CN105250963A - Traditional Chinese medicine composition for treating cholecystitis and gall-stone - Google Patents

Traditional Chinese medicine composition for treating cholecystitis and gall-stone Download PDF

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Publication number
CN105250963A
CN105250963A CN201510752548.6A CN201510752548A CN105250963A CN 105250963 A CN105250963 A CN 105250963A CN 201510752548 A CN201510752548 A CN 201510752548A CN 105250963 A CN105250963 A CN 105250963A
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radix
chinese medicine
cholecystitis
medicine composition
parts
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温同民
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Anhui Yijiantang Traditional Chinese Medicine Pieces Science And Technology Co Ltd
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Anhui Yijiantang Traditional Chinese Medicine Pieces Science And Technology Co Ltd
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Abstract

The invention discloses a traditional Chinese medicine composition for treating cholecystitis and gall-stone. The composition is prepared from the following medicinal raw materials in parts by weight: 18 parts of radix bupleuri, 9 parts of rheum officinale, 9 parts of radix paeoniae alba, 9 parts of fructus aurantii immaturus, 9 parts of radix scutellariae, 9 parts of pinellia ternate, 9 parts of radix curcumae and 9 parts of raw ginger. Compared with the prior art, the traditional Chinese medicine composition has the advantages of promoting qi circulation, eliminating stagnation, soothing liver-gallbladder, clearing heat and dredging stranguria, and has quick response and no toxic or side effect when being used for treating acute cholecystitis, gall-stone and chronic cholecystitis.

Description

A kind of Chinese medicine composition for the treatment of cholecystitis, cholelithiasis
Technical field
The present invention relates to the field of Chinese medicines, in particular a kind of Chinese medicine composition for the treatment of cholecystitis, cholelithiasis.
Background technology
Cholelithiasis, cholecystitis are current frequently-occurring disease, commonly encountered diseases, and the usually reciprocal causation on pathology of both cholelithiasis and cholecystitis.Cholelithiasis can bring out cholecystitis, and cholecystitis is one of reason promoting that cholelithiasis is formed, and two kinds of pathological changes are normal with occurring.The traditional Chinese medical science is thought, cholelithiasis, cholecystitis belong to the category such as " hypochondriac pain ", " gastric abscess ", " jaundice ", is because feelings will is smooth, and surfeit delicious food is greasy etc. causes depression of liver-QI, dysfunction of the spleen in transportation, damp and hot interior life, and heat decocts bile, condenses into stone; Stone resistance biliary tract, then raw all cards.The method of existing treatment cholelithiasis, cholecystitis mostly is modus operandi and oral western medicine, and perform the operation very big to the actual bodily harm of patient, oral western medicine effect is bad, also has side effect simultaneously.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, provide a kind of Chinese medicine composition for the treatment of cholecystitis, cholelithiasis, there is the merit of promoting QI to circulate and dispersing the agglomeration of the pathogens, 'Shugan Lidan ', clearing heat and freeing strangury, be used for the treatment of acute cholecystitis and cholelithiasis dampness-heat in the liver and gallbladder person, instant effect, without any side effects.
The present invention is achieved by the following technical solutions: a kind of Chinese medicine composition for the treatment of cholecystitis, cholelithiasis, it is characterized in that, be made up of following crude drug, the weight portion of each crude drug is: Radix Bupleuri 16-20, Radix Et Rhizoma Rhei 7-11, Radix Paeoniae Alba 7-11, Fructus Aurantii Immaturus 7-11, Radix Scutellariae 7-11, Rhizoma Pinelliae 7-11, Radix Curcumae 7-11, Rhizoma Zingiberis Recens 7-11.
As the further optimization of such scheme, a kind of Chinese medicine composition for the treatment of cholecystitis, cholelithiasis, is made up of following crude drug, and the weight portion of each crude drug is: Radix Bupleuri 16, Radix Et Rhizoma Rhei 7, the Radix Paeoniae Alba 7, Fructus Aurantii Immaturus 7, Radix Scutellariae 7, the Rhizoma Pinelliae 7, Radix Curcumae 7, Rhizoma Zingiberis Recens 7.
As the further optimization of such scheme, a kind of Chinese medicine composition for the treatment of cholecystitis, cholelithiasis, be made up of following crude drug, the weight portion of each crude drug is: Radix Bupleuri 20, Radix Et Rhizoma Rhei 11, the Radix Paeoniae Alba 11, Fructus Aurantii Immaturus 11, Radix Scutellariae 11, the Rhizoma Pinelliae 11, Radix Curcumae 11, Rhizoma Zingiberis Recens 11.
As the further optimization of such scheme, a kind of Chinese medicine composition for the treatment of cholecystitis, cholelithiasis, is made up of following crude drug, and the weight portion of each crude drug is: Radix Bupleuri 18, Radix Et Rhizoma Rhei 9, the Radix Paeoniae Alba 9, Fructus Aurantii Immaturus 9, Radix Scutellariae 9, the Rhizoma Pinelliae 9, Radix Curcumae 9, Rhizoma Zingiberis Recens 9.
As the further optimization of such scheme, a kind of Chinese medicine composition for the treatment of cholecystitis, cholelithiasis, described Chinese medicine composition is prepared to tablet, capsule or oral liquid.
As the further optimization of such scheme, the application of a kind of Chinese medicine composition in the medicine for the preparation for the treatment of treatment cholecystitis.
As the further optimization of such scheme, the application of a kind of Chinese medicine composition in the medicine for the preparation for the treatment of treatment cholelithiasis.
Compared with the prior art, of the present inventionly a kind ofly treat cholecystitis, the beneficial effect of Chinese medicine composition of cholelithiasis be embodied in:
1, a kind of Chinese medicine composition for the treatment of cholecystitis, cholelithiasis of the present invention, this Chinese medicine composition has clearing away heat-damp and promoting diuresis, 'Shugan Lidan ', treating stranguria by Shi Zhigong, has the effect of lithodialysis, treatment acute cholecystitis, cholelithiasis, chronic cholecystitis good effect, instant effect, without any side effects.
2, of the present inventionly a kind ofly treat cholecystitis, the dosage of Chinese medicine composition of cholelithiasis depends on concrete dosage form, the factors such as patient age, body weight, health status.General Requirements is for oral administration, and with soak by water, 1-2 agent on the one 7 days is a course for the treatment of.
3, of the present inventionly a kind ofly treat cholecystitis, the Chinese medicine composition of cholelithiasis obviously can reduce and cause gall-stone formation rate, Ca2+ concentration in obvious reduction bile, make unconjugated bilirubin calcium salt be formed like this to reduce, decrease the deposition of bilirubinate and lithogenous probability.
Detailed description of the invention
Elaborate to embodiments of the invention below, the present embodiment is implemented under premised on technical solution of the present invention, give detailed embodiment and concrete operating process, but protection scope of the present invention is not limited to following embodiment.If the component raw material related in embodiment is without specified otherwise, be the convenience goods can bought on the market.
Embodiment 1
A kind of Chinese medicine composition for the treatment of cholecystitis, cholelithiasis of the present invention, is made up of following crude drug: Radix Bupleuri 16g, Radix Et Rhizoma Rhei 7g, Radix Paeoniae Alba 7g, Fructus Aurantii Immaturus 7g, Radix Scutellariae 7g, Rhizoma Pinelliae 7g, Radix Curcumae 7g, Rhizoma Zingiberis Recens 7g.
Embodiment 2
A kind of Chinese medicine composition for the treatment of cholecystitis, cholelithiasis of the present invention, is made up of following crude drug, and the weight portion of each crude drug is: Radix Bupleuri 20g, Radix Et Rhizoma Rhei 11g, Radix Paeoniae Alba 11g, Fructus Aurantii Immaturus 11g, Radix Scutellariae 11g, Rhizoma Pinelliae 11g, Radix Curcumae 11g, Rhizoma Zingiberis Recens 11g.
Embodiment 3
A kind of Chinese medicine composition for the treatment of cholecystitis, cholelithiasis of the present invention, is made up of following crude drug, and the weight portion of each crude drug is: Radix Bupleuri 18g, Radix Et Rhizoma Rhei 9g, Radix Paeoniae Alba 9g, Fructus Aurantii Immaturus 9g, Radix Scutellariae 9g, Rhizoma Pinelliae 9g, Radix Curcumae 9g, Rhizoma Zingiberis Recens 9g.
Of the present inventionly a kind ofly treat cholecystitis, the usage and dosage of Chinese medicine composition of cholelithiasis is: a secondary Chinese medicine composition is placed in pottery, add cold water to exceeding medical surfaces 4-6cm, soak 20 minutes, after boiling with high heat, again with slow fire boiling 30-35min, the medicinal liquid decocted by head leaches down in bowl, add water in filtering residue again and exceed medicinal residues surface 3-4cm, again with slow fire boiling about 20 min, the medicinal liquid decocted two leaches, and the medicinal liquid decocted with head merges, as potion, patient takes 1-2 agent day, and sooner or later taking, 7 days is a course for the treatment of.
Wherein, of the present inventionly a kind ofly to treat in the Chinese medicine composition of cholecystitis, cholelithiasis, comprise Radix Bupleuri, Radix Et Rhizoma Rhei, the Radix Paeoniae Alba, Fructus Aurantii Immaturus, Radix Scutellariae, the Rhizoma Pinelliae, Radix Curcumae and Rhizoma Zingiberis Recens.Radix Bupleuri, Radix Et Rhizoma Rhei, the Radix Paeoniae Alba, Fructus Aurantii Immaturus, Radix Scutellariae, the Rhizoma Pinelliae, Radix Curcumae and Rhizoma Zingiberis Recens are as follows in effect pharmacologically:
Radix Bupleuri, Chinese medicine name.For the medical herbs that " Chinese Pharmacopoeia " includes, medicinal part is the dry root of umbelliferae bupleurum or Radix Bupeuri Scorzonerfolii..Spring, Qiu Erji excavate, removing stem and leaf and silt, dry.Radix Bupleuri is conventional diaphoretic medicine.Another name ground smoke, mountain dish, mushroom grass, faggot, nature and flavor hardship, be slightly cold, return liver, gallbladder meridian.There is reconciling superficies and interior, effect of soothing the liver yang invigorating.For cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterine prolapse, menoxenia.
Radix Et Rhizoma Rhei is being collectively referred to as of the perennial plant of multiple Polygonaceae Rheum, is also the title of Chinese crude drug.In the document of CHINESE REGION, the todaiwo,rhizoma often that " Radix Et Rhizoma Rhei " refers to.In China, Radix Et Rhizoma Rhei is mainly done medicinal, but in Europe and the Middle East, their Radix Et Rhizoma Rhei often refers to the Rheum kind that other several work is edible, and stem is red, gas delicate fragrance, bitter in the mouth and micro-puckery, and that chews sticks to one's teeth, and has sand feeling.Autumn Mo in the stem and leaf withered or secondary spring excavates before germinateing.Removing radicula, scrapes off crust, valve cutting or section, and rope is worn the dry or convection drying Chinese herb rhubarb of bunchiness and had effects such as attacking stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, blood stasis dispelling, removing toxic substances.
The Radix Paeoniae Alba is cool in nature, and bitter in the mouth acid, is slightly cold, has the effects such as blood-supplementing blood-nourishing, suppressing liver-YANG, easing the affected liver to relieve pain, astringing YIN to stop sweating, is applicable to fever due to yin deficiency, menoxenia, the breast abdomen pain over the hypochondriac region, extremity contraction suddenly, dysentery stomachache, spontaneous sweating, metrorrhagia, the inferior disease of band.Radix Paeoniae has antibacterial, antipyretic, antiinflammatory, increase coronary flow, improves the effect of myocardial nutritional flow, blood vessel dilating, antagonism acute myocardial ischemia, anticoagulant, calmness, analgesia, spasmolytic, antiulcer, adjustment blood glucose.Radix Paeoniae Alba decoct can suppress dysentery bacterium, streptococcus pneumoniae, escherichia coli, Bacillus typhi, Hemolytic streptococcus, bacillus pyocyaneus etc.
Fructus Aurantii Immaturus, Chinese medicine name; Belong to the dry young fruit of rutaceae Citrus aurantium Linn. and variety or Fructus Citri sinensis.Citrus aurantium Linn., Rutaceae, Citrus dungarunga, branch and leaf are dense, and thorn is many, and the thorn of the branch of excessive growth reaches 8 centimetres.Leaf color is dark green, the quite thick main product of quality in Sichuan, Jiangxi, Fujian, the ground such as Jiangsu.Pluck between 5 ~ June or gather the fruit from falling, be two halves from middle part crosscut, dry or cold drying, smaller directly dries or cold drying.Used time is clean, vexed, shave, dry.Life is used or parched with bran is used.. " medicineization justice ": " Fructus Aurantii Immaturus specially lets out excess of the stomach, and convince hard knot by patient analysis, therefore the main middle part of gastric cavity is to control blood system, treat the interventral reality of umbilicus full, expectorant addiction, dispels and cut off the water, by dyspepsia, broken blocked-up chest, relieving constipation is closed, non-this can not be also.If skin pruritus, because of hematocele stagnant in, can not nutrition flesh table, if diet is not thought, because spleen pent-up can not transporting, all get power that its pungent loose hardship rushes down also.
Radix Scutellariae another name Radix Scutellariae, tsuchikane tea root.For labiate Radix Scutellariae, be used as medicine with root.Have heat clearing and damp drying, removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.
Separablely in the Rhizoma Pinelliae obtain 15 compounds, be respectively chrysophanol, succinic acid, positive Palmitic acid-1-glyceride, hydroquinol phenol, Hydroxymethylfurfural, o-dihydroxy phenol and cupreol, daucosterol.The function of the Rhizoma Pinelliae cures mainly: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, vomiting regurgitation, and breast gastral cavity painful abdominal mass is vexed, globus hystericus; Raw with external treatment carbuncle sucutaneous nodule.The Rhizoma Pinelliae can promote rabbit bile secretion, corticosterone in Mouse Blood can be made to increase, strengthen corticosterone to the inducing action of TYR transaminase in liver, raise the activity of TYR transaminase in liver.
Radix Curcumae, Chinese medicine name.Radix Curcumae possesses promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, and clear away heart-fire removing heat from blood, promoting the function of the gallbladder to alleviate jaundice.Cure mainly for the twinge of the breast side of body, obstruction of qi in the chest and cardialgia, amenorrhea dysmenorrhea, distending pain of the breast, calentura coma, epilepsy is gone mad, and heat in blood tells nosebleed, jaundice dark coloured urine.
Rhizoma Zingiberis Recens is the fresh rhizome of Zingiberaceae herbaceos perennial Rhizoma Zingiberis Recens, high 40 ~ 100cm.Another name has race, hundred peppery clouds, hook dress refers to, because of pungent, the hot and cold boy in ground, fresh ginger, processed with honey Rhizoma Zingiberis Recens.The rhizome (Rhizoma Zingiberis) of Rhizoma Zingiberis Recens, cork (Cortex Zingiberis), leaf (Folium Zingiberis) all can be used as medicine.Rhizoma Zingiberis Recens is in Chinese medicine and pharmacy, and Rhizoma Zingiberis Recens property and flavor of peppery and warm, has the multiple efficacies such as cold expelling diaphoresis, preventing phlegm from forming and stopping coughing, stomach function regulating, preventing or arresting vomiting.
A kind of Chinese medicine composition for the treatment of cholecystitis, cholelithiasis of the present invention, can directly pulverize or through this area conventional extraction techniques if the Hydrolysis kinetics of water extracting alcohol method or alcohol water lifting method is as the active component of the compositions for the treatment of.Described active component can with pharmaceutically acceptable carrier or excipient.Wherein said pharmaceutically acceptable carrier or excipient are selected according to different agent shapes.Of the present inventionly a kind ofly treat cholecystitis, the Chinese medicine composition of cholelithiasis is prepared to tablet, capsule or oral liquid.
A kind of preparation method of oral liquid of Chinese medicine composition for the treatment of cholecystitis, cholelithiasis of the present invention, can but be not limited to following one, after active component is mixed, decoct with water, decoction liquor is filtered and obtains solution, extractum is obtained by concentrated for obtained solution, then the concentration obtained extractum being dissolved in extractum weight 8-10 times weight is in the ethanol water of by weight 95%, be uniformly mixed, quantitative separating, obtains a kind of oral liquid of Chinese medicine composition for the treatment of cholecystitis, cholelithiasis of the present invention.
A kind of preparation method of tablet of Chinese medicine composition for the treatment of cholecystitis, cholelithiasis of the present invention, is ground into fine powder after being mixed by active component, after crossing 80 ~ 120 order dusting covers, by tabletting, direct for dry powder machine is pressed into tablet.
A kind of preparation method of capsule of Chinese medicine composition for the treatment of cholecystitis, cholelithiasis of the present invention, is ground into fine powder after being mixed by active component, after crossing 80 ~ 120 order dusting covers, by filling with capsule after the operations such as granulations, drying, granulate, polishing, packing and gets product.
Clinical experiment is observed: the present invention carries out clinical observation treatment to 200 routine patients, patient is men and women's each age group, the oldest person 85 years old, age reckling only has 22 years old, be cholecystitis or Patients with Cholelithiasis, show as clinical hypochondriac pain, generate heat, detest oil, nauseating, dry stool, red tongue yellow and greasy fur, the profound cunning of arteries and veins etc.Therapeutic Method: the Chinese medicine composition of oral the preferred embodiments of the present invention 3, with being decocted in water for oral dose, 1-2 time on the one 7th is a course for the treatment of.
Efficacy assessment standard:
Cure: Clinical symptom and sign disappears, functional activity recovers normal, and pain disappears, and indices recovers normal on inspection.Effective: the basic or major part of Clinical symptom and sign disappears, and pain disappears substantially, and majority parameters recovers normal on inspection.Effective: clinical symptoms body is clearly better or takes a turn for the better, pain relief, and indices slightly takes a turn for the better on inspection.Invalid: Clinical symptom and sign thing improves, and Index for examination has no improvement.
Therapeutic effect: better for acute cholecystitis patient outcomes, general 1-3 can cure a course for the treatment of, and have 40 healings for chronic cholecystitis patient through 4-6 the course for the treatment of, 11 effective, 3 effectively, and 2 invalid.A kind of Chinese medicine composition cure rate 92% for the treatment of cholecystitis, cholelithiasis of the present invention, effectively accounts for 5.5%, effectively accounts for 1.5%, invalidly accounts for 1%, total effective rate 99%.
Typical case
Wu, female, 44 years old, people from Wuhu, on March 24th, 2013 examined, and burst upper right abdomen persistence has an intense pain and accompanies paroxysmal to increase the weight of, and scapular region radiation to the right, often have Nausea and vomiting, heating, upper right abdomen has tenderness, muscle tonus.Be diagnosed as acute cholecystitis, the Chinese medicine taking the preferred embodiments of the present invention 3 is cured 2 courses for the treatment of, does not recur so far.
Tan, man, 62 years old, people from Xiao County, on March 1st, 2014, head examined, and within 2014, Huaibei City First People's Hospital is diagnosed as chronic cholecystitis and has calculus in gallbladder, has taken some months western medicine result not obvious, in August, 2014 adopts external stone crushing curative effect very micro-, start the Chinese medicine composition taking the preferred embodiments of the present invention 3 after being introduced, with being decocted in water for oral dose, once-a-day, 4 courses for the treatment of cure, and do not recur so far.
Guo, man 22 years old, people from Changfeng County, within 2011, No.1 Reople's Hospital, Hefei City is diagnosed as urine cholelithiasis, has taken some months western medicine result not obvious, in JIUYUE, 2012 adopts external stone crushing curative effect very micro-, start the Chinese medicine composition taking the preferred embodiments of the present invention 3 after being introduced, with being decocted in water for oral dose, once-a-day, 2 courses for the treatment of cure, and do not recur so far.
A kind of Chinese medicine composition for the treatment of cholecystitis, cholelithiasis of the present invention, this Chinese medicine composition has 'Shugan Lidan ', treating stranguria by Shi Zhigong, has the effect of lithodialysis, treatment lithangiuria good effect, and instant effect is without any side effects.
To those skilled in the art, obviously the invention is not restricted to the details of above-mentioned one exemplary embodiment, and when not deviating from spirit of the present invention or basic feature, the present invention can be realized in other specific forms.Therefore, no matter from which point, all should embodiment be regarded as exemplary, and be nonrestrictive, scope of the present invention is limited by claims instead of above-mentioned explanation, and all changes be therefore intended in the implication of the equivalent component by dropping on claim and scope are included in the present invention.
In addition, be to be understood that, although this description is described according to embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should by description integrally, and the technical scheme in each embodiment also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.

Claims (7)

1. treat the Chinese medicine composition of cholecystitis, cholelithiasis for one kind, it is characterized in that, be made up of following crude drug, the weight portion of each crude drug is: Radix Bupleuri 16-20, Radix Et Rhizoma Rhei 7-11, Radix Paeoniae Alba 7-11, Fructus Aurantii Immaturus 7-11, Radix Scutellariae 7-11, Rhizoma Pinelliae 7-11, Radix Curcumae 7-11, Rhizoma Zingiberis Recens 7-11.
2. treat a Chinese medicine composition for cholecystitis, cholelithiasis, it is characterized in that, be made up of following crude drug, the weight portion of each crude drug is: Radix Bupleuri 16, Radix Et Rhizoma Rhei 7, the Radix Paeoniae Alba 7, Fructus Aurantii Immaturus 7, Radix Scutellariae 7, the Rhizoma Pinelliae 7, Radix Curcumae 7, Rhizoma Zingiberis Recens 7.
3. treat a Chinese medicine composition for cholecystitis, cholelithiasis, it is characterized in that, be made up of following crude drug, the weight portion of each crude drug is: Radix Bupleuri 20, Radix Et Rhizoma Rhei 11, the Radix Paeoniae Alba 11, Fructus Aurantii Immaturus 11, Radix Scutellariae 11, the Rhizoma Pinelliae 11, Radix Curcumae 11, Rhizoma Zingiberis Recens 11.
4. treat a Chinese medicine composition for cholecystitis, cholelithiasis, it is characterized in that: be made up of following crude drug, the weight portion of each crude drug is: Radix Bupleuri 18, Radix Et Rhizoma Rhei 9, the Radix Paeoniae Alba 9, Fructus Aurantii Immaturus 9, Radix Scutellariae 9, the Rhizoma Pinelliae 9, Radix Curcumae 9, Rhizoma Zingiberis Recens 9.
5. treat a Chinese medicine composition for cholecystitis, cholelithiasis, it is characterized in that: described Chinese medicine composition is prepared to tablet, capsule or oral liquid.
6. according to the application of the arbitrary described Chinese medicine composition of claim 1-4 in the medicine for the preparation for the treatment of treatment cholecystitis.
7. according to the application of the arbitrary described Chinese medicine composition of claim 1-4 in the medicine for the preparation for the treatment of treatment cholelithiasis.
CN201510752548.6A 2015-11-04 2015-11-04 Traditional Chinese medicine composition for treating cholecystitis and gall-stone Pending CN105250963A (en)

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CN103446555A (en) * 2012-05-30 2013-12-18 付勇 Chinese medicinal composition for treating cholecystitis
CN104815306A (en) * 2015-05-09 2015-08-05 高淑贤 Medicine for treating acute cholecystitis and preparation method thereof

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
CN1430996A (en) * 2003-01-15 2003-07-23 南通精华制药有限公司 Oral prepn. of big bupleurum root and its prodn. methods
CN103446555A (en) * 2012-05-30 2013-12-18 付勇 Chinese medicinal composition for treating cholecystitis
CN104815306A (en) * 2015-05-09 2015-08-05 高淑贤 Medicine for treating acute cholecystitis and preparation method thereof

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Application publication date: 20160120