CN1644203A - Oral preparation of red common stone crop polysaccharide and its making method - Google Patents
Oral preparation of red common stone crop polysaccharide and its making method Download PDFInfo
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- CN1644203A CN1644203A CN 200410021702 CN200410021702A CN1644203A CN 1644203 A CN1644203 A CN 1644203A CN 200410021702 CN200410021702 CN 200410021702 CN 200410021702 A CN200410021702 A CN 200410021702A CN 1644203 A CN1644203 A CN 1644203A
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- polysaccharide
- radix rhodiolae
- rhodiola root
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Abstract
An oral compound medicine of salidroside in the form of tablet and capsule for improving immunity, decreasing blood sugar and blood fat, relieving fatigue and delaying senility is prepared from rhodiola root through extracting its polyose, salidroside and volatile oil, proportional mixing and shaping.
Description
Technical field: involved in the present invention to be the pharmaceutical preparation new technical field, especially be based upon the multiple effective site of single medicinal material extracted the modern oral formulations molding of Radix Rhodiolae polysaccharide compound recipe new technique on the purification basis respectively.
Background technology: Radix Rhodiolae is Tibetan medicine's medicinal herbs most in use, have the title of " SHENCAO ", has special efficacies such as resisting fatigue, anti-hypoxia, raising immunity because of being grown in high and cold special environment.Present exploitation preparation to the Radix Rhodiolae resource mostly is the crude preparation by using with other tonic compatibility, since generally believe that rhodioside is its main effective ingredient, therefore, to the utilization of Radix Rhodiolae, usually at the rhodioside position, a large amount of wastes of this valuable herb resource have been caused.In conjunction with our pharmacodynamic study result, this invention has been proposed to Radix Rhodiolae polysaccharide, volatilization wet goods position.This invention is a raw material with the Radix Rhodiolae single medicinal material, extracts respectively and purification polysaccharide, glycosides, flavone and volatilization wet goods effective site wherein, and compatibility has been made the various modern oral formulations based on polysaccharide according to a certain percentage.These oral formulations have tangible blood sugar lowering, blood fat reducing, and effects such as resisting fatigue, defying age and human body immunity improving power, take without any side effects for a long time.The present invention has improved the utilization rate and the rhodiola rosea formulated product bioavailability of medical material, is suitable for suitability for industrialized production.
Summary of the invention: by extraction purification to medical material polysaccharide, glycosides, flavone and volatilization wet goods effective site, made the modern oral formulations of five kinds of compound rhodiola root polysaccharide, promptly compound rhodiola root polysaccharide sheet, compound rhodiola root polyoses capsule, compound rhodiola root polysaccharide slow releasing tablet, compound rhodiola root polysaccharide slow releasing capsule, compound rhodiola root polysaccharide microcapsule capsule etc. are five kinds.
The preparation process of the modern oral formulations of compound rhodiola root polysaccharide mainly includes extraction purification and two stages of preparations shaping of imitating the position, and concrete operations are as follows:
1. the extraction purification of effective ingredient such as Radix Rhodiolae polysaccharide
1.1 the extraction of Radix Rhodiolae volatile oil part
With the Radix Rhodiolae coarse powder that originates in ground such as Tibet, Sichuan is raw material, extracts its volatile oil part with steam distillation.Raw medicinal material was soaked in water 2 hours, and according to solid-liquid ratio S: L=1: 8～15 ratio adds water to be extracted 6～～15 hours, collected oil phase, extracted the after-filtration that finishes, and kept medical material and water extract respectively, standby; Gained volatile oil is wrapped up with adjuvants such as beta-schardinger dextrin-s, the back sucking filtration that finishes, filtering residue is made volatile oil wrappage powder after washing, lyophilization, standby.
1.2 the extraction at Radix Rhodiolae polysaccharide position
Adopt the water extraction ethanol precipitation to extract Radix Rhodiolae polysaccharide.To extract medicinal residues behind the volatile oil and water according to solid-liquid ratio S: L=1: after 5～1: 12 the mixed, temperature remains on 60～100 ℃ and extracts 2～3 times down, merge all extracting solution, heating is concentrated into 1g medical material/ml ratio, in concentrated solution, add 95% ethanol again, make determining alcohol reach 60～～80% and precipitate, get the Radix Rhodiolae crude polysaccharides behind filtration, the vacuum drying, ethanol filtrate keeps standby.
The Radix Rhodiolae crude polysaccharides is redissolved with distilled water, filter out impurities, after operations such as enzyme process deproteinization, dialysis, precipitate with ethanol, washing, lyophilizing, make Radix Rhodiolae polysaccharide.
1.3 the extraction at rhodioside position
In solid-liquid ratio S: L=1: 50～～80% alcoholic solution that 5～～12 ratio adds aforementioned ethanol filtrate configuration extract 2～3 times at 30～～80 ℃ of following warm macerating, after the filtration, collect ethanol filtrate, after reclaiming ethanol, vacuum drying treatment, obtain the Radix Rhodiolae ethanol extract, wherein contain components such as rhodioside and flavonoid.
2. the making of compound rhodiola root polyoses oral preparation
2.1 the preparation of Radix Rhodiolae polysaccharide composite particles
The Radix Rhodiolae polysaccharide composite particles is divided into two kinds: i.e. plain edition composite particles and coating type composite particles, the two method for making is similar, just the former need not use coating material to handle, the coating material that the latter uses mainly is ethyl cellulose, hydroxypropyl cellulose and acrylic resin etc., is that example is illustrated with the coating type composite particles below:
Can adopt following two kinds of preparation methoies: the one, with volatile oil wrappage powder, Radix Rhodiolae polysaccharide and Radix Rhodiolae ethanol extract granulate respectively, after the Cotton seeds, fully mix, add adjuvants such as medical starch, after preparing soft material, wet grain, wet feed drying, granulate, make according to certain technology; Also volatile oil wrappage powder, Radix Rhodiolae polysaccharide and Radix Rhodiolae ethanol extract can be granulated in the lump coated processing and getting after evenly according to certain mixed.
2.2 the making of compound rhodiola root polyoses oral preparation
2.2.1 compound rhodiola root polysaccharide sheet
Plain edition Radix Rhodiolae polysaccharide composite particles is added adjuvant processing back tabletting to be made.
2.2 compound rhodiola root polyoses capsule
Plain edition Radix Rhodiolae polysaccharide composite particles direct packaging is made in capsulae vacuus.
2.3 Radix Rhodiolae polysaccharide slow releasing tablet
Coating type Radix Rhodiolae polysaccharide composite particles is added adjuvant processing back tabletting to be made.
2.4 the preparation of Radix Rhodiolae polysaccharide slow releasing capsule
Coating type Radix Rhodiolae polysaccharide composite particles direct packaging is made in capsulae vacuus.
2.5 the preparation of Radix Rhodiolae polysaccharide microcapsule capsule
Will join behind the plain edition Radix Rhodiolae polysaccharide composite particles porphyrize adopt complex coacervation or spray drying method for preparation microcapsule in sodium alginate, arabic gum or the gelatin solution, after finishing the microcapsule dry powder that obtains incapsulated and make the microcapsule capsule.
Embodiment is raw material with the Radix Rhodiolae, through screen, clean, dry, after the step process such as pulverizing, adopt positions such as method extraction, volatile oil, polysaccharide and glycosides such as steam distillation, water extract-alcohol precipitation and alcohol extracting method respectively, make appropriate dosage forms after purified, dispatch from the factory after physical and chemical inspection is qualified.
Claims (5)
1. the Radix Rhodiolae with Tibet, Sichuan and other places is the modern compound oral administration preparation of Radix Rhodiolae polysaccharide that raw material is made, it is characterized in that on the basis of extracting crude drug Radix Rhodiolae polysaccharide, glycosides and volatilization wet goods effective site respectively, behind the compatibility, make the modern oral formulations of dosage forms such as comprising compound rhodiola root polysaccharide tablet, compound rhodiola root polyoses capsule, compound rhodiola root polysaccharide slow releasing tablet, compound rhodiola root polysaccharide slow releasing capsule and compound rhodiola root microcapsule capsule according to a certain percentage.
2. the preparation method of production Radix Rhodiolae polysaccharide compound oral administration preparation as claimed in claim 1, it is characterized in that adopting following flow process to make: the medical material after will cleaning, drying, through section or pulverizing, after fully soaking, water extracts positions such as Radix Rhodiolae volatile oil, Radix Rhodiolae polysaccharide, rhodioside respectively.Wherein, with medical material and water according to S: L=1: 6～～15 ratio is extracted volatile oil part with steam distillation, and with beta-schardinger dextrin-wrap up pressed powder; Is S: L=1 with the medical material behind the extraction volatile oil according to solid-liquid ratio: 5～12 ratio is extracted the polysaccharide and the purification of dialysing with decoction and alcohol sedimentation technique, dialysis can be adopted bag filter or ultrafilter membrane, its aperture preferably is controlled at molecular weight below 1000, and the dialysis back adopts vacuum or lyophilization to get the Radix Rhodiolae polysaccharide position; For medicinal residues, with 60～～85% ethanol warm macerating, get pure extractum behind the recovery ethanol, wherein contain constituents such as rhodioside and flavone.
3. mixing according to a certain percentage after above-mentioned effective site being added adjuvant and granulating respectively, also add adjuvant according to a certain percentage behind the mixing and granulate in the lump, make compound rhodiola root polysaccharide tablet, compound rhodiola root polyoses capsule, compound rhodiola root polysaccharide slow releasing tablet, compound rhodiola root polysaccharide slow releasing capsule and compound rhodiola root polysaccharide microcapsule capsule respectively.
4. as described in the claim 3, the coating material that is adopted when its preparation slow releasing tablet, slow releasing capsule and microcapsule mainly is ethyl cellulose, hydroxypropyl cellulose and acrylic resin etc.
5. the Radix Rhodiolae polysaccharide compound oral administration preparation of preparation according to claim 1 is characterized in that it can play blood sugar lowering, blood fat reducing, and the effect of resisting fatigue, defying age, human body immunity improving power etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410021702 CN1644203A (en) | 2004-01-19 | 2004-01-19 | Oral preparation of red common stone crop polysaccharide and its making method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410021702 CN1644203A (en) | 2004-01-19 | 2004-01-19 | Oral preparation of red common stone crop polysaccharide and its making method |
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| Publication Number | Publication Date |
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| CN1644203A true CN1644203A (en) | 2005-07-27 |
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| CN 200410021702 Pending CN1644203A (en) | 2004-01-19 | 2004-01-19 | Oral preparation of red common stone crop polysaccharide and its making method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1962852B (en) * | 2006-11-27 | 2011-11-09 | 西北农林科技大学 | Use of gadol polysaccharide in preparation of antifreeze agent and its products and preparation method |
| CN104643055A (en) * | 2014-06-11 | 2015-05-27 | 韦治东 | Method for preparing rhodiola rosea healthy liquid |
| CN104987952A (en) * | 2015-05-31 | 2015-10-21 | 陕西理工学院 | Method for extracting volatile oil and salidroside from rhodiola whole herb |
| CN106359823A (en) * | 2016-08-30 | 2017-02-01 | 天津市南开医院 | Chewing gums containing herba rhodiolae extract and preparation method thereof |
-
2004
- 2004-01-19 CN CN 200410021702 patent/CN1644203A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1962852B (en) * | 2006-11-27 | 2011-11-09 | 西北农林科技大学 | Use of gadol polysaccharide in preparation of antifreeze agent and its products and preparation method |
| CN104643055A (en) * | 2014-06-11 | 2015-05-27 | 韦治东 | Method for preparing rhodiola rosea healthy liquid |
| CN104987952A (en) * | 2015-05-31 | 2015-10-21 | 陕西理工学院 | Method for extracting volatile oil and salidroside from rhodiola whole herb |
| CN104987952B (en) * | 2015-05-31 | 2021-03-02 | 陕西理工大学 | Method for extracting volatile oil and salidroside from rhodiola rosea whole plant |
| CN106359823A (en) * | 2016-08-30 | 2017-02-01 | 天津市南开医院 | Chewing gums containing herba rhodiolae extract and preparation method thereof |
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