CN101040950A - Method of preparing Ynxingchao dropping pills compound - Google Patents
Method of preparing Ynxingchao dropping pills compound Download PDFInfo
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- CN101040950A CN101040950A CNA2007100521140A CN200710052114A CN101040950A CN 101040950 A CN101040950 A CN 101040950A CN A2007100521140 A CNA2007100521140 A CN A2007100521140A CN 200710052114 A CN200710052114 A CN 200710052114A CN 101040950 A CN101040950 A CN 101040950A
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Abstract
The invention discloses a process for preparing compound houttuynia cordata dripping pill, wherein the raw materials include cordate houttuynia, baikal skullcap root, isatic root, capsule of weeping forsythia and honeysuckle flower. The preparing process comprises steps of extracting volatile oil, extracting the medicinal slag with water, filtering the extract, concentrating, alcohol depositing, concentrating the supernatant fluid into fluid extract, charging volatile oil, mixing homogenously, and charging into auxiliary matrix.
Description
Technical field
The invention belongs to field of Chinese herbal, refer more particularly to a kind of treat affection due to external wind and heat cause have sore throat, the preparation method of acute pharyngitis, tonsillitic FUFANG YUXINGCAO DIWAN.
Background technology
Pharyngitis, tonsillitis are the common symptoms of upper respiratory tract infection, and the traditional Chinese medical science belongs to throat moth, the sore throat category of larynx section, is that affection due to external wind and heat causes.Doctor trained in Western medicine is then thought, pharyngitis, tonsillitis are pharyngolaryngeal mucosa and adenoid inflammation thereof, the cause of disease mainly is stimulations such as antibacterial, viral infection, chemical factors dust, tobacco and wine, also can be secondary to the symptom in early stage of systemic disease or other diseases, treatment adopts antibiotics to be aided with methods such as buccal tablets agent mostly, but curative effect is often undesirable, though having, symptom alleviates, but the swelling and ache of throat, dried disease such as itch often delay difficult more, be difficult for eradicating, the several months that has does not heal, thereby has caused the antibiotic abuse.
The way that traditional Chinese medical science utilization organic conception and dialectical opinion control that external wind heat causes has sore throat, acute pharyngitis, tonsillitis often adopt heat-clearing and toxic substances removing.FUFANG YUXINGCAO DIWAN of the present invention has adopted Herba Houttuyniae, Radix Scutellariae, Radix Isatidis, Fructus Forsythiae, Flos Lonicerae five kinds of Chinese medicine, reaches pharynx-clearing throat-benefiting, toxic and side effects effect little, that do not show effect repeatedly by synergism.
The Herba Houttuyniae suffering is slightly cold, and returns lung meridian, has heat-clearing and toxic substances removing, an effect of pain evacuation of pus, the inducing diuresis for treating stranguria syndrome that disappear, and is monarch drug.Modern pharmacological research shows, that Herba Houttuyniae has is antibiotic, antiviral, immunomodulating, diuresis.Clinical have a report that it is treated 24 kinds of active chronic inflammations of 109 examples, proves that it has definite curative effect.
The Radix Scutellariae hardship, cold, return lung, gallbladder, spleen, large intestine, small intestine meridian, have heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive effect, be ministerial drug.The pharmacology report: it has antimicrobial effect, antiinflammatory and anti-allergy action.The low dosage baicalin can obviously promote the inductive mice spleen lymphocytes proliferation reaction of con A (ConA), high dose then significantly suppresses, and brings high blood pressure down and diuresis, effect for reducing blood fat, the gathering of anti-blood plate and anticoagulation, antioxidation, the central nervous system is had remarkable sedation.Clinical report treatment children's acute respiratory tract infection 51 examples, anxious chronic bronchitis tracheitis 11 examples, acute tonsillitis 1 example are controlled back body temperature and are reduced to normally transference cure person 51 examples, invalid 12 examples.
Radix Isatidis hardship, cold, GUIXIN, stomach warp have the effect of heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving.The pharmacology report, Radix Isatidis has antibacterium, antiviral effect, and anti-endotoxin effect, antitumaous effect have regulating action to immunity, the clinical child virus upper respiratory tract infection that is used for the treatment of, injection 182 examples, produce effects 60 examples, effective 12 examples, granule 50 examples, produce effects 20 examples, effective 16 examples.
The Fructus Forsythiae hardship is slightly cold, and returns lung, the heart, small intestine meridian.Effect with heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Pharmacological research shows that Fructus Forsythiae is the effective antimicrobial medicine of a kind of wide spectrum, and in vitro tests has inhibitory action to many kinds of antibacterials.The Chinese medicine of the clinical acute tonsillitis that is used for heat-clearing and toxic substances removing, pharyngitis, chronic bronchitis is more, is many with the Chinese medicine agent.At present, similar FUFANG YUXINGCAO PIAN, capsule are arranged on the market, not only production technology falls behind, and active constituent content is low, the quality standard imperfection, and also disintegrate is slow, and release is slow, and bioavailability is low, and curative effect has much room for improvement.
Summary of the invention
The preparation method that the purpose of this invention is to provide a kind of FUFANG YUXINGCAO DIWAN, the FUFANG YUXINGCAO DIWAN of this method preparation is a quick-effective preparation, its substrate can not only medicine carrying and is given the drop pill shape, and can utilize solid dispersion technology and its macromolecular material self-characteristic to increase the solvency and the dissolution of medicine, the performance drug effect is rapid, the bioavailability height is a welcome dosage form on the market.The inventor is improving technology, is analyzing dissolution, the standard that improves the quality, finishing on the basis of pharmacology pharmacodynamic comparison and finished the present invention.
The present invention is achieved like this, and is crude drug with Herba Houttuyniae, Radix Scutellariae, Radix Isatidis, Fructus Forsythiae, Flos Lonicerae, is prepared according to following steps.
1, Herba Houttuyniae, Radix Isatidis, Fructus Forsythiae, Flos Lonicerae are mixed or extract volatile oil separately;
2, above-mentioned four Chinese medicine pulp water is carried 2-3 time, and each 0.5-2 hour, predefecation was handled, and is concentrated into that to survey relative density in the time of 60 ℃ about 1.05～1.30, adds ethanol and makes and contain the alcohol amount and reach 55%-85%, filters, and reclaims ethanol and also is condensed into fluid extract;
3, Radix Scutellariae water is carried secondary, adds the water that 10-12 doubly measures at every turn, each 0.5-3 hour, the water extract suitably concentrates, transfer pH value to 1.0-3.0,60 ℃-95 ℃ are incubated 0.5-2.5 hour, left standstill 12-48 hour, filter, precipitate is washed with the ethanol of 30%-99%, and reuse is washed to PH4～7, cold drying, pulverize, get the Radix Scutellariae extract powder;
4, the Radix Scutellariae extract powder is joined in the above-mentioned fluid extract, add volatile oil, mixing joins in the adjuvant, and mixing drips and makes ball.
The percentage by weight of above crude drug is:
Herba Houttuyniae 20%-78% Radix Scutellariae 8%-25% Radix Isatidis 8%-25%
Fructus Forsythiae 1%-10% Flos Lonicerae 1%-10%
Above crude drug percentage by weight is preferred:
Herba Houttuyniae 40%-70% Radix Scutellariae 10%-20% Radix Isatidis 10%-20%
Fructus Forsythiae 3%-10% Flos Lonicerae 3%-10%
Preferred version is a Herba Houttuyniae 58.4%, Radix Scutellariae 15%, Radix Isatidis 15%, Fructus Forsythiae 5.8%, Flos Lonicerae 5.8%.
Get Herba Houttuyniae, Radix Isatidis, Fructus Forsythiae, Flos Lonicerae, the water logging that adds 12 times of amounts was steeped 2-5 hour, distillation, and volatile oil device is in addition preserved, and is standby; Medicinal residues filter, and filtrate [I] is deposited in addition; Medicinal residues add the water that 10-12 doubly measures to be continued to decoct 2-3 time, each 1-2 hour, collecting decoction filtered, merge with filtrate [I], be concentrated in the time of 60 ℃ and survey relative density about 1.15, put coldly, add ethanol and make and contain the alcohol amount and reach 70%, placed 24 hours, filter, filtrate recycling ethanol also continues to be condensed into fluid extract, and is standby; Get Radix Scutellariae, add the decocting that 10-12 doubly measures and boil secondary, each 0.5-3 hour, filter, merging filtrate is regulated pH value 1-3 with hydrochloric acid, and 60 ℃-95 ℃ are incubated 1 hour, left standstill 24 hours, filter, precipitation is washed with ethanol, and reuse is washed to PH4-7, the decompression cold drying, pulverize, get the Radix Scutellariae extract powder, join in the above-mentioned fluid extract, add volatile oil, mixing is got the PEG-6000 fusion, medicine is joined in the fused solution substrate, and medicine and substrate composition 1: 2-5 is advisable, preferred 1: 3.In following system of 65 ℃ of-90 ℃ of keeping warm modes, be condensing agent with liquid Paraffin or dimethicone, chilling temperature-5 ℃-0 ℃ is collected drop pill, wiping, promptly.
Can use supercritical extraction, water vapour distillation at the volatile oil of extraction described in the step.
Supernatant behind described water extract filtration and the precipitate with ethanol filters the available membrane separation technique of filter, common plate-and-frame filtration device carries out.
Described Radix Scutellariae water extract is regulated PH to 1.0-3.0 with acid, can be mineral acids such as hydrochloric acid, nitric acid, sulphuric acid, phosphoric acid, and alcohol is washed the ethanol that precipitate can be used 30%-99%.
The used adjuvant of described drop pill is that poly-ethanol class, sodium stearate, poloxamer are used alone or as a mixture.
Advantage of the present invention is: have the effect of heat-clearing and toxic substances removing, be used for that affection due to external wind and heat causes have sore throat, acute pharyngitis, tonsillitis.Clinically to upper respiratory tract infection, acute tonsillitis, pharyngitis, periodontitis, chronic bronchitis, lung abscess, inguinal bubo etc.
The specific embodiment
Embodiment 1
Herba Houttuyniae 1100g Radix Scutellariae 333g Radix Isatidis 333g
Fructus Forsythiae 116g Flos Lonicerae 116g
Get water logging bubble 2-5 hour that Herba Houttuyniae, Radix Isatidis, Fructus Forsythiae, Flos Lonicerae add 12 times of amounts, use water vapour distillation, volatile oil device preservation in addition, standby; Medicinal residues filter, and filtrate [I] is deposited in addition; Medicinal residues add the water that 10-12 doubly measures to be continued to decoct 2 times, each 1 hour, collecting decoction filtered, merge with filtrate [I], be concentrated in the time of 60 ℃ and survey relative density about 1.15, put coldly, add ethanol and make and contain the alcohol amount and reach 70%, placed 24 hours, filter, filtrate recycling ethanol also continues to be condensed into fluid extract, and is standby; Get Radix Scutellariae, add the decocting that 10-12 doubly measures and boil secondary, each 2 hours, filter, merging filtrate suitably concentrates, regulate pH value 1-2 with hydrochloric acid, 80 ℃ are incubated 1 hour, left standstill 24 hours, filter, precipitation is washed with 90% ethanol, and reuse is washed to PH5-6, the decompression cold drying is pulverized, and gets the Radix Scutellariae extract powder, join in the above-mentioned fluid extract, add volatile oil, mixing; Get the PEG-6000 fusion, medicine is joined in the fused solution substrate, medicine and substrate composition 1: 2-4 is advisable, preferred 1: 3.In following system of 65 ℃ of-90 ℃ of keeping warm modes, be condensing agent with the dimethicone, chilling temperature-4 ℃ is collected drop pill, wiping, promptly.
Embodiment 2
Herba Houttuyniae 1166g Radix Scutellariae 290g Radix Isatidis 290g
Fructus Forsythiae 126g Flos Lonicerae 126g
Get the water logging bubble 4 hours that Herba Houttuyniae, Radix Isatidis, Fructus Forsythiae, Flos Lonicerae add 12 times of amounts, use water vapour distillation, volatile oil device preservation in addition, standby; Medicinal residues filter, and filtrate [I] is deposited in addition; Medicinal residues add the water that 10-12 doubly measures to be continued to decoct 2 times, each 1.5 hours, collecting decoction filtered, merge with filtrate [I], be concentrated in the time of 60 ℃ and survey relative density about 1.15, put coldly, add ethanol and make and contain the alcohol amount and reach 70%, placed 24 hours, filter, filtrate recycling ethanol also continues to be condensed into fluid extract, and is standby; Get Radix Scutellariae, add the decocting that 10-12 doubly measures and boil secondary, each 0.5-3 hour, filter, merging filtrate is concentrated into medical material 15 amounts, regulate pH value about 2 with sulphuric acid, 90 ℃ are incubated 1 hour, left standstill 36 hours, filter, precipitation is washed with 70% ethanol, and reuse is washed to PH5-6, the decompression cold drying is pulverized, and gets the Radix Scutellariae extract powder, join in the above-mentioned fluid extract, add volatile oil, mixing, get the sodium stearate fusion, medicine is joined in the fused solution substrate, medicine and substrate composition are advisable at 1: 3, in following system of 75 ℃ of keeping warm modes, with the liquid Paraffin is condensing agent, and chilling temperature-5 ℃ is collected drop pill, wiping, promptly.
Claims (7)
1, a kind of preparation method of FUFANG YUXINGCAO DIWAN is that crude drug is made by Herba Houttuyniae, Radix Scutellariae, Radix Isatidis, Fructus Forsythiae, Flos Lonicerae, it is characterized in that its preparation method is:
(1) Herba Houttuyniae, Radix Isatidis, Fructus Forsythiae, Flos Lonicerae are mixed or extract volatile oil separately, collect volatile oil, standby;
(2) above-mentioned aftertaste medicinal residues water is carried, and filters, and filtrate is concentrated into and surveys relative density in the time of 60 ℃ is 1.05～1.30, adds ethanol, makes to contain the alcohol amount and reach 55%-85%, filters, and reclaims ethanol, makes fluid extract;
(3) Radix Scutellariae water is carried, and the water extract is transferred ℃ of-95 ℃ insulations in PH to 1.0～3.0,60 0.5-2.5 hour, leaves standstill 12-48 hour, filters, and PH4-7 is washed, is washed to precipitation with ethanol, and cold drying is pulverized, the Radix Scutellariae extract powder;
(4) the Radix Scutellariae extract powder is joined in the fluid extract, add volatile oil, mixing joins in the adjuvant, and mixing is made drop pill.
2, the preparation method of FUFANG YUXINGCAO DIWAN according to claim 1 is characterized in that the percentage by weight of described crude drug is:
Herba Houttuyniae 20%-78% Radix Scutellariae 8%-25% Radix Isatidis 8%-25%
Fructus Forsythiae 1%-10% Flos Lonicerae 1%-10%
3, the preparation method of FUFANG YUXINGCAO DIWAN according to claim 1 is characterized in that described crude drug percentage by weight is:
Herba Houttuyniae 40%-70% Radix Scutellariae 10%-20% Radix Isatidis 10%-20%
Fructus Forsythiae 3%-8% Flos Lonicerae 3%-8%
4,, it is characterized in that described extraction volatile oil can use supercritical extraction, water vapour distillation according to the described preparation method of claim 1-3.
5,, it is characterized in that the supernatant behind described water extract filtration and the precipitate with ethanol filters the available membrane separation technique of filter, common plate-and-frame filtration device carries out according to the described preparation method of claim 1-3.
6, according to the desirable described preparation method of 1-3 that requires, it is characterized in that described Radix Scutellariae water extract with acid adjusting PH to 1.0-3.0, can be mineral acids such as hydrochloric acid, nitric acid, sulphuric acid, phosphoric acid, alcohol is washed the ethanol that precipitate can be used 30%-99%.
7,, it is characterized in that the used adjuvant of described drop pill is that polyethylene glycols, sodium stearate, poloxamer are used alone or as a mixture according to the described preparation method of claim 1-3.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2007100521140A CN101040950B (en) | 2007-04-29 | 2007-04-29 | Method of preparing compound Houttuynia cordata dropping pills |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2007100521140A CN101040950B (en) | 2007-04-29 | 2007-04-29 | Method of preparing compound Houttuynia cordata dropping pills |
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| CN101040950A true CN101040950A (en) | 2007-09-26 |
| CN101040950B CN101040950B (en) | 2012-02-22 |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102018810A (en) * | 2010-12-09 | 2011-04-20 | 浙江惠松制药有限公司 | Preparation method of compound Houttuynia cordata mixture |
| CN101683182B (en) * | 2008-09-27 | 2012-07-04 | 湖北中烟工业有限责任公司 | Heartleaf houttuynia herb and radix isatidis compound extract and application thereof as additive of tobacco product |
| CN103494928A (en) * | 2013-09-29 | 2014-01-08 | 江西天施康中药股份有限公司 | Preparation method for compound houttuynia cordata preparation |
| CN103520227A (en) * | 2013-10-09 | 2014-01-22 | 南京农业大学 | Injectable Isatis Root in-situ gel, and preparation method thereof |
| CN104435113A (en) * | 2014-12-16 | 2015-03-25 | 江西天施康中药股份有限公司 | Preparation method of scutellaria baicalensis extract for preparing compound houttuynia cordata dropping pills |
| CN107474963A (en) * | 2017-09-01 | 2017-12-15 | 云南巴菰生物科技有限公司 | A kind of cordate houttuynia essential oil cigarette is with quick-fried pearl and preparation method thereof |
| CN109012185A (en) * | 2018-08-23 | 2018-12-18 | 河北维尔利动物药业集团有限公司 | Membrane separation technique takes orally the application in liquid preparing process in cordate houttuynia a kind of reed mentioned in ancient books indigo plant |
| CN109481527A (en) * | 2017-09-11 | 2019-03-19 | 石家庄以岭药业股份有限公司 | It is a kind of prepare prevention or treat mouth disease Chinese medicine composition and its application |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1548104A (en) * | 2003-05-24 | 2004-11-24 | 毛友昌 | Compound cordate bouttuynia bolus and its prepn |
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2007
- 2007-04-29 CN CN2007100521140A patent/CN101040950B/en active Active
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101683182B (en) * | 2008-09-27 | 2012-07-04 | 湖北中烟工业有限责任公司 | Heartleaf houttuynia herb and radix isatidis compound extract and application thereof as additive of tobacco product |
| CN102018810A (en) * | 2010-12-09 | 2011-04-20 | 浙江惠松制药有限公司 | Preparation method of compound Houttuynia cordata mixture |
| CN102018810B (en) * | 2010-12-09 | 2012-01-11 | 浙江惠松制药有限公司 | Preparation method of compound Houttuynia cordata mixture |
| CN103494928A (en) * | 2013-09-29 | 2014-01-08 | 江西天施康中药股份有限公司 | Preparation method for compound houttuynia cordata preparation |
| CN103520227A (en) * | 2013-10-09 | 2014-01-22 | 南京农业大学 | Injectable Isatis Root in-situ gel, and preparation method thereof |
| CN104435113A (en) * | 2014-12-16 | 2015-03-25 | 江西天施康中药股份有限公司 | Preparation method of scutellaria baicalensis extract for preparing compound houttuynia cordata dropping pills |
| CN104435113B (en) * | 2014-12-16 | 2018-06-19 | 江西天施康中药股份有限公司 | It is used to prepare the preparation method of the Baical Skullcap root P.E of Ynxingchao dropping pills compound |
| CN107474963A (en) * | 2017-09-01 | 2017-12-15 | 云南巴菰生物科技有限公司 | A kind of cordate houttuynia essential oil cigarette is with quick-fried pearl and preparation method thereof |
| CN109481527A (en) * | 2017-09-11 | 2019-03-19 | 石家庄以岭药业股份有限公司 | It is a kind of prepare prevention or treat mouth disease Chinese medicine composition and its application |
| CN109012185A (en) * | 2018-08-23 | 2018-12-18 | 河北维尔利动物药业集团有限公司 | Membrane separation technique takes orally the application in liquid preparing process in cordate houttuynia a kind of reed mentioned in ancient books indigo plant |
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| CN101040950B (en) | 2012-02-22 |
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Address after: 335200 north of national highway 320, Jiaotong North Road, Yujiang District, Yingtan City, Jiangxi Province Patentee after: Jiangxi Kangenbei tianshikang Pharmaceutical Co.,Ltd. Address before: 21 Jianshe Road, Yingtan City, Jiangxi Province Patentee before: Jiangxi Herbi-Sky Co.,Ltd. |
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