CN1430996A - Oral prepn. of big bupleurum root and its prodn. methods - Google Patents
Oral prepn. of big bupleurum root and its prodn. methods Download PDFInfo
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- CN1430996A CN1430996A CN 03112711 CN03112711A CN1430996A CN 1430996 A CN1430996 A CN 1430996A CN 03112711 CN03112711 CN 03112711 CN 03112711 A CN03112711 A CN 03112711A CN 1430996 A CN1430996 A CN 1430996A
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Abstract
An oral-applied Chinese medicine in the form of liquid for treating acute and chronic cholecystitis is prepared from 8 Chinese-medicinal materials including bupleurum root, scutellaria root, white peony root, ginger, etc through extracting liquid and purifying.
Description
Technical field:
The present invention relates to a kind of Chinese patent medicine.
Background technology:
Cholecystitis is because biliary system is subjected to the invasion and attack of antibacterial, calculus, chemokines etc., causes the gallbladder disease of pathological change, and according to the preliminary statistics, there is patient more than 2,000 ten thousand in the whole nation.Though the Chinese and western drugs of some treatment cholecystitis is arranged on the market,, has certain defective at aspects such as using method, therapeutic effect owing to reasons such as its prescription, dosage forms.
Summary of the invention:
The object of the present invention is to provide a kind of taking convenience, effective big Radix Bupleuri oral formulations and the production method thereof of treatment cholecystitis.
Technical solution of the present invention is:
A kind of big Radix Bupleuri oral formulations, its feature: make by containing following materials of weight proportions:
Radix Bupleuri 15～22% Radix Scutellariaes 8～14%
The Radix Paeoniae Alba 8～14% Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s 8～14%
Fructus Aurantii Immaturus (parched) 8～14% Radix Et Rhizoma Rhei 6～10%
Rhizoma Zingiberis Recens 5～20% Fructus Jujubaes 10～16%.
Oral formulations is granule or tablet, capsule, oral liquid.
A kind of production method of big Radix Bupleuri oral formulations is characterized in that: comprise the following steps:
1. with the Radix Et Rhizoma Rhei of 6～10% weight portions, use ethanol extraction, collect extracting solution;
2. with 15～22% Radix Bupleuri, 8～14% Radix Scutellariae, 8～14% the Radix Paeoniae Alba, 8～14% Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), 8～14% Fructus Aurantii Immaturus (parched), 15～20% Rhizoma Zingiberis Recens, 10～16% Fructus Jujubae seven flavor Chinese medicines, obtain extracting solution with decoction and alcohol sedimentation technique;
3. with step 1., the extracting solution that 2. obtains merges, and reclaims ethanol, obtains medicinal liquid;
4. will produce oral formulations through the 3. medicinal liquid of gained.
The method that 4. step produces oral granular formulation is: medicinal liquid is concentrated into clear paste, and the qinghuo reagent spray drying gets the medicine dried cream powder, again dried cream powder is made granule, promptly gets oral granular formulation.
The method that 4. step produces oral tablet or capsule is: medicinal liquid by resin absorption or membrance separation, flocculation sediment, is collected refined solution, and with the refined solution concentrate drying extract that must loosen, the extract that will loosen is again made tablet or capsule.
The method that 4. step produces oral liquid is: medicinal liquid by resin absorption or membrance separation, flocculation sediment, is collected refined solution, with refined solution concentrate clear paste, again this clear paste is mixed with oral liquid.
The present invention can effectively treat acute and chronic cholecystitis, Chinese medicine preparation sheerly, it is a kind of new oral Chinese medicine preparation that develops according to tcm theory and modern Chinese medicine preparation technique, clinical trial shows that the gallbladder pain that hot plate, acetic acid are caused has tangible antagonism, it is swollen to suppress rat granuloma, bile flow after the obvious increase administration, total bilirubin, cholesterol, bile acid content in the slight reduction bile, escherichia coli growths there is protective effect, the mice of coli-infection is had protective effect; Toxicological test shows that said preparation safety has no side effect in addition; Adopt the dosage form of modern Chinese medicine, taking convenience; Manufacture method is simple, cost is low.
The specific embodiment:
The invention will be further described below in conjunction with embodiment.
Embodiment 1:
1. with the Radix Et Rhizoma Rhei of 6% weight portion,, collect extracting solution with 30～90% (example 30%, 50%, 70%, 90%) ethanol extraction of 5～15 times of amounts (V/W) (5,10,15 times of examples);
2. with 21% Radix Bupleuri, 8% Radix Scutellariae, 10% the Radix Paeoniae Alba, 12% Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), 14% Fructus Aurantii Immaturus (parched), 19% Rhizoma Zingiberis Recens, 10% Fructus Jujubae seven flavor Chinese medicines, water with 5～15 times of amounts (V/W) (5,10,15 times of examples), heating decocts, get decocting liquid, decocting liquid is filtered, filtrate concentrates, adding ethanol makes content reach 30～80% (examples 30%, 50%, 70%, 80%), standing over night filters, and gets filtrate;
3. with step 1., the extracting solution that 2. obtains, filtrate merge, conventional method reclaims ethanol, medicinal liquid;
4. above-mentioned medicinal liquid is concentrated into clear paste, qinghuo reagent is spray drying according to a conventional method, gets the medicine dried cream powder, again dried cream powder is made granule according to a conventional method, promptly gets oral granular formulation.
Embodiment 2:
1. with the Radix Et Rhizoma Rhei of 8% weight portion,, collect extracting solution with 30～90% (example 30%, 50%, 70%, 90%) ethanol extraction of 5～15 times of amounts (V/W) (5,10,15 times of examples);
2. with 18% Radix Bupleuri, 12% Radix Scutellariae, 14% the Radix Paeoniae Alba, 10% Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), 8% Fructus Aurantii Immaturus (parched), 15% Rhizoma Zingiberis Recens, 15% Fructus Jujubae seven flavor Chinese medicines, water with 5～15 times of amounts (V/W) (5,10,15 times of examples), heating decocts, get decocting liquid, decocting liquid is filtered, filtrate concentrates, adding ethanol makes content reach 30～80% (examples 30%, 50%, 70%, 80%), standing over night filters, and gets filtrate;
3. with step 1., the extracting solution that 2. obtains, filtrate merge, conventional method reclaims ethanol, medicinal liquid;
4. with above-mentioned medicinal liquid with conventional resin adsorption method (or conventional membrane separation process, flocculent precipitation) purification, and collect refined solution, concentrate according to a conventional method again, the dry extract that must loosen, make tablet more according to a conventional method.
Embodiment 3:
1. with the Radix Et Rhizoma Rhei of 10% weight portion,, collect extracting solution with 30～90% (example 30%, 50%, 70%, 90%) ethanol extraction of 5～15 times of amounts (V/W) (5,10,15 times of examples);
2. with 16% Radix Bupleuri, 10% Radix Scutellariae, 8% the Radix Paeoniae Alba, 14% Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), 12% Fructus Aurantii Immaturus (parched), 17% Rhizoma Zingiberis Recens, 13% Fructus Jujubae seven flavor Chinese medicines, water with 5～15 times of amounts (V/W) (5,10,15 times of examples), heating decocts, get decocting liquid, decocting liquid is filtered, filtrate concentrates, adding ethanol makes content reach 30～80% (examples 30%, 50%, 70%, 80%), standing over night filters, and gets filtrate;
3. with step 1., the extracting solution that 2. obtains, filtrate merge, conventional method reclaims ethanol, medicinal liquid;
4. with above-mentioned medicinal liquid with conventional resin adsorption method (or conventional membrane separation process, flocculent precipitation) purification, and collect refined solution, concentrate according to a conventional method again, the dry extract that must loosen, the extract that will loosen is again made capsule according to a conventional method.
Embodiment 4:
1. with the Radix Et Rhizoma Rhei of 9% weight portion,, collect extracting solution with 30～90% (example 30%, 50%, 70%, 90%) ethanol extraction of 5～15 times of amounts (V/W) (5,10,15 times of examples);
2. with 19% Radix Bupleuri, 14% Radix Scutellariae, 12% the Radix Paeoniae Alba, 8% Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), 10% Fructus Aurantii Immaturus (parched), 16% Rhizoma Zingiberis Recens, 12% Fructus Jujubae seven flavor Chinese medicines, water with 5～15 times of amounts (V/W) (5,10,15 times of examples), heating decocts, get decocting liquid, decocting liquid is filtered, filtrate concentrates, adding ethanol makes content reach 30～80% (examples 30%, 50%, 70%, 80%), standing over night filters, and gets filtrate;
3. with step 1., the extracting solution that 2. obtains, filtrate merge, conventional method reclaims ethanol, medicinal liquid;
4. with above-mentioned medicinal liquid with conventional resin adsorption method (or conventional membrane separation process, flocculent precipitation) purification, and collect refined solution, concentrate according to a conventional method again clear paste, again this clear paste is mixed with oral liquid according to a conventional method.
Claims (9)
1, a kind of big Radix Bupleuri oral formulations is characterized in that: make by containing following materials of weight proportions:
Radix Bupleuri 15～22% Radix Scutellariaes 8～14%
The Radix Paeoniae Alba 8～14% Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s 8～14%
Fructus Aurantii Immaturus (parched) 8～14% Radix Et Rhizoma Rhei 6～10%
Rhizoma Zingiberis Recens 5～20% Fructus Jujubaes 10～16%.
2, big Radix Bupleuri oral formulations according to claim 1 is characterized in that; Oral formulations is granule or tablet, capsule.
3, big Radix Bupleuri oral formulations according to claim 1, it is characterized in that: oral formulations is an oral liquid.
4, a kind of production method of big Radix Bupleuri oral formulations is characterized in that: comprise the following steps:
1. with the Radix Et Rhizoma Rhei of 6～10% weight portions, use ethanol extraction, collect extracting solution;
2. with 15～22% Radix Bupleuri, 8～14% Radix Scutellariae, 8～14% the Radix Paeoniae Alba, 8～14% Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), 8～14% Fructus Aurantii Immaturus (parched), 15～20% Rhizoma Zingiberis Recens, 10～16% Fructus Jujubae seven flavor Chinese medicines, obtain extracting solution with decoction and alcohol sedimentation technique;
3. with step 1., the extracting solution that 2. obtains merges, and reclaims ethanol, obtains medicinal liquid;
4. will produce oral formulations through the 3. medicinal liquid of gained.
5, the production method of big Radix Bupleuri oral formulations according to claim 4, it is characterized in that: the method that 4. step produces oral granular formulation is: medicinal liquid is concentrated into clear paste, and the qinghuo reagent spray drying gets the medicine dried cream powder, again dried cream powder is made granule, promptly get oral granular formulation.
6, the production method of big Radix Bupleuri oral formulations according to claim 4, it is characterized in that: the method that 4. step produces oral tablet or capsule is: with medicinal liquid be further purified, concentrate drying gets dry extract, dry extract made tablet or capsule again.
7, the production method of big Radix Bupleuri oral formulations according to claim 6 is characterized in that: the method for purification is: medicinal liquid by resin absorption or membrance separation, flocculation sediment, is collected refined solution.
8, the production method of big Radix Bupleuri oral formulations according to claim 4 is characterized in that: the method that 4. step produces oral liquid is: with medicinal liquid be further purified, concentrate clear paste, again this clear paste is mixed with oral liquid.
9, the production method of big Radix Bupleuri oral formulations according to claim 8 is characterized in that: the method for purification is: medicinal liquid by resin absorption or membrance separation, flocculation sediment, is collected refined solution.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 03112711 CN1430996A (en) | 2003-01-15 | 2003-01-15 | Oral prepn. of big bupleurum root and its prodn. methods |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 03112711 CN1430996A (en) | 2003-01-15 | 2003-01-15 | Oral prepn. of big bupleurum root and its prodn. methods |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100425226C (en) * | 2004-02-10 | 2008-10-15 | 湖北丽益医药科技有限公司 | Chinese medicine composition for treating acute cholecystitis and preparing method thereof |
| CN101428049B (en) * | 2008-12-11 | 2011-08-31 | 江苏省中国科学院植物研究所 | Upper respiratory tract infection resistant medicament composition, preparation and uses thereof |
| CN102579730A (en) * | 2012-03-22 | 2012-07-18 | 吉林紫鑫药业股份有限公司 | Medicine composition for treating acute or chronic cholecystitis and acute or chronic pancreatitis |
| CN104815306A (en) * | 2015-05-09 | 2015-08-05 | 高淑贤 | Medicine for treating acute cholecystitis and preparation method thereof |
| CN105250963A (en) * | 2015-11-04 | 2016-01-20 | 安徽益健堂中药饮片科技有限公司 | Traditional Chinese medicine composition for treating cholecystitis and gall-stone |
| CN105267911A (en) * | 2015-01-16 | 2016-01-27 | 王新建 | Traditional Chinese medicine for treating chronic cholecystitis |
-
2003
- 2003-01-15 CN CN 03112711 patent/CN1430996A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100425226C (en) * | 2004-02-10 | 2008-10-15 | 湖北丽益医药科技有限公司 | Chinese medicine composition for treating acute cholecystitis and preparing method thereof |
| CN101428049B (en) * | 2008-12-11 | 2011-08-31 | 江苏省中国科学院植物研究所 | Upper respiratory tract infection resistant medicament composition, preparation and uses thereof |
| CN102579730A (en) * | 2012-03-22 | 2012-07-18 | 吉林紫鑫药业股份有限公司 | Medicine composition for treating acute or chronic cholecystitis and acute or chronic pancreatitis |
| CN102579730B (en) * | 2012-03-22 | 2014-01-08 | 吉林紫鑫药业股份有限公司 | Medicine composition for treating acute or chronic cholecystitis and acute or chronic pancreatitis |
| CN105267911A (en) * | 2015-01-16 | 2016-01-27 | 王新建 | Traditional Chinese medicine for treating chronic cholecystitis |
| CN104815306A (en) * | 2015-05-09 | 2015-08-05 | 高淑贤 | Medicine for treating acute cholecystitis and preparation method thereof |
| CN105250963A (en) * | 2015-11-04 | 2016-01-20 | 安徽益健堂中药饮片科技有限公司 | Traditional Chinese medicine composition for treating cholecystitis and gall-stone |
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