CN104288601A - Skin itching-relieving ointment and preparation method thereof - Google Patents
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Abstract
The invention discloses a skin itching-relieving ointment and a preparation method thereof. The skin itching-relieving ointment consists of the following components in parts by mass: 20-30 parts of red beans, 20-30 parts of the seed of pearl barley, 20-40 parts of radix sophorae flavescentis, 10-20 parts of fructus cnidii, 10-20 parts of fructus forsythiae, 30-50 parts of liquorice, 4-8 parts of common andrographis herb and 2-5 parts of borneol. The preparation method comprises the following steps: weighing the medicinal materials according to the mass parts, respectively extracting volatile oil from the fructus cnidii and fructus forsythia, decocting the decoction dregs obtained after the volatile oil is extracted from the fructus cnidii and fructus forsythia, the red beans, pearl barley, radix sophorae flavescentis, liquorice and common andrographis herb in water, filtering, concentrating, drying, grinding, crushing the borneol, mixing to be uniform, adding white Vaseline, mixing to be uniform, thereby obtaining the skin itching-relieving ointment. The skin itching-relieving ointment disclosed by the invention is simple in preparation method, convenient to use and good in transdermal absorption and does not have any toxic or side effect, and the effective rate is 98 percent.
Description
Technical field
The present invention relates to technical field of Chinese medicine, particularly a kind of skin antipruritic ointment and preparation method thereof.
Background technology
Skin pruritus is modal disease in Dermatology Outpatient Department, and will only have skin pruritus and be referred to as pruritus without primary cutaneous impairer clinically, the traditional Chinese medical science be referred to as pruritus caused by wind pathogen, belongs to the category of the traditional Chinese medical science " pruritus ".Main manifestations is that xerosis cutis, desquamation, pruritus are immoderate, can occur skin ulceration and many places scratch, blood crusts because repeatedly scratching.
A lot of skin disease is if psoriasis, fungal infection of hand and foot, brothers' tinea corporis and cruris, eczema, dermatitis etc. are all with the symptom such as skin pruritus and pain.It is reported ill more and more of skin pruritus at present caused by a variety of causes, and morbidity is frequent, although skin pruritus can not bring serious harm, but these symptoms also can affect the life of people, work and health, also patient can be caused to have a sleepless night, depressed etc., therefore should attach the importance for skin pruritus.
Clinically, adult is more common in the performance of general pruritus, and pruritus Chang Congyi place starts, and expands to whole body gradually.Normal be paroxysmal, and especially to attach most importance to night, severe patient be that persistence pruritus companion paroxysmal is aggravated, and drinks, coffee, tea, emotion changes, the stimulation of pungent diet, mechanicalness are scratched, warm bedding, even certain hint can impel the outbreak of pruritus and increase the weight of., even there is the change of eczema sample, lichenification, pyoderma and lymphangitis and lymphadenitis in Chang Jifa scratch, blood crusts, pigmentation.Pruritus senilis is mainly in old people, often itches most with trunk, and how because of caused by the factors such as sebaceous gland hypofunction, xerosis cutis, female patient may be the one performance of PMS; Pruritus hiemalis is more common in adult, and child also can fall ill.When the multiple Qiu Mo of being born in and winter temperature sharply change, when patient is everlasting and enters warm indoor or undress before sleeping, just start pruritus.Pruritus aestivalis is often that inducement causes pruritus with damp and hot, and perspiration increased pruritus can be made to increase the weight of summer.
The molecular basis relevant with pruritus and pathophysiological mechanism still imperfectly understand at present, though Methods of TCM is many, but external used medicine is less, and traditional Chinese medicine for external application mostly is lotion, powder, oil preparation etc., there is deficiencies such as using inconvenience, Transdermal absorption is poor, easily come off and preparation process Chinese crude drug utilization rate is low.Just there are the problems referred to above in application number inflammation-resisting itch-stopping lotion and application number a kind of Chinese herbal medicine skin antipruritic liquid disclosed in the patent of 200610124816.0 disclosed in the patent of 200510043264.6.
Therefore, high, easy to use, the eutherapeutic external-applied ointment of a kind of safety is studied very urgent and be necessary.
Summary of the invention
The object of the invention is in order to overcome above the deficiencies in the prior art provide a kind of easy to use, Transdermal absorption good, skin antipruritic ointment and preparation method thereof safely and efficiently.
A kind of skin antipruritic ointment of the present invention is made up of the component of following mass fraction: Semen Phaseoli 20-30 part, Semen Coicis 20-30 part, Radix Sophorae Flavescentis 20-40 part, Fructus Cnidii 10-20 part, Fructus Forsythiae 10-20 part, Radix Glycyrrhizae 30-50 part, Herba Andrographis 4-8 part, Borneolum Syntheticum 2-5 part.
Preferably, a kind of skin antipruritic ointment, is made up of the component of following mass fraction: Semen Phaseoli 22-28 part, Semen Coicis 22-28 part, Radix Sophorae Flavescentis 25-35 part, Fructus Cnidii 12-18 part, Fructus Forsythiae 12-18 part, Radix Glycyrrhizae 35-45 part, Herba Andrographis 5-7 part, Borneolum Syntheticum 3-4 part.
Preferred, a kind of skin antipruritic ointment, is made up of each component of following mass fraction: Semen Phaseoli 25 parts, Semen Coicis 25 parts, Radix Sophorae Flavescentis 30 parts, Fructus Cnidii 15 parts, Fructus Forsythiae 15 parts, 40 parts, Radix Glycyrrhizae, Herba Andrographis 6 parts, Borneolum Syntheticum 4 parts.
A preparation method for skin antipruritic ointment, comprises the following steps:
A: medical material is made only: take Semen Phaseoli, Semen Coicis, Radix Sophorae Flavescentis, Fructus Cnidii, Fructus Forsythiae, Radix Glycyrrhizae, Herba Andrographis and Borneolum Syntheticum according to mass fraction, only make;
B: extract volatile oil: Fructus Cnidii and Fructus Forsythiae vapor distillation extract volatile oil respectively;
C: decoct: the medicinal residues that Fructus Cnidii in step b and Fructus Forsythiae extract after volatile oil are decocted with water 2-3 time together with Herba Andrographis with Semen Phaseoli, Semen Coicis, Radix Sophorae Flavescentis, Radix Glycyrrhizae, add the soak by water 2-4 hour of 5-8 times amount at every turn, merging filtrate after filtering, filtrate being concentrated into relative density is 1.2-1.3g/cm
3, obtain concentrated solution, then obtain fine powder after concentrated solution being carried out drying, pulverizing;
D: pulverize: the granularity requirements of Borneolum Syntheticum according to 140-180 micron is pulverized, obtains the Borneolum Syntheticum after pulverizing;
E: cream processed: the Borneolum Syntheticum mix homogeneously after the pulverizing that the fine powder in the volatile oil obtained by step b, step c after concentrated solution drying and crushing and step c obtain, more namely the white vaseline mix homogeneously adding 5-7 times of dose obtains skin antipruritic ointment.
Preferably, 2 times are decocted with water described in step c.
Preferably, the soak by water at every turn adding 5 times amount described in step c 2 hours.
Preferably, the relative density that filtrate is concentrated into described in step c is 1.25g/cm
3.
Relative density described in step c is the density relative to water under the condition of 70 DEG C-80 DEG C.
Preferably, the granularity requirements of Borneolum Syntheticum according to 150 microns is pulverized described in steps d.
Preferably, the white vaseline mix homogeneously adding 5 times of doses again described in step e.
The effect forming each composition of the present invention is described as follows:
Semen Phaseoli: red Semen Phaseoli is used as medicine swollen beriberi, dysentery, the carbuncle of harnessing the river, and be the heat and toxic materials clearing away medicine that relaxes and diuretic; Mash external application after immersion, control various toxic swelling.
Semen Coicis: main arthralgia chiefly caused by damp pathogen, sharp the intestines and stomach, consumer edema, moist skin, whitening is mended wet, except speckle, cool property clearing away heat and removing summer.Kernel is not only excellent nutriment, and has diuresis and antitumaous effect.Be applicable to beriberi edema, the carcinoma initial stage.Its root is for driving ascarid medicine.
Radix Sophorae Flavescentis: bitter, cold, enters liver, kidney, large intestine, small intestine meridian.Heat clearing away, dampness, parasite killing.Control toxic-heat and blood stasis, discharging fresh blood stool, jaundice, leucorrhea with red and white discharge, infantile pneumonia, infantile malnutrition, acute tonsillitis, anal fistula, proctoptosis, skin pruritus, mange malignant boil, erosion of vulva pruritus due to damp pathogen, scrofula, scald.External heat-clearing and toxic substances removing, dampness removing to stop itchin.
Fructus Cnidii: nature and flavor: warm in nature is bitter.Function cures mainly: warming the kidney to invigorate YANG, and dampness is dispeled the wind, parasite killing.For sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago; External treatment vulval eczema, married woman's pudendal pruritus, trichomonal vaginitis.
Fructus Forsythiae: it has antibacterial, antiinflammatory, antipyretic, town is told, diuresis heart tonifying, anti-liver damage, analgesia, suppress the effects such as phosphodiesterase, antiviral, blood pressure lowering, suppression elastin laminin enzyme activity, antiendotoxin.Except fruit medicine, tool heat-clearing and toxic substances removing, disappear outside the effect of knot evacuation of pus, its leaf medicinal, better to effect such as treatment hypertension, dysentery, throat pain etc.
Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, clear throat, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Herba Andrographis: leaf is containing diterpenic lactone: dexyandrographolide and deoxyandrographolide more than 0.1%, andrographolide and andrographolide more than 1.5%, Neoandrographolide and neoandrographolide more than 0.2%; And homoandrographolide, panicolide.Also containing andnrographan, andrographon, phosterin, cupreol-D-Glucose glycoside etc.There is refrigeration function and antiinflammatory action.
Borneolum Syntheticum: arduous, cool.Enter the heart, lung meridian.Logical all keys, loose stagnated fire, removing nebula improving eyesight, reducing swelling and alleviating pain.Control apoplexy locked mouth, calentura coma, infantile convulsion expectorant fan, deafness with qi stagnation, sore throat, aphtha, otitis media, carbuncle, hemorrhoid, order is nebula film also, enterobiasis.
Beneficial effect: itching-relieving cream composition of the present invention is pure Chinese medicine ingredients, and wherein Semen Phaseoli and Semen Coicis are common food materials, make whole formula safer, the property of medicine is gentle, utilize heat-clearing and toxic substances removing, inducing diuresis to remove edema, determined curative effect, have no side effect, effectively can treat and improve the skin pruritus caused by a variety of causes, and with low cost.Preparation method of the present invention is simple, and easy to use, Transdermal absorption is good, and effective percentage reaches 98%.
Skin antipruritic ointment provided by the invention is compared with Chinese medicine antipruritic in prior art, specific as follows:
1, in currently available technology, external used medicine is less, and traditional Chinese medicine for external application mostly is lotion, powder, oil preparation etc., exist and use the deficiencies such as inconvenient, Transdermal absorption is poor, easily come off, and the present invention is paste, directly be applied in affected part, easy to use, and ointment and direct skin contact Transdermal absorption better, and ointment is covered in affected part difficult drop-off after smearing, drug residence time is long.
2, in prior art, the preparation of antipruritic Chinese medicine adopts immersion more, decocts the method extracted, the utilization rate of its medical material is lower, adopts and extract volatile oil in the present invention, then is decocted by the medicinal residues after extracting volatile oil, make use of medical material fully, medical material utilization rate improves 15%-20%.
Detailed description of the invention
Embodiment 1
A kind of skin antipruritic ointment is made up of the component of following mass fraction: Semen Phaseoli 20 parts, Semen Coicis 20 parts, Radix Sophorae Flavescentis 20 parts, Fructus Cnidii 10 parts, Fructus Forsythiae 10 parts, 30 parts, Radix Glycyrrhizae, Herba Andrographis 4 parts, Borneolum Syntheticum 2 parts.
A kind of preparation method of skin antipruritic ointment comprises the following steps:
A: medical material is made only: take Semen Phaseoli, Semen Coicis, Radix Sophorae Flavescentis, Fructus Cnidii, Fructus Forsythiae, Radix Glycyrrhizae, Herba Andrographis and Borneolum Syntheticum according to above-mentioned mass fraction, only make;
B: extract volatile oil: Fructus Cnidii and Fructus Forsythiae vapor distillation extract volatile oil respectively;
C: decoct: the medicinal residues that Fructus Cnidii in step b and Fructus Forsythiae extract after volatile oil are decocted with water 2 times with Semen Phaseoli, Semen Coicis, Radix Sophorae Flavescentis, Radix Glycyrrhizae together with Herba Andrographis, add the soak by water 2 hours of 5 times amount at every turn, merging filtrate after filtering, filtrate being concentrated into relative density is 1.2g/cm
3, obtain concentrated solution, then obtain fine powder after concentrated solution being carried out drying, pulverizing;
D: pulverize: the granularity requirements of Borneolum Syntheticum according to 140 microns is pulverized, obtains the Borneolum Syntheticum after pulverizing;
E: cream processed: the Borneolum Syntheticum mix homogeneously after the pulverizing that the fine powder in the volatile oil obtained by step b, step c after concentrated solution drying and crushing and step c obtain, more namely the white vaseline mix homogeneously adding 5 times of doses obtains skin antipruritic ointment.
Relative density described in step c is the density relative to water under the condition of 80 DEG C.
Embodiment 2
A kind of skin antipruritic ointment is made up of the component of following mass fraction: Semen Phaseoli 30 parts, Semen Coicis 30 parts, Radix Sophorae Flavescentis 40 parts, Fructus Cnidii 20 parts, Fructus Forsythiae 20 parts, 50 parts, Radix Glycyrrhizae, Herba Andrographis 8 parts, Borneolum Syntheticum 5 parts.
A kind of preparation method of skin antipruritic ointment comprises the following steps:
A: medical material is made only: take Semen Phaseoli, Semen Coicis, Radix Sophorae Flavescentis, Fructus Cnidii, Fructus Forsythiae, Radix Glycyrrhizae, Herba Andrographis and Borneolum Syntheticum according to above-mentioned mass fraction, only make;
B: extract volatile oil: Fructus Cnidii and Fructus Forsythiae vapor distillation extract volatile oil respectively;
C: decoct: the medicinal residues that Fructus Cnidii in step b and Fructus Forsythiae extract after volatile oil are decocted with water 3 times with Semen Phaseoli, Semen Coicis, Radix Sophorae Flavescentis, Radix Glycyrrhizae together with Herba Andrographis, add the soak by water 4 hours of 8 times amount at every turn, merging filtrate after filtering, filtrate being concentrated into relative density is 1.3g/cm
3, obtain concentrated solution, then obtain fine powder after concentrated solution being carried out drying, pulverizing;
D: pulverize: the granularity requirements of Borneolum Syntheticum according to 180 microns is pulverized, obtains the Borneolum Syntheticum after pulverizing;
E: cream processed: the Borneolum Syntheticum mix homogeneously after the pulverizing that the fine powder in the volatile oil obtained by step b, step c after concentrated solution drying and crushing and step c obtain, more namely the white vaseline mix homogeneously adding 7 times of doses obtains skin antipruritic ointment.
Relative density described in step c is the density relative to water under the condition of 80 DEG C.
Embodiment 3
A kind of skin antipruritic ointment is made up of the component of following mass fraction: Semen Phaseoli 22 parts, Semen Coicis 22 parts, Radix Sophorae Flavescentis 25 parts, Fructus Cnidii 12 parts, Fructus Forsythiae 12 parts, 35 parts, Radix Glycyrrhizae, Herba Andrographis 5 parts, Borneolum Syntheticum 3 parts.
A kind of preparation method of skin antipruritic ointment comprises the following steps:
A: medical material is made only: take Semen Phaseoli, Semen Coicis, Radix Sophorae Flavescentis, Fructus Cnidii, Fructus Forsythiae, Radix Glycyrrhizae, Herba Andrographis and Borneolum Syntheticum according to above-mentioned mass fraction, only make;
B: extract volatile oil: Fructus Cnidii and Fructus Forsythiae vapor distillation extract volatile oil respectively;
C: decoct: the medicinal residues that Fructus Cnidii in step b and Fructus Forsythiae extract after volatile oil are decocted with water 2 times with Semen Phaseoli, Semen Coicis, Radix Sophorae Flavescentis, Radix Glycyrrhizae together with Herba Andrographis, add the soak by water 3 hours of 6 times amount at every turn, merging filtrate after filtering, filtrate being concentrated into relative density is 1.2g/cm
3, obtain concentrated solution, then obtain fine powder after concentrated solution being carried out drying, pulverizing;
D: pulverize: the granularity requirements of Borneolum Syntheticum according to 150 microns is pulverized, obtains the Borneolum Syntheticum after pulverizing;
E: cream processed: the Borneolum Syntheticum mix homogeneously after the pulverizing that the fine powder in the volatile oil obtained by step b, step c after concentrated solution drying and crushing and step c obtain, more namely the white vaseline mix homogeneously adding 6 times of doses obtains skin antipruritic ointment.
Relative density described in step c is the density relative to water under the condition of 70 DEG C.
Embodiment 4
A kind of skin antipruritic ointment is made up of the component of following mass fraction: Semen Phaseoli 28 parts, Semen Coicis 28 parts, Radix Sophorae Flavescentis 35 parts, Fructus Cnidii 18 parts, Fructus Forsythiae 18 parts, 45 parts, Radix Glycyrrhizae, Herba Andrographis 7 parts, Borneolum Syntheticum 4 parts.
A kind of preparation method of skin antipruritic ointment comprises the following steps:
A: medical material is made only: take Semen Phaseoli, Semen Coicis, Radix Sophorae Flavescentis, Fructus Cnidii, Fructus Forsythiae, Radix Glycyrrhizae, Herba Andrographis and Borneolum Syntheticum according to above-mentioned mass fraction, only make;
B: extract volatile oil: Fructus Cnidii and Fructus Forsythiae vapor distillation extract volatile oil respectively;
C: decoct: the medicinal residues that Fructus Cnidii in step b and Fructus Forsythiae extract after volatile oil are decocted with water 2 times with Semen Phaseoli, Semen Coicis, Radix Sophorae Flavescentis, Radix Glycyrrhizae together with Herba Andrographis, add the soak by water 3 hours of 5 times amount at every turn, merging filtrate after filtering, filtrate being concentrated into relative density is 1.25g/cm
3, obtain concentrated solution, then obtain fine powder after concentrated solution being carried out drying, pulverizing;
D: pulverize: the granularity requirements of Borneolum Syntheticum according to 150 microns is pulverized, obtains the Borneolum Syntheticum after pulverizing;
E: cream processed: the Borneolum Syntheticum mix homogeneously after the pulverizing that the fine powder in the volatile oil obtained by step b, step c after concentrated solution drying and crushing and step c obtain, more namely the white vaseline mix homogeneously adding 5 times of doses obtains skin antipruritic ointment.
Relative density described in step c is the density relative to water under the condition of 70 DEG C.
Embodiment 5
A kind of skin antipruritic ointment is made up of the component of following mass fraction: Semen Phaseoli 25 parts, Semen Coicis 25 parts, Radix Sophorae Flavescentis 30 parts, Fructus Cnidii 15 parts, Fructus Forsythiae 15 parts, 40 parts, Radix Glycyrrhizae, Herba Andrographis 6 parts, Borneolum Syntheticum 4 parts.
A kind of preparation method of skin antipruritic ointment comprises the following steps:
A: medical material is made only: take Semen Phaseoli, Semen Coicis, Radix Sophorae Flavescentis, Fructus Cnidii, Fructus Forsythiae, Radix Glycyrrhizae, Herba Andrographis and Borneolum Syntheticum according to above-mentioned mass fraction, only make;
B: extract volatile oil: Fructus Cnidii and Fructus Forsythiae vapor distillation extract volatile oil respectively;
C: decoct: the medicinal residues that Fructus Cnidii in step b and Fructus Forsythiae extract after volatile oil are decocted with water 2 times with Semen Phaseoli, Semen Coicis, Radix Sophorae Flavescentis, Radix Glycyrrhizae together with Herba Andrographis, add the soak by water 4 hours of 6 times amount at every turn, merging filtrate after filtering, filtrate being concentrated into relative density is 1.25g/cm
3, obtain concentrated solution, then obtain fine powder after concentrated solution being carried out drying, pulverizing;
D: pulverize: the granularity requirements of Borneolum Syntheticum according to 150 microns is pulverized, obtains the Borneolum Syntheticum after pulverizing;
E: cream processed: the Borneolum Syntheticum mix homogeneously after the pulverizing that the fine powder in the volatile oil obtained by step b, step c after concentrated solution drying and crushing and step c obtain, more namely the white vaseline mix homogeneously adding 5 times of doses obtains skin antipruritic ointment.
Relative density described in step c is the density relative to water under the condition of 70 DEG C.
Clinical practice efficacy analysis:
Clinical data: the routine skin pruritus patient of clinical Stochastic choice 200.
Consumption: being applied in affected part, every day 3-4 time when itching-relieving cream of the present invention uses, 3 days is 1 course for the treatment of.
Therapeutic effect: use itching-relieving cream of the present invention to treat 200 examples altogether, effective 196 examples, invalid 4 examples, total effective rate 98%.
Again the skin antipruritic ointment of preparation in embodiment 1 to embodiment 5 is carried out clinical trial relative analysis, analysis of experiments result is as shown in table 1.
Table 1
| ? | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| Total effective rate | 97.3% | 97.5% | 96.9% | 97.8% | 98.0% |
| Itch the transference cure time | 3 days | 4 days | 2 days | 4 days | 2 days |
From clinical trial relative analysis result table 1, the clinical effectiveness of skin antipruritic ointment prepared by embodiment 5 is best.
Model case:
1, Lee, female, 26 years old, lives Wuhan City.Lower limb both legs have the red rash point differed in size, and with sufferings, patient's sufferings are hard to bear, upset.
Skin antipruritic ointment described in Example 1, is applied to affected part, every day 4 times.Sufferings transference cure after 3 days, continue use after 5 days rash point fade away, after continuing two six days courses for the treatment of of use, skin symptom disappears completely.
2, Xu certain, man, 34 years old, live Zibo City.Suffer from beriberi, full human hair combing waste is itched heating, and foot odor is serious.
Skin antipruritic ointment described in Example 2, is applied to affected part, every day 4 times.Itch after 4 days heating paresthesia disappear, continue use after 7 days skin symptom disappear.
3, money, female, 45 years old, lives Weihai City.Because insect bite causes dermatitis, patient very itches hard to bear, dysphoria.
Skin antipruritic ointment described in Example 3, is applied to affected part, every day 3 times.Symptom of itching after 2 days fades away, and continues use skin symptom disappearance after 2 days.
4, Zhao, man, 42 years old, lives Lianyungang.Suffer from psoriasis, head, extremity and trunk all have skin lesion, very itch, and have obvious scratch.
Skin antipruritic ointment described in Example 4, is applied to affected part, every day 4 times.To itch after 4 days transference cure, continue use after 5 days skin lesion reduce, symptom of itching does not recur.
5, week certain, man, 66 years old, live Changsha.Suffer from senile pruritus, lower limb have obvious scratch.
Skin antipruritic ointment described in Example 5, is applied to affected part, every day 3 times.To itch after 2 days transference cure, continue use and cure after 4 days, not recurrence.
Claims (10)
1. a skin antipruritic ointment, is characterized in that being made up of the component of following mass fraction: Semen Phaseoli 20-30 part, Semen Coicis 20-30 part, Radix Sophorae Flavescentis 20-40 part, Fructus Cnidii 10-20 part, Fructus Forsythiae 10-20 part, Radix Glycyrrhizae 30-50 part, Herba Andrographis 4-8 part, Borneolum Syntheticum 2-5 part.
2. a kind of skin antipruritic ointment according to claim 1, is characterized in that being made up of the component of following mass fraction: Semen Phaseoli 22-28 part, Semen Coicis 22-28 part, Radix Sophorae Flavescentis 25-35 part, Fructus Cnidii 12-18 part, Fructus Forsythiae 12-18 part, Radix Glycyrrhizae 35-45 part, Herba Andrographis 5-7 part, Borneolum Syntheticum 3-4 part.
3. a kind of skin antipruritic ointment according to claim 1, is characterized in that being made up of the component of following mass fraction: Semen Phaseoli 25 parts, Semen Coicis 25 parts, Radix Sophorae Flavescentis 30 parts, Fructus Cnidii 15 parts, Fructus Forsythiae 15 parts, 40 parts, Radix Glycyrrhizae, Herba Andrographis 6 parts, Borneolum Syntheticum 4 parts.
4. a preparation method for the skin antipruritic ointment as described in any one of claims 1 to 3, is characterized in that comprising the following steps:
A: medical material is made only: take Semen Phaseoli, Semen Coicis, Radix Sophorae Flavescentis, Fructus Cnidii, Fructus Forsythiae, Radix Glycyrrhizae, Herba Andrographis and Borneolum Syntheticum according to mass fraction, only make;
B: extract volatile oil: Fructus Cnidii and Fructus Forsythiae vapor distillation extract volatile oil respectively;
C: decoct: the medicinal residues that Fructus Cnidii in step b and Fructus Forsythiae extract after volatile oil are decocted with water 2-3 time together with Herba Andrographis with Semen Phaseoli, Semen Coicis, Radix Sophorae Flavescentis, Radix Glycyrrhizae, add the soak by water 2-4 hour of 5-8 times amount at every turn, merging filtrate after filtering, filtrate being concentrated into relative density is 1.2-1.3g/cm
3, obtain concentrated solution, then obtain fine powder after concentrated solution being carried out drying, pulverizing;
D: pulverize: the granularity requirements of Borneolum Syntheticum according to 140-180 micron is pulverized, obtains the Borneolum Syntheticum after pulverizing;
E: cream processed: the Borneolum Syntheticum mix homogeneously after the pulverizing that the fine powder in the volatile oil obtained by step b, step c after concentrated solution drying and crushing and step c obtain, more namely the white vaseline mix homogeneously adding 5-7 times of dose obtains skin antipruritic ointment.
5., according to the preparation method of a kind of skin antipruritic ointment described in claim 4, it is characterized in that decocting with water 2 times described in step c.
6., according to the preparation method of a kind of skin antipruritic ointment described in claim 4, it is characterized in that the soak by water at every turn adding 5 times amount described in step c 2 hours.
7., according to the preparation method of a kind of skin antipruritic ointment described in claim 4, it is characterized in that the relative density that filtrate is concentrated into described in step c is 1.25g/cm
3.
8., according to the preparation method of a kind of skin antipruritic ointment described in claim 4, it is characterized in that the relative density described in step c is the density relative to water under the condition of 70 DEG C-80 DEG C.
9., according to the preparation method of a kind of skin antipruritic ointment described in claim 4, it is characterized in that the granularity requirements of Borneolum Syntheticum according to 150 microns being pulverized described in steps d.
10., according to the preparation method of a kind of skin antipruritic ointment described in claim 4, it is characterized in that the white vaseline mix homogeneously adding 5 times of doses again described in step e.
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| CN104922534A (en) * | 2015-05-31 | 2015-09-23 | 陆仲新 | Externally-applied traditional Chinese medicine for treating infantile eczema and preparation method thereof |
| CN104984100A (en) * | 2015-06-18 | 2015-10-21 | 江苏奇力康皮肤药业有限公司 | Skin calming itching relieving ointment and preparation thereof |
| CN104997687A (en) * | 2015-07-29 | 2015-10-28 | 江苏奇力康皮肤药业有限公司 | Itch reliving and sebum controlling liquid foundation and preparation method thereof |
| CN106138219A (en) * | 2016-07-01 | 2016-11-23 | 扬州中汇生物技术有限公司 | A kind of infant itching-relieving cream and preparation method thereof |
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| CN104922534A (en) * | 2015-05-31 | 2015-09-23 | 陆仲新 | Externally-applied traditional Chinese medicine for treating infantile eczema and preparation method thereof |
| CN104984100A (en) * | 2015-06-18 | 2015-10-21 | 江苏奇力康皮肤药业有限公司 | Skin calming itching relieving ointment and preparation thereof |
| CN104997687A (en) * | 2015-07-29 | 2015-10-28 | 江苏奇力康皮肤药业有限公司 | Itch reliving and sebum controlling liquid foundation and preparation method thereof |
| CN106138219A (en) * | 2016-07-01 | 2016-11-23 | 扬州中汇生物技术有限公司 | A kind of infant itching-relieving cream and preparation method thereof |
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