CN104906499A - Medicine for treating osteoporosis caused by liver-kidney yin deficiency and preparation method of medicine - Google Patents
Medicine for treating osteoporosis caused by liver-kidney yin deficiency and preparation method of medicine Download PDFInfo
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Abstract
The invention discloses a medicine for treating osteoporosis caused by liver-kidney yin deficiency and a preparation method of the medicine. The medicine comprises the following medicinal materials: purpleflower holly fruits, pork liver, lamb liver, deer horn, wolfberry fruit, clove, teasel root, radix achyranthis bidentatae, fructus amomi, flatstem milkvetch seed, mulberry, spina date seed, korean pine seed, walnut kernel, codonopsis convolvulacea, lucid ganoderma, bamboo juice, human placenta, bloody clam, rhizoma cibotii, sugarcane, astilbe chinensis, parabarium micranthum pierre, pyrola, divaricate saposhnikovia root, oat grass, unpleasant swallowwort herb, cowpea, tendrilleaf solomonseal rhizome, herminium monorchis and turtle meat. The medicine has the efficacies of tonifying the liver, benefiting the kidneys, benefiting qi, nourishing blood, strengthening tendons and bones, tonifying qi, strengthening exterior, nourishing yin and nourishing the kidneys, and is mainly used for treating osteoporosis caused by liver-kidney yin deficiency. The medicine is based on the theory of the traditional Chinese medicine, emphasizes the holistic view is stressed and has the function of relieving the problem of bones by adjusting the whole body; and the medicine is capable of restoring bone health, relieving pain, and improving the symptoms of osteoporosis, and is safe, effective, convenient to take, good in treatment effect, fast in acting, low in recurring rate and free of side effects.
Description
Technical field
The present invention relates to the medicinal preparation containing deriving from plant, animal or raw mineral materials, particularly one treats osteoporotic medicine of liver-kidney yin deficiency and preparation method thereof.
Background technology
Osteoporosis be a kind of with Low BMD and osseous tissue Microstructure Fracture for feature, cause sclerotin fragility to increase and be easy to the general bone metabolic disease of fracturing.Primary disease is common in old people, but each period at age all can fall ill.Osteoporosis can be divided into constitutional and Secondary cases two class.Primary osteoporosis means other illness of not accompanying and causing primary disease; Secondary osteoporosis is then that the osseous tissue amount caused due to various general or endocrine metabolism disease reduces.In addition, limitation or general property osteoporosis can be also divided into by happening part.
Symptom and sign: uncomplicated osteoporosis itself, there is no the symptoms such as pain, also without signs such as deformities.Early discovery primary disease relies on bone density inspection.Vertebral body x-ray plain film is abnormal is later than bone density prompting, but early than the prompting of symptom and sign.Usually there is vertebral compression fracture unconsciously, also can bring out vertebral fracture because of cough, sneeze, microtrauma etc.In several weeks of fresh vertebral fracture, occurring local pain, there is percussion pain in sign.Multiple Vertebral Compression person, occurs bow-backed (arched), and height becomes short.During non-vertebral fracture, pain and deformity show more serious.
The pathology cause of disease:
The cause of disease of primary osteoporosis is not bright, may with following a kind or several factors relevant.
1. endocrine function not normal (1) sex hormone deficiency: estrogen and (or) hypoandrogenism and out of proportion, cause: 1. protein synthesis reduces, bone matrix generates not enough; 2. function of osteoblast declines; 3. PTH increases the sensitivity of bone effect; 4. glucocorticoids on bone action intensity increases relatively; 5. intestinal calcium absorption and renal tubules calcium heavily absorb reduction, and the osteoporosis that menopause, senile and premature ovarian failure etc. cause all may be relevant therewith, and estrogen deficiency may be the main cause of menopausal osteoporosis.(2) PTH secretion increasing: the blood PTH of some primary osteoporosis (bone high-conversion rate osteoporosis) person slightly increases, this is more obvious in the patient of senile renal hypofunction and impaired glucose tolerance; Add the reasons such as sex hormone deficiency, PTH and gonadal hormone ratio are not normal, can osteoporosis be caused.(3) calcitonin (CT) lacks: after menopause, CT level reduces, and may facilitate osteoporotic generation because suppressing bone resorption factor reduction.(4) other functionss of hormones: some data show, there is the diacrisis of thyroxin, glucocorticoid, growth hormone, Lifestyle factor (especially somatomedin C), gastrin in patients with primary osteoporosis, but its causal significance is not illustrated.
2. malnutrition is due to a variety of causes, and old people, adolescence and edge design malnutrition can occur.Protein undersupply may cause osteogenesis obstacle, but take in too much protein also make urine calcium discharge increase, cause calcium negative balance.The Deficiency of Intake of calcium and osteoporotic in close relations, low calcium diet can cause bone resorption to accelerate by Secondary cases PTH secretion increasing.Drink and glucocorticoid secretion is increased, urine calcium increases, and intestinal calcium absorption reduces; Long-term alcohol person hypogonadism, as concurrent liver cirrhosis also will affect the generation of 25-(OH) D3; Therefore the osteoporotic cause of disease of alcoholic-toxic is the consequence of many-sided comprehensive function.
The factors such as the activity of old people reduces, sunshine lacks, gastrointestinal absorption function and reabsorption ability go down year by year, all may be formed with certain relation with osteoporotic.
3. inherited genetic factors stature, the girth of a garment, muscular degree are all relevant with heredity with gastrointestinal function.Easily there is osteoporosis in white people (Aisan also approximate white people), and osteoporosis not easily occurs for South Africa Bantu, Black people, and tall and thin stature person incidence of osteoporosis is more much higher than podge.
4. immune factor osteoclast derives from large mononuclear cell, has potential immunologic function.During immunologic function disorder, accelerated bone absorbs by all means, delays osteogenesis, causes.
Medication is treated: 1. should undertaking therapy reason be that osteon (the cylindrical bone unit of the diameter 0.2mm of cortical bone and bone trabecula) that is complete and partial disappearance can not regenerate as early as possible, but the osteon attenuated, can restore to the original state through treatment.Therefore, it is impossible for reversing the osteon (formation osteoporosis) disappeared, and early intervention can prevent the osteoporosis of most people.The climacteric (45 years old) of women just should start treatment.Male often can be slow 10 years.2. should not ignore the treatment that there is the specific cause of disease, the overlap especially should not ignoring primary osteoporosis and secondary osteoporosis exists.3. lenitive remedy measures answers the acute stage of choose reasonable vertebral compression fracture, and lenitive method has: analgesic, muscle relaxant, thermotherapy, massage and rest.Osteoporotic fracture or the caused misery of deformity, can be eased through the sports treatment of particular design, some patient can wear protective corset or back bracket.The motion of exercising abdominal muscles and dorsal muscles is useful for most patient.Analgesic has the possibility causing old people's gastrorrhagia.Therefore, indomethacin (indometacin) suppository (anus is filled in) and diclofenac emulsion agent (putting on the skin) is selected as far as possible outward.4. should pay attention to the effectiveness of Primary Care, safety, feasibility and economy, as motion, drink milk, get sun, careful fall prevention.5. the 3 large class medicines such as calcium preparation, vitamin D and bone resorption depressant, by whole world extensive use after FDA approval.For more serious case, necessity and the safety of these 3 kinds of medicine use in conjunction should not be ignored.Calcium preparation provides osteoplastic raw material, and vitamin D promotes the absorption of intestinal calcium and suppresses the loss of bone calcium, and bone resorption depressant can suppress the too fast bone resorption speed of post menopausal and senile osteoporosis.When triple combination applies, effect is coordinated mutually, likens to " aero-amphibious warfare ".6. should not comprise 4 classes such as estrogen, estrogenic agents, Diphosphonate, calcitonin by two or more bone resorption depressant bone resorption depressants of use in conjunction, usually apply separately or in turn; But combine 2 kinds or multiple, and during enough application (such as: while the estrogen of enough dose substitutes, the dosage of application Alendronate sodium (Fosamax) 10mg every day), although the increase of bone density is more effective, still do not understand the impact for " bone micro-structure ", " bone fragility ", " incidence of fracture ".
Chinese medical discrimination is divided into: 1, liver-kidney yin deficiency primary symptom: aching pain in waist and back, and soreness of the waist and knees is tired unable, dry pharynx dryness of the tongue, feverish sensation in the palms and soles, night sweat spontaneous perspiration, red tongue with thin fur, less or no fur light, and thready and rapid pulse.2, deficiency of yang of liver and kidney type primary symptom: back cold type of pain, soreness of the waist and knees, very then hunch, extremity are afraid of cold, clear urine in large amounts, and nocturia is frequent, and aversion to cold and preference for warmth, pale tongue with white fur, deep-thready pulse is dazzled.3, yang deficiency of spleen and stomache primary symptom: aching pain in waist and back, waist lower limb is heavy, limbs fatigue, joint aches, edema of lower limbs, lustreless complexion, dizzy, indigestion and loss of appetite, large loose stool, the fat greasy fur of light red tongue, deep-rolling pulse.4, cold coagulation BI-syndrome involved the blood vessels type primary symptom: lumbar and back pain, very then hunch, extremities joint is out of shape, limitation of activity, and extremity assemble paralysis, complexion darkness, and tongue is dim or dark red greasy in vain, deep and stringy pulse.
With regard to doctor trained in Western medicine, there are some side effect in Therapeutic Method, and medicine has certain damage to human body, and the traditional Chinese medical science is as taking from nature, and the method for biology etc., therefore also exists very large advantage in treatment.
Summary of the invention
Technical problem to be solved by this invention is, provides one and treats the osteoporotic medicine of liver-kidney yin deficiency, have effect of the liver and the kidney tonifying, benefiting qi and nourishing blood, strengthening the tendons and bones, benefiting QI for strengthening the superficies, enriching yin and nourishing kidney, cure mainly liver-kidney yin deficiency osteoporosis.The present invention utilizes Traditional Chinese medical theory, is particular about Overall View, by regulating whole body matrix, can improve sclerotin, recovers bone health, alleviating pain, improves loose symptom; Safe and effective, convenient drug administration, therapeutic effect is good, and instant effect not easily recurs, and has no side effect, and patient is easy to accept, and can carry out clinical market exploitation.
For solving the problems of the technologies described above, the invention provides one and treat the osteoporotic medicine of liver-kidney yin deficiency, wherein, described medicine comprises following raw medicinal material: Fructus Ilicis Purpureae, Hepar Sus domestica, Hepar Caprae seu ovis, Cornu Cervi, Fructus Lycii, Flos Caryophylli, Radix Dipsaci, Radix Achyranthis Bidentatae, Fructus Amomi, Semen Astragali Complanati, Fructus Mori, Semen Ziziphi Spinosae, Semen pini koraiensis, semen juglandis, Radix Codonopsis Convolvulaceae, Ganoderma, Succus Bambusae, Placenta Hominis, Carnis Arca inflata, Rhizoma Cibotii, Caulis Sacchari sinensis, Herba Eupatorii Heterophylli, Radix seu Caulis Parabarii, Herba Pyrolae, Radix Saposhnikoviae, Herba avenae fatuae, Radix Tylophorae arenicolae, Semen vignae sinensis, Rhizoma Polygonati Cirrhifolii, musk orchid, Carnis Trionycis.
Wherein, the weight portion Soviet Union of described raw medicinal material is than being: Fructus Ilicis Purpureae 15-20 weight portion, Hepar Sus domestica 7-13 weight portion, Hepar Caprae seu ovis 5-12 weight portion, Cornu Cervi 1-3 weight portion, Fructus Lycii 10-14 weight portion, Flos Caryophylli 15-20 weight portion, Radix Dipsaci 5-12 weight portion, Radix Achyranthis Bidentatae 8-14 weight portion, Fructus Amomi 10-20 weight portion, Semen Astragali Complanati 15-20 weight portion, Fructus Mori 15-20 weight portion, Semen Ziziphi Spinosae 10-20 weight portion, Semen pini koraiensis 15-25 weight portion, semen juglandis 15-20 weight portion, Radix Codonopsis Convolvulaceae 12-23 weight portion, Ganoderma 6-12 weight portion, Succus Bambusae 10-15 weight portion, Placenta Hominis 3-7 weight portion, Carnis Arca inflata 5-10 weight portion, Rhizoma Cibotii 7-11 weight portion, Caulis Sacchari sinensis 15-20 weight portion, Herba Eupatorii Heterophylli 10-20 weight portion, Radix seu Caulis Parabarii 8-13 weight portion, Herba Pyrolae 10-20 weight portion, Radix Saposhnikoviae 10-20 weight portion, Herba avenae fatuae 15-23 weight portion, Radix Tylophorae arenicolae 7-13 weight portion, Semen vignae sinensis 10-20 weight portion, Rhizoma Polygonati Cirrhifolii 2-5 weight portion, musk orchid 15-23 weight portion, Carnis Trionycis 6-13 weight portion.
Wherein, the ratio of weight and number of described raw medicinal material is: Fructus Ilicis Purpureae 18-20 weight portion, Hepar Sus domestica 7-10 weight portion, Hepar Caprae seu ovis 9-12 weight portion, Cornu Cervi 1-3 weight portion, Fructus Lycii 10-14 weight portion, Flos Caryophylli 15-20 weight portion, Radix Dipsaci 5-10 weight portion, Radix Achyranthis Bidentatae 8-10 weight portion, Fructus Amomi 15-20 weight portion, Semen Astragali Complanati 15-20 weight portion, Fructus Mori 15-20 weight portion, Semen Ziziphi Spinosae 15-20 weight portion, Semen pini koraiensis 15-20 weight portion, semen juglandis 15-20 weight portion, Radix Codonopsis Convolvulaceae 12-20 weight portion, Ganoderma 6-12 weight portion, Succus Bambusae 10-15 weight portion, Placenta Hominis 5-7 weight portion, Carnis Arca inflata 5-10 weight portion, Rhizoma Cibotii 7-11 weight portion, Caulis Sacchari sinensis 15-20 weight portion, Herba Eupatorii Heterophylli 15-20 weight portion, Radix seu Caulis Parabarii 10-13 weight portion, Herba Pyrolae 15-20 weight portion, Radix Saposhnikoviae 10-15 weight portion, Herba avenae fatuae 15-20 weight portion, Radix Tylophorae arenicolae 10-13 weight portion, Semen vignae sinensis 15-20 weight portion, Rhizoma Polygonati Cirrhifolii 2-5 weight portion, musk orchid 15-20 weight portion, Carnis Trionycis 6-10 weight portion.
Wherein, the ratio of weight and number of described raw medicinal material is: Fructus Ilicis Purpureae 16 weight portion, Hepar Sus domestica 8 weight portion, Hepar Caprae seu ovis 7 weight portion, Cornu Cervi 1 weight portion, Fructus Lycii 12 weight portion, Flos Caryophylli 16 weight portion, Radix Dipsaci 8 weight portion, Radix Achyranthis Bidentatae 10 weight portion, Fructus Amomi 12 weight portion, Semen Astragali Complanati 16 weight portion, Fructus Mori 16 weight portion, Semen Ziziphi Spinosae 15 weight portion, Semen pini koraiensis 16 weight portion, semen juglandis 16 weight portion, Radix Codonopsis Convolvulaceae 18 weight portion, Ganoderma 8 weight portion, Succus Bambusae 12 weight portion, Placenta Hominis 5 weight portion, Carnis Arca inflata 6 weight portion, Rhizoma Cibotii 8 weight portion, Caulis Sacchari sinensis 16 weight portion, Herba Eupatorii Heterophylli 18 weight portion, Radix seu Caulis Parabarii 9 weight portion, Herba Pyrolae 15 weight portion, Radix Saposhnikoviae 16 weight portion, Herba avenae fatuae 18 weight portion, Radix Tylophorae arenicolae 9 weight portion, Semen vignae sinensis 15 weight portion, Rhizoma Polygonati Cirrhifolii 3 weight portion, musk orchid 18 weight portion, Carnis Trionycis 8 weight portion.
Wherein, the ratio of weight and number of described raw medicinal material is: Fructus Ilicis Purpureae 19 weight portion, Hepar Sus domestica 8 weight portion, Hepar Caprae seu ovis 10 weight portion, Cornu Cervi 2 weight portion, Fructus Lycii 12 weight portion, Flos Caryophylli 18 weight portion, Radix Dipsaci 8 weight portion, Radix Achyranthis Bidentatae 9 weight portion, Fructus Amomi 18 weight portion, Semen Astragali Complanati 18 weight portion, Fructus Mori 17 weight portion, Semen Ziziphi Spinosae 16 weight portion, Semen pini koraiensis 17 weight portion, semen juglandis 16 weight portion, Radix Codonopsis Convolvulaceae 15 weight portion, Ganoderma 8 weight portion, Succus Bambusae 12 weight portion, Placenta Hominis 6 weight portion, Carnis Arca inflata 6 weight portion, Rhizoma Cibotii 8 weight portion, Caulis Sacchari sinensis 16 weight portion, Herba Eupatorii Heterophylli 16 weight portion, Radix seu Caulis Parabarii 12 weight portion, Herba Pyrolae 17 weight portion, Radix Saposhnikoviae 12 weight portion, Herba avenae fatuae 16 weight portion, Radix Tylophorae arenicolae 12 weight portion, Semen vignae sinensis 16 weight portion, Rhizoma Polygonati Cirrhifolii 3 weight portion, musk orchid 16 weight portion, Carnis Trionycis 8 weight portion.
In order to solve the problem, present invention also offers a kind of preparation method of described medicine, wherein, the dosage form of described medicine is decoction, and its preparation method comprises the following steps:
Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 2-5cm, soak 3-8 hour;
Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 200-300ml, filters, obtain filtrate a, for subsequent use;
Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 4-10 hour;
Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 45-55 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.
Wherein, the dosage form of described medicine is granule, and its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 3 ~ 7 times, mixture is the ethanol of 80% ~ 90%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.14 ~ 1.20, spraying dry, the inlet temperature 160 ~ 170 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.1 ~ 0.3 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
Wherein, the dosage form of described medicine is capsule, and its preparation method comprises the following steps:
The first step, Fructus Ilicis Purpureae, Hepar Sus domestica, Hepar Caprae seu ovis, Cornu Cervi and Fructus Lycii are mixed in described ratio, add the water extraction volatile oil relative to 3 ~ 5 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 1 ~ 3, stirs 60 minutes ~ 90 minutes, temperature 40 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.12 ~ 1.15;
Second step, Radix Achyranthis Bidentatae, Fructus Amomi, Semen Astragali Complanati, Fructus Mori and Semen Ziziphi Spinosae are mixed in described ratio, add relative to mixture 5 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter respectively, each time filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.10 ~ 1.12, for subsequent use;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 3 ~ 5 hours, filter, and when being concentrated into 60 DEG C, relative density is the clear paste of 1.18 ~ 1.20;
4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 2 ~ 5 weight portion carboxymethyl starch sodium, 3 ~ 30 weight starch mix homogeneously, adding 100 ~ 150 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 1 ~ 3 weight portion magnesium stearate, then loads in gelatine capsule.
Wherein, the pharmaceutical dosage form of described Chinese medicine composition can also be: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster, syrup, powder or patch.
The invention has the beneficial effects as follows: the present invention has effect of the liver and the kidney tonifying, benefiting qi and nourishing blood, strengthening the tendons and bones, benefiting QI for strengthening the superficies, enriching yin and nourishing kidney, cure mainly liver-kidney yin deficiency osteoporosis.The present invention utilizes Traditional Chinese medical theory, is particular about Overall View, by regulating whole body matrix, can improve sclerotin, recovers bone health, alleviating pain, improves loose symptom; Safe and effective, convenient drug administration, therapeutic effect is good, and instant effect not easily recurs, and has no side effect, and patient is easy to accept, and can carry out clinical market exploitation.
Detailed description of the invention
The present invention treats effect that liver-kidney yin deficiency osteoporosis has the liver and the kidney tonifying, benefiting qi and nourishing blood, strengthening the tendons and bones, benefiting QI for strengthening the superficies, enriching yin and nourishing kidney, selects prescription: Fructus Ilicis Purpureae, Hepar Sus domestica, Hepar Caprae seu ovis, Cornu Cervi, Fructus Lycii, Flos Caryophylli, Radix Dipsaci, Radix Achyranthis Bidentatae, Fructus Amomi, Semen Astragali Complanati, Fructus Mori, Semen Ziziphi Spinosae, Semen pini koraiensis, semen juglandis, Radix Codonopsis Convolvulaceae, Ganoderma, Succus Bambusae, Placenta Hominis, Carnis Arca inflata, Rhizoma Cibotii, Caulis Sacchari sinensis, Herba Eupatorii Heterophylli, Radix seu Caulis Parabarii, Herba Pyrolae, Radix Saposhnikoviae, Herba avenae fatuae, Radix Tylophorae arenicolae, Semen vignae sinensis, Rhizoma Polygonati Cirrhifolii, musk orchid, Carnis Trionycis.
Wherein, Fructus Ilicis Purpureae, Hepar Sus domestica, Hepar Caprae seu ovis, Cornu Cervi, Fructus Lycii, Flos Caryophylli, Radix Dipsaci, Radix Achyranthis Bidentatae, Fructus Amomi, Semen Astragali Complanati, Fructus Mori, Semen Ziziphi Spinosae the liver and the kidney tonifying; Semen pini koraiensis, semen juglandis, Radix Codonopsis Convolvulaceae, Ganoderma, Succus Bambusae, Placenta Hominis, Carnis Arca inflata, Rhizoma Cibotii, Caulis Sacchari sinensis, benefiting qi and nourishing blood; Herba Eupatorii Heterophylli, Radix seu Caulis Parabarii, Herba Pyrolae strengthening the tendons and bones: Radix Saposhnikoviae, Herba avenae fatuae benefiting QI for strengthening the superficies; Radix Tylophorae arenicolae, Semen vignae sinensis, Rhizoma Polygonati Cirrhifolii, musk orchid, Carnis Trionycis enriching yin and nourishing kidney.Ingredients scientific compatibility, function, reaches the object for the treatment of.
Now the pharmacology situation of each taste raw medicinal material is described below:
Fructus Ilicis Purpureae: [nature and flavor] " detailed outline ": " sweetness and bitterness, cool, nontoxic." [returning through] 1. " book on Chinese herbal medicine converge speech ": " enters meridian of Foot-JUE YIN." 2. " book on Chinese herbal medicine is looked for the truth ": " enters liver, kidney." [function cures mainly] removes wind.Tonify deficiency.Dispelling the wind and dampness pathogens arthralgia pain, hemorrhoid.1. " Bencao Tujing ": " infusing drugs in wine goes wind to enrich blood." 2. " book on Chinese herbal medicine is looked for the truth ": " strong muscle of tonifying liver, reinforcing the kidney to strengthen the bone." 3. " Jiangsu medical material will ": " dispelling the wind and dampness pathogens arthralgia pain."
Hepar Sus domestica: [nature and flavor] sweetness and bitterness, temperature.1. " a thousand pieces of gold dietetic therapy "; " bitter, flat, nontoxic." 2. " Bencao Tujing ": " temperature." 3. " occupying diet spectrum with breath ": " sweetness and bitterness, temperature." [return through] " detailed outline ": " enters liver." [function cures mainly] tonifying liver, nourishes blood, improving eyesight.Control blood deficiency and yellow complexion, nyctalopia, conjunctival congestion, edema, beriberi.1. " a thousand pieces of gold dietetic therapy ": " main improving eyesight." 2. supplement to the Herbal: " main beriberi.Hollow, cut and give birth to, enter it with Rhizoma Zingiberis Recens vinegar, let out when micro-.If first dysentery, does not namely take." 3. " dietitian's heart mirror ": " flatulence of harnessing the river is full, edema." 4. " herbal classic is met former ": " controls proctoptosis." 5. " book on Chinese herbal medicine is new again ": " treating the liver wind."
Hepar Caprae seu ovis: nature and flavor sweetness and bitterness is cool.1. Tang Materia Medica: " property is cold." 2. " detailed outline ": " is bitter, cold, nontoxic." 3. " occupying diet promise with breath ": " is sweet, cool." [return through] " former machine opens micro-": " enters Liver Channel." [function cures mainly] beneficial blood, tonifying liver, tomorrow.Control blood deficiency and yellow complexion weakness and emaciation, hepatasthenia dim eyesight is dim-sighted, nyctalopia, and optic atrohic blindness is hidden from view.1. " property of medicine opinion ": " improving eyesight of QINGYANG liver clothes." 2. " a thousand pieces of gold dietetic therapy ": " tonifying liver, improving eyesight." 3. Tang Materia Medica: " treats liver-wind deficiency-heat.Conjunctival congestion is dark without finding, eats sub-liver seven pieces raw." 4. " modern Practical Chinese medicinal ": " is applicable to chlorosis, married woman's postpartum anemia, pulmonary tuberculosis, the oculopathy (eye disorder due to malnutrition in children, nyctalopia etc.) of the weak and disorderly A shortage of supporting one's family of children's."
Cornu Cervi: nature and flavor are salty, temperature.1. " herbal classic ": " temperature." 2. " not Lu ": " salty in the mouth, tepor, nontoxic." [return through] enters liver, kidney channel.1. " book on Chinese herbal medicine must be joined ": " few sun of starting with, meridian of Foot-SHAO YIN blood system." 2. " key medicine divides agent ": " enters kidney channel, double enter the heart, liver two warp." [function cures mainly] promoting the circulation of blood, detumescence, kidney tonifying.Control sore swollen toxin, blood stasis is had a pain, asthenia internal injury, lumbar vertebrae pain.1. " herbal classic ": " main malignant boil carbuncle, by evil gas, stagnant blood is in the moon." 2. " not Lu ": " except lower abdomen blood shoot, pain along the spinal column, injured stagnant blood, QI invigorating." 3. " a thousand pieces of gold dietetic therapy ": " bits take tool for weighing medicine in ancient China, day three, physical strength profiting, bone strengthening marrow, mend and hinder absolutely." 4. the Meng numerous: " married woman's sexual intercourse in dream person, Cornu Cervi end a dose of powder just as much as the amount can be taken up with three fingers, and rice wine clothes; In uterus, remaining blood is not to the utmost for the dead, takes tool for weighing medicine in ancient China with rice wine and Cornu Cervi ash, night one day three." 5. " Japan hanako materia medica ": " is treated and is suffered from carbuncle sore and to swell pyretic toxicity etc., and vinegar rubs deposited; De-smart hematuria, water rubs clothes; Children's's congenital deformity of the tongue thrush, processs and presses it."
Fructus Lycii: [nature and flavor] are sweet is flat.[return through] returns liver, kidney channel.[function cures mainly] nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.
Flos Caryophylli: [nature and flavor] are pungent, temperature.[return through] returns spleen, stomach, lung, kidney channel.[function cures mainly] warming middle-JIAO to send down the adverse QI, reinforcing the kidney and supporting YANG.For Deficiency and coldness of spleen and stomach, singultus is vomitted, lack of appetite and vomiting, trusted subordinate's cold type of pain, impotence due to deficiency of the kidney.
Radix Dipsaci: [nature and flavor] are bitter, pungent, tepor.[return through] returns liver, kidney channel.[function cures mainly] invigorating the liver and kidney, bone and muscle strengthening, continuous injured, only metrorrhagia.For soreness of the waist and knees, rheumatic arthralgia, metrorrhagia, vaginal bleeding during pregnancy, injury from falling down.Prepared RADIX DIPSACI with yellow rice wine is used for rheumatic arthralgia, injury from falling down.Prepared RADIX DIPSACI with salt solution is used for soreness of the waist and knees.
Radix Achyranthis Bidentatae: [nature and flavor] are bitter, sour is flat.[return through] returns liver, kidney channel.[function cures mainly] invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.For soreness of waist and knee joint, muscles and bones is unable, amenorrhea lump in the abdomen, dizziness due to hyperactivity of liver-YANG.
Fructus Amomi: [nature and flavor] are pungent, temperature.[return through] returns spleen, stomach, kidney channel.[function cures mainly] removing dampness is whetted the appetite, warming spleen and stopping diarrha, regulates the flow of vital energy antiabortive.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.
Semen Astragali Complanati: [nature and flavor] are sweet, temperature.[return through] returns liver, kidney channel.[function cures mainly] temperature compensation Liver and kidney, controlling nocturnal emission with astringent drugs, reducing urination, improving eyesight.For lumbago due to renal deficiency, seminal emission premature ejaculation, nebulousurine leukorrhagia, dribbling urination, dizzy blurred vision.
Fructus Mori: [nature and flavor] are sweet, cold.1. Tang Materia Medica: " sweet in the mouth, cold, nontoxic." 2. amplification on Canon of Materia Medica: " is micro-cool." 3. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " sweet acid." [return through] enters liver, kidney channel.1. " Bencao Congxin ": " enter kidney." 2. " book on Chinese herbal medicine brief points ": " enters sufficient faint the moon, shaoyin channel." [function cures mainly] tonifying liver, kidney tonifying, relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and grows liquid.Control hepatic and renal YIN deficiency, quench one's thirst, constipation, order is dark, tinnitus, scrofula, articular instability.1. Tang Materia Medica: " single food, master quenches one's thirst." 2. supplement to the Herbal: " sharp the five internal organs joint, logical vim and vigour, smash end, honey and be ball.It is thirsty that " 3. amplification on Canon of Materia Medica: " controls heat, spermatogenesis god, and small intestinal heat.Dirty and the controlling nocturnal emission with astringent drugs of " 4. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " kidney tonifying, takes hair color improving eyesight for a long time." 5. " detailed outline ": " smashes juice drink, separates alcohol intoxication, wine brewing clothes, diuretic gas, detumescence." 6. " beautiful Chinese catalpa medicine solution ": " controls infirmity pouring, scrofula, tinea alba." 7. " book on Chinese herbal medicine is looked for the truth ": " heat extraction, yin nourishing, antidiarrheal." 8. " occupying diet spectrum with breath ": " nourish liver and kidney, enrich blood, wind-damp dispelling, walks with vigorous strides to carry out, breath wind syndrome caused by deficiency, clear asthenic fire." 9. " modern Practical Chinese medicinal ": " refrigerant cough-relieving." 10. " Chinese medicine shape sex experience differential method ": " is antiabortive."
Semen Ziziphi Spinosae: [nature and flavor] are sweet is flat.1. " herbal classic ": " sour in the mouth is flat." 2. " not Lu ": " be nontoxic." 3. amplification on Canon of Materia Medica: " tepor." 4. principle of Correct Diet: " sour in the mouth is sweet, flat." [return through] enters the heart, spleen, liver, gallbladder meridian.1. " detailed outline ": " sufficient the moon of fainting, few sun." 2. " Thunder God concocts property of medicine solution ": " enters the heart, spleen, liver, gallbladder four warp." [function cures mainly] nourishing the liver, mind calming, calms the nerves, arresting sweating.Control restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility.1. " herbal classic ": " main trusted subordinate's cold and heat, pathogens agglomerating gas gathers, painful limbs, arthralgia chiefly caused by damp pathogen." 2. " not Lu ": " main vexatious insomnia, umbilicus is pain up and down, and blood turns chronic diarrhea, sweating due to debility excessive thirst, invigorating middle warmer, the liver benefiting gas, and hard muscles and bones helps cloudy gas, makes us fertile strong." 3. " property of medicine opinion ": " main muscles and bones wind, fries end and takes it as soup." 4. supplement to the Herbal: " sleeps, and how life makes, and must not sleep and fry." 5. Wang Haogu: " controls milk-livered sleeplessness, trembles with fear also, fries clothes; Control somnolence due to gallbladder-excess, heat also, use by life." 6. " book on Chinese herbal medicine converges and says ": " astringing QI is calmed the nerves, and flourish muscle supports marrow, stomach function regulating activating the spleen." 7. " book on Chinese herbal medicine is new again ": " suppressing the hyperactive liver is regulated the flow of vital energy, and nourishing lung-YIN, warming middle-JIAO dampness removing, astringing QI hidroschesis, beneficial will is breathed out surely, hearing-improing and eyesight improving."
Semen pini koraiensis: [nature and flavor] are sweet, temperature.1. " Haiyao Bencao, Oversea Materia Medica ": " sweet in the mouth, temperature, nontoxic greatly." 2. " Kaibao Bencao ": " sweet in the mouth, little temperature, nontoxic." 3. " beautiful Chinese catalpa medicine solution ": " sweet in the mouth is pungent, and gas is put down." [return through] enters liver, lung, large intestine channel.1. " beautiful Chinese catalpa medicine solution ": " enter spleen of Foot-Taiyin, the bright large intestine of hands sun, the few cloudy heart of hands, liver channel of foot-Jueyin." 2. " key medicine divides agent ": " enters lung, large intestine channel." [function cures mainly] nutrient solution, relieves dizziness, high fever, infantile convulsions, epilepsy, etc., lung moistening, and laxation, controls migratory arthralgia, dizziness, cough caused by dryness, spits blood, constipation.1. " Haiyao Bencao, Oversea Materia Medica ": " main all wind, warming intestines and stomach." 2. " Japan hanako materia medica ": ", by migratory arthralgia cold, weakness with emaciation weak breath, tonifying for the deficiency, moistens skin, fertile the five internal organs." 3. " Kaibao Bencao ": " main joint wind, dizziness, removes dead flesh, bleaches, aproll gas, and moistening five ZANG-organs is not hungry." 4. amplification on Canon of Materia Medica: " and Semen Platycladi are ruled together constipation due to insufficiency." 5. " detailed outline ": " lung moistening, controls dryness accumulated in the stomach and intestine cough." 6. " explaining abstruseness of the canon of materia medica ": " lung benefiting antitussive, benefiting qi and nourishing blood, intestine moistening is quenched the thirst, and warming middle-JIAO searches wind." 7. " book on Chinese herbal medicine is new again ": " lung moistening spleen invigorating, holds back cough, emesis blood."
Semen juglandis: [nature and flavor] are sweet, temperature.1. " seven volume cuisine canons ": " sweet in the mouth, temperature." 2. " Bencao Tujing ": " is hot in nature." 3. " medical center bun is wanted ": " is sweet and micro-pungent, and gross weight is puckery." [return through] enters kidney, lung meridian.1. " detailed outline ": " enter kidney, lung." 2. " Thunder God concocts property of medicine solution ": " enters lung, liver, kidney three warp." 3. " book on Chinese herbal medicine is looked for the truth ": " enters the gate of vitality, double enter lung, large intestine." 4. " book on Chinese herbal medicine brief points ": " enters bright, the meridian of Hand-TAI YIN of foot sun." intestine moistening, controlling suffers from a deficiency of the kidney breathes heavily and coughs, lumbago flaccidity of the lower limbs, sexual impotence, seminal emission, frequent micturition, stranguria caused by urinary stone, constipation due to dry stool for [function cures mainly] tonifying the kidney to consolidate the essence, warming the lung Dingchuan.1. the Meng numerous: " black beard and hair, informal dress kindred is fine and smooth smooth for qualcomm meridian, profit blood vessels." 2. Cui Yu stannum " cuisine canon ": " therapeutic method to keep the adverse QI flowing downwards, main sore throat, kills tapeworm.Making us of " 3. supplement to the Herbal: " food is fertile strong." 4. " Kaibao Bencao ": " polyphagia diuresis, goes five hemorrhoid." 5. " seven volume cuisine canons ": " removes pneumatosis." 6. " detailed outline ": " benefiting qi and nourishing blood, moistening the lung and resolving the phlegm, the beneficial gate of vitality, profit three is burnt, warming the lung intestine moistening.Control deficiency and coldness to breathe heavily and cough, the heavy pain of waist foot, trusted subordinate's colic, dysentery hemorrhoidal hamorrhage, loose toxic swelling, sends out variola, and copper processed is malicious." 7. " medical center bun is wanted ": " the kidney invigorating, the profit gate of vitality, controlling nocturnal emission with astringent drugs, profit large intestine, logical functional constipation, only diarrhea due to cold pathogen diarrhea of deficiency type." 8. " Bencao Congxin ": " controls flaccidity, reinforcing YIN-essence."
Radix Codonopsis Convolvulaceae: sweet, the micro-hardship of nature and flavor, puckery, micro-cool.[function cures mainly] invigorating QI and blood, spleen invigorating, replenishing body fluid and clearing away heat pathogen.For flu, cough, tonsillitis, chest pain, inappetence, malnutrition.
Ganoderma: [nature and flavor] are sweet; Flat; Nontoxic.[return through] lung; The heart; Spleen; Kidney channel.[function cures mainly] replenishing QI and blood; Tranquilizing mind; Strengthening the spleen and stomach.Main asthenia; Cardiopalmus; Insomnia; Dizzy; Spiritlessness and weakness; Chronic cough is panted; Coronary heart disease; Silicosis; Tumor.
Succus Bambusae: [nature and flavor] sweetness and bitterness, cold.1. " not Lu ": " Great Cold." 2. " detailed outline ": " is sweet, Great Cold, nontoxic." 3. " medicineization justice ": " slightly sweet flavor, cool in nature." 4. " Bencao Congxin ": " sweetness and bitterness, cold, sliding." [return through] enters the heart, stomach warp, 1. " medicineization justice ": " enter lung, stomach two warp." 2. " book on Chinese herbal medicine is new again ": " enters the heart, liver, lung three warp." the sliding expectorant of [function cures mainly] heat clearing away, relieving convulsion sharp key.Control middle wind-phlegm fan, lung-heat expectorant is stopped up, infantile convulsion, epilepsy, high fever excessive thirst, restlessness during pregnancy, tetanus.1. " not Lu ": " treat sudden and violent apoplexy migratory arthralgia, in the heart large heat, only unhappy (have under " detailed outline " last sentence ' recurrence caused by overexertion of quenching one's thirst ')." 2. " property of medicine opinion ": " controls apoplexy aphonia in silence." 3. supplement to the Herbal: " is yearningly vexed for a long time." 4. " detailed outline ": " controls eclampsia gravidarum puerperal tetanus, separates Extract Aconiti Radicis sucus poison." 5. essentials of Matea Medica: " pathogenic wind expelling pathogenic fire reducing, moisturize row expectorant, nourish blood tonifying YIN, sharp key tomorrow.Control apoplexy locked mouth, the large heat of expectorant fan, puerperal tetanus is demented, and unhappiness is quenched one's thirst, spontaneous sweating due to deficientcy of blood." 6. " book on Chinese herbal medicine is new again ": " clearing away heart-fire, fall liver-fire, reduce phlegm and quench the thirst, antipyretic relieving restlessness, controls toothache, bright eyes."
Placenta Hominis: nature and flavor are sweet, salty, temperature.[return through] GUIXIN, lung, kidney channel.[function cures mainly] the kidney warming mends essence, benefiting QI and nourishing blood.For asthenia weakness and emaciation, hectic fever due to YIN-deficiency night sweat, cough and asthma, lack of appetite is breathed hard, impotence and seminal emission, infertile hypogalactia.
Carnis Arca inflata: [nature and flavor] are sweet, temperature.1. " not Lu ": " hide sweet, flat, nontoxic." 2. " food furuncle book on Chinese herbal medicine ": " is cold." 3. " product remittance essence is wanted ": " salty in the mouth, warm in nature, nontoxic." [function cures mainly] enriches blood, warming middle-JIAO, stomach invigorating.Control blood deficiency scabies numbness, stomachache, dyspepsia, dysentery pus and blood.1. " not Lu ": " main scabies numbness lets out dysentery, passing stool with blood and pus." 2. " Treatise on Dietetic Therapy ": " moistening five ZANG-organs, controls and quenches one's thirst, joint." 3. supplement to the Herbal: " controls trusted subordinate's cold air, spinal column cold wind, sharp the five internal organs, stomach invigorating." 4. " four tones of standard Chinese pronunciation book on Chinese herbal medicine ": " warming middle-JIAO helps digestion, and plays sun." 5. " Japan hanako materia medica ": " beneficial color." 6. " medical center bun is wanted ": " reinforcing the heart blood, dissipating blood stasis blood, relieving restlessness relieving alcoholic intoxication, the expectorant of broken knot."
Rhizoma Cibotii: property bitter but sweet flavor, temperature.1. " herbal classic ": " bitter in the mouth is flat." 2. " WU Pu Bencao ": " paulownia monarch, Yellow Emperor, a legendary ruler, qi primary, Thunder God, Bian Que: sweet, nontoxic.Li Shi: temperature." 3. " property of medicine opinion "; " bitter in the mouth is pungent, slight fever." [return through] enters liver, kidney channel.1. " Thunder God concocts property of medicine solution ": " enter kidney, bladder two warp." 2. " book on Chinese herbal medicine is looked for the truth ": " enters liver, kidney." 3. " book on Chinese herbal medicine is new again ": " enters the heart, liver, kidney three warp." [function cures mainly] invigorating the liver and kidney, except rheumatism, strong waist foot, sharp joint.Control back ache, gonalgia flaccidity of the lower limbs, cold-damp general arthralgia, lose and drown, frequent micturition, seminal emission, leucorrhea.1. " herbal classic ": " main back is strong, machine-operated emergency, general arthralgia cold-damp, gonalgia.Quite sharp old man." 2. " not Lu ": " treats that losing drowns does not save, and man's flaccidity of the lower limbs lumbago, ailment said due to cold or exposure drenches dew, weak breath order Dark, hard ridge, sharp pitching, woman's damaging the spleen and stomach, and joint is heavy." 3. " property of medicine opinion ": " controls man woman poison wind weak foot, and pathogen arthralgia chiefly caused by damp pathogen, kidney qi is weak, tonification man, stricture of vagina muscles and bones." 4. " detailed outline ": " strong Liver and kidney, strong bone, controls wind void." 5. " beautiful Chinese catalpa medicine solution ": " lets out wet cold removing, plays flaccidity pain relieving, lets out kidney liver dampness, consciousness restoring, bone and muscle strengthening, controls lumbago knee joint pain, and the swollen lower limb of foot is weak, seminal emission foul leukorrhea." 6. " detailed outline is picked up any lost article from the road ": " golden Rhizoma Cibotii only all skin ulcer blood goes out, and control insensitive impediment, black person parasite killing is more imitated." 7. " book on Chinese herbal medicine is new again ": " hard kidney nourishes blood, QI invigorating." 8. " Nanning City's medicine will ": " controls lumbago due to trauma."
Caulis Sacchari sinensis: [nature and flavor] are sweet, cold.1. " not Lu ": " sweet, flat, nontoxic." 2. " Japan hanako materia medica ": " is cold." 3. " this sketch of the southern regions of the Yunnan Province is said ": " abnormal smells from the patient is sweet, and cold nature is nontoxic." 4. " detailed outline ": " is sweet puckery, flat, nontoxic." [return through] enters lung, stomach warp.1. " Bencao Jingshu ": " start with, foot lunar, Foot yangming Channel." 2. " book on Chinese herbal medicine is newly organized ": " enters spleen, lung, intestine and small intestine." 3. " book on Chinese herbal medicine is new again ": " enters liver, spleen two warp." [function cures mainly] disappears heat, and promote the production of body fluid, the therapeutic method to keep the adverse QI flowing downwards, moisturizes.Control calentura Tianjin wound, restlessness and thirst, regurgitation is vomitted, xeropulmonary cough, constipation due to dry stool.And alcoholic intoxication.1. " not Lu ": " the main therapeutic method to keep the adverse QI flowing downwards and in, help taste, sharp large intestine." 2. " Treatise on Dietetic Therapy ": " main QI invigorating, the therapeutic method to keep the adverse QI flowing downwards of holding concurrently." 3. " Japan hanako materia medica ": " sharp intestine and small intestine, lower diarrhea due to disorder of qi, spleen reinforcing, expectorant is quenched the thirst, except vexed heat." 4. " daily book on Chinese herbal medicine ": " be deficiency-heat excessive thirst only, alcoholic intoxication." 5. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " controls hundred malicious all skin ulcers, carbuncle carbuncle on the back, mash deposited it; Juice: control mental derangement, deeply perturbed, apoplectic aphasia, washes open under water.Endure again treacle food, stomach function regulating is better." 6. " this sketch of the southern regions of the Yunnan Province is said ": ", with Sucus Zingberis clothes, can separate tetrodotoxin, TTX." 7. " book on Chinese herbal medicine is new again ": " and in relieve inflammation or internal heat, suppressing the hyperactive liver spleen invigorating, promoting the production of body fluid to quench thirst, controls vomitings and diarrhoea, malaria, dysentery, separates the fiery all poison of skin ulcer." 8. " occupying diet spectrum with breath ": " throat, bone and muscle strengthening, endogenous wind stopping nourishes blood, large tonifying spleen-yin."
Radix Tylophorae arenicolae: [nature and flavor] are pungent is flat.1. " vegetation is side just ": " pungent, temperature." 2. " Shaanxi Chinese herbal medicine ": " sweet in the mouth is micro-pungent, and property is put down." [function cures mainly] the kidney invigorating, spleen invigorating, removing toxic substances.Control chronic consumptive disease chronic cough, edema, leucorrhea, menoxenia, scrofula, skin ulcer scabies.1. " vegetation is side just ": " tonification reinforcing YIN-essence, removing toxic substances.The labor that cures the wound chronic cough, edema due to deficiency, infections labor, Serpentis, worm, mad dog wound." 2. " classifying herbal ": " pastes son of itching, loose poison, and logical hernia, only nose bleeding, control woman leucorrhea dizzy, is coated with scabies." 3. " conventional glossary of Herbs and Drugs among the people ": " relieves the pain, and detoxification, controls scrofula, stimulating milk secretion, cough-relieving." 4. " Shaanxi Chinese herbal medicine ": " enriching yin and nourishing kidney, invigorating the spleen and benefiting QI, regulating menstruation and activating blood.Control menoxenia, deficiency of YIN leucorrhea."
Semen vignae sinensis: [nature and flavor] are sweet is flat.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " taste is put down." 2. " detailed outline ": " is sweet salty, flat, nontoxic." 3. " Bencao Congxin ": " is sweet puckery, flat." [return through] enters spleen, kidney channel.1. " book on Chinese herbal medicine must be joined ": " enter meridian of Foot-TAI YIN edema caused by disorder of QI." 2. " book on Chinese herbal medicine is looked for the truth ": " enters kidney, double enter stomach." [function cures mainly] strengthening spleen, tonifying kidney.Control weakness of the spleen and stomach, dysentery, tell inverse, quench one's thirst, seminal emission, leucorrhea, nebulousurine, frequent micturition.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control spleen soil weak, appetite promoting and the spleen strengthening.QI invigorating in " 2. " detailed outline ": " reason, tonifying kidney and promoting digestion, and the five internal organs, adjust battalion to defend, spermatogenesis marrow.Only quench one's thirst, tell inverse, let out dysentery, frequent micturition, separate the big poison of Mus." 3. " Bencao Congxin ": " loose blood detumescence, heat-clearing and toxic substances removing." 4. " medical center bun is wanted ": " reinforcing the heart rushes down kidney, infiltration, diuresis, the turbid descending the lucid yang sending up." 5. " Traditional Chinese Medicine in Sichuan will ": " enriching yin and nourishing kidney, strengthening the spleen and stomach, helps digestion.Control dyspeptic abdominal distention, leucorrhea, nebulousurine and emission due to deficiency of the kidney."
Rhizoma Polygonati Cirrhifolii: [nature and flavor] Gan Xin is flat.1. " Shaanxi Chinese herbal medicine ": " sweet in the mouth is micro-pungent, warm in nature, slightly poisonous." 2. " Ningxia Chinese herbal medicine handbook ": " is pungent, flat." 3. " Chinese herbal medicine is commonly used in Tibet ": " property is put down, sweet in the mouth." [function cures mainly] nourishing lung-YIN, invigorating the spleen and benefiting QI, hemostasis of eliminating the phlegm, subduing swelling and detoxicating.Control chronic consumptive disease cough, dizzy, lack of appetite, seminal emission, night sweat, bleeding not during menses, puerperal, body lost, and spitted blood, epistaxis, traumatic hemorrhage, laryngopharynx swelling and pain, and skin ulcer swells, scrofula.1. " Shaanxi Chinese herbal medicine ": " spleen reinforcing lung moistening, enriching yin and nourishing kidney, promoting flow of QI and blood, astringing to arrest bleeding, sterilization of drawing out pus by applying a plaster to the affected part.Control insufficiency of the spleen few food, cough due to deficiency of the lung, dizzy bodily pain, seminal emission night sweat, metrorrhagia leucorrhea, furuncle is from the beginning of, scrofula." 2. " Ningxia Chinese herbal medicine handbook ": " hemostasis of eliminating the phlegm, subduing swelling and detoxicating.Control cough to spit blood, epistaxis, traumatic hemorrhage, laryngopharynx swelling and pain, sore swollen toxin." 3. " Chinese herbal medicine is commonly used in Tibet ": " strengthens the spleen and stomach, the lung moistening and production of body fluid promoting.Control all empty not enough, chronic consumptive disease is coughed, and muscles and bones flaccidity is soft." 4. Nanchuan " conventional Chinese herbal medicine handbook ": " the kidney invigorating lung benefiting, benefiting qi and nourishing yin.Deficient qi and blood after managing property."
Musk orchid: nature and flavor are sweet, temperature.[function cures mainly] enriching yin and nourishing kidney, nourishing the stomach, regulating menstruation.For neurasthenia, dizzy insomnia, irritated thirsty inappetence, early whitening of beard and hair, menoxenia.
Carnis Trionycis: [nature and flavor] are sweet is flat.1. " not Lu ": " sweet in the mouth." 2. " a thousand pieces of gold dietetic therapy ": " sweet in the mouth is flat, nontoxic." 3. " Bencao Tujing ": " property is cold." [return through] " book on Chinese herbal medicine is looked for the truth ": " enters liver." [function cures mainly] phencyclidine.Control hectic fever due to YIN-deficiency consumptive fever, chronic malaria, chronic dysentery, bleeding not during menses, scrofula.1. " not Lu ": " main damaging the spleen and stomach QI invigorating, tonifying for the deficiency." 2. " a thousand pieces of gold dietetic therapy ": " treats beriberi." 3. the Meng numerous: " housewife people is leaked down weakness and emaciation." 4. supplement to the Herbal: " main steam arthralgia chiefly caused by damp pathogen, swashs heat in abdomen.The five tastes cook it.Let out when micro-.During " 5. " Japan hanako materia medica ": " QI invigorating is adjusted, married woman's leukorrhagia, controls abdominal mass due to blood stasis lumbago." 6. " Bencao Tujing ": " tonify deficiency, heat of dehematizing." 7. " daily book on Chinese herbal medicine ": " mends impairment caused by overstrain, tonifying YANG gas, the deficiency of large nourishing YIN." 8. " detailed outline ": " Zuo Meat-broth eats, and controls chronic dysentery; Make ball clothes, control asthenia, mass beside the umbilicus, beriberi." 9. essentials of Matea Medica: " removing heat from blood nourishing YIN, also treating malaria, dysentery.The moon of " 10. " occupying diet spectrum with breath ": " nourish liver and kidney, the heat of clear asthenia.Main proctoptosis, metrorrhagia and leukorrhagia, scrofula ， mass in the abdomen."
Herba Eupatorii Heterophylli: [nature and flavor] acrid in the mouth, hardship, warm in nature.[return through] Liver Channel.[function cures mainly] promoting blood circulation and stopping pain, expelling wind and removing dampness, strengthening the tendons and bones, removing toxic substances.Main amenorrhea; Lump in the abdomen; Traumatic injury; Orchitis; Venom.
Radix seu Caulis Parabarii: nature and flavor are pained; Tepor.[return through] liver; Kidney channel.[function cures mainly] strengthening the tendons and bones.Main rheumatic ostalgia; Waist and leg ache.
Herba Pyrolae: [nature and flavor] sweetness and bitterness, temperature.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " warm in nature flat, acrid in the mouth." 2. " Shaanxi Chinese herbal medicine ": " is pained, flat." 3. " Shanxi Chinese herbal medicine ": " is sweet, temperature." [return through] " Zhiwu Mingshi Tukao ": " enters liver, kidney two warp." expelling wind and removing dampness, promoting blood flow to regulate menstruation, controls weak cough, over-strained hemoptysis, rheumatic arthritis, metrorrhagia, leucorrhea, traumatic hemorrhage for [function cures mainly] tonify deficiency, kidney tonifying.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control the disease of bones and muscles pain, phlegm-fire, decoct and order watery wine clothes." 2. " Zhiwu Mingshi Tukao ": " controls haematemesis, stimulates the menstrual flow, strong muscle, and strong bone, mends waist kidney, born fluid." 3. " will planted by middle traditional Chinese medicines ": " controls chronic consumptive disease, cough-relieving." 4. " Chongqing medical herbs ": " controls weak consumptive disease, cough, leucorrhea." 5. " Chinese herbal medicine is commonly used in Sichuan ": " expelling wind and removing dampness, spasmolytic is throbbed with fear, night sweat.Control consumptive disease wound to spit blood, soreness of bones and muscles, rheumatic arthritis, infantile convulsion stucks out one's tongue, fistula of tuberculous lymphadenitis carbuncle." 6. " Shaanxi Chinese herbal medicine ": " kidney invigorating and YANG supporting, regulating menstruation and activating blood, astringing to arrest bleeding.Control cough due to consumptive disease, night sweat of suffering from a deficiency of the kidney, weakness of the waist and knees, rheumatism and rheumatoid arthritis, hemiplegia, metrorrhagia, leucorrhea, conjunctivitis, various hemorrhage."
Radix Saposhnikoviae: [nature and flavor] Xin Gan, temperature.1. " herbal classic ": " sweet in the mouth, temperature." 2. " not Lu ": " be pungent, nontoxic." 3. " medicineization justice ": " gas and, sweet in the mouth is micro-pungent, slightly warm in nature." 4. " book on Chinese herbal medicine is new again ": " acrid in the mouth, property is put down, nontoxic." [return through] enters bladder, lung, spleen channel.1. " pearl sac ": " this medicine of Taiyang channel." 2. Materia Medica of Decoction: " stomach of foot Yang Ming, spleen of Foot-Taiyin two are through it medicine of passing through." 3. " Thunder God concocts property of medicine solution " > Thunder God process of preparing Chinese medicine property of medicine solution ": " enter lung meridian." 4. " book on Chinese herbal medicine is new again ": " enters liver,spleen,kidney three warp." [function cures mainly] delivers, and dispels the wind, and victory is wet, pain relieving.Control affection of exogenous wind-cold, headache, dizzy, stiffness of the nape, anemofrigid-damp arthralgia, joint is ached, and extremity contraction is anxious, tetanus.1. " herbal classic ": " main large dizziness due to wind pain, aversion to wind, ailment said due to cold or exposure, order blindness, is in fashion the whole body, arthralgia numbness, stuffy sensation with restlessness." 2. Collective Notes to the Canon of Materia medica: " kills Radix Aconiti Lateralis Preparata poison." 3. " not Lu ": " hypochondriac pain, side of body public attention face is gone, and extremity contraction is anxious, convulsion in word milk gold skin ulcer." 4. " Japan hanako materia medica ": " controls wind as 36, and all labor of man are bad, invigorating middle warmer benefit god, blepharitis marginalis, and arresting lacrimation and paralysis delay, tonneau the five internal organs GUAN-pulse, five kinds of strain and seven kinds of impairment, thin damage night sweat, vexed body weight, energy tranquilizing the mind, even gaseous pulse." 5. " pearl sac ": " body: go windward, the tip: go leeward.It is general that " 6. " medicine class on the analogy of natural things ": " controls wind.Eliminating the pathogens from the lung is real, and stagnant gas in the loose head, except part of the body cavity above the diaphragm housing the heart and lungs ailment said due to cold or exposure." 7. king accounts for well: " searches irritability." 8. " Changsha medicine solution ": " network of passing through, by wet excessive, gets round by bribery, and relieve the pain pain, and relaxing muscles and tendons arteries and veins, stretches anxious contraction, podomere of living, and plays paralysis, holds back spontaneous perspiration, helmet antiperspirant, break, metrorrhagia." 9. " book on Chinese herbal medicine asks former ": " separates Aconitum carmichjaelii Debx., Flos Genkwa, all medicine of a warm nature poison of wild bacterium."
Herba avenae fatuae: [habitats distribution] ecological environment: 1. wild oat is born in uncultivated field.2. smooth bran wild oat is born in patana, roadside and farmland.Resource distribution: 1. wild oat is distributed in various places, China north and south.2. smooth bran wild oat is distributed in various places, China north and south.[nature and flavor] are sweet; Flat.[function cures mainly] astringing to arrest bleeding; Strengthening superficial resistance to stop perspiration.Main haematemesis; Have blood in stool; Metrorrhagia; Spontaneous perspiration; Night sweat; Leucorrhea.
The present invention preferably only has above raw medicinal material to obtain.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 decoction
Formula: Fructus Ilicis Purpureae 16g, Hepar Sus domestica 8g, Hepar Caprae seu ovis 7g, Cornu Cervi 2g, Fructus Lycii 12g, Flos Caryophylli 16g, Radix Dipsaci 6g, Radix Achyranthis Bidentatae 9g, Fructus Amomi 13g, Semen Astragali Complanati 17g, Fructus Mori 18g, Semen Ziziphi Spinosae 13g, Semen pini koraiensis 16g, semen juglandis 16g, Radix Codonopsis Convolvulaceae 16g, Ganoderma 8g, Succus Bambusae 12g, Placenta Hominis 5g, Carnis Arca inflata 7g, Rhizoma Cibotii 8g, Caulis Sacchari sinensis 16g, Herba Eupatorii Heterophylli 15g, Radix seu Caulis Parabarii 8g, Herba Pyrolae 15g, Radix Saposhnikoviae 15g, Herba avenae fatuae 15g, Radix Tylophorae arenicolae 8g, Semen vignae sinensis 15g, Rhizoma Polygonati Cirrhifolii 3g, musk orchid 16g, Carnis Trionycis 8g.
Its preparation method is:
Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 3cm, soak 5 hours;
Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 200ml, filters, obtain filtrate a, for subsequent use;
Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 3cm, soaks 5 hours;
Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 45 minutes dosage to medicinal liquid be slowly 200ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.
Embodiment 2 granule
Formula: Fructus Ilicis Purpureae 16g, Hepar Sus domestica 8g, Hepar Caprae seu ovis 7g, Cornu Cervi 1g, Fructus Lycii 12g, Flos Caryophylli 16g, Radix Dipsaci 8g, Radix Achyranthis Bidentatae 10g, Fructus Amomi 12g, Semen Astragali Complanati 16g, Fructus Mori 16g, Semen Ziziphi Spinosae 15g, Semen pini koraiensis 16g, semen juglandis 16g, Radix Codonopsis Convolvulaceae 18g, Ganoderma 8g, Succus Bambusae 12g, Placenta Hominis 5g, Carnis Arca inflata 6g, Rhizoma Cibotii 8g, Caulis Sacchari sinensis 16g, Herba Eupatorii Heterophylli 18g, Radix seu Caulis Parabarii 9g, Herba Pyrolae 15g, Radix Saposhnikoviae 16g, Herba avenae fatuae 18g, Radix Tylophorae arenicolae 9g, Semen vignae sinensis 15g, Rhizoma Polygonati Cirrhifolii 3g, musk orchid 18g, Carnis Trionycis 8g.
Its preparation method is:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 times, mixture is the ethanol of 80%, be heated to boiling reflux 3 hours, filter, adopt percolation with the speed of 1ml per minute slowly percolation, collect percolate, when being evaporated to 50 DEG C subsequently under vacuum 0.06Mpa, relative density is the mastic of 1.14, spraying dry, the inlet temperature 160 DEG C of spray dryer, leaving air temp 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.1 times and 0.1 times in the dried cream powder obtained, makes granule, in 50 DEG C of dryings, obtains granule.
Embodiment 3 capsule
Formula: Fructus Ilicis Purpureae 19g, Hepar Sus domestica 8g, Hepar Caprae seu ovis 10g, Cornu Cervi 2g, Fructus Lycii 12g, Flos Caryophylli 18g, Radix Dipsaci 8g, Radix Achyranthis Bidentatae 9g, Fructus Amomi 18g, Semen Astragali Complanati 18g, Fructus Mori 17g, Semen Ziziphi Spinosae 16g, Semen pini koraiensis 17g, semen juglandis 16g, Radix Codonopsis Convolvulaceae 15g, Ganoderma 8g, Succus Bambusae 12g, Placenta Hominis 6g, Carnis Arca inflata 6g, Rhizoma Cibotii 8g, Caulis Sacchari sinensis 16g, Herba Eupatorii Heterophylli 16g, Radix seu Caulis Parabarii 12g, Herba Pyrolae 17g, Radix Saposhnikoviae 12g, Herba avenae fatuae 16g, Radix Tylophorae arenicolae 12g, Semen vignae sinensis 16g, Rhizoma Polygonati Cirrhifolii 3g, musk orchid 16g, Carnis Trionycis 8g.
Its preparation method is:
The first step, Fructus Ilicis Purpureae, Hepar Sus domestica, Hepar Caprae seu ovis, Cornu Cervi and Fructus Lycii are mixed in described ratio, add the water extraction volatile oil relative to 3 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 2, stirs 80 minutes, temperature 50 C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15;
Second step, Radix Achyranthis Bidentatae, Fructus Amomi, Semen Astragali Complanati, Fructus Mori and Semen Ziziphi Spinosae are mixed in described ratio, add relative to mixture 6 times amount determining alcohol be 80% alcohol reflux 4 times, each 2 hours, filter respectively, each time filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.10, for subsequent use;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 9 times of water gagings, boil 4 hours, filter, and when being concentrated into 60 DEG C, relative density is the clear paste of 1.18;
4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C of reduced vacuum dryings, get dry extract powder;
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100g and dried cream powder subsequently, 3g carboxymethyl starch sodium, 10g starch mix homogeneously, adding 100g determining alcohol is 80% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100g and dried cream powder subsequently, 3g magnesium stearate, then load in gelatine capsule.
Toxicity test
1. acute toxicity test: application NIH mice 40, SPF level, male and female half and half, body weight 18 ~ 22g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; Decoction gavage prepared by embodiments of the invention 1, gavage volume is 20ml/kg, and matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>20ml crude drug/kg of the present invention, every day, maximum dosage-feeding was 60ml crude drug/kg/ day.Chinese medicine clinical application amount of the present invention be 60ml crude drug/day/people, adult body weight in 60KG, average dosage is 1ml crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 20g) oral administration gavage Chinese medicine of the present invention is 60 times of quantity.Therefore Acute toxicity of the present invention is low, clinical drug safety.
2. long term toxicity test: the granule of the embodiment of the present invention 2 is pressed 8,16 and 40g crude drug/kg continuous use 12 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 12 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
3. cumulative toxicity test: test method: select 20 healthy mices, female, each 10 of hero, with the capsule of the embodiment of the present invention 3 for object, dose design is first phase in every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD 50,0.50LD50, the LD 50 that is female, male mice of this sample be 5000m part/k part BW (five dosage is 500,750,1100,1700,2500m part/k part BW).Within every 5 days, weigh once, adjustment dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose to tested material after 20 days, female, buck all occurs without death condition.Medicine of the present invention is described, does not there is cumulative toxicity.
Clinical trial
Treatment target: sufferers of osteoporosis face 200 example selecting year October in October, 2013 to 2014, patients symptomatic is: aching pain in waist and back, soreness of the waist and knees, tired unable, dry pharynx dryness of the tongue, feverish sensation in the palms and soles, night sweat spontaneous perspiration, red tongue with thin fur, less or no fur light, thready and rapid pulse.Be liver-kidney yin deficiency osteoporosis through tcm diagnosis.Wherein, man 101 example, female 99 example, age uneven distribution.Now will be divided into four groups at random, often organize 50 examples, embodiment 1 group, embodiment 2 groups, embodiment 3 groups and matched group.
Diagnostic criteria
(1) measure based on dxa: bone density value belongs to normal lower than the peak bone mass of same sex, agnate health adult less than 1 standard deviation; Reducing between 1 ~ 2.5 standard deviation is bone amount low (bone amount minimizing); It is osteoporosis that reduction degree is equal to and greater than 2.5 standard deviations; Bone density reduces degree and meets Criteria of Osteoporosis simultaneously with when a place or multiple fracture being severe osteoporosis.Now also usual by t-score(t value) represent, namely t value >=-1.0 are normal, and-2.5 value <-1.0 are that bone amount reduces, and t value≤-2.5 are osteoporosis.
(2) liver-kidney yin deficiency: aching pain in waist and back, soreness of the waist and knees, tired unable, dry pharynx dryness of the tongue, feverish sensation in the palms and soles, night sweat spontaneous perspiration, red tongue with thin fur, less or no fur light, thready and rapid pulse.
Therapeutic Method:
Embodiment 1 group: this is organized 50 routine patients and uses the decoction of the embodiment of the present invention 1 to treat.Every day twice, each 30ml 1 week is a course for the treatment of, treats 3 courses for the treatment of.
Embodiment 2 groups: this is organized 50 routine patients and uses the granule of the embodiment of the present invention 2 to treat.Every day twice, each 5g 1 week is a course for the treatment of, treats 3 courses for the treatment of.
Embodiment 3 groups: this is organized 50 routine patients and uses the capsule of the embodiment of the present invention 3 to treat.Every day twice, each 21 week is a course for the treatment of, treats 3 courses for the treatment of.
Matched group: this is organized 50 routine patients and uses Gushukang Capsule to treat.Oral one time 4. 2 times on the one 1 week is a course for the treatment of, treats 3 courses for the treatment of.
Criterion of therapeutical effect
Recovery from illness: clinical symptom disappearance, joint motion freely, recover daily life, obviously improve by osteoporosis; Effective: clinical symptoms disappears substantially, activity is acutely that diseased region still feels uncomfortable, and osteoporosis is improved; Invalid: clinical symptoms is without improvement.
Therapeutic outcome
Table 1 is the treatment situation contrast of each group
| Group | Recovery from illness | Effectively | Invalid |
| Embodiment 1 group | 48（96%） | 2（4%） | 0（0%） |
| Embodiment 2 groups | 49（98%） | 1（2%） | 0（0%） |
| Embodiment 3 groups | 50（100%） | 0（0%） | 0（0%） |
| Matched group | 20（40%） | 16（32%） | 14（28%） |
As can be seen from Table 1, the therapeutic outcome of three embodiment groups is better than matched group, it can thus be appreciated that, medicine of the present invention, treatment liver-kidney yin deficiency osteoporosis, good effect.
Table 2 is the cure time contrast of each group
| Group | Recovery from illness | First course for the treatment of | Second course for the treatment of | 3rd course for the treatment of |
| Embodiment 1 group | 48 | 15（31.25%） | 20（41.67%） | 13（27.08%） |
| Embodiment 2 groups | 49 | 16（32.65%） | 18（36.73%） | 15（30.61%） |
| Embodiment 3 groups | 50 | 19（38%） | 18（36%） | 12（24%） |
| Matched group | 20 | 2（10%） | 5（25%） | 13（65%） |
As can be seen from Table 2, on the treatment time of three embodiment groups, in the patient of recovery from illness, the required course for the treatment of is less than matched group.It can thus be appreciated that medicine of the present invention, treatment liver-kidney yin deficiency osteoporosis, just can take effect in the short time, instant effect, good effect.
Table 3 is recurrence and the side effect contrast of each group
| Group | Recurrence | Side effect |
| Embodiment 1 group | 0 | 0 |
| Embodiment 2 groups | 0 | 0 |
| Embodiment 3 groups | 0 | 0 |
| Matched group | 5 | 3 |
As can be seen from Table 3, not there is side effect in treatment group of the present invention, and in the follow-up in later stage, the patient of recovery from illness is not recurred again.It can thus be appreciated that medicine of the present invention, treatment liver-kidney yin deficiency osteoporosis, has no side effect, and not easily recurs.
In sum, medicine of the present invention, treatment liver-kidney yin deficiency osteoporosis, good effect, instant effect, and not easily recur, and not there is toxic and side effects.
Model case: patient Lee, man, 55 years old, suffer from liver-kidney yin deficiency osteoporosis, existing 2 years, western medical treatment was not got better always, now adopted the granule of embodiments of the invention 2 to treat.Every day twice, each 5g 1 week is a course for the treatment of, treats 3 courses for the treatment of.After treatment, clinical symptom disappearance, recovery from illness, and have no toxic and side effects in therapeutic process.Later stage follows up half a year, does not recur.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (8)
1. the osteoporotic medicine for the treatment of liver-kidney yin deficiency, it is characterized in that, described medicine comprises following raw medicinal material: Fructus Ilicis Purpureae, Hepar Sus domestica, Hepar Caprae seu ovis, Cornu Cervi, Fructus Lycii, Flos Caryophylli, Radix Dipsaci, Radix Achyranthis Bidentatae, Fructus Amomi, Semen Astragali Complanati, Fructus Mori, Semen Ziziphi Spinosae, Semen pini koraiensis, semen juglandis, Radix Codonopsis Convolvulaceae, Ganoderma, Succus Bambusae, Placenta Hominis, Carnis Arca inflata, Rhizoma Cibotii, Caulis Sacchari sinensis, Herba Eupatorii Heterophylli, Radix seu Caulis Parabarii, Herba Pyrolae, Radix Saposhnikoviae, Herba avenae fatuae, Radix Tylophorae arenicolae, Semen vignae sinensis, Rhizoma Polygonati Cirrhifolii, musk orchid, Carnis Trionycis.
2. medicine according to claim 1, is characterized in that, the weight portion Soviet Union of described raw medicinal material is than being: Fructus Ilicis Purpureae 15-20 weight portion, Hepar Sus domestica 7-13 weight portion, Hepar Caprae seu ovis 5-12 weight portion, Cornu Cervi 1-3 weight portion, Fructus Lycii 10-14 weight portion, Flos Caryophylli 15-20 weight portion, Radix Dipsaci 5-12 weight portion, Radix Achyranthis Bidentatae 8-14 weight portion, Fructus Amomi 10-20 weight portion, Semen Astragali Complanati 15-20 weight portion, Fructus Mori 15-20 weight portion, Semen Ziziphi Spinosae 10-20 weight portion, Semen pini koraiensis 15-25 weight portion, semen juglandis 15-20 weight portion, Radix Codonopsis Convolvulaceae 12-23 weight portion, Ganoderma 6-12 weight portion, Succus Bambusae 10-15 weight portion, Placenta Hominis 3-7 weight portion, Carnis Arca inflata 5-10 weight portion, Rhizoma Cibotii 7-11 weight portion, Caulis Sacchari sinensis 15-20 weight portion, Herba Eupatorii Heterophylli 10-20 weight portion, Radix seu Caulis Parabarii 8-13 weight portion, Herba Pyrolae 10-20 weight portion, Radix Saposhnikoviae 10-20 weight portion, Herba avenae fatuae 15-23 weight portion, Radix Tylophorae arenicolae 7-13 weight portion, Semen vignae sinensis 10-20 weight portion, Rhizoma Polygonati Cirrhifolii 2-5 weight portion, musk orchid 15-23 weight portion, Carnis Trionycis 6-13 weight portion.
3. medicine according to claim 1 and 2, is characterized in that, the ratio of weight and number of described raw medicinal material is: Fructus Ilicis Purpureae 18-20 weight portion, Hepar Sus domestica 7-10 weight portion, Hepar Caprae seu ovis 9-12 weight portion, Cornu Cervi 1-3 weight portion, Fructus Lycii 10-14 weight portion, Flos Caryophylli 15-20 weight portion, Radix Dipsaci 5-10 weight portion, Radix Achyranthis Bidentatae 8-10 weight portion, Fructus Amomi 15-20 weight portion, Semen Astragali Complanati 15-20 weight portion, Fructus Mori 15-20 weight portion, Semen Ziziphi Spinosae 15-20 weight portion, Semen pini koraiensis 15-20 weight portion, semen juglandis 15-20 weight portion, Radix Codonopsis Convolvulaceae 12-20 weight portion, Ganoderma 6-12 weight portion, Succus Bambusae 10-15 weight portion, Placenta Hominis 5-7 weight portion, Carnis Arca inflata 5-10 weight portion, Rhizoma Cibotii 7-11 weight portion, Caulis Sacchari sinensis 15-20 weight portion, Herba Eupatorii Heterophylli 15-20 weight portion, Radix seu Caulis Parabarii 10-13 weight portion, Herba Pyrolae 15-20 weight portion, Radix Saposhnikoviae 10-15 weight portion, Herba avenae fatuae 15-20 weight portion, Radix Tylophorae arenicolae 10-13 weight portion, Semen vignae sinensis 15-20 weight portion, Rhizoma Polygonati Cirrhifolii 2-5 weight portion, musk orchid 15-20 weight portion, Carnis Trionycis 6-10 weight portion.
4. the medicine according to any one of claims 1 to 3, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Fructus Ilicis Purpureae 16 weight portion, Hepar Sus domestica 8 weight portion, Hepar Caprae seu ovis 7 weight portion, Cornu Cervi 1 weight portion, Fructus Lycii 12 weight portion, Flos Caryophylli 16 weight portion, Radix Dipsaci 8 weight portion, Radix Achyranthis Bidentatae 10 weight portion, Fructus Amomi 12 weight portion, Semen Astragali Complanati 16 weight portion, Fructus Mori 16 weight portion, Semen Ziziphi Spinosae 15 weight portion, Semen pini koraiensis 16 weight portion, semen juglandis 16 weight portion, Radix Codonopsis Convolvulaceae 18 weight portion, Ganoderma 8 weight portion, Succus Bambusae 12 weight portion, Placenta Hominis 5 weight portion, Carnis Arca inflata 6 weight portion, Rhizoma Cibotii 8 weight portion, Caulis Sacchari sinensis 16 weight portion, Herba Eupatorii Heterophylli 18 weight portion, Radix seu Caulis Parabarii 9 weight portion, Herba Pyrolae 15 weight portion, Radix Saposhnikoviae 16 weight portion, Herba avenae fatuae 18 weight portion, Radix Tylophorae arenicolae 9 weight portion, Semen vignae sinensis 15 weight portion, Rhizoma Polygonati Cirrhifolii 3 weight portion, musk orchid 18 weight portion, Carnis Trionycis 8 weight portion.
5. the medicine according to any one of Claims 1-4, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Fructus Ilicis Purpureae 19 weight portion, Hepar Sus domestica 8 weight portion, Hepar Caprae seu ovis 10 weight portion, Cornu Cervi 2 weight portion, Fructus Lycii 12 weight portion, Flos Caryophylli 18 weight portion, Radix Dipsaci 8 weight portion, Radix Achyranthis Bidentatae 9 weight portion, Fructus Amomi 18 weight portion, Semen Astragali Complanati 18 weight portion, Fructus Mori 17 weight portion, Semen Ziziphi Spinosae 16 weight portion, Semen pini koraiensis 17 weight portion, semen juglandis 16 weight portion, Radix Codonopsis Convolvulaceae 15 weight portion, Ganoderma 8 weight portion, Succus Bambusae 12 weight portion, Placenta Hominis 6 weight portion, Carnis Arca inflata 6 weight portion, Rhizoma Cibotii 8 weight portion, Caulis Sacchari sinensis 16 weight portion, Herba Eupatorii Heterophylli 16 weight portion, Radix seu Caulis Parabarii 12 weight portion, Herba Pyrolae 17 weight portion, Radix Saposhnikoviae 12 weight portion, Herba avenae fatuae 16 weight portion, Radix Tylophorae arenicolae 12 weight portion, Semen vignae sinensis 16 weight portion, Rhizoma Polygonati Cirrhifolii 3 weight portion, musk orchid 16 weight portion, Carnis Trionycis 8 weight portion.
6. the medicine according to any one of claim 1 to 5, is characterized in that, the dosage form of described medicine is decoction, and its preparation method comprises the following steps:
Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 2-5cm, soak 3-8 hour;
Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 200-300ml, filters, obtain filtrate a, for subsequent use;
Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 4-10 hour;
Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 45-55 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.
7. the medicine according to any one of claim 1 to 5, is characterized in that, the dosage form of described medicine is granule, and its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 3 ~ 7 times, mixture is the ethanol of 80% ~ 90%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.14 ~ 1.20, spraying dry, the inlet temperature 160 ~ 170 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.1 ~ 0.3 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
8. a preparation method for the medicine described in any one of claim 1 to 5, is characterized in that, the dosage form of described medicine is capsule, and its preparation method comprises the following steps:
The first step, Fructus Ilicis Purpureae, Hepar Sus domestica, Hepar Caprae seu ovis, Cornu Cervi and Fructus Lycii are mixed in described ratio, add the water extraction volatile oil relative to 3 ~ 5 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 1 ~ 3, stirs 60 minutes ~ 90 minutes, temperature 40 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.12 ~ 1.15;
Second step, Radix Achyranthis Bidentatae, Fructus Amomi, Semen Astragali Complanati, Fructus Mori and Semen Ziziphi Spinosae are mixed in described ratio, add relative to mixture 5 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter respectively, each time filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.10 ~ 1.12, for subsequent use;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 3 ~ 5 hours, filter, and when being concentrated into 60 DEG C, relative density is the clear paste of 1.18 ~ 1.20;
4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 2 ~ 5 weight portion carboxymethyl starch sodium, 3 ~ 30 weight starch mix homogeneously, adding 100 ~ 150 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 1 ~ 3 weight portion magnesium stearate, then loads in gelatine capsule.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1475252A (en) * | 2003-06-27 | 2004-02-18 | 冷向阳 | Medicine for treating osteoporosis and its preparation method |
| CN1864710A (en) * | 2005-05-19 | 2006-11-22 | 北京燕京中科生物技术有限公司 | A medicine for treating osteoporosis |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1475252A (en) * | 2003-06-27 | 2004-02-18 | 冷向阳 | Medicine for treating osteoporosis and its preparation method |
| CN1864710A (en) * | 2005-05-19 | 2006-11-22 | 北京燕京中科生物技术有限公司 | A medicine for treating osteoporosis |
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