ethanol from the filtrate under reduced pressure, concentrating to prepare thick paste, and measuring the relative density at the temperature of 70 ℃ to be 1.3-1.4;
c. and c, crushing 1 part of Arabic gum and 8 parts of licorice extract into fine powder, adding the fine powder into the thick paste obtained in the step b, uniformly mixing, adding sucrose powder (80 meshes) and starch, uniformly mixing, granulating (14 meshes) by a conventional method, drying at the temperature of 60 ℃, cooling, dissolving the volatile oil obtained in the step a by using ethanol with the volume concentration of 95% to prepare an ethanol solution containing 70% of the volatile oil, spraying the ethanol solution into granules, and uniformly mixing to obtain the granular medicine for treating the cold of children and adults.
Example 4 (base of 20 g)
a. Putting 4 parts of hyssop into an extraction container, adding 6 times of water, extracting volatile oil for 4 hours, filtering distilled water solution for later use, collecting the volatile oil, including 5g of beta-cyclodextrin in each 1mL of the volatile oil, stirring for 1 hour at the temperature of 20 ℃, refrigerating overnight, performing suction filtration, drying for 4 hours at the temperature of 40 ℃, grinding, and sieving by a 100-mesh sieve to obtain a beta-cyclodextrin inclusion compound of the volatile oil for later use;
b. b, adding 10 times of water into the medicine residues, 8 parts of almond, 12 parts of hollyhock and 8 parts of water lily, decocting for 1 time for 2 hours, combining the decoction, filtering, combining the filtrate with the water solution obtained after distillation and filtration in the step a, concentrating until the relative density is 0.9-1.2, cooling to room temperature, adding 95% ethanol by volume to ensure that the alcohol content reaches 30% -75% by volume, stirring uniformly, standing for 24 hours, filtering, recovering ethanol from the filtrate under reduced pressure, concentrating to prepare thick paste, and measuring the relative density at 70 ℃ to be 1.3-1.4;
c. and c, crushing 2 parts of Arabic gum and 10 parts of licorice extract into fine powder, adding the fine powder into the thick paste obtained in the step b, uniformly mixing, adding sucrose powder (80 meshes), starch and the beta-cyclodextrin inclusion compound of the volatile oil obtained in the step a, uniformly mixing, granulating (14 meshes), drying at the temperature of 60 ℃, cooling, and preparing the granules for treating the cold of children and adults by a conventional pharmaceutical method.
Example 5 (base 20 g)
a. Placing 7 parts of hyssop into an extraction container, adding 7 times of water, extracting volatile oil for 6 hours, filtering the distilled water solution for later use, collecting the volatile oil, and dissolving the collected volatile oil with 95% ethanol by volume concentration to prepare 50% ethanol solution containing the volatile oil for later use;
b. b, adding 10 times of water into the medicine residues, 6 parts of almond, 9 parts of hollyhock and 7 parts of water lily, decocting for 3 times, each time lasting for 0.5 hour, filtering, combining the filtrate with the water solution obtained after distillation and filtration in the step a, concentrating to a solution with the relative density of 0.9-1.2 (measured at 50 ℃), cooling to room temperature, adding 95% ethanol by volume to ensure that the ethanol content reaches 30% -75% by volume, stirring uniformly, standing for 24 hours, filtering, recovering ethanol from the filtrate under reduced pressure, concentrating to prepare thick paste, and measuring the relative density at 70 ℃ to be 1.3-1.4;
c. and c, crushing 1.5 parts of Arabic gum and 7 parts of licorice extract into fine powder, adding the fine powder into the thick paste obtained in the step b, uniformly mixing, adding sucrose powder (80 meshes) and starch, uniformly mixing, granulating (14 meshes), drying at the temperature of 60 ℃, cooling, dissolving the volatile oil obtained in the step a by using ethanol with the volume concentration of 95% to prepare an ethanol solution containing 50% of the volatile oil, spraying the ethanol solution into the granules, and uniformly mixing to obtain the granular medicine for treating the cold of the children and adults.
Example 6 (base 20 g)
a. Putting 6 parts of hyssop officinalis in an extraction container, adding 10 times of water to extract volatile oil for 6 hours, filtering distilled water solution for later use, collecting the volatile oil, including 7g of beta-cyclodextrin in each 1mL of volatile oil, stirring for 1.5 hours at 20 ℃, refrigerating overnight, performing suction filtration, drying for 4 hours at 40 ℃, grinding, and sieving by a 100-mesh sieve to obtain a beta-cyclodextrin inclusion compound of the volatile oil for later use;
b. b, adding 8 times of water into the medicine residues, 6 parts of almond, 10 parts of hollyhock and 6 parts of water lily, decocting for 2 times, wherein each time is 1 hour, combining the decoction, filtering, combining the filtrate with the water solution obtained after distillation and filtration in the step a, concentrating until the relative density is 0.9-1.2, cooling to room temperature, adding 95% ethanol by volume to ensure that the ethanol content reaches 30% -75% by volume, stirring uniformly, standing for 24 hours, filtering, recovering ethanol from the filtrate under reduced pressure, concentrating to prepare thick paste, and measuring the relative density at 70 ℃ to be 1.3-1.4;
c. and c, crushing 1 part of Arabic gum and 8 parts of licorice extract into fine powder, adding the fine powder into the thick paste obtained in the step b, uniformly mixing, adding sucrose powder (80 meshes), starch and the beta-cyclodextrin inclusion compound of the volatile oil obtained in the step a, uniformly mixing, granulating (14 meshes), drying at the temperature of 60 ℃, cooling, and preparing the granules for treating the cold of children and adults by a conventional pharmaceutical method.
Example 7
The biological activity test of the medicine for treating cold of children and adults comprises the following steps:
effect of drug on number of cough in mice induced by ammonia:
materials:
experimental animals: KM mice, 18-22g weight, half male and half female, provided by Xinjiang laboratory animal research center. Producing a license number SCKX (New) 2011-0001, and using a license number SYXK (New) 2014-0002;
reagent: cough-relieving syrup (Guizhou Bailing, batch number: 20150600-1);
the method and the result are as follows:
taking 50 mice, wherein the mice are used for both male and female, the weight is 20.1 +/-1.1 g, the mice are randomly divided into a normal saline group, a cough-relieving syrup group and three drug groups with different dosages, ig administration is carried out once a day for three consecutive days, the mice are placed in a glass cover after the last administration for 1h, strong ammonia water is sprayed into the glass cover under the pressure of 140mmHg by a constant-pressure spraying device for 12 seconds, the cough frequency of the mice within 2min is recorded, and the data are shown in a table 1;
TABLE 1 Effect of drugs on the number of ammonia-induced cough in mice
* P <0.01, P <0.05 were all compared to NS group
Through statistical treatment, the positive drug cough-relieving syrup group and the three drug groups with different doses have significant differences from the normal saline group, which shows that the drug can obviously reduce the cough frequency of mice caused by ammonia water, and the reduction effect is enhanced along with the increase of the dose;
(II) influence of the medicine on the fever of the rat caused by the yeast:
materials:
experimental animals: SD rats with the body weight of 150-220g and half of male and female, provided by Xinjiang laboratory animal research center. Producing a license number SCKX (New) 2011-0001, and using a license number SYXK (New) 2014-0002;
reagent: ibuprofen sustained-release capsules (zhhai run du pharmaceutical products ltd., lot No. 3091509015), dry yeast (Angel yeast ltd., lot No. 20160412);
the method and the result are as follows:
taking 50 rats with the weight of 151.7 +/-5.6 g for both male and female, randomly dividing the rats into a normal saline group, an ibuprofen capsule group and three drug groups with different doses according to the weight and the sex, measuring the body temperature of each rat three times before the experiment, and taking the mean value of the body temperature as the basal body temperature. ig was dosed once daily for three consecutive days, with 3.0ml of 10% yeast suspension subcutaneously injected on the back per kg of body weight immediately after the last dose, body temperature was measured every other hour starting from the third hour from needle insertion, five times in a series, body temperature was recorded and calculated as the difference from basal body temperature, data are shown in table 2:
TABLE 2 Effect of drugs on Yeast-induced fever in rats
* P <0.01, P <0.05 all compared to NS group
Through statistical treatment, the ibuprofen positive drug group and the three drug groups with different doses have significant difference from the normal saline group, which indicates that the preparation can reduce the body temperature of the pyrogenic rat.
Claims (4)
1. The medicine for treating cold of children and adults is characterized by being prepared from 4-8 parts of almond, 4-8 parts of hyssop, 8-12 parts of hollyhock, 0.5-2 parts of arabic gum, 4-8 parts of nymphaea tetragona and 6-10 parts of liquorice extract by taking 20g as a base number.
2. The medicament of claim 1, wherein the cold is selected from the group consisting of the common cold and influenza.
3. The medicament as claimed in claim 2, wherein the causative agent of influenza is selected from influenza viruses.
4. The preparation method of the medicine for treating the cold of children and adults is characterized by comprising the following steps of taking 20g as a base number:
a. placing 4-8 parts of hyssop into an extraction container, adding 6-12 times of water, extracting volatile oil for 4-8 hours, filtering distilled water solution for later use, collecting the volatile oil, dissolving the collected volatile oil into ethanol solution containing 30-70% of the volatile oil by using 95% ethanol in volume concentration, or clathrating the collected volatile oil by using 3-7g of beta-cyclodextrin according to a conventional pharmaceutical method for later use;
b. decocting the residue, 4-8 parts of almond, 8-12 parts of hollyhock and 4-8 parts of water lily with 6-12 times of water for 1-3 times, each time for 0.5-2 hours, mixing the decoction, filtering, mixing the filtrate with the water solution obtained after distillation and filtration in the step a, concentrating until the relative density is 0.9-1.2, cooling to room temperature, adding 95% ethanol to ensure that the ethanol content reaches 30-75% of the volume ratio, stirring uniformly, standing for 24 hours, filtering, recovering ethanol from the filtrate under reduced pressure, and concentrating to obtain thick paste;
c. pulverizing 0.5-2 parts of Arabic gum and 6-10 parts of licorice extract into fine powder, adding into the thick paste obtained in step b, mixing the volatile oil beta-cyclodextrin inclusion compound prepared in step a with pharmaceutically acceptable auxiliary materials of sucrose powder and starch, adding into the thick paste, drying at 60 ℃, cooling, and preparing into granule medicine for treating common cold of children and adults by a conventional pharmaceutical method;
or pulverizing 1.5 parts of Arabic gum and 7 parts of licorice extract into fine powder, adding into the thick paste obtained in step b, mixing, adding sucrose powder and starch, mixing, granulating by a conventional pharmaceutical method, drying at 60 ℃, cooling, spraying the ethanol solution containing 30-70% of volatile oil prepared in step a into the granules, and mixing uniformly to obtain the granule medicine for treating children and adult cold.
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