CN101361790A - Medicine for treating dermatitis eczema, pruritus due to mosquito bites and use thereof - Google Patents
Medicine for treating dermatitis eczema, pruritus due to mosquito bites and use thereof Download PDFInfo
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Abstract
The invention discloses a medicine for treating pruritus caused by dermatitis, eczema and insect bite, and applications thereof. The medicine is a preparation prepared by the following components according to weight percentage: 0.1 percent to 90 percent of glycyrrhizic acid or physically acceptable salt of glycyrrhizic acid or glycyrrhetic acid or physically acceptable salt of glycyrrhetic acid, 0 percent to 90 percent of total matrines or physically acceptable salt of total matrines or oxymatrine or physically acceptable salt of oxymatrine or matrine or physically acceptable salt of matrine, 0 percent to 90 percent of hibiscus syriacus acid or physically acceptable salt of hibiscus syriacus acid or pseudolaric acid B or physically acceptable salt of pseudolaric acid B or osthole or total coumarins of fructus cnidii, and 1 percent to 5 percent of menthol or borneol. The medicine has the effect of anti-inflammatory, bacteriostasis and relieving itching, has unique therapeutic effect on pruritus caused by dermatitis, eczema and insect bite. The raw materials used by the medicine are nontoxic and cheap with low cost.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and purposes, particularly relate to a kind of treatment dermatitis and eczema, pruritus due to mosquito bites medicine and purposes.
Background technology
Eczema is to have an inflammatory skin disease of obviously oozing out tendency by what multiple internal and external factor caused, is a kind of dermatosis of common pilosity.Its clinical characters is the pleomorphism erythra, and the tendency of oozing out is arranged, and is symmetrically distributed, and chronic phase has soaks into and plumpness, and conscious violent pruritus, the state of an illness can not heal easily repeatedly for many years.Dermatitis, eczema are mentioned together through regular meeting, because they are that the cardinal symptom of dermatitis, eczema is pruritus, erythema to the description of same class disease different angles.But dermatitis, eczema still are distinguishing.Clinical so-called dermatitis is meant that the cause of disease is clear and definite or has the eczema of some feature.The dermatitis majority can be found etiology, as contact dermatitis, and the contacted as article such as paint, metal accessory of premorbid.Yet eczema may temporarily be can not check etiology, in case find the cause of disease, renames as so-and-so dermatitis.The disease of eczema is owing to its sickness rate height, and the course of disease is long in addition, easily outbreak repeatedly, even do not heal all the life (as atopic eczema), thereby the morbidity crowd is very extensive.In addition, various contact dermatitis, allergic dermatitis, seborrheic dermatitis etc. show as subacute and chronic eczema sample dermatitis because of repetitious stimulation also very easily forms eczematization.
According to the course of disease and skin lesion characteristics, eczema generally can be divided into acute, subacute, chronic three classes.Acute eczema: from the beginning of being erythema, connecting erythema then and reach pimple and the herpes that occurs grain of rice size on every side, normal intensive in blocks, the substrate flushing has slight prisoner swollen.Because the affected part itches very much, can grab because of scabies and make the herpes flowing water that breaks, very easily take place rotten to the corn, the incrustation of dry back; If pustule can take place in rotten to the corn postoperative infection, sick damage place, pus can ooze out and with regional glandular enlargement, what have also can merge folliculitis or cyst.Chronic eczema: mostly be acute eczema and show effect repeatedly and transfer chronic eczema to, it is slightly thick to show as pars affecta skin, the dry tack free desquamation, erythema is kermesinus, meet heat or when sleeping pruritus increase the weight of.Because often scratch, scald etc., can there be phenomenons such as redness, flowing water in the affected part.The course of disease is indefinite, and recurrence can prolongedly not healed easily.Subacute eczema: between acute and chronic between, promptly have acute part symptom that chronic performance is also arranged.
Happening part and characteristic according to eczema, be called again: ear eczema, newborn portion eczema, umbilical part eczema, eczema scrotum, anal eczema, hand eczema and legs eczema etc. are called infectious eczematoid dermatitis, infantile eczema and autosensitization dermatitis etc. again by its characteristic.Be found in any age, man, woman all can fall ill asexuality difference.Especially patients with chronic eczema is oozed out erosion, pimple, vesicle, squama, knot is silly or plump, violent pruritus; The course of disease is shown effect very easily repeatedly, and follows paroxysmal very to itch, and makes patient's body and mind feel more painful.The global sickness rate of eczema is up to 20%, and also is not less than 15% in China; Particularly southern area is through moisture with damp and hot, and the eczema sickness rate is higher, accounts for the 15%-25% of department of dermatologry outpatient service amount.
In sum, what eczema was fallen ill extensively has some idea of, thereby this type of patient's local topical is treated, and seems particularly important.The medicine of state's such disease of internal therapy is many at present, and the Therapeutic Principle of subacute stage is antiinflammatory, antipruritic, can select Calamine Lotion, glucocorticoids Emulsion, cream for curing eczema etc. for use; The treatment of chronic phase is absorbed as the master with antipruritic, promotion corium inflammation, can select Pityrol ointment, cream for curing eczema, Eloson ointment, glucocorticoids ointment etc. for use; But it is not good enough according to its curative effect of the equal thoughts of clinical investigation, with the back recurrence is arranged more, can not cure fully, patient has stronger dependency to medicine, very easily recurrence after the drug withdrawal, its reason be since in this class medicine all more or less meeting contain the hormones composition, the glucocorticoid external can reduce capillary permeability, minimizing is oozed out, and antiinflammatory and itching relieving effect are arranged.But the external glucocorticoid can only the short-term medication, and strict restriction consumption, and long-term external glucocorticoid can cause local skin atrophy, telangiectasis, acne and folliculitis etc., therefore, and the unsuitable long-term prescription of face and baby.Long-term a large amount of external glucocorticoid also can cause the general untoward reaction.Therefore the recurrence of the course of disease is unsurmountable problem, also is the critical problem that this disease of eczema heals than refractory.For chronic eczema, the past often helps with compound recipe pine tar ointment or coal tar preparation, because of curative effect limited, and easy pollution clothes, also few using.Some the court's preparations of each hospital, as preparations such as zinc oils, the problems referred to above still fail thoroughly to solve.It is investigated that new result sees, the Chinese medicine for outer use that really is used for the treatment of eczema at present is few, and Cortex Phellodendri ointment, dermatitis curative ointment are only arranged, it is less that the two is used for clinical routine number, do not establish matched group, also do not make toxicological test, only in institute, do the clinic trial stage, also do not declare problem by the new drug requirement.Thus, the external preparation of rare in the market treatment by Chinese herbs eczema.
Because eczema morbidity extensively, annual human and material resources, the financial resources that drop into of country are quite a lot of, and primary disease extremely torments the people, have a strong impact on patient's operate as normal and study.Bring serious harm for patient's physical and mental health. therefore, it is good to research and develop a kind of antipruritic effect, and the skin lesion that disappears is fast, and is difficult for recurrence, and pollution clothes not can be saved the cheap eczema external preparation of natural resources of Chinese medicinal materials again, has very major and immediate significance.
The medicine of pruritus due to mosquito bites is also rare on market.
Summary of the invention
The objective of the invention is to overcome deficiency of the prior art, a kind of treatment dermatitis and eczema, pruritus due to mosquito bites medicine are provided.
Second purpose of the present invention provides a kind of purposes that dermatitis and eczema, mosquito bite cause the pruritus medicine for the treatment of.
Technical scheme of the present invention is summarized as follows:
A kind of treatment dermatitis and eczema, pruritus due to mosquito bites medicine, the medicament of making by following component by weight percentage: the physiologically acceptable salt of glycyrrhizic acid or glycyrrhizic acid or the physiologically acceptable salt 0.1%～90% of enoxolone or enoxolone, the physiologically acceptable salt 0%～90% of the physiologically acceptable salt of Radix Sophorae Flavescentis total alkaloids or Radix Sophorae Flavescentis total alkaloids or the physiologically acceptable salt of oxymatrine or oxymatrine or matrine or matrine, the physiologically acceptable salt of rose of Sharon acid or rose of Sharon acid or the physiologically acceptable salt of corter pseudolaricis acetic acid or corter pseudolaricis acetic acid or osthole or Fructus Cnidii total coumarins 0%～90%, menthol or Borneolum Syntheticum 1%～5%.
The physiologically acceptable salt of preferably described glycyrrhizic acid or glycyrrhizic acid or the physiologically acceptable salt of enoxolone or enoxolone are 0.1%-10%.
The physiologically acceptable salt of the physiologically acceptable salt of described Radix Sophorae Flavescentis total alkaloids or Radix Sophorae Flavescentis total alkaloids or the physiologically acceptable salt of oxymatrine or oxymatrine or matrine or matrine is 0.1%-10%.
The physiologically acceptable salt of described rose of Sharon acid or rose of Sharon acid or the physiologically acceptable salt of corter pseudolaricis acetic acid or corter pseudolaricis acetic acid or osthole or Fructus Cnidii total coumarins are 0.1%-10%.
Described menthol or Borneolum Syntheticum are 1%-3%.
Described medicament is solution, membrane, gel or ointment.Preferred ointment.
A kind of dermatitis and eczema, mosquito bite for the treatment of causes the application of pruritus medicine in preparation treatment dermatitis and eczema, pruritus due to mosquito bites medicine.
A kind of medicine for the treatment of dermatitis and eczema, pruritus due to mosquito bites of the present invention is the pure Chinese medicine for external application that does not contain hormone, be directed to the disease of eczema and the characteristics of pruritus due to mosquito bites and have antiinflammatory, antibacterial, itching relieving effect, unique curative effect is arranged for dermatitis and eczema and pruritus due to mosquito bites.The advantages of nontoxic raw materials that this product is used, low price, with low cost.
The specific embodiment
The active selection principle of drug target of the present invention is that the disease characteristics according to foundation dermatitis and eczema class skin injury design drug regimen targetedly.Eczema is a kind of inflammatory skin disease of obviously oozing out tendency that has; And its microorganism recall rate is apparently higher than normal skin, and main bacteria is a staphylococcus aureus, shows that dermatitis and eczema and some antibacterial, fungus, especially staphylococcus aureus are relevant.Therefore we have selected triterpene saponin constituents glycyrrhizic acid or enoxolone or this medicine with higher anti-inflammatory activity of their physiologically acceptable salt in the Radix Glycyrrhizae, be equipped with simultaneously have antiinflammatory, antibacterial, the osthole of itching-relieving action, corter pseudolaricis acetic acid, alkaloid of sophora flavescens ait, obvious at the therapeutic effect of dermatitis and eczema.
The following examples can make those skilled in the art more fully understand the present invention, but do not limit the present invention in any way.
Used effective ingredient and effective site have commercially availablely among the present invention, or can reach in accordance with known methods to describe in the document and prepare.
Embodiment 1
A kind ofly treat the medication preparation that dermatitis and eczema, mosquito bite cause pruritus:
Glycyrrhizic acid 10g, matrine 10g, menthol 1g, ointment base an amount of (glyceryl monostearate 60g, vaseline 40g, hexadecanol 30g, liquid wax 4g, glycerol 70g, Arlacel-60, tween 80, azone, antiseptic, essence an amount of)
Glyceryl monostearate 60g, vaseline 40g, hexadecanol 30g, liquid wax 4g, Arlacel-60 are put into beaker together and mixed, and heating in water bath is to 80-90 ℃ of fusion.Glycyrrhizic acid adds sneaks into oil phase after an amount of ethanol dissolves fully, waves the ethanol that looses to there not being the alcohol flavor.
Glycerol 70g, tween 80, matrine 10g add in the Purified Water, are heated to 70-80 ℃.Under continuous stirring condition, water slowly is added in the oil phase, stop to heat, when being cooled to 60 ℃ of left and right sides, under constantly stirring, adding azone, antiseptic continuation stirring, adding menthol and essence stirred evenly when temperature was reduced to 40-50 ℃, made ointment.
Aspect the preparation of ointment; this prescription mainly is the disease that is used for treating skin aspects such as eczema; so just require ointment to have medicine releasability and skin penetration preferably; and require ointment to form protective layer at wound surface; and ointment is wanted easy cleaning, so we have prepared 0/W (oil/water) type ointment.
Embodiment 2
A kind ofly treat the medication preparation that dermatitis and eczema, mosquito bite cause pruritus:
Enoxolone ammonium 10g, matrine 10g, Borneolum Syntheticum 0.5g, ointment base an amount of (glyceryl monostearate 60g, vaseline 40g, hexadecanol 30g, liquid wax 4g, glycerol 70g, Arlacel-60, tween 80, azone, antiseptic, essence an amount of)
Glyceryl monostearate 60g, vaseline 40g, hexadecanol 30g, liquid wax 4g, Arlacel-60 are put into beaker together and mixed, and heating in water bath is to 80-90 ℃ of fusion.Enoxolone adds sneaks into oil phase after an amount of ethanol dissolves fully, waves the ethanol that looses to there not being the alcohol flavor.
Glycerol 70g, tween 80, matrine 10g add in the Purified Water, are heated to 70-80 ℃.Under continuous stirring condition, water slowly is added in the oil phase, stop to heat, when being cooled to 60 ℃ of left and right sides, under constantly stirring, adding azone, antiseptic continuation stirring, adding menthol and essence stirred evenly when temperature was reduced to 40-50 ℃, made ointment.
Embodiment 3
A kind ofly treat the medication preparation that dermatitis and eczema, mosquito bite cause pruritus:
Diammonium glycyrrhizinate 10g, osthole 10g, Borneolum Syntheticum 0.5g, ointment base an amount of (glyceryl monostearate 60g vaseline 40g, hexadecanol 30g, liquid wax 4g, glycerol 70g, Arlacel-60, tween 80 azone, antiseptic, essence an amount of)
Glyceryl monostearate 60g, vaseline 40g, hexadecanol 30g, liquid wax 4g, Arlacel-60 are put into beaker together and mixed, and heating in water bath is to 80-90 ℃ of fusion.Enoxolone adds sneaks into oil phase after an amount of ethanol dissolves fully, waves the ethanol that looses to there not being the alcohol flavor.
Glycerol 70g, tween 80, Radix Sophorae Flavescentis total alkaloids 10g add in the Purified Water, are heated to 70-80 ℃.Under continuous stirring condition, water slowly is added in the oil phase, stop to heat, when being cooled to 60 ℃ of left and right sides, under constantly stirring, adding azone, antiseptic continuation stirring, adding menthol and essence stirred evenly when temperature was reduced to 40-50 ℃, made ointment.
Embodiment 4
A kind ofly treat the medication preparation that dermatitis and eczema, mosquito bite cause pruritus:
Enoxolone 10g, corter pseudolaricis acetic acid 10g, matrine 5g, Borneolum Syntheticum 0.5g, ointment base an amount of (glyceryl monostearate 60g, vaseline 40g, hexadecanol 30g, liquid wax 4g, glycerol 70g, Arlacel-60, tween 80, azone, antiseptic, essence an amount of)
Glyceryl monostearate 60g, vaseline 40g, hexadecanol 30g, liquid wax 4g, Arlacel-60 are put into beaker together and mixed, and heating in water bath is to 80-90 ℃ of fusion.Enoxolone adds sneaks into oil phase after an amount of ethanol dissolves fully, waves the ethanol that looses to there not being the alcohol flavor.
Glycerol 70g, tween 80 Radix Sophorae Flavescentis total alkaloids 10g add in the Purified Water, are heated to 70-80 ℃.Under continuous stirring condition, water slowly is added in the oil phase, stop to heat, when being cooled to 60 ℃ of left and right sides, under constantly stirring, adding azone, antiseptic continuation stirring, adding menthol and essence stirred evenly when temperature was reduced to 40-50 ℃, made ointment.
Embodiment 5
A kind ofly treat the medication preparation that dermatitis and eczema, mosquito bite cause pruritus:
Enoxolone 10g, osthole 1g, matrine 10g, Borneolum Syntheticum 1g, glycerol 10g, polyvinyl alcohol 05-88125g, distilled water an amount of (about 200mL) is got polyvinyl alcohol 05-88 glycerol adding, after the water logging bubble is treated fully dissolving, the heating fusion adds above-mentioned medicine in water-bath, stirs, leave standstill, eliminate bubble, the shop made membrane is made membrane.
Embodiment 6
A kind ofly treat the medication preparation that dermatitis and eczema, mosquito bite cause pruritus:
Monosodium glycyrrhetin 10g, osthole 10g, matrine 10g, menthol 1g, 50% propylene glycol 30g, carbomer 2g.Above-mentioned medicine is added to stir in the mixture of 50% propylene glycol and carbomer promptly makes gel.
Embodiment 7
A kind ofly treat the medication preparation that dermatitis and eczema, mosquito bite cause pruritus:
Enoxolone potassium 10g, osthole 10g, matrine 10g, menthol 1g, with enoxolone potassium, osthole, matrine, menthol and an amount of glycerol, add an amount of distilled water and grind mix homogeneously, add distilled water more gradually to capacity, concentration is as required made solution.
Embodiment 8
A kind ofly treat the medication preparation that dermatitis and eczema, mosquito bite cause pruritus:
Extracting liquorice acid 0.02g, Radix Sophorae Flavescentis total alkaloids 9.78g, rose of Sharon acid sodium 10g, Borneolum Syntheticum 0.2g get the adjuvant identical with embodiment 1 and are prepared into ointment by the method for embodiment 1.
Embodiment 9
A kind ofly treat the medication preparation that dermatitis and eczema, mosquito bite cause pruritus:
Extracting liquorice subacid ammonium 1.38g, oxymatrine 0.02g, rose of Sharon acid ammonium 18g, menthol 0.6g get the adjuvant identical with embodiment 1 and are prepared into ointment by the method for embodiment 1.
Embodiment 10
A kind ofly treat the medication preparation that dermatitis and eczema, mosquito bite cause pruritus:
Extracting liquorice acid diammonium 16.98g, Matrine sulfate. 2g, rose of Sharon acid sodium 0.02g, Borneolum Syntheticum 1g get the adjuvant identical with embodiment 1 and are prepared into ointment by the method for embodiment 1.
Embodiment 11
A kind ofly treat the medication preparation that dermatitis and eczema, mosquito bite cause pruritus:
Extracting liquorice subacid 2g, phosphoric acid oxymatrine 15.4g, osthole total coumarins 2g, Borneolum Syntheticum 0.6g get the adjuvant identical with embodiment 1 and are prepared into ointment by the method for embodiment 1.
Embodiment 12
A kind ofly treat the medication preparation that dermatitis and eczema, mosquito bite cause pruritus:
Extracting liquorice subacid sodium 18g, sulfuric acid oxidation matrine 1g, osthole 0.4g, menthol 0.6g get the adjuvant identical with embodiment 1 and are prepared into ointment by the method for embodiment 1.
Embodiment 13
A kind ofly treat the medication preparation that dermatitis and eczema, mosquito bite cause pruritus:
Extracting liquorice subacid potassium 1.4g, phosphoric acid Radix Sophorae Flavescentis total alkaloids 18g, Borneolum Syntheticum 0.6g get the adjuvant identical with embodiment 1 and are prepared into ointment by the method for embodiment 1.
The pharmacological results
1. anti-inflammatory activity
Test method: with 50 of mices, be divided into 5 groups at random, 10 every group, be respectively negative control group (external-use substrate), the ointment low concentration group of medicine of the present invention, middle concentration group, high concentration group, positive drug control group (compound recipe Piyanping ointment).Respectively get 0.5 gram, be applied in mice two auricular concha two sides, behind coating 1 hour, dimethylbenzene 0.03ml dripped in mouse right ear shell two sides cause inflammation, after 2 hours, the mice dislocation is put to death, take off circular auricle at left and right sides ear symmetry place respectively with diameter 6mm card punch, analytical balance is weighed. and the weight difference of ears is the swelling degree.The results are shown in Table 1.
Table 1 experimental result
The mouse ear acute exudative inflammation that causes of the ointment xylol of the medicine of the present invention of three kinds of concentration all has the obvious suppression effect as a result.
2. antipruritic test
Experimental technique: with 50 of mices, be divided into 5 groups at random, every group 10, be respectively negative control group (external-use substrate), the ointment low concentration group of medicine of the present invention, middle concentration group, the high concentration group, positive drug control group (compound recipe Piyanping ointment), earlier in mouse carotid back depilation 2cmx3cm size, administration respectively after 24 hours: outer substrate 1 gram that is coated with respectively in model group depilation district, positive controls externally coated compound Piyanping ointment 1 restrains, drug ointment agent low concentration group of the present invention, middle concentration group, high concentration group 1 gram is behind the 30min, (4-AP is made into 0.5% solution with normal saline to give every mouse carotid back subcutaneous injection 4-aminopyridine mg/kg, be diluted to 0.01% solution with normal saline before the experiment), observe in the 10min mice immediately and lick the body number of times (the mice appearance is turned one's head repeatedly and licked the behavior at back, both sides, promptly licks precursor reactant, lick body continuously with mice and cause and minibreak occurs, do to lick body and once calculate).Require: licking body, must to lick its depilation district, back (medicine injection place) continuous more than 5 times, and just turning one's head or licking other position does not count; Minibreak requires: need walking, peak with heading, upright or smell shift action such as thing, do not consider time length; Turn one's head, lick hands repeatedly or wash one's face not very pause.The results are shown in Table 2.
Table 2 experimental result:
The medicine of the present invention that the result shows high, normal, basic three kinds of variable concentrations excessively discharges the skin itching that histamine causes to skin mastocyte due to the 4-AP tangible antagonism.
3. bacteriostatic activity
Compositions A glycyrrhizic acid 10g, matrine 10g, corter pseudolaricis acetic acid 0.5g, menthol 0.5g
Compositions B enoxolone 10g, matrine 10g, corter pseudolaricis acetic acid 0.5g, Borneolum Syntheticum 0.5g
Compositions C diammonium glycyrrhizinate 10g, osthole 10g, Borneolum Syntheticum 0.5g
Compositions D enoxolone 10g, osthole 10g, Borneolum Syntheticum 0.5g
Compositions E enoxolone 10g, osthole 1g, matrine 10g, Borneolum Syntheticum 1g
Composition F enoxolone 10g, osthole 10g, matrine 10g, menthol 1g,
3.1 material:
(1) strain: candida albicans bacterium (Candida albicans) 2 strains, Tianjin changzheng Hospital provides; Neogenesis cryptococcus, preserve this chamber.All identify through routine.
(2) culture medium: the husky fluid medium (peptone 1 gram, glucose 4 grams, water 100mL) of protecting, the husky agar culture medium (mentioned component adds agar 2 grams) of protecting.
3.2 method:
(1) gets strain and protect the activation of going down to posterity in the agar culture medium, 37 ℃, cultivated 24 hours at sand.
(2) fungus counting: get a colonies typical and be dissolved in the 1mL physiological saline solution, the vibration mixing with the blood cell counting plate counting, is adjusted into 2 * 10 with concentration
4CFU/mL (2 times of final concentrations).
(3) drug dilution liquid: with the husky fluid medium dilution testing sample of protecting, doubling dilution, concentration is 256-4 μ g/mL, every test tube 1mL.
(4) get 2 times of final concentration bacterium liquid 100 μ L and add the medicine test tube, establish the aseptic contrast of fungus positive control and culture medium simultaneously.
(5) 37 ℃, cultivate 24 hours observed results.
3.3 result:
Under not stirring situation, with culture medium clearly test tube be that bacterial strain 100% is suppressed, the drug level value of this pipe is its MIC (minimum inhibitory concentration), the results are shown in Table 3:
3.4 the preparation of bacterial suspension: strain is chosen a colony inoculation in nutrient broth through twice activation of going down to posterity, 37 ℃, cultivated 24 hours, and to proofread and correct bacterial concentration with normal saline and cause 0.5 Maxwell turbidity standard, reuse MH meat soup 1:10 dilution makes the bacterium amount reach 10
7CFU/mL.Get bacterial suspension 100 μ L and add test tube, establish positive for bacteria contrast and the aseptic contrast of culture medium simultaneously, 37 ℃, cultivate 24 hours observed results.
Table 3 compositions A-F minimum inhibitory concentration (μ g/mL)
4. irritation test
Select 3 of healthy rabbits, body weight is 2.5-3.0kg, and both sides, every rabbit back select a place to shave a mao 2.5cm
2Use the own control test method(s), respectively with medicine of the present invention (embodiment 1 preparation) ointment and each 0.5g of blank substrate, be coated in equably and shave a mao position, 2 times/d, observe and record 24h and 72h after dermoreaction, reactions such as that the result does not all have is rubescent, dermexanthesis, blister, the ointment nonirritant of this medicine of the present invention is described, external safety.
Claims (8)
1. treat dermatitis and eczema for one kind, the pruritus due to mosquito bites medicine is characterized in that the medicament of being made by following component by weight percentage: the physiologically acceptable salt of glycyrrhizic acid or glycyrrhizic acid or the physiologically acceptable salt 0.1%～90% of enoxolone or enoxolone, the physiologically acceptable salt 0%～90% of the physiologically acceptable salt of Radix Sophorae Flavescentis total alkaloids or Radix Sophorae Flavescentis total alkaloids or the physiologically acceptable salt of oxymatrine or oxymatrine or matrine or matrine, the physiologically acceptable salt of rose of Sharon acid or rose of Sharon acid or the physiologically acceptable salt of corter pseudolaricis acetic acid or corter pseudolaricis acetic acid or osthole or Fructus Cnidii total coumarins 0%～90%, menthol or Borneolum Syntheticum 1%～5%.
2. a kind of treatment dermatitis and eczema according to claim 1, pruritus due to mosquito bites medicine is characterized in that the physiologically acceptable salt of described glycyrrhizic acid or glycyrrhizic acid or the physiologically acceptable salt of enoxolone or enoxolone are 0.1%-10%.
3. a kind of treatment dermatitis and eczema according to claim 1, pruritus due to mosquito bites medicine is characterized in that the physiologically acceptable salt of described Radix Sophorae Flavescentis total alkaloids or Radix Sophorae Flavescentis total alkaloids or the physiologically acceptable salt of oxymatrine or oxymatrine or the physiologically acceptable salt of matrine or matrine are 0.1%-10%.
4. a kind of treatment dermatitis and eczema according to claim 1, pruritus due to mosquito bites medicine is characterized in that the physiologically acceptable salt of the physiologically acceptable salt of described rose of Sharon acid or rose of Sharon acid or corter pseudolaricis acetic acid or corter pseudolaricis acetic acid or osthole or Fructus Cnidii total coumarins are 0.1%-10%.
5. a kind of treatment dermatitis and eczema according to claim 1, pruritus due to mosquito bites medicine is characterized in that described menthol or Borneolum Syntheticum are 1%-3%.
6. according to the described a kind of treatment dermatitis and eczema of one of claim 1-5, pruritus due to mosquito bites medicine, it is characterized in that described medicament is solution, membrane, gel or ointment.
7. a kind of treatment dermatitis and eczema according to claim 6, pruritus due to mosquito bites medicine is characterized in that described medicament is an ointment.
8. one of claim 1-5 a kind of treats dermatitis and eczema, mosquito bite causes the application of pruritus medicine in preparation treatment dermatitis and eczema, pruritus due to mosquito bites medicine.
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| CN102219772A (en) * | 2011-06-20 | 2011-10-19 | 东莞广州中医药大学中医药数理工程研究院 | Cortex pseudolaricis acid complex with bioactivity and preparation method thereof |
| CN102973560A (en) * | 2012-12-03 | 2013-03-20 | 施惠娟 | Novel method of applying matrine to treating eczematous dermatitis |
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