CN101112403A - Production technology of Chinese traditional medicine plant pokeweed extract - Google Patents
Production technology of Chinese traditional medicine plant pokeweed extract Download PDFInfo
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- CN101112403A CN101112403A CNA2007100184715A CN200710018471A CN101112403A CN 101112403 A CN101112403 A CN 101112403A CN A2007100184715 A CNA2007100184715 A CN A2007100184715A CN 200710018471 A CN200710018471 A CN 200710018471A CN 101112403 A CN101112403 A CN 101112403A
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Abstract
The present invention relates to a manufacturing technique of a phytolacca acinosa roxb extract which is a traditional Chinese herb of pharmaceutical raw materials and is used for respiratory, the invention can be divided into ethanol extraction and purified water extraction. The phytolacca acinosa roxb extract produced by the process can act on the tracheal mucosa directly to promote the sputum dispelling, enhance movement of the cilia, reduce permeability of the capillary, mitigate the swelling of the tracheal mucosa and reduce the leakage, furthermore, the extract can excite pituitary---adrenal system by influencing the central nervous system (brainstem) so as to dispel the sputum and relieve the cough and treat the chronic bronchitis, particularly the chronic bronchitis of the old patients. The sputum dispelling tables which are produced by phytolacca acinosa roxb extract has the advantages of short treatment course, accurate efficacy, low price and easy administration.
Description
One, technical field
The present invention relates to a kind of production technology of respiratory drugs Chinese medicinal plant Radix phytolaccae extract, it is a kind of crude drug that is used for the treatment of chronic tracheitis, particularly treats the medicine of chronic senile tracheitis.
Two, background technology
Chronic tracheitis is the commonly encountered diseases and the frequently-occurring disease of elderly population, improves the cure rate of chronic tracheitis, has great importance to alleviating old people's sufferings, promoting the well-being of mankind.
The medicine of treatment tracheitis is frequently many on the market, but the course of treatment is long, particularly chronic senile tracheitis relapse rate height.And with product---the TANJING sheet that Radix phytolaccae extract makes, treat tracheitis and have the effect for the treatment of both the principal and secondary aspects of a disease, and the production technology of the raw materials for production pharmacist land extract of conduct " TANJING sheet " does not see that the publicity report was arranged.
Three, summary of the invention
The object of the invention is to provide a kind of short treating period, determined curative effect, and untoward reaction is few, and is cheap, and taking convenience is treated chronic tracheitis, especially treats the production technology of the crude drug Chinese medicinal plant Radix phytolaccae extract of chronic senile tracheitis medicine.
Radix Phytolaccae is the dry root of Phytolaccaceae plant pokeweed Phytolacca acinosa Roxb. or pokeroot Phytolacca americana L..Excavate autumn to time spring, removes fibrous root and silt, is cut into piece or sheet and dries or dry in the shade.The nature and flavor hardship of Radix Phytolaccae, cold; Poisonous.Return lung, spleen, kidney, large intestine channel.Function is the detumescence of relieving oedema or abdominal distension through diuresis or purgation, tonneau two just, detoxicating and resolving stagnation of pathogens.Be used for the treatment of the edema distension, constipation and anuresis; The external treatment carbuncle sore tumefacting virus.
The object of the present invention is achieved like this:
Method 1: ethanol extraction
Get the Chinese medicinal plant Radix Phytolaccae and pulverize, with 95% alcohol reflux five times, each 8 hours, filter, filtrate recycling ethanol makes into Radix Phytolaccae extractum (20 ℃ of proportion 1.15), adds purified water furnishing pasty state (20 ℃ of proportion 1.05～1.1) then in extractum, add sulphuric acid again, making the solution sulfuric acid concentration is 2%--7%, heats little boiling, hydrolysis 8 hours, leave standstill in the hydrolysate impouring equal-volume purified water, promptly have brown precipitation to separate out.Filter collection solids is washed till neutrality with purified water, in 75 ℃～85 ℃ oven dry, pulverizes, and crosses 100 mesh sieves, promptly.
Method 2: purified water extraction
Get the Chinese medicinal plant Radix Phytolaccae and be ground into coarse powder, adding the purification decocting in water carries 2 times, each 2 hours, to filter, filtrate decompression concentrates (500～-600Pa 75～85 ℃) and makes into pasty state (20 ℃ of proportion 1.05～1.1), add sulphuric acid, making the solution sulfuric acid concentration is 2%---7%, heat little boiling, hydrolysis 8 hours, leave standstill in the hydrolysate impouring equal-volume purified water, promptly have brown precipitation to separate out.Filter collection solids is washed till neutrality with purified water, in 75 ℃～85 ℃ oven dry, pulverizes, and crosses 100 mesh sieves, promptly.
The present invention is the production technology of Chinese medicine Radix phytolaccae extract, and the Radix phytolaccae extract of this explained hereafter is brown or brown ceramic powder; Feeble QI, it is little puckery to distinguish the flavor of; Can detect the phytolaccagenic acid methyl ester.
The Radix phytolaccae extract that the present invention produces can directly act on tracheal mucosa, promote that sputum dispelling goes out, strengthen ciliary movement, reduce capillary permeability, alleviate tracheal mucosa swelling, minimizing is oozed out, and can excited hypophysis---adrenal system be arranged by influencing central nervous system's (brain stem), play the expelling phlegm for arresting cough effect, be applicable to the treatment chronic tracheitis, especially the chronic senile tracheitis.
The preparation that the present invention produced---TANJING sheet, every contains Radix phytolaccae extract 15mg.
Four, embodiment
The production technology of Chinese medicinal plant Radix phytolaccae extract provided by the invention,
1, ethanol extraction
Get the Chinese medicinal plant Radix Phytolaccae and pulverize, with 95% alcohol reflux five times, each 8 hours, filter, filtrate recycling ethanol makes into Radix Phytolaccae extractum (20 ℃ of proportion 1.15), adds purified water furnishing pasty state (20 ℃ of proportion 1.05～1.1) then in extractum, add sulphuric acid again, making the solution sulfuric acid concentration is 2%--7%, heats little boiling, hydrolysis 8 hours, leave standstill in the hydrolysate impouring equal-volume purified water, promptly have brown precipitation to separate out.Filter collection solids is washed till neutrality with purified water, in 75 ℃～85 ℃ oven dry, pulverizes, and crosses 100 mesh sieves, promptly.
2, purified water extraction
Get the Chinese medicinal plant Radix Phytolaccae and be ground into coarse powder, adding the purification decocting in water carries 2 times, each 2 hours, to filter, filtrate decompression concentrates (500～-600Pa 75～85 ℃) and makes into pasty state (20 ℃ of proportion 1.05～1.1), add sulphuric acid, making the solution sulfuric acid concentration is 2%---7%, heat little boiling, hydrolysis 8 hours, leave standstill in the hydrolysate impouring equal-volume purified water, promptly have brown precipitation to separate out.Filter collection solids is washed till neutrality with purified water, in 75 ℃～85 ℃ oven dry, pulverizes, and crosses 100 mesh sieves, promptly.
Optimum implementation of the present invention:
Embodiment 1
Get the Radix Phytolaccae 1000kg that has pulverized, add 95% ethanol 1500kg heating and refluxing extraction 8 hours, (reflux, extract, is five times altogether) filter, and filtrate recycling ethanol merges ethanol extract (20 ℃ of proportion 1.15).Add purified water furnishing pasty state (20 ℃ of proportion 1.05～1.1) in extractum, add sulphuric acid again, making the solution sulfuric acid concentration is 2%-7%, heats little boiling water and separates 8 hours, leaves standstill 12 hours in the isopyknic purified water of hydrolysate impouring, promptly has brown precipitation to separate out.Filter collection solids is washed till neutrality with purified water, in 75 ℃～85 ℃ oven dry, pulverizes, and crosses 100 mesh sieves, promptly gets Radix phytolaccae extract 40kg-60kg.
Example 2
Get the Radix Phytolaccae 1000kg that has pulverized, adding purified water 1500kg boils and carries 2 times, each 2 hours, filter, filtrate decompression concentrates (75 ℃-85 ℃ of 500Pa--600Pa) and makes into pasty state (20 ℃ of proportion 1.05-1.1), adds sulphuric acid, making the solution sulfuric acid concentration is 2%-7%, heat little boiling water and separated 8 hours, left standstill 12 hours in the isopyknic purified water of hydrolysate impouring, promptly have brown precipitation to separate out.Filter collection solids is washed till neutrality with purified water, in 75 ℃～85 ℃ oven dry, pulverizes, and crosses 100 mesh sieves, promptly gets Radix phytolaccae extract 40kg-50kg.
Claims (1)
1. the production technology of a Chinese medicinal plant Radix phytolaccae extract is characterized in that:
(1), ethanol extraction
Get the Chinese medicinal plant Radix Phytolaccae and pulverize, with 95% alcohol reflux five times, each 8 hours, filter, filtrate recycling ethanol makes into Radix Phytolaccae extractum (20 ℃ of proportion 1.15), adds purified water furnishing pasty state (20 ℃ of proportion 1.05～1.1) then in extractum, add sulphuric acid again, making the solution sulfuric acid concentration is 2%---7%, heat little boiling, hydrolysis 8 hours, leave standstill in the hydrolysate impouring equal-volume purified water, promptly have brown precipitation to separate out.Filter collection solids is washed till neutrality with purified water, in 75 ℃～85 ℃ oven dry, pulverizes, and crosses 100 mesh sieves, promptly.
(2), purified water extraction
Get the Chinese medicinal plant Radix Phytolaccae and be ground into coarse powder, adding the purification decocting in water carries 2 times, each 2 hours, to filter, filtrate decompression concentrates (500～-600Pa 75～85 ℃) and makes into pasty state (20 ℃ of proportion 1.05～1.1), add sulphuric acid, making the solution sulfuric acid concentration is 2%---7%, heat little boiling, hydrolysis 8 hours, leave standstill in the hydrolysate impouring equal-volume purified water, promptly have brown precipitation to separate out.Filter collection solids is washed till neutrality with purified water, in 75 ℃～85 ℃ oven dry, pulverizes, and crosses 100 mesh sieves, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100184715A CN101112403B (en) | 2007-07-26 | 2007-07-26 | Production technology of Chinese traditional medicine plant pokeweed extract |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100184715A CN101112403B (en) | 2007-07-26 | 2007-07-26 | Production technology of Chinese traditional medicine plant pokeweed extract |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201010221187XA Division CN102008517B (en) | 2007-07-26 | 2007-07-26 | Process for producing traditional Chinese herbal medicine pokeberry root extract with purified water |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101112403A true CN101112403A (en) | 2008-01-30 |
| CN101112403B CN101112403B (en) | 2010-12-29 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007100184715A Expired - Fee Related CN101112403B (en) | 2007-07-26 | 2007-07-26 | Production technology of Chinese traditional medicine plant pokeweed extract |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102002090A (en) * | 2010-11-23 | 2011-04-06 | 苏州派腾生物医药科技有限公司 | Preparation method of Ombuoside H |
| CN102127309A (en) * | 2010-12-10 | 2011-07-20 | 盐城纺织职业技术学院 | Preparation method and application of natural plant dye solution of Phytolacca acinosa berries |
| EP2494868A4 (en) * | 2009-10-26 | 2015-03-11 | Ciencia Intra Vegetal S L | Method for the extraction and hydrolysis of any protein substance, natural auxins and polyphenols from sources of plant origin, and resulting product |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1397563A (en) * | 2002-08-20 | 2003-02-19 | 上海宇盛科技有限公司 | Process for preparing phytolaccae antivirus protein |
-
2007
- 2007-07-26 CN CN2007100184715A patent/CN101112403B/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2494868A4 (en) * | 2009-10-26 | 2015-03-11 | Ciencia Intra Vegetal S L | Method for the extraction and hydrolysis of any protein substance, natural auxins and polyphenols from sources of plant origin, and resulting product |
| CN102002090A (en) * | 2010-11-23 | 2011-04-06 | 苏州派腾生物医药科技有限公司 | Preparation method of Ombuoside H |
| CN102002090B (en) * | 2010-11-23 | 2012-10-03 | 苏州派腾生物医药科技有限公司 | Preparation method of Ombuoside H |
| CN102127309A (en) * | 2010-12-10 | 2011-07-20 | 盐城纺织职业技术学院 | Preparation method and application of natural plant dye solution of Phytolacca acinosa berries |
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| Publication number | Publication date |
|---|---|
| CN101112403B (en) | 2010-12-29 |
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Granted publication date: 20101229 Termination date: 20180726 |