CN1386542A - Chinese-medicinal oral liquid for treating rhinitis and nasosinusitis and its preparing process - Google Patents
Chinese-medicinal oral liquid for treating rhinitis and nasosinusitis and its preparing process Download PDFInfo
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- CN1386542A CN1386542A CN 02122901 CN02122901A CN1386542A CN 1386542 A CN1386542 A CN 1386542A CN 02122901 CN02122901 CN 02122901 CN 02122901 A CN02122901 A CN 02122901A CN 1386542 A CN1386542 A CN 1386542A
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Abstract
A Chinese medicine in the form of oral liquid for treating rhinitis and nasosinusitis is prepared from 15 Chinese-medicinal materials including ledebouriella root, magnolia flower, asarum herb, houttuynia, etc through extracting, mixing and regulating concentration. Its advantages are high curative effect (98.9% for total effective rate) and quickly taking its effect.
Description
Technical field
The present invention relates to Chinese medicine oral liquid for the treatment of rhinitis, sinusitis and preparation method thereof, belong to Chinese medicine preparation and preparation method thereof technical field.
Background technology
Rhinitis, sinusitis are commonly encountered diseases and frequently-occurring diseases clinically, and the teenager morbidity of growth and development stage is more.Chronic rhinitis, sinusitis patient have a strong impact on people's life and health often with distraction, loss of appetite even dysplasia etc.The Chinese medicine preparation of existing treatment rhinitis, sinusitis exists take effect slow, relatively poor, the side effect significant disadvantages of curative effect more, can not be accepted by extensive patients.In view of this, should develop new treatment rhinitis, the Chinese medicine preparation of sinusitis.
Summary of the invention
Technical problem to be solved by this invention provide and can remove rapidly, alleviate nasal obstruction and thus due to symptoms such as headache, feeling of fullness in the head, reduce the treatment acute or chronic rhinitis of pus tears, Chinese medicine oral liquid of sinusitis and preparation method thereof, take effect slowly to overcome existing treatment rhinitis, sinusitis Chinese medicine preparation, the relatively poor shortcoming of curative effect.
Technical problem to be solved by this invention is achieved by the following scheme:
A kind of Chinese medicine oral liquid for the treatment of rhinitis, sinusitis comprises following raw material medicaments and extracts of bulk drugs (weight portion, down together) during it is formed:
Radix Saposhnikoviae, Flos Magnoliae, Herba Asari, Herba Houttuyniae, Rhizoma Ligustici, Herba Menthae, Fructus Xanthii, Rhizoma Acori Graminei, Rhizoma Et Radix Notopterygii distillating extracting liquid 10-500, the Radix Angelicae Dahuricae, Herba Taraxaci, Herba Patriniae, Poria, Fructus Liquidambaris, Radix Platycodonis boil and carry, precipitate with ethanol extracting solution 12-660; The crude drug proportioning of described distillation extract is: Radix Saposhnikoviae 2.5-23, Flos Magnoliae 1.5-21, Herba Asari 0.5-6, Herba Houttuyniae 1.2-30, Rhizoma Ligustici 2-26, Herba Menthae 0.8-12, Fructus Xanthii 1-22, stone Rhizoma Acori Graminei 3-24, Rhizoma Et Radix Notopterygii 1.5-20; Described boil carry, the crude drug proportioning of precipitate with ethanol extracting solution is Radix Angelicae Dahuricae 1.2-20, Herba Taraxaci 5-38, Herba Patriniae 6-36, Poria 2-27, Fructus Liquidambaris 2-21, Radix Platycodonis 1.6-22.
The Chinese medicine oral liquid of above-mentioned treatment rhinitis, sinusitis, described boiling carried, also comprised above-mentioned Radix Saposhnikoviae, Flos Magnoliae, Herba Asari, Herba Houttuyniae, Rhizoma Ligustici, Herba Menthae, Fructus Xanthii, Rhizoma Acori Graminei, the surplus medicinal residues of Rhizoma Et Radix Notopterygii distillation extraction in the crude drug of precipitate with ethanol extracting solution.
A kind of manufacture method for the treatment of rhinitis, sinusitis Chinese medicine oral liquid, it comprises following operation:
(1). the preparation distillating extracting liquid:
Take by weighing Radix Saposhnikoviae (weight portion, 2.5-23, Flos Magnoliae 1.5-21, Herba Asari 0.5-6, Herba Houttuyniae 1.2-30, Rhizoma Ligustici 2-26, Herba Menthae 0.8-12, Fructus Xanthii 1-22, Rhizoma Acori Graminei 3-24, Rhizoma Et Radix Notopterygii 1.5-20 down together), add dose 3-10 water doubly, soaked 10-50 minute, distillate 15-700 is collected in 45 ℃ of-85 ℃ of distillations;
(2). preparation is boiled and is carried, the precipitate with ethanol extracting solution
Take by weighing the Radix Angelicae Dahuricae (weight portion, down together) 1.2-20, Herba Taraxaci 5-38, Herba Patriniae 6-36, Poria 2-27, Fructus Liquidambaris 2-21, Radix Platycodonis 1.6-22 add in the extractor, add water 180-10000,30 ℃-65 ℃ were soaked 20-90 minute, heating is boiled and is carried 30-120 minute, filter, be concentrated into 15-750, separate, get supernatant 12-660, add 95% ethanol and be 30%-80%, leave standstill, cold preservation 12-60 hour, supernatant liquid filtering to containing alcohol amount, decompression recycling ethanol, left standstill cold preservation 12-60 hour, the elimination precipitation, the dosing water transfers to 12-660.
(3). merge, adjust concentration
With distillate 15-700 with boil carry, precipitate with ethanol extracting solution 12-660 merging, mixing, the packing of adjustment concentration, sterilization.
The manufacture method of above-mentioned treatment rhinitis, sinusitis Chinese medicine oral liquid, in the described preparation distillating extracting liquid operation, can be with distillate rectification once more, the final rectification liquid 10-500 that gets returns smart rectificated remaining liquid in the extractor again;
The manufacture method of above-mentioned treatment rhinitis, sinusitis Chinese medicine oral liquid, described preparation is boiled and is carried, in the precipitate with ethanol extracting solution operation, also can in extractor, add distillation surplus medicinal residues of institute and still residue, heat to boil with the said medicine that is taken by weighing and carry 30-120 minute, after the filtration, also medicinal residues can be added water 200-11000 again, boil and carry 30-120 minute, merge leach cooking liquid twice, be evaporated to 15-750;
The manufacture method of above-mentioned treatment rhinitis, sinusitis Chinese medicine oral liquid, described preparation boil the separation mentioned in the alcohol extract operation can for: airtight cold preservation 12-48 hour, get supernatant.
In the selected raw material of Chinese medicine of the present invention, the Radix Angelicae Dahuricae, Fructus Xanthii, Flos Magnoliae, have that diffusing wind-dryness is wet, dispelling wind to relieve the exterior syndrome, lung qi dispersing are sensible, dispel the wind, end forehead pain and shrink nasal mucosa vessels, convergence ends the antianaphylactic effect of tears, Rhizoma Ligustici is ended top of the head pain, it is up that Herba Asari draws all medicines, the sensible therapeutic method to keep the adverse QI flowing downwards, Herba Taraxaci, Herba Patriniae, Herba Houttuyniae heat-clearing and toxic substances removing, removing heat from blood, inducing diuresis to remove edema.Each performs its own functions for all medicines, complements each other reasonable recipe.Can extract the contained volatile effective component of crude drug to large extent with manufacture method of the present invention and strengthen curative effect, overcome the deficiencies in the prior art.Clinical observation shows, can remove rapidly, alleviate behind the oral liquid of the present invention clothes nasal obstruction and thus due to symptoms such as headache, feeling of fullness in the head, reduce the pus tears, improve and the recovery olfactory function, evident in efficacy, total effective rate reaches 98.9%, is comparatively ideal at present acute or chronic rhinitis, sinusitis medicine.
The specific embodiment
Embodiment 1
Comprise following raw material medicaments and extracts of bulk drugs (weight portion, down together) in its composition of present embodiment Chinese medicine preparation respectively:
The distillating extracting liquid 120 of Radix Saposhnikoviae, Flos Magnoliae, Herba Asari, Herba Houttuyniae, Rhizoma Ligustici, Herba Menthae, Fructus Xanthii, Rhizoma Acori Graminei, Rhizoma Et Radix Notopterygii, the above-mentioned distillation extraction medicinal residues and the Radix Angelicae Dahuricae, Herba Taraxaci, Herba Patriniae, Poria, Fructus Liquidambaris, Radix Platycodonis boil carries precipitate with ethanol extracting solution 500; The crude drug of described distillating extracting liquid is: Radix Saposhnikoviae 8, Flos Magnoliae 1.5, Herba Asari 6, Herba Houttuyniae 20, Rhizoma Ligustici 10, Herba Menthae 0.8, Fructus Xanthii 12, Rhizoma Acori Graminei 22, Rhizoma Et Radix Notopterygii 9; The described crude drug of carrying the precipitate with ethanol extracting solution that boils is the Radix Angelicae Dahuricae 12, Herba Taraxaci 38, Herba Patriniae 16, Poria 3, Fructus Liquidambaris 21, Radix Platycodonis 2.
The manufacture method that the present invention treats rhinitis, sinusitis Chinese medicine oral liquid comprises following operation:
(1). the preparation distillating extracting liquid:
Take by weighing Radix Saposhnikoviae (weight portion, down together) 8, Flos Magnoliae 1.5, Herba Asari 6, Herba Houttuyniae 20, Rhizoma Ligustici 10, Herba Menthae 0.8, Fructus Xanthii 12, Rhizoma Acori Graminei 22, Rhizoma Et Radix Notopterygii 9, add the water of 7 times of doses, soaked 25 minutes, distillating extracting liquid 120 is collected in 75 ℃ of distillations;
(2). preparation is boiled and is carried, the precipitate with ethanol extracting solution
Take by weighing the Radix Angelicae Dahuricae (weight portion, down together) 2, Herba Taraxaci 16, Herba Patriniae 15, Poria 17, Fructus Liquidambaris 5, Radix Platycodonis 22, add distillation surplus medicinal residues of institute and still residue and go in the extractor, add 1500,55 ℃ in water and soaked 70 minutes, heating is boiled and is carried 100 minutes, filter, be concentrated into 640, airtight cold preservation 30 hours, get supernatant 500, adding 95% ethanol to the alcohol amount of containing is 55%, leaves standstill, cold preservation 50 hours, decompression recycling ethanol, left standstill cold preservation 50 hours, the elimination precipitation, the dosing water transfers to 500.
(3). merge, adjust concentration
With distillating extracting liquid 120 with boil carry, 500 merging of precipitate with ethanol extracting solution, mixing, the packing of adjustment concentration, sterilization.
Embodiment 2
The treatment rhinitis of present embodiment, the Chinese medicine oral liquid of sinusitis comprise following raw material medicaments and extracts of bulk drugs (weight portion, down together) during it is formed:
The distillating extracting liquid 490 of Radix Saposhnikoviae, Flos Magnoliae, Herba Asari, Herba Houttuyniae, Rhizoma Ligustici, Herba Menthae, Fructus Xanthii, Rhizoma Acori Graminei, Rhizoma Et Radix Notopterygii, the Radix Angelicae Dahuricae, Herba Taraxaci, Herba Patriniae, Poria, Fructus Liquidambaris, Radix Platycodonis boil carries precipitate with ethanol extracting solution 660; The crude drug proportioning of described distillating extracting liquid is: Radix Saposhnikoviae 23, Flos Magnoliae 10, Herba Asari 3, Herba Houttuyniae 1.2, Rhizoma Ligustici 3, Herba Menthae 11, Fructus Xanthii 2, Rhizoma Acori Graminei 3, Rhizoma Et Radix Notopterygii 12; The described crude drug proportioning of mentioning alcohol extract of boiling is the Radix Angelicae Dahuricae 19, Herba Taraxaci 15, Herba Patriniae 35, Poria 27, Fructus Liquidambaris 10, Radix Platycodonis 12.
The manufacture method of present embodiment Chinese medicine oral liquid comprises following operation:
(1). the preparation distillating extracting liquid:
Take by weighing Radix Saposhnikoviae (weight portion, down together) 23, Flos Magnoliae 10, Herba Asari 3, Herba Houttuyniae 1.2, Rhizoma Ligustici 3, Herba Menthae 11, Fructus Xanthii 2, Rhizoma Acori Graminei 3, Rhizoma Et Radix Notopterygii 12, add the water of 3 times of doses, soaked 10 minutes, distillate 100 is collected in 85 ℃ of distillations; With distillate rectification secondary once more, final rectification liquid 50 returns smart rectificated remaining liquid in the extractor again;
(2). preparation is boiled and is mentioned alcohol extract
Take by weighing the Radix Angelicae Dahuricae (weight portion, down with) 19, Herba Taraxaci 15, Herba Patriniae 35, Poria 27, Fructus Liquidambaris 10, Radix Platycodonis 12, add and be equipped with in the extractor of smart rectificated remaining liquid, add water 10000,65 ℃ were soaked 20 minutes, heating is boiled and is carried 120 minutes, filters, and medicinal residues add water 800 again, boil and carry 60 minutes, merge leach cooking liquid twice, be evaporated to 600, airtight cold preservation 12 hours, get supernatant 500, adding 95% ethanol to the alcohol amount of containing is 75%, leaves standstill, cold preservation 15 hours decompression recycling ethanol, arrange 25 with distilled water, left standstill cold preservation 60 hours, the elimination precipitation, the dosing water transfers to 450.
(3). merge, adjust concentration
Distillate 50 is proposed 450 merging of precipitate with ethanol extracting solution, mixing, the packing of adjustment concentration, sterilization with boiling.
Embodiment 3
Comprise following raw material medicaments and extracts of bulk drugs (weight portion, down together) in its composition of present embodiment Chinese medicine preparation respectively:
The distillating extracting liquid 160 of Radix Saposhnikoviae, Flos Magnoliae, Herba Asari, Herba Houttuyniae, Rhizoma Ligustici, Herba Menthae, Fructus Xanthii, Rhizoma Acori Graminei, Rhizoma Et Radix Notopterygii, the Radix Angelicae Dahuricae, Herba Taraxaci, Herba Patriniae, Poria, Fructus Liquidambaris, Radix Platycodonis boil carries precipitate with ethanol extracting solution 60; The crude drug proportioning of described distillating extracting liquid is: Radix Saposhnikoviae 2.5, Flos Magnoliae 20, Herba Asari 0.5, Herba Houttuyniae 30, Rhizoma Ligustici 26, Herba Menthae 3, Fructus Xanthii 20, Rhizoma Acori Graminei 10, Rhizoma Et Radix Notopterygii 20; The described crude drug proportioning of carrying the precipitate with ethanol extracting solution of boiling is the Radix Angelicae Dahuricae 1.2, Herba Taraxaci 5, Herba Patriniae 8, Poria 15, Fructus Liquidambaris 2, Radix Platycodonis 12.
The manufacture method of present embodiment Chinese medicine oral liquid comprises following operation:
(1). the preparation distillating extracting liquid:
Take by weighing Radix Saposhnikoviae (weight portion, down together) 2.5, Flos Magnoliae 20, Herba Asari 0.5, Herba Houttuyniae 30, Rhizoma Ligustici 26, Herba Menthae 3, Fructus Xanthii 20, Rhizoma Acori Graminei 10, Rhizoma Et Radix Notopterygii 20, add the water of 10 times of doses, soaked 20 minutes, distillate 280 is collected in 45 ℃ of distillations; With distillate rectification secondary once more, final rectification liquid 160 returns smart rectificated remaining liquid in the extractor again;
(2). preparation is boiled and is mentioned alcohol extract
Take by weighing the Radix Angelicae Dahuricae (weight portion, down with) 1.2, Herba Taraxaci 5, Herba Patriniae 8, Poria 15, Fructus Liquidambaris 2, Radix Platycodonis 12, and the residue adding is equipped with in the extractor of smart rectificated remaining liquid after the distillation, adds 700,32 ℃ in water and soaks 90 minutes, heating is boiled and is carried 35 minutes, filter, medicinal residues add water 800 again, boil and carry 60 minutes, merge leach cooking liquid twice, be evaporated to 260, supernatant is got in airtight cold preservation 48 hours, adding 95% ethanol is 35% to containing the alcohol amount, leave standstill, cold preservation 15 hours, decompression recycling ethanol left standstill cold preservation 48 hours, the elimination precipitation, the dosing water transfers to 60.
(3). merge, adjust concentration
Rectification liquid 160 is proposed 60 merging of precipitate with ethanol extracting solution, mixing, the packing of adjustment concentration, sterilization with boiling.
Claims (7)
1. a Chinese medicine oral liquid for the treatment of rhinitis, sinusitis is characterized in that, comprises following raw material medicaments and extracts of bulk drugs (weight portion, down together) in the composition:
Radix Saposhnikoviae, Flos Magnoliae, Herba Asari, Herba Houttuyniae, Rhizoma Ligustici, Herba Menthae, Fructus Xanthii, Rhizoma Acori Graminei, Rhizoma Et Radix Notopterygii distillating extracting liquid 10-500, the Radix Angelicae Dahuricae, Herba Taraxaci, Herba Patriniae, Poria, Fructus Liquidambaris, Radix Platycodonis boil and carry, precipitate with ethanol extracting solution 12-660; The crude drug proportioning of described distillation extract is: Radix Saposhnikoviae 2.5-23, Flos Magnoliae 1.5-21, Herba Asari 0.5-6, Herba Houttuyniae 1.2-30, Rhizoma Ligustici 2-26, Herba Menthae 0.8-12, Fructus Xanthii 1-22, stone Rhizoma Acori Graminei 3-24, Rhizoma Et Radix Notopterygii 1.5-20; Described boil carry, the crude drug proportioning of precipitate with ethanol extracting solution is Radix Angelicae Dahuricae 1.2-20, Herba Taraxaci 5-38, Herba Patriniae 6-36, Poria 2-27, Fructus Liquidambaris 2-21, Radix Platycodonis 1.6-22.
2. the Chinese medicine oral liquid of treatment rhinitis according to claim 1, sinusitis, it is characterized in that described boiling carried, also comprised above-mentioned Radix Saposhnikoviae, Flos Magnoliae, Herba Asari, Herba Houttuyniae, Rhizoma Ligustici, Herba Menthae, Fructus Xanthii, Rhizoma Acori Graminei, the surplus medicinal residues of Rhizoma Et Radix Notopterygii distillation extraction in the crude drug of precipitate with ethanol extracting solution.
3. manufacture method for the treatment of rhinitis, sinusitis Chinese medicine oral liquid is characterized in that it comprises following operation:
(1). the preparation distillating extracting liquid:
Take by weighing Radix Saposhnikoviae (weight portion, 2.5-23, Flos Magnoliae 1.5-21, Herba Asari 0.5-6, Herba Houttuyniae 1.2-30, Rhizoma Ligustici 2-26, Herba Menthae 0.8-12, Fructus Xanthii 1-22, Rhizoma Acori Graminei 3-24, Rhizoma Et Radix Notopterygii 1.5-20 down together), add dose 3-10 water doubly, soaked 10-50 minute, distillate 15-700 is collected in 45 ℃ of-85 ℃ of distillations;
(2). preparation is boiled and is carried, the precipitate with ethanol extracting solution
Take by weighing the Radix Angelicae Dahuricae (weight portion, down together) 1.2-20, Herba Taraxaci 5-38, Herba Patriniae 6-36, Poria 2-27, Fructus Liquidambaris 2-21, Radix Platycodonis 1.6-22 add in the extractor, add water 180-10000,30 ℃-65 ℃ were soaked 20-90 minute, heating is boiled and is carried 30-120 minute, filter, be concentrated into 15-750, separate, get supernatant 12-660, add 95% ethanol and be 30%-80%, leave standstill, cold preservation 12-60 hour, supernatant liquid filtering to containing alcohol amount, decompression recycling ethanol, left standstill cold preservation 12-60 hour, the elimination precipitation, the dosing water transfers to 12-660;
(3). merge, adjust concentration
With distillate 15-700 with boil carry, precipitate with ethanol extracting solution 12-660 merging, mixing, the packing of adjustment concentration, sterilization.
4. according to the manufacture method of the described treatment rhinitis of claim 3, sinusitis Chinese medicine oral liquid, it is characterized in that, in the described preparation distillating extracting liquid operation, can be with distillate rectification once more, the final rectification liquid 10-500 that gets returns smart rectificated remaining liquid in the extractor again.
5. according to claim 3 or 4 described treatment rhinitis, the manufacture method of sinusitis Chinese medicine oral liquid, it is characterized in that, described preparation is boiled and is carried, in the precipitate with ethanol extracting solution operation, also can in extractor, add distillation surplus medicinal residues of institute and still residue, heat to boil with the said medicine that is taken by weighing and carry 30-120 minute, filter, medicinal residues are added water 200-11000 again, boil and carry 30-120 minute, merge leach cooking liquid twice, be evaporated to 15-750.
6. according to claim 3 or 4 described treatment rhinitis, the manufacture method of sinusitis Chinese medicine oral liquid, it is characterized in that, described preparation boil the separation mentioned in the alcohol extract operation can for: airtight cold preservation 12-48 hour, get supernatant.
7. the manufacture method of treatment rhinitis according to claim 5, sinusitis Chinese medicine oral liquid is characterized in that, described preparation boil the separation mentioned in the alcohol extract operation can for: airtight cold preservation 12-48 hour, get supernatant.
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Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1943738B (en) * | 2006-10-23 | 2010-06-09 | 杨磊 | A medicine for treatment of chronic nasosinusitis |
CN101700329B (en) * | 2009-10-30 | 2011-06-15 | 蔡云娥 | Traditional Chinese medicine for treating wind-heat rhinitis |
CN102188683A (en) * | 2011-05-05 | 2011-09-21 | 苏士峥 | Preparation method of traditional Chinese medicine for treating otitis media with nasal swelling |
CN101204479B (en) * | 2007-12-13 | 2011-11-16 | 张益军 | Chinese traditional medicine preparation for acute sinusitis |
CN102641380A (en) * | 2012-03-29 | 2012-08-22 | 谈钰元 | Traditional Chinese medicine compound preparation for treating rhinitis and nasosinusitis and preparation process thereof |
CN103463213A (en) * | 2012-06-08 | 2013-12-25 | 南通亿仕得医疗器械有限公司 | Traditional Chinese medicine formula for treatment of rhinitis and manufacturing method thereof |
CN103584598A (en) * | 2013-11-15 | 2014-02-19 | 张虎 | Traditional Chinese medicine pillow for treating chronic rhinitis |
CN105748736A (en) * | 2016-05-12 | 2016-07-13 | 王维娜 | Traditional Chinese medicine composition for treating chronic nasosinusitis as well as preparation method and application of traditional Chinese medicine composition |
-
2002
- 2002-06-05 CN CN 02122901 patent/CN1205952C/en not_active Expired - Fee Related
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1943738B (en) * | 2006-10-23 | 2010-06-09 | 杨磊 | A medicine for treatment of chronic nasosinusitis |
CN101204479B (en) * | 2007-12-13 | 2011-11-16 | 张益军 | Chinese traditional medicine preparation for acute sinusitis |
CN101700329B (en) * | 2009-10-30 | 2011-06-15 | 蔡云娥 | Traditional Chinese medicine for treating wind-heat rhinitis |
CN102188683A (en) * | 2011-05-05 | 2011-09-21 | 苏士峥 | Preparation method of traditional Chinese medicine for treating otitis media with nasal swelling |
CN102641380A (en) * | 2012-03-29 | 2012-08-22 | 谈钰元 | Traditional Chinese medicine compound preparation for treating rhinitis and nasosinusitis and preparation process thereof |
CN102641380B (en) * | 2012-03-29 | 2013-12-18 | 谈钰元 | Traditional Chinese medicine compound preparation for treating rhinitis and nasosinusitis and preparation process thereof |
CN103463213A (en) * | 2012-06-08 | 2013-12-25 | 南通亿仕得医疗器械有限公司 | Traditional Chinese medicine formula for treatment of rhinitis and manufacturing method thereof |
CN103584598A (en) * | 2013-11-15 | 2014-02-19 | 张虎 | Traditional Chinese medicine pillow for treating chronic rhinitis |
CN105748736A (en) * | 2016-05-12 | 2016-07-13 | 王维娜 | Traditional Chinese medicine composition for treating chronic nasosinusitis as well as preparation method and application of traditional Chinese medicine composition |
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