CN112755102A - Pharmaceutical composition for treating piglet diarrhea, traditional Chinese medicine granules and preparation method thereof - Google Patents
Pharmaceutical composition for treating piglet diarrhea, traditional Chinese medicine granules and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/38—Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/84—Valerianaceae (Valerian family), e.g. valerian
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention belongs to the field of traditional Chinese veterinary medicines, and particularly relates to a pharmaceutical composition for treating piglet diarrhea, traditional Chinese medicine granules and a preparation method thereof. The pharmaceutical composition mainly comprises the following components: low temperature extract of Hypericum perforatum, low temperature extract of Valeriana jatamansi Jones, and ultrafine powder of Acorus tatarinowii Schott; the dosages of the traditional Chinese medicinal materials including the hypericum perforatum, the valeriana jatamansi jones and the grassleaf sweelflag rhizome are respectively 30-50 parts, 20-50 parts and 10-20 parts by weight; the low temperature extract corresponds to an extraction temperature of not higher than 60 ℃. According to the invention, the targeted differential treatment is carried out according to different traditional Chinese medicinal materials, so that the stability of the effective components is improved, the full exertion of the medicinal properties of the traditional Chinese medicinal materials is ensured, and the prevention and treatment effect of the medicine on piglet diarrhea is further improved.
Description
Technical Field
The invention belongs to the field of traditional Chinese veterinary medicines, and particularly relates to a pharmaceutical composition for treating piglet diarrhea, traditional Chinese medicine granules and a preparation method thereof.
Background
The diarrhea is a common disease of weaned piglets, can be caused by various pathogens, and can cause diarrhea of piglets due to infectious gastroenteritis, swine fever, rotavirus and escherichia coli, and has the clinical manifestations of severe diarrhea, yellow or white loose stool discharge, dehydration, mental depression, cyanosis of skin, high morbidity and mortality, and serious harm.
The prevention and control of the diarrhea of the weaned piglets are based on the principle of 'prevention as the main part, treatment as the auxiliary part and prevention and control combined'. At present, the prevention and treatment of antibiotic drugs are still the main measures for treating piglet diarrhea, and the drug resistance problem of escherichia coli is increasingly prominent along with the research and utilization of antibacterial drugs. However, the important solution of traditional Chinese medicine as a substitute for antibiotics to solve drug resistance and drug residue has been paid more and more attention. The traditional Chinese medicine plays a role in immunoregulation by mainly activating the reticuloendothelial system and complement, activating macrophages and T, B lymphocytes, inducing various cytokines and the like. Meanwhile, the traditional Chinese medicines have the effects of promoting the transfer of water and sodium ions from the intestinal tract to intestinal mucosa epithelial cells, and some traditional Chinese medicines have the effect of inhibiting the movement of small intestines, which all form the important mechanism of the anti-diarrhea effect of the traditional Chinese medicines.
The Chinese patent with application publication number CN106728579A discloses a pharmaceutical composition for treating piglet epidemic diarrhea, which consists of four traditional Chinese medicines of hypericum perforatum, astragalus mongholicus, rhizoma acori graminei and valeriana jatamansi. The cure rate of the medicine composition for treating the piglet diarrhea is about 70-80%, and the prevention and treatment effect on the piglet diarrhea needs to be further improved.
Disclosure of Invention
The invention aims to provide a pharmaceutical composition for treating piglet diarrhea, which can further improve the prevention and treatment effect on piglet diarrhea.
The second purpose of the invention is to provide a traditional Chinese medicine granule for treating piglet diarrhea.
The third purpose of the invention is to provide a preparation method of the traditional Chinese medicine granule.
In order to achieve the purpose, the technical scheme of the pharmaceutical composition for treating piglet diarrhea provided by the invention is as follows:
a pharmaceutical composition for treating piglet diarrhea mainly comprises the following components: low temperature extract of Hypericum perforatum, low temperature extract of Valeriana jatamansi Jones, and ultrafine powder of Acorus tatarinowii Schott; the dosages of the traditional Chinese medicinal materials including the hypericum perforatum, the valeriana jatamansi jones and the grassleaf sweelflag rhizome are respectively 20-60 parts, 20-60 parts and 5-30 parts by weight; the low temperature extract corresponds to an extraction temperature of not higher than 60 ℃.
According to the invention, the targeted differential treatment is carried out according to different traditional Chinese medicinal materials, so that the stability of the effective components is improved, the full exertion of the medicinal properties of the traditional Chinese medicinal materials is ensured, and the prevention and treatment effect of the medicine on piglet diarrhea is further improved.
Preferably, the pharmaceutical composition further comprises cinnamon extract; the dosage of the traditional Chinese medicine cinnamon is not more than 20 parts.
Preferably, the pharmaceutical composition further comprises pomegranate rind extract; the usage amount of the traditional Chinese medicine pomegranate rind is not more than 20 parts.
Preferably, the pharmaceutical composition is prepared from the following Chinese medicinal materials in parts by weight: 20-60 parts of hypericum perforatum, 20-60 parts of valeriana jatamansi jones, 5-30 parts of rhizoma acori graminei, 5-20 parts of cinnamon and 5-20 parts of pomegranate rind. More preferably: 30-50 parts of hypericum perforatum, 20-50 parts of valeriana jatamansi, 10-20 parts of rhizoma acori graminei, 5-20 parts of cinnamon and 5-20 parts of pomegranate rind.
The pharmacological action of each traditional Chinese medicine in the pharmaceutical composition and the consideration of extracting different traditional Chinese medicines are explained as follows:
herba Hyperici perforati: being pungent and cold in property, it enters liver meridian. The functions and indications are as follows: soothing liver and relieving depression, clearing heat and promoting diuresis, which belongs to the heat-clearing and detoxifying drugs. Has hemostatic, antibacterial, antiinflammatory, and antiviral effects.
Valeriana jatamansi jones: slightly bitter, pungent and warm in nature. It enters heart, spleen and stomach meridians. The functions and indications are as follows: regulating qi-flowing, relieving pain, resolving food stagnation, relieving diarrhea, dispelling pathogenic wind and removing dampness, and can be used for treating abdominal distention and pain, dyspepsia, diarrhea, dysentery, and rheumatalgia. Modern medical research proves that the valeriana jatamansi jones extract has good curative effect on gram-positive bacteria and rotavirus enteritis and non-rotavirus enteritis.
The main effective components of herba Hyperici perforati are hyperoside and hypericin. The active ingredients are sensitive to heat, light and the like, and have unstable properties. The antibacterial effective component in Valeriana jatamansi jones is iridoid component, which has unstable property and is easy to undergo hydrolysis, condensation and other reactions.
Aiming at the problems that the effective components in the hypericum perforatum and the valeriana jatamansi jones are sensitive to heat, light and the like and have unstable properties, the invention adopts a low-temperature ultrasonic process to extract medicinal materials to prepare a low-temperature extract. The cryogenic extract is preferably in the form of a lyophilized powder.
Grassleaf sweelflag rhizome: pungent, bitter and warm in nature. It enters heart and stomach meridians. It can be used for treating unconsciousness, epilepsy, diarrhea due to cold-dampness, and abdominal distention. Research proves that the effective component of the grass-leaved sweetflag has obvious inhibiting effect on various pathogenic bacteria and fungi.
The main effective component of the grassleaf sweelflag rhizome which plays an anti-inflammatory role is asarone, belongs to volatile oil and is unstable in property. The inventor finds that the content difference of the effective components in the extracting solution and the concentrated solution is large, and the full exertion of the medicine property is not facilitated. According to the invention, the medicinal materials are crushed by adopting an ultra-micro crushing technology, cell walls are broken, effective components are fully exposed, and the stability of the effective components is improved.
Cinnamon: pungent, sweet and big heat. It enters kidney, spleen, heart and liver meridians. Has effects of nourishing fire, tonifying yang, guiding fire to origin, dispelling cold, relieving pain, and warming and dredging channels and collaterals, and can be used for treating cold pain of heart and abdomen, vomiting and diarrhea due to deficiency cold. And has pharmacological effects of resisting inflammation, resisting diarrhea, resisting gastric ulcer, and regulating immunity. The cinnamaldehyde in cinnamon is the main component of the volatile oil of the cinnamon and belongs to the effective component with the strongest antibacterial activity.
Pomegranate rind: warm in nature and sour and astringent in taste. It enters large intestine meridian. Has effects of astringing intestine to stop bleeding, expelling parasites to stop bleeding, and treating dysentery, enteropathogenic wind diarrhea, metrorrhagia and leukorrhagia, and can be used for treating chronic diarrhea, worm accumulation, and abdominal pain.
The pericarpium Granati contains punicalagin, punicalin and gallic acid as main effective components, wherein punicalagin is unstable in water solution.
In the invention, the alcohol-water solvent is adopted to extract the cinnamon and the pomegranate rind, so that the stability of the active ingredients in the cinnamon and the pomegranate rind is ensured, and the curative effect of the medicament is further enhanced.
The technical scheme of the traditional Chinese medicine granule for treating piglet diarrhea provided by the invention is as follows:
a Chinese medicinal granule for treating diarrhea of piglets is prepared from the above medicinal composition as main material and adjuvant by making into granule.
On the basis of the above main materials, common adjuvants for granule can be added, such as one or more of lactose, sucrose, water soluble starch, anhydrous glucose, silica gel micropowder, microcrystalline cellulose, mannitol, dextrin, etc., and made into granule by conventional method.
The traditional Chinese medicine granule for treating piglet diarrhea provided by the invention has the advantages of high stability of effective components, high content, few impurities, high dissolution speed, rapid action and quick effect, is simple to operate and is easy for mass production. In the formula, all the raw materials are pure traditional Chinese medicines, so that the traditional Chinese medicine composition has no residue and toxic or side effect, and has remarkable economic and social benefits compared with antibiotic treatment.
The technical scheme of the preparation method of the traditional Chinese medicine granule is as follows:
the preparation method of the traditional Chinese medicine granule comprises the following steps:
1) micronizing rhizoma Acori Graminei to obtain superfine powder;
extracting herba Hyperici perforati and radix Pimpinellae Candolleanae with ethanol water at a temperature of not higher than 60 deg.C to obtain low temperature extract;
2) granulating the superfine pulverized material of rhizoma Acori Graminei, low temperature extracts of herba Hyperici perforati and radix Pimpinellae Candolleanae, and adjuvants.
The preparation method of the traditional Chinese medicine granules has high utilization rate of raw materials, reduces the loss of effective components due to instability, and has an important effect of improving the curative effect of the existing veterinary medicine. Meanwhile, the method is simple in preparation process and suitable for large-scale industrial production.
Preferably, in step 1), the temperature of not higher than 60 ℃ is 50 to 60 ℃. The extraction is carried out at the temperature, so that the effective components of the medicine are not decomposed, and the extraction efficiency is higher.
In the step 1), the low-temperature extract is freeze-dried powder prepared by freeze-drying an extracting solution. The freeze-dried powder form is adopted, so that the influence of solvent components such as alcohol, water and the like on the effective components of the medicine can be further avoided, and the stability is improved.
Preferably, in the step 1), the low-temperature extraction is ultrasonic extraction, the medicinal materials are subjected to ultrasonic extraction for multiple times by using an alcohol-water solvent, and the extracting solutions are combined. In this step, the alcohol-water solvent is preferably an aqueous solution of ethanol having a concentration of 50 to 70% by volume. Alcohol-water solvent 6-8 times of the medicinal materials can be added according to the volume ratio. The number of extraction times is preferably 2-3. Soaking for 1-2h before the first ultrasonic extraction.
The power of ultrasonic extraction is 100-150W, the frequency is 60-100kHz, and the extraction time is 10-20min each time. Mixing extractive solutions, centrifuging to remove impurities, concentrating the filtrate at 50-60 deg.C under reduced pressure to volatilize solvent, and freeze drying the concentrated solution to obtain lyophilized powder.
Preferably, the Chinese medicinal materials also comprise cinnamon and/or pomegranate bark, the cinnamon and/or pomegranate bark are heated and refluxed and extracted by using an alcohol-water solvent, and the obtained extracting solution is prepared into extract for use.
When extracting cinnamon and pomegranate rind, the alcohol-water solvent is preferably ethanol water solution with the volume percentage concentration of 10-30%. 6-10 times of alcohol-water solvent can be added according to the volume ratio. The number of extraction times is preferably 2-3. Soaking for 1-2h before the first ultrasonic extraction.
The temperature of the heating reflux extraction is 100 ℃. The time is 1h each time. Mixing filtrates, concentrating under reduced pressure to relative density of 1.20-1.30(60 deg.C), and centrifuging to remove impurities to obtain extract.
Adding superfine powder of rhizoma Acori Graminei and adjuvants into a mixer, mixing with lyophilized powder of herba Hyperici perforati and radix Pimpinellae Candolleanae for 15-30 min, adding cortex Cinnamomi and pericarpium Granati extract (optional), mixing, granulating, drying, and sieving to obtain final product granule.
Detailed Description
The following examples are provided to further illustrate the practice of the invention.
One embodiment of the pharmaceutical composition for treating piglet diarrhea of the invention
Example 1
The pharmaceutical composition for treating piglet diarrhea provided by the embodiment comprises the following traditional Chinese medicinal materials in parts by weight: 50g of hypericum perforatum, 50g of valeriana jatamansi jones and 10g of rhizoma acori graminei; preparing a Chinese medicinal material rhizoma acori graminei into superfine crushed substances; ultrasonic extracting traditional Chinese medicinal materials including herba Hyperici perforati and Valeriana jatamansi jones with alcohol-water solvent at 50 deg.C to obtain low temperature extract, wherein the low temperature extract is lyophilized powder, and the alcohol-water solvent is 50% ethanol water solution.
Example 2
The pharmaceutical composition for treating piglet diarrhea provided by the embodiment comprises the following traditional Chinese medicinal materials in parts by weight: 50g of hypericum perforatum, 30g of valeriana jatamansi, 10g of rhizoma acori graminei and 10g of cinnamon; preparing a Chinese medicinal material rhizoma acori graminei into superfine crushed substances; ultrasonic extracting traditional Chinese medicinal materials including herba Hyperici perforati and Valeriana jatamansi jones with alcohol-water solvent at 50 deg.C to obtain low temperature extract, wherein the low temperature extract is lyophilized powder, and the alcohol-water solvent is 60% ethanol water solution; the traditional Chinese medicine cinnamon is heated and refluxed and extracted by adopting an alcohol-water solvent, the extract is in the form of an extract, and the alcohol-water solvent is an ethanol water solution with the volume percentage concentration of 10%.
Example 3
The pharmaceutical composition for treating piglet diarrhea provided by the embodiment comprises the following traditional Chinese medicinal materials in parts by weight: 30g of hypericum perforatum, 30g of valeriana jatamansi, 20g of rhizoma acori graminei and 20g of pomegranate rind; ultrasonic extracting traditional Chinese medicinal materials including herba Hyperici perforati and Valeriana jatamansi jones with alcohol-water solvent at 60 deg.C to obtain low temperature extract, wherein the low temperature extract is lyophilized powder, and the alcohol-water solvent is 50% ethanol water solution; the traditional Chinese medicine pomegranate rind is heated and refluxed and extracted by adopting an alcohol-water solvent, the extract is in the form of an extract, and the alcohol-water solvent is an ethanol water solution with the volume percentage concentration of 10%.
Example 4
The pharmaceutical composition for treating piglet diarrhea provided by the embodiment comprises the following traditional Chinese medicinal materials in parts by weight: 30g of hypericum perforatum, 20g of valeriana jatamansi jones, 20g of rhizoma acori graminei, 20g of cinnamon and 20g of pomegranate rind; ultrasonic extracting traditional Chinese medicinal materials including herba Hyperici perforati and Valeriana jatamansi jones with alcohol-water solvent at 50 deg.C to obtain low temperature extract, wherein the low temperature extract is lyophilized powder, and the alcohol-water solvent is 50% ethanol water solution; the traditional Chinese medicinal materials cinnamon and pomegranate rind are heated and refluxed and extracted by adopting an alcohol-water solvent, the extract is in the form of an extract, and the alcohol-water solvent is an ethanol water solution with the volume percentage concentration of 10%.
Example 5
The pharmaceutical composition for treating piglet diarrhea provided by the embodiment comprises the following traditional Chinese medicinal materials in parts by weight: 40g of hypericum perforatum, 30g of valeriana jatamansi, 10g of rhizoma acori graminei, 15g of cinnamon and 15g of pomegranate rind; ultrasonic extracting traditional Chinese medicinal materials including herba Hyperici perforati and Valeriana jatamansi jones with alcohol-water solvent at 55 deg.C to obtain low temperature extract, wherein the low temperature extract is lyophilized powder, and the alcohol-water solvent is 60% ethanol water solution; the traditional Chinese medicinal materials cinnamon and pomegranate rind are heated and refluxed and extracted by adopting an alcohol-water solvent, wherein the extract is in the form of an extract, and the alcohol-water solvent is an ethanol water solution with the volume percentage concentration of 20%.
Example 6
The pharmaceutical composition for treating piglet diarrhea provided by the embodiment comprises the following traditional Chinese medicinal materials in parts by weight: 50g of hypericum perforatum, 40g of valeriana jatamansi, 10g of rhizoma acori graminei, 5g of cinnamon and 5g of pomegranate rind; ultrasonic extracting traditional Chinese medicinal materials including herba Hyperici perforati and Valeriana jatamansi jones with alcohol-water solvent at 60 deg.C to obtain low temperature extract, wherein the low temperature extract is lyophilized powder, and the alcohol-water solvent is 70% ethanol water solution; the traditional Chinese medicinal materials cinnamon and pomegranate rind are heated and refluxed and extracted by adopting an alcohol-water solvent, wherein the extract is in the form of an extract, and the alcohol-water solvent is an ethanol water solution with the volume percentage concentration of 30%.
Second, the specific embodiment of the traditional Chinese medicine granule for treating piglet diarrhea of the invention
Example 7
The traditional Chinese medicine granule for treating piglet diarrhea is prepared from main materials and auxiliary materials into granules. Wherein the main material is the pharmaceutical composition of example 1, comprising superfine powder of rhizoma Acori Graminei, lyophilized powder of herba Hyperici perforati and radix Pimpinellae Candolleanae; the auxiliary materials comprise the following components in parts by weight: 20 parts of lactose, 10 parts of microcrystalline cellulose and 30 parts of mannitol.
Example 8
The traditional Chinese medicine granule for treating piglet diarrhea is prepared from main materials and auxiliary materials. Wherein the main material is the pharmaceutical composition in the embodiment 2, which comprises superfine powder of rhizoma acori graminei, hypericum perforatum, freeze-dried powder of valeriana jatamansi jones and cinnamon extract; the auxiliary materials comprise the following components in parts by weight: 10 parts of lactose, 40 parts of water-soluble starch and 10 parts of superfine silica gel powder.
Example 9
The traditional Chinese medicine granule for treating piglet diarrhea is prepared from main materials and auxiliary materials. Wherein the main material is the pharmaceutical composition in the embodiment 3, which comprises superfine powder of rhizoma acori graminei, freeze-dried powder of hypericum perforatum and valeriana jatamansi jones and pomegranate bark extract; the auxiliary materials comprise the following components in parts by weight: 35 parts of cane sugar and 15 parts of dextrin.
Example 10
The traditional Chinese medicine granule for treating piglet diarrhea is prepared from main materials and auxiliary materials. Wherein the main material is the pharmaceutical composition of embodiment 4, comprising superfine powder of rhizoma acori graminei, freeze-dried powder of hypericum perforatum and valeriana jatamansi jones, and extract of cortex cinnamomi and pericarpium granati; the auxiliary materials comprise the following components in parts by weight: 35 parts of lactose and 25 parts of mannitol.
Example 11
The traditional Chinese medicine granule for treating piglet diarrhea is prepared from main materials and auxiliary materials. Wherein the main material is the pharmaceutical composition of embodiment 5, comprising superfine powder of rhizoma acori graminei, freeze-dried powder of hypericum perforatum and valeriana jatamansi jones, and extract of cortex cinnamomi and pericarpium granati; the auxiliary materials comprise the following components in parts by weight: 40 parts of anhydrous glucose, 10 parts of dextrin and 10 parts of superfine silica gel powder.
Example 12
The traditional Chinese medicine granule for treating piglet diarrhea is prepared from main materials and auxiliary materials. Wherein the main material is the pharmaceutical composition of embodiment 6, comprising superfine powder of rhizoma acori graminei, freeze-dried powder of hypericum perforatum and valeriana jatamansi jones, and extract of cortex cinnamomi and pericarpium granati; the auxiliary materials comprise the following components in parts by weight: 30 parts of water-soluble starch, 15 parts of microcrystalline cellulose and 15 parts of dextrin.
Third, the specific embodiment of the preparation method of the traditional Chinese medicine granule for treating piglet diarrhea of the present invention
Example 13
The preparation method of the traditional Chinese medicine granule for treating piglet diarrhea in this embodiment describes the synthesis process of the traditional Chinese medicine granule for treating piglet diarrhea in embodiment 7, and comprises the following steps:
(1) the traditional Chinese medicine is pretreated by sieving, washing and other modes to remove soil and foreign matters in the traditional Chinese medicine.
(2) Classifying and processing the traditional Chinese medicinal materials:
firstly, crushing the grassleaf sweelflag rhizome by using an ultrafine crusher, and sieving the grass leaf sweelflag rhizome by using a 120-mesh sieve to obtain the grassleaf sweelflag rhizome ultrafine powder;
② weighing the hypericum perforatum and valeriana jatamansi jones according to the formula amount, carrying out ultrasonic extraction for three times at 50 ℃ by using 50% ethanol solution, wherein the extraction time is 10min, the ultrasonic power is 120W, the frequency is 70kHz, the volume of the ethanol solution added in the three-time extraction is respectively 7 times, 7 times and 6 times of the amount of the medicinal materials, and soaking the medicinal materials for 1h in the first extraction. After extraction is finished, combining the three extracting solutions, sequentially carrying out centrifugation and impurity removal, vacuum concentration at 55 ℃, and freeze drying to obtain the hypericum perforatum and valeriana jatamansi freeze-dried powder.
(3) Accurately weighing the extracted superfine powder of the grassleaf sweelflag rhizome, the hypericum perforatum, the freeze-dried powder of the valeriana jatamansi jones and the auxiliary materials of 20 parts of lactose, 10 parts of microcrystalline cellulose and 30 parts of mannitol, putting into a mixer, mixing for 15min to prepare a soft material, preparing the obtained soft material into wet granules by using a 14-mesh sieve, further placing the wet granules into a reduced-pressure drying oven, drying for 2h at 50 ℃, and finally sieving the dried granules by using the 14-mesh sieve to obtain finished granules.
Example 14
The embodiment is a preparation method of traditional Chinese medicine granules for treating piglet diarrhea, and the synthesis process of the traditional Chinese medicine granules for treating piglet diarrhea in the embodiment 8 is described, which comprises the following steps:
(1) the traditional Chinese medicine is pretreated by sieving, washing and other modes to remove soil and foreign matters in the traditional Chinese medicine.
(2) Classifying and processing the traditional Chinese medicinal materials:
firstly, crushing the grass-leaved sweetflag by using an ultrafine crusher, and sieving the grass-leaved sweetflag by using a 150-mesh sieve to obtain the ultrafine grass-leaved sweetflag powder;
② weighing the hypericum perforatum and valeriana jatamansi jones according to the formula amount, carrying out ultrasonic extraction for three times at 50 ℃ by using 60% ethanol solution, wherein each extraction time is 10min, the ultrasonic power is 130W, the ultrasonic frequency is 60kHz, the volumes of the ethanol solution added in the three-time extraction are respectively 8 times, 6 times and 6 times of the amount of the medicinal materials, and soaking the medicinal materials for 1.5h in the first extraction. After extraction is finished, combining the three extracting solutions, sequentially carrying out centrifugation and impurity removal, decompression and concentration at 50 ℃, and freeze drying to obtain the hypericum perforatum and valeriana jatamansi freeze-dried powder.
Weighing the cinnamon with the formula amount, adding a 10% ethanol solution, carrying out heating reflux extraction at 100 ℃, carrying out extraction for three times, wherein the extraction time is 1h, the volumes of the added ethanol solution are respectively 8 times, 6 times and 6 times of the volume of the cinnamon, and soaking the medicinal materials for 2h in the first extraction. After extraction is finished, combining the three extracting solutions, and sequentially carrying out centrifugation, impurity removal and reduced pressure concentration to obtain the cinnamon extract with the relative density of 1.20-1.30(60 ℃).
(3) Accurately weighing the extracted superfine powder of the grassleaf sweelflag rhizome, the hypericum perforatum, the freeze-dried powder of the valeriana jatamansi jones and 10 parts of lactose, 40 parts of water-soluble starch and 10 parts of superfine silica gel powder as auxiliary materials, putting the mixture into a mixer, mixing for 20min, adding the cinnamon extract, stirring for 35min, mixing to prepare a soft material, sieving the obtained soft material with a 14-mesh sieve to prepare wet granules, further placing the wet granules into a reduced-pressure drying oven, drying for 2h at 50 ℃, and finally sieving the dried granules with the 14-mesh sieve to obtain finished granules.
Example 15
The present embodiment is a preparation method of a traditional Chinese medicine granule for treating piglet diarrhea, and describes a synthesis process of the traditional Chinese medicine granule for treating piglet diarrhea in example 9, which includes the following steps:
(1) the traditional Chinese medicine is pretreated by sieving, washing and other modes to remove soil and foreign matters in the traditional Chinese medicine.
(2) Classifying and processing the traditional Chinese medicinal materials:
firstly, crushing the grass-leaved sweetflag by using an ultrafine crusher, and sieving the grass-leaved sweetflag by using a 200-mesh sieve to obtain the ultrafine grass-leaved sweetflag powder;
② weighing the hypericum perforatum and the valeriana jatamansi jones according to the formula ratio, and ultrasonically extracting for three times at 60 ℃ by using 50 percent ethanol solution, wherein each extraction time is 10min, the ultrasonic power is 110W, and the ultrasonic frequency is 90 kHz. The volumes of the ethanol solutions added for three times are respectively 8 times, 6 times and 6 times of the amount of the medicinal materials, and the medicinal materials are soaked for 1.5 hours during the first extraction. After extraction is finished, combining the three extracting solutions, sequentially carrying out centrifugation and impurity removal, decompression and concentration at 60 ℃, and freeze drying to obtain the hypericum perforatum and valeriana jatamansi freeze-dried powder.
Weighing the pomegranate rind according to the formula ratio, adding 10% ethanol solution, carrying out heating reflux extraction at 100 ℃, carrying out extraction for three times, wherein the extraction time is 1h, the volumes of the added ethanol solution are 10 times, 8 times and 8 times of the volume of the pomegranate rind respectively, and soaking the medicinal materials for 2h during the first extraction. After extraction, combining the three extracting solutions, and sequentially carrying out centrifugation, impurity removal and reduced pressure concentration to obtain the pomegranate bark extract with the relative density of 1.20-1.30(60 ℃).
(3) Accurately weighing the extracted superfine powder of the grassleaf sweelflag rhizome, the hypericum perforatum, the spider aroma freeze-dried powder and the auxiliary materials of 35 parts of cane sugar and 15 parts of dextrin, putting the materials into a mixer for mixing for 15min, adding the pomegranate rind extract, stirring for 30min, mixing to prepare a soft material, preparing the obtained soft material into wet granules by using a 14-mesh sieve, further placing the wet granules into a reduced-pressure drying oven, drying for 2h at 50 ℃, and finally sieving the dried granules by using the 14-mesh sieve to obtain finished granules.
Example 16
The present embodiment is a preparation method of a traditional Chinese medicine granule for treating piglet diarrhea, and describes a synthesis process of the traditional Chinese medicine granule for treating piglet diarrhea in embodiment 10, which includes the following steps:
(1) the traditional Chinese medicine is pretreated by sieving, washing and other modes to remove soil and foreign matters in the traditional Chinese medicine.
(2) Classifying and processing the traditional Chinese medicinal materials:
firstly, crushing the grassleaf sweelflag rhizome by using an ultrafine crusher, and sieving the grass leaf sweelflag rhizome by using a 120-mesh sieve to obtain the grassleaf sweelflag rhizome ultrafine powder;
② weighing the hypericum perforatum and the valeriana jatamansi jones according to the formula ratio, and ultrasonically extracting for three times at 50 ℃ by using 50 percent ethanol solution, wherein each extraction time is 10min, the ultrasonic power is 140W, and the ultrasonic frequency is 60 kHz. The volumes of the ethanol solutions added for three times are respectively 8 times, 6 times and 6 times of the amount of the medicinal materials, and the medicinal materials are soaked for 2 hours during the first extraction. After extraction is finished, combining the three extracting solutions, sequentially carrying out centrifugation and impurity removal, decompression and concentration at 50 ℃, and freeze drying to obtain the hypericum perforatum and valeriana jatamansi freeze-dried powder.
Weighing the cinnamon and the pomegranate rind according to the formula ratio, adding a 10% ethanol solution, heating and refluxing for extraction at 100 ℃, carrying out extraction for three times, wherein the volume of the added ethanol solution is 10 times, 8 times and 8 times of the volume of the pomegranate rind and the volume of the cinnamon, and soaking the medicinal materials for 1 hour during first extraction. After extraction, combining the three extracting solutions, and sequentially performing centrifugation, impurity removal and reduced pressure concentration to obtain cinnamon and pomegranate bark extractum with the relative density of 1.20-1.30(60 ℃).
(3) Accurately weighing the extracted superfine powder of the grassleaf sweelflag rhizome, the hypericum perforatum, the freeze-dried powder of the valeriana jatamansi jones and the auxiliary materials of 35 parts of lactose and 25 parts of mannitol, putting into a mixer, mixing for 15min, adding the pomegranate rind and the cinnamon extract, stirring for 40min, mixing to prepare a soft material, preparing the obtained soft material into wet granules by using a 14-mesh sieve, further placing the wet granules into a reduced-pressure drying oven, drying for 2h at 50 ℃, and finally sieving the dried granules by using the 14-mesh sieve to obtain finished granules.
Example 17
The present embodiment is a preparation method of a traditional Chinese medicine granule for treating diarrhea of piglets, and describes a synthesis process of the traditional Chinese medicine granule for treating diarrhea of piglets in example 11, and the method comprises the following steps:
(1) the traditional Chinese medicine is pretreated by sieving, washing and other modes to remove soil and foreign matters in the traditional Chinese medicine.
(2) Classifying and processing the traditional Chinese medicinal materials:
firstly, crushing the grass-leaved sweetflag by using an ultrafine crusher, and sieving the grass-leaved sweetflag by using a 150-mesh sieve to obtain the ultrafine grass-leaved sweetflag powder;
② weighing the hypericum perforatum and the valeriana jatamansi jones according to the formula ratio, and ultrasonically extracting for three times at 55 ℃ by using 60 percent ethanol solution, wherein each extraction time is 15min, the ultrasonic power is 100W, and the ultrasonic frequency is 100 kHz. The volumes of the ethanol solutions added for three times are respectively 8 times, 6 times and 6 times of the amount of the medicinal materials, and the medicinal materials are soaked for 2 hours during the first extraction. After extraction is finished, combining the three extracting solutions, sequentially carrying out centrifugation and impurity removal, decompression and concentration at 50 ℃, and freeze drying to obtain the hypericum perforatum and valeriana jatamansi freeze-dried powder.
Weighing the cinnamon and the pomegranate rind according to the formula ratio, adding 20% ethanol solution, heating and refluxing for extraction at 100 ℃, carrying out extraction for three times, wherein the volume of the added ethanol solution is 10 times, 8 times and 8 times of that of the pomegranate rind and the cinnamon respectively, and soaking the medicinal materials for 1 hour during first extraction. After extraction, combining the three extracting solutions, and sequentially performing centrifugation, impurity removal and reduced pressure concentration to obtain cinnamon and pomegranate bark extractum with the relative density of 1.20-1.30(60 ℃).
(3) Accurately weighing the extracted superfine powder of the grassleaf sweelflag rhizome, the hypericum perforatum, the spider aroma freeze-dried powder and the auxiliary materials 40 parts of anhydrous glucose, 10 parts of dextrin and 10 parts of superfine silica gel powder, putting the mixture into a mixer, mixing for 20min, adding the pomegranate rind and the cinnamon extract, stirring for 30min, mixing to prepare a soft material, preparing the obtained soft material into wet granules by using a 14-mesh sieve, further placing the wet granules into a reduced-pressure drying oven, drying for 2h at 50 ℃, and finally sieving the dried granules by using the 14-mesh sieve to obtain finished granules.
Example 18
The present embodiment is a preparation method of a traditional Chinese medicine granule for treating piglet diarrhea, and describes a synthesis process of the traditional Chinese medicine granule for treating piglet diarrhea in example 12, which includes the following steps:
(1) the traditional Chinese medicine is pretreated by sieving, washing and other modes to remove soil and foreign matters in the traditional Chinese medicine.
(2) Classifying and processing the traditional Chinese medicinal materials:
firstly, crushing the grass-leaved sweetflag by using an ultrafine crusher, and sieving the grass-leaved sweetflag by using a 200-mesh sieve to obtain the ultrafine grass-leaved sweetflag powder; ② weighing the hypericum perforatum and the valeriana jatamansi jones according to the formula ratio, and carrying out ultrasonic extraction for three times at 60 ℃ by using 70 percent ethanol solution, wherein each extraction time is 15min, the ultrasonic power is 125W, and the ultrasonic frequency is 75 kHz. The volumes of the ethanol solutions added for three times are respectively 8 times, 6 times and 6 times of the amount of the medicinal materials, and the medicinal materials are soaked for 2 hours during the first extraction. After extraction is finished, combining the three extracting solutions, sequentially carrying out centrifugation and impurity removal, decompression and concentration at 60 ℃, and freeze drying to obtain the hypericum perforatum and valeriana jatamansi freeze-dried powder.
Weighing the cinnamon and the pomegranate rind according to the formula ratio, adding 30% ethanol solution, heating and refluxing for extraction at 100 ℃, carrying out extraction for three times, wherein the volume of the added ethanol solution is 10 times, 8 times and 8 times of that of the pomegranate rind and the cinnamon respectively, and soaking the medicinal materials for 1 hour during first extraction. After extraction, combining the three extracting solutions, and sequentially performing centrifugation, impurity removal and reduced pressure concentration to obtain cinnamon and pomegranate bark extractum with the relative density of 1.20-1.30(60 ℃).
(3) Accurately weighing the extracted superfine powder of the grassleaf sweelflag rhizome, the hypericum perforatum, the freeze-dried powder of the valeriana jatamansi jones and the auxiliary materials of 30 parts of water-soluble starch, 15 parts of microcrystalline cellulose and 15 parts of dextrin, putting the mixture into a mixer, mixing for 30min, adding the pomegranate rind and the cinnamon extract, stirring for 50min, mixing to prepare a soft material, preparing the obtained soft material into wet granules by using a 14-mesh sieve, further placing the wet granules into a reduced-pressure drying oven, drying for 2h at 50 ℃, and finally sieving the dried granules by using the 14-mesh sieve to obtain finished granules.
Fourth, example of experiment
Experimental example 1
The experimental example evaluates the difference of the extraction effects of different extraction methods. Evaluating the extraction effects of different extraction methods of the rhizoma acori graminei by taking the extraction rate of the volatile oil as an evaluation index; the extraction efficiency of hyperin was used as an evaluation index to evaluate the extraction effect of different extraction methods of hyperin, and the results are shown in tables 1-2.
Wherein, the comparative example 1 refers to the prior art of CN106728579A, and the volatile oil in the rhizoma acori graminei is extracted by a distillation method. Wherein, the extraction rate (%) of the volatile oil is equal to the mass of the volatile oil/the mass of the traditional Chinese medicinal materials multiplied by 100.
TABLE 1 extraction effect of different extraction methods of Acorus gramineus soland
| Example name | Extraction rate of effective components-extraction rate of volatile oil |
| Example 1 | 0.67％ |
| Comparative example 1 distillation method | 0.47％ |
As can be seen from Table 1, the method of the example is more advantageous in the extraction of volatile oil from Acorus gramineus soland.
Furthermore, the invention researches another common extraction mode of the effective components of the rhizoma acori graminei, and concretely, the rhizoma acori graminei and petroleum ether are mixed and extracted at the temperature of 60 ℃ to obtain the rhizoma acori graminei extracting solution; and (4) performing reduced pressure rotary evaporation to obtain a rhizoma acori graminei concentrated solution. Similarly, the volatile oil of rhizoma Acori Graminei is used as effective component, the content of effective component in rhizoma Acori Graminei extractive solution is 5.43 + -0.22 (ml/100g), and the content of effective component in rhizoma Acori Graminei concentrated solution is 0.45 + -0.34 (ml/100 g).
In the common dosage forms, the rhizoma acori graminei extract cannot be directly used, and is prepared into the rhizoma acori graminei concentrated solution through concentration, but after concentration, the loss of active ingredients is large, and the drug effect is also greatly influenced, namely the extraction-concentration form of the rhizoma acori graminei is not suitable for practical application.
In table 2, comparative example 2 refers to CN106728579A in the prior art, and extraction is performed by a heating reflux extraction method. Wherein, the extraction rate (%) of hyperoside is equal to the amount of hyperoside in the extract/amount of hyperoside in the raw medicinal material x 100.
TABLE 2 extraction Effect of different extraction methods of Hypericum perforatum
| Example name | Extraction rate of effective components-hyperin extraction rate |
| Example 1 | 85％ |
| Comparative example 2 heating reflux extraction method | 71％ |
As can be seen from tables 1 and 2, the methods of the examples have advantages in the extraction of volatile oil from acorus gramineus and the extraction of hyperin, thereby creating good conditions for further improving the drug effect.
Experimental example 2
The experimental example is a clinical test of the traditional Chinese medicine granules for treating piglet diarrhea, and the specific experimental process is as follows:
the usage and dosage are as follows: the administration was carried out in a batch of 0.25g/kg.w body weight for 3 consecutive days.
Test animals: 200 pigs which are confirmed to be diarrhea of piglets in a certain pig farm of Hebei Handan are randomly selected from the pig herd which is diagnosed as diarrhea of piglets according to clinical symptoms and epidemiology, and are divided into 8 groups.
Test drugs: the Chinese medicinal granules prepared in examples 13 to 18 were used in the test groups 1 to 6 in sequence for 3 days, and the blank control group was not administered. The drug control group has the same dosage as the traditional Chinese medicinal materials in example 13, and is different from the traditional Chinese medicinal materials in extraction modes, according to the method recorded in the prior art CN106728579A, the rhizoma acori graminei adopts a distillation method to extract volatile oil and is included by cyclodextrin; the herba Hyperici perforati and radix Pimpinellae Candolleanae are extracted by heating and refluxing, and then made into lyophilized powder in the same way.
The test method comprises the following steps: the medicines are used for 3 days together, the number of cure, death, invalidation and improvement after 3 days of use is observed and counted, the total effective rate is calculated, and the test result is shown in table 3.
And (3) curing: the diarrhea and diarrhea clinical symptoms disappear, and the feces, the ingestion and the mental status are recovered to be normal.
Improvement: diarrhea and diarrhea symptoms of sick pigs are reduced but not completely recovered to normal.
And (4) invalidation: clinical symptoms did not improve, improved or even worsened, including death.
Death: losing vital signs.
TABLE 3 therapeutic effect of the Chinese medicinal granule for treating diarrhea of piglets
As can be seen from Table 3, the total effective rate of the test groups 1-6 reaches more than 88% after the drug is taken for 3 days, which is significantly higher than that of the blank control group and the drug control group. The results show that the invention has definite curative effect and high cure rate.
Claims (10)
1. A pharmaceutical composition for treating piglet diarrhea is characterized by mainly comprising the following components: low temperature extract of Hypericum perforatum, low temperature extract of Valeriana jatamansi Jones, and ultrafine powder of Acorus tatarinowii Schott; the dosages of the traditional Chinese medicinal materials including the hypericum perforatum, the valeriana jatamansi jones and the grassleaf sweelflag rhizome are respectively 20-60 parts, 20-60 parts and 5-30 parts by weight; the low temperature extract corresponds to an extraction temperature of not higher than 60 ℃.
2. The pharmaceutical composition for treating diarrhea in piglets according to claim 1, further comprising cinnamon extract; the dosage of the traditional Chinese medicine cinnamon is not more than 20 parts.
3. The pharmaceutical composition for treating diarrhea in piglets according to claim 1 or 2, further comprising pomegranate rind extract; the usage amount of the traditional Chinese medicine pomegranate rind is not more than 20 parts.
4. The pharmaceutical composition for treating piglet diarrhea according to claim 1 or 2, which is prepared from the following Chinese medicinal materials in parts by weight: 20-60 parts of hypericum perforatum, 20-60 parts of valeriana jatamansi jones, 5-30 parts of rhizoma acori graminei, 5-20 parts of cinnamon and 5-20 parts of pomegranate rind.
5. A traditional Chinese medicine granule for treating piglet diarrhea, which is characterized in that the medicine composition of any one of claims 1 to 4 is used as a main material and is prepared into granules with auxiliary materials.
6. A method for preparing the traditional Chinese medicine granule as claimed in claim 5, comprising the following steps:
1) micronizing rhizoma Acori Graminei to obtain superfine powder;
extracting herba Hyperici perforati and radix Pimpinellae Candolleanae with ethanol water at a temperature of not higher than 60 deg.C to obtain low temperature extract;
2) granulating the superfine pulverized material of rhizoma Acori Graminei, low temperature extracts of herba Hyperici perforati and radix Pimpinellae Candolleanae, and adjuvants.
7. The method for preparing traditional Chinese medicine granules according to claim 6, wherein in the step 1), the temperature of not higher than 60 ℃ is 50-60 ℃.
8. The method for preparing traditional Chinese medicine granules according to claim 6, wherein in the step 1), the low-temperature extract is lyophilized powder prepared by lyophilizing the extract.
9. The method for preparing Chinese medicinal granules according to any one of claims 6 to 8, wherein in step 1), the low-temperature extraction is ultrasonic extraction, the medicinal materials are subjected to ultrasonic extraction for multiple times by using an alcohol-water solvent, and the extracting solutions are combined.
10. The method for preparing a Chinese medicinal granule according to claim 6, wherein the Chinese medicinal material further comprises cinnamon and/or pomegranate rind, the cinnamon and/or pomegranate rind are/is extracted by heating and refluxing with an alcohol-water solvent, and the obtained extract is used after being made into an extract.
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