CN1201804C - Medicine for treating osteoporosis and its preparation method - Google Patents
Medicine for treating osteoporosis and its preparation method Download PDFInfo
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- CN1201804C CN1201804C CNB031276105A CN03127610A CN1201804C CN 1201804 C CN1201804 C CN 1201804C CN B031276105 A CNB031276105 A CN B031276105A CN 03127610 A CN03127610 A CN 03127610A CN 1201804 C CN1201804 C CN 1201804C
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Abstract
The present invention relates to a medicine for treating osteoporosis and a preparation method, particularly to a medicine for treating osteoporosis. The medicine is prepared by the following steps: grinding hairy antler, partially prepared fleeceflower root, human placenta and Radix Notoginseng into fine powder; processing the partially prepared fleeceflower root by ethanol through reflux extraction to obtain extraction solutions; merging and filtering the extraction solutions, recovering the ethanol, decocting tortoiseshell with water, and then filtering for reserving; extracting the volatile oil of Chinese angelica and amomum fruit with the water; collecting the volatile oil, coating by beta-cyclodextrin later, and then distilling to obtain a water solution; collecting the water solution in other implements for reserving; decocting eucommia bark and dried leech with the water, and then filtering to obtain a filtration solution; placing the filtration solution, mixing herb residues with the reserved herb residues, decocting with the water later, and then filtering; merging the decoction solutions, mixing with the paste extracted by the ethanol later and then adding the fine powder. The medicine of the present invention has the advantages of conspicuous curative effect and relieved side effect on multiple medicine combination.
Description
The present invention relates to the osteoporotic medicine of a kind of treatment.It specifically is the Chinese patent medicine of feedstock production with the Chinese herbal medicine.The invention still further relates to the preparation method of this medicine.
Osteoporosis is a common clinical, one of frequently-occurring disease.Up to nearly attention that just obtained people in 15 years gradually.This sick old people sees more, it is reported, nearly 200,000,000 people in the whole world suffer from osteoporosis at present, and its sickness rate has leapt to the 7th of the various commonly encountered diseases in the world.The sickness rate of China some areas senile osteoporosis disease more than 60 years old reaches 59.87%.International medical community is osteoporosis and hypertension, arteriosclerosis, and diabetes, tumor are listed as old people's important diseases.
Osteoporosis is a systemic disease, and the course of disease is long, and reaches 9.6% because of the incidence rate of the concurrent fracture of osteoporosis.The medical expense that fracture not only makes country and individual bear increases greatly, and has a strong impact on old people's quality of life.Osteoporosis is to reduce and the osseous tissue microstructure is a feature with whole body bone amount, and causes that the fragility of bone increases, and the intensity of bone lowers, in no wound, under the slight and moderate wound situation, the disease that the risk of fractures degree increases, bone mineral and bone matrix equal proportion minimizing this moment.
There is following thorny problem in the domestic and international at present Drug therapy to primary disease:
1 heavy dose of calcium preparation+vitamin D life-time service complication height, weak curative effect.
2 gonadal hormone have potential carcinogenic danger.
Can 3 calcitonins can only the intestinal external administration, costs an arm and a leg, long term administration remain to be observed.
4 diphosphonate adverse effectes are more, and effect is undesirable separately.
Though the Chinese patent medicine of some treatment osteoporosis is also arranged, Chinese medicine calcium preparation, or function blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, patent medicine such as Shujin bone strengthening and warming and recuperating the kidney-YANG, because of its function singleness, curative effect is then unsatisfactory.
The purpose of this invention is to provide a kind of osteoporotic pure Chinese medicinal preparation of treatment that stops and alleviate the degeneration of muscles and bones.
Another object of the present invention provides the preparation method of this osteoporosis preparation.
The traditional theory that solution of the present invention is based on motherland's medical science is the basis, in conjunction with the common disease type of clinical osteoporosis, with reference to the modern pharmacological research achievement, from motherland's medicine treasure-house, filter out liver and kidney tonifying, expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling, the natural drug of promoting the circulation of QI to relieve pain, by the theory of Chinese medical science prescription, skim the cream off milk, give full play to its invigorating the kidney and strengthening the bones, the merit of promoting blood circulation and stopping pain.With pure compound Chinese medicinal preparation, promptly remedied the deficiency of Western medicine, satisfied curative effect is arranged again.
Medicine of the present invention is made by following raw materials according: (consumption is a weight portion)
Cornu Cervi Pantotrichum 2～8 Radix Polygoni Multiflori Preparatas 20～30 Carapax Et Plastrum Testudiniss 18～32
The Cortex Eucommiae 10～25 Placenta Hominiss 5～15 Radix Angelicae Sinensis 10～20
Radix Notoginseng 5～15 Hirudos 3～8 Fructus Amomis 7～15
Raw material preferred weight (part) ratio range of preparation medicine of the present invention is:
Cornu Cervi Pantotrichum 3～6 Radix Polygoni Multiflori Preparatas 22～28 Carapax Et Plastrum Testudiniss 21～29
The Cortex Eucommiae 15～20 Placenta Hominiss 6～10 Radix Angelicae Sinensis 13～17
Radix Notoginseng 5～10 Hirudos 3～5 Fructus Amomis 7～10
The optimum weight of medicine of the present invention (part) proportioning is:
Cornu Cervi Pantotrichum 6 Radix Polygoni Multiflori Preparatas 24 Carapax Et Plastrum Testudiniss 24
The Cortex Eucommiae 18 Placenta Hominiss 6 Radix Angelicae Sinensis 14
Radix Notoginseng 6 Hirudos 3.5 Fructus Amomis 8
Above-mentioned each raw material is made this medicine production method is: get the said medicine raw material by weight preparation, Cornu Cervi Pantotrichum, three/a Radix Polygoni Multiflori Preparata, Placenta Hominis, Radix Notoginseng powder are broken into fine powder; Again with two parts of Radix Polygoni Multiflori Preparatas of its excess-three branch with 70% alcohol reflux secondary, each 2 hours, make a living 7 times of dose of alcohol adding amount, merge extractive liquid, filters, and reclaims ethanol, being concentrated into relative density is the thick paste shape of 1.28-1.30 (60 ℃ of surveys), and Carapax Et Plastrum Testudinis decocts with water three times, extracts 3 successively, 2,2 hours, make a living 8 times of dose of amount of water merge decoction liquor, filter standby, Radix Angelicae Sinensis, Fructus Amomi adds five times of water extraction volatile oil, collects volatile oil and carries out enclose with beta-schardinger dextrin-, and distillation rear solution device is in addition collected, collect standby, the Cortex Eucommiae, Hirudo adds ten times of water gagings, decocts two hours, filters, filtrate is placed, medicinal residues mix with above-mentioned standby medicinal residues, add the octuple water gaging, decoct two hours, filter, merge above-mentioned each decoction liquor, being concentrated into relative density is the thick paste shape of 1.28-1.30 (60 ℃ of surveys), merges with above-mentioned alcohol extraction cream, add above-mentioned fine powder, mixing is made granule, drying, incapsulate, promptly.
The clinical use result of the present invention shows that following advantage is arranged:
1. to select natural Chinese medicinal herb for use be raw material in the present invention, based on the traditional theory of motherland's medical science, and in conjunction with the common disease type of clinical osteoporosis, with reference to the modern pharmacological research achievement, reasonable formula, and through animal and clinical experiment, have no side effect.
2. the present invention is capsule, and is easy to carry, and taking convenience is removed the inconvenience of Chinese medicine decoction from.
3. the present invention uses separately through clinic trial, and is evident in efficacy, takes for a long time and do not find untoward reaction.Remove the untoward reaction that multiple medicines share from, and mutual ill effect between the medicine.
4. the present invention can replace expensive calcitonin, takes for a long time and can reduce medical expense greatly.
The specific embodiment:
Get Cornu Cervi Pantotrichum 60 gram, Radix Polygoni Multiflori Preparata 60 grams, Placenta Hominis 60 grams, Radix Notoginseng 60 grams and be ground into fine powder; Again with 180 parts of usefulness of Radix Polygoni Multiflori Preparata, 70% alcohol reflux secondary, each 2 hours, make a living 7 times of dose of alcohol adding amount, merge extractive liquid, filters, and reclaims ethanol, being concentrated into relative density is the thick paste shape of 1.30 (60 ℃ of surveys), and Carapax Et Plastrum Testudinis 240 grams decoct with water three times, extract 3 successively, 2,2 hours, make a living 8 times of dose of amount of water merge decoction liquor, filter standby, Radix Angelicae Sinensis 140 grams, Fructus Amomi 80 grams add five times of water extraction volatile oil, collect volatile oil and carry out enclose with beta-schardinger dextrin-, and distillation rear solution device is in addition collected, collect standby, the Cortex Eucommiae 180 gram, Hirudo 35 grams add ten times of water gagings, decoct two hours, filter, filtrate is placed, and medicinal residues mix with above-mentioned standby medicinal residues, add the octuple water gaging, decocted two hours, filter, merge above-mentioned each decoction liquor, being concentrated into relative density is the thick paste shape of 1.30 (60 ℃ of surveys), merge with above-mentioned alcohol extraction cream, add above-mentioned fine powder, mixing is made granule, dry, incapsulate, make 1000, promptly.
Claims (4)
1, the osteoporotic medicine of a kind of treatment is characterized in that it is the medicament of being made by the following weight proportion raw material:
Cornu Cervi Pantotrichum 2～8 Radix Polygoni Multiflori Preparatas 20～30 Carapax Et Plastrum Testudiniss 18～32
The Cortex Eucommiae 10～25 Placenta Hominiss 5～15 Radix Angelicae Sinensis 10～20
Radix Notoginseng 5～15 Hirudos 3～8 Fructus Amomis 7～15.
2, the osteoporotic medicine of treatment according to claim 1, wherein the weight proportion of each raw material is:
Cornu Cervi Pantotrichum 3～6 Radix Polygoni Multiflori Preparatas 22～28 Carapax Et Plastrum Testudiniss 21～29
The Cortex Eucommiae 15～20 Placenta Hominiss 6～10 Radix Angelicae Sinensis 13～17
Radix Notoginseng 5～10 Hirudos 3～5 Fructus Amomis 7～10.
3, the osteoporotic medicine of treatment according to claim 1, wherein the weight proportion of each raw material is:
Cornu Cervi Pantotrichum 6 Radix Polygoni Multiflori Preparatas 24 Carapax Et Plastrum Testudiniss 24
The Cortex Eucommiae 18 Placenta Hominiss 6 Radix Angelicae Sinensis 14
Radix Notoginseng 6 Hirudos 3.5 Fructus Amomis 8.
4, according to the preparation method of claim 1, the osteoporotic medicine of 2 or 3 described treatments, it is characterized in that:
Get the said medicine raw material by weight preparation, Cornu Cervi Pantotrichum, three/a Radix Polygoni Multiflori Preparata, Placenta Hominis, Radix Notoginseng powder are broken into fine powder; Again with two parts of Radix Polygoni Multiflori Preparatas of its excess-three branch with 70% alcohol reflux secondary, each 2 hours, make a living 7 times of dose of alcohol adding amount, merge extractive liquid, filters, and reclaims ethanol, being concentrated into relative density is the thick paste shape of 1.28-1.30, and Carapax Et Plastrum Testudinis decocts with water three times, extracts 3 successively, 2,2 hours, make a living 8 times of dose of amount of water, merge decoction liquor, filter standby, Radix Angelicae Sinensis, Fructus Amomi adds five times of water extraction volatile oil, collect volatile oil and carry out enclose with beta-schardinger dextrin-, distillation rear solution in addition device is collected, collect standby, the Cortex Eucommiae, Hirudo adds ten times of water gagings, decocted two hours, filter, filtrate is placed, and medicinal residues mix with above-mentioned standby medicinal residues, add the octuple water gaging, decocted two hours, and filtered, merge above-mentioned each decoction liquor, being concentrated into relative density is the thick paste shape of 1.28-1.30, merge with above-mentioned alcohol extraction cream, add above-mentioned fine powder, mixing, make granule, drying.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031276105A CN1201804C (en) | 2003-06-27 | 2003-06-27 | Medicine for treating osteoporosis and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031276105A CN1201804C (en) | 2003-06-27 | 2003-06-27 | Medicine for treating osteoporosis and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1475252A CN1475252A (en) | 2004-02-18 |
| CN1201804C true CN1201804C (en) | 2005-05-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB031276105A Expired - Fee Related CN1201804C (en) | 2003-06-27 | 2003-06-27 | Medicine for treating osteoporosis and its preparation method |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104906499A (en) * | 2015-06-26 | 2015-09-16 | 吴强 | Medicine for treating osteoporosis caused by liver-kidney yin deficiency and preparation method of medicine |
| CN105381283A (en) * | 2015-11-30 | 2016-03-09 | 杨登新 | Chinese herbal preparation for treating osteoporosis and preparation method of Chinese herbal preparation |
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Owner name: HU NAN QIU ZEYOU PATENT STRATEGIC PLANNING CO., LT Free format text: FORMER OWNER: QIU ZEYOU Effective date: 20101101 |
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Free format text: CORRECT: ADDRESS; FROM: 410011 28/F, SHUNTIANCHENG, NO.59, SECTION 2 OF FURONG MIDDLE ROAD, CHANGSHA CITY, HU NAN PROVINCE TO: 410205 JUXING INDUSTRY BASE, NO.8, LUJING ROAD, CHANGSHA HIGH-TECH. DEVELOPMENT ZONE, YUELU DISTRICT, CHANGSHA CITY, HU NAN PROVINCE |
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Effective date of registration: 20101105 Address after: 130012 No. 358, Chuangxin Road, hi tech Zone, Jilin, Changchun Patentee after: Pharmaceutical Factory, Bethune Medical Univ. Address before: 130021 Department of Orthopaedics, Changchun Provincial Hospital of traditional Chinese medicine, 1478 workers' road, Jilin, China Co-patentee before: Zhang Wentai Patentee before: Leng Xiangyang Co-patentee before: Zhao Zhongmin |
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