CN1273153C - Chinese medicinal preparation for treating pharyngolaryngitis and its manufacturing method - Google Patents

Abstract

The present invention relates to a Chinese materia medica preparation for treating pharyngitis and a preparation method thereof. The Chinese materia medica preparation is prepared by extracting, refining and purifying woodfordia fruticos, liquoric root, baical skullcap root and borneol. Compared with the existing Chinese materia medica preparations, the Chinese materia medica preparation adopts advanced technologies of adsorption, separation and purification with macroporous resin to collect effective components and has the advantages of advanced technology, stable quality of products, secure and effective clinical use and controllable quality. The results of pharmacodynamics experiments and preliminary clinical verification show that the Chinese materia medica preparation has obvious action of antisepsis, antivirus, heat removal and anti-inflammation and can be used for treating diseases of pharyngalgia, dry pharynx and burning sensation of throats, dysphagia, etc. caused by sphagitis, tonsillitis, common colds, coughs, etc.

Description

Chinese medicine preparation of treatment pharyngitis and preparation method thereof

Technical field: the present invention is a kind of Chinese medicine preparation for the treatment of pharyngitis and preparation method thereof, belongs to the field of traditional Chinese medicine technology.

Technical background: acute pharyngitis is a kind of common clinical, frequently-occurring disease, for one of common acute infectious diseases of respiratory tract, is more common in winter and spring; But Epidemiological study result in recent years shows, the band air-conditioning place that is mainly in hot season in summer equally; Environmental pollutions such as industrial waste gas, dust, chemistry cause the primary disease sickness rate to raise, and male's sickness rate is more than the women.Clinical red swelling of the pharynx, scorching hot pain, the dysphagia of mainly showing as, dried discomfort and the foreign body sensation of itching, hoarseness, and symptom such as the heat that often occurs together, headache, general malaise, inappetence, thirsty and constipation.The primary disease onset is anxious, and as untimely treatment, prolong with the course of disease and to increase the weight of easily to transfer to chronic pharyngitis and cause mucosal atrophy, hypertrophy, cancerate, and diseases such as bronchial asthma, pneumonia, have a strong impact on human body health and work and study.The existing herbal species that is used for the treatment of this disease has: the upright refreshing drop pill of pharynx, silver-colored Pu detoxifcation sheet, pharynx-clearing throat-benefiting granule, liyan jiedu granule, fall ball, JINSANGZIHOUBAO or the like clearly, but they exist preparation technology simple mostly, the easy moisture absorption of finished product, storage-stable is poor, quality is wayward, and what have has shortcomings such as side reaction to gastrointestinal tract.Advantages such as this product adopts modern macroporous adsorption resin technology, is that the basis is studied technology with the pharmacodynamics test, has preparation technology advanced person, and finished product is nonhygroscopic, and storage-stable is good, and quality is easy to control, and clinical efficacy is definite.

The objective of the invention is to: the geographic proved recipe of China's southwest minority is studied, develop a kind of manufacture method for the treatment of the Chinese medicine preparation and this medicine thereof of pharyngitis, overcoming the problem that prior art exists, also provide a kind of active drug of new treatment acute pharyngitis simultaneously to the patient.

The present invention constitutes like this: a kind of Chinese medicine preparation for the treatment of pharyngitis, by weight ratio, it is formed by 3～8 parts of Herba Inulae cappae, 2～5 parts in Radix Glycyrrhizae, 1～3 part of Radix Scutellariae, 0.03～0.06 part of prescription of Borneolum Syntheticum.Specifically: according to weight proportion: form by 5 parts of Herba Inulae cappae, 2 parts in Radix Glycyrrhizae, 1 part of Radix Scutellariae, 0.04 part of prescription of Borneolum Syntheticum.The said preparation of the present invention is a said dosage form on any pharmaceutics; Preferably buccal tablet or drop pill.The manufacture method of this Chinese medicine preparation of treatment pharyngitis is: according to given weight proportion, with Herba Inulae cappae, Radix Glycyrrhizae decocts with water, and filters, filtrate is condensed into extractum, handles with ethanol precipitation, reclaims ethanol, macroporous adsorptive resins on the aqueous solution discards and penetrates liquid, uses ethanol elution, collect eluent, reclaim ethanol, concentrate, drying gets Herba Inulae cappae, Radix Glycyrrhizae extract, Radix Scutellariae decocts with water, filter, filtrate is transferred pH1～2 with hydrochloric acid, insulation, leave standstill, extract precipitate, drying, get the baicalin crude extract, Borneolum Syntheticum is made into saturated solution with ethanol, slowly adds in the beta-schardinger dextrin-saturated aqueous solution and prepares Benexate Hydrochloride, drying, standby, above-mentioned two kinds of extracts and Benexate Hydrochloride add appropriate amount of auxiliary materials, essence, mixing adopts existing preparation technique to make buccal tablet or drop pill.Manufacture method provided by the invention can be according to given weight proportion, with Herba Inulae cappae, Radix Glycyrrhizae, Radix Scutellariae merges or divides other to decoct with water, filter, filtrate is transferred pH6～6.5 with sodium hydroxide, concentrates, handle with ethanol precipitation, reclaim ethanol, macroporous adsorptive resins on the aqueous solution, discard and penetrate liquid, use ethanol elution, collect eluent, reclaim ethanol, concentrate, drying gets extract, and Borneolum Syntheticum is made into saturated solution with ethanol, slowly add in the beta-schardinger dextrin-saturated aqueous solution and prepare Benexate Hydrochloride, drying, standby, extract and Benexate Hydrochloride are added appropriate amount of auxiliary materials, essence, mixing adopts existing preparation technique to make the dosage form that needs.Manufacture method provided by the invention can also be according to given weight proportion, with Herba Inulae cappae, Radix Glycyrrhizae decocts with water, filter, filtrate is condensed into extractum, handles with ethanol precipitation, reclaim ethanol, macroporous adsorptive resins on the aqueous solution discards and penetrates liquid, use ethanol elution, collect eluent, reclaim ethanol, concentrate, drying gets Herba Inulae cappae, Radix Glycyrrhizae extract, Radix Scutellariae decocts with water, and filters, and filtrate is transferred pH1～2 with hydrochloric acid, insulation, leave standstill, extract precipitate, drying, get the baicalin crude extract, above-mentioned two kinds of extracts add Borneolum Syntheticum, appropriate amount of auxiliary materials, essence, mixing adopts existing preparation technique to make the dosage form that needs.Manufacture method provided by the invention, also can be according to given weight proportion, Herba Inulae cappae, Radix Glycyrrhizae, Radix Scutellariae are merged or decoct with water separately, filter, filtrate is condensed into extractum, add appropriate amount of auxiliary materials and receive cream, granulate drying, granulate, spray into Borneolum Syntheticum ethanol liquid, airtight, adopt existing preparation technique to make the dosage form that needs.The present invention can also decoct with water Herba Inulae cappae, Radix Glycyrrhizae according to given weight proportion, filters, and filtrate is condensed into extractum, handle with ethanol precipitation, reclaim ethanol, concentrate drying, get Herba Inulae cappae, Radix Glycyrrhizae extract, Radix Scutellariae decocts with water, and filters filtrate, transfer pH1～2 with hydrochloric acid, insulation is left standstill, and extracts precipitate, drying gets the baicalin crude extract, and the said extracted thing adds appropriate amount of auxiliary materials and granulates drying, granulate sprays into Borneolum Syntheticum ethanol liquid, and is airtight, adopts existing preparation technique to make the dosage form that needs.The concrete preparation technology that the present invention is pressed into tablet is: Herba Inulae cappae, Radix Glycyrrhizae are decocted with water 3 times, filter, merging filtrate is evaporated to debita spissitudo, adds ethanol and makes that to contain the alcohol amount be 60%, leaves standstill, and sucking filtration reclaims ethanol, adds suitable quantity of water dilution dissolving.Last macroporous adsorptive resins (blade diameter length ratio 1: 6, absorption flow velocity 2BVh-1, BV-wet column volume) discards and penetrates liquid, with debita spissitudo ethanol elution (elution flow rate 2BVh-1), collects eluent, reclaims ethanol, concentrating under reduced pressure, and drying, pulverizing, standby.Radix Scutellariae decocts with water 2 times, filters, and merging filtrate is transferred pH1～2,80 ℃ insulation with hydrochloric acid, leaves standstill, and extracts precipitate, and drying gets the baicalin crude extract, pulverizes, and is standby.Borneolum Syntheticum is made into saturated solution with ethanol, slowly adds in the beta-schardinger dextrin-saturated aqueous solution, and cryogenic thermostat stirred 2 hours, and cold preservation is spent the night, sucking filtration, and 40 ℃ of dryings are pulverized, and are standby.Above-mentioned two kinds of extracts and Benexate Hydrochloride add appropriate amount of auxiliary materials, essence, and mixing is granulated drying, granulate.Add an amount of magnesium stearate, mixing is pressed into tablet, promptly.

Among the prescription that the present invention constitutes; Herba Inulae cappae: the wind heat clearing away of loosing, removing toxic substances and promoting subsidence of swelling.Be used for cold, fever, laryngopharynx swelling and pain, rheumatalgia, carbuncle skin ulcer furunculosis, mastitis." Guizhou natural resources of Chinese medicinal materials ": heat clearing away, tonify deficiency, expectorant Dingchuan." Chinese ethnic drug will " record: Miao ethnic group: be used for tonsillitis, bronchitis, gingivitis, mastitis.The Yao nationality: the detumescence of dispeling the wind, promoting the circulation of QI to relieve pain, expelling cold and relieving exterior syndrome.The Yi nationality, distributed over Yunnan, Sichuan and Guizhou: clearing away heat-fire.Be used for toothache, urinary tract infection.Zhuang: heat-clearing and toxic substances removing, the emaciation due to emotional upset that looses is swollen.Be used for cold, fever, laryngopharynx swelling and pain, rheumatalgia, carbuncle skin ulcer furunculosis, acute mastitis.The Dai nationality is used for infantile fever.Decocting liquid all has better action to staphylococcus aureus, escherichia coli, Song Shi dysentery bacterium.Clinical acute tonsillitis, chronic bronchial pharynx, the arthritis etc. of being used for the treatment of.Radix Scutellariae: nature and flavor hardship, cold.Return lung, stomach, gallbladder, large intestine channel.The function heat clearing and damp drying, eliminating fire and detoxication, cooling blood for hemostasis, heat extraction is antiabortive.Be used for the hygropyrexia heat-damp in summer, damp and hot painful abdominal mass is vexed, the jaundice dysentery, and the cough due to lung-heat, the calentura excessive thirst, carbuncle sore tumefacting virus, laryngopharynx swelling and pain, heat in blood is told nosebleed, excessive fetal movement due to heat in pregnancy." book on Chinese herbal medicine warp ": " Dingchuan is coughed, and only loses blood, and moves back alternate attacks of chills and fever for the fire of the clear part of the body cavity above the diaphragm housing the heart and lungs of withered person, expectorant promoting the circulation of QI, and wind heat is damp and hot, and pestilence is separated in headache, and consumptive lung disease, acute mastitis carbuncle on the back are treated in moistening and cleaning throat, the heat of the flesh table of dispelling especially ...." " medicine origin ": " Radix Scutellariae is controlled in the lung damp and hotly, and swollen red in the hot order in the treatment, blood stasis is stopped up and contained the medicine that must use." " wine is fried up, Your Majesty portion hematocele, and non-this can not remove, the lung being apt to suffer from adverse rising of QI, anxious food bitter flavor having purgating effect is just being called this also." Radix Glycyrrhizae: nature and flavor are sweet, flat.GUIXIN, lung, spleen, stomach warp.The function expelling phlegm for arresting cough, heat-clearing and toxic substances removing, relieving spasm to stop pain, the mediation property of medicine.Give birth to cooler the energy heat-clearing and toxic substances removing; Process the property used pestilence, energy QI invigorating tonify deficiency; Its sweet slow property again can relieving spasm to stop pain.Can be used for controlling weakness of the spleen and stomach, deficiency of QI in middle-JIAO, deficiency of vital energy insufficiency of blood, activity palpitation in the heart, phlegmatic cough cough with asthma, the disease of stomachache contraction urgency and sore swollen toxin.Owing to can be in harmonious proportion the property of medicine again, separate hundred poison of drug, can delay its heat with what the medicine of a warm nature was used, can delay with cold medicinal that it is cold, can make and mend and not rapid, make and rush down and be unlikely speed.Radix Glycyrrhizae has 17-hydroxy-11-dehydrocorticosterone sample antiinflammatory action, and congestion and edema and the adenoid hypertrophy of improving mucosa had curative effect preferably.Borneolum Syntheticum: the property suffering, hardship is slightly cold.GUIXIN, spleen, lung meridian.The function refreshment of having one's ideas straightened out, clearing away heat to alleviate pain, improving acuity of vision and removing nebula.The hot hardship of loosing of Borneolum Syntheticum is rushed down, and fragrance is walked to scurry, and can lead to all keys, the stagnated fire of loosing.With training the mind will stupor, summer-heat is finally fainted, and the merit of the refreshment of having one's ideas straightened out of similar Moschus is arranged.External can be declared malicious pain relieving again, anticorrosion detumescence, improving acuity of vision and removing nebula.Be usually used in laryngopharynx swelling and pain, diseases such as ulcer of mouth-tongue, order disease, glue ear, carbuncle sore furunculosis poison.

Theory of Chinese medical science foundation of the present invention and prescription characteristics:

Acute pharyngitis belongs to the category of the traditional Chinese medical science " acute pharyngitis due to wind-heat ".The traditional Chinese medical science thinks that primary disease is many because of wind-heat evil toxin invasion and attack throat, wind being YANG-pathogen, and sun is subjected on the wind heat from transconversion into heat, and internal injury is in lung, and wind heat is stifling cleans the street, and the key road is unfavorable, causes the swelling throat plug and is disease; Or because of the pungent scorching product of surfeit usually, the taste intrinsic heat, the gas of pyretic toxicity must not be led off, on attack throat and be disease; Or stop up to contain because of pathogenic heat, to defend in the biography by lung, pathogenic heat is followed through the throat of burning, and makes laryngopharynx swelling and pain and causes inflammation of the throat.At evil poison of primary disease diseases caused by exogenous pathogenic factor and the long-pending heat of the lung stomach knot of fighting mutually, follow through on accumulate in pharynx, stop up the poly-etiology and pathogenesis that does not loose and form, it is controlled should wind and heat dispersing, resolving toxin and disinhibiting the throat.Herba Inulae cappae expelling wind and clearing away heat in the side, removing toxic substances and promoting subsidence of swelling are monarch; Radix Scutellariae hardship, cold.It is minister that clearing away heat-fire helps the principal agent heat-clearing and toxic substances removing; The hot hardship of loosing of Borneolum Syntheticum is rushed down, and the clearing away heat and cooling blood pain relieving is assistant; The Radix Glycyrrhizae sour and sweet drugs can transforme into YIN, relieving spasm to stop pain is for making.All medicines share, and wind and heat dispersing is arranged, and the merit of resolving toxin and disinhibiting the throat also can be received the effect of reducing swelling and alleviating pain.The patient who be used for that pharyngalgia due to flu, cough, pharyngolaryngitis, the tonsillitis etc., dry pharynx are scorching hot, dysphagia etc. is seen disease.

Compared with prior art, medicine provided by the invention has following characteristics:

(1) this product adopts modern macroporous adsorption resin technology, is that the basis is studied the technology of this product with the pharmacodynamics test.Herba Inulae cappae, Radix Glycyrrhizae are through the macroporous adsorption resin technology separation and purification in the side, total solid matters obviously reduces, Radix Scutellariae extracts the baicalin crude product, and Borneolum Syntheticum is prepared into buccal tablet or drop pill with the technology of beta-cyclodextrin inclusion compound, overcome the easy moisture absorption of Chinese traditional patent formulation preparation, storage inconvenience, day dose is big, and mouthfeel is poor, quality is wayward, shortcomings such as poor stability.

(2) this preparation is fast at the acute pharyngitis onset, and sick clinical characters at throat is according to the traditional Chinese medical science theory of " attacking heresy nearby ", make buccal tablet or drop pill is taken in small doses at short intervals, medicine directly acts on the throat, can improve the absorption of local pharyngeal mucous membrane to medicine, to obtain curative effect preferably.

(3) write out a prescription composition from traditional Chinese medical science clinical practice, draw traditional Chinese medical science tradition and medication experience among the people, select the medicine prescription according to pharyngitis clinical characters and adaptation syndrome.Reuse and have diffusing wind heat clearing away, the Herba Inulae cappae of resolving toxin and disinhibiting the throat, the fire that is aided with the clear part of the body cavity above the diaphragm housing the heart and lungs of Radix Scutellariae helps the merit of Herba Inulae cappae heat-clearing and toxic substances removing, Borneolum Syntheticum, Radix Glycyrrhizae clearing heat for detumescence, relieving spasm to stop pain gathers wind and heat dispersing, resolving toxin and disinhibiting the throat, the merit of reducing swelling and alleviating pain.Prescription meets theory of Chinese medical science, and certain characteristic is arranged, and clinical efficacy is definite, and for absorbing national folk clinical practice proved recipe, effective, safe, the inexpensive Chinese patent medicine of exploitation treatment acute pharyngitis illness has important practical significance and extensive market prospects.

Clinical settings data and pharmacodynamics test summary

1. results of pharmacodynamic test shows: this product can alleviate rat and mice foot swelling due to the carrageenin, alleviate mice ear degree due to the dimethylbenzene, reduce sodium carboxymethyl cellulose induced mice abdominal cavity leukoplania; Can suppress that rat temperature due to the yeast raises and endotoxin raise to rabbit body temperature; Increase the weight of mouse immune organ, improve the phagocytic index of mice reticuloendothelial system and engulf coefficient, increase the generation of mice hemolytic antibody; Each dosage group does not have obvious influence to the body number of times of turning round of mice pain threshold and acetic acid induced mice.The yellow supernatant buccal tablet of chrysanthemum causes the mouse lung pathological changes to influenza virus FM1 obvious inhibitory action; Influenza virus Mus FM1, adenovirus-7 and the clinical influenza virus B/ Guizhou Province of separating are prevented that/252/2001 infecting mouse death has significant protective effect; The propagation that can obviously suppress influenza virus FM1 in the mice body; Respiratory syncytial virus, parainfluenza virus I type, adenovirus-7 cytopathogenic effect all there is different inhibitory action; Under the Embryo Gallus domesticus condition of culture, the influenza virus A type capital 86-1 of section is prevented that with the clinical influenza virus B/ Guizhou Province of separating/252/2001 infection has certain prevention and therapeutical effect.Staphylococcus aureus, beta hemolytic streptococcus, Jia Xingrongxuexinglianqiujun, Diplococcus pneumoniae, meningococcus, hemophilus influenza, Bacillus proteus, escherichia coli, bacillus pyocyaneus type strain and clinical strain all there is significantly antibacterial and bactericidal action; Middle and high dosage group is to the deadly protective effect that all has in various degree of staphylococcus aureus, beta hemolytic streptococcus, Jia Xingrongxuexinglianqiujun, hemophilus influenza, Diplococcus pneumoniae, bacillus pyocyaneus type strain and clinical strain infecting mouse.The result shows that this medicine has the effect of tangible antiinflammatory, antibiotic, antiviral, analgesic and raise immunity.

2. clinical test results shows: case choice criteria (contain diagnosis, include in, exclusion standard), observation index, efficacy assessment standard, and all with reference to " the clinical research guideline of new Chinese medicine treatment acute pharyngitis ".Include anemopyretic acute pharyngitis patient 60 examples in, be divided into treatment at random according to treatment group and 2: 1 ratio of matched group and organize 40 examples, matched group 20 examples.The treatment group is taken the yellow supernatant buccal tablet of chrysanthemum, each 1,6 times on the 1st; Matched group is taken FUFANG CAOSHANHU HANPIAN, each 2,2 hours 1 time, 6 times on the 1st, is 5 days the course of treatment.Viewing duration, two groups of patients all must not take the treatment acute pharyngitis in, western drug.The result shows: treatment group and matched group on sex, age, state of an illness integration, the course of disease distribute by statistics credit analyse, difference that there are no significant (P＞0.05), distributing equilibrium between the explanation group has comparability.Treatment group cure-remarkable-effectiveness rate reaches more than 70%, and total effective rate reaches more than 90%; Compare there was no significant difference (P＞0.05) with matched group.Symptoms such as two medicines are scorching hot to pharyngalgia, dysphagia, dry pharynx, fever with chills, thirsty, cough, the pharyngeal mucous membrane hyperemia effect that all is significantly improved.In the observation process, do not find obvious adverse reaction, blood, urine, stool routine examination and ALT, BNN, Electrocardioscopy no abnormality seen change before and after the treatment.

Embodiments of the invention 1:

According to weight proportion: form by 5 parts of Herba Inulae cappae, 2 parts in Radix Glycyrrhizae, 1 part of Radix Scutellariae, 0.04 part of prescription of Borneolum Syntheticum.Herba Inulae cappae, Radix Glycyrrhizae are decocted with water, filter, filtrate is condensed into extractum, handles with ethanol precipitation, reclaims ethanol, macroporous adsorptive resins on the aqueous solution discards and penetrates liquid, with an amount of concentration ethanol eluting, collects eluent, reclaim ethanol, concentrate, drying gets Herba Inulae cappae, Radix Glycyrrhizae extract.Radix Scutellariae decocts with water, and filters, and filtrate is transferred pH1～2 with hydrochloric acid, and insulation is left standstill, and extracts precipitate, and drying gets the baicalin crude extract.Borneolum Syntheticum is made into saturated solution with ethanol, and slowly add in the beta-schardinger dextrin-saturated aqueous solution and prepare Benexate Hydrochloride, drying, standby.Above-mentioned two kinds of extracts and Benexate Hydrochloride add appropriate amount of auxiliary materials, essence, and mixing adopts existing preparation technique to make buccal tablet.

Embodiments of the invention 2:

Can 3 kilograms of Herba Inulae cappae, 2 kilograms of Radix Glycyrrhizaes, 1 kilogram of Radix Scutellariae be decocted with water according to given weight proportion, filter, filtrate is transferred pH6～6.5 with sodium hydroxide, concentrates, and handles with ethanol precipitation, reclaim ethanol, macroporous adsorptive resins on the aqueous solution discards and penetrates liquid, with an amount of concentration ethanol eluting, collect eluent, reclaim ethanol, concentrate, drying gets extract.0.03 the kilogram Borneolum Syntheticum is made into saturated solution with ethanol, and slowly add in the beta-schardinger dextrin-saturated aqueous solution and prepare Benexate Hydrochloride, drying, standby.Extract and Benexate Hydrochloride are added appropriate amount of auxiliary materials, essence, and mixing adopts existing preparation technique to make drop pill.

Embodiments of the invention 3:

Can 8 kilograms of Herba Inulae cappae, 5 kilograms of Radix Glycyrrhizaes, 3 kilograms of Radix Scutellariaes be decocted with water respectively according to given weight proportion, filter, filtrate is concentrated in right amount, mixes, and transfers pH6～6.5 with sodium hydroxide, handle with ethanol precipitation, reclaim ethanol, macroporous adsorptive resins on the aqueous solution, discard and penetrate liquid,, collect eluent with an amount of concentration ethanol eluting, reclaim ethanol, concentrate, drying gets extract.0.06 the kilogram Borneolum Syntheticum is made into saturated solution with ethanol, and slowly add in the beta-schardinger dextrin-saturated aqueous solution and prepare Benexate Hydrochloride, drying, standby.Extract and Benexate Hydrochloride are added appropriate amount of auxiliary materials, essence, and mixing adopts existing preparation technique to make tablet.

Embodiments of the invention 4:

5 kilograms of Herba Inulae cappae, 3 kilograms of Radix Glycyrrhizaes, 1.5 kilograms of Radix Scutellariaes are decocted with water, filter merging filtrate, be evaporated to debita spissitudo, add ethanol and make that to contain the alcohol amount be 60%, leave standstill, sucking filtration reclaims ethanol, concentrates, add appropriate amount of auxiliary materials, granulate granulate, spray into the Borneolum Syntheticum ethanol liquid made from 0.05 kilogram of Borneolum Syntheticum, mixing, airtight, adopt existing preparation technique to make oral agents.

Embodiments of the invention 5: 6 kilograms of Herba Inulae cappae, 4 kilograms of Radix Glycyrrhizaes are decocted with water 3 times, filter, merging filtrate is evaporated to debita spissitudo, adds ethanol and makes that to contain the alcohol amount be 60%, leaves standstill, and sucking filtration reclaims ethanol, adds suitable quantity of water dilution dissolving.Last macroporous adsorptive resins (blade diameter length ratio 1: 6, absorption flow velocity 2BVh-1, BV-wet column volume) discards and penetrates liquid, with debita spissitudo ethanol elution (elution flow rate 2BVh-1), collects eluent, reclaims ethanol, concentrating under reduced pressure, and drying, pulverizing, standby.2 kilograms of Radix Scutellariaes decoct with water 2 times, filter, and merging filtrate is transferred pH1～2,80 ℃ insulation with hydrochloric acid, leave standstill, and extract precipitate, and drying gets the baicalin crude extract, pulverizes, and is standby.0.05 the kilogram Borneolum Syntheticum is made into saturated solution with ethanol, slowly adds in the beta-schardinger dextrin-saturated aqueous solution, cryogenic thermostat stirred 2 hours, and cold preservation is spent the night, sucking filtration, and 40 ℃ of dryings are pulverized, and are standby.Above-mentioned two kinds of extracts and Benexate Hydrochloride add appropriate amount of auxiliary materials, essence, and mixing is granulated drying, granulate.Add an amount of magnesium stearate, mixing is pressed into tablet.

Claims (2)

1. Chinese medicine preparation for the treatment of pharyngitis is characterized in that: by weight ratio, its is with 3～8 parts of Herba Inulae cappae, 2～5 parts in Radix Glycyrrhizae, 0.03～0.06 part of 1～3 part of Radix Scutellariae and Borneolum Syntheticum are according to following method preparation: with Herba Inulae cappae, Radix Glycyrrhizae decocts with water, filter, filtrate is condensed into extractum, handles with ethanol precipitation, reclaim ethanol, macroporous adsorptive resins on the aqueous solution discards and penetrates liquid, use ethanol elution, collect eluent, reclaim ethanol, concentrate, dry, get Herba Inulae cappae, Radix Glycyrrhizae extract, Radix Scutellariae decocts with water, and filters, filtrate, transfer pH1～2 with hydrochloric acid, insulation is left standstill, extract precipitate, drying gets the baicalin crude extract, and Borneolum Syntheticum is made into saturated solution with ethanol, slowly add in the beta-schardinger dextrin-saturated aqueous solution and prepare Benexate Hydrochloride, drying, standby, above-mentioned two kinds of extracts and Benexate Hydrochloride add appropriate amount of auxiliary materials, essence, mixing adopts existing preparation technique to make buccal tablet or drop pill.

2. according to the Chinese medicine preparation of the described treatment pharyngitis of claim 1, it is characterized in that: according to weight proportion: get 5 parts of Herba Inulae cappae, 2 parts in Radix Glycyrrhizae, 0.04 part of 1 part of Radix Scutellariae and Borneolum Syntheticum are with Herba Inulae cappae, Radix Glycyrrhizae decocts with water 3 times, filter, merging filtrate is evaporated to debita spissitudo, add ethanol and make that to contain the alcohol amount be 60%, leave standstill sucking filtration, reclaim ethanol, add suitable quantity of water dilution dissolving, last macroporous adsorptive resins, discard and penetrate liquid, use the debita spissitudo ethanol elution, collect eluent, reclaim ethanol, concentrating under reduced pressure, drying, pulverize, standby, Radix Scutellariae decocts with water 2 times, filter, merging filtrate is transferred pH1～2,80 ℃ insulation with hydrochloric acid, leave standstill, extract precipitate, drying gets the baicalin crude extract, pulverize, standby, Borneolum Syntheticum is made into saturated solution with ethanol, slowly adds in the beta-schardinger dextrin-saturated aqueous solution, cryogenic thermostat stirred 2 hours, cold preservation is spent the night, sucking filtration, 40 ℃ of dryings, pulverize, standby, above-mentioned two kinds of extracts and Benexate Hydrochloride add appropriate amount of auxiliary materials, essence, mixing, granulate, drying adds an amount of magnesium stearate, mixing, be pressed into tablet, promptly.