CN1490014A - Mangiferin preparation and production thereof - Google Patents
Mangiferin preparation and production thereof Download PDFInfo
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- CN1490014A CN1490014A CNA031282474A CN03128247A CN1490014A CN 1490014 A CN1490014 A CN 1490014A CN A031282474 A CNA031282474 A CN A031282474A CN 03128247 A CN03128247 A CN 03128247A CN 1490014 A CN1490014 A CN 1490014A
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- mangifera indicae
- fructus mangifera
- general glycoside
- glycoside
- mengiferin
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Abstract
An orally applied chimonin preparation for relieving cough and dispelling phlegm is prepared from mango leaf or almond leaf through extracting. Its advantage is high curative effect.
Description
Technical field:
The present invention relates to a kind of Chinese medicine preparation and production method thereof with cough-suppressing phlegm-dispelling functions.
Background technology:
Fructus Mangifera Indicae (Mangifera indica linn) and almond (Mangifera persiciformis C.Y.Wuet T.L.Ming) are and grow in the torrid zone and semi-tropical fruit tree, extensively are distributed in the provinces and regions such as Hainan, Guangxi, Guangdong of China; Guangxi Zhuang Autonomous Region is one of main product ground of Fructus Mangifera Indicae, also is the fruit tree that Guangxi is given priority to, and Tiandong County, area, Baise, Tianyang County are once by national Ministry of Agriculture called after " township of Fructus Mangifera Indicae ".China has the Folium mangiferae of up to ten million ton and almond leaf to be used as firewood by the orchard worker to burn, cause the significant wastage of resource every year.
The composition of Folium mangiferae and almond leaf is quite similar, all contain compositions such as Mengiferin, isomangiferin, homomangiferin, new Mengiferin and gallic acid, the modern pharmacology research structure is verified, and Mengiferin, isomangiferin, homomangiferin and new Mengiferin (hereinafter to be referred as " Fructus Mangifera Indicae general glycoside ") are the eliminating phlegm and stopping cough effective ingredient of Folium mangiferae and almond leaf.
At present, only be a kind of cough suppressing medicine of development of raw materials with the Folium mangiferae, it is a kind of Chinese medicine and western medicine compound preparation, its composition is: Folium mangiferae water is promoted cream, chlorphenamine, Sodium Houttuyfonate.Chlorphenamine wherein has antitussive effect, and Sodium Houttuyfonate has antiinflammation.Also also have some to contain the product of Mengiferin, for example (above product are used for the treatment of hepatopathy) such as Yiganling, YUGAN spirit, Herba Abri hepatitis electuary, jaundice Herba Artemisiae Scopariae granule, ZANGYINCHEN capsules on the market; Peaceful, the multiple pancreas sugar of blood sugar lowering disappears etc. (above product is used for the treatment of diabetes) yearningly, and ZHIBAI DIHUANG WAN, Radix Rehmanniae Pilulae for Improving Eyesight, Herba Artemisiae Scopariae five Siberian cocklebur balls, lithagogue infusion etc.Though more than these products contain Mengiferin, do not produce, but produce as Herba Artemisiae Scopariae, ZANGYINCHEN, the Rhizoma Anemarrhenae, river deer dish, Rhizoma Belamcandae etc., and they are not to be used for relieving cough and resolving phlegm with other Chinese herbal medicine that contains Mengiferin with Folium mangiferae or almond leaf.
Through patent retrieval, purpose is not also found single with Folium mangiferae or almond leaf, is the medicine of main material production with Folium mangiferae or almond leaf perhaps.
Summary of the invention:
The purpose of this invention is to provide a kind of existing resource that makes full use of, turn waste into wealth, have the Fructus Mangifera Indicae general glycoside preparation and the production method thereof of cough-suppressing phlegm-dispelling functions with Folium mangiferae or the production of almond leaf.
The technical solution used in the present invention is:
Form a kind of Chinese medicine preparation by " Fructus Mangifera Indicae general glycoside " and adjuvant with cough-suppressing phlegm-dispelling functions." Fructus Mangifera Indicae general glycoside " is the composition with cough-suppressing phlegm-dispelling functions, and it is the effective site that has cough-suppressing phlegm-dispelling functions in Folium mangiferae or the almond leaf.The Fructus Mangifera Indicae general glycoside extracts from Folium mangiferae or almond leaf, the mixture of various glycoside compounds.Its main component is a Mengiferin, because of the difference of extraction process, also contains isomangiferin, homomangiferin, new Mengiferin and gallic acid sometimes; The present invention does not add or adds proper quantity of medicinal auxiliary material based on this glycoside mixture, is prepared into preparation or the dosage form that oral administration is used by common pharmaceutical technology.Adjuvant only play figuration, anticorrosion, compose effects such as perfume, flavoring, adjuvant is to choose from the pharmaceutic adjuvant that the world or China stipulate.That said preparation has is antibiotic, antiinflammatory, eliminate the phlegm, antitussive action, can be used for treating flu and wait excessive phlegm, cough and various oral inflammation and the laryngopharyngitis that causes.
The composition and the weight percentage of Fructus Mangifera Indicae general glycoside preparation of the present invention following (following composition is in dry):
Fructus Mangifera Indicae general glycoside 0.01～100%
Adjuvant 0～99.99%
The present invention extracts the active ingredient " Fructus Mangifera Indicae general glycoside " of its eliminating phlegm and stopping cough from Fructus Mangifera Indicae or almond leaf, the content summation of various glycoside reaches more than 50% in " Fructus Mangifera Indicae general glycoside ".The prepared Chinese medicine preparation of the present invention, the experiment structure shows to have good eliminating phlegm and stopping cough effect.
General process of Chinese medicine preparation is taked in the production of eliminating phlegm and stopping cough Chinese medicine preparation of the present invention, the extract that contains Mengiferin can be made preparation or the dosage form that different oral administration is used: tablet, capsule, granule, oral liquid or buccal tablet.
Eliminating phlegm and stopping cough Chinese medicine preparation of the present invention can be a primary raw material with " Fructus Mangifera Indicae general glycoside ", adds other medicines compatibility with it, makes Chinese traditional compound medicine.
Production method of the present invention is: Folium mangiferae or almond leaf extract with the ethanol water more than 45%, concentrate the back and extract the liposoluble constituent of removing in the concentrated solution with non-polar organic solvent, and the ethanol water of reuse more than 90% extracts, and obtains the Fructus Mangifera Indicae general glycoside.
The present invention has the following advantages:
1, Fructus Mangifera Indicae general glycoside preparation of the present invention is pure Chinese medicine, rather than the Chinese medicine and western medicine compound preparation.
2, Fructus Mangifera Indicae general glycoside preparation has the active constituent content height, and taking dose is little, the characteristics that toxicity is little and efficient, quick-acting.
3, production technology of the present invention can extract the high glycoside material of content from Folium mangiferae and almond leaf, the total content of glycoside material that has cough-suppressing phlegm-dispelling functions in the extract is up to more than 50%.Both made full use of abundant fruit leaf resource, and turned waste into wealth, the total salidroside content of the Fructus Mangifera Indicae of producing is high again, has economic worth.
The specific embodiment:
Be described further below in conjunction with embodiment.
1, the preparation of " Fructus Mangifera Indicae general glycoside "
Adopt common pharmaceutical technology and method from Folium mangiferae or almond leaf, to extract active ingredient " Fructus Mangifera Indicae general glycoside " in the production with eliminating phlegm and stopping cough.The design of extraction process is a principle with the effective site that extracts eliminating phlegm and stopping cough, the Main Ingredients and Appearance that is " the Fructus Mangifera Indicae general glycoside " of final gained is a Mengiferin, can contain one or more of following composition sometimes: isomangiferin, homomangiferin, new Mengiferin and gallic acid.Folium mangiferae and almond leaf can adopt dry product or bright product.
Method one
Dried Folium mangiferae is processed into fragment, with 50% ethanol water reflux, extract, 2 times, and each 2 hours.Add 50% ethanol water of 10 times of amounts the 1st time, add 50% ethanol water of 8 times of amounts the 2nd time.Merge reflux extracting liquid, filter; Reclaim the ethanol to 1 in the filtrate: (medical material: concentrated solution about 1, g: ml), remove chlorophyll, reconcentration to 1: (medical material: enrichment about 0.5 with ethyl acetate extraction, g: ml), add 5 times to 95% ethanol of concentrated solution, reflux, extract, filters while hot, reclaim the ethanol in the filtrate, the elimination mother solution, the extract obtained Mengiferin that mainly contains also contains a spot of isomangiferin, homomangiferin, new Mengiferin and gallic acid; Wherein, the content summation of various glycoside reaches more than 50%.
Method two
With the dried Folium mangiferae in the dried almond leaf replacement method one, the extract obtained Mengiferin that mainly contains also contains a spot of isomangiferin, homomangiferin, new Mengiferin and gallic acid; Wherein, the content summation of various glycoside reaches more than 50%.
Method three
Bright Folium mangiferae, chopping, 50% ethanol water extracts, and extracting solution is condensed into thick paste, and thick paste melts with hot water, removes chlorophyll with Petroleum ether extraction, adds clean fluvial sand, bakes dried cream.Dried cream pulverizes, and uses 95% ethanol extraction, and merge extractive liquid, reclaims ethanol, and the extract obtained Mengiferin that mainly contains also contains a small amount of isomangiferin, homomangiferin, new Mengiferin and gallic acid; Wherein, the content summation of various glycoside reaches more than 50%.
Method four
With the bright Folium mangiferae in the bright almond leaf replacement method three, the extract obtained Mengiferin that mainly contains also contains a spot of isomangiferin, homomangiferin, new Mengiferin and gallic acid; Wherein, the content summation of various glycoside reaches more than 50%.
Method five
More than the extract of four method gained, as washing, can remove gallic acid wherein with 95% cold ethanol, the extract obtained Mengiferin that mainly contains also contains a spot of isomangiferin, homomangiferin, new Mengiferin and gallic acid; Wherein, the content summation of various glycoside reaches more than 50%.
2, the production instance of Mengiferin preparation
Example one
Above method one gained " Fructus Mangifera Indicae general glycoside " adds appropriate amount of starch, granulates, and tablet forming, the heavy 0.3g of plain sheet, every is equivalent to 10g crude drug (dried Folium mangiferae or dried almond leaf).
Example two
Above method two gained " Fructus Mangifera Indicae general glycoside " is pulverized, and does not add adjuvant, 0 capsule of directly packing into, and every capsules is equivalent to 10g raw medicinal herbs (dried Folium mangiferae or dried almond leaf).
Example three
Above method gained " Fructus Mangifera Indicae general glycoside " adds suitable quantity of water soluble starch and Borneolum Syntheticum, is pressed into sublingual lozenge.
The pharmacodynamic action test
To the eliminating phlegm and stopping cough Chinese medicine preparation (following abbreviate as respectively " tablet " and " capsule ") of above example one and example two gained, entrust pharmacology teaching and research room of Guangxi Medical University to experimentize.Experimental result shows that the total preparation of Fructus Mangifera Indicae draws the mice that coughs and citric acid is drawn the Cavia porcellus that coughs ammonia tangible antitussive effect; Obviously reduce the phenol red excretion amount of mice; Obviously reduce the expectoration amount of rat; Nebulization to the Cavia porcellus that breathes heavily there is tangible anti-asthmatic action; The mice ear model there is tangible antiinflammatory action.Experiment showed, that Fructus Mangifera Indicae general glycoside preparation has good cough-relieving, relievings asthma, resolve phlegm effect, certain antiinflammatory action is arranged simultaneously, with the dried cream effect of clinical observation Folium mangiferae basically identical.
Toxicity test
The eliminating phlegm and stopping cough Chinese medicine preparation that above example one and example two are produced entrusts pharmacology teaching and research room of Guangxi Medical University to carry out toxicological experiment.The result shows, is subjected to reagent not have acute toxicity and long term toxicity to react, and does not detect LD
50
Clinical effectiveness
The present invention carries out the clinical practice experiment on one's body 4 routine patients, and clinical structure all is chosen as " produce effects ".One of them case is as follows:
Open * *, woman, Nanning people from city, 38 years old, readme: cough ant phlegm.Tcm diagnosis: affection of exogenous wind-cold.Western medicine diagnose: upper respiratory tract infection.Take the tablet that above example one makes, every day 3 times, each 3.After the medication 3 days.Clinical therapeutic efficacy is assessed as " produce effects ".
Claims (7)
1, a kind of Fructus Mangifera Indicae general glycoside preparation is characterized in that it contains Fructus Mangifera Indicae general glycoside and adjuvant, and its composition and weight percentage are as follows:
Fructus Mangifera Indicae general glycoside 0.01～100%
Adjuvant 0～99.99%.
2, a kind of production method of Fructus Mangifera Indicae general glycoside preparation is characterized in that: the Fructus Mangifera Indicae general glycoside extracts from Folium mangiferae or almond leaf, the mixture of various glycoside compounds.
3, Fructus Mangifera Indicae general glycoside preparation according to claim 1 is characterized in that: described adjuvant is to choose from the pharmaceutic adjuvant of the world or China's regulation.
4, Fructus Mangifera Indicae general glycoside preparation according to claim 1 is characterized in that: the extract that contains Mengiferin can be made preparation or the dosage form that different oral administration is used: tablet, capsule, granule, oral liquid or buccal tablet.
5, Fructus Mangifera Indicae general glycoside preparation according to claim 1 is characterized in that: can be primary raw material with the Fructus Mangifera Indicae general glycoside, add other medicines compatibility with it, make Chinese traditional compound medicine.
6, Fructus Mangifera Indicae general glycoside preparation according to claim 1, it is characterized in that: the main component of Fructus Mangifera Indicae general glycoside is a Mengiferin, also contains one or more of following composition sometimes: isomangiferin, homomangiferin, new Mengiferin and gallic acid.
7, the production method of Fructus Mangifera Indicae general glycoside preparation according to claim 2, it is characterized in that: Folium mangiferae or almond leaf extract with the ethanol water more than 45%, concentrate the back and extract the liposoluble constituent of removing in the concentrated solution with non-polar organic solvent, the ethanol water of reuse more than 90% extracts, and obtains the Fructus Mangifera Indicae general glycoside.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031282474A CN100528170C (en) | 2003-06-26 | 2003-06-26 | Mangiferin preparation and production thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031282474A CN100528170C (en) | 2003-06-26 | 2003-06-26 | Mangiferin preparation and production thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1490014A true CN1490014A (en) | 2004-04-21 |
| CN100528170C CN100528170C (en) | 2009-08-19 |
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ID=34153291
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB031282474A Expired - Fee Related CN100528170C (en) | 2003-06-26 | 2003-06-26 | Mangiferin preparation and production thereof |
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| Country | Link |
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| CN (1) | CN100528170C (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1332968C (en) * | 2005-07-27 | 2007-08-22 | 李学坚 | Mangiferin derivatives and its prepn. method, and use as medicine |
| CN100450991C (en) * | 2006-10-13 | 2009-01-14 | 福州大学 | Process for preparing peach leaf mandelic acid extract |
| CN103768112A (en) * | 2012-10-26 | 2014-05-07 | 昆明制药集团股份有限公司 | Mango leaf extract and application thereof |
| CN106913650A (en) * | 2017-03-31 | 2017-07-04 | 云南润嘉药业有限公司 | The preparation method of almond extract and the almond extract prepared with it |
-
2003
- 2003-06-26 CN CNB031282474A patent/CN100528170C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1332968C (en) * | 2005-07-27 | 2007-08-22 | 李学坚 | Mangiferin derivatives and its prepn. method, and use as medicine |
| CN100450991C (en) * | 2006-10-13 | 2009-01-14 | 福州大学 | Process for preparing peach leaf mandelic acid extract |
| CN103768112A (en) * | 2012-10-26 | 2014-05-07 | 昆明制药集团股份有限公司 | Mango leaf extract and application thereof |
| CN103768112B (en) * | 2012-10-26 | 2016-09-07 | 昆药集团股份有限公司 | A kind of mango leaf extract and application thereof |
| CN106913650A (en) * | 2017-03-31 | 2017-07-04 | 云南润嘉药业有限公司 | The preparation method of almond extract and the almond extract prepared with it |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100528170C (en) | 2009-08-19 |
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Granted publication date: 20090819 Termination date: 20120626 |