CN116270786A - Ointment for relaxing muscles and tendons and dredging collaterals and preparation method thereof - Google Patents

Ointment for relaxing muscles and tendons and dredging collaterals and preparation method thereof Download PDF

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CN116270786A
CN116270786A CN202310361580.6A CN202310361580A CN116270786A CN 116270786 A CN116270786 A CN 116270786A CN 202310361580 A CN202310361580 A CN 202310361580A CN 116270786 A CN116270786 A CN 116270786A
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parts
ointment
tendons
extracting
relaxing
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黄继强
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Jiangsu Health Vocational College
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Jiangsu Health Vocational College
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11Pteridophyta or Filicophyta (ferns)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/237Notopterygium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286Carthamus (distaff thistle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/324Boswellia, e.g. frankincense
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention relates to an ointment for relaxing muscles and tendons and dredging collaterals and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The ointment for relaxing muscles and tendons and dredging collaterals is prepared by crushing, extracting, purifying and concentrating the following raw materials in parts by weight: 10-20 parts of common clubmoss herb, 7-17 parts of frankincense, 7-17 parts of notopterygium root, 7-17 parts of radix angelicae pubescentis, 7-17 parts of szechuan lovage rhizome, 7-17 parts of Chinese angelica, 1-11 parts of safflower, 95-105 parts of stearic acid, 35-45 parts of glyceryl monostearate, 95-105 parts of vaseline, 45-55 parts of lanolin, 2-10 parts of tween-80 and 45-55 parts of salicylic acid. Has the effects of relaxing muscles and tendons, expelling collateral obstruction, expelling cold, removing dampness, promoting blood circulation, and relieving pain, and is suitable for neck, shoulder, waist and leg pain or pain after acute injury caused by various fasciitis.

Description

Ointment for relaxing muscles and tendons and dredging collaterals and preparation method thereof
Technical Field
The invention relates to an ointment for relaxing muscles and tendons and dredging collaterals and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines.
Background
Fasciitis is a special response of our muscles and fascia to the appearance of aseptic inflammation. Wind-cold invasion, overfatigue, trauma, improper sleeping position and the like all cause acute onset of fasciitis. In addition, chronic injury, strain and the like of muscles and ligaments can cause fasciitis, and the phenomena of or intermittent chronic muscle pain, soreness, weakness and the like can occur. The traditional Chinese medicine considers that fasciitis is externally caused by wind-cold-dampness evil, traumatic strain and the like, and causes fasciitis damage, blood stasis stagnation, muscle spasm, meridian blockage and unsmooth qi and blood circulation; the internal and external symptoms are caused by kidney-qi deficiency and liver-qi deficiency. For the treatment of fasciitis, the traditional Chinese medicine has clouds: the disease of human being is usually prevalent in the viscera of the meridians from inside to outside, and the drug administration can be driven. If the disease is present, it can be obtained by sticking it to skin and tendons, and blocking the qi, so that the drug property is forced to pass through the pores and the striae of the skin, or extracted, or dispersed, especially if it is taken. Therefore, the fascial paste is a good treatment method for treating fascial inflammation.
The traditional Chinese medicine is derived from nature, has thousands of years of clinical application experience, is pure and mild, has small toxic and side effects, and is safer and more reliable than chemical synthetic products. If the traditional Chinese medicines are decocted into soup for oral administration, the traditional Chinese medicines are troublesome and the curative effect cannot be ensured, if the traditional Chinese medicines are singly or matched with the traditional Chinese medicines are ground into powder or decocted and concentrated to prepare a preparation with simpler process, the traditional Chinese medicines often have irritation to skin and cannot achieve good absorption effect. The preparation of the traditional Chinese medicine into the ointment form combines the essence of the traditional Chinese medicine with the modern biotechnology, so that the traditional Chinese medicine has better absorbability and achieves more remarkable permeation effect.
At present, most of the existing fasciitis treatment modes are grease ointments, but the existing fasciitis treatment modes have the defects of large peculiar smell, large dosage, stronger irritation, easy allergy, quick pain relieving, long curative effect and difficult absorption, and the ointment for treating the fasciitis has poor effect.
The invention adopts proper matrix as excipient to bear the weight of the traditional Chinese medicine, and the traditional Chinese medicine is smeared on the skin surface, can be permanently adhered to the skin surface and can keep the skin comfortable and breathable, and the traditional Chinese medicine can be well released from the matrix to enter the skin so as to exert the required drug effect, and the ointment can meet the requirements, and is guided by the theory of traditional Chinese medicine and has the characteristics of the ointment.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides an ointment for relaxing muscles and tendons and dredging collaterals and a preparation method thereof, which have the effects of relaxing muscles and tendons and dredging collaterals, dispelling cold and removing dampness, promoting blood circulation and relieving pain and the like, and are suitable for neck, shoulder, waist and leg pain or pain after acute injury caused by various fasciitis.
In order to solve the technical problems, the invention provides an ointment for relaxing muscles and tendons and dredging collaterals, which is prepared by crushing, extracting, purifying and concentrating the following raw materials in parts by weight: 10-20 parts of common clubmoss herb, 7-17 parts of frankincense, 7-17 parts of notopterygium root, 7-17 parts of radix angelicae pubescentis, 7-17 parts of szechuan lovage rhizome, 7-17 parts of Chinese angelica, 1-11 parts of safflower, 95-105 parts of stearic acid, 35-45 parts of glyceryl monostearate, 95-105 parts of vaseline, 45-55 parts of lanolin, 2-10 parts of tween-80 and 45-55 parts of salicylic acid.
The preparation method of the ointment for relaxing muscles and tendons and dredging collaterals comprises the following specific preparation steps:
(1) Crushing: respectively taking raw materials of lycopodium clavatum, ligusticum wallichii, angelica sinensis, safflower, frankincense, notopterygium root and radix angelicae pubescentis, removing impurities and rotten and deteriorated parts, cleaning, sun-drying, and respectively grinding into powder with the granularity of 2-5 mm;
(2) Extracting: weighing the common clubmoss herb, the szechuan lovage rhizome and the Chinese angelica which are treated in the step (1) according to the weight parts of the formula, respectively adding 10 times of 60% ethanol into the common clubmoss herb, the szechuan lovage rhizome and the Chinese angelica for 2 times of ethanol extraction, wherein each time of ethanol extraction is 1 hour, and uniformly mixing and stirring all the extracting solutions to obtain an ethanol extracting solution; weighing the frankincense, the notopterygium root and the pubescent angelica root which are treated in the step (1) according to the weight parts of the formula, adding purified water into the mixture, soaking the mixture for 24 hours at normal temperature, heating the mixture to boiling, keeping a micro-boiling state for 5 hours, extracting volatile oil, storing the volatile oil for later use, collecting a first water decoction, adding 8 times of purified water, extracting the volatile oil and a second water decoction for later use;
(3) Purifying: concentrating the second water decoction in the step (2) by a vacuum concentration method to 1.05-1.1g/ml to obtain a concentrated solution, and performing alcohol precipitation on the concentrated solution to obtain an alcohol precipitation solution with the alcohol content reaching 70%;
(4) Concentrating: uniformly mixing the alcohol extract in the step (2) and the alcohol precipitation in the step (3), and concentrating at 60 ℃ until the relative density is 1.2-1.25 to obtain dry extract;
(5) And (3) forming: mixing stearic acid, glyceryl monostearate, vaseline, lanoline and liquid paraffin according to formula weight parts uniformly, forming oil phase in water bath at 80deg.C, mixing Tween-80 and distilled water according to formula weight parts, and forming water phase in water bath at 80deg.C;
(6) Pouring the water phase in the step (5) into the oil phase, stirring, adding 45-55 parts of salicylic acid, uniformly mixing, pouring into the dry extract in the step (4), stirring until the texture is uniform, and naturally cooling after no impurity and no block are generated, thus obtaining the tendon relaxing and vein relaxing ointment.
And (3) stirring in the step (6) along the same direction at a speed of 40-60 r/min.
The weight parts and the preparation process parameters of the raw material medicines of each component of the ointment for relaxing muscles and tendons can be specifically determined according to actual needs, and good curative effects can be ensured. The proportion of each raw material medicine is adjusted according to the illness state, the time of illness and the like of the patient so as to achieve the best effect and meet the requirement of complete cure.
The raw material medicines adopted by the invention have medicinal effects aiming at fasciitis.
Herb of common clubmoss: warm nature, slightly sweet taste, no toxicity, relaxing tendons, activating collaterals, diminishing inflammation and removing dampness.
Mastic gum: pungent and bitter in nature, warm in nature, promoting blood circulation, promoting qi circulation, relieving pain, relieving swelling and promoting tissue regeneration.
Notopterygium root: pungent and bitter taste, warm nature, antipyretic, analgesic, antibacterial and anti-inflammatory.
Radix angelicae pubescentis): sweet in taste, slightly warm in nature, nontoxic, and capable of dispelling wind and eliminating dampness, dispelling cold and relieving pain.
Ligusticum wallichii: pungent in flavor, warm in nature, dispel wind and dry dampness, activate blood and relieve pain.
Chinese angelica root: sweet in taste, warm in nature, blood-replenishing and blood-activating.
Safflower: pungent and warm, nontoxic, and clear meridians and promote blood circulation.
The invention is prepared by adopting the pure natural plant medicinal materials through scientific compatibility, has obvious curative effect on pains caused by various fasciitis, and can achieve the aim of radically treating the diseases after the patients apply the ointment to the affected parts to perform proper massage and take the medicines for a certain time. Has the advantages of relaxing muscles and tendons, expelling cold, removing dampness, promoting blood circulation, relieving pain, and being natural and can be used for treating neck, shoulder, waist and leg pain or pain after acute injury caused by various fasciitis
Description of the embodiments
The following detailed description of specific embodiments of the invention is provided in further detail. The technology or products not identified in the examples are conventional in the art or available commercially.
Example 1: the ointment for relaxing muscles and tendons and dredging collaterals is prepared by crushing, extracting, purifying and concentrating the following raw materials in parts by weight: 15 parts of lycopodium clavatum, 12 parts of frankincense, 12 parts of notopterygium root, 12 parts of radix angelicae pubescentis, 12 parts of ligusticum wallichii, 12 parts of angelica sinensis, 6 parts of safflower, 100 parts of stearic acid, 40 parts of glyceryl monostearate, 100 parts of Vaseline, 50 parts of lanolin, 5 parts of tween-80 and 50 parts of salicylic acid.
The preparation method of the ointment for relaxing muscles and tendons and dredging collaterals comprises the following specific preparation steps:
(1) Crushing: respectively taking raw materials of lycopodium clavatum, ligusticum wallichii, angelica sinensis, safflower, frankincense, notopterygium root and radix angelicae pubescentis, removing impurities and rotten and deteriorated parts, cleaning, sun-drying, and respectively grinding into powder with the granularity of 3 mm;
(2) Extracting: weighing the common clubmoss herb, the szechuan lovage rhizome and the Chinese angelica which are treated in the step (1) according to the weight parts of the formula, respectively adding 10 times of 60% ethanol into the common clubmoss herb, the szechuan lovage rhizome and the Chinese angelica for 2 times of ethanol extraction, wherein each time of ethanol extraction is 1 hour, and uniformly mixing and stirring all the extracting solutions to obtain an ethanol extracting solution; weighing the frankincense, the notopterygium root and the pubescent angelica root which are treated in the step (1) according to the weight parts of the formula, adding purified water into the mixture, soaking the mixture for 24 hours at normal temperature, heating the mixture to boiling, keeping a micro-boiling state for 5 hours, extracting volatile oil, storing the volatile oil for later use, collecting a first water decoction, adding 8 times of purified water, extracting the volatile oil and a second water decoction for later use;
(3) Purifying: concentrating the second water decoction in the step (2) by a vacuum concentration method to 1g/ml to obtain a concentrated solution, and carrying out alcohol precipitation on the concentrated solution to ensure that the alcohol content reaches 70% to obtain an alcohol precipitation solution;
(4) Concentrating: uniformly mixing the alcohol extract in the step (2) and the alcohol precipitation in the step (3), and concentrating at 60 ℃ until the relative density is 1.22 to obtain dry extract;
(5) And (3) forming: mixing stearic acid, glyceryl monostearate, vaseline, lanoline and liquid paraffin according to formula weight parts uniformly, forming oil phase in water bath at 80deg.C, mixing Tween-80 and distilled water according to formula weight parts, and forming water phase in water bath at 80deg.C;
(6) Pouring the water phase in the step (5) into the oil phase, stirring, adding 50 parts of salicylic acid, uniformly mixing, pouring into the dry extract in the step (4), stirring until the texture is uniform, no impurity or block exists, and naturally cooling to obtain the tendon relaxing and vein relaxing ointment. Stirring at 50r/min in the same direction.
The ointment is applied to the affected part for 3 times a day in the morning, in the middle and at night by taking 7 days as a treatment course, and is properly massaged, the symptoms are obviously relieved after 1 treatment course, and the patients are completely cured after 2 treatment courses, so that the treatment effect is good.
Example 2: the ointment for relaxing muscles and tendons and dredging collaterals is prepared by crushing, extracting, purifying and concentrating the following raw materials in parts by weight: 20 parts of lycopodium clavatum, 17 parts of frankincense, 17 parts of notopterygium root, 17 parts of radix angelicae pubescentis, 17 parts of ligusticum wallichii, 17 parts of angelica sinensis, 11 parts of safflower, 105 parts of stearic acid, 45 parts of glyceryl monostearate, 105 parts of vaseline, 55 parts of lanolin, 10 parts of tween-80 and 55 parts of salicylic acid.
The preparation method of the ointment for relaxing muscles and tendons and dredging collaterals comprises the following specific preparation steps:
(1) Crushing: respectively taking raw materials of lycopodium clavatum, ligusticum wallichii, angelica sinensis, safflower, frankincense, notopterygium root and radix angelicae pubescentis, removing impurities and rotten and deteriorated parts, cleaning, sun-drying, and respectively grinding into powder with the granularity of 5 mm;
(2) Extracting: weighing the common clubmoss herb, the szechuan lovage rhizome and the Chinese angelica which are treated in the step (1) according to the weight parts of the formula, respectively adding 60% ethanol into the common clubmoss herb, the szechuan lovage rhizome and the Chinese angelica for 2 times of ethanol extraction, wherein each time of ethanol extraction is 1 hour, and uniformly mixing and stirring all the extracting solutions to obtain an ethanol extracting solution; weighing the frankincense, the notopterygium root and the pubescent angelica root which are treated in the step (1) according to the weight parts of the formula, adding purified water into the mixture, soaking the mixture for 24 hours at normal temperature, heating the mixture to boil, keeping a micro-boiling state for 5 hours, extracting volatile oil, storing the volatile oil for standby, collecting a first water decoction, adding 8 times of purified water into the first water decoction, extracting the volatile oil and a second water decoction for standby;
(3) Purifying: concentrating the second water decoction in the step (2) by a vacuum concentration method to 1.1g/ml to obtain a concentrated solution, and performing alcohol precipitation on the concentrated solution to obtain an alcohol precipitation solution with 70% of alcohol content;
(4) Concentrating: uniformly mixing the alcohol extract in the step (2) and the alcohol precipitation in the step (3), and concentrating at 60 ℃ until the relative density is 1.25 to obtain dry extract;
(5) And (3) forming: mixing stearic acid, glyceryl monostearate, vaseline, lanoline and liquid paraffin according to formula weight parts uniformly, forming oil phase in water bath at 80deg.C, mixing Tween-80 and distilled water according to formula weight parts, and forming water phase in water bath at 80deg.C;
(6) Pouring the water phase in the step (5) into the oil phase, stirring, adding 55 parts of salicylic acid, uniformly mixing, pouring into the dry extract in the step (4), stirring until the texture is uniform, and naturally cooling after no impurity and no block are generated, thus obtaining the tendon relaxing and vein relaxing ointment. Stirring was carried out at a speed of 60r/min in the same direction during stirring.
The ointment is applied to the affected part for 3 times a day, namely, early, middle and late, by taking 7 days as a treatment course, the symptoms are obviously relieved after 1 treatment course, 2 treatment courses are basically cured, and the treatment effect is good after being consolidated for 2 treatment courses.
Example 3: the ointment for relaxing muscles and tendons and dredging collaterals is prepared by crushing, extracting, purifying and concentrating the following raw materials in parts by weight: 10 parts of lycopodium clavatum, 7 parts of frankincense, 7 parts of notopterygium root, 7 parts of radix angelicae pubescentis, 7 parts of ligusticum wallichii, 7 parts of angelica sinensis, 1 part of safflower, 95 parts of stearic acid, 35 parts of glyceryl monostearate, 95 parts of Vaseline, 45 parts of lanolin, 2 parts of tween-80 and 45 parts of salicylic acid.
The preparation method of the ointment for relaxing muscles and tendons and dredging collaterals comprises the following specific preparation steps:
(1) Crushing: respectively taking raw materials of lycopodium clavatum, ligusticum wallichii, angelica sinensis, safflower, frankincense, notopterygium root and radix angelicae pubescentis, removing impurities and rotten and deteriorated parts, cleaning, sun-drying, and respectively grinding into powder with the granularity of 2 mm;
(2) Extracting: weighing the common clubmoss herb, the szechuan lovage rhizome and the Chinese angelica which are treated in the step (1) according to the weight parts of the formula, respectively adding 10 times of 60% ethanol into the common clubmoss herb, the szechuan lovage rhizome and the Chinese angelica for 2 times of ethanol extraction, wherein each time of ethanol extraction is 1 hour, and uniformly mixing and stirring all the extracting solutions to obtain an ethanol extracting solution; respectively weighing the frankincense, the notopterygium root and the pubescent angelica root which are treated in the step (1) according to the weight parts of the formula, adding purified water into the mixture, soaking the mixture for 24 hours at normal temperature, heating the mixture to boil, keeping a micro-boiling state for 5 hours, extracting volatile oil, storing the volatile oil for standby, collecting the first water decoction, adding 8 times of purified water into the treated frankincense, the notopterygium root and the pubescent angelica root, extracting the volatile oil and the second water decoction for standby;
(3) Purifying: concentrating the second water decoction in the step (2) by a vacuum concentration method to 1.05g/ml to obtain a concentrated solution, and performing alcohol precipitation on the concentrated solution to obtain an alcohol precipitation solution with the alcohol content reaching 70%;
(4) Concentrating: uniformly mixing the alcohol extract in the step (2) and the alcohol precipitation in the step (3), and concentrating at 60 ℃ until the relative density is 1.2 to obtain dry extract;
(5) And (3) forming: mixing stearic acid, glyceryl monostearate, vaseline, lanoline and liquid paraffin according to formula weight parts uniformly, forming oil phase in water bath at 80deg.C, mixing Tween-80 and distilled water according to formula weight parts, and forming water phase in water bath at 80deg.C;
(6) Pouring the water phase in the step (5) into the oil phase, stirring, adding 45 parts of salicylic acid, uniformly mixing, pouring into the dry extract in the step (4), stirring until the texture is uniform, and naturally cooling after no impurity and no block are generated, thus obtaining the tendon relaxing and vein relaxing ointment. Stirring at 40r/min in the same direction.
The ointment is applied to the affected part for 3 times a day, namely, early, middle and late, by taking 7 days as a treatment course, the symptoms are obviously relieved after 1 treatment course, 2 treatment courses are basically cured, and the curing is completed after 2 treatment courses are continuously consolidated, so that the treatment effect is good.
While the present invention has been described with reference to the embodiments, the scope of the invention is not limited to the above-described embodiments, and various changes and modifications can be made within the spirit and principles of the invention without departing from the spirit and scope of the invention as defined by the appended claims.

Claims (4)

1. An ointment for relaxing muscles and tendons and dredging collaterals, which is characterized in that: the ointment is prepared by crushing, extracting, purifying and concentrating the following raw materials in parts by weight: 10-20 parts of common clubmoss herb, 7-17 parts of frankincense, 7-17 parts of notopterygium root, 7-17 parts of radix angelicae pubescentis, 7-17 parts of szechuan lovage rhizome, 7-17 parts of Chinese angelica, 1-11 parts of safflower, 95-105 parts of stearic acid, 35-45 parts of glyceryl monostearate, 95-105 parts of vaseline, 45-55 parts of lanolin, 2-10 parts of tween-80 and 45-55 parts of salicylic acid.
2. A method for preparing the tendon-relaxing and vein-relaxing ointment according to claim 1, which is characterized in that: the preparation method comprises the following specific steps:
(1) Crushing: respectively taking raw materials of lycopodium clavatum, ligusticum wallichii, angelica sinensis, safflower, frankincense, notopterygium root and radix angelicae pubescentis, removing impurities and rotten and deteriorated parts, cleaning, sun-drying, and respectively grinding into powder with the granularity of 2-5 mm;
(2) Extracting: weighing the common clubmoss herb, the szechuan lovage rhizome and the Chinese angelica which are treated in the step (1) according to the weight parts of the formula, respectively adding 10 times of 60% ethanol into the common clubmoss herb, the szechuan lovage rhizome and the Chinese angelica for 2 times of ethanol extraction, wherein each time of ethanol extraction is 1 hour, and uniformly mixing and stirring all the extracting solutions to obtain an ethanol extracting solution; weighing the frankincense, the notopterygium root and the pubescent angelica root which are treated in the step (1) according to the weight parts of the formula, adding purified water into the mixture, soaking the mixture for 24 hours at normal temperature, heating the mixture to boiling, keeping a micro-boiling state for 5 hours, extracting volatile oil, storing the volatile oil for later use, collecting a first water decoction, adding 8 times of purified water, extracting the volatile oil and a second water decoction for later use;
(3) Purifying: concentrating the second water decoction in the step (2) to 1.05-1.1g/ml to obtain concentrated solution, and precipitating with ethanol to 70% ethanol content to obtain ethanol precipitation solution;
(4) Concentrating: uniformly mixing the alcohol extract in the step (2) and the alcohol precipitation in the step (3), and concentrating at 60 ℃ until the relative density is 1.2-1.25 to obtain dry extract;
(5) And (3) forming: mixing stearic acid, glyceryl monostearate, vaseline, lanoline and liquid paraffin according to formula weight parts uniformly, forming oil phase in water bath at 80deg.C, mixing Tween-80 and distilled water according to formula weight parts, and forming water phase in water bath at 80deg.C;
(6) Pouring the water phase in the step (5) into the oil phase, stirring, adding 45-55 parts of salicylic acid, uniformly mixing, pouring into the dry extract in the step (4), stirring until the texture is uniform, and naturally cooling after no impurity and no block are generated, thus obtaining the tendon relaxing and vein relaxing ointment.
3. The method for preparing the ointment for relaxing muscles and tendons and dredging collaterals according to claim 2, wherein the method comprises the following steps: and (3) concentrating in vacuum.
4. The method for preparing the ointment for relaxing muscles and tendons and dredging collaterals according to claim 2, wherein the method comprises the following steps: and (3) stirring in the step (6) along the same direction at a speed of 40-60 r/min.
CN202310361580.6A 2023-04-07 2023-04-07 Ointment for relaxing muscles and tendons and dredging collaterals and preparation method thereof Pending CN116270786A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106309533A (en) * 2016-10-12 2017-01-11 上海市浦东新区光明中医医院 Traditional chinese medicine composition and application thereof
CN107233396A (en) * 2017-08-01 2017-10-10 梁晶 A kind of Chinese medicinal ointment for treating protrusion of lumber intervertebral disc, plaster and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106309533A (en) * 2016-10-12 2017-01-11 上海市浦东新区光明中医医院 Traditional chinese medicine composition and application thereof
CN107233396A (en) * 2017-08-01 2017-10-10 梁晶 A kind of Chinese medicinal ointment for treating protrusion of lumber intervertebral disc, plaster and preparation method thereof

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