CN101284107B - Medicine for curing cancers and preparation method thereof - Google Patents
Medicine for curing cancers and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a pharmaceutical for treating cancer and a preparation method thereof. The pharmaceutical is prepared from taxus, reed root, shinyleaf pricklyash root, cicada slough, medicinai changium root, manyprickle acathopanax root, isatis leaves, polygala root, umbrella polyporus, hirtellous clover-shrub root, tortoise shell, poria, snakegourd fruit, alpine yarrow herb, common portulaca, arisaema tuber, zedoary turmeric rhizome, spatholobus stem, natural indigo, self-heal, long-noded pit viper, rhubarb, subprostrate soplhor root, dandelion, polyphylla, kosam seed, wild glossy ganoderma, centipede, giant knotweed, airpotato yam, Sichuan clematis stem, sun spurge, ricepaper plant pith, medlar, largehead atractylodes rhizome, garden burnet root, schisandra fruit, oldenlandia,daxie, pilose asiabell root, grassleaved sweetflag, lycoris, ledebouriella root, brown lily and TAXEL by mixing proportionally. The pharmaceutical can be used for treating various cancers, especially for treating advanced cancers such as leukaemia with high leucocyte content and cancer metastasis to bones.
Description
Technical field
The present invention relates to a kind of curing cancer drug and preparation method thereof.
Background technology
This disease of cancer is a great problem for the treatment of in the world at present.Because still there is not cure method accurately, every year is approximately died from the patient of cancer about 6,300,000 people in the whole world at present, only the U.S., Europe, Japan are annual just about 4,000,000 people, and ten thousand people die from various carninomatosis among extreme pain surplus China annual 70, and the gesture of growth in addition.Thereby for the generation and the development of anti-curing cancers, many knowledgeable people take a lot of trouble and efforts, the method that all in food and Chinese and western drugs, seeks treatment, but it is little to produce effects, and the Therapeutic Method that has can only temporarily can earn a bare living.For a long time, no matter be the traditional Chinese medical science or doctor trained in Western medicine, all be to take " killing method " treatment cancer mostly, as: the treating the poisonous disease with poisonous drugs that the traditional Chinese medical science is taked etc. is controlled cancer, doctor trained in Western medicine is that cancer is controlled in radiotherapy, chemotherapy and the photoelectricity treatment etc. taked, when the result is kill cancer cell, also damages the human normal cell, thereby heavy damage human normal cell breeding, destruction function of immune system biochemistry destroys human body yin-yang balancing, destroys digestive system and runs well and hemopoietic function.
Summary of the invention
One of purpose of the present invention provides a kind of novel specially good effect curing cancer drug, and following each crude drug of its selection of curing cancer drug of the present invention carries out formulated in combination and forms, and it all has better curative effect in the following weight parts scope:
10～20 parts of Ramulus et folium taxi cuspidataes, 10～30 parts of Rhizoma Phragmitiss, 3～8 parts of Periostracum Cicadaes, 10～20 parts of Radix Zanthoxylis, 5～15 parts of changii,radixs, 20～30 parts of thorn bent sticks, 5～15 parts of Folium Isatidis, 3～5 parts of Radix Polygalaes, 5～15 parts of Polyporus, 3～8 parts of Radix Campylotropis Hirtella (Herba Myrsines Africanae)s, 10～20 parts of Carapax Et Plastrum Testudiniss, 10～15 parts in Poria, 5～15 parts of Fructus Trichosanthis, 5～10 parts of Herba Achilleaes, 20～30 parts of Herba Portulacae Grandifloraes, 5～10 parts of Rhizoma Arisaematiss, 5～10 parts of Rhizoma Curcumae, 5～15 parts of Caulis Spatholobis, 3～8 parts of Indigo Naturaliss, 5～15 parts of Spica Prunellaes, 3～8 parts of Agkistrodons, 10～20 parts of Radix Et Rhizoma Rhei, 3～8 parts of Radix Sophorae Tonkinensiss, 5～15 parts of Herba Taraxacis, 10～30 parts of Rhizoma Paridis, 3～8 parts of Fructus Bruceaes, 20～40 parts of Wild Ganoderma, 3～8 parts of Scolopendras, 3～8 parts of Rhizoma Polygoni Cuspidati, 5～15 parts of Rhizoma Dioscoreae Bulbiferaes, 10～20 parts of Caulis Akebiaes, 3～8 parts of Herba Euphorbiae Helioscopiae, 5～10 parts of Medulla Tetrapanaciss, 10～30 parts of Fructus Lyciis, 10～30 parts of the Rhizoma Atractylodis Macrocephalaes, 20～40 parts in mountain region melon, 3～8 parts of Fructus Schisandrae Chinensis, 40～60 parts of Herba Hedyotidis Diffusaes, 5～15 parts of Herba Dendrobiis, 20～40 parts of Radix Codonopsis, 10～25 parts of Rhizoma Acori Graminei, 10～25 parts of Bulbus Lycoridis Radiataes, 5～15 parts of Radix Saposhnikoviaes, 20～40 parts of Herba Crotalariae sessilifloraes, 1～3 part of paclitaxel.
Two of purpose of the present invention provides above-mentioned curing cancer drug preparation method, and curing cancer drug preparation method of the present invention is: each above-mentioned crude drug is cleaned, and airing, standby after earlier Periostracum Cicadae, Carapax Et Plastrum Testudinis, Agkistrodon, Scolopendra, Ramulus et folium taxi cuspidatae and paclitaxel being pulverized; 39 kinds of crude drug of all the other that again will be above-mentioned mix the back to be carried three times with decocting in water, and each 30～60 minutes, concentrated extracting solution got extractum, dry then, pulverize, and gets curing cancer drug of the present invention after Periostracum Cicadae, Carapax Et Plastrum Testudinis, Agkistrodon, Scolopendra, Ramulus et folium taxi cuspidatae and paclitaxel powder mix.
Curing cancer drug of the present invention is mainly according to " suppress, domestication, transform, repair " anticancer mechanism of uniqueness, use the anticarcinogen that prepared from traditional Chinese medicines becomes, reach the curative effect of more satisfactory above-mentioned all kinds of cancers of healing through clinical application for many years, and under painful, the unsafe situation of cancer patient, cure and do not recur.The present invention has unique cancer cancer therapy drug mechanism of controlling: it can combine with trace protein, and promote its polymerization, the mitosis of anticancer, the propagation that effectively stops cancerous cell, and have domestication and transform to repair cancerous cell, remove carcinogen effect in the body, thus the limit interferences propagation of cancer cells.This curing cancer drug can be controlled all kinds of cancers, and to the high leukemia of leukocyte and to be transferred to all kinds of middle and terminal cancer effects of skeleton obvious, through tens of skies the cancerous protuberance piece is disappeared, cure above-mentioned all kinds of cancers in 1 year, cancer patient rehabilitation under no pain, fast, efficient, safe situation is cured.
The specific embodiment
The present invention is further described (but not being limitation of the present invention) below in conjunction with specific embodiment.
Embodiment 1
Curing cancer drug of the present invention is got following weight portion crude drug and is carried out formulated: 10 parts of Ramulus et folium taxi cuspidataes, 30 parts of Rhizoma Phragmitiss, 5 parts of Periostracum Cicadaes, 10 parts of Radix Zanthoxylis, 15 parts of changii,radixs, 30 parts of thorn bent sticks, 15 parts of Folium Isatidis, 5 parts of Radix Polygalaes, 10 parts of Polyporus, 5 parts of Radix Campylotropis Hirtella (Herba Myrsines Africanae)s, 20 parts of Carapax Et Plastrum Testudiniss, 15 parts in Poria, 15 parts of Fructus Trichosanthis, 10 parts of Herba Achilleaes, 30 parts of Herba Portulacae Grandifloraes, 9 parts of Rhizoma Arisaematiss, 10 parts of Rhizoma Curcumae, 15 parts of Caulis Spatholobis, 3 parts of Indigo Naturaliss, 15 parts of Spica Prunellaes, 5 parts of Agkistrodons, 20 parts of Radix Et Rhizoma Rhei, 5 parts of Radix Sophorae Tonkinensiss, 10 parts of Herba Taraxacis, 10 parts of Rhizoma Paridis, 3 parts of Fructus Bruceaes, 40 parts of Wild Ganoderma, 3 parts of Scolopendras, 5 parts of Rhizoma Polygoni Cuspidati, 10 parts of Rhizoma Dioscoreae Bulbiferaes, 20 parts of Caulis Akebiaes, 5 parts of Herba Euphorbiae Helioscopiae, 3 parts of Medulla Tetrapanaciss, 20 parts of Fructus Lyciis, 20 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts in mountain region melon, 3 parts of Fructus Schisandrae Chinensis, 40 parts of Herba Hedyotidis Diffusaes, 10 parts of Herba Dendrobiis, 20 parts of Radix Codonopsis, 10 parts of Rhizoma Acori Graminei, 10 parts of Bulbus Lycoridis Radiataes, 5 parts of Radix Saposhnikoviaes, 20 parts of Herba Crotalariae sessilifloraes, 1 part of paclitaxel.
Above-mentioned curing cancer drug preparation method: each above-mentioned medical material is clean, airing, Periostracum Cicadae, Carapax Et Plastrum Testudinis, Agkistrodon, Scolopendra, Ramulus et folium taxi cuspidatae and paclitaxel pulverizing back is standby; 39 kinds of crude drug of all the other that will be above-mentioned mix the back with decocting in water three times, and each 30～60 minutes, concentrated extracting solution got extractum, and are dry then, pulverize, and get curing cancer drug of the present invention after Periostracum Cicadae, Carapax Et Plastrum Testudinis, Agkistrodon, Scolopendra, Ramulus et folium taxi cuspidatae and paclitaxel powder mix.
Embodiment 2:
Curing cancer drug of the present invention is got following weight portion crude drug and is carried out formulated: 15 parts of Ramulus et folium taxi cuspidataes, 15 parts of Rhizoma Phragmitiss, 5 parts of Periostracum Cicadaes, 20 parts of Radix Zanthoxylis, 15 parts of changii,radixs, 20 parts of thorn bent sticks, 15 parts of Folium Isatidis, 5 parts of Radix Polygalaes, 15 parts of Polyporus, 5 parts of Radix Campylotropis Hirtella (Herba Myrsines Africanae)s, 20 parts of Carapax Et Plastrum Testudiniss, 15 parts in Poria, 15 parts of Fructus Trichosanthis, 10 parts of Herba Achilleaes, 30 parts of Herba Portulacae Grandifloraes, 10 parts of Rhizoma Arisaematiss, 10 parts of Rhizoma Curcumae, 15 parts of Caulis Spatholobis, 15 parts of Indigo Naturaliss, 15 parts of Spica Prunellaes, 5 parts of Agkistrodons, 20 parts of Radix Et Rhizoma Rhei, 5 parts of Radix Sophorae Tonkinensiss, 15 parts of Herba Taraxacis, 15 parts of Rhizoma Paridis, 5 parts of Fructus Bruceaes, 20 parts of Wild Ganoderma, 5 parts of Scolopendras, 10 parts of Rhizoma Polygoni Cuspidati, 15 parts of Rhizoma Dioscoreae Bulbiferaes, 15 parts of Caulis Akebiaes, 5 parts of Herba Euphorbiae Helioscopiae, 10 parts of Medulla Tetrapanaciss, 30 parts of Fructus Lyciis, 30 parts of the Rhizoma Atractylodis Macrocephalaes, 30 parts in mountain region melon, 5 parts of Fructus Schisandrae Chinensis, 60 parts of Herba Hedyotidis Diffusaes, 15 parts of Herba Dendrobiis, 30 parts of Radix Codonopsis, 20 parts of Rhizoma Acori Graminei, 20 parts of Bulbus Lycoridis Radiataes, 10 parts of Radix Saposhnikoviaes, 30 parts of Herba Crotalariae sessilifloraes, 2 parts of paclitaxels.
Press the preparation method preparation of embodiment 1: each above-mentioned crude drug is clean, airing; Periostracum Cicadae, Carapax Et Plastrum Testudinis, Agkistrodon, Scolopendra, Ramulus et folium taxi cuspidatae and paclitaxel pulverizing back is standby; 39 kinds of crude drug of all the other that will be above-mentioned mix the back with decocting in water three times, and each 30～60 minutes, concentrated extracting solution got extractum, and are dry then, pulverize, and get curing cancer drug of the present invention after Periostracum Cicadae, Carapax Et Plastrum Testudinis, Agkistrodon, Scolopendra, Ramulus et folium taxi cuspidatae and paclitaxel powder mix.
Except that the powder of method for preparing, also the pharmaceutical methods of available routine is made tablet, capsule, granule, injection, oral liquid etc.
Curing cancer drug energy curing cancers of the present invention is based on the main chemical compositions and the pharmacology characteristics of above-mentioned each crude drug, and their additions produce synergistic function, so reach the effect of curing cancers.The main chemical compositions of above-mentioned each crude drug and pharmacology characteristics are described as follows:
1, Rhizoma Arisaematis
1. chemical constituent: contain cupreol-D-glucoside, 1-acetyl an aromatic plant metioned in ancient books-β-click, cupreol, B-carboline and aminoacid, triterpene saponin.
2. pharmacology: significant convulsion and sedation are arranged,, tangible analgesic effect (hot plate method) is arranged, can significantly increase the secretion of respiratory tract mucus, play phlegm-dispelling functions, to murine sarcoma S180, HCA (hepatocarcinoma) solid type, hysteroma U through mouse peritoneal injection decoct
14(transplanting in the mice person for squamous epithelial cancer type cervical cancer) has the obvious suppression effect.
2, Fructus Trichosanthis
1. chemical constituent: fruit contains triterpene saponin, aminoacid, saccharide, organic acid; Seed contains oleic acid, linoleic acid and phytosterin compound.
2. pharmacology: have the expansion heart coronary artery; the effect of coronary blood flow increasing; acute myocardial ischemia there is significant protective effect; exsomatize choriocarcinoma cell proliferation and HIV (human immunodeficiency virus) had had strong inhibitory effects; diabetes there is certain therapeutical effect; the energy enhancing body's immunological function has antiulcer, the antibiotic and anti-ageing effect of waiting for a long time.
3, Herba Achilleae
1. chemical constituent: contain Millefolium element, Camphora, Chamazulene, remove the female element of acetyl, Fumaric acid, equisetic acid etc.
2. pharmacology: the water of herb or alcohol extract can significantly suppress the growth of murine sarcoma S180, rat w256, and can prolong the life of ehrlich carcinoma (EAC) mice, water decoction-alcohol sedimentation liquid has inhibitory action to the allergy of active sensitization, can obviously prolong the mouse sleep time that pentobarbital sodium causes.
4, Ramulus et folium taxi cuspidatae
1. chemical constituent: contain Ramulus et folium taxi cuspidatae outer coffin, taxol, baccatin III, more than 40 kind of active drugs such as alkaloid, yew amylose, Ramulus et folium taxi cuspidatae flavone very much.
2. function with cure mainly: inducing diuresis to remove edema, treatment nephropathy, diabetes, nephritis edema, dysuria, gonorrhea etc.The kidney warming stimulates the menstrual flow, treats effects such as menoxenia, postnatal blood stasis, dysmenorrhea.
5, Rhizoma Phragmitis
1. chemical constituent: contain Coixol, tricin, asparagus cochinchinensis amide, polysaccharide, alditol and water-soluble saccharides etc.
2. pharmacology: can reduce the mice autonomic movement, the heating that pyrogenicsubstance is caused has refrigeration function, stronger antitussive effect is arranged, its contained poly powder has significant antitumaous effect, can strengthen normal cell and resist the erosion of cancerous cell, the enhancing body resistance against diseases, and side effect is little, and heavy dose of Semen Coicis have hypoglycemic activity.
6, Poria
1. chemical constituent: contain pachyman, pachymic acid, piece pachymic acid, eburicoic acid, loose Siberian cocklebur acid, ergosterol etc.
2. pharmacology: diuresis is arranged, and is the effect of other compositions beyond the potassium salt, with to influence renal tubules relevant to the heavily absorption of sodium ion, can make rosette formation rate and phytohaemagglutinin bring out lymhocyte transformation rate and significantly rise.Also have antitumor in addition, protect the liver, promote effects such as hemopoietic function, calmness, blood sugar lowering.
7, Polyporus
1. chemical constituent: contain Polyporus polysaccharide, ergosterol, biotin, a-hydroxyl-tetracosa carbon acid of similar pachyman etc.
2. pharmacology: can be by suppressing renal tubules to water, electrolytical heavy absorption, reach diuresis, polyporusum bellatus can suppress the synthetic activity that reaches cyclic adenosine monophosphate of DNA in the mice S180 ascites cells, protect the liver, resist radiation, antibiotic, defying age in addition in addition, promote effects such as immunity, enhancing platelet aggregation.
8, Periostracum Cicadae
1. chemical constituent: contain chitin, pteridine class pigment, different xanthin pterin, red pterin, adenosine triphosphatase, several amino acids etc.
2. pharmacology: can reduce the mice convulsion death toll that rather causes of soil, prolong life cycle, improve vitality, can significantly slow down the heart rate of rabbit, erythrocyte is had certain protective role.Also has calmness, convulsion, immunosuppressant, analgesic, reduction capillary tube property all in addition, effects such as antitumor, analgesia.
9, Carapax Et Plastrum Testudinis
1. chemical constituent: contain protein, ossein, aminoacid, calcium carbonate etc.
2. pharmacology: thyroid, adrenal gland's function that can effectively reduce hyperthyroid deficiency of YIN rat, can make the thymus of hyperthyroid deficiency of YIN rat atrophic recover growth, improve cellular immunization and immunologic function, improve lymhocyte transformation rate, serum 1gC content is increased.Effect such as also have mutation, excited uterus, calmness in addition, enrich blood.
10, Radix Polygalae
1. chemical constituent: contain polygalic acid A～G, polygalite, 3-hydroxyl-2,6,7,8-Si Jia Yang Ji Zhan ton ketone 2,3,6,7,8-Wu Jia Yang Ji Zhan ton ketone 3,4,5-trimethoxy cinnamic acid, Radix Polygalae, alkali, 1-oxygen carbonyl-B-carboline, 1-carbethoxyl group-B-carboline etc.
2. pharmacology: the stronger effect of dispelling is arranged, cyclic adenosine monophosphate phosphorus diesterase is had inhibitory action, can strengthen muscle power and the intelligence of animal, stronger hemolytic is arranged.
11, Rhizoma Paridis
1. chemical constituent: contain multiple steroid grass, Rhizoma Paridis ZAOCAO I, II are wherein arranged, partially such saponin, dioscin, the very thin dioscin of sapogenin.
2. pharmacology: decoct is to staphylococcus aureus, dysentery bar disease, Bacillus typhi and bacillus pyocyaneus etc. have bacteriostasis in various degree, has antitumor, the spermicide effect, the asthma that the histamine nebulization is brought out has tangible antiasthmatic effect, the cough that sulfur dioxide is brought out has obvious effect, but does not have phlegm-dispelling functions.
12, Wild Ganoderma
1. chemical constituent: contain ergosterol, fungal lysozyme, γ-, trimethylamine butanoic acid, aminoacid, polypeptide, polysaccharide A～C etc.
2. pharmacology: the water-soluble part of extract has antitumor action, and lucidum liquid can make intraperitoneal mouse macrophage phagocytic percentage rate and phagocytic index increase, and ganoderan can significantly promote the inductive normal mouse antibody forming cell reaction of sheep red blood cell (SRBC).
13, Rhizoma Polygoni Cuspidati
1. chemical constituent: contain emodin, chrysophanol, physcione-8-heteroside stilbene diphenol, resvertrol glycosides, resveratrol, polygonin etc., and contain condensed tannin and several polysaccharides.
2. pharmacology: decocting liquid has inhibitory action to coccus, card ground coccus, first type or beta hemolytic streptococcus, the escherichia coli of golden yellow Fructus Vitis viniferae, high concentration also has fire action extremely to hook end spiral, its decocting liquid has tangible antivirus action, the formic acid that the intravenous rabbit injection is extracted from Rhizoma Polygoni Cuspidati can cause hypoglycemia shock.
14, Caulis Akebiae
1. chemical constituent: stem contains stigmasterol etc.Root contains saponin, and hydrolysis gets oleanolic acid and glucose, rhamnose.
2. pharmacology: the rabbit tincture gavages, the diuresis of the oral or equal highly significant of intravenous injection, and preliminary in vitro tests result shows, water logging agent or decoct have in various degree inhibitory action to multiple pathomycete.
15, Medulla Tetrapanacis
1. chemical constituent: contain inositol, poly pentose, poly methylpentose, arabinose, lactose, galacturonic acid etc.
2. alcohol extract 4g/Kg irritates stomach has tangible diuresis to rat, and water extract also can make the urine amount slightly increase, and can be used for the treatment of urinary system infection clinically, and urine leaching is puckery obstructed, and hematuria has the effect that promotes galactopoiesis, can treat agalactia.Also has antiinflammatory action in addition.
16, Fructus Lycii
1. chemical constituent: contain multivitamins such as betanin, Calyx seu fructus physalis red pigment, lycium barbarum polysaccharide and carotene.
2. pharmacology: lipotropic effect is arranged, the effect of the choline-like of plan is arranged, the water extract intravenous injection of Fructus Lycii can cause that the Sanguis Leporis seu oryctolagi pressure drop is low, breathe excited, can strengthen the immunization of cell and body fluid, hemopoietic function there is facilitation, has defying age, mutation, antitumor, protect the liver and hypoglycemic activity.
17, Radix Codonopsis
1. chemical constituent: contain triterpenes thing freidelin, the I of tangshenoside, codopiloic acid, codonolactone, atractyloide II, III, alnulin acetas, syringoside, polysaccharide etc.
2. pharmacology: can improve the animal learning memory ability; spontaneous activity in mice there is inhibitory action; acute ischemia due to the counterweight body has the certain protection effect; erythrocyte and hemoglobin are increased; can remove the animal microcirculation disturbance; antiulcer action is arranged, can damage by anti-gastric mucosa, enhance immunity and oxygen lack resistant function are arranged.
18, Rhizoma Acori Graminei
1. chemical constituent: rhizome contains volatile oil, in the oil main constituent be α-, β-, γ-asaricin, and thin aldehyde, bisasaricin, eugenol and safrole etc. are arranged.
2. pharmacology: volatile oil has sedation, anesthesia duration that can also the significant prolongation pentobarbital sodium, for oral administration can facilitating digestion liquid secretion and prevent gastrointestinal abnormal fermentation, and the effect of loose intestinal tube smooth muscle contraction is arranged.Also have cooling, sterilization, diuresis and effect such as anticancer.
19, Bulbus Lycoridis Radiatae
1. chemical constituent: contain lycorine, galantamine, lycoramine alkali etc.
2. pharmacology: can excited intestinal tube, suppress cardiovascular system, dwindle pupil, some central paralysis diseases also there is an irregular therapeutic effect, calmness, analgesia refrigeration function are arranged, anesthetized dog, rabbit, cat intravenous injection lycorine have slight hypotensive effect, blood sugar lowering, excited uterus do not arranged in addition, stimulate adrenal cortex function, anticancer, suppress drug metabolism, kill the ameba effect.
20, Herba Dendrobii
1. chemical constituent: stem contains p-Coumaric Acid alkyl esters, polysaccharide.
2. pharmacology: to aldose in the cataractous lens due to the galactose also 6 enzymes, the polyhydric alcohol active ANOMALOUS VARIATIONS of taking off the convulsion enzyme have and suppress or role of correcting, dendrobium polysaccharide has the T cell of enhancing and the active effect of macrophage immunity, can significantly improve superoxide dismutase (SOD) level, thereby play the effect that reduces lipid peroxide (LPO).
21, Herba Hedyotidis Diffusae
1. chemical constituent: contain volatile oil, Main Ingredients and Appearance is a methylnonanone in the oil, and myristicin still contains Quercetin, Quercitroside, isoquercitrin, avicularin hyperin, rutin etc.
2. pharmacology: contained avicularin has diuresis, and action intensity is not as good as 1/4 of theophylline, and therapeutic index is bigger, and anesthetized dog is had hypotensive effect, but the persistent period is short, easily produces tachyphylaxis, with the Radix Cirsii Japonici logotype, an irregular antihepatocarcinoma effect is arranged.
22, Fructus Schisandrae Chinensis
1. chemical constituent: contain multiple lignan component, wherein Fructus Schisandrae Chinensis, schizandrin, schisandrin and pure second, schisantherin A and ester the second grade.
2. pharmacology: the central nervous system is had excitation, can improve people's intellectual activity, increase work efficiency, tangible breathing excitement and phlegm-dispelling functions are arranged, anti-nephropathy change effect is arranged, the enzyme of falling and hepatoprotective effect are arranged, and the non-specific immunity of energy enhancing body has effects such as the autonomic movement of inhibition, reduction body temperature, analgesia, pre-ulcer to laboratory animal.
23, Radix Saposhnikoviae
1. chemical constituent: contain 5-0-methyl visamminol glycosides, 3-0-Radix Angelicae Sinensis acyl hamaudol, cimifugin, peucedanin etc.
2. pharmacology: staphylococcus aureus, beta hemolytic streptococcus, streptococcus pneumoniae and fungus are had bacteriostasis, anti-allergic effects is arranged, can suppress Cavia porcellus and shrink, strengthen the phagocytic function of Turnover of Mouse Peritoneal Macrophages from full trachea, ileum smooth muscle anaphylaxis.Analgesic in addition in addition, analgesia, calmness and antiinflammatory action.
24, Herba Crotalariae sessiliflorae
1. chemical constituent: contain multiple alkaloids such as colchicine, starch-containing in addition, protein, fat and multiple sugar.
2. pharmacology: the propagation that contained colchicine can anticancer, breast carcinoma particularly, has phlegm-dispelling functions, anoxia enduring and antifatigue effect can be arranged the asthma that antihistamine causes, in addition can also the enhancing body cellular immunity, prolong barbital sodium length of one's sleep, and the delayed hypersensitivity due to the dinitrochlorobenzene CNCB is had inhibitory action.
25, mountain region melon
1. chemical constituent: contain physcione, chrysophanol, lupeol, gallanol, melampyrin, Fumaric acid etc.
2. pharmacology: infusion has inhibitory action to dermatophytess such as Trichophyton concentricunm, Du's big belly microspore tinea bacterium difficult to understand, red dermatophytes in vitro, can significantly strengthen RADIX ACONITI LATERALIS PREPARATA and the analgesic activity of processing Radix Aconiti, it is that JTC26 has inhibitory action that human cervical carcinoma cell is cultivated.
26, the Rhizoma Atractylodis Macrocephalae
1. chemical constituent: rhizome contains volatile oil, and main component is an atractylone in the oil, atractylodes lactone A, contains 3-B-acetoxyl group atractylone, 3-B-hydroxyl an aromatic plant metioned in ancient books atractylone etc. in addition.
2. pharmacology: various animals are all had tangible diuresis; the effect of blood sugar lowering is arranged; mice decoct for oral administration has the liver protecting; prevent the effect of the hepatic glycogen minimizing that carbon tetrachloride causes; oral its decoct has blood coagulation resisting function, gavages to promote mice weight increase and muscular strength to strengthen, to acrothesium floccosum; star-shaped nocardia, meningococcus has inhibitory action.
27, Herba Euphorbiae Helioscopiae
1. chemical constituent: contain the Herba Euphorbiae Helioscopiae saponin, Quercetin-3,5-digalactosyl glycosides, B-dihydrofucosterol, Helioscopiol, butanoic acid and calcium malate.
2. pharmacology: the stem and leaf decoct is irritated stomach, and the artificial fever rabbit is had slight cooling effect, and its antipyretic effect also has certain influence like irrelevant with hypophysis-adrenal system to trachea, blood vessel and smooth muscle, also has effects such as antibacterial parasite killing eliminates the phlegm in addition.
28, Rhizoma Dioscoreae Bulbiferae
1. chemical constituent: contain diobulbine A, saponin, tannin and starch.
2. pharmacology: the thyromegaly due to the iodine deficiency food is had certain therapeutical effect, and this effect may be wherein to contain due to the iodine, to exsomatizing or at the body frog heart inhibitory action being arranged all, the isolated rabbit intestinal also there is inhibitory action, the excited uterus of energy, acetone extract is injected in rat abdominal cavity, can suppress feed.
3. function with cure mainly: heat-clearing and toxic substances removing, the removing heat from blood wart that disappears.Be used for laryngopharynx swelling and pain, the disease sore that swells, snake bite and insect sting, goiter, the spitting of blood of spitting blood.
29, Scolopendra
1. chemical constituent: the fatty acid such as albumen egg, oxylysine, hexadecenoic acid that contains histamine, dissolved blood protein, formic acid, tool sulfide linkage.
2. pharmacology: can cause that the excited earlier back of tame rabbit intestinal suppresses, can reduce the loose of infertile uterus, weaken the normal contraction in uterus, its effect can be by effects such as epinephrine fungus, antiinflammatory, analgesia, defying age, enhancing myocardial contractions.
30, Fructus Bruceae
1. chemical constituent: contain yatanoside A～C, bruceine A～I, Brusatol.
2. pharmacology: protozoon such as ameba, paramecium and even plasmodium are all had killing effect, anti-disease effect is arranged, whipworm, ascarid, cestode and trichomonal vaginitis etc. are killed effect, and java brucea seed or oil can produce normal skin or mucosa face to stimulate, and controls wart clinically or papilloma is effective.Also have excited uterus in addition, promote enterokinesia, kill effects such as larva.
31, Herba Taraxaci
1. chemical constituent: contain yatanoside A～C, bruceine A～I, Brusatol.
2. pharmacology: staphylococcus aureus Resistant strain, Hemolytic streptococcus are had very strong killing action, and alcohol extract can suppress tubercule bacillus, can also kill leptospira, helicobacter pylori and some fungus.Also have in addition that antitumor protects the liver, function of gallbladder promoting, diuresis, excitement or inhibition heart, gastric acid inhibitory secretory action.
32, Radix Sophorae Tonkinensis
1. chemical constituent: contain matrine, oxymatrine, N-Methylcytisine, Anagyrine, sophoradin, sophoranochromene, sophoradin, pterocarpin, maackiain etc.
2. pharmacology: tumor, ascitic type liver cancer solid type ascites hepatocarcinoma, Meth A tumor cell, leukaemia in tumor, the solid type Jitian in the ascitic type Jitian are had inhibitory action.Also have cooling, antiulcer, the effect of leukocyte increasing quantity in addition.
33, Radix Et Rhizoma Rhei
1. chemical constituent: contain anthraquinone glycoside and dissociated anthraquinone derivant, the latter comprises chrysophanic acid, emodin, chrysophanol, aloe-emodin, physcione etc.
2. pharmacology: discharge function is arranged, can cause constipation after rushing down down, to the cymbidium positive bacteria, gram-negative bacteria all has antibacterial action, to golden yellow staphylococcus, streptococcus, diphtheria corynebacterium, bacillus subtilis, anthrax bacillus, Bacillus typhi, Salmonella paratyphi and dysentery have inhibitory action, and mouse black-in lymphoma, breast carcinoma and ehrlich carcinoma are had inhibitory action.
34, Agkistrodon
1. chemical constituent: contain dry Serpentis body master and contain protein, fat and aminoacid etc., contain in the snakehead portion poison gland of living and contain spermine, ophidine etc. in blood poison, the muscle.
2. pharmacology: direct blood vessel dilating, play the effect of blood pressure lowering, can make the fibrinogen deposition in the blood plasma is fibrin, because fibrinogenic exhaustion and hyperamization liquid lose and coagulates, causes hemorrhage difficulty to be ended, also have in addition calm, protect effects such as dormancy, analgesia.
35, Rhizoma Curcumae
1. chemical constituent: rhizome contains volatile oil, and the composition that contains in the oil has the Rhizoma Curcumae furanone, table Rhizoma Curcumae furanone, Rhizoma Curcumae furan.Curdione, curcumenol, Camphora, Borneolum Syntheticum.
2. pharmacology: antitumaous effect is arranged, give mouse stomach with Oleum Curcumae, Dichlorodiphenyl Acetate peritonitis has inhibitory action, lumbar injection is to the local swollen obvious treatment effect that has of mice, mice ear inflammation and subcutaneous agar granuloma and the cotton granuloma hypertrophy of rat there is inhibitory action, can blood flow increasing, the growths of staphylococcus glucose bacterium, enterobacteria etc. there is inhibitory action.
36, Caulis Spatholobi
1. chemical constituent: contain formoononetin, ononin, prunusetin., glycosides grass and look into ear ester table and look into essence, protocatechuic acid etc.
2. pharmacology: decoct has blood tonification effect to the rabbit of experimental anemia, and its hemocyte is increased, and hemoglobin raises, and decoct exsomatizes to Bufo siccus and is inhibitory action in the heart emblem, can cause blood pressure drops, can strengthen the uterus rhythmicity and shrink.
37, Indigo Naturalis
1. chemical constituent: mainly contain indigoly, other contains indirubin.
2. pharmacology: dermatophytess such as microsporum canis, microsporon gypseum and red mentagrophytes are had inhibitory action, and pure preserved material body is to anthrax bacillus, and streptococcus pneumoniae and Staphylococcus albus all have inhibitory action.Anticancer in addition in addition, protect the liver, effect such as coagulant.
38, Spica Prunellae
1. chemical constituent: contain prunellin, ursolic acid, oleanolic acid, hyperin.
2. pharmacology: the aldehyde ketone reductase is had inhibitory action.Also have effects such as mutation, anticancer, calm, convulsion, edema and diuresis in addition.
39, Radix Zanthoxyli
1. chemical constituent: contain nitidine, oxyterihanine, hottentot tea glycosides etc.
2. pharmacology: analgesic activity is arranged, with pentobarbital sodium synergism is arranged, courageous and upright streptococcus and staphylococcus aureus are had stronger inhibitory action, and myenteron due to acetylcholine and the barium chloride is shunk the obvious suppression effect, and multiple cancerous cell is had the obvious suppression effect.
40, Folium Isatidis
1. chemical constituent: contain sinigrin, indirubin, Yin tremnble glycosides, cupreol, adenosine, palm fibre, palmitic acid acid and sucrose etc.
2. pharmacology: anti-endotoxin effect is arranged; can protect mouse macrophage and suppress inflammatory factor secretion or direct antiinflammatory; remarkable promotion immune function of mice is arranged; the Radix Isatidis polysaccharide can obviously strengthen antibody forming cell's function; improve the wide rate of bursting of mice carbon granules; antitumor action is arranged, and indirubin has the effect that destroys the leukaemia.
41, Herba Portulacae Grandiflorae
1. chemical constituent: contain scutellarin, scutellarein, carthamin, isocarthamidin and alkaloid.
2. pharmacology: with methylene blue test tube method screening test, the acute myeloblastic leukemia leukocyte there is very light inhibitory action, preserved material is through ethanol extraction, the crystallization of extract has diuresis to animal, and decoct has inhibitory action external to staphylococcus aureus, Fu Shi dysentery bacillus, Bacillus typhi, escherichia coli, bacillus pyocyaneus.
42, Radix Campylotropis Hirtella (Herba Myrsines Africanae)
1. chemical constituent: contain volatile oil, main constituent is a limonene in the oil, myrcene, β-ocimene.Other contains kokusagine, bacterium taro alkali, herniarin etc.
2. pharmacology: the effect of anti-experimental character gastric ulcer is arranged, and level and smooth burst of motion has two-way function to intestinal, gavages pepper water extract 10g/Kg, 20g/Kg or ether extract 3.0ml/Kg, the thrombosis that can both prevent electricity irritation carotid artery to cause respectively to rat.In addition, also have diarrhea, protect the liver, analgesia, dirty inflammation, local anesthesia is antibacterial and the effect of acaricide demodicid mite.
43, thorn bent stick
1. chemical constituent: contain the thorn king and add glycosides A, thorn king and add that glycosides B, thorn king add glycosides B1, the thorn king adds glycosides C～G, polysaccharide etc.
2. pharmacology: the central nervous system is had excitement, inhibition and anticonvulsant action; extract and glycoside have anti-liquid work to use; to transplanting cancer; the medicine spy brings out cancer, and the spontaneous leukemia of the transfer of cancer and mice all has certain inhibitory action, can alleviate the toxicity of cancer therapy drug; the non-specific immunity of energy enhancing body; can regulate pathological process, make it be tending towards normalization, the tool anti-aging effects.
44, mountain root flower
1. chemical constituent: fatty oil, fatty acid, aminoacid, volatile oil, polysaccharide etc.
2. pharmacology: the Radix Changii polysaccharide can promote the mice natural killer cell activity, activating macrophage Cb receptor, significantly improve normal mouse peritoneal macrophage Yc-garland formation rate, enhancing body anti-cancer, anti-infection ability, generation to lipid peroxide in the external rat liver homogenate supernatant has the obvious suppression effect, and is the strongest with the effect of methanolic extract.
45, paclitaxel
1. chemical constituent: mainly be made up of taxane-ring and side chain, molecular formula is that C47H51N014 is the natural secondary metabolites of terpenoid circulus.
2. anticancer mechanism: paclitaxel can combine with trace protein, and promotes its polymerization, and the mitosis of anticancer effectively stops the propagation of interfere with cancer cells, and has strong activity and unique anticancer mechanism.、
3. function cures mainly: cancer therapy drug is one of best medicine of treatment transitivity ovarian cancer and breast carcinoma, simultaneously pulmonary carcinoma, esophageal carcinoma is also had significant curative effect, and nephritis and parvovirus inflammation are had obvious inhibition.
Medical cancer in facts have proved is carried out proportioning by the necessary medicine of human body cancer in conjunction with modern science, through body biochemical it can produce several times or tens times control the cancer effect, thereby produce huge antitumaous effect.Mainly has unique anticancer mechanism, can combine with trace albumin, and promote its polymerization, the mitosis of anticancer, the propagation that effectively stops cancerous cell, can be normal cell for the carninomatosis patient tames transformation repairing cancerous cell, and can produce the huge cancer antitumaous effect of controlling, rapid human body immunity improving function, cure each adenocarcinoid, rectal cancer, breast carcinoma, lymphatic cancer, carcinoma of prostate, uterus carcinoma, ovarian cancer, cancer of biliary duct, esophageal carcinoma, the esophageal carcinoma, gastric cancer, all kinds of small cell carcinomas, pulmonary carcinoma, skin carcinoma, bladder cancer, leukemia, hepatocarcinoma, chorionic epithelioma, all kinds of cancers such as leukemia and cancer pain, and to the high leukemia of leukocyte and to be transferred to all kinds of middle and terminal cancer effects of skeleton obvious, through tens of skies the cancerous protuberance piece is disappeared, cure above-mentioned all kinds of cancers in 1 year, make the cancer patient at no pain, fast, efficiently, rehabilitation is cured under the situation of safety.
Below by test the example beneficial effect of the present invention is further specified.
The test example
Curing cancer drug of the present invention general 1～2 course of treatment (30 days courses of treatment) can take effect, the cancer operation patient, and postoperative began to take in 10 to 15 days, best results, the lighter can cure for one course of treatment, and mid-term, carninomatosis patient general treatment was 2～4 year course of treatment, and the advanced carcinoma patient treats 6～12 courses of treatment.Clinical practice for many years shows that recurrence appears in none example, shifts; Put, the chemotherapy patients receives treatment and can take simultaneously, has the efficacy enhancing and toxicity reducing effect.General patient, after 3 to 6 courses of treatment, every test rating is all normal, can change the clothes low dose and keep under physician guidance, to prevent diffusion and to shift; Severe patient increases under physician guidance according to the state of an illness and to take the course of treatment.
Now will be exemplified below with patient's case, the result of curing cancer drug of the present invention (once using the medicine name of " edema due to wind pathogen Shen Dan " during the treatment carninomatosis):
Lin Zhixing, the man, 46 years old, live Chaoyang Lu, Zhangpu County Sui An town, Fujian No. 108, suffer from hepatocarcinoma through hospital diagnosis, take cancer therapy drug of the present invention after 3 courses of treatment, do not recur so far in healing in 2003.
Chen Minghui, the man, 49 years old, live in the eastern Rong Lu in Zhangpu County Sui An town, Fujian No. 26, get a cancer of the stomach through hospital diagnosis, take cancer therapy drug of the present invention after 3 courses of treatment, check is cured.
The thin younger sister of Liu, the woman, 38 years old, fragrance people from city, ZhangZhou suffered from breast cancer through hospital diagnosis, shifts behind the excision, took cancer therapy drug of the present invention after 2 courses of treatment, do not recur so far after curing in 2002.
Xu Ruihua, the woman, 46 years old, Zhangpu County Sui An town North Street people from neighbourhood committee through the hospital diagnosis ovarian cancer, shifted behind the excision, take 2 year year of cancer therapy drug of the present invention journey after, check is cured.
Zhou Wenhai, the man, 35, in year, Zhangpu County Sui An town Sui Xi people from neighbourhood committee through hospital's hospital diagnosis cases with leukemia, takes cancer therapy drug of the present invention after 4 courses of treatment, the check healing.
Wang Wenzhang, the man, 42 years old, the Hok-lo suffered from carcinoma of prostate through hospital diagnosis, took cancer therapy drug of the present invention after 2 courses of treatment, cured rehabilitation in 1989 18 years so far.
Chen Kaisheng, the man, 55 years old, people from Foochow, Fujian Province suffered from cancer of biliary duct through hospital diagnosis, took cancer therapy drug of the present invention after 3 courses of treatment, cured rehabilitation so far in 1996.
Lin Yuying, the woman, 45 years old, the Cantonese suffered from uterus carcinoma through hospital diagnosis, took cancer therapy drug of the present invention after 3 courses of treatment, cured rehabilitation so far in 1997.
He Juan, the woman, 26 years old, people from Chongqing, Sichuan suffered from colon cancer through hospital diagnosis, took cancer therapy drug of the present invention after 2 courses of treatment, cured rehabilitation so far in check in 2003.
With curing cancer drug of the present invention the different cancer patient of hundreds of example weight has been carried out treatment in various degree, most of behind clothes, all take a favorable turn and cure, its effective percentage reaches 99%, and cure rate reaches more than 85%.
The main feature of curing cancer drug of the present invention is: distinguished bad cell through biochemical energy after (one) clothes are gone into human body; its inhibition domestication is transformed and is repaired cancerous cell, does not damage human normal cell and the cancerous tumor cell that protects in cell, the normal and undesired cell of transformation.(2) hydrogen atom in the cancerous cell is captured in the secretion of restriction and minimizing transaminase, reduces cancerous cell and loses the growth and breeding ability.(3) foreign substance and the canceration molecule that cause cell carcinogenesis in the body are excreted by defecation, just the reason of the traditional Chinese medical science described " ten thousand sick poison rise, and go a poison, ten thousand to recover ".(4) repair combination human inner cell molecule again, the diseased cells normality is recovered, and the normal cell function is arranged, continue as the human life service.(5) cancer therapy drug of the present invention contains hundreds of human life desired nutritional material, is again simultaneously the effector substance that suppresses, tames, transforms, repairs cancerous cell.Above superiority is that traditional Chinese and western medicine adopts " killing method " fundamentally just not possess.Medicine of the present invention can make cancerous cell become normal cell and continue as the health service, and this is the greatest feature of " suppress, tame, transform, repair ".Cancer therapy drug of the present invention is the protector of the cell of human life; be again that the transformation inverse cancer cell is Normocellular effect medicine; it is the energy matter of human body biochemistry; its maximum characteristics are: only suppress, tame, transform, repair cancerous cell; remove the interior carcinogen of body to save cancer patient's passive life, strive for that the patient forever has good health and a long life.The needed by human material should be sound, disappears, grow necessary nutrient substance by the ancient medicine definition, and these materials are QI and blood by modern science, aminoacid, the plain class of enzyme, polysaccharide, vitamin, constant and dimension secondary element etc.Some in the middle of them is human life's a nutrient substance, is again that " suppress, tame, transform, repair " cancerous cell is Normocellular essential material.The monarch and his subjects make assistant by the traditional Chinese medical science, must still have comparative advantage by material, treat cancer by its scientific formula, can be normal cell for cancer patient inhibition, domestication, transformation, repairing cancerous cell, and this also is the value meaning of Chinese medicine institute of motherland tool characteristic and exploitation Chinese medicine.
Claims (3)
1. curing cancer drug, it is characterized in that, each crude drug below described curing cancer drug is selected carries out formulated in combination in the following weight parts scope and forms: 10～20 parts of Ramulus et folium taxi cuspidataes, 10～30 parts of Rhizoma Phragmitiss, 3～8 parts of Periostracum Cicadaes, 10～20 parts of Radix Zanthoxylis, 5～15 parts of changii,radixs, 20～30 parts of thorn bent sticks, 5～15 parts of Folium Isatidis, 3～5 parts of Radix Polygalaes, 5～15 parts of Polyporus, 3～8 parts of Radix Campylotropis Hirtella (Herba Myrsines Africanae)s, 10～20 parts of Carapax Et Plastrum Testudiniss, 10～15 parts in Poria, 5～15 parts of Fructus Trichosanthis, 5～10 parts of Herba Achilleaes, 20～30 parts of Herba Portulacae Grandifloraes, 5～10 parts of Rhizoma Arisaematiss, 5～10 parts of Rhizoma Curcumae, 5～15 parts of Caulis Spatholobis, 3～8 parts of Indigo Naturaliss, 5～15 parts of Spica Prunellaes, 3～8 parts of Agkistrodons, 10～20 parts of Radix Et Rhizoma Rhei, 3～8 parts of Radix Sophorae Tonkinensiss, 5～15 parts of Herba Taraxacis, 10～30 parts of Rhizoma Paridis, 3～8 parts of Fructus Bruceaes, 20～40 parts of Wild Ganoderma, 3～8 parts of Scolopendras, 3～8 parts of Rhizoma Polygoni Cuspidati, 5～15 parts of Rhizoma Dioscoreae Bulbiferaes, 10～20 parts of Caulis Akebiaes, 3～8 parts of Herba Euphorbiae Helioscopiae, 5～10 parts of Medulla Tetrapanaciss, 10～30 parts of Fructus Lyciis, 10～30 parts of the Rhizoma Atractylodis Macrocephalaes, 20～40 parts in mountain region melon, 3～8 parts of Fructus Schisandrae Chinensis, 40～60 parts of Herba Hedyotidis Diffusaes, 5～15 parts of Herba Dendrobiis, 20～40 parts of Radix Codonopsis, 10～25 parts of Rhizoma Acori Graminei, 10～25 parts of Bulbus Lycoridis Radiataes, 5～15 parts of Radix Saposhnikoviaes, 20～40 parts of Herba Crotalariae sessilifloraes, 1～3 part of paclitaxel.
2. by the preparation method of the described curing cancer drug of claim 1, it is characterized in that, each above-mentioned crude drug is clean, airing, Periostracum Cicadae, Carapax Et Plastrum Testudinis, Agkistrodon, Scolopendra, Ramulus et folium taxi cuspidatae and paclitaxel pulverizing back is standby; 39 kinds of crude drug of all the other that will be above-mentioned mix the back with decocting in water three times, and each 30～60 minutes, concentrated extracting solution got extractum, and are dry then, pulverize, and get this curing cancer drug after Periostracum Cicadae, Carapax Et Plastrum Testudinis, Agkistrodon, Scolopendra, Ramulus et folium taxi cuspidatae and paclitaxel powder mix.
3. by the described curing cancer drug of claim 1, it is characterized in that described curing cancer drug is tablet, capsule, granule, injection, oral liquid.
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