CN1857706A - Red flavonid and production process of its medicine composition - Google Patents
Red flavonid and production process of its medicine composition Download PDFInfo
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- CN1857706A CN1857706A CN 200610066025 CN200610066025A CN1857706A CN 1857706 A CN1857706 A CN 1857706A CN 200610066025 CN200610066025 CN 200610066025 CN 200610066025 A CN200610066025 A CN 200610066025A CN 1857706 A CN1857706 A CN 1857706A
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Abstract
The present invention relates to the production process of effective Chinese medicine component, and is especially production process of tassel flower herb flavones. The present invention also relates to the production process of one medicine with function of clearing away heat and toxic material, and the medicine may be used in treating common cold, influenza, parotitis, laryngopharyngitis and other diseases. The present invention has simple preparation process, excellent preparation stability, extracts liquid as adhesive and excellent technological result.
Description
Technical field
The present invention relates to a kind of Chinese medicine production process of effective component, specifically, relate to the production method of Chinese medicine red flavonid class (Flavones) chemical constituent.The invention still further relates to a kind of medicine production method with antipyretic and antidote functions, described medicine can be used for treating diseases such as flu, influenza, parotitis, pharyngolaryngitis, tonsillitis or tracheitis.The invention belongs to field of medicaments.
Background technology
The feverfew Herba Duchesneae Indicae, it is a kind of plant amedica of a kind of treatment inflammation commonly used, mosquito bite, conjunctivitis, rheumatism, wound etc., contain Pyrrolizidine Alkaloid and flavone compound, and flavone compound is the active component of its antiinflammatory and antioxidation.
Herba Duchesneae Indicae Flavonoid substances content is higher, and Flavonoid substances is the stronger chemical compound of a class physiologically active.Herba Duchesneae Indicae has good heat-clearing and toxic substances removing and antiinflammatory pharmacological action.But the process study of Herba Duchesneae Indicae active component report is less.To the process study of the compound medicine of Herba Duchesneae Indicae also seldom.
Summary of the invention
For development and utilization Chinese medicine Herba Duchesneae Indicae effectively, the invention provides production method and the pharmaceutical composition and the medical applications of Herba Duchesneae Indicae Flavonoid substances.
For this reason, one of purpose of the present invention provides a kind of production method of red flavonid extract.
Two of purpose of the present invention provides a kind of Chinese medicine composition and production method and medical usage that contains Herba Duchesneae Indicae
For realizing purpose of the present invention, the present invention adopts following technical scheme:
A kind of method of extracting red flavonid is characterized in that comprising the step of water as the solvent extraction Herba Duchesneae Indicae.
Wherein, described extraction can be the Chinese medicine extraction method of routine, for example soaks extraction, decocts extraction or diafiltration extraction etc., and the present invention preferably adopts water boiling and extraction.
The present invention also provides a kind of Herba Duchesneae Indicae and other raw material of Chinese medicine are mixed to extract, and calculates 1000 parts of Herba Duchesneae Indicae by weight that is:, 750 parts of Herba Solidaginiss, 63 parts in Rhizoma Zingiberis Recens, 625 parts of Radix Isatidis, mixed back water extracts as solvent, and extracting solution is concentrated into clear paste.
As one of specific embodiments, the invention provides a kind of medicine production method with antipyretic and antidote functions, wherein said medicine calculates by weight, comprise following principal agent composition: 1000 parts of Herba Duchesneae Indicae, 750 parts of Herba Solidaginiss, 63 parts in Rhizoma Zingiberis Recens, 625 parts of Radix Isatidis, 375 parts in Radix Glycyrrhizae, described method comprises the steps:
(1) the mixed back of Herba Duchesneae Indicae, Herba Solidaginis and Rhizoma Zingiberis Recens water is extracted as solvent, extracting solution is condensed into clear paste;
(2) the Radix Isatidis water is extracted as solvent, extracting solution is concentrated in right amount, adds ethanol and precipitates in right amount, leaves standstill after-filtration, is condensed into clear paste behind the filtrate recycling ethanol;
(3) step (1) and the resulting clear paste of step (2) are merged, be condensed into thick paste;
(4) Radix Glycyrrhizae powder is broken into fine powder, and, makes granule Radix Glycyrrhizae fine powder and proper amount of diluting and the resulting thick paste mixing of step (3).
Term of the present invention " clear paste ", " thick paste ", except that special instruction is arranged, promptly refer to Chinese medicine extraction concentrate in term " clear paste " commonly used, " thick paste ".
Above-mentioned ethanol precipitation concentration, the alcohol amount that contains of solution can be 50%～80%, is preferably 60%～70%.
Method of the present invention, during wherein step (4) was granulated, with the water of described thick paste adding 1～2 times (weight), stirring made abundant dissolving as binding agent, makes granule with described binding agent behind Radix Glycyrrhizae fine powder and the diluent mixing.
Can adopt granulating process conventional on the preparation to granulate.As preferred version, granulation of the present invention is after Radix Glycyrrhizae fine powder and diluent are placed airpillow-dry granulator mixing, to granulate as hydrojet with above-mentioned described binding agent.
Above-mentioned resulting granules can further be made suitable preparation.For example,,, mix, carry out tabletting and make tablet with proper amount of lubricating agent with above-mentioned resulting granules as one of preferred version of the present invention.
Diluent of the present invention, it can be pharmaceutically conventional diluent components, for example include but not limited to mannitol (granular or powdery), xylitol, sorbitol, maltose, microcrystalline Cellulose, PROSOLV SMCC, polymerization sugar (EMDEX ), glucose, lactose, sucrose, dextrin and starch etc., can use separately, also can applied in any combination.
Lubricant of the present invention, it can be pharmaceutically conventional lubricant composition, for example include but not limited to magnesium stearate, calcium stearate, zinc stearate, glyceryl monostearate, Polyethylene Glycol, hydrogenated vegetable oil, sodium stearyl fumarate, polyoxyethylene monostearate, single Laurel sucrose acid ester, sodium laurylsulfate, magnesium laurylsulfate, Stepanol MG and Pulvis Talci etc., can use use also capable of being combined separately.
The medicine that above-mentioned described method prepares has the effect of heat-clearing and toxic substances removing, inflammation-diminishing and cough-controlling, can be used as heat-clearing and toxic substances removing or inflammation-diminishing and cough-controlling medicine, is used for treating diseases such as flu, influenza, parotitis, pharyngolaryngitis, tonsillitis or tracheitis.
The present invention is by the Chinese medicine extraction isolation technics and the Chinese medicine preparation technology of uses advanced, make the modern medicines preparation with what be used for heat-clearing and toxic substances removing and inflammation-diminishing and cough-controlling clinically through proved recipe, kept former composition and the effect that experience side's decoction is arranged, remove crudely and store essence, the pharmaceutical preparation that makes is conveniently taken, preparation stabilization meets medication requirement clinically.And extraction process of the present invention and preparation process are simple, and the technology cost is low, and process stabilizing is suitable for suitability for industrialized production, in the production method particularly of the present invention, find the binding agent that the employing Chinese medicine extract is used as preparation, have obtained beyond thought effect.
The specific embodiment
Following specific embodiment just in order to explain or illustrate the present invention, should not be understood that protection domain of the present invention is construed as limiting.
Embodiment 1
Herba Duchesneae Indicae 540 grams add water an amount of (about 980 grams), and about 1.5 hours of heated and boiled leaches medicinal liquid, and it is an amount of that medicinal residues add water again, and about 1.5 hours of heated and boiled merges filtrate twice, is concentrated into clear paste (relative density was 1.10～1.15 when 50 ℃ of heat were surveyed).
It is an amount of to get above-mentioned clear paste, is dissolved in water, and adds the hydrolysis of dilute sulfuric acid reflux again, puts cold back and uses ethyl acetate extraction, and as test sample, other gets the Quercetin reference substance, after testing, contains the main component of flavonoid in the above-mentioned gained clear paste.
Embodiment 2
10 kilograms of Herba Duchesneae Indicae, 7.5 kilograms of Herba Solidaginiss, 0.63 kilogram in Rhizoma Zingiberis Recens, 6.25 kilograms of Radix Isatidis are got Herba Duchesneae Indicae, Herba Solidaginis and Rhizoma Zingiberis Recens and are placed extractor, decoct with water secondary, and each 1.5 hours, collecting decoction left standstill, and got supernatant concentration and became clear paste.Other gets Radix Isatidis, decocts with water secondary, and each 1.5 hours, collecting decoction filtered, and filtrate is condensed into clear paste (relative density was 1.10～1.15 when 50 ℃ of heat were surveyed), adds ethanol and makes and contain the alcohol amount and reach 60%, and standing over night filters, and is condensed into clear paste behind the filtrate recycling ethanol.Above-mentioned gained clear paste is merged, be condensed into thick paste (relative density was 1.30～1.40 when 80 ℃ of heat were surveyed).
Embodiment 3
With the thick paste of embodiment 2 gained, according to cream: purified water=1: 1.1 (weight ratio) concentration ratio heated and stirred, make abundant dissolving, cross 80 mesh sieves, as binding agent.
Extracting liquorice is 3.75 kilograms in addition, and porphyrize becomes fine powder, crosses 100 mesh sieves.Get 0.45 kilogram in dextrin more in addition.Radix Glycyrrhizae fine powder and dextrin are dropped in the granulator, after fully mixing, are that hydrojet is carried out one-step palletizing and drying was taken out after 30 minutes with the above-mentioned binding agent that makes, and after determination of water is qualified (water content 3-7%), obtain dried granule.
According to doing 5/1000ths of particle weight, add magnesium stearate, behind the mixing, carry out tabletting, make 10000.
Prescription of the present invention is formed, and belongs to clinical experience side, determined curative effect, stable.Preparation process of the present invention is simple, and preparation stability is good, adopts extracting solution as the preparation binding agent, and technology has beyond thought technique effect.
The present invention is described according to preferred embodiment.Should be understood that the description of front and embodiment are just to illustrating the present invention.Under prerequisite without departing from the spirit and scope of the present invention, those skilled in the art can design multiple alternative of the present invention and improvement project, and it all should be understood to be within protection scope of the present invention.
Claims (10)
1, the extracting method of red flavonid is characterized in that comprising the step of water as the solvent extraction Herba Duchesneae Indicae.
2, method according to claim 1, it is characterized in that Herba Duchesneae Indicae is mixed in other medicines and extract, that is: calculate by weight, 1000 parts of Herba Duchesneae Indicae, 750 parts of Herba Solidaginiss, 63 parts in Rhizoma Zingiberis Recens, 625 parts of Radix Isatidis, mixed back water extracts as solvent, and extracting solution is concentrated into clear paste.
3, a kind of medicine production method with antipyretic and antidote functions, wherein said medicine calculates by weight, comprises following principal agent composition: 1000 parts of Herba Duchesneae Indicae, 750 parts of Herba Solidaginiss, 63 parts in Rhizoma Zingiberis Recens, 625 parts of Radix Isatidis, 375 parts in Radix Glycyrrhizae, it comprises the steps:
(1) the mixed back of Herba Duchesneae Indicae, Herba Solidaginis and Rhizoma Zingiberis Recens water is extracted as solvent, extracting solution is condensed into clear paste;
(2) the Radix Isatidis water is extracted as solvent, extracting solution is concentrated in right amount, adds ethanol and precipitates in right amount, leaves standstill after-filtration, is condensed into clear paste behind the filtrate recycling ethanol;
(3) step (1) and the resulting clear paste of step (2) are merged, be condensed into thick paste;
(4) Radix Glycyrrhizae powder is broken into fine powder, and, makes granule Radix Glycyrrhizae fine powder and proper amount of diluting and the resulting thick paste mixing of step (3).
4, the described method of claim 3, wherein in the step (4), with the water of described thick paste adding 1～2 times (weight), stirring makes abundant dissolving as binding agent, makes granule with described binding agent behind Radix Glycyrrhizae fine powder and the diluent mixing.
5, the described method of claim 4, wherein Radix Glycyrrhizae fine powder and diluent are placed airpillow-dry granulator mixing after, granulate as hydrojet with described binding agent.
6, the described method of claim 3-5 also comprises the step of mixing tablet forming behind the particle drying that will make with proper amount of lubricating agent.
7, method according to claim 6, wherein said diluent are dextrin, and described lubricant is a magnesium stearate.
8, a kind of medicine is characterized in that being prepared by the described method of claim 3-7.
9, the described medicine of claim 8 is used to prepare the purposes of heat-clearing and toxic substances removing medicine or inflammation-diminishing and cough-controlling medicine.
10, the described medicine of claim 8 is used to prepare the purposes of disease medicaments such as treatment flu, influenza, parotitis, pharyngolaryngitis, tonsillitis or tracheitis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610066025 CN1857706A (en) | 2006-03-27 | 2006-03-27 | Red flavonid and production process of its medicine composition |
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| CN 200610066025 CN1857706A (en) | 2006-03-27 | 2006-03-27 | Red flavonid and production process of its medicine composition |
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| CN 200610066025 Pending CN1857706A (en) | 2006-03-27 | 2006-03-27 | Red flavonid and production process of its medicine composition |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101019943B (en) * | 2007-03-19 | 2010-06-30 | 沈信堂 | Tonsillitis treating Chinese medicine |
| CN102798673A (en) * | 2012-07-17 | 2012-11-28 | 广西大学 | Method for identifying emilia sonchifolia medicinal material |
| CN108739099A (en) * | 2018-04-25 | 2018-11-06 | 朱定芳 | A kind of implantation methods improving tassel flower yield |
-
2006
- 2006-03-27 CN CN 200610066025 patent/CN1857706A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101019943B (en) * | 2007-03-19 | 2010-06-30 | 沈信堂 | Tonsillitis treating Chinese medicine |
| CN102798673A (en) * | 2012-07-17 | 2012-11-28 | 广西大学 | Method for identifying emilia sonchifolia medicinal material |
| CN108739099A (en) * | 2018-04-25 | 2018-11-06 | 朱定芳 | A kind of implantation methods improving tassel flower yield |
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